prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CN([C@@H]2CCCCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-]
|
CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-]
|
CC1(C)CN([C@@H]2CCCCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCCN&C1=O",
"old_substring": "[C@@H]14CCN5C1=O"
}
|
Can you make molecule CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CN([C@@H]2CN(c3ccccc3Cl)CCS2)CC[S@+]1[O-]
|
CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-]
|
CC1(C)CN([C@@H]2CN(c3ccccc3Cl)CCS2)CC[S@+]1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CN&CCS1",
"old_substring": "[C@@H]14CCN5C1=O"
}
|
Can you make molecule CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CN([C@@H]2CCN(Cc3ccccc3Cl)C2)CC[S@+]1[O-]
|
CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-]
|
CC1(C)CN([C@@H]2CCN(Cc3ccccc3Cl)C2)CC[S@+]1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCN(C&)C1",
"old_substring": "[C@@H]14CCN5C1=O"
}
|
Can you make molecule CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CN([C@H]2CCCCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-]
|
CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-]
|
CC1(C)CN([C@H]2CCCCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCCN&C1=O",
"old_substring": "[C@@H]14CCN5C1=O"
}
|
Can you make molecule CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CN([C@@H]2CCCN(c3ccccc3Cl)CC2)CC[S@+]1[O-]
|
CC1(C)CN([C@@H]2CCN(c3ccccc3Cl)C2=O)CC[S@+]1[O-]
|
CC1(C)CN([C@@H]2CCCN(c3ccccc3Cl)CC2)CC[S@+]1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCN&CC1",
"old_substring": "[C@@H]14CCN5C1=O"
}
|
Can you make molecule C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)Cc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)C[C@H](Cc1ccccc1)NSC(=O)Cc1cccc2ccccc12
|
C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)Cc1cccc2ccccc12
|
C[NH+](C)C[C@H](Cc1ccccc1)NSC(=O)Cc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C3(=O)C7"
}
|
Can you make molecule C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)Cc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)CCCC(=O)c1cccc2ccccc12
|
C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)Cc1cccc2ccccc12
|
C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)CCCC(=O)c1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C3(=O)C7"
}
|
Can you make molecule C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)Cc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)CC(C)(C)c1cccc2ccccc12
|
C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)Cc1cccc2ccccc12
|
C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)CC(C)(C)c1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C3(=O)C7"
}
|
Can you make molecule C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)Cc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)C[C@H](Cc1ccccc1)NC[S@+]([O-])CCCc1cccc2ccccc12
|
C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)Cc1cccc2ccccc12
|
C[NH+](C)C[C@H](Cc1ccccc1)NC[S@+]([O-])CCCc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C3(=O)C7"
}
|
Can you make molecule C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)Cc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)CCC(C)(C)c1cccc2ccccc12
|
C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)Cc1cccc2ccccc12
|
C[NH+](C)C[C@H](Cc1ccccc1)NC(=O)CCC(C)(C)c1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C3(=O)C7"
}
|
Can you make molecule CC[C@H](C)C[C@H](C)NC(=O)[C@@H]1CCC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C[C@H](C)NSC(=O)C[C@@H]1CCC[NH2+][C@@H]1C
|
CC[C@H](C)C[C@H](C)NC(=O)[C@@H]1CCC[NH2+][C@@H]1C
|
CC[C@H](C)C[C@H](C)NSC(=O)C[C@@H]1CCC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule CC[C@H](C)C[C@H](C)NC(=O)[C@@H]1CCC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C[C@H](C)NCC(=C=O)C[C@@H]1CCC[NH2+][C@@H]1C
|
CC[C@H](C)C[C@H](C)NC(=O)[C@@H]1CCC[NH2+][C@@H]1C
|
CC[C@H](C)C[C@H](C)NCC(=C=O)C[C@@H]1CCC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule CC[C@H](C)C[C@H](C)NC(=O)[C@@H]1CCC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C[C@H](C)NC(=O)CCCC(=O)[C@@H]1CCC[NH2+][C@@H]1C
|
CC[C@H](C)C[C@H](C)NC(=O)[C@@H]1CCC[NH2+][C@@H]1C
|
CC[C@H](C)C[C@H](C)NC(=O)CCCC(=O)[C@@H]1CCC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C24=O"
}
|
Can you make molecule CC[C@H](C)C[C@H](C)NC(=O)[C@@H]1CCC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C[C@H](C)NC(=O)CC(C)(C)[C@@H]1CCC[NH2+][C@@H]1C
|
CC[C@H](C)C[C@H](C)NC(=O)[C@@H]1CCC[NH2+][C@@H]1C
|
CC[C@H](C)C[C@H](C)NC(=O)CC(C)(C)[C@@H]1CCC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule CC[C@H](C)C[C@H](C)NC(=O)[C@@H]1CCC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C[C@H](C)NC[S@+]([O-])CCC[C@@H]1CCC[NH2+][C@@H]1C
|
CC[C@H](C)C[C@H](C)NC(=O)[C@@H]1CCC[NH2+][C@@H]1C
|
CC[C@H](C)C[C@H](C)NC[S@+]([O-])CCC[C@@H]1CCC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C24=O"
}
|
Can you make molecule Cc1ccc(C(=O)N2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)N2CCN(CCC(CO)=Nc3c(C)cccc3C)CC2)cc1C
|
Cc1ccc(C(=O)N2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1C
|
Cc1ccc(C(=O)N2CCN(CCC(CO)=Nc3c(C)cccc3C)CC2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C6C5=O"
}
|
Can you make molecule Cc1ccc(C(=O)N2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(CN1CCN(C(=O)c2ccc(C)c(C)c2)CC1)=N/ONc1c(C)cccc1C
|
Cc1ccc(C(=O)N2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1C
|
C/C(CN1CCN(C(=O)c2ccc(C)c(C)c2)CC1)=N/ONc1c(C)cccc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C6C5=O"
}
|
Can you make molecule Cc1ccc(C(=O)N2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CNc1c(C)cccc1C)N1CCN(C(=O)c2ccc(C)c(C)c2)CC1
|
Cc1ccc(C(=O)N2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1C
|
CCC(CC)(C(=O)CNc1c(C)cccc1C)N1CCN(C(=O)c2ccc(C)c(C)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C6C5=O"
}
|
Can you make molecule Cc1ccc(C(=O)N2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)N2CCN(SSC(=O)Nc3c(C)cccc3C)CC2)cc1C
|
Cc1ccc(C(=O)N2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1C
|
Cc1ccc(C(=O)N2CCN(SSC(=O)Nc3c(C)cccc3C)CC2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C6C5=O"
}
|
Can you make molecule Cc1ccc(C(=O)N2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CCNc1c(C)cccc1C)N1CCN(C(=O)c2ccc(C)c(C)c2)CC1
|
Cc1ccc(C(=O)N2CCN(CC(=O)Nc3c(C)cccc3C)CC2)cc1C
|
CCC(CC)(C(=O)CCNc1c(C)cccc1C)N1CCN(C(=O)c2ccc(C)c(C)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C6C5=O"
}
|
Can you make molecule C[C@H]([C@H](C)S(C)(=O)=O)N(C)Cc1ccc([N+](=O)[O-])c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](c1nc(C#N)c(Cc2ccc([N+](=O)[O-])c(O)c2)o1)[C@H](C)S(C)(=O)=O
|
C[C@H]([C@H](C)S(C)(=O)=O)N(C)Cc1ccc([N+](=O)[O-])c(O)c1
|
C[C@@H](c1nc(C#N)c(Cc2ccc([N+](=O)[O-])c(O)c2)o1)[C@H](C)S(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1nc&oc1&",
"old_substring": "N23C"
}
|
Can you make molecule C[C@H]([C@H](C)S(C)(=O)=O)N(C)Cc1ccc([N+](=O)[O-])c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](c1cc(C#N)c(Cc2ccc([N+](=O)[O-])c(O)c2)s1)[C@H](C)S(C)(=O)=O
|
C[C@H]([C@H](C)S(C)(=O)=O)N(C)Cc1ccc([N+](=O)[O-])c(O)c1
|
C[C@@H](c1cc(C#N)c(Cc2ccc([N+](=O)[O-])c(O)c2)s1)[C@H](C)S(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N23C"
}
|
Can you make molecule C[C@H]([C@H](C)S(C)(=O)=O)N(C)Cc1ccc([N+](=O)[O-])c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](c1ccc(Cc2ccc([N+](=O)[O-])c(O)c2)c(C#N)c1)[C@H](C)S(C)(=O)=O
|
C[C@H]([C@H](C)S(C)(=O)=O)N(C)Cc1ccc([N+](=O)[O-])c(O)c1
|
C[C@@H](c1ccc(Cc2ccc([N+](=O)[O-])c(O)c2)c(C#N)c1)[C@H](C)S(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N23C"
}
|
Can you make molecule C[C@H]([C@H](C)S(C)(=O)=O)N(C)Cc1ccc([N+](=O)[O-])c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](ON=C1CCN(Cc2ccc([N+](=O)[O-])c(O)c2)CC1)[C@H](C)S(C)(=O)=O
|
C[C@H]([C@H](C)S(C)(=O)=O)N(C)Cc1ccc([N+](=O)[O-])c(O)c1
|
C[C@@H](ON=C1CCN(Cc2ccc([N+](=O)[O-])c(O)c2)CC1)[C@H](C)S(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "N23C"
}
|
Can you make molecule C[C@H]([C@H](C)S(C)(=O)=O)N(C)Cc1ccc([N+](=O)[O-])c(O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](c1cnc(C#N)c(Cc2ccc([N+](=O)[O-])c(O)c2)c1)[C@H](C)S(C)(=O)=O
|
C[C@H]([C@H](C)S(C)(=O)=O)N(C)Cc1ccc([N+](=O)[O-])c(O)c1
|
C[C@@H](c1cnc(C#N)c(Cc2ccc([N+](=O)[O-])c(O)c2)c1)[C@H](C)S(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1ncc&cc1&",
"old_substring": "N23C"
}
|
Can you make molecule [NH3+]Cc1ccccc1CS(=O)(=O)N1CCN2CCC[C@@H]2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]Cc1ccccc1C[S@+]([O-])CCCC(=O)N1CCN2CCC[C@@H]2C1
|
[NH3+]Cc1ccccc1CS(=O)(=O)N1CCN2CCC[C@@H]2C1
|
[NH3+]Cc1ccccc1C[S@+]([O-])CCCC(=O)N1CCN2CCC[C@@H]2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCCC&=O",
"old_substring": "C5S3(=O)=O"
}
|
Can you make molecule [NH3+]Cc1ccccc1CS(=O)(=O)N1CCN2CCC[C@@H]2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](c1ccccc1C[NH3+])S(=O)(=O)CN1CCN2CCC[C@@H]2C1
|
[NH3+]Cc1ccccc1CS(=O)(=O)N1CCN2CCC[C@@H]2C1
|
C[C@H](c1ccccc1C[NH3+])S(=O)(=O)CN1CCN2CCC[C@@H]2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&S(=O)(=O)C&",
"old_substring": "C5S3(=O)=O"
}
|
Can you make molecule [NH3+]Cc1ccccc1CS(=O)(=O)N1CCN2CCC[C@@H]2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]Cc1ccccc1C[S@@+]([O-])CCCC(=O)N1CCN2CCC[C@@H]2C1
|
[NH3+]Cc1ccccc1CS(=O)(=O)N1CCN2CCC[C@@H]2C1
|
[NH3+]Cc1ccccc1C[S@@+]([O-])CCCC(=O)N1CCN2CCC[C@@H]2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@@](=O)CCCC&=O",
"old_substring": "C5S3(=O)=O"
}
|
Can you make molecule [NH3+]Cc1ccccc1CS(=O)(=O)N1CCN2CCC[C@@H]2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(-c2ccccc2C[NH3+])c1S(=O)(=O)N1CCN2CCC[C@@H]2C1
|
[NH3+]Cc1ccccc1CS(=O)(=O)N1CCN2CCC[C@@H]2C1
|
Cc1cccc(-c2ccccc2C[NH3+])c1S(=O)(=O)N1CCN2CCC[C@@H]2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cccc&c1S&(=O)=O",
"old_substring": "C5S3(=O)=O"
}
|
Can you make molecule [NH3+]Cc1ccccc1CS(=O)(=O)N1CCN2CCC[C@@H]2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]Cc1ccccc1C(=O)CCCC(=O)N1CCN2CCC[C@@H]2C1
|
[NH3+]Cc1ccccc1CS(=O)(=O)N1CCN2CCC[C@@H]2C1
|
[NH3+]Cc1ccccc1C(=O)CCCC(=O)N1CCN2CCC[C@@H]2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C5S3(=O)=O"
}
|
Can you make molecule CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C4(C)CCCC4)cc3)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C4(C)CCCC4)cc3)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CCCC1",
"old_substring": "C8(C)C"
}
|
Can you make molecule CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(Cl)(Cl)Cl)cc3)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(Cl)(Cl)Cl)cc3)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(Cl)(Cl)Cl",
"old_substring": "C8(C)C"
}
|
Can you make molecule CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)(C)c1ccc(NC(=O)c2ccc3c(c2)[nH]c(=O)c(=O)n3CC)cc1
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21
|
CCCC(C)(C)c1ccc(NC(=O)c2ccc3c(c2)[nH]c(=O)c(=O)n3CC)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&(C)C",
"old_substring": "C8(C)C"
}
|
Can you make molecule CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)(CC)CC)cc3)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)(CC)CC)cc3)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(C)CC",
"old_substring": "C8(C)C"
}
|
Can you make molecule CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C4(C=O)CCCCCC4)cc3)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C4(C=O)CCCCCC4)cc3)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C=O)CCCCCC1",
"old_substring": "C8(C)C"
}
|
Can you make molecule COc1ccc(NC(=O)c2oc3ccccc3c2NC(=O)C(C)(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)C(=O)Nc1coc2ccccc12.COc1ccc(NSC2=NC(=O)C=[SH]2)cc1OC
|
COc1ccc(NC(=O)c2oc3ccccc3c2NC(=O)C(C)(C)C)cc1OC
|
CC(C)(C)C(=O)Nc1coc2ccccc12.COc1ccc(NSC2=NC(=O)C=[SH]2)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C1=NC(=O)C=&S1",
"old_substring": "C4%10=O"
}
|
Can you make molecule COc1ccc(NC(=O)c2oc3ccccc3c2NC(=O)C(C)(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)C(=O)Nc1coc2ccccc12.COc1ccc(Nn2nc(C)c(C)cc2=O)cc1OC
|
COc1ccc(NC(=O)c2oc3ccccc3c2NC(=O)C(C)(C)C)cc1OC
|
CC(C)(C)C(=O)Nc1coc2ccccc12.COc1ccc(Nn2nc(C)c(C)cc2=O)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nn&c(=O)c&c1C",
"old_substring": "C4%10=O"
}
|
Can you make molecule COc1ccc(NC(=O)c2oc3ccccc3c2NC(=O)C(C)(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)C(=O)Nc1coc2ccccc12.COc1ccc(NC(=O)n2cc(C#N)cn2)cc1OC
|
COc1ccc(NC(=O)c2oc3ccccc3c2NC(=O)C(C)(C)C)cc1OC
|
CC(C)(C)C(=O)Nc1coc2ccccc12.COc1ccc(NC(=O)n2cc(C#N)cn2)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cn(C&=O)nc1&",
"old_substring": "C4%10=O"
}
|
Can you make molecule COc1ccc(NC(=O)c2oc3ccccc3c2NC(=O)C(C)(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)C(=O)Nc1coc2ccccc12.COc1ccc(NCCC=CO)cc1OC
|
COc1ccc(NC(=O)c2oc3ccccc3c2NC(=O)C(C)(C)C)cc1OC
|
CC(C)(C)C(=O)Nc1coc2ccccc12.COc1ccc(NCCC=CO)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C4%10=O"
}
|
Can you make molecule COc1ccc(NC(=O)c2oc3ccccc3c2NC(=O)C(C)(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)C(=O)Nc1coc2ccccc12.COc1ccc(Nc2c[nH]c(=O)cc2C)cc1OC
|
COc1ccc(NC(=O)c2oc3ccccc3c2NC(=O)C(C)(C)C)cc1OC
|
CC(C)(C)C(=O)Nc1coc2ccccc12.COc1ccc(Nc2c[nH]c(=O)cc2C)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c[nH]c(=O)c1&",
"old_substring": "C4%10=O"
}
|
Can you make molecule CCC[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC12CC([NH+](C3CCC([NH3+])CC3)[C@H]3CCOC3)=CC=CC=C1C2
|
CCC[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1
|
CC12CC([NH+](C3CCC([NH3+])CC3)[C@H]3CCOC3)=CC=CC=C1C2
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1&Cc2ccccc2C1",
"old_substring": "CCC2"
}
|
Can you make molecule CCC[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CCCC2=C(N=C1[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1)S2
|
CCC[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1
|
CC1(C)CCCC2=C(N=C1[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1)S2
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1(C)CCCc2sc&nc21",
"old_substring": "CCC2"
}
|
Can you make molecule CCC[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CC2=CC2=CC=C([NH+](C2CCC([NH3+])CC2)[C@H]2CCOC2)O1
|
CCC[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1
|
CC1(C)CC2=CC2=CC=C([NH+](C2CCC([NH3+])CC2)[C@H]2CCOC2)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1(C)Cc2cc&ccc2O1",
"old_substring": "CCC2"
}
|
Can you make molecule CCC[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN1CCC2=CC2=CC=C1[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1
|
CCC[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1
|
CN1CCC2=CC2=CC=C1[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN1CCc2cc&ccc21",
"old_substring": "CCC2"
}
|
Can you make molecule CCC[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C1CCC([NH+](CCCCC23CC2C3)[C@H]2CCOC2)CC1
|
CCC[NH+](C1CCC([NH3+])CC1)[C@H]1CCOC1
|
[NH3+]C1CCC([NH+](CCCCC23CC2C3)[C@H]2CCOC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC2(CCCC2)C1",
"old_substring": "CCC2"
}
|
Can you make molecule COc1cc(C(=O)Nc2nccs2)ccc1OCCC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)Nc2ccsc2)ccc1OCCC(C)C
|
COc1cc(C(=O)Nc2nccs2)ccc1OCCC(C)C
|
COc1cc(C(=O)Nc2ccsc2)ccc1OCCC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccsc1",
"old_substring": "c17nccs1"
}
|
Can you make molecule COc1cc(C(=O)Nc2nccs2)ccc1OCCC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)Nc2cnc(Br)s2)ccc1OCCC(C)C
|
COc1cc(C(=O)Nc2nccs2)ccc1OCCC(C)C
|
COc1cc(C(=O)Nc2cnc(Br)s2)ccc1OCCC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1ncc&s1",
"old_substring": "c17nccs1"
}
|
Can you make molecule COc1cc(C(=O)Nc2nccs2)ccc1OCCC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)Nc2ncc(Cl)s2)ccc1OCCC(C)C
|
COc1cc(C(=O)Nc2nccs2)ccc1OCCC(C)C
|
COc1cc(C(=O)Nc2ncc(Cl)s2)ccc1OCCC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc(Cl)s1",
"old_substring": "c17nccs1"
}
|
Can you make molecule COc1cc(C(=O)Nc2nccs2)ccc1OCCC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)Nc2ncc(Br)s2)ccc1OCCC(C)C
|
COc1cc(C(=O)Nc2nccs2)ccc1OCCC(C)C
|
COc1cc(C(=O)Nc2ncc(Br)s2)ccc1OCCC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc(Br)s1",
"old_substring": "c17nccs1"
}
|
Can you make molecule COc1cc(C(=O)Nc2nccs2)ccc1OCCC(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)Nc2scnc2Cl)ccc1OCCC(C)C
|
COc1cc(C(=O)Nc2nccs2)ccc1OCCC(C)C
|
COc1cc(C(=O)Nc2scnc2Cl)ccc1OCCC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&scnc1Cl",
"old_substring": "c17nccs1"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)Nc2ccc(CC(=O)SN3[C@@H](C)CCC[C@@H]3C)cc2)cc1
|
Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1
|
Cc1ccc(S(=O)(=O)Nc2ccc(CC(=O)SN3[C@@H](C)CCC[C@@H]3C)cc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)CCCC(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1
|
Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1
|
Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)CCCC(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)Nc2ccc(C(C)(C)CC(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1
|
Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1
|
Cc1ccc(S(=O)(=O)Nc2ccc(C(C)(C)CC(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)Nc2ccc(C(C)(C)CCC(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1
|
Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1
|
Cc1ccc(S(=O)(=O)Nc2ccc(C(C)(C)CCC(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)Nc2ccc([C@H](C)C(=O)SN3[C@@H](C)CCC[C@@H]3C)cc2)cc1
|
Cc1ccc(S(=O)(=O)Nc2ccc(C(=O)N3[C@@H](C)CCC[C@@H]3C)cc2)cc1
|
Cc1ccc(S(=O)(=O)Nc2ccc([C@H](C)C(=O)SN3[C@@H](C)CCC[C@@H]3C)cc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C47=O"
}
|
Can you make molecule COc1cc(Br)ccc1[C@H]([NH3+])C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)ccc1[C@H]([NH3+])CO
|
COc1cc(Br)ccc1[C@H]([NH3+])C(=O)[O-]
|
COc1cc(Br)ccc1[C@H]([NH3+])CO
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH3+][C@@H]3CO",
"old_substring": "[C@@H]3([NH3+])C(=O)[O-]"
}
|
Can you make molecule COc1cc(Br)ccc1[C@H]([NH3+])C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H]([NH3+])Cc1ccc(Br)cc1OC
|
COc1cc(Br)ccc1[C@H]([NH3+])C(=O)[O-]
|
CCCC[C@H]([NH3+])Cc1ccc(Br)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]([NH3+])C3",
"old_substring": "[C@@H]3([NH3+])C(=O)[O-]"
}
|
Can you make molecule COc1cc(Br)ccc1[C@H]([NH3+])C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H]([NH3+])CCc1ccc(Br)cc1OC
|
COc1cc(Br)ccc1[C@H]([NH3+])C(=O)[O-]
|
CCC[C@H]([NH3+])CCc1ccc(Br)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]([NH3+])CC3",
"old_substring": "[C@@H]3([NH3+])C(=O)[O-]"
}
|
Can you make molecule COc1cc(Br)ccc1[C@H]([NH3+])C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)ccc1C[C@H](O)C[NH3+]
|
COc1cc(Br)ccc1[C@H]([NH3+])C(=O)[O-]
|
COc1cc(Br)ccc1C[C@H](O)C[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C3[C@H](O)C[NH3+]",
"old_substring": "[C@@H]3([NH3+])C(=O)[O-]"
}
|
Can you make molecule COc1cc(Br)ccc1[C@H]([NH3+])C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)ccc1N1C[C@H]([NH3+])C1=O
|
COc1cc(Br)ccc1[C@H]([NH3+])C(=O)[O-]
|
COc1cc(Br)ccc1N1C[C@H]([NH3+])C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH3+][C@H]1CN3C1=O",
"old_substring": "[C@@H]3([NH3+])C(=O)[O-]"
}
|
Can you make molecule O=C(OCC1CC1)c1cnc(Oc2ccccc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(OCC1CC1)c1cnc(Oc2ccccc2Cl)cn1
|
O=C(OCC1CC1)c1cnc(Oc2ccccc2)cn1
|
O=C(OCC1CC1)c1cnc(Oc2ccccc2Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c16ccccc1"
}
|
Can you make molecule O=C(OCC1CC1)c1cnc(Oc2ccccc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(OCC1CC1)c1cnc(Oc2ccc(I)cc2)cn1
|
O=C(OCC1CC1)c1cnc(Oc2ccccc2)cn1
|
O=C(OCC1CC1)c1cnc(Oc2ccc(I)cc2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c16ccccc1"
}
|
Can you make molecule O=C(OCC1CC1)c1cnc(Oc2ccccc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Oc2cnc(C(=O)OCC3CC3)cn2)cc1I
|
O=C(OCC1CC1)c1cnc(Oc2ccccc2)cn1
|
Cc1ccc(Oc2cnc(C(=O)OCC3CC3)cn2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c16ccccc1"
}
|
Can you make molecule O=C(OCC1CC1)c1cnc(Oc2ccccc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(OCC1CC1)c1cnc(Oc2cccc(Br)c2)cn1
|
O=C(OCC1CC1)c1cnc(Oc2ccccc2)cn1
|
O=C(OCC1CC1)c1cnc(Oc2cccc(Br)c2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c16ccccc1"
}
|
Can you make molecule O=C(OCC1CC1)c1cnc(Oc2ccccc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(Oc2cnc(C(=O)OCC3CC3)cn2)c1C
|
O=C(OCC1CC1)c1cnc(Oc2ccccc2)cn1
|
Cc1cccc(Oc2cnc(C(=O)OCC3CC3)cn2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c16ccccc1"
}
|
Can you make molecule CC1CC[NH+](CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](CCCCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
|
CC1CC[NH+](CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
|
CC1CC[NH+](CCCCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C6C7"
}
|
Can you make molecule CC1CC[NH+](CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](CCCCCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
|
CC1CC[NH+](CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
|
CC1CC[NH+](CCCCCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C6C7"
}
|
Can you make molecule CC1CC[NH+](CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](C2CC(NC(=O)c3ccc(SCc4cn5ccccc5n4)cc3)C2)CC1
|
CC1CC[NH+](CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
|
CC1CC[NH+](C2CC(NC(=O)c3ccc(SCc4cn5ccccc5n4)cc3)C2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C6C7"
}
|
Can you make molecule CC1CC[NH+](CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+]([C@@H](C)CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
|
CC1CC[NH+](CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
|
CC1CC[NH+]([C@@H](C)CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C6C7"
}
|
Can you make molecule CC1CC[NH+](CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](C2CCC(NC(=O)c3ccc(SCc4cn5ccccc5n4)cc3)CC2)CC1
|
CC1CC[NH+](CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
|
CC1CC[NH+](C2CCC(NC(=O)c3ccc(SCc4cn5ccccc5n4)cc3)CC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C6C7"
}
|
Can you make molecule O=C(CCCn1c(=O)oc2ccccc21)Nc1ccc(Cl)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(n2c(=O)oc3ccccc32)CC1)Nc1ccc(Cl)cc1F
|
O=C(CCCn1c(=O)oc2ccccc21)Nc1ccc(Cl)cc1F
|
O=C(NN=C1CCC(n2c(=O)oc3ccccc32)CC1)Nc1ccc(Cl)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C3CCC5"
}
|
Can you make molecule O=C(CCCn1c(=O)oc2ccccc21)Nc1ccc(Cl)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(Cl)cc1F)C1=CC[C@H](n2c(=O)oc3ccccc32)S1
|
O=C(CCCn1c(=O)oc2ccccc21)Nc1ccc(Cl)cc1F
|
O=C(Nc1ccc(Cl)cc1F)C1=CC[C@H](n2c(=O)oc3ccccc32)S1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&C1=CC[C@H]&S1",
"old_substring": "O=C3CCC5"
}
|
Can you make molecule O=C(CCCn1c(=O)oc2ccccc21)Nc1ccc(Cl)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1oc2ccccc2n1CCCCCNc1ccc(Cl)cc1F
|
O=C(CCCn1c(=O)oc2ccccc21)Nc1ccc(Cl)cc1F
|
O=c1oc2ccccc2n1CCCCCNc1ccc(Cl)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "O=C3CCC5"
}
|
Can you make molecule O=C(CCCn1c(=O)oc2ccccc21)Nc1ccc(Cl)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)Nc1ccc(Cl)cc1F)n1c(=O)oc2ccccc21
|
O=C(CCCn1c(=O)oc2ccccc21)Nc1ccc(Cl)cc1F
|
CC(C)(CCC(=O)Nc1ccc(Cl)cc1F)n1c(=O)oc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "O=C3CCC5"
}
|
Can you make molecule O=C(CCCn1c(=O)oc2ccccc21)Nc1ccc(Cl)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(CCn1c(=O)oc2ccccc21)=Nc1ccc(Cl)cc1F
|
O=C(CCCn1c(=O)oc2ccccc21)Nc1ccc(Cl)cc1F
|
CC(CCn1c(=O)oc2ccccc21)=Nc1ccc(Cl)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C)CC&",
"old_substring": "O=C3CCC5"
}
|
Can you make molecule C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@@H](O)COCc2ccccc2F)C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(OCc1ccccc1F)[C@H](O)CN1C(=O)N[C@](C)(c2ccc(F)cc2)C1=O
|
C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@@H](O)COCc2ccccc2F)C1=O
|
CC(C)(OCc1ccccc1F)[C@H](O)CN1C(=O)N[C@](C)(c2ccc(F)cc2)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[C@@H](O)C&(C)C",
"old_substring": "C5[C@@H](O)C3"
}
|
Can you make molecule C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@@H](O)COCc2ccccc2F)C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CN1C(=O)N[C@](C)(c2ccc(F)cc2)C1=O)C(=O)OCc1ccccc1F
|
C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@@H](O)COCc2ccccc2F)C1=O
|
C[C@H](CN1C(=O)N[C@](C)(c2ccc(F)cc2)C1=O)C(=O)OCc1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[C@@H](C)C&=O",
"old_substring": "C5[C@@H](O)C3"
}
|
Can you make molecule C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@@H](O)COCc2ccccc2F)C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@H](S)COCc2ccccc2F)C1=O
|
C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@@H](O)COCc2ccccc2F)C1=O
|
C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@H](S)COCc2ccccc2F)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[C@H](S)C&",
"old_substring": "C5[C@@H](O)C3"
}
|
Can you make molecule C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@@H](O)COCc2ccccc2F)C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCN1C(=O)N[C@](C)(c2ccc(F)cc2)C1=O)CC(=O)OCc1ccccc1F
|
C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@@H](O)COCc2ccccc2F)C1=O
|
C[C@@H](CCN1C(=O)N[C@](C)(c2ccc(F)cc2)C1=O)CC(=O)OCc1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C5[C@@H](O)C3"
}
|
Can you make molecule C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@@H](O)COCc2ccccc2F)C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CC(=O)N1C(=O)N[C@](C)(c2ccc(F)cc2)C1=O)C(=O)OCc1ccccc1F
|
C[C@]1(c2ccc(F)cc2)NC(=O)N(C[C@@H](O)COCc2ccccc2F)C1=O
|
C[C@@H](CC(=O)N1C(=O)N[C@](C)(c2ccc(F)cc2)C1=O)C(=O)OCc1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&=O)C&=O",
"old_substring": "C5[C@@H](O)C3"
}
|
Can you make molecule C[C@H](OC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](OSC(=O)Cc1ccccc1I)c1nc2ccccc2c(=O)[nH]1
|
C[C@H](OC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
|
C[C@H](OSC(=O)Cc1ccccc1I)c1nc2ccccc2c(=O)[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule C[C@H](OC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](OC(=O)CCCC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
|
C[C@H](OC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
|
C[C@H](OC(=O)CCCC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule C[C@H](OC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](OC(=O)CC(C)(C)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
|
C[C@H](OC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
|
C[C@H](OC(=O)CC(C)(C)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule C[C@H](OC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](OC(=O)CCC(C)(C)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
|
C[C@H](OC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
|
C[C@H](OC(=O)CCC(C)(C)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule C[C@H](OC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](OSC(=O)[C@@H](C)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
|
C[C@H](OC(=O)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
|
C[C@H](OSC(=O)[C@@H](C)c1ccccc1I)c1nc2ccccc2c(=O)[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule COC(=O)c1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1ccc(CC(=O)SNc2ccc(F)c([N+](=O)[O-])c2)cc1
|
COC(=O)c1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1
|
COC(=O)c1ccc(CC(=O)SNc2ccc(F)c([N+](=O)[O-])c2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule COC(=O)c1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1ccc(C(=O)CCCC(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1
|
COC(=O)c1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1
|
COC(=O)c1ccc(C(=O)CCCC(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
}
|
Can you make molecule COC(=O)c1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1ccc(C(C)(C)CC(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1
|
COC(=O)c1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1
|
COC(=O)c1ccc(C(C)(C)CC(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule COC(=O)c1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1ccc(C(C)(C)CCC(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1
|
COC(=O)c1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1
|
COC(=O)c1ccc(C(C)(C)CCC(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule COC(=O)c1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1ccc([C@H](C)C(=O)SNc2ccc(F)c([N+](=O)[O-])c2)cc1
|
COC(=O)c1ccc(C(=O)Nc2ccc(F)c([N+](=O)[O-])c2)cc1
|
COC(=O)c1ccc([C@H](C)C(=O)SNc2ccc(F)c([N+](=O)[O-])c2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C47=O"
}
|
Can you make molecule CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CCCCC2)C1
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCC1",
"old_substring": "C17CC1"
}
|
Can you make molecule CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CC=C2CCCC2)C1
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CC=C2CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCCC1",
"old_substring": "C17CC1"
}
|
Can you make molecule CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2SCCCS2)C1
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2SCCCS2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "C17CC1"
}
|
Can you make molecule CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2SCSCS2)C1
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2SCSCS2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCSCS1",
"old_substring": "C17CC1"
}
|
Can you make molecule CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CC=C2CCCCC2)C1
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CCC2CC2)C1
|
CC(C)C(=O)NC[C@@H]1CCCN(S(=O)(=O)CC=C2CCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCCCC1",
"old_substring": "C17CC1"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)CNc1ccc(OC2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NSC(=O)CNc1ccc(OC2CCCC2)cc1
|
COc1ccc(C)cc1NC(=O)CNc1ccc(OC2CCCC2)cc1
|
COc1ccc(C)cc1NSC(=O)CNc1ccc(OC2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C3(=O)C7"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)CNc1ccc(OC2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NC(=O)CCCC(=O)Nc1ccc(OC2CCCC2)cc1
|
COc1ccc(C)cc1NC(=O)CNc1ccc(OC2CCCC2)cc1
|
COc1ccc(C)cc1NC(=O)CCCC(=O)Nc1ccc(OC2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C3(=O)C7"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)CNc1ccc(OC2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NC(=O)CC(C)(C)Nc1ccc(OC2CCCC2)cc1
|
COc1ccc(C)cc1NC(=O)CNc1ccc(OC2CCCC2)cc1
|
COc1ccc(C)cc1NC(=O)CC(C)(C)Nc1ccc(OC2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C3(=O)C7"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)CNc1ccc(OC2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NC[S@+]([O-])CCCNc1ccc(OC2CCCC2)cc1
|
COc1ccc(C)cc1NC(=O)CNc1ccc(OC2CCCC2)cc1
|
COc1ccc(C)cc1NC[S@+]([O-])CCCNc1ccc(OC2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C3(=O)C7"
}
|
Can you make molecule COc1ccc(C)cc1NC(=O)CNc1ccc(OC2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C)cc1NC(=O)CCC(C)(C)Nc1ccc(OC2CCCC2)cc1
|
COc1ccc(C)cc1NC(=O)CNc1ccc(OC2CCCC2)cc1
|
COc1ccc(C)cc1NC(=O)CCC(C)(C)Nc1ccc(OC2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C3(=O)C7"
}
|
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