prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Br)c(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1
|
Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1
|
Cc1cc(Br)c(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(Br)c&s1",
"old_substring": "Cc1ccc5s1"
}
|
Can you make molecule Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1csc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)c1Cl
|
Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1
|
Cc1csc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1csc&c1Cl",
"old_substring": "Cc1ccc5s1"
}
|
Can you make molecule Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2sc(-c3cc(O)c4c(c3)CN(C(=O)[C@@H](C)[NH3+])CCO4)cc2c1
|
Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1
|
Cc1ccc2sc(-c3cc(O)c4c(c3)CN(C(=O)[C@@H](C)[NH3+])CCO4)cc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc2sc&cc2c1",
"old_substring": "Cc1ccc5s1"
}
|
Can you make molecule Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)cc1I
|
Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1
|
Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "Cc1ccc5s1"
}
|
Can you make molecule Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1sc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)cc1Br
|
Cc1ccc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)s1
|
Cc1sc(-c2cc(O)c3c(c2)CN(C(=O)[C@@H](C)[NH3+])CCO3)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1sc&cc1Br",
"old_substring": "Cc1ccc5s1"
}
|
Can you make molecule C[C@H](Sc1nnc(-c2ccccc2)o1)C(=O)NC12CC3CC(CC(C3)C1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CCSc1nnc(-c2ccccc2)o1)CC(=O)NC12CC3CC(CC(C3)C1)C2
|
C[C@H](Sc1nnc(-c2ccccc2)o1)C(=O)NC12CC3CC(CC(C3)C1)C2
|
C[C@H](CCSc1nnc(-c2ccccc2)o1)CC(=O)NC12CC3CC(CC(C3)C1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "C[C@H]5C4=O"
}
|
Can you make molecule C[C@H](Sc1nnc(-c2ccccc2)o1)C(=O)NC12CC3CC(CC(C3)C1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCSc1nnc(-c2ccccc2)o1)CC(=O)NC12CC3CC(CC(C3)C1)C2
|
C[C@H](Sc1nnc(-c2ccccc2)o1)C(=O)NC12CC3CC(CC(C3)C1)C2
|
C[C@@H](CCSc1nnc(-c2ccccc2)o1)CC(=O)NC12CC3CC(CC(C3)C1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@H]5C4=O"
}
|
Can you make molecule C[C@H](Sc1nnc(-c2ccccc2)o1)C(=O)NC12CC3CC(CC(C3)C1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCNC12CC3CC(CC(C3)C1)C2)Sc1nnc(-c2ccccc2)o1
|
C[C@H](Sc1nnc(-c2ccccc2)o1)C(=O)NC12CC3CC(CC(C3)C1)C2
|
C[C@@H](CCNC12CC3CC(CC(C3)C1)C2)Sc1nnc(-c2ccccc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C[C@H]5C4=O"
}
|
Can you make molecule C[C@H](Sc1nnc(-c2ccccc2)o1)C(=O)NC12CC3CC(CC(C3)C1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@](CO)(CCCNC12CC3CC(CC(C3)C1)C2)Sc1nnc(-c2ccccc2)o1
|
C[C@H](Sc1nnc(-c2ccccc2)o1)C(=O)NC12CC3CC(CC(C3)C1)C2
|
C[C@](CO)(CCCNC12CC3CC(CC(C3)C1)C2)Sc1nnc(-c2ccccc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@]&(CO)CCC&",
"old_substring": "C[C@H]5C4=O"
}
|
Can you make molecule C[C@H](Sc1nnc(-c2ccccc2)o1)C(=O)NC12CC3CC(CC(C3)C1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(C)(C)NC12CC3CC(CC(C3)C1)C2)Sc1nnc(-c2ccccc2)o1
|
C[C@H](Sc1nnc(-c2ccccc2)o1)C(=O)NC12CC3CC(CC(C3)C1)C2
|
C[C@H](CC(C)(C)NC12CC3CC(CC(C3)C1)C2)Sc1nnc(-c2ccccc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@H]5C4=O"
}
|
Can you make molecule CCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C)c2c1[C@@H]([NH2+]CCC(C)C)[C@@H](C)[C@@H](C)S2(=O)=O
|
CCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C
|
Cc1ccc(C)c2c1[C@@H]([NH2+]CCC(C)C)[C@@H](C)[C@@H](C)S2(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC3"
}
|
Can you make molecule CCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C)c2c1[C@@H]([NH2+]CCCCBr)[C@@H](C)[C@@H](C)S2(=O)=O
|
CCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C
|
Cc1ccc(C)c2c1[C@@H]([NH2+]CCCCBr)[C@@H](C)[C@@H](C)S2(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC3"
}
|
Can you make molecule CCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C
|
CCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C
|
C=CCCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC3"
}
|
Can you make molecule CCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C)c2c1[C@@H]([NH2+]CCCCCl)[C@@H](C)[C@@H](C)S2(=O)=O
|
CCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C
|
Cc1ccc(C)c2c1[C@@H]([NH2+]CCCCCl)[C@@H](C)[C@@H](C)S2(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC3"
}
|
Can you make molecule CCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C
|
CCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C
|
C=CCCCC[NH2+][C@@H]1c2c(C)ccc(C)c2S(=O)(=O)[C@H](C)[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CCC3"
}
|
Can you make molecule O=C(NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C2=CC=CC2=C(NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(F)cc2)CCN1c1ccc(Cl)cc1
|
O=C(NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
|
O=C1C2=CC=CC2=C(NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(F)cc2)CCN1c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1c2cccc&c2CCN1&",
"old_substring": "O=C24"
}
|
Can you make molecule O=C(NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1c(NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(F)cc2)cc(-c2ccc(Cl)cc2)ccc2oc1-2
|
O=C(NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
|
O=Cc1c(NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(F)cc2)cc(-c2ccc(Cl)cc2)ccc2oc1-2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1c&oc2ccc&cc12",
"old_substring": "O=C24"
}
|
Can you make molecule O=C(NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sc1ccc(Cl)cc1)NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1
|
O=C(NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
|
O=C(/C=C/Sc1ccc(Cl)cc1)NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C24"
}
|
Can you make molecule O=C(NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(F)cc2)nc1-c1ccc(Cl)cc1
|
O=C(NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
|
O=Cc1sc(NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(F)cc2)nc1-c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C24"
}
|
Can you make molecule O=C(NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(F)cc2)sc1-c1ccc(Cl)cc1
|
O=C(NC[C@@H](c1cccs1)S(=O)(=O)c1ccc(F)cc1)c1ccc(Cl)cc1
|
O=Cc1nc(NC[C@@H](c2cccs2)S(=O)(=O)c2ccc(F)cc2)sc1-c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C24"
}
|
Can you make molecule CCOc1cc(C[NH+]2CCC[C@H](C(=O)N(CC)CC)C2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)N3CCC(CC)(CC)C3)C2)ccc1O
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)N(CC)CC)C2)ccc1O
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)N3CCC(CC)(CC)C3)C2)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N378"
}
|
Can you make molecule CCOc1cc(C[NH+]2CCC[C@H](C(=O)N(CC)CC)C2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)N3CCCC(CC)(CC)C3)C2)ccc1O
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)N(CC)CC)C2)ccc1O
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)N3CCCC(CC)(CC)C3)C2)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N378"
}
|
Can you make molecule CCOc1cc(C[NH+]2CCC[C@H](C(=O)N(CC)CC)C2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)c3oc(CC)c(CC)c3C#N)C2)ccc1O
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)N(CC)CC)C2)ccc1O
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)c3oc(CC)c(CC)c3C#N)C2)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N378"
}
|
Can you make molecule CCOc1cc(C[NH+]2CCC[C@H](C(=O)N(CC)CC)C2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)N3CC(CC)(CC)CCC3=O)C2)ccc1O
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)N(CC)CC)C2)ccc1O
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)N3CC(CC)(CC)CCC3=O)C2)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC&&CCC1=O",
"old_substring": "N378"
}
|
Can you make molecule CCOc1cc(C[NH+]2CCC[C@H](C(=O)N(CC)CC)C2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)c3nc(CC)nc(CC)c3C#N)C2)ccc1O
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)N(CC)CC)C2)ccc1O
|
CCOc1cc(C[NH+]2CCC[C@H](C(=O)c3nc(CC)nc(CC)c3C#N)C2)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&nc&nc1&",
"old_substring": "N378"
}
|
Can you make molecule CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C(=O)SN1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O
|
CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O
|
CC[C@@H](C(=O)SN1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&N1CCN&CC1",
"old_substring": "N14CCN5CC1"
}
|
Can you make molecule CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C(=O)N1CC(c2cc(Cl)ccc2C)C1)n1nc(C)n2c(cc3occc32)c1=O
|
CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O
|
CC[C@@H](C(=O)N1CC(c2cc(Cl)ccc2C)C1)n1nc(C)n2c(cc3occc32)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC&C1",
"old_substring": "N14CCN5CC1"
}
|
Can you make molecule CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C(=O)N1CCCN(c2cc(Cl)ccc2C)C1=O)n1nc(C)n2c(cc3occc32)c1=O
|
CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O
|
CC[C@@H](C(=O)N1CCCN(c2cc(Cl)ccc2C)C1=O)n1nc(C)n2c(cc3occc32)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCN&C1=O",
"old_substring": "N14CCN5CC1"
}
|
Can you make molecule CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C(=O)N1CCN=C1Sc1cc(Cl)ccc1C)n1nc(C)n2c(cc3occc32)c1=O
|
CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O
|
CC[C@@H](C(=O)N1CCN=C1Sc1cc(Cl)ccc1C)n1nc(C)n2c(cc3occc32)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N14CCN5CC1"
}
|
Can you make molecule CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)C(C)(C)C1)n1nc(C)n2c(cc3occc32)c1=O
|
CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O
|
CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)C(C)(C)C1)n1nc(C)n2c(cc3occc32)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN&C(C)(C)C1",
"old_substring": "N14CCN5CC1"
}
|
Can you make molecule CC[C@H](NC(=O)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](NC(=O)CC(C)(C)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](NC(=O)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](NC(=O)CC(C)(C)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC[C@H](NC(=O)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](NC(=O)CCC(C)(C)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](NC(=O)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](NC(=O)CCC(C)(C)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC[C@H](NC(=O)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](Nc1c(C)n(C)n(NCc2ccc(OC)nc2)c1=O)c1cccc([N+](=O)[O-])c1
|
CC[C@H](NC(=O)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](Nc1c(C)n(C)n(NCc2ccc(OC)nc2)c1=O)c1cccc([N+](=O)[O-])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)n&n1C",
"old_substring": "C23=O"
}
|
Can you make molecule CC[C@H](NC(=O)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](Nc1nn(NCc2ccc(OC)nc2)c(C)cc1=O)c1cccc([N+](=O)[O-])c1
|
CC[C@H](NC(=O)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](Nc1nn(NCc2ccc(OC)nc2)c(C)cc1=O)c1cccc([N+](=O)[O-])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(=O)c&nn1&",
"old_substring": "C23=O"
}
|
Can you make molecule CC[C@H](NC(=O)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](NC(=O)C[C@@H](Br)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](NC(=O)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](NC(=O)C[C@@H](Br)NCc1ccc(OC)nc1)c1cccc([N+](=O)[O-])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule COc1ccc([C@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CCC[C@@H](CCl)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1
|
COc1ccc([C@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1
|
COc1ccc(CCC[C@@H](CCl)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]69C"
}
|
Can you make molecule COc1ccc([C@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CCC2=CN=N[C@H]2N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1
|
COc1ccc([C@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1
|
COc1ccc(CCC2=CN=N[C@H]2N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N=NC=C1CC&",
"old_substring": "[C@@H]69C"
}
|
Can you make molecule COc1ccc([C@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc([C@@H]2CC[C@@H](N(C)C(=O)c3cc(Cc4ccccc4Cl)no3)C2)cc1
|
COc1ccc([C@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1
|
COc1ccc([C@@H]2CC[C@@H](N(C)C(=O)c3cc(Cc4ccccc4Cl)no3)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]69C"
}
|
Can you make molecule COc1ccc([C@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CC(C)(C)[C@@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1
|
COc1ccc([C@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1
|
COc1ccc(CC(C)(C)[C@@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(C)C(C)(C)C&",
"old_substring": "[C@@H]69C"
}
|
Can you make molecule COc1ccc([C@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1ccc(OC)cc1)N(C)C(=O)c1cc(Cc2ccccc2Cl)no1
|
COc1ccc([C@H](C)N(C)C(=O)c2cc(Cc3ccccc3Cl)no2)cc1
|
CC[C@@H](CCc1ccc(OC)cc1)N(C)C(=O)c1cc(Cc2ccccc2Cl)no1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@@H]69C"
}
|
Can you make molecule COc1ccc(-n2nnnc2S[C@@H](C)C(=O)c2cc(C)c(C)cc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-n2nnnc2S[C@@H](CBr)CCc2cc(C)c(C)cc2C)cc1
|
COc1ccc(-n2nnnc2S[C@@H](C)C(=O)c2cc(C)c(C)cc2C)cc1
|
COc1ccc(-n2nnnc2S[C@@H](CBr)CCc2cc(C)c(C)cc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@H]4(C)C5=O"
}
|
Can you make molecule COc1ccc(-n2nnnc2S[C@@H](C)C(=O)c2cc(C)c(C)cc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-n2nnnc2S[C@@H](CBr)CCCc2cc(C)c(C)cc2C)cc1
|
COc1ccc(-n2nnnc2S[C@@H](C)C(=O)c2cc(C)c(C)cc2C)cc1
|
COc1ccc(-n2nnnc2S[C@@H](CBr)CCCc2cc(C)c(C)cc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]4(C)C5=O"
}
|
Can you make molecule COc1ccc(-n2nnnc2S[C@@H](C)C(=O)c2cc(C)c(C)cc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1cc(C)c(C)cc1C)Sc1nnnn1-c1ccc(OC)cc1
|
COc1ccc(-n2nnnc2S[C@@H](C)C(=O)c2cc(C)c(C)cc2C)cc1
|
CC[C@@H](CCc1cc(C)c(C)cc1C)Sc1nnnn1-c1ccc(OC)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@H]4(C)C5=O"
}
|
Can you make molecule COc1ccc(-n2nnnc2S[C@@H](C)C(=O)c2cc(C)c(C)cc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-n2nnnc2S[C@@H](CCl)CCc2cc(C)c(C)cc2C)cc1
|
COc1ccc(-n2nnnc2S[C@@H](C)C(=O)c2cc(C)c(C)cc2C)cc1
|
COc1ccc(-n2nnnc2S[C@@H](CCl)CCc2cc(C)c(C)cc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CCl)CC&",
"old_substring": "[C@H]4(C)C5=O"
}
|
Can you make molecule COc1ccc(-n2nnnc2S[C@@H](C)C(=O)c2cc(C)c(C)cc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(-n2nnnc2S[C@@H](C)CC(C)(C)Cc2cc(C)c(C)cc2C)cc1
|
COc1ccc(-n2nnnc2S[C@@H](C)C(=O)c2cc(C)c(C)cc2C)cc1
|
COc1ccc(-n2nnnc2S[C@@H](C)CC(C)(C)Cc2cc(C)c(C)cc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(C)CC(C)(C)C&",
"old_substring": "[C@H]4(C)C5=O"
}
|
Can you make molecule CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)c1ccc(SCSCC2(CS)CCOCC2)cc1
|
CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1
|
CC(C)(C)c1ccc(SCSCC2(CS)CCOCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&CS&",
"old_substring": "S37"
}
|
Can you make molecule CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)c1ccc(-c2ccc3c(c2)N(CC2(CS)CCOCC2)CCS3)cc1
|
CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1
|
CC(C)(C)c1ccc(-c2ccc3c(c2)N(CC2(CS)CCOCC2)CCS3)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "S37"
}
|
Can you make molecule CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)c1ccc(C(Cl)(Cl)[S@+]([O-])CCC2(CS)CCOCC2)cc1
|
CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1
|
CC(C)(C)c1ccc(C(Cl)(Cl)[S@+]([O-])CCC2(CS)CCOCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=[S@](C&)C&(Cl)Cl",
"old_substring": "S37"
}
|
Can you make molecule CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)c1ccc(N/C(C#N)=C(\Cl)SCC2(CS)CCOCC2)cc1
|
CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1
|
CC(C)(C)c1ccc(N/C(C#N)=C(\Cl)SCC2(CS)CCOCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&/C(Cl)=C(\\C#N)N&",
"old_substring": "S37"
}
|
Can you make molecule CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)c1ccc(-n2c(=S)n(CC3(CS)CCOCC3)c3ccccc32)cc1
|
CC(C)(C)c1ccc(SCC2(CS)CCOCC2)cc1
|
CC(C)(C)c1ccc(-n2c(=S)n(CC3(CS)CCOCC3)c3ccccc32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&c(=S)n&c2ccccc21",
"old_substring": "S37"
}
|
Can you make molecule Cc1cccc(NC(=O)N2CCC3(CC2)OCCO3)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)CC(C)(C)N2CCC3(CC2)OCCO3)c1C
|
Cc1cccc(NC(=O)N2CCC3(CC2)OCCO3)c1C
|
Cc1cccc(NC(=O)CC(C)(C)N2CCC3(CC2)OCCO3)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule Cc1cccc(NC(=O)N2CCC3(CC2)OCCO3)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)CCC(C)(C)N2CCC3(CC2)OCCO3)c1C
|
Cc1cccc(NC(=O)N2CCC3(CC2)OCCO3)c1C
|
Cc1cccc(NC(=O)CCC(C)(C)N2CCC3(CC2)OCCO3)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule Cc1cccc(NC(=O)N2CCC3(CC2)OCCO3)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)C[C@@H](Br)N2CCC3(CC2)OCCO3)c1C
|
Cc1cccc(NC(=O)N2CCC3(CC2)OCCO3)c1C
|
Cc1cccc(NC(=O)C[C@@H](Br)N2CCC3(CC2)OCCO3)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C45=O"
}
|
Can you make molecule Cc1cccc(NC(=O)N2CCC3(CC2)OCCO3)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(Nc2cc(C)n(N3CCC4(CC3)OCCO4)c(=O)c2)c1C
|
Cc1cccc(NC(=O)N2CCC3(CC2)OCCO3)c1C
|
Cc1cccc(Nc2cc(C)n(N3CCC4(CC3)OCCO4)c(=O)c2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C45=O"
}
|
Can you make molecule Cc1cccc(NC(=O)N2CCC3(CC2)OCCO3)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(Nc2c(C)n(N3CCC4(CC3)OCCO4)ccc2=O)c1C
|
Cc1cccc(NC(=O)N2CCC3(CC2)OCCO3)c1C
|
Cc1cccc(Nc2c(C)n(N3CCC4(CC3)OCCO4)ccc2=O)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C45=O"
}
|
Can you make molecule Cc1ccc(F)cc1[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1[C@@H]1CCN(C(C)(C)CC(=O)OC(C)(C)C)C[C@@H]1[NH3+]
|
Cc1ccc(F)cc1[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1[NH3+]
|
Cc1ccc(F)cc1[C@@H]1CCN(C(C)(C)CC(=O)OC(C)(C)C)C[C@@H]1[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule Cc1ccc(F)cc1[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1[C@@H]1CCN(C(C)(C)CCC(=O)OC(C)(C)C)C[C@@H]1[NH3+]
|
Cc1ccc(F)cc1[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1[NH3+]
|
Cc1ccc(F)cc1[C@@H]1CCN(C(C)(C)CCC(=O)OC(C)(C)C)C[C@@H]1[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule Cc1ccc(F)cc1[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1[C@@H]1CCN([C@H](Br)CC(=O)OC(C)(C)C)C[C@@H]1[NH3+]
|
Cc1ccc(F)cc1[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1[NH3+]
|
Cc1ccc(F)cc1[C@@H]1CCN([C@H](Br)CC(=O)OC(C)(C)C)C[C@@H]1[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule Cc1ccc(F)cc1[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
C=C(OOC(C)(C)C)c1ccc(N2CC[C@@H](c3cc(F)ccc3C)[C@@H]([NH3+])C2)cc1
|
Cc1ccc(F)cc1[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1[NH3+]
|
C=C(OOC(C)(C)C)c1ccc(N2CC[C@@H](c3cc(F)ccc3C)[C@@H]([NH3+])C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C(O&)c1ccc&cc1",
"old_substring": "C23=O"
}
|
Can you make molecule Cc1ccc(F)cc1[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(OC(C)(C)C)C(=O)CCN1CC[C@@H](c2cc(F)ccc2C)[C@@H]([NH3+])C1
|
Cc1ccc(F)cc1[C@@H]1CCN(C(=O)OC(C)(C)C)C[C@@H]1[NH3+]
|
CCC(CC)(OC(C)(C)C)C(=O)CCN1CC[C@@H](c2cc(F)ccc2C)[C@@H]([NH3+])C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C23=O"
}
|
Can you make molecule Nc1ccc(Cl)c(S(=O)(=O)N2CCN3C(=O)NC[C@H]3C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCCCN1S(=O)(=O)c1cc(N)ccc1Cl
|
Nc1ccc(Cl)c(S(=O)(=O)N2CCN3C(=O)NC[C@H]3C2)c1
|
C[C@@H]1CCCCN1S(=O)(=O)c1cc(N)ccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC[C@H]1C",
"old_substring": "N14CCN2C(=O)NC[C@H]2C1"
}
|
Can you make molecule Nc1ccc(Cl)c(S(=O)(=O)N2CCN3C(=O)NC[C@H]3C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Nc1ccc(Cl)c(S(=O)(=O)N2CC[C@]3(CCOC3)C2)c1
|
Nc1ccc(Cl)c(S(=O)(=O)N2CCN3C(=O)NC[C@H]3C2)c1
|
Nc1ccc(Cl)c(S(=O)(=O)N2CC[C@]3(CCOC3)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC[C@]2(CCOC2)C1",
"old_substring": "N14CCN2C(=O)NC[C@H]2C1"
}
|
Can you make molecule Nc1ccc(Cl)c(S(=O)(=O)N2CCN3C(=O)NC[C@H]3C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCOCCN1S(=O)(=O)c1cc(N)ccc1Cl
|
Nc1ccc(Cl)c(S(=O)(=O)N2CCN3C(=O)NC[C@H]3C2)c1
|
C[C@@H]1CCOCCN1S(=O)(=O)c1cc(N)ccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOCC[C@H]1C",
"old_substring": "N14CCN2C(=O)NC[C@H]2C1"
}
|
Can you make molecule Nc1ccc(Cl)c(S(=O)(=O)N2CCN3C(=O)NC[C@H]3C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Nc1ccc(Cl)c(S(=O)(=O)N2CCC[C@H](O)CC2)c1
|
Nc1ccc(Cl)c(S(=O)(=O)N2CCN3C(=O)NC[C@H]3C2)c1
|
Nc1ccc(Cl)c(S(=O)(=O)N2CCC[C@H](O)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC[C@H](O)CC1",
"old_substring": "N14CCN2C(=O)NC[C@H]2C1"
}
|
Can you make molecule Nc1ccc(Cl)c(S(=O)(=O)N2CCN3C(=O)NC[C@H]3C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Nc1ccc(Cl)c(S(=O)(=O)N2CCC(O)CC2)c1
|
Nc1ccc(Cl)c(S(=O)(=O)N2CCN3C(=O)NC[C@H]3C2)c1
|
Nc1ccc(Cl)c(S(=O)(=O)N2CCC(O)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC(O)CC1",
"old_substring": "N14CCN2C(=O)NC[C@H]2C1"
}
|
Can you make molecule CC(C)c1nc(NC(=O)N2CCC(Nc3ccccc3F)CC2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1nc(NC(=O)N2CCCc3cc(Nc4ccccc4F)ccc3C2)n(C)n1
|
CC(C)c1nc(NC(=O)N2CCC(Nc3ccccc3F)CC2)n(C)n1
|
CC(C)c1nc(NC(=O)N2CCCc3cc(Nc4ccccc4F)ccc3C2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCc2cc&ccc2C1",
"old_substring": "N15CCC8CC1"
}
|
Can you make molecule CC(C)c1nc(NC(=O)N2CCC(Nc3ccccc3F)CC2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1nc(NC(=O)C2CCC(Nc3ccccc3F)CC2)n(C)n1
|
CC(C)c1nc(NC(=O)N2CCC(Nc3ccccc3F)CC2)n(C)n1
|
CC(C)c1nc(NC(=O)C2CCC(Nc3ccccc3F)CC2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "N15CCC8CC1"
}
|
Can you make molecule CC(C)c1nc(NC(=O)N2CCC(Nc3ccccc3F)CC2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1nc(NC(=O)CCCCCNc2ccccc2F)n(C)n1
|
CC(C)c1nc(NC(=O)N2CCC(Nc3ccccc3F)CC2)n(C)n1
|
CC(C)c1nc(NC(=O)CCCCCNc2ccccc2F)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "N15CCC8CC1"
}
|
Can you make molecule CC(C)c1nc(NC(=O)N2CCC(Nc3ccccc3F)CC2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1nc(NC(=O)C2CCC(=Nc3ccccc3F)CC2)n(C)n1
|
CC(C)c1nc(NC(=O)N2CCC(Nc3ccccc3F)CC2)n(C)n1
|
CC(C)c1nc(NC(=O)C2CCC(=Nc3ccccc3F)CC2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC=&CC1",
"old_substring": "N15CCC8CC1"
}
|
Can you make molecule CC(C)c1nc(NC(=O)N2CCC(Nc3ccccc3F)CC2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1nc(NC(=O)C2CCC(C)(Nc3ccccc3F)CC2)n(C)n1
|
CC(C)c1nc(NC(=O)N2CCC(Nc3ccccc3F)CC2)n(C)n1
|
CC(C)c1nc(NC(=O)C2CCC(C)(Nc3ccccc3F)CC2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&(C)CC1",
"old_substring": "N15CCC8CC1"
}
|
Can you make molecule O=C(Nc1ccc(-c2cscn2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(-c2nc(Br)cs2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
|
O=C(Nc1ccc(-c2cscn2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
|
O=C(Nc1ccc(-c2nc(Br)cs2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1csc&n1",
"old_substring": "c17cscn1"
}
|
Can you make molecule O=C(Nc1ccc(-c2cscn2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(-c2ccsc2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
|
O=C(Nc1ccc(-c2cscn2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
|
O=C(Nc1ccc(-c2ccsc2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccsc1",
"old_substring": "c17cscn1"
}
|
Can you make molecule O=C(Nc1ccc(-c2cscn2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(-c2ccncc2Cl)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
|
O=C(Nc1ccc(-c2cscn2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
|
O=C(Nc1ccc(-c2ccncc2Cl)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccncc1Cl",
"old_substring": "c17cscn1"
}
|
Can you make molecule O=C(Nc1ccc(-c2cscn2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(-c2csc(I)c2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
|
O=C(Nc1ccc(-c2cscn2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
|
O=C(Nc1ccc(-c2csc(I)c2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&csc(I)c1",
"old_substring": "c17cscn1"
}
|
Can you make molecule O=C(Nc1ccc(-c2cscn2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(-c2cnc(Br)s2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
|
O=C(Nc1ccc(-c2cscn2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
|
O=C(Nc1ccc(-c2cnc(Br)s2)cc1)[C@H]1CCCN(C(=O)C2=CCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1ncc&s1",
"old_substring": "c17cscn1"
}
|
Can you make molecule CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)C[NH+](C[C@@H](O)COC(=S)SCc2ccco2)C1(C)C
|
CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C
|
CC1(C)C[NH+](C[C@@H](O)COC(=S)SCc2ccco2)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "O34"
}
|
Can you make molecule CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)C[NH+](C[C@@H](O)C[C@H](O)CCCc2ccco2)C1(C)C
|
CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C
|
CC1(C)C[NH+](C[C@@H](O)C[C@H](O)CCCc2ccco2)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@@H]&CC&",
"old_substring": "O34"
}
|
Can you make molecule CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)C[NH+](C[C@@H](O)CC(=O)/C=C/SCc2ccco2)C1(C)C
|
CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C
|
CC1(C)C[NH+](C[C@@H](O)CC(=O)/C=C/SCc2ccco2)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O34"
}
|
Can you make molecule CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)C[NH+](C[C@@H](O)C[C@H](O)CCCCc2ccco2)C1(C)C
|
CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C
|
CC1(C)C[NH+](C[C@@H](O)C[C@H](O)CCCCc2ccco2)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@@H]&CCC&",
"old_substring": "O34"
}
|
Can you make molecule CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)C[NH+](C[C@@H](O)CCCCC(=O)NOCc2ccco2)C1(C)C
|
CC1(C)C[NH+](C[C@@H](O)COCc2ccco2)C1(C)C
|
CC1(C)C[NH+](C[C@@H](O)CCCCC(=O)NOCc2ccco2)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(CCC&)NO&",
"old_substring": "O34"
}
|
Can you make molecule CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCCNc1cc(C)ccc1C(=O)N(CC)CCCC(F)(F)F
|
CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)F
|
CCCNc1cc(C)ccc1C(=O)N(CC)CCCC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C5C(F)(F)F"
}
|
Can you make molecule CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCCNc1cc(C)ccc1C(=O)N(CC)CCCCC(F)(F)F
|
CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)F
|
CCCNc1cc(C)ccc1C(=O)N(CC)CCCCC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C5C(F)(F)F"
}
|
Can you make molecule CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCCNc1cc(C)ccc1C(=O)N(CC)SC(F)(F)F
|
CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)F
|
CCCNc1cc(C)ccc1C(=O)N(CC)SC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C5C(F)(F)F"
}
|
Can you make molecule CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCCNc1cc(C)ccc1C(=O)N(CC)S/C=C/C(F)(F)F
|
CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)F
|
CCCNc1cc(C)ccc1C(=O)N(CC)S/C=C/C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "S&/C=C/C(F)(F)F",
"old_substring": "C5C(F)(F)F"
}
|
Can you make molecule CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)C(F)(F)F
|
CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)F
|
CCCNc1cc(C)ccc1C(=O)N(CC)CC(F)(F)C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)(F)F",
"old_substring": "C5C(F)(F)F"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(CCC(CO)=C2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
|
C[C@H]1CCCN(C(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
|
C[C@H]1CCCN(CCC(CO)=C2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C34=O"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(SC(=O)CC2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
|
C[C@H]1CCCN(C(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
|
C[C@H]1CCCN(SC(=O)CC2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C34=O"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(CC(=C=O)CC2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
|
C[C@H]1CCCN(C(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
|
C[C@H]1CCCN(CC(=C=O)CC2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C34=O"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C(=O)CCCC(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
|
C[C@H]1CCCN(C(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
|
C[C@H]1CCCN(C(=O)CCCC(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C34=O"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C(=O)CC(C)(C)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
|
C[C@H]1CCCN(C(=O)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
|
C[C@H]1CCCN(C(=O)CC(C)(C)C2C(C)(C)C2(C)C)[C@@H]1C[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CC(C)NC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)NSC(=O)Cc1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
|
CC(C)NC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
|
CC(C)NSC(=O)Cc1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C26=O"
}
|
Can you make molecule CC(C)NC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)NC(=O)CCCC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
|
CC(C)NC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
|
CC(C)NC(=O)CCCC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C26=O"
}
|
Can you make molecule CC(C)NC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)NC(=O)CC(C)(C)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
|
CC(C)NC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
|
CC(C)NC(=O)CC(C)(C)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C26=O"
}
|
Can you make molecule CC(C)NC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)NC(=O)CCC(C)(C)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
|
CC(C)NC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
|
CC(C)NC(=O)CCC(C)(C)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C26=O"
}
|
Can you make molecule CC(C)NC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)NSC(=O)[C@@H](C)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
|
CC(C)NC(=O)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
|
CC(C)NSC(=O)[C@@H](C)c1cc(S(=O)(=O)NC(C)(C)C)ccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C26=O"
}
|
Can you make molecule Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(C)C)cn2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C3(C)CCCC3)cn2)n1
|
Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(C)C)cn2)n1
|
Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C3(C)CCCC3)cn2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CCCC1",
"old_substring": "C6(C)C"
}
|
Can you make molecule Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(C)C)cn2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(Cl)(Cl)Cl)cn2)n1
|
Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(C)C)cn2)n1
|
Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(Cl)(Cl)Cl)cn2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(Cl)(Cl)Cl",
"old_substring": "C6(C)C"
}
|
Can you make molecule Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(C)C)cn2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)(C)n1cnc(S(=O)(=O)N[C@@H](C)Cn2nc(C)cc2C)c1
|
Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(C)C)cn2)n1
|
CCCC(C)(C)n1cnc(S(=O)(=O)N[C@@H](C)Cn2nc(C)cc2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&(C)C",
"old_substring": "C6(C)C"
}
|
Can you make molecule Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(C)C)cn2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(CC)n1cnc(S(=O)(=O)N[C@@H](C)Cn2nc(C)cc2C)c1
|
Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(C)C)cn2)n1
|
CCC(C)(CC)n1cnc(S(=O)(=O)N[C@@H](C)Cn2nc(C)cc2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(C)CC",
"old_substring": "C6(C)C"
}
|
Can you make molecule Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(C)C)cn2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C3(C=O)CCCCCC3)cn2)n1
|
Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C(C)C)cn2)n1
|
Cc1cc(C)n(C[C@H](C)NS(=O)(=O)c2cn(C3(C=O)CCCCCC3)cn2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C=O)CCCCCC1",
"old_substring": "C6(C)C"
}
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.