prompt stringlengths 120 209 | completion stringlengths 15 103 | input_smiles stringlengths 14 103 | output_smiles stringlengths 15 103 | task_id int64 102 102 | winner_action dict |
|---|---|---|---|---|---|
Can you make molecule COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)n1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)c1 | COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)n1 | COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&csc&c1",
"old_substring": "c18csc7n1"
} |
Can you make molecule COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)n1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)c1C | COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)n1 | COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)c1C | 102 | {
"fragment_index": 0,
"new_substring": "c1&csc&c1C",
"old_substring": "c18csc7n1"
} |
Can you make molecule COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)n1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C)cc1-c1ccc(NC(=O)COC2CCCC2)s1 | COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)n1 | COc1ccc(C)cc1-c1ccc(NC(=O)COC2CCCC2)s1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc&s1",
"old_substring": "c18csc7n1"
} |
Can you make molecule COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)n1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C)cc1-c1cc(NC(=O)COC2CCCC2)cnc1Cl | COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)n1 | COc1ccc(C)cc1-c1cc(NC(=O)COC2CCCC2)cnc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&cnc1Cl",
"old_substring": "c18csc7n1"
} |
Can you make molecule COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)n1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C)cc1-c1cc(NC(=O)COC2CCCC2)ncc1Cl | COc1ccc(C)cc1-c1csc(NC(=O)COC2CCCC2)n1 | COc1ccc(C)cc1-c1cc(NC(=O)COC2CCCC2)ncc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&ncc1Cl",
"old_substring": "c18csc7n1"
} |
Can you make molecule COc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C less soluble in water? The output molecule should be similar to the input molecule. | COCc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C | COc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C | COCc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C | 102 | {
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO6"
} |
Can you make molecule COc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C less soluble in water? The output molecule should be similar to the input molecule. | COCSc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C | COc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C | COCSc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C | 102 | {
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO6"
} |
Can you make molecule COc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)Sc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C | COc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C | CC(=O)Sc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C | 102 | {
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO6"
} |
Can you make molecule COc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C less soluble in water? The output molecule should be similar to the input molecule. | CC1=C(C(=O)Nc2ccc(C)cc2C)[C@H](c2ccc(OC(C)C)c(C(=O)CS)c2)n2ncnc2N1 | COc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C | CC1=C(C(=O)Nc2ccc(C)cc2C)[C@H](c2ccc(OC(C)C)c(C(=O)CS)c2)n2ncnc2N1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO6"
} |
Can you make molecule COc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C less soluble in water? The output molecule should be similar to the input molecule. | CC1=C(C(=O)Nc2ccc(C)cc2C)[C@H](c2ccc(OC(C)C)c(C(=O)CI)c2)n2ncnc2N1 | COc1cc([C@H]2C(C(=O)Nc3ccc(C)cc3C)=C(C)Nc3ncnn32)ccc1OC(C)C | CC1=C(C(=O)Nc2ccc(C)cc2C)[C@H](c2ccc(OC(C)C)c(C(=O)CI)c2)n2ncnc2N1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO6"
} |
Can you make molecule COc1cccc2cc(C(=O)C=Cc3ccccc3F)oc12 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc2cc(C(=O)C3=C(N=Cc4ccccc4F)CCS3)oc12 | COc1cccc2cc(C(=O)C=Cc3ccccc3F)oc12 | COc1cccc2cc(C(=O)C3=C(N=Cc4ccccc4F)CCS3)oc12 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C1=C(N&)CCS1",
"old_substring": "C5(=O)C=6"
} |
Can you make molecule COc1cccc2cc(C(=O)C=Cc3ccccc3F)oc12 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc2cc(C(=O)C(N=Cc3ccccc3F)=C(Cl)Cl)oc12 | COc1cccc2cc(C(=O)C=Cc3ccccc3F)oc12 | COc1cccc2cc(C(=O)C(N=Cc3ccccc3F)=C(Cl)Cl)oc12 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C(N&)=C(Cl)Cl",
"old_substring": "C5(=O)C=6"
} |
Can you make molecule COc1cccc2cc(C(=O)C=Cc3ccccc3F)oc12 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc2cc(C(=O)C(C=Cc3ccccc3F)=C(Cl)Cl)oc12 | COc1cccc2cc(C(=O)C=Cc3ccccc3F)oc12 | COc1cccc2cc(C(=O)C(C=Cc3ccccc3F)=C(Cl)Cl)oc12 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C(C&)=C(Cl)Cl",
"old_substring": "C5(=O)C=6"
} |
Can you make molecule COc1cccc2cc(C(=O)C=Cc3ccccc3F)oc12 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc2cc(C(=O)[C@H](C)CC=Cc3ccccc3F)oc12 | COc1cccc2cc(C(=O)C=Cc3ccccc3F)oc12 | COc1cccc2cc(C(=O)[C@H](C)CC=Cc3ccccc3F)oc12 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)[C@H](C)CC&",
"old_substring": "C5(=O)C=6"
} |
Can you make molecule COc1cccc2cc(C(=O)C=Cc3ccccc3F)oc12 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc2cc(C(=O)C(C)(C)CCC=Cc3ccccc3F)oc12 | COc1cccc2cc(C(=O)C=Cc3ccccc3F)oc12 | COc1cccc2cc(C(=O)C(C)(C)CCC=Cc3ccccc3F)oc12 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)CCC&",
"old_substring": "C5(=O)C=6"
} |
Can you make molecule CC[C@H](Oc1ccc(C)nc1C[NH3+])C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | CC[C@@H](C(=O)[O-])c1ccc(O)c(-c2ccc(C)nc2C[NH3+])c2onc1-2 | CC[C@H](Oc1ccc(C)nc1C[NH3+])C(=O)[O-] | CC[C@@H](C(=O)[O-])c1ccc(O)c(-c2ccc(C)nc2C[NH3+])c2onc1-2 | 102 | {
"fragment_index": 0,
"new_substring": "Oc1ccc2c&noc2c1&",
"old_substring": "O23"
} |
Can you make molecule CC[C@H](Oc1ccc(C)nc1C[NH3+])C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | CC[C@@H](C(=O)[O-])N1CCOc2ccc(-c3ccc(C)nc3C[NH3+])cc2C1 | CC[C@H](Oc1ccc(C)nc1C[NH3+])C(=O)[O-] | CC[C@@H](C(=O)[O-])N1CCOc2ccc(-c3ccc(C)nc3C[NH3+])cc2C1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1",
"old_substring": "O23"
} |
Can you make molecule CC[C@H](Oc1ccc(C)nc1C[NH3+])C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | CC[C@@H](C(=O)[O-])c1cc2ccc-2ncn(-c2ccc(C)nc2C[NH3+])c1=O | CC[C@H](Oc1ccc(C)nc1C[NH3+])C(=O)[O-] | CC[C@@H](C(=O)[O-])c1cc2ccc-2ncn(-c2ccc(C)nc2C[NH3+])c1=O | 102 | {
"fragment_index": 0,
"new_substring": "O=c1c2cc&ccc2ncn1&",
"old_substring": "O23"
} |
Can you make molecule CC[C@H](Oc1ccc(C)nc1C[NH3+])C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | CC[C@@H](C(=O)[O-])c1ccc2nc-2ccn(-c2ccc(C)nc2C[NH3+])c1=O | CC[C@H](Oc1ccc(C)nc1C[NH3+])C(=O)[O-] | CC[C@@H](C(=O)[O-])c1ccc2nc-2ccn(-c2ccc(C)nc2C[NH3+])c1=O | 102 | {
"fragment_index": 0,
"new_substring": "O=c1c2ccc&nc2ccn1&",
"old_substring": "O23"
} |
Can you make molecule CC[C@H](Oc1ccc(C)nc1C[NH3+])C(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | CC[C@@H](C(=O)[O-])c1cnc2nc-2ccn(-c2ccc(C)nc2C[NH3+])c1=O | CC[C@H](Oc1ccc(C)nc1C[NH3+])C(=O)[O-] | CC[C@@H](C(=O)[O-])c1cnc2nc-2ccn(-c2ccc(C)nc2C[NH3+])c1=O | 102 | {
"fragment_index": 0,
"new_substring": "O=c1c2cnc&nc2ccn1&",
"old_substring": "O23"
} |
Can you make molecule O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3)cc2C(=O)N1C[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule. | O=C1c2ccc(Oc3ccc(NC(=O)C(F)(F)F)cc3I)cc2C(=O)N1C[C@H]1CCCO1 | O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3)cc2C(=O)N1C[C@H]1CCCO1 | O=C1c2ccc(Oc3ccc(NC(=O)C(F)(F)F)cc3I)cc2C(=O)N1C[C@H]1CCCO1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c16cccc7c1"
} |
Can you make molecule O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3)cc2C(=O)N1C[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule. | O=C1c2ccc(Oc3cc(NC(=O)C(F)(F)F)ccc3Br)cc2C(=O)N1C[C@H]1CCCO1 | O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3)cc2C(=O)N1C[C@H]1CCCO1 | O=C1c2ccc(Oc3cc(NC(=O)C(F)(F)F)ccc3Br)cc2C(=O)N1C[C@H]1CCCO1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c16cccc7c1"
} |
Can you make molecule O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3)cc2C(=O)N1C[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule. | O=C1c2ccc(Oc3ccc(NC(=O)C(F)(F)F)cc3Cl)cc2C(=O)N1C[C@H]1CCCO1 | O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3)cc2C(=O)N1C[C@H]1CCCO1 | O=C1c2ccc(Oc3ccc(NC(=O)C(F)(F)F)cc3Cl)cc2C(=O)N1C[C@H]1CCCO1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c16cccc7c1"
} |
Can you make molecule O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3)cc2C(=O)N1C[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule. | O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3Br)cc2C(=O)N1C[C@H]1CCCO1 | O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3)cc2C(=O)N1C[C@H]1CCCO1 | O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3Br)cc2C(=O)N1C[C@H]1CCCO1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c16cccc7c1"
} |
Can you make molecule O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3)cc2C(=O)N1C[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule. | O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3Cl)cc2C(=O)N1C[C@H]1CCCO1 | O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3)cc2C(=O)N1C[C@H]1CCCO1 | O=C1c2ccc(Oc3cccc(NC(=O)C(F)(F)F)c3Cl)cc2C(=O)N1C[C@H]1CCCO1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c16cccc7c1"
} |
Can you make molecule CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2I)c1 | CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2)c1 | CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2I)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17ccc6cc1"
} |
Can you make molecule CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1cccc(O[C@H](C)C(=O)Nc2cc(OC)ccc2Br)c1 | CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2)c1 | CCc1cccc(O[C@H](C)C(=O)Nc2cc(OC)ccc2Br)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17ccc6cc1"
} |
Can you make molecule CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2Cl)c1 | CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2)c1 | CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2Cl)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17ccc6cc1"
} |
Can you make molecule CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1cccc(O[C@H](C)C(=O)Nc2cccc(OC)c2Br)c1 | CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2)c1 | CCc1cccc(O[C@H](C)C(=O)Nc2cccc(OC)c2Br)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17ccc6cc1"
} |
Can you make molecule CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1cccc(O[C@H](C)C(=O)Nc2cccc(OC)c2Cl)c1 | CCc1cccc(O[C@H](C)C(=O)Nc2ccc(OC)cc2)c1 | CCc1cccc(O[C@H](C)C(=O)Nc2cccc(OC)c2Cl)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17ccc6cc1"
} |
Can you make molecule COc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 less soluble in water? The output molecule should be similar to the input molecule. | COCc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 | COc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 | COCc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 | 102 | {
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO6"
} |
Can you make molecule COc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 less soluble in water? The output molecule should be similar to the input molecule. | COCSc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 | COc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 | COCSc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 | 102 | {
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO6"
} |
Can you make molecule COc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(SC(C)=O)cc1[C@H]1OC(COc2ccc3c(c2)OCO3)=NN1C(C)=O | COc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 | COc1ccc(SC(C)=O)cc1[C@H]1OC(COc2ccc3c(c2)OCO3)=NN1C(C)=O | 102 | {
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO6"
} |
Can you make molecule COc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C(=O)CS)cc1[C@H]1OC(COc2ccc3c(c2)OCO3)=NN1C(C)=O | COc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 | COc1ccc(C(=O)CS)cc1[C@H]1OC(COc2ccc3c(c2)OCO3)=NN1C(C)=O | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO6"
} |
Can you make molecule COc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(C(=O)CI)cc1[C@H]1OC(COc2ccc3c(c2)OCO3)=NN1C(C)=O | COc1ccc(OC)c([C@H]2OC(COc3ccc4c(c3)OCO4)=NN2C(C)=O)c1 | COc1ccc(C(=O)CI)cc1[C@H]1OC(COc2ccc3c(c2)OCO3)=NN1C(C)=O | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO6"
} |
Can you make molecule CCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule. | C=CSn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F | CCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F | C=CSn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F | 102 | {
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC4"
} |
Can you make molecule CCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(-c2ccc([C@@H](O)C(F)(F)F)n2C(C)C)cc1 | CCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F | COc1ccc(-c2ccc([C@@H](O)C(F)(F)F)n2C(C)C)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC4"
} |
Can you make molecule CCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule. | C=CCCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F | CCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F | C=CCCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F | 102 | {
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC4"
} |
Can you make molecule CCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(-c2ccc([C@@H](O)C(F)(F)F)n2CCCCl)cc1 | CCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F | COc1ccc(-c2ccc([C@@H](O)C(F)(F)F)n2CCCCl)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC4"
} |
Can you make molecule CCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule. | COc1ccc(-c2ccc([C@@H](O)C(F)(F)F)n2CCCCS)cc1 | CCn1c(-c2ccc(OC)cc2)ccc1[C@@H](O)C(F)(F)F | COc1ccc(-c2ccc([C@@H](O)C(F)(F)F)n2CCCCS)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC4"
} |
Can you make molecule CC[NH+]1CCC[C@@H]1C[NH+](C)CCC(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | C[NH+](CCC(=O)[O-])C[C@H]1CCC[NH+]1C1(C)Cc2ccccc2C1 | CC[NH+]1CCC[C@@H]1C[NH+](C)CCC(=O)[O-] | C[NH+](CCC(=O)[O-])C[C@H]1CCC[NH+]1C1(C)Cc2ccccc2C1 | 102 | {
"fragment_index": 0,
"new_substring": "CC1&Cc2ccccc2C1",
"old_substring": "CC2"
} |
Can you make molecule CC[NH+]1CCC[C@@H]1C[NH+](C)CCC(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | C[NH+](CCC(=O)[O-])C[C@H]1CCC[NH+]1C1=CC2=CC=C2OC(C)(C)C1 | CC[NH+]1CCC[C@@H]1C[NH+](C)CCC(=O)[O-] | C[NH+](CCC(=O)[O-])C[C@H]1CCC[NH+]1C1=CC2=CC=C2OC(C)(C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "CC1(C)Cc2cc&ccc2O1",
"old_substring": "CC2"
} |
Can you make molecule CC[NH+]1CCC[C@@H]1C[NH+](C)CCC(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | C[NH+](CCC(=O)[O-])C[C@H]1CCC[NH+]1N1CC(C)(C)Oc2ccccc21 | CC[NH+]1CCC[C@@H]1C[NH+](C)CCC(=O)[O-] | C[NH+](CCC(=O)[O-])C[C@H]1CCC[NH+]1N1CC(C)(C)Oc2ccccc21 | 102 | {
"fragment_index": 0,
"new_substring": "CC1(C)CN&c2ccccc2O1",
"old_substring": "CC2"
} |
Can you make molecule CC[NH+]1CCC[C@@H]1C[NH+](C)CCC(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | C[NH+](CCC(=O)[O-])C[C@H]1CCC[NH+]1N1CC(C)(C)Sc2ccccc21 | CC[NH+]1CCC[C@@H]1C[NH+](C)CCC(=O)[O-] | C[NH+](CCC(=O)[O-])C[C@H]1CCC[NH+]1N1CC(C)(C)Sc2ccccc21 | 102 | {
"fragment_index": 0,
"new_substring": "CC1(C)CN&c2ccccc2S1",
"old_substring": "CC2"
} |
Can you make molecule CC[NH+]1CCC[C@@H]1C[NH+](C)CCC(=O)[O-] less soluble in water? The output molecule should be similar to the input molecule. | C[NH+](CCC(=O)[O-])C[C@H]1CCC[NH+]1C1C2CCC1CC2 | CC[NH+]1CCC[C@@H]1C[NH+](C)CCC(=O)[O-] | C[NH+](CCC(=O)[O-])C[C@H]1CCC[NH+]1C1C2CCC1CC2 | 102 | {
"fragment_index": 0,
"new_substring": "C1&C2CCC1CC2",
"old_substring": "CC2"
} |
Can you make molecule C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1ccc(S(C)(=O)=O)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](CC(C)(C)c1ccc(S(C)(=O)=O)c(F)c1)NC(=O)C[C@H](O)c1ccccc1 | C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1ccc(S(C)(=O)=O)c(F)c1 | C[C@H](CC(C)(C)c1ccc(S(C)(=O)=O)c(F)c1)NC(=O)C[C@H](O)c1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@H]34"
} |
Can you make molecule C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1ccc(S(C)(=O)=O)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](CCNC(=O)C[C@H](O)c1ccccc1)CC(=O)c1ccc(S(C)(=O)=O)c(F)c1 | C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1ccc(S(C)(=O)=O)c(F)c1 | C[C@H](CCNC(=O)C[C@H](O)c1ccccc1)CC(=O)c1ccc(S(C)(=O)=O)c(F)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "C[C@H]34"
} |
Can you make molecule C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1ccc(S(C)(=O)=O)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](Cc1ccc(S(C)(=O)=O)c(F)c1)[C@H](C)NC(=O)C[C@H](O)c1ccccc1 | C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1ccc(S(C)(=O)=O)c(F)c1 | C[C@H](Cc1ccc(S(C)(=O)=O)c(F)c1)[C@H](C)NC(=O)C[C@H](O)c1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@H]&[C@H](C)C&",
"old_substring": "C[C@H]34"
} |
Can you make molecule C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1ccc(S(C)(=O)=O)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](CCNC(=O)C[C@H](O)c1ccccc1)CC(=O)c1ccc(S(C)(=O)=O)c(F)c1 | C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1ccc(S(C)(=O)=O)c(F)c1 | C[C@@H](CCNC(=O)C[C@H](O)c1ccccc1)CC(=O)c1ccc(S(C)(=O)=O)c(F)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@H]34"
} |
Can you make molecule C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1ccc(S(C)(=O)=O)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule. | CCC[C@@H](CCc1ccc(S(C)(=O)=O)c(F)c1)NC(=O)C[C@H](O)c1ccccc1 | C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1ccc(S(C)(=O)=O)c(F)c1 | CCC[C@@H](CCc1ccc(S(C)(=O)=O)c(F)c1)NC(=O)C[C@H](O)c1ccccc1 | 102 | {
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&",
"old_substring": "C[C@H]34"
} |
Can you make molecule C[C@H](C(=O)OCC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | C/C(COC(=O)[C@@H](C)c1cccs1)=N/ON(C)[C@@H]1CCCc2ccccc21 | C[C@H](C(=O)OCC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 | C/C(COC(=O)[C@@H](C)c1cccs1)=N/ON(C)[C@@H]1CCCc2ccccc21 | 102 | {
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C5C4=O"
} |
Can you make molecule C[C@H](C(=O)OCC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | CCC(CC)(OC(=O)[C@@H](C)c1cccs1)C(=O)CN(C)[C@@H]1CCCc2ccccc21 | C[C@H](C(=O)OCC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 | CCC(CC)(OC(=O)[C@@H](C)c1cccs1)C(=O)CN(C)[C@@H]1CCCc2ccccc21 | 102 | {
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C5C4=O"
} |
Can you make molecule C[C@H](C(=O)OCC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](C(=O)OSSC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 | C[C@H](C(=O)OCC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 | C[C@H](C(=O)OSSC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 | 102 | {
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C5C4=O"
} |
Can you make molecule C[C@H](C(=O)OCC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | CCC(CC)(OC(=O)[C@@H](C)c1cccs1)C(=O)CCN(C)[C@@H]1CCCc2ccccc21 | C[C@H](C(=O)OCC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 | CCC(CC)(OC(=O)[C@@H](C)c1cccs1)C(=O)CCN(C)[C@@H]1CCCc2ccccc21 | 102 | {
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C5C4=O"
} |
Can you make molecule C[C@H](C(=O)OCC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | CC[C@H](C(=O)OC(=O)[C@@H](C)c1cccs1)C(=O)N(C)[C@@H]1CCCc2ccccc21 | C[C@H](C(=O)OCC(=O)N(C)[C@@H]1CCCc2ccccc21)c1cccs1 | CC[C@H](C(=O)OC(=O)[C@@H](C)c1cccs1)C(=O)N(C)[C@@H]1CCCc2ccccc21 | 102 | {
"fragment_index": 0,
"new_substring": "CC[C@H](C&=O)C&=O",
"old_substring": "C5C4=O"
} |
Can you make molecule CCN[C@H]1CCCC[C@@H]1[NH+](C)Cc1cccc(C)n1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cccc(C[NH+](C)[C@H]2CCCC[C@@H]2NC2=CC=CC=C3CC3(C)C2)n1 | CCN[C@H]1CCCC[C@@H]1[NH+](C)Cc1cccc(C)n1 | Cc1cccc(C[NH+](C)[C@H]2CCCC[C@@H]2NC2=CC=CC=C3CC3(C)C2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "CC1&Cc2ccccc2C1",
"old_substring": "CC2"
} |
Can you make molecule CCN[C@H]1CCCC[C@@H]1[NH+](C)Cc1cccc(C)n1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cccc(C[NH+](C)[C@H]2CCCC[C@@H]2NC2=NC3=C(CCCC2(C)C)S3)n1 | CCN[C@H]1CCCC[C@@H]1[NH+](C)Cc1cccc(C)n1 | Cc1cccc(C[NH+](C)[C@H]2CCCC[C@@H]2NC2=NC3=C(CCCC2(C)C)S3)n1 | 102 | {
"fragment_index": 0,
"new_substring": "CC1(C)CCCc2sc&nc21",
"old_substring": "CC2"
} |
Can you make molecule CCN[C@H]1CCCC[C@@H]1[NH+](C)Cc1cccc(C)n1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cccc(C[NH+](C)[C@H]2CCCC[C@@H]2NC2=CC=C3C=C3CC(C)(C)O2)n1 | CCN[C@H]1CCCC[C@@H]1[NH+](C)Cc1cccc(C)n1 | Cc1cccc(C[NH+](C)[C@H]2CCCC[C@@H]2NC2=CC=C3C=C3CC(C)(C)O2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "CC1(C)Cc2cc&ccc2O1",
"old_substring": "CC2"
} |
Can you make molecule CCN[C@H]1CCCC[C@@H]1[NH+](C)Cc1cccc(C)n1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cccc(C[NH+](C)[C@H]2CCCC[C@@H]2NC2=CC=C3C=C3CCN2C)n1 | CCN[C@H]1CCCC[C@@H]1[NH+](C)Cc1cccc(C)n1 | Cc1cccc(C[NH+](C)[C@H]2CCCC[C@@H]2NC2=CC=C3C=C3CCN2C)n1 | 102 | {
"fragment_index": 0,
"new_substring": "CN1CCc2cc&ccc21",
"old_substring": "CC2"
} |
Can you make molecule CCN[C@H]1CCCC[C@@H]1[NH+](C)Cc1cccc(C)n1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cccc(C[NH+](C)[C@H]2CCCC[C@@H]2NCCCCC23CC2C3)n1 | CCN[C@H]1CCCC[C@@H]1[NH+](C)Cc1cccc(C)n1 | Cc1cccc(C[NH+](C)[C@H]2CCCC[C@@H]2NCCCCC23CC2C3)n1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&CC2(CCCC2)C1",
"old_substring": "CC2"
} |
Can you make molecule COc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COCc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC | COc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC | COCc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC | 102 | {
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO3"
} |
Can you make molecule COc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COCSc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC | COc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC | COCSc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC | 102 | {
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
} |
Can you make molecule COc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(C(=O)CCCC2OCC(C)(C)CO2)ccc1SC(C)=O | COc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC | COc1cc(C(=O)CCCC2OCC(C)(C)CO2)ccc1SC(C)=O | 102 | {
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
} |
Can you make molecule COc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(C(=O)CCCC2OCC(C)(C)CO2)ccc1C(=O)CS | COc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC | COc1cc(C(=O)CCCC2OCC(C)(C)CO2)ccc1C(=O)CS | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO3"
} |
Can you make molecule COc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(C(=O)CCCC2OCC(C)(C)CO2)ccc1C(=O)CI | COc1ccc(C(=O)CCCC2OCC(C)(C)CO2)cc1OC | COc1cc(C(=O)CCCC2OCC(C)(C)CO2)ccc1C(=O)CI | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
} |
Can you make molecule Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1F less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(C(=O)NNc2cccc(C(F)(F)F)c2)c(Cl)cc1F | Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1F | Cc1cc(C(=O)NNc2cccc(C(F)(F)F)c2)c(Cl)cc1F | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&c(Cl)cc1F",
"old_substring": "Cc1ccc3cc1F"
} |
Can you make molecule Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1F less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1Cl | Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1F | Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1Cl",
"old_substring": "Cc1ccc3cc1F"
} |
Can you make molecule Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1F less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(F)c(C(=O)NNc2cccc(C(F)(F)F)c2)c1Cl | Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1F | Cc1ccc(F)c(C(=O)NNc2cccc(C(F)(F)F)c2)c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "Cc1ccc(F)c&c1Cl",
"old_substring": "Cc1ccc3cc1F"
} |
Can you make molecule Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1F less soluble in water? The output molecule should be similar to the input molecule. | Cc1ccc(Br)c(C(=O)NNc2cccc(C(F)(F)F)c2)c1 | Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1F | Cc1ccc(Br)c(C(=O)NNc2cccc(C(F)(F)F)c2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "Cc1ccc(Br)c&c1",
"old_substring": "Cc1ccc3cc1F"
} |
Can you make molecule Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1F less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(C(=O)NNc2cccc(C(F)(F)F)c2)c(C)cc1I | Cc1ccc(C(=O)NNc2cccc(C(F)(F)F)c2)cc1F | Cc1cc(C(=O)NNc2cccc(C(F)(F)F)c2)c(C)cc1I | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&c(C)cc1I",
"old_substring": "Cc1ccc3cc1F"
} |
Can you make molecule COc1ccc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)cc1I | COc1ccc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c1 | COc1cc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)cc1I | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1I",
"old_substring": "c14ccc5c8c1"
} |
Can you make molecule COc1ccc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)cc1Cl | COc1ccc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c1 | COc1cc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)cc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1Cl",
"old_substring": "c14ccc5c8c1"
} |
Can you make molecule COc1ccc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(I)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c(OC)c1 | COc1ccc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c1 | COc1cc(I)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c(OC)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&cc(I)c1&",
"old_substring": "c14ccc5c8c1"
} |
Can you make molecule COc1ccc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cc(Br)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c(OC)c1 | COc1ccc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c1 | COc1cc(Br)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c(OC)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&c&c(Br)c1",
"old_substring": "c14ccc5c8c1"
} |
Can you make molecule COc1ccc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cc([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c(OC)cc1Br | COc1ccc(OC)c([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c1 | COc1cc([C@H](c2nnnn2C2CCCC2)N2CCc3ccccc3C2)c(OC)cc1Br | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc(Br)c&cc1&",
"old_substring": "c14ccc5c8c1"
} |
Can you make molecule C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)N(C)c2ccc(F)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCCCN1S(=O)(=O)c1cccc(CC(=O)SN(C)c2ccc(F)cc2)c1 | C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)N(C)c2ccc(F)cc2)c1 | C[C@H]1CCCCN1S(=O)(=O)c1cccc(CC(=O)SN(C)c2ccc(F)cc2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
} |
Can you make molecule C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)N(C)c2ccc(F)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)CCCC(=O)N(C)c2ccc(F)cc2)c1 | C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)N(C)c2ccc(F)cc2)c1 | C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)CCCC(=O)N(C)c2ccc(F)cc2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
} |
Can you make molecule C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)N(C)c2ccc(F)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(C)(C)CC(=O)N(C)c2ccc(F)cc2)c1 | C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)N(C)c2ccc(F)cc2)c1 | C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(C)(C)CC(=O)N(C)c2ccc(F)cc2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
} |
Can you make molecule C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)N(C)c2ccc(F)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(C)(C)CCC(=O)N(C)c2ccc(F)cc2)c1 | C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)N(C)c2ccc(F)cc2)c1 | C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(C)(C)CCC(=O)N(C)c2ccc(F)cc2)c1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C36=O"
} |
Can you make molecule C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)N(C)c2ccc(F)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](C(=O)SN(C)c1ccc(F)cc1)c1cccc(S(=O)(=O)N2CCCC[C@@H]2C)c1 | C[C@H]1CCCCN1S(=O)(=O)c1cccc(C(=O)N(C)c2ccc(F)cc2)c1 | C[C@H](C(=O)SN(C)c1ccc(F)cc1)c1cccc(S(=O)(=O)N2CCCC[C@@H]2C)c1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C36=O"
} |
Can you make molecule C[C@H](O)C[C@H]1CCCN1C(=O)NCC1(C)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](O)C[C@H]1CCCN1C(=O)CC(C)(C)NCC1(C)Cc2ccccc2C1 | C[C@H](O)C[C@H]1CCCN1C(=O)NCC1(C)Cc2ccccc2C1 | C[C@H](O)C[C@H]1CCCN1C(=O)CC(C)(C)NCC1(C)Cc2ccccc2C1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
} |
Can you make molecule C[C@H](O)C[C@H]1CCCN1C(=O)NCC1(C)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](O)C[C@H]1CCCN1C(=O)CCC(C)(C)NCC1(C)Cc2ccccc2C1 | C[C@H](O)C[C@H]1CCCN1C(=O)NCC1(C)Cc2ccccc2C1 | C[C@H](O)C[C@H]1CCCN1C(=O)CCC(C)(C)NCC1(C)Cc2ccccc2C1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
} |
Can you make molecule C[C@H](O)C[C@H]1CCCN1C(=O)NCC1(C)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](O)C[C@H]1CCCN1C(=O)C[C@@H](Br)NCC1(C)Cc2ccccc2C1 | C[C@H](O)C[C@H]1CCCN1C(=O)NCC1(C)Cc2ccccc2C1 | C[C@H](O)C[C@H]1CCCN1C(=O)C[C@@H](Br)NCC1(C)Cc2ccccc2C1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
} |
Can you make molecule C[C@H](O)C[C@H]1CCCN1C(=O)NCC1(C)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(N2CCC[C@@H]2C[C@H](C)O)cc(=O)n1NCC1(C)Cc2ccccc2C1 | C[C@H](O)C[C@H]1CCCN1C(=O)NCC1(C)Cc2ccccc2C1 | Cc1cc(N2CCC[C@@H]2C[C@H](C)O)cc(=O)n1NCC1(C)Cc2ccccc2C1 | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C34=O"
} |
Can you make molecule C[C@H](O)C[C@H]1CCCN1C(=O)NCC1(C)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1c(N2CCC[C@@H]2C[C@H](C)O)c(=O)ccn1NCC1(C)Cc2ccccc2C1 | C[C@H](O)C[C@H]1CCCN1C(=O)NCC1(C)Cc2ccccc2C1 | Cc1c(N2CCC[C@@H]2C[C@H](C)O)c(=O)ccn1NCC1(C)Cc2ccccc2C1 | 102 | {
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C34=O"
} |
Can you make molecule O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCOCC1 | O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCO1 | O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCOCC1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CCCOCC1",
"old_substring": "[C@H]17CCCO1"
} |
Can you make molecule O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(NCCc1nnc2ccccn12)NC[C@H]1CSCCS1 | O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCO1 | O=C(NCCc1nnc2ccccn12)NC[C@H]1CSCCS1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CSCCS1",
"old_substring": "[C@H]17CCCO1"
} |
Can you make molecule O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(NCCc1nnc2ccccn12)NC[C@H]1CC=CS1 | O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCO1 | O=C(NCCc1nnc2ccccn12)NC[C@H]1CC=CS1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CC=CS1",
"old_substring": "[C@H]17CCCO1"
} |
Can you make molecule O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(NCCc1nnc2ccccn12)NC[C@@H]1CCSC1 | O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCO1 | O=C(NCCc1nnc2ccccn12)NC[C@@H]1CCSC1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]1&CCSC1",
"old_substring": "[C@H]17CCCO1"
} |
Can you make molecule O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(NCCc1nnc2ccccn12)NC[C@H]1CC12CCOCC2 | O=C(NCCc1nnc2ccccn12)NC[C@H]1CCCO1 | O=C(NCCc1nnc2ccccn12)NC[C@H]1CC12CCOCC2 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CC12CCOCC2",
"old_substring": "[C@H]17CCCO1"
} |
Can you make molecule CC1CCN(C(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CC1CCN(SC(=O)Cc2ccccc2NC(=O)NCCc2cccs2)CC1 | CC1CCN(C(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 | CC1CCN(SC(=O)Cc2ccccc2NC(=O)NCCc2cccs2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C38=O"
} |
Can you make molecule CC1CCN(C(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CC1CCN(C(=O)CCCC(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 | CC1CCN(C(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 | CC1CCN(C(=O)CCCC(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C38=O"
} |
Can you make molecule CC1CCN(C(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CC1CCN(C(=O)CC(C)(C)c2ccccc2NC(=O)NCCc2cccs2)CC1 | CC1CCN(C(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 | CC1CCN(C(=O)CC(C)(C)c2ccccc2NC(=O)NCCc2cccs2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C38=O"
} |
Can you make molecule CC1CCN(C(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CC1CCN(C(=O)CCC(C)(C)c2ccccc2NC(=O)NCCc2cccs2)CC1 | CC1CCN(C(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 | CC1CCN(C(=O)CCC(C)(C)c2ccccc2NC(=O)NCCc2cccs2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C38=O"
} |
Can you make molecule CC1CCN(C(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CC1CCN(SC(=O)[C@@H](C)c2ccccc2NC(=O)NCCc2cccs2)CC1 | CC1CCN(C(=O)c2ccccc2NC(=O)NCCc2cccs2)CC1 | CC1CCN(SC(=O)[C@@H](C)c2ccccc2NC(=O)NCCc2cccs2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C38=O"
} |
Can you make molecule CCCCn1c(N)c(N(C)C(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O less soluble in water? The output molecule should be similar to the input molecule. | CCCCn1c(N)c(N(C)SC(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O | CCCCn1c(N)c(N(C)C(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O | CCCCn1c(N)c(N(C)SC(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C3(=O)C4"
} |
Can you make molecule CCCCn1c(N)c(N(C)C(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O less soluble in water? The output molecule should be similar to the input molecule. | CCCCn1c(N)c(N(C)C(=O)CCCC(=O)Sc2ccc(F)cc2)c(=O)[nH]c1=O | CCCCn1c(N)c(N(C)C(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O | CCCCn1c(N)c(N(C)C(=O)CCCC(=O)Sc2ccc(F)cc2)c(=O)[nH]c1=O | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C3(=O)C4"
} |
Can you make molecule CCCCn1c(N)c(N(C)C(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O less soluble in water? The output molecule should be similar to the input molecule. | CCCCn1c(N)c(N(C)C(=O)CC(C)(C)Sc2ccc(F)cc2)c(=O)[nH]c1=O | CCCCn1c(N)c(N(C)C(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O | CCCCn1c(N)c(N(C)C(=O)CC(C)(C)Sc2ccc(F)cc2)c(=O)[nH]c1=O | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C3(=O)C4"
} |
Can you make molecule CCCCn1c(N)c(N(C)C(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O less soluble in water? The output molecule should be similar to the input molecule. | CCCCn1c(N)c(N(C)C[S@+]([O-])CCCSc2ccc(F)cc2)c(=O)[nH]c1=O | CCCCn1c(N)c(N(C)C(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O | CCCCn1c(N)c(N(C)C[S@+]([O-])CCCSc2ccc(F)cc2)c(=O)[nH]c1=O | 102 | {
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C3(=O)C4"
} |
Can you make molecule CCCCn1c(N)c(N(C)C(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O less soluble in water? The output molecule should be similar to the input molecule. | CCCCn1c(N)c(N(C)C(=O)CCC(C)(C)Sc2ccc(F)cc2)c(=O)[nH]c1=O | CCCCn1c(N)c(N(C)C(=O)CSc2ccc(F)cc2)c(=O)[nH]c1=O | CCCCn1c(N)c(N(C)C(=O)CCC(C)(C)Sc2ccc(F)cc2)c(=O)[nH]c1=O | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C3(=O)C4"
} |
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