prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CC[C@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](CBr)C[C@@H]1CCCC[C@H]([NH2+]C)C1
|
CC[C@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1
|
CC[C@H](CBr)C[C@@H]1CCCC[C@H]([NH2+]C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](C&)CBr",
"old_substring": "CC[C@@H]3C"
}
|
Can you make molecule CC[C@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](CCCl)C[C@@H]1CCCC[C@H]([NH2+]C)C1
|
CC[C@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1
|
CC[C@H](CCCl)C[C@@H]1CCCC[C@H]([NH2+]C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](C&)CCCl",
"old_substring": "CC[C@@H]3C"
}
|
Can you make molecule CC[C@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cl)CCC[C@@H]1CCCC[C@H]([NH2+]C)C1
|
CC[C@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1
|
CC[C@@H](Cl)CCC[C@@H]1CCCC[C@H]([NH2+]C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](Cl)CCC&",
"old_substring": "CC[C@@H]3C"
}
|
Can you make molecule CC[C@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cl)[C@@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1
|
CC[C@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1
|
CC[C@@H](Cl)[C@@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](Cl)[C@H]&C",
"old_substring": "CC[C@@H]3C"
}
|
Can you make molecule CC[C@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CBr)C[C@@H]1CCCC[C@H]([NH2+]C)C1
|
CC[C@H](C)[C@@H]1CCCC[C@H]([NH2+]C)C1
|
CC[C@@H](CBr)C[C@@H]1CCCC[C@H]([NH2+]C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H](C&)CBr",
"old_substring": "CC[C@@H]3C"
}
|
Can you make molecule CCN(C[C@H](C)C#N)C(=O)Nc1cc(F)cc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C[C@H](C)C#N)C(=O)CC(C)(C)Nc1cc(F)cc(Br)c1
|
CCN(C[C@H](C)C#N)C(=O)Nc1cc(F)cc(Br)c1
|
CCN(C[C@H](C)C#N)C(=O)CC(C)(C)Nc1cc(F)cc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CCN(C[C@H](C)C#N)C(=O)Nc1cc(F)cc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C[C@H](C)C#N)C(=O)CCC(C)(C)Nc1cc(F)cc(Br)c1
|
CCN(C[C@H](C)C#N)C(=O)Nc1cc(F)cc(Br)c1
|
CCN(C[C@H](C)C#N)C(=O)CCC(C)(C)Nc1cc(F)cc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CCN(C[C@H](C)C#N)C(=O)Nc1cc(F)cc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C[C@H](C)C#N)C(=O)C[C@@H](Br)Nc1cc(F)cc(Br)c1
|
CCN(C[C@H](C)C#N)C(=O)Nc1cc(F)cc(Br)c1
|
CCN(C[C@H](C)C#N)C(=O)C[C@@H](Br)Nc1cc(F)cc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule CCN(C[C@H](C)C#N)C(=O)Nc1cc(F)cc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C[C@H](C)C#N)c1cc(C)n(Nc2cc(F)cc(Br)c2)c(=O)c1
|
CCN(C[C@H](C)C#N)C(=O)Nc1cc(F)cc(Br)c1
|
CCN(C[C@H](C)C#N)c1cc(C)n(Nc2cc(F)cc(Br)c2)c(=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C23=O"
}
|
Can you make molecule CCN(C[C@H](C)C#N)C(=O)Nc1cc(F)cc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C[C@H](C)C#N)c1c(C)n(Nc2cc(F)cc(Br)c2)ccc1=O
|
CCN(C[C@H](C)C#N)C(=O)Nc1cc(F)cc(Br)c1
|
CCN(C[C@H](C)C#N)c1c(C)n(Nc2cc(F)cc(Br)c2)ccc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C23=O"
}
|
Can you make molecule CC1(C)CCCN(C(=O)NCc2cscn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CCCN(C(=O)NCSCc2cscn2)CC1
|
CC1(C)CCCN(C(=O)NCc2cscn2)CC1
|
CC1(C)CCCN(C(=O)NCSCc2cscn2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N45"
}
|
Can you make molecule CC1(C)CCCN(C(=O)NCc2cscn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CCCN(C(=O)NC(=N)SCc2cscn2)CC1
|
CC1(C)CCCN(C(=O)NCc2cscn2)CC1
|
CC1(C)CCCN(C(=O)NC(=N)SCc2cscn2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N45"
}
|
Can you make molecule CC1(C)CCCN(C(=O)NCc2cscn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)N1CCCC(C)(C)CC1)C(=S)SCc1cscn1
|
CC1(C)CCCN(C(=O)NCc2cscn2)CC1
|
CN(C(=O)N1CCCC(C)(C)CC1)C(=S)SCc1cscn1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N45"
}
|
Can you make molecule CC1(C)CCCN(C(=O)NCc2cscn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CCCN(C(=O)N2CCN=C2SCc2cscn2)CC1
|
CC1(C)CCCN(C(=O)NCc2cscn2)CC1
|
CC1(C)CCCN(C(=O)N2CCN=C2SCc2cscn2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N45"
}
|
Can you make molecule CC1(C)CCCN(C(=O)NCc2cscn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CCCN(C(=O)CN2CCC(Cc3cscn3)CC2)CC1
|
CC1(C)CCCN(C(=O)NCc2cscn2)CC1
|
CC1(C)CCCN(C(=O)CN2CCC(Cc3cscn3)CC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N45"
}
|
Can you make molecule C[C@@]1(C(=O)[O-])CCCCCC[C@@H]1O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@]1(CCS(=O)(=O)[O-])CCCCCC[C@@H]1O
|
C[C@@]1(C(=O)[O-])CCCCCC[C@@H]1O
|
C[C@@]1(CCS(=O)(=O)[O-])CCCCCC[C@@H]1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CS(=O)(=O)[O-]",
"old_substring": "C2(=O)[O-]"
}
|
Can you make molecule C[C@@]1(C(=O)[O-])CCCCCC[C@@H]1O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@]1(C(=O)CO)CCCCCC[C@@H]1O
|
C[C@@]1(C(=O)[O-])CCCCCC[C@@H]1O
|
C[C@@]1(C(=O)CO)CCCCCC[C@@H]1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CO",
"old_substring": "C2(=O)[O-]"
}
|
Can you make molecule C[C@@]1(C(=O)[O-])CCCCCC[C@@H]1O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@]1(C(O)O)CCCCCC[C@@H]1O
|
C[C@@]1(C(=O)[O-])CCCCCC[C@@H]1O
|
C[C@@]1(C(O)O)CCCCCC[C@@H]1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(O)O",
"old_substring": "C2(=O)[O-]"
}
|
Can you make molecule C[C@@]1(C(=O)[O-])CCCCCC[C@@H]1O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@]1(C(F)(F)C(=O)[O-])CCCCCC[C@@H]1O
|
C[C@@]1(C(=O)[O-])CCCCCC[C@@H]1O
|
C[C@@]1(C(F)(F)C(=O)[O-])CCCCCC[C@@H]1O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(F)(F)C(=O)[O-]",
"old_substring": "C2(=O)[O-]"
}
|
Can you make molecule C[C@@]1(C(=O)[O-])CCCCCC[C@@H]1O less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)[O-])[C@]1(C)CCCCCC[C@@H]1O
|
C[C@@]1(C(=O)[O-])CCCCCC[C@@H]1O
|
CCC(CC)(C(=O)[O-])[C@]1(C)CCCCCC[C@@H]1O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)[O-]",
"old_substring": "C2(=O)[O-]"
}
|
Can you make molecule Cc1ncsc1CNc1ncnc2c1CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1CCCCNc1ncnc2c1CCCCC2
|
Cc1ncsc1CNc1ncnc2c1CCCCC2
|
Cc1ncsc1CCCCNc1ncnc2c1CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C35"
}
|
Can you make molecule Cc1ncsc1CNc1ncnc2c1CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1CCC=Nc1ncnc2c1CCCCC2
|
Cc1ncsc1CNc1ncnc2c1CCCCC2
|
Cc1ncsc1CCC=Nc1ncnc2c1CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC&",
"old_substring": "C35"
}
|
Can you make molecule Cc1ncsc1CNc1ncnc2c1CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1CCCCCNc1ncnc2c1CCCCC2
|
Cc1ncsc1CNc1ncnc2c1CCCCC2
|
Cc1ncsc1CCCCCNc1ncnc2c1CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C35"
}
|
Can you make molecule Cc1ncsc1CNc1ncnc2c1CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1C1CC(Nc2ncnc3c2CCCCC3)C1
|
Cc1ncsc1CNc1ncnc2c1CCCCC2
|
Cc1ncsc1C1CC(Nc2ncnc3c2CCCCC3)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C35"
}
|
Can you make molecule Cc1ncsc1CNc1ncnc2c1CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1SC(=S)ONc1ncnc2c1CCCCC2
|
Cc1ncsc1CNc1ncnc2c1CCCCC2
|
Cc1ncsc1SC(=S)ONc1ncnc2c1CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C35"
}
|
Can you make molecule O=C(NCc1cccnc1)c1cc(-c2ccncc2)nc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sc1cc(-c2ccncc2)nc2ccccc12)NCc1cccnc1
|
O=C(NCc1cccnc1)c1cc(-c2ccncc2)nc2ccccc12
|
O=C(/C=C/Sc1cc(-c2ccncc2)nc2ccccc12)NCc1cccnc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(NCc1cccnc1)c1cc(-c2ccncc2)nc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(NCc2cccnc2)nc1-c1cc(-c2ccncc2)nc2ccccc12
|
O=C(NCc1cccnc1)c1cc(-c2ccncc2)nc2ccccc12
|
O=Cc1sc(NCc2cccnc2)nc1-c1cc(-c2ccncc2)nc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(NCc1cccnc1)c1cc(-c2ccncc2)nc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(NCc2cccnc2)sc1-c1cc(-c2ccncc2)nc2ccccc12
|
O=C(NCc1cccnc1)c1cc(-c2ccncc2)nc2ccccc12
|
O=Cc1nc(NCc2cccnc2)sc1-c1cc(-c2ccncc2)nc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(NCc1cccnc1)c1cc(-c2ccncc2)nc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCc1cccnc1)n1nc(-c2cc(-c3ccncc3)nc3ccccc23)oc1=S
|
O=C(NCc1cccnc1)c1cc(-c2ccncc2)nc2ccccc12
|
O=C(NCc1cccnc1)n1nc(-c2cc(-c3ccncc3)nc3ccccc23)oc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&n1nc&oc1=S",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(NCc1cccnc1)c1cc(-c2ccncc2)nc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C(=N/ONCc1cccnc1)\c1ccc(-c2cc(-c3ccncc3)nc3ccccc23)o1
|
O=C(NCc1cccnc1)c1cc(-c2ccncc2)nc2ccccc12
|
C(=N/ONCc1cccnc1)\c1ccc(-c2cc(-c3ccncc3)nc3ccccc23)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C35"
}
|
Can you make molecule CC(C)C[C@H](CO)Nc1ccc([N+](=O)[O-])cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@H](CCO)CNc1ccc([N+](=O)[O-])cc1Cl
|
CC(C)C[C@H](CO)Nc1ccc([N+](=O)[O-])cc1Cl
|
CC(C)C[C@H](CCO)CNc1ccc([N+](=O)[O-])cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)C[C@@H](C&)CCO",
"old_substring": "CC(C)C[C@@H]2CO"
}
|
Can you make molecule CC(C)C[C@H](CO)Nc1ccc([N+](=O)[O-])cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@@H](C#N)Nc1ccc([N+](=O)[O-])cc1Cl
|
CC(C)C[C@H](CO)Nc1ccc([N+](=O)[O-])cc1Cl
|
CC(C)C[C@@H](C#N)Nc1ccc([N+](=O)[O-])cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)C[C@H]&C#N",
"old_substring": "CC(C)C[C@@H]2CO"
}
|
Can you make molecule CC(C)C[C@H](CO)Nc1ccc([N+](=O)[O-])cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)[C@H](C#N)Nc1ccc([N+](=O)[O-])cc1Cl
|
CC(C)C[C@H](CO)Nc1ccc([N+](=O)[O-])cc1Cl
|
CC(C)(C)[C@H](C#N)Nc1ccc([N+](=O)[O-])cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C)[C@@H]&C#N",
"old_substring": "CC(C)C[C@@H]2CO"
}
|
Can you make molecule CC(C)C[C@H](CO)Nc1ccc([N+](=O)[O-])cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@H](C)CC(=O)Nc1ccc([N+](=O)[O-])cc1Cl
|
CC(C)C[C@H](CO)Nc1ccc([N+](=O)[O-])cc1Cl
|
CC(C)C[C@H](C)CC(=O)Nc1ccc([N+](=O)[O-])cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)C[C@H](C)CC&=O",
"old_substring": "CC(C)C[C@@H]2CO"
}
|
Can you make molecule CC(C)C[C@H](CO)Nc1ccc([N+](=O)[O-])cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CCC[C@H](C)Nc1ccc([N+](=O)[O-])cc1Cl
|
CC(C)C[C@H](CO)Nc1ccc([N+](=O)[O-])cc1Cl
|
CC(C)CCC[C@H](C)Nc1ccc([N+](=O)[O-])cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CCC[C@@H]&C",
"old_substring": "CC(C)C[C@@H]2CO"
}
|
Can you make molecule COc1ccc(N)c(SCc2c(Cl)cc(C)nc2Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N)c(SCSCc2c(Cl)cc(C)nc2Cl)c1
|
COc1ccc(N)c(SCc2c(Cl)cc(C)nc2Cl)c1
|
COc1ccc(N)c(SCSCc2c(Cl)cc(C)nc2Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&CS&",
"old_substring": "S46"
}
|
Can you make molecule COc1ccc(N)c(SCc2c(Cl)cc(C)nc2Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N)c(-c2ccc3c(c2)N(Cc2c(Cl)cc(C)nc2Cl)CCS3)c1
|
COc1ccc(N)c(SCc2c(Cl)cc(C)nc2Cl)c1
|
COc1ccc(N)c(-c2ccc3c(c2)N(Cc2c(Cl)cc(C)nc2Cl)CCS3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "S46"
}
|
Can you make molecule COc1ccc(N)c(SCc2c(Cl)cc(C)nc2Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N)c(N/C(C#N)=C(\Cl)SCc2c(Cl)cc(C)nc2Cl)c1
|
COc1ccc(N)c(SCc2c(Cl)cc(C)nc2Cl)c1
|
COc1ccc(N)c(N/C(C#N)=C(\Cl)SCc2c(Cl)cc(C)nc2Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&/C(Cl)=C(\\C#N)N&",
"old_substring": "S46"
}
|
Can you make molecule COc1ccc(N)c(SCc2c(Cl)cc(C)nc2Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N)c(-n2c(=S)n(Cc3c(Cl)cc(C)nc3Cl)c3ccccc32)c1
|
COc1ccc(N)c(SCc2c(Cl)cc(C)nc2Cl)c1
|
COc1ccc(N)c(-n2c(=S)n(Cc3c(Cl)cc(C)nc3Cl)c3ccccc32)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&c(=S)n&c2ccccc21",
"old_substring": "S46"
}
|
Can you make molecule COc1ccc(N)c(SCc2c(Cl)cc(C)nc2Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(N)c([C@H](C)[S@@+]([O-])CCCCc2c(Cl)cc(C)nc2Cl)c1
|
COc1ccc(N)c(SCc2c(Cl)cc(C)nc2Cl)c1
|
COc1ccc(N)c([C@H](C)[S@@+]([O-])CCCCc2c(Cl)cc(C)nc2Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC[S@](=O)[C@H]&C",
"old_substring": "S46"
}
|
Can you make molecule O=C(Cn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1
|
O=C(Cn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1
|
O=C(/C=C/Sn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(Cn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(n2c(=O)c(=O)n(Cc3ccc(Cl)cc3)c3ccccc32)CC1)NC1CCCCC1
|
O=C(Cn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1
|
O=C(NN=C1CCC(n2c(=O)c(=O)n(Cc3ccc(Cl)cc3)c3ccccc32)CC1)NC1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(Cn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\ONC1CCCCC1)C(=O)Sn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21
|
O=C(Cn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1
|
C/C(=N\ONC1CCCCC1)C(=O)Sn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)C(=O)S&",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(Cn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC1CCCCC1)C1=CC[C@H](n2c(=O)c(=O)n(Cc3ccc(Cl)cc3)c3ccccc32)S1
|
O=C(Cn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1
|
O=C(NC1CCCCC1)C1=CC[C@H](n2c(=O)c(=O)n(Cc3ccc(Cl)cc3)c3ccccc32)S1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&C1=CC[C@H]&S1",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(Cn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=Cc1ccc(-n2c(=O)c(=O)n(Cc3ccc(Cl)cc3)c3ccccc32)cc1)NC1CCCCC1
|
O=C(Cn1c(=O)c(=O)n(Cc2ccc(Cl)cc2)c2ccccc21)NC1CCCCC1
|
O=C(NN=Cc1ccc(-n2c(=O)c(=O)n(Cc3ccc(Cl)cc3)c3ccccc32)cc1)NC1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=Cc1ccc&cc1",
"old_substring": "O=C3C5"
}
|
Can you make molecule COc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1
|
COc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1
|
COCc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1
|
COc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1
|
COCSc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1
|
COc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1
|
CC(=O)Sc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1cc(Cl)ccc1C(=O)CS)c1cc2ccccc2o1
|
COc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1
|
O=C(Nc1cc(Cl)ccc1C(=O)CS)c1cc2ccccc2o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1cc(Cl)ccc1C(=O)CI)c1cc2ccccc2o1
|
COc1ccc(Cl)cc1NC(=O)c1cc2ccccc2o1
|
O=C(Nc1cc(Cl)ccc1C(=O)CI)c1cc2ccccc2o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO4"
}
|
Can you make molecule Cc1c(C)c2ccc3c(c2oc1=O)CN(C1CC(C)(C)[NH2+]C(C)(C)C1)CO3 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)(C)CN1COc2ccc3c(C)c(C)c(=O)oc3c2C1
|
Cc1c(C)c2ccc3c(c2oc1=O)CN(C1CC(C)(C)[NH2+]C(C)(C)C1)CO3
|
CCCC(C)(C)CN1COc2ccc3c(C)c(C)c(=O)oc3c2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@](C)(C&)C&",
"old_substring": "C14CC(C)(C)[NH2+]C(C)(C)C1"
}
|
Can you make molecule Cc1c(C)c2ccc3c(c2oc1=O)CN(C1CC(C)(C)[NH2+]C(C)(C)C1)CO3 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)([C@@H](C)N)N1COc2ccc3c(C)c(C)c(=O)oc3c2C1
|
Cc1c(C)c2ccc3c(c2oc1=O)CN(C1CC(C)(C)[NH2+]C(C)(C)C1)CO3
|
CCC(CC)([C@@H](C)N)N1COc2ccc3c(C)c(C)c(=O)oc3c2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)[C@H](N)C&",
"old_substring": "C14CC(C)(C)[NH2+]C(C)(C)C1"
}
|
Can you make molecule Cc1c(C)c2ccc3c(c2oc1=O)CN(C1CC(C)(C)[NH2+]C(C)(C)C1)CO3 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC1CCC12CCN(N1COc3ccc4c(C)c(C)c(=O)oc4c3C1)CC2
|
Cc1c(C)c2ccc3c(c2oc1=O)CN(C1CC(C)(C)[NH2+]C(C)(C)C1)CO3
|
CCC1CCC12CCN(N1COc3ccc4c(C)c(C)c(=O)oc4c3C1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC2(CCC&CC2)CC1",
"old_substring": "C14CC(C)(C)[NH2+]C(C)(C)C1"
}
|
Can you make molecule Cc1c(C)c2ccc3c(c2oc1=O)CN(C1CC(C)(C)[NH2+]C(C)(C)C1)CO3 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C)c2ccc3c(c2oc1=O)CN(N1CCCCCC1)CO3
|
Cc1c(C)c2ccc3c(c2oc1=O)CN(C1CC(C)(C)[NH2+]C(C)(C)C1)CO3
|
Cc1c(C)c2ccc3c(c2oc1=O)CN(N1CCCCCC1)CO3
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC[C@@H]&C1",
"old_substring": "C14CC(C)(C)[NH2+]C(C)(C)C1"
}
|
Can you make molecule Cc1c(C)c2ccc3c(c2oc1=O)CN(C1CC(C)(C)[NH2+]C(C)(C)C1)CO3 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)([C@H](C)N)N1COc2ccc3c(C)c(C)c(=O)oc3c2C1
|
Cc1c(C)c2ccc3c(c2oc1=O)CN(C1CC(C)(C)[NH2+]C(C)(C)C1)CO3
|
CCC(CC)([C@H](C)N)N1COc2ccc3c(C)c(C)c(=O)oc3c2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)[C@@H](N)C&",
"old_substring": "C14CC(C)(C)[NH2+]C(C)(C)C1"
}
|
Can you make molecule CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCCCC2)C1
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCC2)C1
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCCC1",
"old_substring": "C18CCCCC1"
}
|
Can you make molecule CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)SC2=CCCCCC2)C1
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCC2)C1
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)SC2=CCCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(S&)CCCCC1",
"old_substring": "C18CCCCC1"
}
|
Can you make molecule CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCCCCCCCC2)C1
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCC2)C1
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCCCCCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCCCCCCC1",
"old_substring": "C18CCCCC1"
}
|
Can you make molecule CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2(C#N)CCCCCCC2)C1
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCC2)C1
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2(C#N)CCCCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCCCCCC1",
"old_substring": "C18CCCCC1"
}
|
Can you make molecule CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2C3=CC=CC=C2CCCC3)C1
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2CCCCC2)C1
|
CCC(=O)N[C@@H]1CCCN(C(=O)N[C@H](C)C2C3=CC=CC=C2CCCC3)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&C2=CC=CC=C1CCCC2",
"old_substring": "C18CCCCC1"
}
|
Can you make molecule NC(=O)[C@@H]1CCC[C@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)[C@H]1CCC[C@H](NC(=O)Nc2cnn(-c3ccccc3F)c2)CC1
|
NC(=O)[C@@H]1CCC[C@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1
|
NC(=O)[C@H]1CCC[C@H](NC(=O)Nc2cnn(-c3ccccc3F)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&CC1",
"old_substring": "[C@@H]17CCC[C@H]16"
}
|
Can you make molecule NC(=O)[C@@H]1CCC[C@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)[C@H]1CCCC[C@H](NC(=O)Nc2cnn(-c3ccccc3F)c2)C1
|
NC(=O)[C@@H]1CCC[C@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1
|
NC(=O)[C@H]1CCCC[C@H](NC(=O)Nc2cnn(-c3ccccc3F)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@H]&C1",
"old_substring": "[C@@H]17CCC[C@H]16"
}
|
Can you make molecule NC(=O)[C@@H]1CCC[C@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)[C@@H](CBr)CCCNC(=O)Nc1cnn(-c2ccccc2F)c1
|
NC(=O)[C@@H]1CCC[C@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1
|
NC(=O)[C@@H](CBr)CCCNC(=O)Nc1cnn(-c2ccccc2F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@@H]17CCC[C@H]16"
}
|
Can you make molecule NC(=O)[C@@H]1CCC[C@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)CCC1=CCC[C@@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1
|
NC(=O)[C@@H]1CCC[C@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1
|
NC(=O)CCC1=CCC[C@@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC1=CCC[C@@H]1&",
"old_substring": "[C@@H]17CCC[C@H]16"
}
|
Can you make molecule NC(=O)[C@@H]1CCC[C@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)[C@H]1CCc2sc(NC(=O)Nc3cnn(-c4ccccc4F)c3)cc2C1
|
NC(=O)[C@@H]1CCC[C@H]1NC(=O)Nc1cnn(-c2ccccc2F)c1
|
NC(=O)[C@H]1CCc2sc(NC(=O)Nc3cnn(-c4ccccc4F)c3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCc2sc&cc2C1",
"old_substring": "[C@@H]17CCC[C@H]16"
}
|
Can you make molecule Cc1[nH+]cn(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1[nH]nc(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C
|
Cc1[nH+]cn(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C
|
Cc1[nH]nc(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1[nH]nc&c1C",
"old_substring": "Cc1[nH+]cn4c1C"
}
|
Can you make molecule Cc1[nH+]cn(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc[nH]c1C=C[C@H](C)[C@H]1CC[NH+]2CCC[C@H]12
|
Cc1[nH+]cn(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C
|
Cc1nc[nH]c1C=C[C@H](C)[C@H]1CC[NH+]2CCC[C@H]12
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1[nH]cnc1C",
"old_substring": "Cc1[nH+]cn4c1C"
}
|
Can you make molecule Cc1[nH+]cn(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1[nH]c(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)nc(=O)c1C
|
Cc1[nH+]cn(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C
|
Cc1[nH]c(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)nc(=O)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1[nH]c&nc(=O)c1C",
"old_substring": "Cc1[nH+]cn4c1C"
}
|
Can you make molecule Cc1[nH+]cn(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1[nH+]c(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)ccc1I
|
Cc1[nH+]cn(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C
|
Cc1[nH+]c(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)ccc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1[nH+]c&ccc1I",
"old_substring": "Cc1[nH+]cn4c1C"
}
|
Can you make molecule Cc1[nH+]cn(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1[nH+]c(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c2sccn12
|
Cc1[nH+]cn(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c1C
|
Cc1[nH+]c(C[C@H](C)[C@H]2CC[NH+]3CCC[C@H]23)c2sccn12
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1[nH+]c&c2sccn12",
"old_substring": "Cc1[nH+]cn4c1C"
}
|
Can you make molecule Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c(O)cc1Cl
|
Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1
|
Cc1cc(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c(O)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&c(O)cc1Cl",
"old_substring": "Cc1ccc(O)c4c1"
}
|
Can you make molecule Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(O)=NS(=O)(=O)c2cc(F)c(F)c(F)c2)cc1
|
Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1
|
Cc1ccc(C(O)=NS(=O)(=O)c2cc(F)c(F)c(F)c2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(C=&O)cc1",
"old_substring": "Cc1ccc(O)c4c1"
}
|
Can you make molecule Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1
|
Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1
|
Cc1ccc(C)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(C)c&c1",
"old_substring": "Cc1ccc(O)c4c1"
}
|
Can you make molecule Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(I)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1
|
Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1
|
Cc1ccc(I)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(I)c&c1",
"old_substring": "Cc1ccc(O)c4c1"
}
|
Can you make molecule Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Br)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1
|
Cc1ccc(O)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1
|
Cc1ccc(Br)c(NS(=O)(=O)c2cc(F)c(F)c(F)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(Br)c&c1",
"old_substring": "Cc1ccc(O)c4c1"
}
|
Can you make molecule CCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(O)ccc(C(=O)C2=C(C)NC(=O)N[C@H]2c2cc(OC)ccc2O)c2noc1-2
|
CCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O
|
CCc1c(O)ccc(C(=O)C2=C(C)NC(=O)N[C@H]2c2cc(OC)ccc2O)c2noc1-2
| 102
|
{
"fragment_index": 0,
"new_substring": "Oc1ccc2c&noc2c1&",
"old_substring": "O23"
}
|
Can you make molecule CCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc2c(c1)CN(C(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O)CCO2
|
CCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O
|
CCc1ccc2c(c1)CN(C(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O)CCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1",
"old_substring": "O23"
}
|
Can you make molecule CCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cnc2ccc-2cc(C(=O)C2=C(C)NC(=O)N[C@H]2c2cc(OC)ccc2O)c1=O
|
CCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O
|
CCn1cnc2ccc-2cc(C(=O)C2=C(C)NC(=O)N[C@H]2c2cc(OC)ccc2O)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cc&ccc2ncn1&",
"old_substring": "O23"
}
|
Can you make molecule CCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1ccc2nc-2ccc(C(=O)C2=C(C)NC(=O)N[C@H]2c2cc(OC)ccc2O)c1=O
|
CCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O
|
CCn1ccc2nc-2ccc(C(=O)C2=C(C)NC(=O)N[C@H]2c2cc(OC)ccc2O)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2ccc&nc2ccn1&",
"old_substring": "O23"
}
|
Can you make molecule CCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1ccc2nc-2ncc(C(=O)C2=C(C)NC(=O)N[C@H]2c2cc(OC)ccc2O)c1=O
|
CCOC(=O)C1=C(C)NC(=O)N[C@H]1c1cc(OC)ccc1O
|
CCn1ccc2nc-2ncc(C(=O)C2=C(C)NC(=O)N[C@H]2c2cc(OC)ccc2O)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cnc&nc2ccn1&",
"old_substring": "O23"
}
|
Can you make molecule CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)=O)CC3 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(=O)C(C)C)CC3
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)=O)CC3
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(=O)C(C)C)CC3
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)C&=O",
"old_substring": "C4(C)=O"
}
|
Can you make molecule CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)=O)CC3 less soluble in water? The output molecule should be similar to the input molecule.
|
C=C(C)C(=O)N1CCc2c(sc3c2c(=O)n(-c2cc(Cl)ccc2C)c(=O)n3CC)C1
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)=O)CC3
|
C=C(C)C(=O)N1CCc2c(sc3c2c(=O)n(-c2cc(Cl)ccc2C)c(=O)n3CC)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C(C)C&=O",
"old_substring": "C4(C)=O"
}
|
Can you make molecule CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)=O)CC3 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(=O)CC(C)C)CC3
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)=O)CC3
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(=O)CC(C)C)CC3
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&=O",
"old_substring": "C4(C)=O"
}
|
Can you make molecule CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)=O)CC3 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(SC(C)=O)CC3
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)=O)CC3
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(SC(C)=O)CC3
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "C4(C)=O"
}
|
Can you make molecule CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)=O)CC3 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)C)CC3
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)=O)CC3
|
CCn1c(=O)n(-c2cc(Cl)ccc2C)c(=O)c2c3c(sc21)CN(C(C)C)CC3
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "C4(C)=O"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cccc[nH+]4)CC3)CC2)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4ccc(Br)c[nH+]4)CC3)CC2)c(C)c1
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cccc[nH+]4)CC3)CC2)c(C)c1
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4ccc(Br)c[nH+]4)CC3)CC2)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)c[nH+]1",
"old_substring": "c17cccc[nH+]1"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cccc[nH+]4)CC3)CC2)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cc(C)[nH+]c(C)c4)CC3)CC2)c(C)c1
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cccc[nH+]4)CC3)CC2)c(C)c1
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cc(C)[nH+]c(C)c4)CC3)CC2)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(C)[nH+]1",
"old_substring": "c17cccc[nH+]1"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cccc[nH+]4)CC3)CC2)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cc(=O)cc[nH]4)CC3)CC2)c(C)c1
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cccc[nH+]4)CC3)CC2)c(C)c1
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cc(=O)cc[nH]4)CC3)CC2)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(=O)cc[nH]1",
"old_substring": "c17cccc[nH+]1"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cccc[nH+]4)CC3)CC2)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cc5occc5[nH]4)CC3)CC2)c(C)c1
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cccc[nH+]4)CC3)CC2)c(C)c1
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cc5occc5[nH]4)CC3)CC2)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2occc2[nH]1",
"old_substring": "c17cccc[nH+]1"
}
|
Can you make molecule Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cccc[nH+]4)CC3)CC2)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cc5sccc5[nH]4)CC3)CC2)c(C)c1
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cccc[nH+]4)CC3)CC2)c(C)c1
|
Cc1ccc(S(=O)(=O)N2CCC(C(=O)N3CCN(c4cc5sccc5[nH]4)CC3)CC2)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2sccc2[nH]1",
"old_substring": "c17cccc[nH+]1"
}
|
Can you make molecule Cn1cc(C(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(CC(=O)SOC[C@@]2(C)CCCO2)c(-c2cccs2)n1
|
Cn1cc(C(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1
|
Cn1cc(CC(=O)SOC[C@@]2(C)CCCO2)c(-c2cccs2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule Cn1cc(C(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C(=O)CCCC(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1
|
Cn1cc(C(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1
|
Cn1cc(C(=O)CCCC(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule Cn1cc(C(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C(C)(C)CC(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1
|
Cn1cc(C(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1
|
Cn1cc(C(C)(C)CC(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cn1cc(C(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C(C)(C)CCC(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1
|
Cn1cc(C(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1
|
Cn1cc(C(C)(C)CCC(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cn1cc(C(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SOC[C@@]1(C)CCCO1)c1cn(C)nc1-c1cccs1
|
Cn1cc(C(=O)OC[C@@]2(C)CCCO2)c(-c2cccs2)n1
|
C[C@H](C(=O)SOC[C@@]1(C)CCCO1)c1cn(C)nc1-c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F
|
COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F
|
COCc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO4"
}
|
Can you make molecule COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F
|
COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F
|
COCSc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO4"
}
|
Can you make molecule COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(SC(C)=O)c(F)cc1NC(=O)[C@H](C)c1ccc(Cl)s1
|
COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F
|
COc1cc(SC(C)=O)c(F)cc1NC(=O)[C@H](C)c1ccc(Cl)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO4"
}
|
Can you make molecule COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)CS)c(F)cc1NC(=O)[C@H](C)c1ccc(Cl)s1
|
COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F
|
COc1cc(C(=O)CS)c(F)cc1NC(=O)[C@H](C)c1ccc(Cl)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO4"
}
|
Can you make molecule COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C(=O)CI)c(F)cc1NC(=O)[C@H](C)c1ccc(Cl)s1
|
COc1cc(OC)c(NC(=O)[C@H](C)c2ccc(Cl)s2)cc1F
|
COc1cc(C(=O)CI)c(F)cc1NC(=O)[C@H](C)c1ccc(Cl)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO4"
}
|
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