Datasets:
LiteFold
/
GO

Dataset card Data Studio Files
xet
 Community
go_id
string
go_numeric_id
int64
name
string
namespace
string
definition
string
definition_xrefs
list
comment
string
synonyms
list
synonym_scopes
list
alt_ids
list
subsets
list
xrefs
list
is_a_ids
list
relationship_edges
list
relationship_types
list
relationship_target_ids
list
parent_ids
list
intersection_of
list
union_of
list
disjoint_from
list
replaced_by
list
consider
list
property_values
list
created_by
string
creation_date
string
is_obsolete
bool
in_go_basic
bool
split_bucket
int64
GO:0006363
6,363
termination of RNA polymerase I transcription
biological_process
A transcription termination process that completes the production of a ribosomal RNA transcript. RNAP I termination requires binding of a terminator protein to specific sequences downstream of the transcription unit.
[ "GOC:mah", "GOC:txnOH", "PMID:10684922", "PMID:27371117" ]
null
[ "RNA polymerase I transcription termination", "RNA polymerase I transcription termination factor activity", "termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript", "transcription termination from Pol I promoter", "transcription termination from RNA polymerase I promo...
[ "EXACT", "RELATED", "NARROW", "EXACT", "EXACT" ]
[ "GO:0001185", "GO:0019223" ]
[]
[ "Reactome:R-HSA-73863 \"RNA Polymerase I Transcription Termination\"" ]
[ "GO:0006353" ]
[ "part_of GO:0006360" ]
[ "part_of" ]
[ "GO:0006360" ]
[ "GO:0006353", "GO:0006360" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/12739\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI" ]
krc
2011-08-15T04:07:43Z
false
true
4
GO:0006364
6,364
rRNA processing
biological_process
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
[ "GOC:curators" ]
null
[ "35S primary transcript processing" ]
[ "NARROW" ]
[ "GO:0006365" ]
[ "goslim_yeast" ]
[ "Reactome:R-HSA-72312 \"rRNA processing\"" ]
[ "GO:0006396", "GO:0016072" ]
[ "part_of GO:0042254" ]
[ "part_of" ]
[ "GO:0042254" ]
[ "GO:0006396", "GO:0016072", "GO:0042254" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006366
6,366
transcription by RNA polymerase II
biological_process
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
[ "GOC:jl", "GOC:txnOH", "ISBN:0321000382" ]
null
[ "gene-specific transcription from RNA polymerase II promoter", "general transcription from RNA polymerase II promoter", "RNA polymerase II transcription factor activity", "specific transcription from RNA polymerase II promoter", "transcription from Pol II promoter", "transcription from RNA polymerase II p...
[ "RELATED", "RELATED", "RELATED", "RELATED", "EXACT", "EXACT" ]
[ "GO:0032568", "GO:0032569" ]
[ "goslim_yeast" ]
[ "Reactome:R-HSA-73857 \"RNA Polymerase II Transcription\"" ]
[ "GO:0006351" ]
[]
[]
[]
[ "GO:0006351" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14854\" xsd:anyURI" ]
null
null
false
true
2
GO:0006367
6,367
transcription initiation at RNA polymerase II promoter
biological_process
A transcription initiation process that takes place at a RNA polymerase II gene promoter. Messenger RNAs (mRNA) genes, as well as some non-coding RNAs, are transcribed by RNA polymerase II.
[ "GOC:mah", "GOC:txnOH" ]
Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
[ "transcription initiation from Pol II promoter", "transcription initiation from RNA polymerase II promoter" ]
[ "EXACT", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-167161 \"HIV Transcription Initiation\"", "Reactome:R-HSA-2032785 \"YAP1- and WWTR1 (TAZ)-stimulated gene expression\"", "Reactome:R-HSA-350054 \"Notch-HLH transcription pathway\"", "Reactome:R-HSA-383280 \"Nuclear Receptor transcription pathway\"", "Reactome:R-HSA-73779 \"RNA Polymerase II ...
[ "GO:0006352" ]
[ "part_of GO:0006366" ]
[ "part_of" ]
[ "GO:0006366" ]
[ "GO:0006352", "GO:0006366" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI" ]
null
null
false
true
1
GO:0006368
6,368
transcription elongation by RNA polymerase II
biological_process
The extension of an RNA molecule after transcription pausing and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
[ "GOC:mah", "GOC:txnOH" ]
null
[ "RNA elongation from Pol II promoter", "RNA polymerase II transcription elongation factor activity", "transcription elongation by RNA polymerase II promoter", "transcription elongation from RNA polymerase II promoter" ]
[ "EXACT", "RELATED", "EXACT", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-167169 \"HIV Transcription Elongation\"", "Reactome:R-HSA-73776 \"RNA Polymerase II Promoter Escape\"", "Reactome:R-HSA-75955 \"RNA Polymerase II Transcription Elongation\"" ]
[ "GO:0006354" ]
[ "part_of GO:0006366" ]
[ "part_of" ]
[ "GO:0006366" ]
[ "GO:0006354", "GO:0006366" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29529\" xsd:anyURI" ]
null
null
false
true
9
GO:0006369
6,369
termination of RNA polymerase II transcription
biological_process
A transcription termination process that completes the production of a primary RNA polymerase II transcript.
[ "GOC:mah", "GOC:txnOH", "PMID:27371117" ]
null
[ "RNA 3'-end formation by RNA polymerase II", "RNA polymerase II transcription termination", "RNA polymerase II transcription termination factor activity", "transcription termination from Pol II promoter", "transcription termination from RNA polymerase II promoter" ]
[ "EXACT", "EXACT", "RELATED", "EXACT", "EXACT" ]
[ "GO:0019224" ]
[]
[ "Reactome:R-HSA-73856 \"RNA Polymerase II Transcription Termination\"" ]
[ "GO:0006353" ]
[ "part_of GO:0006366" ]
[ "part_of" ]
[ "GO:0006366" ]
[ "GO:0006353", "GO:0006366" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/12739\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI" ]
null
null
false
true
7
GO:0006370
6,370
7-methylguanosine mRNA capping
biological_process
The sequence of enzymatic reactions by which the mRNA 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript. Additional methylation can occur on the ribose sugars of the first and second nucleotides adj...
[ "GOC:mah", "PMID:9266685" ]
null
[ "5' end capping", "5' mRNA capping", "5'-end mRNA processing", "5'-end processing", "mRNA capping" ]
[ "BROAD", "EXACT", "EXACT", "BROAD", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-72086 \"mRNA Capping\"" ]
[ "GO:0006397", "GO:0009452" ]
[]
[]
[]
[ "GO:0006397", "GO:0009452" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006371
6,371
obsolete mRNA splicing
biological_process
OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced.
[ "GOC:krc", "ISBN:0198506732" ]
This term was made obsolete because it represents several different processes.
[ "mRNA splicing" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0000372", "GO:0000373", "GO:0000374", "GO:0000394", "GO:0000398" ]
[]
null
null
true
true
5
GO:0006372
6,372
obsolete lariat formation, 5'-splice site cleavage
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:krc" ]
This term was made obsolete because it represents a molecular function.
[ "lariat formation, 5'-splice site cleavage" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0000350", "GO:0000386" ]
[]
null
null
true
true
9
GO:0006373
6,373
obsolete 3'-splice site cleavage, exon ligation
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:krc" ]
This term was made obsolete because it represents a molecular function.
[ "3'-splice site cleavage, exon ligation" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0000386", "GO:0000388", "GO:0000393" ]
[]
null
null
true
true
3
GO:0006376
6,376
mRNA splice site recognition
biological_process
Selection of a splice site by components of the assembling spliceosome.
[ "GOC:krc", "ISBN:0879695897" ]
null
[ "spliceosomal commitment complex biosynthesis", "spliceosomal commitment complex formation", "spliceosomal E complex biosynthesis", "spliceosomal E complex formation" ]
[ "NARROW", "NARROW", "NARROW", "NARROW" ]
[]
[]
[]
[ "GO:0022618" ]
[ "part_of GO:0000245" ]
[ "part_of" ]
[ "GO:0000245" ]
[ "GO:0000245", "GO:0022618" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25114\" xsd:anyURI" ]
null
null
false
true
5
GO:0006377
6,377
obsolete MATa1 (A1) pre-mRNA splicing
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:krc" ]
This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene.
[ "MATa1 (A1) pre-mRNA splicing" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0000244" ]
[]
null
null
true
true
5
GO:0006378
6,378
obsolete mRNA polyadenylation
biological_process
OBSOLETE. The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
[ "ISBN:0198506732" ]
The reason for obsoletion is that this term represents a molecular function.
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006397", "GO:0097222", "GO:0180010" ]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/24924\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26944\" xsd:anyURI" ]
null
null
true
true
7
GO:0006379
6,379
obsolete mRNA cleavage
biological_process
OBSOLETE. Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
[ "GOC:mah" ]
This term was obsoleted because it represents a molecular function
[ "cleavage stimulation factor activity" ]
[ "RELATED" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25185\" xsd:anyURI" ]
null
null
true
true
5
GO:0006380
6,380
obsolete poly-A binding
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators" ]
This term was made obsolete because it represents a molecular function and not a biological process.
[ "poly-A binding" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0008143" ]
[]
null
null
true
true
4
GO:0006382
6,382
adenosine to inosine editing
biological_process
The conversion of an adenosine residue to inosine in an RNA molecule by deamination.
[ "PMID:11092837" ]
null
[]
[]
[]
[]
[ "Reactome:R-HSA-75064 \"mRNA Editing: A to I Conversion\"" ]
[ "GO:0016553" ]
[]
[]
[]
[ "GO:0016553" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0006384
6,384
transcription initiation at RNA polymerase III promoter
biological_process
A transcription initiation process that takes place at a RNA polymerase III gene promoter. Transfer RNAs (tRNA) genes, as well as some other non-coding RNAs, are transcribed by RNA polymerase III.
[ "GOC:mah", "GOC:txnOH" ]
Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation.
[ "transcription initiation from Pol III promoter", "transcription initiation from RNA polymerase III hybrid type promoter", "transcription initiation from RNA polymerase III promoter", "transcription initiation from RNA polymerase III type 1 promoter", "transcription initiation from RNA polymerase III type 2...
[ "EXACT", "NARROW", "EXACT", "NARROW", "NARROW", "NARROW" ]
[ "GO:0001022", "GO:0001023", "GO:0001024", "GO:0001036" ]
[]
[]
[ "GO:0006352" ]
[ "part_of GO:0006383" ]
[ "part_of" ]
[ "GO:0006383" ]
[ "GO:0006352", "GO:0006383" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI" ]
krc
2010-08-19T04:33:52Z
false
true
8
GO:0006385
6,385
transcription elongation by RNA polymerase III
biological_process
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III.
[ "GOC:mah", "GOC:txnOH" ]
null
[ "RNA elongation from Pol III promoter", "RNA polymerase III transcription elongation factor activity", "transcription elongation by RNA polymerase III promoter", "transcription elongation from RNA polymerase III promoter" ]
[ "EXACT", "RELATED", "EXACT", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-73780 \"RNA Polymerase III Chain Elongation\"" ]
[ "GO:0006354" ]
[ "part_of GO:0006383" ]
[ "part_of" ]
[ "GO:0006383" ]
[ "GO:0006354", "GO:0006383" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI" ]
null
null
false
true
8
GO:0006386
6,386
termination of RNA polymerase III transcription
biological_process
A transcription termination process that completes the production of a primary RNA polymerase II transcript. RNA polymerase III has an intrinsic ability to terminate transcription upon incorporation of at least 4 contiguous U residues.
[ "GOC:mah", "PMID:12944462", "PMID:27371117" ]
null
[ "RNA polymerase III transcription termination", "RNA polymerase III transcription termination factor activity", "transcription termination from Pol III promoter", "transcription termination from RNA polymerase III promoter" ]
[ "EXACT", "RELATED", "EXACT", "EXACT" ]
[ "GO:0019225" ]
[]
[ "Reactome:R-HSA-73980 \"RNA Polymerase III Transcription Termination\"" ]
[ "GO:0006353" ]
[ "part_of GO:0006383" ]
[ "part_of" ]
[ "GO:0006383" ]
[ "GO:0006353", "GO:0006383" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/12739\" xsd:anyURI" ]
null
null
false
true
4
GO:0006387
6,387
obsolete snRNA capping
biological_process
OBSOLETE. The sequence of enzymatic reactions resulting in the addition of a cap to the 5' end of a nascent snRNA transcript.
[ "GOC:mah" ]
This term was made obsolete because it has been replaced with a more specific term to describe cap hypermethylation. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the 7-methyl-G cap is hypermethylated to become a 2,2,7-tri...
[ "snRNA capping" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0036261" ]
[]
null
null
true
true
2
GO:0006388
6,388
tRNA splicing, via endonucleolytic cleavage and ligation
biological_process
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
[ "GOC:krc", "ISBN:0879695897", "PMID:9582290" ]
Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis.
[ "tRNA-Y splicing" ]
[ "NARROW" ]
[]
[]
[]
[ "GO:0000394", "GO:0008033" ]
[]
[]
[]
[ "GO:0000394", "GO:0008033" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006389
6,389
obsolete tRNA-Y splicing
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:krc" ]
This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA.
[ "tRNA-Y splicing" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006388" ]
[]
null
null
true
true
2
GO:0006390
6,390
mitochondrial transcription
biological_process
The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.
[ "GOC:jl", "PMID:23632312" ]
null
[ "transcription from mitochondrial promoter" ]
[ "EXACT" ]
[]
[]
[ "Reactome:R-HSA-75944 \"Transcription from mitochondrial promoters\"" ]
[ "GO:0000959", "GO:0006351" ]
[ "part_of GO:0140053" ]
[ "part_of" ]
[ "GO:0140053" ]
[ "GO:0000959", "GO:0006351", "GO:0140053" ]
[ "GO:0006351", "occurs_in GO:0005739" ]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/14854\" xsd:anyURI" ]
null
null
false
true
4
GO:0006391
6,391
transcription initiation at mitochondrial promoter
biological_process
A transcription initiation process that takes place at a promoter on the mitochondrial chromosome.
[ "PMID:33127643" ]
null
[ "transcription initiation from mitochondrial promoter" ]
[ "EXACT" ]
[]
[]
[ "Reactome:R-HSA-163282 \"Mitochondrial transcription initiation\"" ]
[ "GO:0000959", "GO:0006352" ]
[ "part_of GO:0006390" ]
[ "part_of" ]
[ "GO:0006390" ]
[ "GO:0000959", "GO:0006352", "GO:0006390" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI" ]
null
null
false
true
3
GO:0006392
6,392
transcription elongation by mitochondrial RNA polymerase
biological_process
The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase.
[ "GOC:mah", "GOC:txnOH" ]
null
[ "RNA elongation from mitochondrial promoter", "transcription elongation from mitochondrial promoter" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0000959", "GO:0006354" ]
[ "part_of GO:0006390" ]
[ "part_of" ]
[ "GO:0006390" ]
[ "GO:0000959", "GO:0006354", "GO:0006390" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23386\" xsd:anyURI" ]
null
null
false
true
6
GO:0006396
6,396
RNA processing
biological_process
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
[ "GOC:mah" ]
null
[]
[]
[ "GO:0006394" ]
[ "goslim_drosophila", "goslim_pir" ]
[ "Wikipedia:Post-transcriptional_modification" ]
[ "GO:0044238" ]
[ "part_of GO:0010467", "part_of GO:0032774" ]
[ "part_of", "part_of" ]
[ "GO:0010467", "GO:0032774" ]
[ "GO:0010467", "GO:0032774", "GO:0044238" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006397
6,397
mRNA processing
biological_process
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
[ "GOC:mah" ]
null
[ "mRNA maturation" ]
[ "RELATED" ]
[]
[ "goslim_chembl", "goslim_yeast" ]
[]
[ "GO:0006396", "GO:0016071" ]
[]
[]
[]
[ "GO:0006396", "GO:0016071" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006399
6,399
tRNA metabolic process
biological_process
The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the func...
[ "ISBN:0198506732" ]
null
[ "tRNA metabolism" ]
[ "EXACT" ]
[]
[ "goslim_chembl", "goslim_drosophila", "goslim_generic", "goslim_pombe" ]
[]
[ "GO:0016070" ]
[]
[]
[]
[ "GO:0016070" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0006400
6,400
tRNA modification
biological_process
The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
[ "GOC:curators" ]
The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specifi...
[ "tRNA editing" ]
[ "NARROW" ]
[ "GO:0016549" ]
[]
[ "Reactome:R-HSA-6782315 \"tRNA modification in the nucleus and cytosol\"" ]
[ "GO:0008033", "GO:0009451" ]
[]
[]
[]
[ "GO:0008033", "GO:0009451" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006401
6,401
RNA catabolic process
biological_process
The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
[ "ISBN:0198506732" ]
null
[ "RNA breakdown", "RNA catabolism", "RNA degradation" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[ "goslim_yeast" ]
[ "Reactome:R-HSA-9930044 \"Nuclear RNA decay\"" ]
[ "GO:0016070", "GO:0141188" ]
[]
[]
[]
[ "GO:0016070", "GO:0141188" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0006402
6,402
mRNA catabolic process
biological_process
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
[ "ISBN:0198506732" ]
null
[ "mRNA breakdown", "mRNA catabolism", "mRNA decay", "mRNA degradation" ]
[ "EXACT", "EXACT", "RELATED", "EXACT" ]
[]
[]
[]
[ "GO:0006401", "GO:0010629", "GO:0016071" ]
[]
[]
[]
[ "GO:0006401", "GO:0010629", "GO:0016071" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006404
6,404
RNA import into nucleus
biological_process
The import of RNA from the cytoplasm to the nucleus.
[ "GOC:ma" ]
null
[ "RNA import into cell nucleus", "RNA transport from cytoplasm to nucleus", "RNA-nucleus import" ]
[ "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0050658", "GO:0051170" ]
[]
[]
[]
[ "GO:0050658", "GO:0051170" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006405
6,405
RNA export from nucleus
biological_process
The directed movement of RNA from the nucleus to the cytoplasm.
[ "GOC:ma" ]
null
[ "RNA export from cell nucleus", "RNA export out of nucleus", "RNA transport from nucleus to cytoplasm", "RNA-nucleus export" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0050658", "GO:0051168" ]
[]
[]
[]
[ "GO:0050658", "GO:0051168" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006406
6,406
mRNA export from nucleus
biological_process
The directed movement of mRNA from the nucleus to the cytoplasm.
[ "GOC:ma" ]
null
[ "mRNA export from cell nucleus", "mRNA export out of nucleus", "mRNA transport from nucleus to cytoplasm", "mRNA-nucleus export" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-72202 \"Transport of Mature Transcript to Cytoplasm\"" ]
[ "GO:0006405", "GO:0051028" ]
[ "part_of GO:0010467" ]
[ "part_of" ]
[ "GO:0010467" ]
[ "GO:0006405", "GO:0010467", "GO:0051028" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0006407
6,407
obsolete rRNA export from nucleus
biological_process
OBSOLETE. The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins.
[ "GOC:ma", "GOC:mah" ]
The reason for obsoletion is that this term was added in error (rRNA is only exported as part of the pre ribosome).
[ "rRNA export from cell nucleus", "rRNA export out of nucleus", "rRNA transport from nucleus to cytoplasm", "rRNA-nucleus export" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0000054" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25263\" xsd:anyURI" ]
null
null
true
true
2
GO:0006408
6,408
snRNA export from nucleus
biological_process
The directed movement of snRNA from the nucleus to the cytoplasm.
[ "GOC:ma" ]
null
[ "snRNA export from cell nucleus", "snRNA export out of nucleus", "snRNA transport from nucleus to cytoplasm", "snRNA-nucleus export" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0006405", "GO:0051030" ]
[]
[]
[]
[ "GO:0006405", "GO:0051030" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0006409
6,409
tRNA export from nucleus
biological_process
The directed movement of tRNA from the nucleus to the cytoplasm.
[ "GOC:ma" ]
null
[ "tRNA export from cell nucleus", "tRNA export out of nucleus", "tRNA transport from nucleus to cytoplasm", "tRNA-nucleus export" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0006405", "GO:0051031" ]
[]
[]
[]
[ "GO:0006405", "GO:0051031" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006410
6,410
obsolete transcription, RNA-dependent
biological_process
OBSOLETE. The cellular synthesis of DNA on a template of RNA.
[ "GOC:jl" ]
This term was obsoleted because the name and the definition mean two completely different things: 1) "transcription, RNA-dependent", i.e. RNA-dependent production of an RNA transcript and 2) "reverse transcription", i.e. RNA-dependent DNA synthesis.
[ "transcription, RNA-dependent" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
3
GO:0006412
6,412
translation
biological_process
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA,...
[ "GOC:curators" ]
null
[ "protein translation" ]
[ "EXACT" ]
[ "GO:0006416", "GO:0006453", "GO:0043037" ]
[ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_metagenomics", "goslim_pir", "goslim_plant", "goslim_prokaryote", "goslim_prokaryote_ribbon" ]
[ "Reactome:R-HSA-72766 \"Translation\"", "Wikipedia:Translation_(genetics)" ]
[ "GO:0009059", "GO:0019538" ]
[ "has_part GO:0000048", "has_part GO:0006413", "has_part GO:0006414", "has_part GO:0006415", "part_of GO:0160307" ]
[ "has_part", "has_part", "has_part", "has_part", "part_of" ]
[ "GO:0000048", "GO:0006413", "GO:0006414", "GO:0006415", "GO:0160307" ]
[ "GO:0000048", "GO:0006413", "GO:0006414", "GO:0006415", "GO:0009059", "GO:0019538", "GO:0160307" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006413
6,413
translational initiation
biological_process
The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
[ "ISBN:019879276X" ]
null
[ "biopolymerisation", "biopolymerization", "protein synthesis initiation", "translation initiation" ]
[ "BROAD", "BROAD", "BROAD", "EXACT" ]
[ "GO:0006440", "GO:0006454" ]
[ "goslim_yeast" ]
[ "Reactome:R-HSA-72613 \"Eukaryotic Translation Initiation\"" ]
[ "GO:0008152" ]
[ "has_part GO:0001677", "part_of GO:0006412" ]
[ "has_part", "part_of" ]
[ "GO:0001677", "GO:0006412" ]
[ "GO:0001677", "GO:0006412", "GO:0008152" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0006414
6,414
translational elongation
biological_process
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
[ "GOC:ems" ]
null
[ "protein synthesis elongation", "translation elongation" ]
[ "BROAD", "EXACT" ]
[ "GO:0006442", "GO:0006455" ]
[ "goslim_yeast" ]
[ "Reactome:R-HSA-156842 \"Eukaryotic Translation Elongation\"" ]
[ "GO:0009059" ]
[ "part_of GO:0006412" ]
[ "part_of" ]
[ "GO:0006412" ]
[ "GO:0006412", "GO:0009059" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0006415
6,415
translational termination
biological_process
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
[ "GOC:hjd", "ISBN:019879276X" ]
null
[ "protein synthesis termination", "translation termination", "translational complex disassembly" ]
[ "BROAD", "EXACT", "EXACT" ]
[ "GO:0006443", "GO:0006456" ]
[]
[ "Reactome:R-HSA-72764 \"Eukaryotic Translation Termination\"" ]
[ "GO:0032984" ]
[ "part_of GO:0006412" ]
[ "part_of" ]
[ "GO:0006412" ]
[ "GO:0006412", "GO:0032984" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006417
6,417
regulation of translation
biological_process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
[ "GOC:isa_complete" ]
null
[ "regulation of protein anabolism", "regulation of protein biosynthesis", "regulation of protein formation", "regulation of protein synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[ "GO:0006445" ]
[ "goslim_yeast" ]
[]
[ "GO:0010608", "GO:0051246" ]
[ "regulates GO:0006412" ]
[ "regulates" ]
[ "GO:0006412" ]
[ "GO:0006412", "GO:0010608", "GO:0051246" ]
[ "GO:0065007", "regulates GO:0006412" ]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0006418
6,418
tRNA aminoacylation for protein translation
biological_process
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.
[ "GOC:ma" ]
null
[ "tRNA charging" ]
[ "NARROW" ]
[]
[ "goslim_yeast" ]
[ "MetaCyc:TRNA-CHARGING-PWY", "Reactome:R-HSA-379724 \"tRNA Aminoacylation\"" ]
[ "GO:0043039" ]
[ "part_of GO:0006412" ]
[ "part_of" ]
[ "GO:0006412" ]
[ "GO:0006412", "GO:0043039" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0006419
6,419
alanyl-tRNA aminoacylation
biological_process
The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0006421
6,421
asparaginyl-tRNA aminoacylation
biological_process
The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA.
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0006423
6,423
cysteinyl-tRNA aminoacylation
biological_process
The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterifica...
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006424
6,424
glutamyl-tRNA aminoacylation
biological_process
The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transester...
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006425
6,425
glutaminyl-tRNA aminoacylation
biological_process
The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transest...
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006426
6,426
glycyl-tRNA aminoacylation
biological_process
The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA.
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006427
6,427
histidyl-tRNA aminoacylation
biological_process
The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA.
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006428
6,428
isoleucyl-tRNA aminoacylation
biological_process
The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transeste...
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006429
6,429
leucyl-tRNA aminoacylation
biological_process
The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006431
6,431
methionyl-tRNA aminoacylation
biological_process
The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transeste...
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0006432
6,432
phenylalanyl-tRNA aminoacylation
biological_process
The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA ...
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0006433
6,433
prolyl-tRNA aminoacylation
biological_process
The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.
[ "GOC:mah", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006434
6,434
seryl-tRNA aminoacylation
biological_process
The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[ "has_part GO:0001717" ]
[ "has_part" ]
[ "GO:0001717" ]
[ "GO:0001717", "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0006436
6,436
tryptophanyl-tRNA aminoacylation
biological_process
The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via ...
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0006438
6,438
valyl-tRNA aminoacylation
biological_process
The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
[ "GOC:mcc", "ISBN:0716730510" ]
null
[]
[]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[ "GO:0006418" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0006439
6,439
obsolete aminoacyl-tRNA hydrolase reaction
biological_process
OBSOLETE. Hydrolysis of the peptidyl-tRNA by aminoacyl-tRNA hydrolase upon termination of translation. Analogous to usual peptidyl transfer during elongation, except that the acceptor is H2O instead of an aminoacyl-tRNA.
[ "ISBN:019879276X" ]
This term was made obsolete because it represents a molecular function.
[ "aminoacyl-tRNA hydrolase reaction" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0004045" ]
[]
[]
null
null
true
true
1
GO:0006441
6,441
obsolete binding to mRNA cap
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:hjd" ]
This term was made obsolete because it represents a function rather than a process.
[ "binding to mRNA cap" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0000339" ]
[]
null
null
true
true
2
GO:0006446
6,446
regulation of translational initiation
biological_process
Any process that modulates the frequency, rate or extent of translational initiation.
[ "GOC:curators" ]
null
[]
[]
[]
[]
[]
[ "GO:0006417" ]
[ "regulates GO:0006413" ]
[ "regulates" ]
[ "GO:0006413" ]
[ "GO:0006413", "GO:0006417" ]
[ "GO:0065007", "regulates GO:0006413" ]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0006447
6,447
regulation of translational initiation by iron
biological_process
Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron.
[ "GOC:jl" ]
null
[]
[]
[]
[]
[]
[ "GO:0006446" ]
[]
[]
[]
[ "GO:0006446" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0006449
6,449
regulation of translational termination
biological_process
Any process that modulates the frequency, rate or extent of translational termination.
[ "GOC:curators" ]
null
[]
[]
[]
[]
[]
[ "GO:0006417", "GO:0043244" ]
[ "regulates GO:0006415" ]
[ "regulates" ]
[ "GO:0006415" ]
[ "GO:0006415", "GO:0006417", "GO:0043244" ]
[ "GO:0065007", "regulates GO:0006415" ]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0006450
6,450
regulation of translational fidelity
biological_process
Any process that modulates the ability of the translational apparatus to interpret the genetic code.
[ "GOC:dph", "GOC:tb" ]
null
[ "regulation of translational accuracy" ]
[ "EXACT" ]
[ "GO:0000029" ]
[]
[]
[ "GO:0065008" ]
[]
[]
[]
[ "GO:0065008" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006451
6,451
translational readthrough
biological_process
The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons.
[ "GOC:jsg", "PMID:11179232" ]
null
[ "natural nonsense suppression" ]
[ "RELATED" ]
[]
[]
[]
[ "GO:0006414", "GO:0006417" ]
[]
[]
[]
[ "GO:0006414", "GO:0006417" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006452
6,452
translational frameshifting
biological_process
A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon.
[ "GOC:hjd", "ISBN:0195094425" ]
null
[]
[]
[]
[]
[ "Wikipedia:Translational_frameshift" ]
[ "GO:0006414" ]
[]
[]
[]
[ "GO:0006414" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0006457
6,457
protein folding
biological_process
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
[ "GOC:curators", "GOC:rb" ]
null
[ "alpha-tubulin folding", "beta-tubulin folding", "chaperone activity", "chaperonin ATPase activity", "chaperonin-mediated tubulin folding", "co-chaperone activity", "co-chaperonin activity", "glycoprotein-specific chaperone activity", "non-chaperonin molecular chaperone ATPase activity", "protein ...
[ "NARROW", "NARROW", "RELATED", "RELATED", "NARROW", "RELATED", "RELATED", "RELATED", "RELATED", "RELATED" ]
[ "GO:0007022", "GO:0007024", "GO:0007025" ]
[ "goslim_candida", "goslim_chembl", "goslim_drosophila", "goslim_euk_cellular_processes_ribbon", "goslim_generic", "goslim_metagenomics", "goslim_pir", "goslim_pombe", "goslim_prokaryote", "goslim_prokaryote_ribbon", "goslim_yeast" ]
[ "Reactome:R-HSA-389960 \"Formation of tubulin folding intermediates by CCT/TriC\"", "Reactome:R-HSA-390450 \"Folding of actin by CCT/TriC\"", "Reactome:R-HSA-390466 \"Chaperonin-mediated protein folding\"", "Reactome:R-HSA-532668 \"N-glycan trimming in the ER and Calnexin/Calreticulin cycle\"", "Wikipedia:P...
[ "GO:0009987" ]
[ "part_of GO:0051604" ]
[ "part_of" ]
[ "GO:0051604" ]
[ "GO:0009987", "GO:0051604" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/25673\" xsd:anyURI" ]
null
null
false
true
7
GO:0006458
6,458
'de novo' protein folding
biological_process
The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure.
[ "GOC:mb" ]
null
[ "nascent chain protein folding" ]
[ "EXACT" ]
[]
[]
[]
[ "GO:0006457" ]
[]
[]
[]
[ "GO:0006457" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006459
6,459
obsolete binding unfolded ER proteins
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:mah" ]
This term was made obsolete because it represents a function rather than a process.
[ "binding unfolded ER proteins" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0005783", "GO:0051082" ]
[]
null
null
true
true
4
GO:0006462
6,462
obsolete protein complex assembly, multichaperone pathway
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown.
[ "protein complex assembly, multichaperone pathway" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006457", "GO:0051131" ]
[]
null
null
true
true
6
GO:0006465
6,465
obsolete signal peptide processing
biological_process
OBSOLETE. The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell.
[ "GOC:mah", "PMID:31214988" ]
This term was obsoleted because it reprenset a molecular function, signal peptidase activity ; GO:0009003.
[ "leader peptide processing" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0051604" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30479\" xsd:anyURI" ]
null
null
true
true
1
GO:0006466
6,466
obsolete protein disulfide-isomerase reaction
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:ai" ]
This term was made obsolete because it presents a molecular function.
[ "protein disulfide-isomerase reaction", "protein disulphide-isomerase reaction" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0003756" ]
[]
[]
null
null
true
true
2
GO:0006468
6,468
protein phosphorylation
biological_process
The process of introducing a phosphate group on to a protein.
[ "GOC:hb" ]
null
[ "protein amino acid phosphorylation" ]
[ "EXACT" ]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0016310", "GO:0036211" ]
[]
[]
[]
[ "GO:0016310", "GO:0036211" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0006469
6,469
negative regulation of protein kinase activity
biological_process
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
[ "GOC:curators" ]
null
[ "down regulation of protein kinase activity", "down-regulation of protein kinase activity", "downregulation of protein kinase activity", "inhibition of protein kinase activity" ]
[ "EXACT", "EXACT", "EXACT", "NARROW" ]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0001933", "GO:0033673", "GO:0045859" ]
[ "negatively_regulates GO:0004672" ]
[ "negatively_regulates" ]
[ "GO:0004672" ]
[ "GO:0001933", "GO:0004672", "GO:0033673", "GO:0045859" ]
[ "GO:0065007", "negatively_regulates GO:0004672" ]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006471
6,471
obsolete protein ADP-ribosylation
biological_process
OBSOLETE. The transfer, from NAD, of ADP-ribose to protein amino acids.
[ "GOC:pr", "RESID:AA0040", "RESID:AA0168", "RESID:AA0169", "RESID:AA0231", "RESID:AA0237", "RESID:AA0295" ]
This term was obsoleted because it represents a molecular function.
[ "protein amino acid ADP-ribosylation" ]
[ "EXACT" ]
[]
[]
[ "RESID:AA0040", "RESID:AA0168", "RESID:AA0169", "RESID:AA0231", "RESID:AA0237", "RESID:AA0295" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:1990404" ]
[]
null
null
true
true
7
GO:0006473
6,473
protein acetylation
biological_process
The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.
[ "GOC:ai" ]
null
[ "protein amino acid acetylation" ]
[ "EXACT" ]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0043543" ]
[]
[]
[]
[ "GO:0043543" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
5
GO:0006474
6,474
N-terminal protein amino acid acetylation
biological_process
The acetylation of the N-terminal amino acid of proteins.
[ "GOC:ai" ]
null
[ "N(alpha)-terminal acetylation" ]
[ "NARROW" ]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0006473", "GO:0031365", "GO:0051604" ]
[]
[]
[]
[ "GO:0006473", "GO:0031365", "GO:0051604" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6
GO:0006475
6,475
internal protein amino acid acetylation
biological_process
The addition of an acetyl group to a non-terminal amino acid in a protein.
[ "GOC:mah" ]
null
[]
[]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0006473" ]
[]
[]
[]
[ "GO:0006473" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0006476
6,476
protein deacetylation
biological_process
The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.
[ "GOC:ai" ]
null
[ "protein amino acid deacetylation" ]
[ "EXACT" ]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0035601" ]
[]
[]
[]
[ "GO:0035601" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
4
GO:0006477
6,477
protein sulfation
biological_process
The addition of a sulfate group as an ester to a protein amino acid.
[ "GOC:curators" ]
null
[ "protein amino acid sulfation", "protein amino acid sulphation" ]
[ "EXACT", "EXACT" ]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0036211", "GO:0051923" ]
[]
[]
[]
[ "GO:0036211", "GO:0051923" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006479
6,479
protein methylation
biological_process
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
[ "GOC:ai" ]
null
[ "protein amino acid methylation" ]
[ "EXACT" ]
[]
[ "gocheck_obsoletion_candidate" ]
[ "Reactome:R-HSA-8876725 \"Protein methylation\"" ]
[ "GO:0008213", "GO:0043414" ]
[]
[]
[]
[ "GO:0008213", "GO:0043414" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
2
GO:0006480
6,480
N-terminal protein amino acid methylation
biological_process
The methylation of the N-terminal amino acid of a protein.
[ "GOC:ai" ]
null
[]
[]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0006479", "GO:0031365" ]
[]
[]
[]
[ "GO:0006479", "GO:0031365" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
1
GO:0006481
6,481
C-terminal protein methylation
biological_process
The methylation of the C-terminal amino acid of a protein.
[ "GOC:ai" ]
null
[ "C-terminal protein amino acid methylation" ]
[ "EXACT" ]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0006479", "GO:0018410" ]
[]
[]
[]
[ "GO:0006479", "GO:0018410" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
3
GO:0006482
6,482
protein demethylation
biological_process
The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
[ "GOC:mah" ]
null
[ "protein amino acid demethylation" ]
[ "EXACT" ]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0008214", "GO:0070988" ]
[]
[]
[]
[ "GO:0008214", "GO:0070988" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
9
GO:0006483
6,483
obsolete peptidyl-aspartic acid/asparagine hydroxylation
biological_process
OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine.
[ "GOC:ai" ]
This term was made obsolete because it is a redundant grouping term.
[ "aspartic acid/asparagine hydroxylation", "peptidyl-aspartic acid/asparagine hydroxylation" ]
[ "EXACT", "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0036140", "GO:0062101" ]
[]
null
null
true
true
9
GO:0006484
6,484
obsolete protein cysteine-thiol oxidation
biological_process
OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine.
[ "http://micro.magnet.fsu.edu/aminoacids/pages/cystine.html", "http://www.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html", "RESID:AA0025" ]
This term was made obsolete because it represents a single activity.
[ "protein cysteine-thiol oxidation" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0003756" ]
[]
null
null
true
true
6
GO:0006486
6,486
obsolete protein glycosylation
biological_process
OBSOLETE. A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
[ "GOC:curators", "GOC:pr" ]
The reason for obsoletion is that this term represents a molecular function.
[ "protein amino acid glycosylation" ]
[ "EXACT" ]
[ "GO:0065006" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0009101" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29770\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30371\" xsd:anyURI" ]
null
null
true
true
7
GO:0006487
6,487
protein N-linked glycosylation
biological_process
A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of an asparagine residue.
[ "PMID:35536965" ]
null
[ "N-glycan biosynthesis", "N-glycan metabolism", "protein amino acid N-linked glycosylation" ]
[ "RELATED", "RELATED", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-446203 \"Asparagine N-linked glycosylation\"", "Reactome:R-HSA-480985 \"Synthesis of dolichyl-phosphate-glucose\"" ]
[ "GO:0009101" ]
[]
[]
[]
[ "GO:0009101" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29770\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30595\" xsd:anyURI" ]
null
null
false
true
1
GO:0006488
6,488
dolichol-linked oligosaccharide biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P.
[ "GOC:jl", "ISBN:0471331309" ]
null
[ "dolichol-linked oligosaccharide anabolism", "dolichol-linked oligosaccharide biosynthesis", "dolichol-linked oligosaccharide formation", "dolichol-linked oligosaccharide synthesis", "N-linked glycan precursor biosynthesis", "N-linked glycan precursor biosynthetic process", "oligosaccharide-PP-dolichol ...
[ "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[ "Reactome:R-HSA-162699 \"Synthesis of dolichyl-phosphate mannose\"", "Reactome:R-HSA-446193 \"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein\"" ]
[ "GO:1901137" ]
[ "part_of GO:0006487" ]
[ "part_of" ]
[ "GO:0006487" ]
[ "GO:0006487", "GO:1901137" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28319\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28359\" xsd:anyURI" ]
null
null
false
true
3
GO:0006489
6,489
dolichyl diphosphate biosynthetic process
biological_process
The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative.
[ "ISBN:0198506732" ]
null
[ "dolichyl diphosphate anabolism", "dolichyl diphosphate biosynthesis", "dolichyl diphosphate formation", "dolichyl diphosphate synthesis" ]
[ "EXACT", "EXACT", "EXACT", "EXACT" ]
[]
[]
[]
[ "GO:0008654" ]
[ "part_of GO:0006488" ]
[ "part_of" ]
[ "GO:0006488" ]
[ "GO:0006488", "GO:0008654" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30376\" xsd:anyURI" ]
null
null
false
true
6
GO:0006490
6,490
obsolete oligosaccharide-lipid intermediate biosynthetic process
biological_process
OBSOLETE. The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation.
[ "GOC:dph", "GOC:hjd", "GOC:isa_complete", "GOC:pr", "GOC:rb" ]
This term was obsoleted because it is an unnecessary grouping term
[ "oligosaccharide-lipid intermediate assembly" ]
[ "NARROW" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006488" ]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28319\" xsd:anyURI", "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28373\" xsd:anyURI" ]
null
null
true
true
3
GO:0006491
6,491
N-glycan processing
biological_process
The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking.
[ "PMID:12736198", "PMID:35536965" ]
null
[ "glycoprotein trimming involved in glycoprotein maturation", "N-linked glycoprotein maturation" ]
[ "NARROW", "EXACT" ]
[ "GO:0006492" ]
[]
[]
[ "GO:0009101" ]
[ "part_of GO:0006487" ]
[ "part_of" ]
[ "GO:0006487" ]
[ "GO:0006487", "GO:0009101" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30024\" xsd:anyURI" ]
null
null
false
true
7
GO:0006493
6,493
protein O-linked glycosylation
biological_process
A glycoprotein biosynthetic process starting with the covalent linkage of carbohydrate or carbohydrate derivative unit via a glycosidic bond to the oxygen atom of a serine, threonine, hydroxylysine, hydroxyproline or tyrosine side chain in a protein, which can be further elongated with the sequential addition of sugar ...
[ "PMID:33775405" ]
null
[ "protein amino acid O-linked glycosylation" ]
[ "EXACT" ]
[]
[]
[ "Reactome:R-HSA-5173105 \"O-linked glycosylation\"", "RESID:AA0153", "RESID:AA0154", "RESID:AA0155", "RESID:AA0157", "RESID:AA0212" ]
[ "GO:0009101" ]
[]
[]
[]
[ "GO:0009101" ]
[]
[]
[]
[]
[]
[ "term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29770\" xsd:anyURI" ]
null
null
false
true
1
GO:0006494
6,494
obsolete protein amino acid terminal glycosylation
biological_process
OBSOLETE. A protein amino acid glycosylation process in which a sugar unit is added to a free alpha-amino or alpha-carboxyl terminal of a peptide.
[ "GOC:jsg" ]
This term was made obsolete because the term name is ambiguous.
[ "protein amino acid terminal glycosylation" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
6
GO:0006495
6,495
obsolete terminal O-glycosylation
biological_process
OBSOLETE. (Was not defined before being made obsolete).
[ "GOC:curators", "GOC:jsg" ]
This term was made obsolete because there is no evidence for the existence of this process.
[ "terminal O-glycosylation" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
null
null
true
true
5
GO:0006496
6,496
obsolete protein amino acid terminal N-glycosylation
biological_process
OBSOLETE. The glycosylation of a nitrogen atom of a free alpha amino terminal of a peptide.
[ "GOC:jsg" ]
This term was made obsolete because the term name is ambiguous.
[ "protein amino acid terminal N-glycosylation" ]
[ "EXACT" ]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[ "GO:0006487" ]
[]
null
null
true
true
8
GO:0006497
6,497
protein lipidation
biological_process
The covalent attachment of lipid groups to an amino acid in a protein.
[ "GOC:jl" ]
For non-covalent interactions with a lipid, consider instead the term 'lipid binding ; GO:0008289' and its children.
[ "lipid:protein modification", "protein amino acid lipidation" ]
[ "EXACT", "EXACT" ]
[ "GO:0042050" ]
[ "gocheck_obsoletion_candidate", "goslim_drosophila" ]
[ "RESID:AA0059", "RESID:AA0060", "RESID:AA0077", "RESID:AA0078", "RESID:AA0079", "RESID:AA0080", "RESID:AA0102", "RESID:AA0103", "RESID:AA0104", "RESID:AA0106", "RESID:AA0107", "RESID:AA0158", "RESID:AA0159", "RESID:AA0160", "RESID:AA0161", "RESID:AA0162", "RESID:AA0163", "RESID:AA0...
[ "GO:0036211" ]
[ "part_of GO:0042158" ]
[ "part_of" ]
[ "GO:0042158" ]
[ "GO:0036211", "GO:0042158" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
8
GO:0006498
6,498
N-terminal protein lipidation
biological_process
The covalent attachment of a lipid group to the amino terminus of a protein.
[ "GOC:jl" ]
null
[]
[]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0006497", "GO:0031365" ]
[]
[]
[]
[ "GO:0006497", "GO:0031365" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
7
GO:0006499
6,499
N-terminal protein myristoylation
biological_process
The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein.
[ "GOC:mah" ]
null
[]
[]
[]
[ "gocheck_obsoletion_candidate" ]
[]
[ "GO:0006498", "GO:0018377" ]
[]
[]
[]
[ "GO:0006498", "GO:0018377" ]
[]
[]
[]
[]
[]
[]
null
null
false
true
6