LiteFold/GO · Datasets at Hugging Face

GO:0005854

5,854

nascent polypeptide-associated complex

cellular_component

A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.

[ "PMID:12475173", "PMID:7568149" ]

null

[ "NAC", "NACA" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:0032991" ]

[ "part_of GO:0005737" ]

[ "part_of" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:0032991" ]

[]

null

false

true

6

GO:0005859

5,859

muscle myosin complex

cellular_component

A filament of myosin found in a muscle cell of any type.

[ "GOC:mah" ]

null

[]

[ "GO:0016460" ]

[ "part_of GO:0043292" ]

[ "part_of" ]

[ "GO:0043292" ]

[ "GO:0016460", "GO:0043292" ]

[ "GO:0016460", "part_of GO:0043292" ]

[]

null

false

true

8

GO:0005861

5,861

troponin complex

cellular_component

A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction.

[ "ISBN:0815316194" ]

null

[]

[ "GO:0032991" ]

[ "part_of GO:0005865" ]

[ "part_of" ]

[ "GO:0005865" ]

[ "GO:0005865", "GO:0032991" ]

[]

null

false

true

7

GO:0005863

5,863

striated muscle myosin thick filament

cellular_component

Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils.

[ "GOC:mtg_muscle", "ISBN:0815316194" ]

null

[]

[ "GO:0032982", "GO:0036379" ]

[ "has_part GO:0005859", "part_of GO:0030017" ]

[ "has_part", "part_of" ]

[ "GO:0005859", "GO:0030017" ]

[ "GO:0005859", "GO:0030017", "GO:0032982", "GO:0036379" ]

[]

null

false

true

2

GO:0005865

5,865

striated muscle thin filament

cellular_component

Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.

[ "ISBN:0815316194" ]

null

[]

[ "GO:0036379" ]

[ "part_of GO:0015629", "part_of GO:0030017" ]

[ "part_of", "part_of" ]

[ "GO:0015629", "GO:0030017" ]

[ "GO:0015629", "GO:0030017", "GO:0036379" ]

[]

null

false

true

8

GO:0005868

5,868

cytoplasmic dynein complex

cellular_component

Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of cent...

[ "GOC:cilia", "GOC:hla", "GOC:krc", "GOC:mah", "PMID:12600311" ]

Note that this term is labelled based on phylogenetic classification and community usage, rather than strict cellular localization. Cytoplasmic dynein complexes may contain ciliary dyneins; therefore the term is not linked to 'cytoplasm'. Cytoplasmic dynein complexes do not contain axonemal dyneins; see GO:0005858 axon...

[ "cytoplasmic dynein heavy chain", "cytoplasmic dynein intermediate chain", "cytoplasmic dynein intermediate light chain", "cytoplasmic dynein light chain" ]

[ "NARROW", "NARROW", "NARROW", "NARROW" ]

[]

[ "GO:0030286" ]

[]

[ "GO:0030286" ]

[]

null

false

true

6

GO:0005869

5,869

dynactin complex

cellular_component

A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach.

[ "ISBN:0198506732" ]

null

[]

[ "GO:0005875" ]

[ "part_of GO:0015629" ]

[ "part_of" ]

[ "GO:0015629" ]

[ "GO:0005875", "GO:0015629" ]

[]

null

false

true

7

GO:0005870

5,870

actin capping protein of dynactin complex

cellular_component

A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex.

[ "GOC:jl", "PMID:18221362", "PMID:18544499" ]

null

[]

[ "GO:0008290" ]

[ "part_of GO:0005869" ]

[ "part_of" ]

[ "GO:0005869" ]

[ "GO:0005869", "GO:0008290" ]

[ "GO:0008290", "part_of GO:0005869" ]

[]

null

false

true

4

GO:0005871

5,871

kinesin complex

cellular_component

Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain addi...

[ "GOC:mah", "PMID:32842864" ]

null

[]

[ "GO:0005875" ]

[]

[ "GO:0005875" ]

[]

null

false

true

5

GO:0005872

5,872

minus-end kinesin complex

cellular_component

Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule.

[ "GOC:mah" ]

null

[]

[ "GO:0005871" ]

[]

[ "GO:0005871" ]

[]

null

false

true

5

GO:0005873

5,873

plus-end kinesin complex

cellular_component

Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule.

[ "GOC:mah" ]

null

[]

[ "GO:0005871" ]

[]

[ "GO:0005871" ]

[]

null

false

true

5

GO:0005874

5,874

microtubule

cellular_component

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microt...

[ "ISBN:0879693568" ]

null

[ "microtubuli", "microtubulus", "neurotubule" ]

[ "EXACT", "EXACT", "NARROW" ]

[]

[ "goslim_metagenomics" ]

[ "NIF_Subcellular:sao1846835077", "Wikipedia:Microtubule" ]

[ "GO:0099513" ]

[ "part_of GO:0015630" ]

[ "part_of" ]

[ "GO:0015630" ]

[ "GO:0015630", "GO:0099513" ]

[]

null

false

true

6

GO:0005875

5,875

microtubule associated complex

cellular_component

Any multimeric complex connected to a microtubule.

[ "GOC:jl" ]

null

[]

[ "GO:0032991" ]

[ "part_of GO:0015630" ]

[ "part_of" ]

[ "GO:0015630" ]

[ "GO:0015630", "GO:0032991" ]

[]

null

false

true

7

GO:0005880

5,880

nuclear microtubule

cellular_component

Any microtubule in the nucleus of a cell.

[ "GOC:mah" ]

null

[]

[ "GO:0005874" ]

[ "part_of GO:0005634" ]

[ "part_of" ]

[ "GO:0005634" ]

[ "GO:0005634", "GO:0005874" ]

[ "GO:0005874", "part_of GO:0005634" ]

[]

null

false

true

8

GO:0005881

5,881

cytoplasmic microtubule

cellular_component

Any microtubule in the cytoplasm of a cell.

[ "GOC:mah" ]

null

[ "non-spindle-associated astral microtubule" ]

[ "NARROW" ]

[]

[ "GO:0005874" ]

[ "part_of GO:0005737" ]

[ "part_of" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:0005874" ]

[ "GO:0005874", "part_of GO:0005737" ]

[]

null

false

true

5

GO:0005882

5,882

intermediate filament

cellular_component

A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the c...

[ "ISBN:0198506732", "PMID:17493611", "PMID:17551517", "PMID:7979242" ]

null

[ "intermediate filament associated protein", "type I intermediate filament associated protein", "type II intermediate filament associated protein" ]

[ "RELATED", "RELATED", "RELATED" ]

[]

[ "FMA:63851", "NIF_Subcellular:sao952483289", "Wikipedia:Intermediate_filament" ]

[ "GO:0099513" ]

[ "part_of GO:0045111" ]

[ "part_of" ]

[ "GO:0045111" ]

[ "GO:0045111", "GO:0099513" ]

[]

null

false

true

7

GO:0005884

5,884

actin filament

cellular_component

A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecu...

[ "GOC:mah", "ISBN:0198506732", "PMID:10666339" ]

null

[ "microfilament" ]

[ "EXACT" ]

[]

[ "FMA:63850", "NIF_Subcellular:sao1588493326", "Wikipedia:Actin" ]

[ "GO:0099513" ]

[ "part_of GO:0015629" ]

[ "part_of" ]

[ "GO:0015629" ]

[ "GO:0015629", "GO:0099513" ]

[]

null

false

true

3

GO:0005885

5,885

Arp2/3 protein complex

cellular_component

A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.

[ "GOC:jl", "GOC:vw", "PMID:12479800" ]

null

[]

[ "GO:0032991" ]

[ "part_of GO:0015629" ]

[ "part_of" ]

[ "GO:0015629" ]

[ "GO:0015629", "GO:0032991" ]

[]

null

false

true

1

GO:0005886

5,886

plasma membrane

cellular_component

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

[ "ISBN:0716731363" ]

null

[ "bacterial inner membrane", "cell membrane", "cellular membrane", "cytoplasmic membrane", "inner endospore membrane", "integral component of plasma membrane", "integral to plasma membrane", "juxtamembrane", "plasma membrane lipid bilayer", "plasmalemma" ]

[ "NARROW", "EXACT", "EXACT", "EXACT", "NARROW", "NARROW", "NARROW", "BROAD", "NARROW", "EXACT" ]

[ "GO:0005887", "GO:0005904" ]

[ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_plant", "goslim_plant_ribbon", "goslim_prokaryote", "goslim_prokaryote_ribbon", "goslim_yeast" ]

[ "NIF_Subcellular:sao1663586795", "Wikipedia:Cell_membrane" ]

[ "GO:0016020" ]

[ "part_of GO:0071944" ]

[ "part_of" ]

[ "GO:0071944" ]

[ "GO:0016020", "GO:0071944" ]

[]

null

false

true

9

GO:0005888

5,888

obsolete proteoglycan integral to plasma membrane

cellular_component

OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer.

[ "GOC:curators" ]

This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product.

[ "proteoglycan integral to plasma membrane" ]

[ "EXACT" ]

[]

[ "GO:0005886" ]

[]

null

true

3

GO:0005890

5,890

sodium:potassium-exchanging ATPase complex

cellular_component

Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.

[ "ISBN:0198506732" ]

null

[ "sodium pump", "sodium/potassium-exchanging ATPase complex" ]

[ "BROAD", "EXACT" ]

[]

[ "GO:0090533", "GO:0098797" ]

[]

[ "GO:0090533", "GO:0098797" ]

[]

null

false

true

4

GO:0005891

5,891

voltage-gated calcium channel complex

cellular_component

A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.

[ "GOC:mah" ]

null

[ "voltage gated calcium channel complex", "voltage-dependent calcium channel complex", "voltage-sensitive calcium channel complex" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "goslim_pir" ]

[]

[ "GO:0034704", "GO:0098797" ]

[]

[ "GO:0034704", "GO:0098797" ]

[]

null

false

true

3

GO:0005892

5,892

acetylcholine-gated channel complex

cellular_component

A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.

[ "GOC:bf", "GOC:mah", "PMID:12381728", "PMID:15579462" ]

null

[ "nicotinic acetylcholine receptor", "nicotinic acetylcholine-gated receptor-channel complex" ]

[ "BROAD", "EXACT" ]

[]

[ "GO:0034702", "GO:0098802" ]

[]

[ "GO:0034702", "GO:0098802" ]

[]

null

false

true

2

GO:0005893

5,893

interleukin-2 receptor complex

cellular_component

A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits.

[ "GOC:mah", "PMID:3116143", "PMID:8266078" ]

null

[ "IL-2 receptor complex" ]

[ "EXACT" ]

[]

[ "GO:0098802" ]

[]

[ "GO:0098802" ]

[]

null

false

true

9

GO:0005894

5,894

interleukin-3 receptor complex

cellular_component

A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5.

[ "PMID:11839579" ]

null

[ "IL-3 receptor complex" ]

[ "EXACT" ]

[]

[ "GO:0098802" ]

[]

[ "GO:0098802" ]

[]

null

false

true

5

GO:0005895

5,895

interleukin-5 receptor complex

cellular_component

A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3.

[ "GOC:mah", "PMID:11312115", "PMID:11839579" ]

null

[ "IL-5 receptor complex" ]

[ "EXACT" ]

[]

[ "GO:0098802" ]

[]

[ "GO:0098802" ]

[]

null

false

true

2

GO:0005896

5,896

interleukin-6 receptor complex

cellular_component

A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130.

[ "PMID:8083235" ]

null

[ "IL-6 receptor complex" ]

[ "EXACT" ]

[]

[ "GO:0098802" ]

[]

[ "GO:0098802" ]

[]

null

false

true

9

GO:0005897

5,897

interleukin-9 receptor complex

cellular_component

A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins.

[ "GOC:mah", "PMID:10642536" ]

null

[ "IL-9 receptor complex" ]

[ "EXACT" ]

[]

[ "GO:0098802" ]

[]

[ "GO:0098802" ]

[]

null

false

true

3

GO:0005898

5,898

interleukin-13 receptor complex

cellular_component

A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain.

[ "PMID:8552669", "PMID:9013879" ]

null

[ "IL-13 receptor complex" ]

[ "EXACT" ]

[]

[ "GO:0098802" ]

[]

[ "GO:0098802" ]

[]

null

false

true

6

GO:0005899

5,899

insulin receptor complex

cellular_component

A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.

[ "ISBN:0198506732" ]

null

[]

[ "GO:0098802", "GO:1902911" ]

[]

[ "GO:0098802", "GO:1902911" ]

[]

null

false

true

6

GO:0005900

5,900

type I oncostatin-M receptor complex

cellular_component

A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta.

[ "GOC:jl", "PMID:8999038" ]

null

[ "oncostatin-M receptor complex" ]

[ "BROAD" ]

[]

[ "GO:0098802" ]

[]

[ "GO:0098802" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31369\" xsd:anyURI" ]

null

false

true

3

GO:0005901

5,901

caveola

cellular_component

A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppi...

[ "GOC:mah", "ISBN:0721662544", "PMID:16645198" ]

null

[ "caveolae", "caveolar membrane" ]

[ "EXACT", "RELATED" ]

[ "GO:0016599" ]

[]

[ "Wikipedia:Caveolae" ]

[ "GO:0044853" ]

[]

[ "GO:0044853" ]

[]

null

false

true

3

GO:0005903

5,903

brush border

cellular_component

The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

[ "GOC:sl", "ISBN:0815316194" ]

null

[]

[ "goslim_pir" ]

[ "Wikipedia:Brush_border" ]

[ "GO:0098862" ]

[ "has_part GO:0005902", "part_of GO:0045177" ]

[ "has_part", "part_of" ]

[ "GO:0005902", "GO:0045177" ]

[ "GO:0005902", "GO:0045177", "GO:0098862" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29939\" xsd:anyURI" ]

null

false

true

8

GO:0005905

5,905

clathrin-coated pit

cellular_component

A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and oth...

[ "GOC:mah", "ISBN:0198506732", "NIF_Subcellular:sao1969557946", "PMID:10559856", "PMID:17284835" ]

null

[ "coated pit" ]

[ "EXACT" ]

[]

[ "NIF_Subcellular:sao1969557946" ]

[ "GO:0016020" ]

[ "part_of GO:0012505" ]

[ "part_of" ]

[ "GO:0012505" ]

[ "GO:0012505", "GO:0016020" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26136\" xsd:anyURI" ]

null

false

true

2

GO:0005906

5,906

obsolete clathrin adaptor

cellular_component

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:curators" ]

This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean.

[ "adaptin", "clathrin adaptor" ]

[ "RELATED", "EXACT" ]

[]

[ "GO:0030119" ]

[]

null

true

9

GO:0005907

5,907

obsolete HA1 clathrin adaptor

cellular_component

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:curators" ]

This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous.

[ "AP1", "HA1 clathrin adaptor" ]

[ "RELATED", "EXACT" ]

[]

[ "GO:0030121" ]

[]

null

true

8

GO:0005908

5,908

obsolete HA2 clathrin adaptor

cellular_component

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:curators" ]

This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous.

[ "AP2", "HA2 clathrin adaptor" ]

[ "RELATED", "EXACT" ]

[]

[ "GO:0030122" ]

[]

null

true

8

GO:0005911

5,911

cell-cell junction

cellular_component

A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.

[ "GOC:aruk", "GOC:bc", "GOC:dgh", "GOC:hb", "GOC:mah", "PMID:21422226", "PMID:28096264" ]

null

[ "cell-cell contact region", "cell-cell contact zone", "intercellular junction" ]

[ "BROAD", "BROAD", "EXACT" ]

[]

[ "NIF_Subcellular:sao1922892319" ]

[ "GO:0070161" ]

[]

[ "GO:0070161" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22122\" xsd:anyURI" ]

null

false

true

6

GO:0005914

5,914

spot adherens junction

cellular_component

A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens.

[ "PMID:11700298" ]

null

[ "dense plaque", "punctum adherens" ]

[ "BROAD", "EXACT" ]

[]

[ "GO:0005912" ]

[]

[ "GO:0005912" ]

[]

null

false

true

6

GO:0005915

5,915

zonula adherens

cellular_component

A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.

[ "ISBN:0815316208" ]

null

[ "adhesion belt", "belt desmosome", "intermediate junction", "zonula adhaerens" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "NIF_Subcellular:sao1400623473" ]

[ "GO:0005912" ]

[ "part_of GO:0043296" ]

[ "part_of" ]

[ "GO:0043296" ]

[ "GO:0005912", "GO:0043296" ]

[]

null

false

true

1

GO:0005916

5,916

fascia adherens

cellular_component

A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighbouring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes.

[ "GOC:aruk", "GOC:bc", "GOC:mtg_muscle", "PMID:11732910" ]

null

[]

[ "Wikipedia:Fascia_adherens" ]

[ "GO:0005911" ]

[ "part_of GO:0014704" ]

[ "part_of" ]

[ "GO:0014704" ]

[ "GO:0005911", "GO:0014704" ]

[]

null

false

true

7

GO:0005917

5,917

nephrocyte diaphragm

cellular_component

A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates.

[ "GOC:mtg_kidney_jan10", "GOC:sart", "PMID:18971929" ]

null

[ "nephrocyte junction" ]

[ "RELATED" ]

[]

[ "GO:0036056" ]

[]

[ "GO:0036056" ]

[]

null

false

true

2

GO:0005918

5,918

septate junction

cellular_component

A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods.

[ "ISBN:0815332181", "PMID:11700298", "PMID:12612641", "PMID:20795303", "PMID:28636800" ]

null

[ "septate desmosome" ]

[ "RELATED" ]

[]

[ "NIF_Subcellular:sao427941916" ]

[ "GO:0070160" ]

[ "part_of GO:0043296" ]

[ "part_of" ]

[ "GO:0043296" ]

[ "GO:0043296", "GO:0070160" ]

[]

null

false

true

3

GO:0005919

5,919

pleated septate junction

cellular_component

A septate junction in which regular arrays of electron-dense septae span the intermembrane space.

[ "PMID:11700298" ]

null

[ "pleated desmosome" ]

[ "RELATED" ]

[]

[ "GO:0005918" ]

[]

[ "GO:0005918" ]

[]

null

false

true

8

GO:0005921

5,921

gap junction

cellular_component

A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins.

[ "GOC:mah", "GOC:mtg_muscle", "ISBN:0815332181", "PMID:22366062", "Wikipedia:Gap_junction" ]

null

[ "communicating junction", "electrical synapse", "electrotonic synapse", "gap junction macula", "gap junction plaque", "intercellular gap junction channel", "macula communicans", "zonula communicans" ]

[ "EXACT", "RELATED", "RELATED", "EXACT", "EXACT", "RELATED", "EXACT", "EXACT" ]

[]

[ "NIF_Subcellular:sao118541872", "Wikipedia:Gap_junction" ]

[ "GO:0005911" ]

[]

[ "GO:0005911" ]

[]

null

false

true

8

GO:0005922

5,922

connexin complex

cellular_component

An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.

[ "PMID:11146276" ]

null

[ "connexon", "connexon complex" ]

[ "EXACT", "RELATED" ]

[]

[ "NIF_Subcellular:sao445019788" ]

[ "GO:0098797" ]

[ "part_of GO:0005921" ]

[ "part_of" ]

[ "GO:0005921" ]

[ "GO:0005921", "GO:0098797" ]

[]

null

false

true

9

GO:0005923

5,923

bicellular tight junction

cellular_component

An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is com...

[ "GOC:mah", "ISBN:0815332181" ]

null

[ "zonula occludens" ]

[ "EXACT" ]

[]

[ "NIF_Subcellular:sao1939999134", "Wikipedia:Tight_junction" ]

[ "GO:0070160" ]

[ "part_of GO:0043296" ]

[ "part_of" ]

[ "GO:0043296" ]

[ "GO:0043296", "GO:0070160" ]

[]

null

false

true

5

GO:0005924

5,924

obsolete cell-substrate adherens junction

cellular_component

OBSOLETE. An adherens junction which connects a cell to the extracellular matrix.

[ "GOC:hb" ]

The reason for obsoletion is that, based on the most recent literature, there is no such structure in biology as 'cell-substrate adherens junction'. An 'adherens junction' is always a 'cell-cell junction' (PMIDs: 20571587, 17854762, 21422226, 28096264, 28401269, 26923917).

[ "hemi-adherens junction" ]

[ "RELATED" ]

[]

null

true

8

GO:0005925

5,925

focal adhesion

cellular_component

A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ).

[ "GOC:aruk", "GOC:bc", "ISBN:0124325653", "ISBN:0815316208", "PMID:10419689", "PMID:12191915", "PMID:15246682", "PMID:1643657", "PMID:16805308", "PMID:19197329", "PMID:23033047", "PMID:26923917", "PMID:28796323", "PMID:8314002" ]

null

[ "adhesion plaque", "connecting hemi-adherens junction", "focal contact", "HAJ", "hemi-adherens junction" ]

[ "RELATED", "EXACT", "EXACT", "EXACT", "EXACT" ]

[ "GO:0005926", "GO:0008357" ]

[]

[ "Wikipedia:Focal_adhesion" ]

[ "GO:0030055" ]

[]

[ "GO:0030055" ]

[]

null

false

true

6

GO:0005927

5,927

muscle tendon junction

cellular_component

A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons.

[ "GOC:mtg_muscle", "PMID:12842007" ]

null

[ "myotendinous junction" ]

[ "EXACT" ]

[]

[ "GO:0030055" ]

[]

[ "GO:0030055" ]

[]

null

false

true

2

GO:0005928

5,928

obsolete apical hemi-adherens junction

cellular_component

OBSOLETE. A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle.

[ "GOC:mah", "PMID:11700298" ]

The reason for obsoletion is that this term has not been used for GO annotation at all since 2001 when it was created, it has no children, it is not a part of any subset/slim.

[ "apical cell-substrate adherens junction", "apical dense plaque" ]

[ "EXACT", "EXACT" ]

[]

null

true

4

GO:0005929

5,929

cilium

cellular_component

A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.

[ "GOC:cilia", "GOC:curators", "GOC:kmv", "GOC:vw", "ISBN:0198547684", "PMID:16824949", "PMID:17009929", "PMID:20144998" ]

Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellular...

[ "eukaryotic flagellum", "flagellum", "microtubule-based flagellum", "primary cilium" ]

[ "EXACT", "RELATED", "EXACT", "NARROW" ]

[ "GO:0072372" ]

[ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pir" ]

[ "FMA:67181", "NIF_Subcellular:sao787716553", "Wikipedia:Cilium" ]

[ "GO:0043227", "GO:0120025" ]

[ "has_part GO:0030990" ]

[ "has_part" ]

[ "GO:0030990" ]

[ "GO:0030990", "GO:0043227", "GO:0120025" ]

[]

null

false

true

6

GO:0005930

5,930

axoneme

cellular_component

The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.

[ "GOC:bf", "GOC:cilia", "ISBN:0198547684" ]

Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane.

[ "ciliary axoneme", "cilium axoneme", "flagellar axoneme", "flagellum axoneme" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[ "GO:0035085", "GO:0035086" ]

[ "goslim_pir" ]

[ "Wikipedia:Axoneme" ]

[ "GO:0110165" ]

[ "has_part GO:0005874", "part_of GO:0005856", "part_of GO:0097014" ]

[ "has_part", "part_of", "part_of" ]

[ "GO:0005874", "GO:0005856", "GO:0097014" ]

[ "GO:0005856", "GO:0005874", "GO:0097014", "GO:0110165" ]

[]

null

false

true

8

GO:0005931

5,931

axonemal nexin link

cellular_component

A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules.

[ "GOC:cilia", "GOC:krc", "ISBN:0198506732", "PMID:21586547", "PMID:21728999", "PMID:22683354", "PMID:9295136" ]

null

[ "axonemal interdoublet link", "nexin complex" ]

[ "EXACT", "BROAD" ]

[]

[ "GO:0032991" ]

[ "part_of GO:0005930" ]

[ "part_of" ]

[ "GO:0005930" ]

[ "GO:0005930", "GO:0032991" ]

[]

null

false

true

6

GO:0005934

5,934

cellular bud tip

cellular_component

The end of a cellular bud distal to the site of attachment to the mother cell.

[ "GOC:mah" ]

null

[]

[ "GO:0030427" ]

[ "part_of GO:0005933" ]

[ "part_of" ]

[ "GO:0005933" ]

[ "GO:0005933", "GO:0030427" ]

[]

null

false

true

7

GO:0005935

5,935

cellular bud neck

cellular_component

The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.

[ "GOC:mah" ]

null

[]

[ "GO:0030427" ]

[ "part_of GO:0005933" ]

[ "part_of" ]

[ "GO:0005933" ]

[ "GO:0005933", "GO:0030427" ]

[]

null

false

true

8

GO:0005936

5,936

obsolete shmoo

cellular_component

OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles.

[ "GOC:mah", "GOC:mcc" ]

This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'.

[ "shmoo" ]

[ "EXACT" ]

[]

[ "GO:0001400", "GO:0005937" ]

[]

null

true

6

GO:0005937

5,937

mating projection

cellular_component

The projection formed by unicellular fungi in response to mating pheromone.

[ "GOC:mcc" ]

null

[ "conjugation tube", "shmoo" ]

[ "NARROW", "NARROW" ]

[]

[ "goslim_pir" ]

[]

[ "GO:0120025" ]

[]

[ "GO:0120025" ]

[]

null

false

true

2

GO:0005938

5,938

cell cortex

cellular_component

The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.

[ "GOC:mah", "ISBN:0815316194" ]

null

[ "cell periphery", "ectoplasm", "peripheral cytoplasm" ]

[ "RELATED", "NARROW", "RELATED" ]

[]

[ "goslim_candida", "goslim_yeast" ]

[ "Wikipedia:Cell_cortex" ]

[ "GO:0005737" ]

[ "part_of GO:0071944" ]

[ "part_of" ]

[ "GO:0071944" ]

[ "GO:0005737", "GO:0071944" ]

[ "GO:0005737", "part_of GO:0071944" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26298\" xsd:anyURI" ]

null

false

true

1

GO:0005940

5,940

septin ring

cellular_component

A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell...

[ "GOC:krc", "GOC:mah", "PMID:16009555", "PMID:16151244" ]

null

[]

[ "GO:0030481" ]

[]

[ "Wikipedia:Septin_ring" ]

[ "GO:0032156" ]

[ "part_of GO:0005856", "part_of GO:0005938" ]

[ "part_of", "part_of" ]

[ "GO:0005856", "GO:0005938" ]

[ "GO:0005856", "GO:0005938", "GO:0032156" ]

[]

null

false

true

6

GO:0005941

5,941

obsolete unlocalized protein complex

cellular_component

OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products.

[ "GOC:ma" ]

This term was made obsolete because it was originally intended only as a temporary parent for protein complex terms for which no more specific parents had been found. This term no longer has any children: All protein complex terms are is_a 'protein complex ; GO:0043234' and nearly all have been placed under parents to ...

[ "unlocalized protein complex" ]

[ "EXACT" ]

[]

null

true

2

GO:0005942

5,942

phosphatidylinositol 3-kinase complex

cellular_component

A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic sub...

[ "GOC:bf", "PMID:24587488" ]

For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/

[ "1-phosphatidylinositol 3-kinase complex", "phosphoinositide 3-kinase complex", "PI3-kinase p85-subunit alpha- PI3-kinase p110 complex", "PI3K complex", "PIK3C3-PIK3R4 complex", "PIK3CA-PIK3R1 complex" ]

[ "EXACT", "EXACT", "NARROW", "EXACT", "NARROW", "NARROW" ]

[]

[ "goslim_pir" ]

[]

[ "GO:0061695", "GO:0098796" ]

[ "part_of GO:0019898" ]

[ "part_of" ]

[ "GO:0019898" ]

[ "GO:0019898", "GO:0061695", "GO:0098796" ]

[]

null

false

true

9

GO:0005943

5,943

phosphatidylinositol 3-kinase complex, class IA

cellular_component

A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 protei...

[ "PMID:9255069", "PMID:9759495" ]

null

[ "1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex", "1-phosphatidylinositol-4-phosphate kinase, class IA complex", "class IA PI3K complex", "phosphoinositide 3-kinase complex, class IA" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[ "GO:0035030" ]

[]

[ "GO:0097651" ]

[]

[ "GO:0097651" ]

[]

null

false

true

1

GO:0005945

5,945

6-phosphofructokinase complex

cellular_component

A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known.

[ "GOC:mah", "GOC:vw", "ISBN:0198506732" ]

null

[]

[ "GO:0061695" ]

[ "part_of GO:0005829" ]

[ "part_of" ]

[ "GO:0005829" ]

[ "GO:0005829", "GO:0061695" ]

[]

null

false

true

2

GO:0005946

5,946

alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)

cellular_component

A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has treha...

[ "PMID:9837904" ]

See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'.

[ "trehalose-6-phosphate synthase complex", "trehalose-6-phosphate synthase/phosphatase", "UDP-glucose-glucosephosphate glucosyltransferase complex" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:1990234" ]

[ "part_of GO:0005737" ]

[ "part_of" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:1990234" ]

[]

null

false

true

8

GO:0005947

5,947

obsolete mitochondrial alpha-ketoglutarate dehydrogenase complex

cellular_component

OBSOLETE. Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity.

[ "GOC:mah", "GOC:mtg_sensu" ]

The reason for obsoletion is that this term is equivalent to mitochondrial oxoglutarate dehydrogenase complex.

[ "2-oxoglutarate dehydrogenase complex" ]

[ "BROAD" ]

[]

[ "GO:0045252" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26122\" xsd:anyURI" ]

null

true

2

GO:0005948

5,948

acetolactate synthase complex

cellular_component

A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate.

[ "GOC:jl", "PMID:16458324", "PMID:8756689" ]

See also the molecular function term 'acetolactate synthase activity ; GO:0003984'.

[ "acetohydroxyacid synthase complex" ]

[ "EXACT" ]

[]

[ "GO:1990234" ]

[ "part_of GO:0005737" ]

[ "part_of" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:1990234" ]

[]

null

false

true

3

GO:0005949

5,949

obsolete aminoadipate-semialdehyde dehydrogenase complex

cellular_component

OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde.

[ "EC:1.2.1.31" ]

This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products.

[ "aminoadipate-semialdehyde dehydrogenase complex" ]

[ "EXACT" ]

[]

null

true

9

GO:0005950

5,950

anthranilate synthase complex

cellular_component

A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine.

[ "PMID:4886290" ]

null

[]

[ "MetaCyc:ANTHRANSYN-CPLX" ]

[ "GO:1902494" ]

[ "part_of GO:0005737" ]

[ "part_of" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:1902494" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21246\" xsd:anyURI" ]

null

false

true

2

GO:0005951

5,951

carbamoyl-phosphate synthase complex

cellular_component

A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.

[ "PMID:8626695" ]

Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term.

[ "arginine-specific carbamoyl phosphate synthetase complex", "carbamoyl phosphate synthase complex", "carbamoyl-phosphate synthase arginine-specific complex" ]

[ "NARROW", "EXACT", "NARROW" ]

[]

[ "GO:1902494" ]

[ "part_of GO:0005737" ]

[ "part_of" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:1902494" ]

[]

null

false

true

1

GO:0005952

5,952

cAMP-dependent protein kinase complex

cellular_component

An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.

[ "PMID:18178622" ]

null

[ "3',5' cAMP-dependent protein kinase complex", "3',5'-cAMP-dependent protein kinase complex", "adenosine 3',5'-cyclophosphate-dependent protein kinase complex", "cyclic AMP-dependent protein kinase complex", "PKA" ]

[ "EXACT", "EXACT", "EXACT", "EXACT", "RELATED" ]

[]

[ "GO:0140535", "GO:1902554" ]

[]

[ "GO:0140535", "GO:1902554" ]

[]

null

false

true

4

GO:0005953

5,953

CAAX-protein geranylgeranyltransferase complex

cellular_component

A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane.

[ "PMID:9781874" ]

null

[]

[ "GO:0140535", "GO:1990234" ]

[]

[ "GO:0140535", "GO:1990234" ]

[]

null

false

true

4

GO:0005954

5,954

calcium- and calmodulin-dependent protein kinase complex

cellular_component

An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.

[ "PMID:20668654" ]

null

[ "calcium/calmodulin-dependent protein kinase complex", "CAMK2", "CaMKII" ]

[ "EXACT", "EXACT", "RELATED" ]

[]

[ "GO:0140535", "GO:1902494" ]

[]

[ "GO:0140535", "GO:1902494" ]

[]

null

false

true

4

GO:0005955

5,955

calcineurin complex

cellular_component

A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin.

[ "PMID:26794871" ]

null

[ "calcium-dependent protein serine/threonine phosphatase complex", "protein phosphatase type 2B complex" ]

[ "NARROW", "EXACT" ]

[]

[ "GO:0008287", "GO:0140535" ]

[]

[ "GO:0008287", "GO:0140535" ]

[]

null

false

true

3

GO:0005956

5,956

protein kinase CK2 complex

cellular_component

A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein.

[ "GOC:mah", "PMID:10994779" ]

Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex.

[ "casein kinase II complex" ]

[ "EXACT" ]

[]

[ "GO:0140535", "GO:1902554" ]

[]

[ "GO:0140535", "GO:1902554" ]

[]

null

false

true

1

GO:0005957

5,957

obsolete debranching enzyme

cellular_component

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:jl" ]

This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex.

[ "debranching enzyme" ]

[ "EXACT" ]

[]

[ "GO:0043033" ]

[]

null

true

7

GO:0005958

5,958

DNA-dependent protein kinase-DNA ligase 4 complex

cellular_component

A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV.

[ "GOC:jl", "GOC:mah", "PMID:10854421", "PMID:12235392", "PMID:17072889" ]

null

[]

[ "GO:0005959" ]

[]

[ "GO:0070419", "GO:0140513" ]

[]

[ "GO:0070419", "GO:0140513" ]

[]

null

false

true

7

GO:0005960

5,960

glycine cleavage complex

cellular_component

A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T.

[ "GOC:mah" ]

null

[ "glycine cleavage system", "glycine decarboxylase complex", "glycine dehydrogenase (decarboxylating) complex", "glycine dehydrogenase complex (decarboxylating)", "glycine synthase complex" ]

[ "EXACT", "EXACT", "EXACT", "RELATED", "EXACT" ]

[ "GO:0005961", "GO:0070015" ]

[ "goslim_pir" ]

[ "Wikipedia:Glycine_decarboxylase_complex" ]

[ "GO:1990204", "GO:1990234" ]

[]

[ "GO:1990204", "GO:1990234" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28865\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30262\" xsd:anyURI" ]

null

false

true

5

GO:0005962

5,962

obsolete mitochondrial isocitrate dehydrogenase complex (NAD+)

cellular_component

OBSOLETE. Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity.

[ "GOC:mah", "GOC:mtg_sensu" ]

The reason for obsoletion is that this term is unnecessarily taxon-specific.

[]

[ "GO:0045242" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26882\" xsd:anyURI" ]

null

true

7

GO:0005963

5,963

magnesium-dependent protein serine/threonine phosphatase complex

cellular_component

An intracellular enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase.

[ "PMID:17517611", "PMID:22343722" ]

null

[]

[ "GO:0008287", "GO:0140535" ]

[]

[ "GO:0008287", "GO:0140535" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22450\" xsd:anyURI" ]

null

false

true

6

GO:0005964

5,964

phosphorylase kinase complex

cellular_component

An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a.

[ "PMID:1370475" ]

null

[]

[ "GO:1902554" ]

[ "part_of GO:0005737" ]

[ "part_of" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:1902554" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21246\" xsd:anyURI" ]

null

false

true

5

GO:0005965

5,965

protein farnesyltransferase complex

cellular_component

A protein complex that possesses protein farnesyltransferase activity.

[ "GOC:mah" ]

null

[]

[ "GO:1990234" ]

[ "part_of GO:0005737" ]

[ "part_of" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:1990234" ]

[]

null

false

true

6

GO:0005966

5,966

obsolete cyclic-nucleotide phosphodiesterase complex

cellular_component

OBSOLETE. An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide.

[ "EC:3.1.4.-" ]

This term was obsoleted because it described a homomer.

[ "photoreceptor cyclic-nucleotide phosphodiesterase complex" ]

[ "NARROW" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21246\" xsd:anyURI" ]

null

true

7

GO:0005967

5,967

obsolete mitochondrial pyruvate dehydrogenase complex

cellular_component

OBSOLETE. A mitochondrial complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic for...

[ "GOC:mtg_sensu", "ISBN:0471331309", "ISBN:0716720094" ]

This term is unnecessarily taxon-specific.

[ "pyruvate dehydrogenase complex (lipoamide)" ]

[ "BROAD" ]

[]

[ "GO:0045254" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26122\" xsd:anyURI" ]

null

true

4

GO:0005968

5,968

Rab-protein geranylgeranyltransferase complex

cellular_component

An protein-containing complex which catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein. In mammals it is composed of an alpha and a beta subunit, and associates with an accessory protein Rep (Rab escort protein).

[ "GOC:jl", "PMID:11886217" ]

null

[ "GGTase-II complex", "Rab geranylgeranyltransferase complex", "RabGGTase complex" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:1990234" ]

[ "part_of GO:0005737" ]

[ "part_of" ]

[ "GO:0005737" ]

[ "GO:0005737", "GO:1990234" ]

[]

null

false

true

4

GO:0005971

5,971

ribonucleoside-diphosphate reductase complex

cellular_component

An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor.

[ "PMID:10716984", "PMID:21336276" ]

null

[ "ribonucleotide reductase complex", "RNR complex" ]

[ "EXACT", "EXACT" ]

[]

[ "GO:1990204" ]

[ "part_of GO:0005829" ]

[ "part_of" ]

[ "GO:0005829" ]

[ "GO:0005829", "GO:1990204" ]

[]

null

false

true

2

GO:0005972

5,972

obsolete fibrinogen alpha chain

cellular_component

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:jl" ]

This term was made obsolete because it represents a single gene product and not a complex.

[ "fibrinogen alpha chain" ]

[ "EXACT" ]

[ "GO:0008005" ]

[]

[ "GO:0005577" ]

[]

null

true

8

GO:0005973

5,973

obsolete fibrinogen beta chain

cellular_component

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:jl" ]

This term was made obsolete because it represents a single gene product and not a complex.

[ "fibrinogen beta chain" ]

[ "EXACT" ]

[ "GO:0008006" ]

[]

[ "GO:0005577" ]

[]

null

true

5

GO:0005974

5,974

obsolete fibrinogen gamma chain

cellular_component

OBSOLETE. (Was not defined before being made obsolete).

[ "GOC:jl" ]

This term was made obsolete because it represents a single gene product and not a complex.

[ "fibrinogen gamma chain" ]

[ "EXACT" ]

[ "GO:0008007" ]

[]

[ "GO:0005577" ]

[]

null

true

8

GO:0005975

5,975

carbohydrate metabolic process

biological_process

The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

[ "GOC:mah", "ISBN:0198506732" ]

null

[ "carbohydrate metabolism" ]

[ "EXACT" ]

[ "GO:0044261", "GO:0044723" ]

[ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_plant_ribbon", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ]

[ "Wikipedia:Carbohydrate_metabolism" ]

[ "GO:0044238" ]

[]

[ "GO:0044238" ]

[]

[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22880\" xsd:anyURI" ]

jl

2012-10-23T15:40:34Z

false

true

4

GO:0005976

5,976

polysaccharide metabolic process

biological_process

The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.

[ "ISBN:0198547684" ]

null

[ "glycan metabolic process", "glycan metabolism", "multicellular organismal polysaccharide metabolic process", "polysaccharide metabolism" ]

[ "NARROW", "NARROW", "NARROW", "EXACT" ]

[ "GO:0044263" ]

[ "goslim_pir" ]

[]

[ "GO:0005975", "GO:0043170" ]

[]

[ "GO:0005975", "GO:0043170" ]

[]

null

false

true

2

GO:0005977

5,977

glycogen metabolic process

biological_process

The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.

[ "ISBN:0198506732" ]

null

[ "glycogen metabolism" ]

[ "EXACT" ]

[]

[ "Reactome:R-HSA-8982491 \"Glycogen metabolism\"" ]

[ "GO:0006112", "GO:0044042" ]

[]

[ "GO:0006112", "GO:0044042" ]

[]

null

false

true

6

GO:0005978

5,978

glycogen biosynthetic process

biological_process

The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.

[ "ISBN:0198506732" ]

null

[ "glycogen anabolism", "glycogen biosynthesis", "glycogen formation", "glycogen synthesis" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "MetaCyc:PWY-7900", "Reactome:R-HSA-3322077 \"Glycogen synthesis\"" ]

[ "GO:0005977", "GO:0009250" ]

[]

[ "GO:0005977", "GO:0009250" ]

[]

[ "skos:narrowMatch MetaCyc:PWY-7900", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27107\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28527\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28968\" xsd:any...

null

false

true

1

GO:0005979

5,979

regulation of glycogen biosynthetic process

biological_process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.

[ "GOC:curators" ]

null

[ "regulation of glycogen anabolism", "regulation of glycogen biosynthesis", "regulation of glycogen formation", "regulation of glycogen synthesis" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0010962", "GO:0070873" ]

[ "regulates GO:0005978" ]

[ "regulates" ]

[ "GO:0005978" ]

[ "GO:0005978", "GO:0010962", "GO:0070873" ]

[ "GO:0065007", "regulates GO:0005978" ]

[]

null

false

true

3

GO:0005980

5,980

glycogen catabolic process

biological_process

The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.

[ "ISBN:0198506732" ]

null

[ "glycogen breakdown", "glycogen catabolism", "glycogen degradation", "glycogenolysis" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "MetaCyc:PWY-7662", "Reactome:R-HSA-70221 \"Glycogen breakdown (glycogenolysis)\"" ]

[ "GO:0005977", "GO:0009251" ]

[]

[ "GO:0005977", "GO:0009251" ]

[]

[ "skos:narrowMatch MetaCyc:PWY-7662", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27107\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28527\" xsd:anyURI" ]

null

false

true

6

GO:0005981

5,981

regulation of glycogen catabolic process

biological_process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen.

[ "GOC:curators" ]

null

[ "regulation of glycogen breakdown", "regulation of glycogen catabolism", "regulation of glycogen degradation", "regulation of glycogenolysis" ]

[ "EXACT", "EXACT", "EXACT", "EXACT" ]

[]

[ "GO:0043470", "GO:0070873" ]

[ "regulates GO:0005980" ]

[ "regulates" ]

[ "GO:0005980" ]

[ "GO:0005980", "GO:0043470", "GO:0070873" ]

[ "GO:0065007", "regulates GO:0005980" ]

[]

null

false

true

5

GO:0005982

5,982

starch metabolic process

biological_process

The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose.

[ "ISBN:0198506732" ]

null

[ "starch metabolism" ]

[ "EXACT" ]

[]

[ "GO:0044042" ]

[]

[ "GO:0044042" ]

[]

null

false

true

3

GO:0005983

5,983

starch catabolic process

biological_process

The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants.

[ "GOC:ai" ]

null

[ "starch breakdown", "starch catabolism", "starch degradation" ]

[ "EXACT", "EXACT", "EXACT" ]

[]

[ "MetaCyc:PWY-6724", "MetaCyc:PWY-6731", "MetaCyc:PWY-6735", "MetaCyc:PWY-6737", "MetaCyc:PWY-842" ]

[ "GO:0005982", "GO:0009251" ]

[]

[ "GO:0005982", "GO:0009251" ]

[]

[ "skos:narrowMatch MetaCyc:PWY-6724", "skos:narrowMatch MetaCyc:PWY-6731", "skos:narrowMatch MetaCyc:PWY-6735", "skos:narrowMatch MetaCyc:PWY-6737", "skos:narrowMatch MetaCyc:PWY-842", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31634\" xsd:anyURI" ]

null

false

true

6

GO:0005984

5,984

disaccharide metabolic process

biological_process

The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units.

[ "GOC:jl", "ISBN:0192800981" ]

null

[ "disaccharide metabolism" ]

[ "EXACT" ]

[]

[ "GO:0009311" ]

[]

[ "GO:0009311" ]

[]

null

false

true

1

GO:0005985

5,985

sucrose metabolic process

biological_process

The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside.

[ "GOC:curators" ]

null

[ "sucrose metabolism" ]

[ "EXACT" ]

[]

[ "GO:0005984" ]

[]

[ "GO:0005984" ]

[]

null

false

true

8