go_id string | go_numeric_id int64 | name string | namespace string | definition string | definition_xrefs list | comment string | synonyms list | synonym_scopes list | alt_ids list | subsets list | xrefs list | is_a_ids list | relationship_edges list | relationship_types list | relationship_target_ids list | parent_ids list | intersection_of list | union_of list | disjoint_from list | replaced_by list | consider list | property_values list | created_by string | creation_date string | is_obsolete bool | in_go_basic bool | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GO:0001565 | 1,565 | phorbol ester receptor activity | molecular_function | Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity. | [
"GOC:ai",
"GOC:signaling",
"PMID:10506570"
] | null | [] | [] | [] | [] | [] | [
"GO:0038023"
] | [] | [] | [] | [
"GO:0038023"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 1 |
GO:0001566 | 1,566 | non-kinase phorbol ester receptor activity | molecular_function | Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity. | [
"PMID:10506570"
] | null | [] | [] | [] | [] | [] | [
"GO:0001565"
] | [] | [] | [] | [
"GO:0001565"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 6 |
GO:0001567 | 1,567 | cholesterol 25-hydroxylase activity | molecular_function | Catalysis of the reaction: AH2 + cholesterol + O2 = 25-hydroxycholesterol + A + H2O. | [
"RHEA:21104"
] | null | [
"cholesterol 25-monooxygenase activity",
"cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity"
] | [
"RELATED",
"RELATED"
] | [] | [] | [
"EC:1.14.99.38",
"KEGG_REACTION:R07218",
"MetaCyc:1.14.99.38-RXN",
"RHEA:21104",
"RHEA:46132"
] | [
"GO:0008395",
"GO:0016705"
] | [] | [] | [] | [
"GO:0008395",
"GO:0016705"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:1.14.99.38",
"skos:exactMatch RHEA:21104",
"skos:narrowMatch RHEA:46132"
] | null | null | false | true | 7 |
GO:0001568 | 1,568 | blood vessel development | biological_process | The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood. | [
"GOC:hjd",
"UBERON:0001981"
] | null | [] | [] | [] | [] | [] | [
"GO:0048856"
] | [
"part_of GO:0001944"
] | [
"part_of"
] | [
"GO:0001944"
] | [
"GO:0001944",
"GO:0048856"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 7 |
GO:0001569 | 1,569 | branching involved in blood vessel morphogenesis | biological_process | The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. | [
"GOC:dph"
] | null | [
"patterning of blood vessels"
] | [
"BROAD"
] | [] | [] | [] | [
"GO:0048754"
] | [
"part_of GO:0001525"
] | [
"part_of"
] | [
"GO:0001525"
] | [
"GO:0001525",
"GO:0048754"
] | [
"GO:0048754",
"part_of GO:0048514"
] | [] | [] | [] | [] | [] | null | null | false | true | 6 |
GO:0001570 | 1,570 | vasculogenesis | biological_process | The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. | [
"PMID:8999798"
] | null | [
"vascular morphogenesis"
] | [
"EXACT"
] | [] | [] | [
"Wikipedia:Vasculogenesis"
] | [
"GO:0030154"
] | [
"part_of GO:0048514"
] | [
"part_of"
] | [
"GO:0048514"
] | [
"GO:0030154",
"GO:0048514"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 2 |
GO:0001571 | 1,571 | non-tyrosine kinase fibroblast growth factor receptor activity | molecular_function | Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity. | [
"GOC:signaling",
"PMID:11418238"
] | null | [
"non-tyrosine kinase FGF receptor activity",
"non-tyrosine kinase FGFR activity"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0004888"
] | [] | [] | [] | [
"GO:0004888"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 7 |
GO:0001572 | 1,572 | lactosylceramide biosynthetic process | biological_process | The chemical reactions and pathways resulting in the formation of lactosylceramides that begins with the synthesis of a disaccharide core 4-Gal-beta-1,4-Glc-ceramide. This core can be further elongated with the sequential addition of various carbohydrate units and is also the precursor for the synthesis of gangliosides... | [
"PMID:35536927"
] | null | [
"lacto-series glycosphingolipid biosynthesis",
"lactosylceramide anabolism",
"lactosylceramide biosynthesis",
"lactosylceramide formation",
"lactosylceramide synthesis"
] | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [
"MetaCyc:PWY-7839"
] | [
"GO:0006688",
"GO:0046513"
] | [] | [] | [] | [
"GO:0006688",
"GO:0046513"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30616\" xsd:anyURI"
] | null | null | false | true | 1 |
GO:0001573 | 1,573 | ganglioside metabolic process | biological_process | The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues. | [
"ISBN:0198506732"
] | null | [
"ganglioside metabolism"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0006672",
"GO:0006687"
] | [] | [] | [] | [
"GO:0006672",
"GO:0006687"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 6 |
GO:0001575 | 1,575 | globoside metabolic process | biological_process | The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes. | [
"ISBN:0198506732"
] | null | [
"globoside metabolism"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0006687"
] | [] | [] | [] | [
"GO:0006687"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
GO:0001576 | 1,576 | globoside biosynthetic process | biological_process | The chemical reactions and pathways resulting in the formation of gobliosides that begins with the synthesis of a tetrasaccharide core GalNAc-beta-1,3-Gal-alpha-1,4-Gal-beta-1,4-Glc-ceramide. This core can be further elongated with the sequential addition of various carbohydrate units. | [
"PMID:35536927"
] | null | [
"globo-series glycosphingolipid biosynthesis",
"globoside anabolism",
"globoside biosynthesis",
"globoside formation",
"globoside synthesis"
] | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [
"MetaCyc:PWY-7838"
] | [
"GO:0001575",
"GO:0006688"
] | [] | [] | [] | [
"GO:0001575",
"GO:0006688"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/29130\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30616\" xsd:anyURI"
] | null | null | false | true | 7 |
GO:0001577 | 1,577 | obsolete galectin | molecular_function | OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars. | [
"PMID:9786891"
] | This term was made obsolete because it refers to a class of gene products. | [
"galectin",
"S-type lectin"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0007157",
"GO:0016936"
] | [] | null | null | true | true | 3 |
GO:0001578 | 1,578 | microtubule bundle formation | biological_process | A process that results in a parallel arrangement of microtubules. | [
"GOC:dph"
] | null | [
"microtubule bundling"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0000226"
] | [] | [] | [] | [
"GO:0000226"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 2 |
GO:0001579 | 1,579 | medium-chain fatty acid transport | biological_process | The directed movement of a medium-chain fatty acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. | [
"GOC:ai"
] | While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). | [] | [] | [] | [] | [] | [
"GO:0015908"
] | [] | [] | [] | [
"GO:0015908"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26445\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0001580 | 1,580 | detection of chemical stimulus involved in sensory perception of bitter taste | biological_process | The series of events required for a bitter taste stimulus to be received and converted to a molecular signal. | [
"GOC:curators"
] | null | [
"bitter taste detection",
"perception of bitter taste, detection of chemical stimulus",
"perception of bitter taste, sensory transduction of chemical stimulus",
"sensory detection of bitter taste",
"sensory detection of chemical stimulus during perception of bitter taste",
"sensory transduction of bitter ... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0050912"
] | [
"part_of GO:0050913"
] | [
"part_of"
] | [
"GO:0050913"
] | [
"GO:0050912",
"GO:0050913"
] | [
"GO:0009593",
"part_of GO:0050913"
] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
GO:0001581 | 1,581 | detection of chemical stimulus involved in sensory perception of sour taste | biological_process | The series of events required for a sour taste stimulus to be received and converted to a molecular signal. | [
"GOC:curators"
] | null | [
"perception of sour taste, detection of chemical stimulus",
"perception of sour taste, sensory transduction of chemical stimulus",
"sensory detection of chemical stimulus during perception of sour taste",
"sensory detection of sour taste",
"sensory transduction of chemical stimulus during perception of sour... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0050912"
] | [
"part_of GO:0050915"
] | [
"part_of"
] | [
"GO:0050915"
] | [
"GO:0050912",
"GO:0050915"
] | [
"GO:0009593",
"part_of GO:0050915"
] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
GO:0001582 | 1,582 | detection of chemical stimulus involved in sensory perception of sweet taste | biological_process | The series of events required for a sweet taste stimulus to be received and converted to a molecular signal. | [
"GOC:curators"
] | null | [
"perception of sweet taste, detection of chemical stimulus",
"perception of sweet taste, sensory transduction of chemical stimulus",
"sensory detection of chemical stimulus during perception of sweet taste",
"sensory detection of sweet taste",
"sensory transduction of chemical stimulus during perception of ... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0050912"
] | [
"part_of GO:0050916"
] | [
"part_of"
] | [
"GO:0050916"
] | [
"GO:0050912",
"GO:0050916"
] | [
"GO:0009593",
"part_of GO:0050916"
] | [] | [] | [] | [] | [] | null | null | false | true | 1 |
GO:0001583 | 1,583 | obsolete detection of chemical stimulus involved in sensory perception of salty taste | biological_process | OBSOLETE. The series of events required for a salty taste stimulus to be received and converted to a molecular signal. | [
"GOC:curators"
] | This term was obsoleted because it is a pre-composed term that should be captured as a GO-CAM model. | [
"perception of salty taste, detection of chemical stimulus",
"perception of salty taste, sensory transduction of chemical stimulus",
"salty taste detection",
"sensory detection of chemical stimulus during perception of salty taste",
"sensory detection of salty taste",
"sensory transduction of chemical sti... | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0009593",
"GO:0050914"
] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31254\" xsd:anyURI"
] | null | null | true | true | 6 |
GO:0001584 | 1,584 | obsolete rhodopsin-like receptor activity | molecular_function | OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the rhodopsin receptor. | [
"GOC:dph",
"GOC:mah",
"GOC:tb",
"IUPHAR_GPCR:1505"
] | This term was made obsolete because it represents a gene product and is named based on protein features. | [
"Class A G protein coupled receptor",
"Class A G-protein coupled receptor",
"Class A GPCR",
"class A orphan receptor activity",
"rhodopsin-like receptor activity"
] | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [
"GO:0001620"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | null | null | true | true | 6 |
GO:0001586 | 1,586 | Gi/o-coupled serotonin receptor activity | molecular_function | Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels. | [
"GOC:mah",
"PMID:18571247"
] | null | [
"5-HT1 receptor activity",
"serotonin receptor activity, coupled via Gi/o"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0004993"
] | [] | [] | [] | [
"GO:0004993"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 2 |
GO:0001587 | 1,587 | Gq/11-coupled serotonin receptor activity | molecular_function | Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. | [
"GOC:bf",
"GOC:mah",
"PMID:18571247",
"PMID:18703043"
] | null | [
"5-HT2 receptor activity",
"serotonin receptor activity, coupled via Gq/11"
] | [
"BROAD",
"EXACT"
] | [] | [] | [] | [
"GO:0004993"
] | [] | [] | [] | [
"GO:0004993"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 1 |
GO:0001588 | 1,588 | dopamine neurotransmitter receptor activity, coupled via Gs | molecular_function | Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity. | [
"GOC:mah",
"ISBN:0953351033",
"IUPHAR_RECEPTOR:2252",
"IUPHAR_RECEPTOR:2260"
] | null | [
"dopamine D1 receptor activity",
"dopamine D5 receptor activity"
] | [
"NARROW",
"NARROW"
] | [
"GO:0001589",
"GO:0001590"
] | [] | [] | [
"GO:0004952"
] | [] | [] | [] | [
"GO:0004952"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
GO:0001591 | 1,591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go | molecular_function | Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity. | [
"GOC:mah",
"ISBN:0953351033",
"IUPHAR_RECEPTOR:2254",
"IUPHAR_RECEPTOR:2256",
"IUPHAR_RECEPTOR:2258"
] | null | [
"dopamine D2 receptor activity",
"dopamine D3 receptor activity",
"dopamine D4 receptor activity"
] | [
"NARROW",
"NARROW",
"NARROW"
] | [
"GO:0001592",
"GO:0001593",
"GO:0001670"
] | [] | [] | [
"GO:0004952"
] | [] | [] | [] | [
"GO:0004952"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 4 |
GO:0001594 | 1,594 | trace-amine receptor activity | molecular_function | Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals. | [
"GOC:mah",
"PMID:19325074"
] | null | [] | [] | [] | [] | [] | [
"GO:0008227"
] | [] | [] | [] | [
"GO:0008227"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
GO:0001596 | 1,596 | angiotensin type I receptor activity | molecular_function | An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms. | [
"GOC:mah",
"PMID:10977869"
] | null | [
"PLC-activating angiotensin receptor activity"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0001595"
] | [
"part_of GO:0086097"
] | [
"part_of"
] | [
"GO:0086097"
] | [
"GO:0001595",
"GO:0086097"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 3 |
GO:0001597 | 1,597 | obsolete apelin-like receptor | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:jl"
] | This term was made obsolete because the function it represents does not exist. | [
"apelin-like receptor",
"APJ-like receptor"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0031704"
] | [] | null | null | true | true | 9 |
GO:0001598 | 1,598 | obsolete chemokine receptor-like receptor activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:mah"
] | This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. | [
"chemokine receptor-like receptor activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | null | null | true | true | 4 |
GO:0001601 | 1,601 | peptide YY receptor activity | molecular_function | Combining with gut peptide YY to initiate a change in cell activity. | [
"PMID:9315606"
] | null | [] | [] | [] | [] | [] | [
"GO:0004983"
] | [] | [] | [] | [
"GO:0004983"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 6 |
GO:0001602 | 1,602 | pancreatic polypeptide receptor activity | molecular_function | Combining with pancreatic polypeptide PP to initiate a change in cell activity. | [
"PMID:9315606"
] | null | [] | [] | [] | [] | [] | [
"GO:0004983"
] | [] | [] | [] | [
"GO:0004983"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 7 |
GO:0001603 | 1,603 | obsolete vasopressin-like receptor activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:curators"
] | null | [
"vasopressin-like receptor activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | null | null | true | true | 2 |
GO:0001604 | 1,604 | urotensin II receptor activity | molecular_function | Combining with urotensin II to initiate a change in cell activity. | [
"GOC:mah",
"PMID:15102493"
] | null | [] | [] | [] | [] | [] | [
"GO:0008528"
] | [] | [] | [] | [
"GO:0008528"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 6 |
GO:0001605 | 1,605 | adrenomedullin receptor activity | molecular_function | Combining with adrenomedullin to initiate a change in cell activity. | [
"GOC:ai"
] | null | [
"G10D receptor"
] | [
"NARROW"
] | [] | [] | [] | [
"GO:0097642"
] | [] | [] | [] | [
"GO:0097642"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
GO:0001606 | 1,606 | obsolete GPR37/endothelin B-like receptor activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:mah"
] | This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. | [
"GPR37/endothelin B-like receptor activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | null | null | true | true | 3 |
GO:0001608 | 1,608 | G protein-coupled nucleotide receptor activity | molecular_function | Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. | [
"GOC:bf",
"GOC:dph",
"IUPHAR_GPCR:1294"
] | null | [
"G protein coupled nucleotide receptor activity",
"G-protein coupled nucleotide receptor activity",
"nucleotide receptor activity, G protein coupled",
"nucleotide receptor activity, G-protein coupled"
] | [
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0004930"
] | [] | [] | [] | [
"GO:0004930"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 3 |
GO:0001609 | 1,609 | G protein-coupled adenosine receptor activity | molecular_function | Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. | [
"GOC:bf",
"GOC:mah",
"PMID:9755289"
] | null | [
"A1 adenosine receptor activity, G protein coupled",
"A1 adenosine receptor activity, G-protein coupled",
"A2A adenosine receptor activity, G protein coupled",
"A2A adenosine receptor activity, G-protein coupled",
"A2B adenosine receptor activity, G protein coupled",
"A2B adenosine receptor activity, G-pr... | [
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"BROAD",
"EXACT",
"EXACT",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"EXACT",
"EXACT",
"NARROW",
"NARROW",
"NARROW",
"NARROW",
"EXACT"
] | [
"GO:0001610",
"GO:0001611",
"GO:0001612",
"GO:0001613",
"GO:0008501"
] | [] | [] | [
"GO:0004930"
] | [
"part_of GO:0001973"
] | [
"part_of"
] | [
"GO:0001973"
] | [
"GO:0001973",
"GO:0004930"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 3 |
GO:0001616 | 1,616 | growth hormone secretagogue receptor activity | molecular_function | Combining with ghrelin to initiate a change in cell activity. | [
"GOC:mah",
"PMID:17983853"
] | null | [
"ghrelin receptor activity"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0004930"
] | [] | [] | [] | [
"GO:0004930"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 9 |
GO:0001617 | 1,617 | obsolete growth hormone secretagogue-like receptor activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:mah"
] | This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. | [
"growth hormone secretagogue-like receptor activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | null | null | true | true | 8 |
GO:0001618 | 1,618 | virus receptor activity | molecular_function | Combining with a virus component and mediating entry of the virus into the cell. | [
"GOC:bf",
"GOC:dph",
"PMID:7621403",
"UniProtKB-KW:KW-1183"
] | null | [
"viral receptor activity"
] | [
"EXACT"
] | [] | [
"goslim_chembl",
"goslim_generic"
] | [
"Reactome:R-HSA-9922480 \"Dengue virion gets internalized\""
] | [
"GO:0140272"
] | [
"part_of GO:0046718"
] | [
"part_of"
] | [
"GO:0046718"
] | [
"GO:0046718",
"GO:0140272"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 4 |
GO:0001619 | 1,619 | obsolete lysosphingolipid and lysophosphatidic acid receptor activity | molecular_function | OBSOLETE. Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity. | [
"GOC:dph"
] | null | [
"lysosphingolipid and lysophosphatidic acid receptor activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0038036",
"GO:0070915"
] | [] | null | null | true | true | 2 |
GO:0001621 | 1,621 | G protein-coupled ADP receptor activity | molecular_function | Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. | [
"GOC:mah",
"GOC:signaling",
"PMID:11196645"
] | null | [
"ADP receptor activity",
"ADP-activated adenosine receptor activity",
"ADP-activated nucleotide receptor activity",
"K101 receptor",
"platelet ADP receptor activity"
] | [
"BROAD",
"RELATED",
"BROAD",
"NARROW",
"NARROW"
] | [
"GO:0045032"
] | [] | [] | [
"GO:0045028"
] | [
"has_part GO:0043531"
] | [
"has_part"
] | [
"GO:0043531"
] | [
"GO:0043531",
"GO:0045028"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 6 |
GO:0001626 | 1,626 | nociceptin receptor activity | molecular_function | Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. | [
"GOC:bf",
"GOC:mah",
"PMID:18670432"
] | null | [
"nociceptin/orphanin-FQ receptor activity",
"OFQ receptor activity",
"ORPH receptor",
"orphanin-FQ receptor activity",
"X-opioid receptor activity"
] | [
"EXACT",
"EXACT",
"EXACT",
"EXACT",
"RELATED"
] | [] | [] | [] | [
"GO:0004985",
"GO:0008528"
] | [] | [] | [] | [
"GO:0004985",
"GO:0008528"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/23197\" xsd:anyURI"
] | null | null | false | true | 4 |
GO:0001627 | 1,627 | obsolete leucine-rich G-protein receptor-like receptor activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:mah"
] | This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. | [
"leucine-rich G protein receptor-like receptor activity",
"leucine-rich G-protein receptor-like receptor activity",
"LGR-like receptor"
] | [
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | null | null | true | true | 7 |
GO:0001628 | 1,628 | obsolete gastropyloric receptor activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:mah"
] | This term was made obsolete because the gastropyloric receptor is a type of neuron. | [
"gastropyloric receptor activity",
"GPR receptor"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | null | null | true | true | 8 |
GO:0001629 | 1,629 | obsolete G-protein receptor 45-like receptor activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:mah"
] | This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. | [
"G protein receptor 45-like receptor activity",
"G-protein receptor 45-like receptor activity",
"GPR45-like receptor"
] | [
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | null | null | true | true | 9 |
GO:0001631 | 1,631 | cysteinyl leukotriene receptor activity | molecular_function | Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine. | [
"GOC:ai",
"ISBN:0198506732"
] | null | [
"CysLT receptor"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0004974"
] | [] | [] | [] | [
"GO:0004974"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 5 |
GO:0001632 | 1,632 | leukotriene B4 receptor activity | molecular_function | Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate. | [
"GOC:ai",
"ISBN:0198506732"
] | null | [
"BLT receptor"
] | [
"NARROW"
] | [] | [] | [] | [
"GO:0004974"
] | [] | [] | [] | [
"GO:0004974"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 5 |
GO:0001634 | 1,634 | pituitary adenylate cyclase-activating polypeptide receptor activity | molecular_function | A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide. | [
"GOC:dph",
"GOC:tb"
] | null | [
"PACAP receptor",
"pituitary adenylate cyclase activating polypeptide receptor",
"pituitary adenylate cyclase activating protein receptor activity",
"pituitary adenylate cyclase-activating peptide receptor activity",
"pituitary adenylyl cyclase activating protein receptor activity"
] | [
"EXACT",
"EXACT",
"EXACT",
"RELATED",
"EXACT"
] | [
"GO:0016522"
] | [] | [] | [
"GO:0004930"
] | [] | [] | [] | [
"GO:0004930"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 3 |
GO:0001635 | 1,635 | calcitonin gene-related peptide receptor activity | molecular_function | Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity. | [
"GOC:mah",
"PMID:12037140"
] | null | [
"calcitonin gene-related polypeptide receptor activity",
"CGRP receptor"
] | [
"EXACT",
"EXACT"
] | [] | [] | [
"Wikipedia:CALCRL"
] | [
"GO:0097642"
] | [] | [] | [] | [
"GO:0097642"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
GO:0001636 | 1,636 | obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity | molecular_function | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:mah"
] | This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. | [
"corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | null | null | true | true | 8 |
GO:0001637 | 1,637 | G protein-coupled chemoattractant receptor activity | molecular_function | Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. | [
"GOC:bf",
"GOC:mah"
] | null | [
"G protein chemoattractant receptor activity",
"G-protein chemoattractant receptor activity",
"G-protein coupled chemoattractant receptor activity"
] | [
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0004930"
] | [] | [] | [] | [
"GO:0004930"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 3 |
GO:0001639 | 1,639 | PLC activating G protein-coupled glutamate receptor activity | molecular_function | A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system. | [
"PMID:9016303"
] | null | [
"Group I metabotropic glutamate receptor",
"group I metabotropic glutamate receptor activity",
"phospholipase C activating metabotropic glutamate receptor activity",
"PLC activating G-protein coupled glutamate receptor activity",
"PLC activating metabotropic glutamate receptor activity"
] | [
"RELATED",
"RELATED",
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0098988"
] | [
"part_of GO:0007206"
] | [
"part_of"
] | [
"GO:0007206"
] | [
"GO:0007206",
"GO:0098988"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 2 |
GO:0001640 | 1,640 | adenylate cyclase inhibiting G protein-coupled glutamate receptor activity | molecular_function | Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity. | [
"GOC:bf",
"GOC:dph"
] | null | [
"adenylate cyclase inhibiting metabotropic glutamate receptor activity",
"adenylyl cyclase inhibiting metabotropic glutamate receptor activity"
] | [
"RELATED",
"EXACT"
] | [] | [] | [] | [
"GO:0098988"
] | [
"part_of GO:0007196"
] | [
"part_of"
] | [
"GO:0007196"
] | [
"GO:0007196",
"GO:0098988"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 2 |
GO:0001641 | 1,641 | group II metabotropic glutamate receptor activity | molecular_function | A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity. | [
"GOC:dph"
] | null | [] | [] | [] | [] | [] | [
"GO:0001640"
] | [] | [] | [] | [
"GO:0001640"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 3 |
GO:0001642 | 1,642 | group III metabotropic glutamate receptor activity | molecular_function | A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity. | [
"PMID:9016303"
] | null | [] | [] | [] | [] | [] | [
"GO:0001640"
] | [] | [] | [] | [
"GO:0001640"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 5 |
GO:0001646 | 1,646 | cAMP receptor activity | molecular_function | Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. | [
"GOC:pg"
] | null | [
"3',5' cAMP receptor activity",
"3',5'-cAMP receptor activity",
"adenosine 3',5'-cyclophosphate receptor activity",
"class E G protein coupled receptor",
"class E G-protein coupled receptor",
"class E GPCR",
"cyclic AMP receptor activity"
] | [
"EXACT",
"EXACT",
"EXACT",
"BROAD",
"BROAD",
"BROAD",
"EXACT"
] | [
"GO:0001644"
] | [] | [] | [
"GO:0045028"
] | [
"has_part GO:0030552"
] | [
"has_part"
] | [
"GO:0030552"
] | [
"GO:0030552",
"GO:0045028"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 9 |
GO:0001647 | 1,647 | G protein-coupled cytokinin receptor activity | molecular_function | Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. | [
"GOC:bf",
"GOC:dph"
] | null | [
"cytokinin receptor activity, G-protein coupled",
"G protein coupled cytokinin receptor activity",
"G-protein coupled cytokinin receptor activity"
] | [
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0004930",
"GO:0009884"
] | [] | [] | [] | [
"GO:0004930",
"GO:0009884"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 9 |
GO:0001649 | 1,649 | osteoblast differentiation | biological_process | The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. | [
"CL:0000062",
"GO_REF:0000034",
"GOC:jid"
] | null | [
"osteoblast cell differentiation"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0030154"
] | [
"part_of GO:0001503"
] | [
"part_of"
] | [
"GO:0001503"
] | [
"GO:0001503",
"GO:0030154"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 2 |
GO:0001650 | 1,650 | fibrillar center | cellular_component | A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures. | [
"PMID:10754561"
] | null | [
"fibrillar centre"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0110165"
] | [
"part_of GO:0005730"
] | [
"part_of"
] | [
"GO:0005730"
] | [
"GO:0005730",
"GO:0110165"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 3 |
GO:0001651 | 1,651 | dense fibrillar component | cellular_component | A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins. | [
"PMID:10754561"
] | null | [
"pars fibrosa"
] | [
"BROAD"
] | [] | [] | [
"NIF_Subcellular:sao1841764412"
] | [
"GO:0110165"
] | [
"part_of GO:0005730"
] | [
"part_of"
] | [
"GO:0005730"
] | [
"GO:0005730",
"GO:0110165"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 1 |
GO:0001652 | 1,652 | granular component | cellular_component | A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm. | [
"PMID:10754561"
] | null | [
"pars granulosa"
] | [
"BROAD"
] | [] | [] | [
"NIF_Subcellular:sao1217793903"
] | [
"GO:0110165"
] | [
"part_of GO:0005730"
] | [
"part_of"
] | [
"GO:0005730"
] | [
"GO:0005730",
"GO:0110165"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 9 |
GO:0001653 | 1,653 | peptide receptor activity | molecular_function | Combining with an extracellular or intracellular peptide to initiate a change in cell activity. | [
"GOC:jl"
] | null | [
"endogenous peptide receptor activity",
"exogenous peptide receptor activity"
] | [
"NARROW",
"NARROW"
] | [] | [] | [] | [
"GO:0038023"
] | [
"has_part GO:0042277"
] | [
"has_part"
] | [
"GO:0042277"
] | [
"GO:0038023",
"GO:0042277"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 2 |
GO:0001654 | 1,654 | eye development | biological_process | The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight. | [
"GOC:jid",
"GOC:jl"
] | null | [] | [] | [
"GO:0042460"
] | [] | [
"Wikipedia:Eye_development"
] | [
"GO:0007423"
] | [
"part_of GO:0150063"
] | [
"part_of"
] | [
"GO:0150063"
] | [
"GO:0007423",
"GO:0150063"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 2 |
GO:0001655 | 1,655 | urogenital system development | biological_process | The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. | [
"GOC:curators"
] | null | [] | [] | [] | [] | [] | [
"GO:0048731"
] | [
"has_part GO:0072001"
] | [
"has_part"
] | [
"GO:0072001"
] | [
"GO:0048731",
"GO:0072001"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/22178\" xsd:anyURI"
] | null | null | false | true | 9 |
GO:0001656 | 1,656 | metanephros development | biological_process | The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocr... | [
"GOC:bf",
"ISBN:0192800752"
] | null | [] | [] | [] | [] | [] | [
"GO:0001822"
] | [] | [] | [] | [
"GO:0001822"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 4 |
GO:0001657 | 1,657 | ureteric bud development | biological_process | The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure. | [
"GOC:curators"
] | null | [] | [] | [] | [] | [] | [
"GO:0072164"
] | [] | [] | [] | [
"GO:0072164"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 7 |
GO:0001659 | 1,659 | temperature homeostasis | biological_process | A homeostatic process in which an organism modulates its internal body temperature. | [
"GOC:jl"
] | null | [
"thermoregulation"
] | [
"EXACT"
] | [] | [] | [
"Wikipedia:Thermoregulation"
] | [
"GO:0048871"
] | [] | [] | [] | [
"GO:0048871"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 2 |
GO:0001660 | 1,660 | fever generation | biological_process | The heat generation process that results in a rise in body temperature above the normal, often as a response to infection. | [
"GOC:dph",
"GOC:jl"
] | null | [
"pyrexia"
] | [
"BROAD"
] | [] | [] | [
"Wikipedia:Fever"
] | [
"GO:0006953",
"GO:0031649"
] | [] | [] | [] | [
"GO:0006953",
"GO:0031649"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 4 |
GO:0001661 | 1,661 | conditioned taste aversion | biological_process | A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus. | [
"GOC:dph",
"PMID:9920659"
] | null | [] | [] | [] | [] | [
"Wikipedia:Conditioned_taste_aversion",
"Wikipedia:Taste_aversion"
] | [
"GO:0007631",
"GO:0008306"
] | [] | [] | [] | [
"GO:0007631",
"GO:0008306"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 1 |
GO:0001662 | 1,662 | behavioral fear response | biological_process | An acute behavioral change resulting from a perceived external threat. | [
"GOC:dph",
"PMID:9920659"
] | null | [
"behavioural fear response"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0002209",
"GO:0042596"
] | [] | [] | [] | [
"GO:0002209",
"GO:0042596"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/31407\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0001664 | 1,664 | G protein-coupled receptor binding | molecular_function | Binding to a G protein-coupled receptor. | [
"GOC:ceb",
"GOC:dph"
] | null | [
"G protein coupled receptor binding",
"G protein coupled receptor ligand",
"G-protein coupled receptor binding",
"G-protein-coupled receptor ligand"
] | [
"EXACT",
"NARROW",
"EXACT",
"NARROW"
] | [] | [] | [
"Reactome:R-HSA-500717 \"Activation of GRIK3 homomer\""
] | [
"GO:0005102"
] | [] | [] | [] | [
"GO:0005102"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 5 |
GO:0001665 | 1,665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity | molecular_function | Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. | [
"EC:2.4.3.3"
] | null | [
"GalNAc alpha-2,6-sialyltransferase I activity"
] | [
"RELATED"
] | [] | [] | [
"EC:2.4.3.3",
"MetaCyc:2.4.99.3-RXN",
"Reactome:R-HSA-4084980 \"ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)\"",
"Reactome:R-HSA-9603991 \"ST6GALNAC6 transfers Neu5Ac to Type 1 MSGG to form Type 1 DSGG\"",
"Reactome:R-HSA-9846305 \"ST6GALNAC5,6 transfer Neu5Ac to GM1b\"",
"RHEA:11136",... | [
"GO:0008373"
] | [] | [] | [] | [
"GO:0008373"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:2.4.3.3",
"skos:exactMatch RHEA:11136",
"skos:narrowMatch RHEA:81651",
"skos:narrowMatch RHEA:81655",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 5 |
GO:0001666 | 1,666 | response to hypoxia | biological_process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabo... | [
"GOC:hjd"
] | Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. | [
"response to hypoxic stress",
"response to intermittent hypoxia",
"response to lowered oxygen tension",
"response to sustained hypoxia"
] | [
"EXACT",
"NARROW",
"EXACT",
"NARROW"
] | [] | [] | [] | [
"GO:0006950",
"GO:0036293"
] | [] | [] | [] | [
"GO:0006950",
"GO:0036293"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 7 |
GO:0001667 | 1,667 | ameboidal-type cell migration | biological_process | Cell migration that is accomplished by extension and retraction of a pseudopodium. | [
"GOC:dph"
] | Note that this term refers to a mode of migration rather than to any particular cell type. | [
"ameboid cell migration",
"amoeboid cell migration",
"amoeboidal cell migration"
] | [
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0016477"
] | [] | [] | [] | [
"GO:0016477"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 1 |
GO:0001669 | 1,669 | acrosomal vesicle | cellular_component | A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. | [
"ISBN:0124325653",
"ISBN:0198506732"
] | null | [
"acrosomal granule",
"acrosome"
] | [
"EXACT",
"EXACT"
] | [] | [] | [
"Wikipedia:Acrosome"
] | [
"GO:0030141"
] | [] | [] | [] | [
"GO:0030141"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 1 |
GO:0001671 | 1,671 | ATPase activator activity | molecular_function | Binds to and increases the activity of an ATP hydrolysis activity. | [
"GOC:ajp"
] | null | [
"ATPase stimulator activity"
] | [
"EXACT"
] | [] | [] | [
"Reactome:R-HSA-5251955 \"HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm\"",
"Reactome:R-HSA-5251959 \"HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol\""
] | [
"GO:0140677"
] | [
"positively_regulates GO:0140657"
] | [
"positively_regulates"
] | [
"GO:0140657"
] | [
"GO:0140657",
"GO:0140677"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/20955\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0001673 | 1,673 | male germ cell nucleus | cellular_component | The nucleus of a male germ cell, a reproductive cell in males. | [
"CL:0000015",
"GOC:hjd",
"GOC:mtg_sensu"
] | null | [
"male germ-cell nucleus"
] | [
"EXACT"
] | [
"GO:0043081"
] | [] | [] | [
"GO:0043073"
] | [] | [] | [] | [
"GO:0043073"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 9 |
GO:0001674 | 1,674 | female germ cell nucleus | cellular_component | The nucleus of the female germ cell, a reproductive cell in females. | [
"CL:0000021",
"GOC:hjd"
] | null | [
"female germ-cell nucleus"
] | [
"EXACT"
] | [
"GO:0043080"
] | [] | [] | [
"GO:0043073"
] | [] | [] | [] | [
"GO:0043073"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 7 |
GO:0001675 | 1,675 | acrosome assembly | biological_process | The formation of the acrosome from the spermatid Golgi. | [
"GOC:dph",
"GOC:hjd",
"GOC:tb"
] | null | [
"acrosome formation"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0003006",
"GO:0010927",
"GO:0022412",
"GO:0033363",
"GO:0070925"
] | [
"part_of GO:0007286"
] | [
"part_of"
] | [
"GO:0007286"
] | [
"GO:0003006",
"GO:0007286",
"GO:0010927",
"GO:0022412",
"GO:0033363",
"GO:0070925"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 1 |
GO:0001676 | 1,676 | long-chain fatty acid metabolic process | biological_process | The chemical reactions and pathways involving a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. | [
"GOC:ajp"
] | While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283). | [
"long-chain fatty acid metabolism"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0006631"
] | [] | [] | [] | [
"GO:0006631"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26445\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0001677 | 1,677 | formation of translation initiation ternary complex | biological_process | Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). | [
"GOC:hjd"
] | null | [
"translation initiation ternary complex assembly"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0022618"
] | [
"part_of GO:0006413"
] | [
"part_of"
] | [
"GO:0006413"
] | [
"GO:0006413",
"GO:0022618"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 7 |
GO:0001678 | 1,678 | intracellular glucose homeostasis | biological_process | A homeostatic process involved in the maintenance of a steady state level of glucose within a cell. | [
"GOC:curators",
"GOC:dph",
"GOC:tb"
] | null | [
"cell glucose homeostasis",
"cellular glucose homeostasis"
] | [
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0042593",
"GO:0055082"
] | [] | [] | [] | [
"GO:0042593",
"GO:0055082"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 9 |
GO:0001680 | 1,680 | tRNA 3'-terminal CCA addition | biological_process | Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition. | [
"GOC:curators",
"PMID:2247609"
] | null | [] | [] | [] | [] | [] | [
"GO:0042780"
] | [
"has_part GO:0004810",
"has_part GO:0052927",
"has_part GO:0052929"
] | [
"has_part",
"has_part",
"has_part"
] | [
"GO:0004810",
"GO:0052927",
"GO:0052929"
] | [
"GO:0004810",
"GO:0042780",
"GO:0052927",
"GO:0052929"
] | [] | [] | [] | [] | [] | [
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/19854\" xsd:anyURI"
] | null | null | false | true | 3 |
GO:0001681 | 1,681 | sialate O-acetylesterase activity | molecular_function | Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate. | [
"EC:3.1.1.53",
"PMID:1991039"
] | null | [
"N-acetylneuraminate acetyltransferase activity"
] | [
"RELATED"
] | [] | [] | [
"EC:3.1.1.53"
] | [
"GO:0008126"
] | [] | [] | [] | [
"GO:0008126"
] | [] | [] | [] | [] | [] | [
"skos:exactMatch EC:3.1.1.53",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/26015\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/28526\" xsd:anyURI",
"term_tracker_item \"https://github.com/geneontology/go-ontology/issues/30193\" xsd:anyURI"
] | null | null | false | true | 2 |
GO:0001682 | 1,682 | tRNA 5'-leader removal | biological_process | Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. | [
"PMID:11592395"
] | null | [
"tRNA 5' leader removal"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0099116"
] | [] | [] | [] | [
"GO:0099116"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 6 |
GO:0001683 | 1,683 | obsolete axonemal dynein heavy chain | cellular_component | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:jl"
] | This term was made obsolete because it represents a single gene product and not a complex. | [
"axonemal dynein heavy chain"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0005858"
] | [] | [] | null | null | true | true | 4 |
GO:0001684 | 1,684 | obsolete axonemal dynein intermediate chain | cellular_component | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:jl"
] | This term was made obsolete because it represents a single gene product and not a complex. | [
"axonemal dynein intermediate chain"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0005858"
] | [] | [] | null | null | true | true | 3 |
GO:0001685 | 1,685 | obsolete axonemal dynein intermediate light chain | cellular_component | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:jl"
] | This term was made obsolete because it represents a single gene product and not a complex. | [
"axonemal dynein intermediate light chain"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0005858"
] | [] | [] | null | null | true | true | 8 |
GO:0001686 | 1,686 | obsolete axonemal dynein light chain | cellular_component | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:jl"
] | This term was made obsolete because it represents a single gene product and not a complex. | [
"axonemal dynein light chain"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0005858"
] | [] | [] | null | null | true | true | 8 |
GO:0001687 | 1,687 | obsolete cytoplasmic dynein heavy chain | cellular_component | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:jl"
] | This term was made obsolete because it represents a single gene product and not a complex. | [
"cytoplasmic dynein heavy chain"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0005868"
] | [] | [] | null | null | true | true | 9 |
GO:0001688 | 1,688 | obsolete cytoplasmic dynein intermediate chain | cellular_component | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:jl"
] | This term was made obsolete because it represents a single gene product and not a complex. | [
"cytoplasmic dynein intermediate chain"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0005868"
] | [] | [] | null | null | true | true | 9 |
GO:0001689 | 1,689 | obsolete cytoplasmic dynein intermediate light chain | cellular_component | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:jl"
] | This term was made obsolete because it represents a single gene product and not a complex. | [
"cytoplasmic dynein intermediate light chain"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0005868"
] | [] | [] | null | null | true | true | 8 |
GO:0001690 | 1,690 | obsolete cytoplasmic dynein light chain | cellular_component | OBSOLETE. (Was not defined before being made obsolete). | [
"GOC:jl"
] | This term was made obsolete because it represents a single gene product and not a complex. | [
"cytoplasmic dynein light chain"
] | [
"EXACT"
] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [] | [
"GO:0005868"
] | [] | [] | null | null | true | true | 4 |
GO:0001691 | 1,691 | pseudophosphatase activity | molecular_function | Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical a... | [
"GOC:ajp"
] | null | [] | [] | [] | [] | [] | [
"GO:0019212"
] | [] | [] | [] | [
"GO:0019212"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 9 |
GO:0001692 | 1,692 | histamine metabolic process | biological_process | The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. | [
"GOC:jl",
"ISBN:0395825172"
] | null | [
"histamine metabolism"
] | [
"EXACT"
] | [] | [] | [] | [
"GO:0006576",
"GO:0052803"
] | [] | [] | [] | [
"GO:0006576",
"GO:0052803"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 4 |
GO:0001694 | 1,694 | histamine biosynthetic process | biological_process | The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. | [
"GOC:jl",
"ISBN:0395825172"
] | null | [
"histamine anabolism",
"histamine biosynthesis",
"histamine formation",
"histamine synthesis"
] | [
"EXACT",
"EXACT",
"EXACT",
"EXACT"
] | [
"GO:0001693"
] | [] | [] | [
"GO:0001692",
"GO:0042401"
] | [] | [] | [] | [
"GO:0001692",
"GO:0042401"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 9 |
GO:0001695 | 1,695 | histamine catabolic process | biological_process | The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. | [
"GOC:jl",
"ISBN:0395825172"
] | null | [
"histamine breakdown",
"histamine catabolism",
"histamine degradation"
] | [
"EXACT",
"EXACT",
"EXACT"
] | [] | [] | [] | [
"GO:0001692",
"GO:0042402",
"GO:0052805"
] | [] | [] | [] | [
"GO:0001692",
"GO:0042402",
"GO:0052805"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 4 |
GO:0001696 | 1,696 | gastric acid secretion | biological_process | The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. | [
"GOC:hjd"
] | null | [
"hydrochloric acid secretion"
] | [
"NARROW"
] | [] | [] | [] | [
"GO:0022600",
"GO:0046717"
] | [] | [] | [] | [
"GO:0022600",
"GO:0046717"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
GO:0001697 | 1,697 | histamine-induced gastric acid secretion | biological_process | The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP. | [
"GOC:hjd"
] | null | [] | [] | [] | [] | [] | [
"GO:0001696"
] | [] | [] | [] | [
"GO:0001696"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 3 |
GO:0001698 | 1,698 | gastrin-induced gastric acid secretion | biological_process | The regulated release of gastric acid induced by the interaction of gastrin with its receptor. | [
"GOC:hjd"
] | null | [] | [] | [] | [] | [] | [
"GO:0001696"
] | [
"has_part GO:0015054"
] | [
"has_part"
] | [
"GO:0015054"
] | [
"GO:0001696",
"GO:0015054"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
GO:0001699 | 1,699 | acetylcholine-induced gastric acid secretion | biological_process | The regulated release of gastric acid by parietal cells in response to acetylcholine. | [
"GOC:hjd"
] | null | [] | [] | [] | [] | [] | [
"GO:0001696"
] | [
"has_part GO:0015464",
"part_of GO:1905145"
] | [
"has_part",
"part_of"
] | [
"GO:0015464",
"GO:1905145"
] | [
"GO:0001696",
"GO:0015464",
"GO:1905145"
] | [] | [] | [] | [] | [] | [] | null | null | false | true | 8 |
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