Datasets:
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GO

Dataset card Data Studio Files
xet
 Community
go_id
string
go_numeric_id
int64
name
string
namespace
string
definition
string
definition_xrefs
list
comment
string
synonyms
list
synonym_scopes
list
alt_ids
list
subsets
list
xrefs
list
is_a_ids
list
relationship_edges
list
relationship_types
list
relationship_target_ids
list
parent_ids
list
intersection_of
list
union_of
list
disjoint_from
list
replaced_by
list
consider
list
property_values
list
created_by
string
creation_date
string
is_obsolete
bool
in_go_basic
bool
split_bucket
int64
GO:0006223
6,223
uracil salvage
biological_process
Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis.
[ "GOC:jl" ]
null
[]
[]
[]
[]
[]
[ "GO:0043100", "GO:0046107" ]
[]
[]
[]
[ "GO:0043100", "GO:0046107" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006225
6,225
UDP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate.
[ "ISBN:0198506732" ]
null
[ "UDP anabolism", "UDP biosynthesis", "UDP formation", "UDP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009194", "GO:0009220", "GO:0046048" ]
[]
[]
[]
[ "GO:0009194", "GO:0009220", "GO:0046048" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006227
6,227
dUDP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate).
[ "ISBN:0198506732" ]
null
[ "dUDP anabolism", "dUDP biosynthesis", "dUDP formation", "dUDP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009197", "GO:0009221", "GO:0046077" ]
[]
[]
[]
[ "GO:0009197", "GO:0009221", "GO:0046077" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0006228
6,228
UTP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate.
[ "ISBN:0198506732" ]
null
[ "UTP anabolism", "UTP biosynthesis", "UTP formation", "UTP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009209", "GO:0009220", "GO:0046051" ]
[]
[]
[]
[ "GO:0009209", "GO:0009220", "GO:0046051" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006229
6,229
dUTP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate.
[ "ISBN:0198506732" ]
null
[ "dUTP anabolism", "dUTP biosynthesis", "dUTP formation", "dUTP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009212", "GO:0009221", "GO:0046080" ]
[]
[]
[]
[ "GO:0009212", "GO:0009221", "GO:0046080" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006230
6,230
TMP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate.
[ "ISBN:0198506732" ]
null
[ "TMP anabolism", "TMP biosynthesis", "TMP formation", "TMP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009174", "GO:0009220", "GO:0046044" ]
[]
[]
[]
[ "GO:0009174", "GO:0009220", "GO:0046044" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006231
6,231
dTMP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).
[ "ISBN:0198506732" ]
null
[ "dTMP anabolism", "dTMP biosynthesis", "dTMP formation", "dTMP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009177", "GO:0009221", "GO:0046073" ]
[]
[]
[]
[ "GO:0009177", "GO:0009221", "GO:0046073" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0006232
6,232
TDP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate.
[ "ISBN:0198506732" ]
null
[ "TDP anabolism", "TDP biosynthesis", "TDP formation", "TDP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009194", "GO:0009220", "GO:0046043" ]
[]
[]
[]
[ "GO:0009194", "GO:0009220", "GO:0046043" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006233
6,233
dTDP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate).
[ "ISBN:0198506732" ]
null
[ "dTDP anabolism", "dTDP biosynthesis", "dTDP formation", "dTDP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009197", "GO:0009221", "GO:0046072" ]
[]
[]
[]
[ "GO:0009197", "GO:0009221", "GO:0046072" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006234
6,234
TTP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate.
[ "ISBN:0198506732" ]
null
[ "TTP anabolism", "TTP biosynthesis", "TTP formation", "TTP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009209", "GO:0009220", "GO:0046046" ]
[]
[]
[]
[ "GO:0009209", "GO:0009220", "GO:0046046" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0006235
6,235
dTTP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.
[ "ISBN:0198506732" ]
null
[ "dTTP anabolism", "dTTP biosynthesis", "dTTP formation", "dTTP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009212", "GO:0009221", "GO:0046075" ]
[]
[]
[]
[ "GO:0009212", "GO:0009221", "GO:0046075" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0006236
6,236
obsolete cytidine salvage
biological_process
OBSOLETE. Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis.
[ "GOC:jl" ]
The reason for obsoletion is that there is no evidence that this process exists.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29724\" xsd:anyURI" ]
null
null
true
true
4
GO:0006237
6,237
deoxycytidine salvage
biological_process
Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis.
[ "GOC:jl" ]
null
[]
[]
[]
[]
[]
[ "GO:0043099", "GO:0046093" ]
[]
[]
[]
[ "GO:0043099", "GO:0046093" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0006238
6,238
CMP salvage
biological_process
Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis.
[ "GOC:jl" ]
null
[ "cytidine monophosphate salvage" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0009224", "GO:0010138" ]
[]
[]
[]
[ "GO:0009224", "GO:0010138" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006239
6,239
dCMP salvage
biological_process
Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis.
[ "GOC:jl" ]
null
[ "deoxycytidine monophosphate salvage" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0010139", "GO:0046064" ]
[]
[]
[]
[ "GO:0010139", "GO:0046064" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006240
6,240
dCDP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate.
[ "ISBN:0198506732" ]
null
[ "dCDP anabolism", "dCDP biosynthesis", "dCDP formation", "dCDP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009197", "GO:0009221", "GO:0046062" ]
[]
[]
[]
[ "GO:0009197", "GO:0009221", "GO:0046062" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006241
6,241
CTP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate.
[ "ISBN:0198506732" ]
null
[ "CTP anabolism", "CTP biosynthesis", "CTP formation", "CTP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009209", "GO:0009220", "GO:0046036" ]
[]
[]
[]
[ "GO:0009209", "GO:0009220", "GO:0046036" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006242
6,242
dCTP biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate.
[ "ISBN:0198506732" ]
null
[ "dCTP anabolism", "dCTP biosynthesis", "dCTP formation", "dCTP synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009212", "GO:0009221", "GO:0046065" ]
[]
[]
[]
[ "GO:0009212", "GO:0009221", "GO:0046065" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006244
6,244
pyrimidine nucleotide catabolic process
biological_process
The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
[ "GOC:curators", "ISBN:0198506732" ]
null
[ "pyrimidine nucleotide breakdown", "pyrimidine nucleotide catabolism", "pyrimidine nucleotide degradation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0006220", "GO:0009166", "GO:0072529" ]
[]
[]
[]
[ "GO:0006220", "GO:0009166", "GO:0072529" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006245
6,245
TDP catabolic process
biological_process
The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate.
[ "ISBN:0198506732" ]
null
[ "TDP breakdown", "TDP catabolism", "TDP degradation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009195", "GO:0009222", "GO:0046043" ]
[]
[]
[]
[ "GO:0009195", "GO:0009222", "GO:0046043" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0006246
6,246
dTDP catabolic process
biological_process
The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate.
[ "ISBN:0198506732" ]
null
[ "dTDP breakdown", "dTDP catabolism", "dTDP degradation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009198", "GO:0009223", "GO:0046072" ]
[]
[]
[]
[ "GO:0009198", "GO:0009223", "GO:0046072" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006247
6,247
obsolete TTP reduction
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it represents a molecular function rather than a biological process.
[ "TTP reduction" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0008998" ]
[]
null
null
true
true
3
GO:0006248
6,248
CMP catabolic process
biological_process
The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate.
[ "ISBN:0198506732" ]
null
[ "CMP breakdown", "CMP catabolism", "CMP degradation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009175", "GO:0009222", "GO:0046035" ]
[]
[]
[]
[ "GO:0009175", "GO:0009222", "GO:0046035" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006249
6,249
dCMP catabolic process
biological_process
The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate.
[ "ISBN:0198506732" ]
null
[ "dCMP breakdown", "dCMP catabolism", "dCMP degradation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009178", "GO:0009223", "GO:0046063" ]
[]
[]
[]
[ "GO:0009178", "GO:0009223", "GO:0046063" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006250
6,250
obsolete CDP reduction
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it represents a molecular function rather than a biological process.
[ "CDP reduction" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0051063" ]
[]
null
null
true
true
3
GO:0006251
6,251
dCDP catabolic process
biological_process
The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate.
[ "ISBN:0198506732" ]
null
[ "dCDP breakdown", "dCDP catabolism", "dCDP degradation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009198", "GO:0009223", "GO:0046062" ]
[]
[]
[]
[ "GO:0009198", "GO:0009223", "GO:0046062" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006252
6,252
obsolete CTP reduction
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it represents a molecular function rather than a biological process.
[ "CTP reduction" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0008998" ]
[]
null
null
true
true
2
GO:0006253
6,253
dCTP catabolic process
biological_process
The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate.
[ "ISBN:0198506732" ]
null
[ "dCTP breakdown", "dCTP catabolism", "dCTP degradation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009213", "GO:0009223", "GO:0046065" ]
[]
[]
[]
[ "GO:0009213", "GO:0009223", "GO:0046065" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006255
6,255
obsolete UDP reduction
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it represents a molecular function rather than a biological process.
[ "UDP reduction" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0051062" ]
[]
null
null
true
true
4
GO:0006256
6,256
UDP catabolic process
biological_process
The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate.
[ "ISBN:0198506732" ]
null
[ "UDP breakdown", "UDP catabolism", "UDP degradation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0009195", "GO:0009222", "GO:0046048" ]
[]
[]
[]
[ "GO:0009195", "GO:0009222", "GO:0046048" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006258
6,258
obsolete UDP-alpha-D-glucose catabolic process
biological_process
OBSOLETE. The chemical reactions and pathways resulting in the breakdown of UDP-alpha-D-glucose, a substance composed of UDP-alpha-D-glucose in glycosidic linkage with uridine diphosphate.
[ "GOC:ai" ]
The reason for obsoletion is that this term is not clearly defined.
[ "UDP-glucose breakdown", "UDP-glucose catabolism", "UDP-glucose conversion", "UDP-glucose degradation" ]
[ "EXACT", "EXACT", "RELATED", "EXACT" ]
[ "GO:0019691" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28951\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30685\" xsd:anyURI" ]
null
null
true
true
9
GO:0006259
6,259
DNA metabolic process
biological_process
Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
[ "ISBN:0198506732" ]
null
[ "cellular DNA metabolism", "DNA metabolism" ]
[ "EXACT", "EXACT" ]
[ "GO:0055132" ]
[ "goslim_agr", "goslim_candida", "goslim_chembl", "goslim_flybase_ribbon", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_plant_ribbon", "goslim_prokaryote_ribbon" ]
[]
[ "GO:0090304" ]
[]
[]
[]
[ "GO:0090304" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006260
6,260
DNA replication
biological_process
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topol...
[ "GOC:mah" ]
DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'.
[]
[]
[ "GO:0055133" ]
[ "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ]
[ "Reactome:R-HSA-176187 \"Activation of ATR in response to replication stress\"", "Reactome:R-HSA-69239 \"Synthesis of DNA\"", "Wikipedia:DNA_replication" ]
[ "GO:0006259" ]
[ "has_part GO:0071897" ]
[ "has_part" ]
[ "GO:0071897" ]
[ "GO:0006259", "GO:0071897" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/10596\" xsd:anyURI" ]
null
null
false
true
9
GO:0006261
6,261
DNA-templated DNA replication
biological_process
A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
[ "GOC:mah", "ISBN:0198506732" ]
null
[ "DNA-dependent DNA replication" ]
[ "EXACT" ]
[ "GO:0006262", "GO:0006263" ]
[]
[ "Reactome:R-HSA-69306 \"DNA Replication\"" ]
[ "GO:0006260" ]
[]
[]
[]
[ "GO:0006260" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22572\" xsd:anyURI" ]
null
null
false
true
2
GO:0006264
6,264
mitochondrial DNA replication
biological_process
The process in which new strands of DNA are synthesized in the mitochondrion.
[ "GOC:ai" ]
null
[ "mitochondrial DNA synthesis", "mtDNA replication", "mtDNA synthesis", "replication of mitochondrial DNA" ]
[ "RELATED", "EXACT", "RELATED", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-9913635 \"Strand-asynchronous mitochondrial DNA replication\"" ]
[ "GO:0006261", "GO:0032042" ]
[]
[]
[]
[ "GO:0006261", "GO:0032042" ]
[ "GO:0006260", "occurs_in GO:0005739" ]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0006265
6,265
DNA topological change
biological_process
The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
[ "ISBN:071673706X", "ISBN:0935702490" ]
Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0...
[ "DNA underwinding" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0006259", "GO:0071103" ]
[]
[]
[]
[ "GO:0006259", "GO:0071103" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0006266
6,266
obsolete DNA ligation
biological_process
OBSOLETE. The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.
[ "ISBN:0815316194" ]
The reason for obsoletion is that the term represents a molecular function.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29219\" xsd:anyURI" ]
null
null
true
true
8
GO:0006269
6,269
DNA replication, synthesis of primer
biological_process
The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synt...
[ "PMID:11395402", "PMID:38203225", "PMID:38492718" ]
null
[ "DNA priming", "DNA replication, synthesis of DNA primer", "DNA replication, synthesis of RNA primer", "replication priming" ]
[ "NARROW", "NARROW", "NARROW", "RELATED" ]
[]
[]
[]
[ "GO:0032774" ]
[ "part_of GO:0006261" ]
[ "part_of" ]
[ "GO:0006261" ]
[ "GO:0006261", "GO:0032774" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27176\" xsd:anyURI" ]
null
null
false
true
4
GO:0006270
6,270
DNA replication initiation
biological_process
The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.
[ "PMID:28209641" ]
null
[ "DNA endoreduplication initiation", "DNA re-replication initiation", "DNA-dependent DNA replication initiation" ]
[ "NARROW", "NARROW", "EXACT" ]
[ "GO:0042024" ]
[]
[ "Reactome:R-HSA-68952 \"DNA replication initiation\"", "Reactome:R-HSA-68962 \"Activation of the pre-replicative complex\"" ]
[ "GO:0006259" ]
[ "part_of GO:0006261" ]
[ "part_of" ]
[ "GO:0006261" ]
[ "GO:0006259", "GO:0006261" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/10596\" xsd:anyURI" ]
null
null
false
true
9
GO:0006271
6,271
DNA strand elongation involved in DNA replication
biological_process
The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication.
[ "GOC:mah", "ISBN:071673706X", "ISBN:0815316194" ]
null
[ "DNA replication elongation", "DNA strand elongation during DNA replication" ]
[ "EXACT", "RELATED" ]
[]
[]
[ "Reactome:R-HSA-69190 \"DNA strand elongation\"" ]
[ "GO:0022616" ]
[ "has_part GO:0090592", "part_of GO:0006261" ]
[ "has_part", "part_of" ]
[ "GO:0090592", "GO:0006261" ]
[ "GO:0006261", "GO:0022616", "GO:0090592" ]
[ "GO:0022616", "part_of GO:0006260" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/12633\" xsd:anyURI" ]
null
null
false
true
6
GO:0006273
6,273
lagging strand elongation
biological_process
The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of ...
[ "GOC:mah", "ISBN:071673706X", "ISBN:0815316194" ]
null
[]
[]
[]
[]
[]
[ "GO:0006271" ]
[ "has_part GO:0006269", "has_part GO:0043137" ]
[ "has_part", "has_part" ]
[ "GO:0006269", "GO:0043137" ]
[ "GO:0006269", "GO:0006271", "GO:0043137" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/12633\" xsd:anyURI" ]
null
null
false
true
5
GO:0006274
6,274
DNA replication termination
biological_process
The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet.
[ "GOC:mah", "PMID:10209736", "PMID:12009298" ]
null
[]
[]
[]
[]
[]
[ "GO:0006259" ]
[ "part_of GO:0006261" ]
[ "part_of" ]
[ "GO:0006261" ]
[ "GO:0006259", "GO:0006261" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0006275
6,275
regulation of DNA replication
biological_process
Any process that modulates the frequency, rate or extent of DNA replication.
[ "GOC:curators" ]
null
[]
[]
[]
[]
[]
[ "GO:0051052" ]
[ "regulates GO:0006260" ]
[ "regulates" ]
[ "GO:0006260" ]
[ "GO:0006260", "GO:0051052" ]
[ "GO:0065007", "regulates GO:0006260" ]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006276
6,276
plasmid maintenance
biological_process
The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division.
[ "GOC:ai" ]
null
[]
[]
[]
[ "goslim_pir" ]
[]
[ "GO:0009987" ]
[]
[]
[]
[ "GO:0009987" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0006277
6,277
DNA amplification
biological_process
The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment.
[ "ISBN:0721601464" ]
null
[]
[]
[]
[]
[]
[ "GO:0071897" ]
[]
[]
[]
[ "GO:0071897" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0006278
6,278
RNA-templated DNA biosynthetic process
biological_process
A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand.
[ "GOC:mah", "ISBN:0198506732" ]
null
[ "RNA-dependent DNA biosynthetic process" ]
[ "EXACT" ]
[]
[]
[ "Reactome:R-HSA-162589 \"Reverse Transcription of HIV RNA\"" ]
[ "GO:0071897" ]
[]
[]
[]
[ "GO:0071897" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006279
6,279
premeiotic DNA replication
biological_process
The replication of DNA that precedes meiotic cell division.
[ "GO_REF:0000060", "GOC:ai", "GOC:TermGenie" ]
null
[ "DNA replication during S phase involved in meiotic cell cycle", "DNA replication involved in S phase involved in meiotic cell cycle", "DNA replication involved in S-phase involved in meiotic cell cycle", "meiotic cell cycle DNA replication", "meiotic DNA replication", "meiotic DNA synthesis", "meiotic ...
[ "RELATED", "EXACT", "EXACT", "EXACT", "RELATED", "RELATED", "EXACT", "EXACT", "RELATED" ]
[ "GO:1902968" ]
[]
[]
[ "GO:0033260", "GO:1903046" ]
[]
[]
[]
[ "GO:0033260", "GO:1903046" ]
[ "GO:0033260", "part_of GO:0051321" ]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006280
6,280
obsolete mutagenesis
biological_process
OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where ...
[ "ISBN:0198506732" ]
This term was made obsolete because mutagenesis is not a valid biological process in which gene products would normally participate. Rather, mutations arise from DNA replication errors or damage by an extrinsic agent.
[ "mutagenesis" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006281", "GO:0051276" ]
[]
null
null
true
true
2
GO:0006281
6,281
DNA repair
biological_process
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because ...
[ "PMID:11563486" ]
null
[]
[]
[]
[ "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_pir", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ]
[ "Reactome:R-HSA-73894 \"DNA Repair\"", "Wikipedia:DNA_repair" ]
[ "GO:0006259", "GO:0006974" ]
[]
[]
[]
[ "GO:0006259", "GO:0006974" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006282
6,282
regulation of DNA repair
biological_process
Any process that modulates the frequency, rate or extent of DNA repair.
[ "GOC:curators" ]
null
[]
[]
[]
[ "goslim_metagenomics" ]
[]
[ "GO:0051052", "GO:0080135" ]
[ "regulates GO:0006281" ]
[ "regulates" ]
[ "GO:0006281" ]
[ "GO:0006281", "GO:0051052", "GO:0080135" ]
[ "GO:0065007", "regulates GO:0006281" ]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006283
6,283
transcription-coupled nucleotide-excision repair
biological_process
The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by th...
[ "PMID:10197977", "PMID:11900249" ]
null
[ "TC-NER", "TCR", "transcription-coupled NER", "transcription-coupled repair" ]
[ "EXACT", "RELATED", "EXACT", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-6781827 \"Transcription-Coupled Nucleotide Excision Repair (TC-NER)\"" ]
[ "GO:0006289" ]
[]
[]
[]
[ "GO:0006289" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006284
6,284
base-excision repair
biological_process
In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
[ "ISBN:0815316194" ]
null
[ "BER" ]
[ "EXACT" ]
[]
[]
[ "Reactome:R-HSA-73884 \"Base Excision Repair\"", "Reactome:R-HSA-73930 \"Abasic sugar-phosphate removal via the single-nucleotide replacement pathway\"", "Wikipedia:Base_excision_repair" ]
[ "GO:0006281" ]
[]
[]
[]
[ "GO:0006281" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006285
6,285
base-excision repair, AP site formation
biological_process
The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to...
[ "ISBN:0815316194" ]
null
[]
[]
[]
[]
[ "Reactome:R-HSA-73929 \"Base-Excision Repair, AP Site Formation\"" ]
[ "GO:0006259" ]
[ "part_of GO:0006284" ]
[ "part_of" ]
[ "GO:0006284" ]
[ "GO:0006259", "GO:0006284" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006288
6,288
obsolete base-excision repair, DNA ligation
biological_process
OBSOLETE. The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair.
[ "ISBN:1550091131" ]
The reason for obsoletion is that the term represents a molecular function.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29219\" xsd:anyURI" ]
null
null
true
true
9
GO:0006289
6,289
nucleotide-excision repair
biological_process
A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including d...
[ "PMID:10197977" ]
Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair.
[ "intrastrand cross-link repair", "NER", "pyrimidine-dimer repair, DNA damage excision" ]
[ "RELATED", "EXACT", "EXACT" ]
[ "GO:0045001" ]
[]
[ "Reactome:R-HSA-5696398 \"Nucleotide Excision Repair\"", "Reactome:R-HSA-5696400 \"Dual Incision in GG-NER\"" ]
[ "GO:0006281" ]
[]
[]
[]
[ "GO:0006281" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006290
6,290
pyrimidine dimer repair
biological_process
The repair of UV-induced T-T, C-T and C-C dimers.
[ "ISBN:0815316194" ]
null
[]
[]
[]
[]
[]
[ "GO:0006281" ]
[]
[]
[]
[ "GO:0006281" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006291
6,291
obsolete pyrimidine-dimer repair, DNA damage excision
biological_process
OBSOLETE. The excision of damaged DNA during pyrimidine-dimer repair. A large multienzyme complex scans the DNA for a distortion in the double helix rather than for a specific base change. Once a bulky lesion is found, the phosphodiester backbone of the abnormal strand is cleaved on both sides of the distortion, and th...
[ "ISBN:0815316194" ]
This term was made obsolete because this process can be subdivided into multiple processes.
[ "pyrimidine-dimer repair, DNA damage excision" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006289" ]
[]
null
null
true
true
9
GO:0006292
6,292
obsolete pyrimidine-dimer repair, DNA damage recognition
biological_process
OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers.
[ "ISBN:0815316194" ]
This term was made obsolete because it is a substrate specific DNA repair process.
[ "pyrimidine-dimer repair, DNA damage recognition" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0000715", "GO:0000716" ]
[]
null
null
true
true
6
GO:0006293
6,293
nucleotide-excision repair, preincision complex stabilization
biological_process
The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of t...
[ "GOC:elh", "PMID:10197977" ]
null
[]
[]
[]
[]
[]
[ "GO:0031334" ]
[ "part_of GO:0006289" ]
[ "part_of" ]
[ "GO:0006289" ]
[ "GO:0006289", "GO:0031334" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006295
6,295
obsolete nucleotide-excision repair, DNA incision, 3'-to lesion
biological_process
OBSOLETE. The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage.
[ "GOC:elh", "PMID:10197977" ]
This term was obsoleted because it represents a molecular function.
[ "nucleotide-excision repair, DNA incision, 3' to lesion" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006289" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22883\" xsd:anyURI" ]
null
null
true
true
6
GO:0006296
6,296
obsolete nucleotide-excision repair, DNA incision, 5'-to lesion
biological_process
OBSOLETE. The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage.
[ "GOC:elh", "PMID:10197977" ]
This term was obsoleted because it represents a molecular function.
[ "nucleotide-excision repair, DNA incision, 5' to lesion" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006289" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22883\" xsd:anyURI" ]
null
null
true
true
1
GO:0006297
6,297
nucleotide-excision repair, DNA gap filling
biological_process
Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.
[ "ISBN:0815316194" ]
null
[]
[]
[]
[]
[ "Reactome:R-HSA-5696397 \"Gap-filling DNA repair synthesis and ligation in GG-NER\"" ]
[ "GO:0006259" ]
[ "part_of GO:0006289" ]
[ "part_of" ]
[ "GO:0006289" ]
[ "GO:0006259", "GO:0006289" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006298
6,298
mismatch repair
biological_process
A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies...
[ "ISBN:0198506732", "PMID:11687886" ]
null
[ "long patch mismatch repair system", "mismatch repair, MutL-like pathway", "MMR", "MutS/MutL/MutH pathway" ]
[ "NARROW", "RELATED", "EXACT", "RELATED" ]
[ "GO:0006300" ]
[]
[ "Reactome:R-HSA-5358508 \"Mismatch Repair\"", "Wikipedia:DNA_mismatch_repair" ]
[ "GO:0006281" ]
[]
[]
[]
[ "GO:0006281" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0006299
6,299
obsolete short patch mismatch repair system
biological_process
OBSOLETE. The repair of mismatched DNA where the gap to be repaired is only one nucleotide. DNA polymerase is the preferred polymerase in short patch repair, performing gap filling DNA synthesis and removal of the 5'-deoxyribose phosphate of the abasic site.
[ "PMID:10660619", "PMID:10878254" ]
This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair.
[ "short patch mismatch repair system" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006284", "GO:0006289" ]
[]
null
null
true
true
3
GO:0006301
6,301
DNA damage tolerance
biological_process
A process that promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA replication, thereby preventing replication fork stalling and allowing completion of DNA replication without removing the damage.
[ "PMID:18157158", "PMID:26322163", "PMID:31251805" ]
null
[ "postreplication DNA repair", "postreplication repair" ]
[ "EXACT", "EXACT" ]
[]
[]
[ "Wikipedia:Postreplication_repair" ]
[ "GO:0006259", "GO:0006974" ]
[ "part_of GO:0006260" ]
[ "part_of" ]
[ "GO:0006260" ]
[ "GO:0006259", "GO:0006260", "GO:0006974" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30692\" xsd:anyURI" ]
null
null
false
true
7
GO:0006302
6,302
double-strand break repair
biological_process
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
[ "GOC:elh" ]
Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'.
[]
[]
[]
[]
[ "Reactome:R-HSA-5693532 \"DNA Double-Strand Break Repair\"" ]
[ "GO:0006281" ]
[]
[]
[]
[ "GO:0006281" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0006305
6,305
obsolete DNA alkylation
biological_process
OBSOLETE. The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis.
[ "ISBN:0716735970" ]
This term was obsoleted because it represents a molecular function.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
1
GO:0006306
6,306
obsolete DNA methylation
biological_process
OBSOLETE. The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
[ "GOC:ems", "ISBN:0198506732" ]
This term was obsoleted because it represents a molecular function.
[]
[]
[]
[]
[ "Wikipedia:DNA_methylation" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0009008", "GO:0009307", "GO:0031507" ]
[]
null
null
true
true
1
GO:0006307
6,307
DNA alkylation repair
biological_process
The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases.
[ "PMID:10946226", "PMID:35543797" ]
null
[ "DNA dealkylation involved in DNA repair" ]
[ "RELATED" ]
[]
[]
[ "Reactome:R-HSA-5657655 \"MGMT-mediated DNA damage reversal\"", "Reactome:R-HSA-73943 \"Reversal of alkylation damage by DNA dioxygenases\"" ]
[ "GO:0006281" ]
[]
[]
[]
[ "GO:0006281" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/27258\" xsd:anyURI" ]
null
null
false
true
4
GO:0006308
6,308
DNA catabolic process
biological_process
The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined...
[ "GOC:curators", "ISBN:0198506732" ]
null
[ "DNA breakdown", "DNA catabolism", "DNA degradation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0006259", "GO:0141188" ]
[ "has_part GO:0004536" ]
[ "has_part" ]
[ "GO:0004536" ]
[ "GO:0004536", "GO:0006259", "GO:0141188" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0006309
6,309
apoptotic DNA fragmentation
biological_process
The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.
[ "GOC:dph", "GOC:mah", "GOC:mtg_apoptosis", "GOC:tb", "ISBN:0721639976", "PMID:15723341", "PMID:23379520" ]
DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence...
[ "chromatinolysis", "DNA catabolic process during apoptosis", "DNA catabolism during apoptosis", "DNA fragmentation", "DNA fragmentation involved in apoptotic nuclear change", "endonucleolytic DNA catabolic process involved in apoptosis" ]
[ "BROAD", "EXACT", "EXACT", "BROAD", "EXACT", "EXACT" ]
[ "GO:0008178" ]
[]
[ "Reactome:R-HSA-140342 \"Apoptosis induced DNA fragmentation\"" ]
[ "GO:0006308" ]
[ "part_of GO:0030262" ]
[ "part_of" ]
[ "GO:0030262" ]
[ "GO:0006308", "GO:0030262" ]
[ "GO:0006308", "part_of GO:0030262" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24396\" xsd:anyURI" ]
null
null
false
true
5
GO:0006310
6,310
DNA recombination
biological_process
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchrom...
[ "ISBN:0198506732" ]
null
[]
[]
[]
[ "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_pombe", "goslim_prokaryote", "goslim_yeast" ]
[]
[ "GO:0006259" ]
[]
[]
[]
[ "GO:0006259" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006311
6,311
meiotic gene conversion
biological_process
The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three co...
[ "ISBN:0815316194" ]
null
[ "gene conversion without reciprocal crossover" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0035822", "GO:0061982" ]
[]
[]
[]
[ "GO:0035822", "GO:0061982" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006312
6,312
mitotic recombination
biological_process
The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles.
[ "GOC:elh" ]
null
[]
[]
[]
[]
[ "Wikipedia:Mitotic_crossover" ]
[ "GO:0006310" ]
[]
[]
[]
[ "GO:0006310" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006313
6,313
DNA transposition
biological_process
A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
[ "ISBN:0198506732", "ISBN:1555812090", "PMID:26846462", "PMID:30416149", "PMID:32588192" ]
null
[ "Class II transposition", "transposition, DNA-mediated" ]
[ "EXACT", "EXACT" ]
[ "GO:0006317", "GO:0006318" ]
[]
[ "Wikipedia:Transposable_element", "Wikipedia:Transposase" ]
[ "GO:0006310", "GO:0032196" ]
[]
[]
[]
[ "GO:0006310", "GO:0032196" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23746\" xsd:anyURI" ]
null
null
false
true
7
GO:0006314
6,314
intron homing
biological_process
Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron.
[ "PMID:10487208" ]
null
[]
[]
[]
[]
[]
[ "GO:0006310" ]
[]
[]
[]
[ "GO:0006310" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0006315
6,315
homing of group II introns
biological_process
Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure.
[ "GOC:mcc", "ISBN:0716743663", "PMID:10487208" ]
null
[]
[]
[]
[]
[]
[ "GO:0006314" ]
[]
[]
[]
[ "GO:0006314" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0006316
6,316
movement of group I intron
biological_process
Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction.
[ "GOC:mcc", "ISBN:0716743663", "PMID:10487208" ]
null
[]
[]
[]
[]
[]
[ "GO:0006314" ]
[]
[]
[]
[ "GO:0006314" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006324
6,324
obsolete S phase-specific histone modification
biological_process
OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle.
[ "GOC:mah", "PMID:9990026" ]
This term was made obsolete because it represents a molecular function.
[ "S phase-specific histone modification", "S-phase-specific histone modification" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
4
GO:0006326
6,326
obsolete bent DNA binding
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it represents a molecular function and not a biological process.
[ "bent DNA binding" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0003681" ]
[]
[]
null
null
true
true
4
GO:0006327
6,327
obsolete random coil binding
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it represents a molecular function and not a biological process.
[ "random coil binding" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
3
GO:0006328
6,328
obsolete AT binding
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it represents a molecular function and not a biological process.
[ "AT binding" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0003680" ]
[]
[]
null
null
true
true
5
GO:0006329
6,329
obsolete satellite DNA binding
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it represents a molecular function and not a biological process.
[ "satellite DNA binding" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0003696" ]
[]
[]
null
null
true
true
6
GO:0006330
6,330
obsolete single-stranded DNA binding
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it represents a molecular function and not a biological process.
[ "single-stranded DNA binding" ]
[ "EXACT" ]
[ "GO:0006331", "GO:0006332" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0003697" ]
[]
[]
null
null
true
true
6
GO:0006335
6,335
DNA replication-dependent chromatin assembly
biological_process
The formation of nucleosomes on newly synthesized DNA, coupled to strand elongation.
[ "GOC:mah", "PMID:28053344" ]
null
[ "DNA replication-dependent chromatin organization", "DNA replication-dependent nucleosome assembly", "DNA replication-dependent nucleosome organisation", "DNA replication-dependent nucleosome organization" ]
[ "RELATED", "BROAD", "RELATED", "RELATED" ]
[ "GO:0034723" ]
[]
[]
[ "GO:0006325" ]
[]
[]
[]
[ "GO:0006325" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22130\" xsd:anyURI" ]
null
null
false
true
9
GO:0006337
6,337
nucleosome disassembly
biological_process
The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
[ "GOC:mah" ]
null
[]
[]
[]
[]
[]
[ "GO:0032986", "GO:0034728" ]
[]
[]
[]
[ "GO:0032986", "GO:0034728" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006338
6,338
chromatin remodeling
biological_process
A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.
[ "GOC:jid", "GOC:vw", "PMID:12042764", "PMID:12697820" ]
null
[ "ATP-dependent chromatin remodeling", "ATP-dependent chromatin remodelling", "chromatin modeling", "chromatin modelling", "chromatin remodelling" ]
[ "NARROW", "NARROW", "EXACT", "EXACT", "EXACT" ]
[ "GO:0043044" ]
[]
[]
[ "GO:0006325" ]
[]
[]
[]
[ "GO:0006325" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21732\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/21748\" xsd:anyURI" ]
null
null
false
true
3
GO:0006340
6,340
obsolete negative regulation of transcription of homeotic gene (Polycomb group)
biological_process
OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group.
[ "GOC:curators" ]
This term was made obsolete because it relates to a specific gene family rather than a process.
[ "negative regulation of transcription of homeotic gene (Polycomb group)" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0000122", "GO:0031507", "GO:0045815" ]
[]
null
null
true
true
6
GO:0006341
6,341
obsolete chromatin insulator sequence binding
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:jl" ]
This term was made obsolete because it represents a molecular function and not a biological process.
[ "chromatin insulator sequence binding" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0043035" ]
[]
[]
null
null
true
true
9
GO:0006346
6,346
DNA methylation-dependent constitutive heterochromatin formation
biological_process
Formation of constitutive heterochromatin by a pathway that includes methylation of genomic DNA such as CpG islands.
[ "GOC:mah" ]
null
[ "DNA methylation-dependent heterochromatin assembly", "DNA methylation-dependent heterochromatin formation", "methylation-dependent chromatin silencing", "methylation-dependent heterochromatic silencing" ]
[ "EXACT", "EXACT", "BROAD", "BROAD" ]
[]
[]
[]
[ "GO:0140719" ]
[]
[]
[]
[ "GO:0140719" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22047\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23553\" xsd:anyURI" ]
null
null
false
true
1
GO:0006349
6,349
obsolete regulation of gene expression by genomic imprinting
biological_process
OBSOLETE. An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between th...
[ "PMID:11498578", "PMID:31896690", "PMID:7502071" ]
This term was obsoleted because it represents the same concept as its parent, GO:0071514 genomic imprinting, also a regulatory process.
[ "regulation of gene expression by DNA imprinting", "regulation of gene expression by genetic imprinting" ]
[ "EXACT", "RELATED" ]
[]
[]
[ "Wikipedia:Genomic_imprinting" ]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0071514" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22217\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25567\" xsd:anyURI" ]
null
null
true
true
3
GO:0006351
6,351
DNA-templated transcription
biological_process
The synthesis of an RNA transcript from a DNA template.
[ "GOC:jl", "GOC:txnOH" ]
null
[ "bacterial transcription", "cellular transcription", "DNA-dependent transcription", "transcription", "transcription from bacterial-type RNA polymerase promoter", "transcription, DNA-dependent", "transcription, DNA-templated" ]
[ "NARROW", "BROAD", "EXACT", "BROAD", "NARROW", "EXACT", "EXACT" ]
[ "GO:0001121", "GO:0006350", "GO:0061018", "GO:0061022" ]
[ "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_metagenomics", "goslim_mouse", "goslim_pir", "goslim_pombe", "goslim_prokaryote", "goslim_prokaryote_ribbon" ]
[ "Reactome:R-HSA-2173793 \"Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer\"", "Reactome:R-HSA-74160 \"Gene expression (Transcription)\"", "Wikipedia:Transcription_(genetics)" ]
[ "GO:0032774" ]
[ "part_of GO:0010467" ]
[ "part_of" ]
[ "GO:0010467" ]
[ "GO:0010467", "GO:0032774" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14854\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/16737\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22258\" xsd:anyURI", "term_tracker_item \"https://gi...
null
null
false
true
2
GO:0006352
6,352
DNA-templated transcription initiation
biological_process
The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeated...
[ "GOC:jid", "GOC:txnOH", "PMID:18280161" ]
Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
[ "DNA-dependent RNA polymerase complex assembly at promoter", "DNA-dependent transcription, initiation", "DNA-templated transcription, initiation", "initiation of DNA-dependent transcription", "initiation of transcription, DNA-dependent", "transcription initiation factor activity", "transcription initiat...
[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "RELATED", "NARROW", "RELATED" ]
[ "GO:0001123" ]
[ "goslim_yeast" ]
[]
[ "GO:0032774" ]
[ "part_of GO:0006351" ]
[ "part_of" ]
[ "GO:0006351" ]
[ "GO:0006351", "GO:0032774" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI" ]
null
null
false
true
7
GO:0006353
6,353
DNA-templated transcription termination
biological_process
The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template.
[ "GOC:txnOH", "PMID:15020047", "PMID:18280161", "PMID:30978344" ]
null
[ "DNA-dependent transcription, termination", "DNA-templated transcription, termination", "termination of DNA-dependent transcription", "termination of transcription, DNA-dependent", "transcription termination factor activity", "transcription termination from bacterial-type RNA polymerase promoter", "tran...
[ "EXACT", "EXACT", "EXACT", "EXACT", "RELATED", "NARROW", "RELATED", "BROAD" ]
[ "GO:0001125" ]
[ "goslim_yeast" ]
[]
[ "GO:0032774" ]
[ "part_of GO:0006351" ]
[ "part_of" ]
[ "GO:0006351" ]
[ "GO:0006351", "GO:0032774" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI" ]
null
null
false
true
6
GO:0006354
6,354
DNA-templated transcription elongation
biological_process
The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.
[ "GOC:mah", "GOC:txnOH", "PMID:15020047", "PMID:18280161" ]
null
[ "DNA-dependent transcription, elongation", "DNA-templated transcription, elongation", "RNA elongation", "RNA elongation from bacterial-type RNA polymerase promoter", "transcription elongation from bacterial-type RNA polymerase promoter", "transcription elongation, DNA-dependent", "transcriptional elonga...
[ "EXACT", "EXACT", "BROAD", "NARROW", "NARROW", "EXACT", "EXACT" ]
[ "GO:0001124" ]
[ "goslim_pir", "goslim_yeast" ]
[]
[ "GO:0032774" ]
[ "part_of GO:0006351" ]
[ "part_of" ]
[ "GO:0006351" ]
[ "GO:0006351", "GO:0032774" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI" ]
null
null
false
true
2
GO:0006356
6,356
regulation of transcription by RNA polymerase I
biological_process
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I.
[ "GOC:curators" ]
null
[ "regulation of transcription from Pol I promoter", "regulation of transcription from RNA polymerase I promoter" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0006355" ]
[ "regulates GO:0006360" ]
[ "regulates" ]
[ "GO:0006360" ]
[ "GO:0006355", "GO:0006360" ]
[ "GO:0065007", "regulates GO:0006360" ]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006359
6,359
regulation of transcription by RNA polymerase III
biological_process
Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III.
[ "GOC:curators" ]
null
[ "regulation of transcription from Pol III promoter", "regulation of transcription from RNA polymerase III promoter" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0006355" ]
[ "regulates GO:0006383" ]
[ "regulates" ]
[ "GO:0006383" ]
[ "GO:0006355", "GO:0006383" ]
[ "GO:0065007", "regulates GO:0006383" ]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0006360
6,360
transcription by RNA polymerase I
biological_process
The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter.
[ "GOC:jl", "GOC:txnOH" ]
null
[ "RNA polymerase I transcription factor activity", "transcription from Pol I promoter", "transcription from RNA polymerase I promoter" ]
[ "RELATED", "EXACT", "EXACT" ]
[]
[ "goslim_yeast" ]
[ "Reactome:R-HSA-73864 \"RNA Polymerase I Transcription\"" ]
[ "GO:0006351" ]
[]
[]
[]
[ "GO:0006351" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14854\" xsd:anyURI" ]
null
null
false
true
1
GO:0006361
6,361
transcription initiation at RNA polymerase I promoter
biological_process
A transcription initiation process that takes place at a RNA polymerase I gene promoter. Ribosomal RNAs (rRNA) genes are transcribed by RNA polymerase I.
[ "GOC:txnOH" ]
Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
[ "transcription initiation from Pol I promoter", "transcription initiation from RNA polymerase I promoter", "transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript" ]
[ "EXACT", "EXACT", "NARROW" ]
[ "GO:0001180" ]
[]
[ "Reactome:R-HSA-73854 \"RNA Polymerase I Promoter Clearance\"" ]
[ "GO:0006352" ]
[ "part_of GO:0006360" ]
[ "part_of" ]
[ "GO:0006360" ]
[ "GO:0006352", "GO:0006360" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI" ]
krc
2011-08-15T03:45:49Z
false
true
6
GO:0006362
6,362
transcription elongation by RNA polymerase I
biological_process
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I.
[ "GOC:mah", "GOC:txnOH" ]
null
[ "RNA elongation from Pol I promoter", "RNA polymerase I transcription elongation factor activity", "transcription elongation from RNA polymerase I promoter", "transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript" ]
[ "EXACT", "RELATED", "EXACT", "RELATED" ]
[ "GO:0001183" ]
[]
[]
[ "GO:0006354" ]
[ "part_of GO:0006360" ]
[ "part_of" ]
[ "GO:0006360" ]
[ "GO:0006354", "GO:0006360" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31106\" xsd:anyURI" ]
null
null
false
true
8