prompt stringlengths 120 209 | completion stringlengths 15 103 | input_smiles stringlengths 14 103 | output_smiles stringlengths 15 103 | task_id int64 102 102 | winner_action dict |
|---|---|---|---|---|---|
Can you make molecule C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CC1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CCCCC1 | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CC1 | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CCCCC1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&CCCCC1",
"old_substring": "C15CC1"
} |
Can you make molecule C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CC1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1SCCCS1 | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CC1 | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1SCCCS1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "C15CC1"
} |
Can you make molecule C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CC1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1SCSCS1 | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CC1 | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1SCSCS1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&SCSCS1",
"old_substring": "C15CC1"
} |
Can you make molecule C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CC1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CCCCCC1 | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CC1 | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CCCCCC1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&CCCCCC1",
"old_substring": "C15CC1"
} |
Can you make molecule C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CC1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CSCCSC1 | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CC1 | C[C@@H](OC(=O)c1cc(S(C)(=O)=O)ccc1Cl)C1CSCCSC1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&CSCCSC1",
"old_substring": "C15CC1"
} |
Can you make molecule CC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCCC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | CC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | CCCC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "CCCC&=O",
"old_substring": "CC8=O"
} |
Can you make molecule CC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCCCC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | CC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | CCCCC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CC8=O"
} |
Can you make molecule CC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)CCCc1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | CC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | CC(=O)CCCc1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "CC(=O)CCC&",
"old_substring": "CC8=O"
} |
Can you make molecule CC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCC(=O)CCCc1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | CC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | CCC(=O)CCCc1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "CCC(=O)CCC&",
"old_substring": "CC8=O"
} |
Can you make molecule CC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCCCC(=O)Cc1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | CC(=O)c1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | CCCCC(=O)Cc1ccc(Oc2ccc(C(=O)NC[C@H]3CC[NH+](C)C3)cc2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "CCCCC(=O)C&",
"old_substring": "CC8=O"
} |
Can you make molecule CSCC(=O)NNC(=O)NC[C@@]1([NH+](C)C)CCC[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCC[C@@](CNC(=O)NNC(=O)CC2SCCS2)([NH+](C)C)C1 | CSCC(=O)NNC(=O)NC[C@@]1([NH+](C)C)CCC[C@H](C)C1 | C[C@H]1CCC[C@@](CNC(=O)NNC(=O)CC2SCCS2)([NH+](C)C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&SCCS1",
"old_substring": "CS5"
} |
Can you make molecule CSCC(=O)NNC(=O)NC[C@@]1([NH+](C)C)CCC[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCC[C@@](CNC(=O)NNC(=O)CC2SCCCS2)([NH+](C)C)C1 | CSCC(=O)NNC(=O)NC[C@@]1([NH+](C)C)CCC[C@H](C)C1 | C[C@H]1CCC[C@@](CNC(=O)NNC(=O)CC2SCCCS2)([NH+](C)C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "CS5"
} |
Can you make molecule CSCC(=O)NNC(=O)NC[C@@]1([NH+](C)C)CCC[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCC[C@@](CNC(=O)NNC(=O)CC2(C)SCCS2)([NH+](C)C)C1 | CSCC(=O)NNC(=O)NC[C@@]1([NH+](C)C)CCC[C@H](C)C1 | C[C@H]1CCC[C@@](CNC(=O)NNC(=O)CC2(C)SCCS2)([NH+](C)C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "CC1&SCCS1",
"old_substring": "CS5"
} |
Can you make molecule CSCC(=O)NNC(=O)NC[C@@]1([NH+](C)C)CCC[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCC[C@@](CNC(=O)NNC(=O)CC2SCSCS2)([NH+](C)C)C1 | CSCC(=O)NNC(=O)NC[C@@]1([NH+](C)C)CCC[C@H](C)C1 | C[C@H]1CCC[C@@](CNC(=O)NNC(=O)CC2SCSCS2)([NH+](C)C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&SCSCS1",
"old_substring": "CS5"
} |
Can you make molecule CSCC(=O)NNC(=O)NC[C@@]1([NH+](C)C)CCC[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H]1CCC[C@@](CNC(=O)NNC(=O)CC2CSCCSC2)([NH+](C)C)C1 | CSCC(=O)NNC(=O)NC[C@@]1([NH+](C)C)CCC[C@H](C)C1 | C[C@H]1CCC[C@@](CNC(=O)NNC(=O)CC2CSCCSC2)([NH+](C)C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&CSCCSC1",
"old_substring": "CS5"
} |
Can you make molecule CCc1ccc(-c2ccc(C(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1ccc(-c2ccc(CC(=O)SN3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | CCc1ccc(-c2ccc(C(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | CCc1ccc(-c2ccc(CC(=O)SN3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C45=O"
} |
Can you make molecule CCc1ccc(-c2ccc(C(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1ccc(-c2ccc(C(=O)CCCC(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | CCc1ccc(-c2ccc(C(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | CCc1ccc(-c2ccc(C(=O)CCCC(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C45=O"
} |
Can you make molecule CCc1ccc(-c2ccc(C(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1ccc(-c2ccc(C(C)(C)CC(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | CCc1ccc(-c2ccc(C(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | CCc1ccc(-c2ccc(C(C)(C)CC(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C45=O"
} |
Can you make molecule CCc1ccc(-c2ccc(C(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1ccc(-c2ccc(C(C)(C)CCC(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | CCc1ccc(-c2ccc(C(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | CCc1ccc(-c2ccc(C(C)(C)CCC(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C45=O"
} |
Can you make molecule CCc1ccc(-c2ccc(C(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule. | CCc1ccc(-c2ccc([C@H](C)C(=O)SN3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | CCc1ccc(-c2ccc(C(=O)N3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | CCc1ccc(-c2ccc([C@H](C)C(=O)SN3CCS(=O)(=O)C[C@@H]3C)o2)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C45=O"
} |
Can you make molecule C[C@H](NC(=O)CSc1ccc(Cl)cc1N)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](CC(C)(C)c1cccs1)NC(=O)CSc1ccc(Cl)cc1N | C[C@H](NC(=O)CSc1ccc(Cl)cc1N)c1cccs1 | C[C@H](CC(C)(C)c1cccs1)NC(=O)CSc1ccc(Cl)cc1N | 102 | {
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@H]35"
} |
Can you make molecule C[C@H](NC(=O)CSc1ccc(Cl)cc1N)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](CCNC(=O)CSc1ccc(Cl)cc1N)CC(=O)c1cccs1 | C[C@H](NC(=O)CSc1ccc(Cl)cc1N)c1cccs1 | C[C@H](CCNC(=O)CSc1ccc(Cl)cc1N)CC(=O)c1cccs1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "C[C@H]35"
} |
Can you make molecule C[C@H](NC(=O)CSc1ccc(Cl)cc1N)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](Cc1cccs1)[C@H](C)NC(=O)CSc1ccc(Cl)cc1N | C[C@H](NC(=O)CSc1ccc(Cl)cc1N)c1cccs1 | C[C@H](Cc1cccs1)[C@H](C)NC(=O)CSc1ccc(Cl)cc1N | 102 | {
"fragment_index": 0,
"new_substring": "C[C@H]&[C@H](C)C&",
"old_substring": "C[C@H]35"
} |
Can you make molecule C[C@H](NC(=O)CSc1ccc(Cl)cc1N)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@H](CCNC(=O)CSc1ccc(Cl)cc1N)CC(=O)c1cccs1 | C[C@H](NC(=O)CSc1ccc(Cl)cc1N)c1cccs1 | C[C@@H](CCNC(=O)CSc1ccc(Cl)cc1N)CC(=O)c1cccs1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@H]35"
} |
Can you make molecule C[C@H](NC(=O)CSc1ccc(Cl)cc1N)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | CCC[C@@H](CCc1cccs1)NC(=O)CSc1ccc(Cl)cc1N | C[C@H](NC(=O)CSc1ccc(Cl)cc1N)c1cccs1 | CCC[C@@H](CCc1cccs1)NC(=O)CSc1ccc(Cl)cc1N | 102 | {
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&",
"old_substring": "C[C@H]35"
} |
Can you make molecule CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CCCCC(N)=O)nc2)n1 | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CCCCC(N)=O)nc2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCC(N)=O",
"old_substring": "C5C(N)=O"
} |
Can you make molecule CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=S)nc2)n1 | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=S)nc2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "C&C(N)=S",
"old_substring": "C5C(N)=O"
} |
Can you make molecule CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=O)C[C@@H]1CCCCN1c1ccc(-c2nc(C(C)C)no2)cn1 | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 | CC(=O)C[C@@H]1CCCCN1c1ccc(-c2nc(C(C)C)no2)cn1 | 102 | {
"fragment_index": 0,
"new_substring": "C&C(C)=O",
"old_substring": "C5C(N)=O"
} |
Can you make molecule CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC/C(N)=N/O)nc2)n1 | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC/C(N)=N/O)nc2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "C&C/C(N)=N/O",
"old_substring": "C5C(N)=O"
} |
Can you make molecule CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC/C(N)=N\O)nc2)n1 | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC(N)=O)nc2)n1 | CC(C)c1noc(-c2ccc(N3CCCC[C@H]3CC/C(N)=N\O)nc2)n1 | 102 | {
"fragment_index": 0,
"new_substring": "C&C/C(N)=N\\O",
"old_substring": "C5C(N)=O"
} |
Can you make molecule CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3CCCC[C@@H]3I)CC2)C1 | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)C1 | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3CCCC[C@@H]3I)CC2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@@H]1I",
"old_substring": "[C@H]19C[C@H]1C"
} |
Can you make molecule CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3CC3(Cl)Cl)CC2)C1 | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)C1 | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3CC3(Cl)Cl)CC2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CC1(Cl)Cl",
"old_substring": "[C@H]19C[C@H]1C"
} |
Can you make molecule CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3CC34CCCC4)CC2)C1 | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)C1 | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3CC34CCCC4)CC2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CC12CCCC2",
"old_substring": "[C@H]19C[C@H]1C"
} |
Can you make molecule CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3CC34CCCCC4)CC2)C1 | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)C1 | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3CC34CCCCC4)CC2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]1&CC12CCCCC2",
"old_substring": "[C@H]19C[C@H]1C"
} |
Can you make molecule CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@@H]3CCCS[C@H]3C)CC2)C1 | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@H]3C[C@H]3C)CC2)C1 | CC(C)CN1CCO[C@H](CNC(=O)N2CCN(C(=O)[C@@H]3CCCS[C@H]3C)CC2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCS[C@H]1C",
"old_substring": "[C@H]19C[C@H]1C"
} |
Can you make molecule Cc1c[nH]c(CN(C)CCc2c(F)cccc2Cl)[nH+]1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1c[nH]c(CN(C)CCCCc2c(F)cccc2Cl)[nH+]1 | Cc1c[nH]c(CN(C)CCc2c(F)cccc2Cl)[nH+]1 | Cc1c[nH]c(CN(C)CCCCc2c(F)cccc2Cl)[nH+]1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C4C6"
} |
Can you make molecule Cc1c[nH]c(CN(C)CCc2c(F)cccc2Cl)[nH+]1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1c[nH]c(CN(C)CCCCCc2c(F)cccc2Cl)[nH+]1 | Cc1c[nH]c(CN(C)CCc2c(F)cccc2Cl)[nH+]1 | Cc1c[nH]c(CN(C)CCCCCc2c(F)cccc2Cl)[nH+]1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C4C6"
} |
Can you make molecule Cc1c[nH]c(CN(C)CCc2c(F)cccc2Cl)[nH+]1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1c[nH]c(CN(C)C2CC(c3c(F)cccc3Cl)C2)[nH+]1 | Cc1c[nH]c(CN(C)CCc2c(F)cccc2Cl)[nH+]1 | Cc1c[nH]c(CN(C)C2CC(c3c(F)cccc3Cl)C2)[nH+]1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C4C6"
} |
Can you make molecule Cc1c[nH]c(CN(C)CCc2c(F)cccc2Cl)[nH+]1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1c[nH]c(CN(C)[C@@H](C)CCc2c(F)cccc2Cl)[nH+]1 | Cc1c[nH]c(CN(C)CCc2c(F)cccc2Cl)[nH+]1 | Cc1c[nH]c(CN(C)[C@@H](C)CCc2c(F)cccc2Cl)[nH+]1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C4C6"
} |
Can you make molecule Cc1c[nH]c(CN(C)CCc2c(F)cccc2Cl)[nH+]1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1c[nH]c(CN(C)C2CCC(c3c(F)cccc3Cl)CC2)[nH+]1 | Cc1c[nH]c(CN(C)CCc2c(F)cccc2Cl)[nH+]1 | Cc1c[nH]c(CN(C)C2CCC(c3c(F)cccc3Cl)CC2)[nH+]1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C4C6"
} |
Can you make molecule C#CCCCC[NH2+][C@@H](C)c1sc(-c2ccccc2)nc1C less soluble in water? The output molecule should be similar to the input molecule. | C#CCCCC[NH2+][C@H](CCl)CCCc1sc(-c2ccccc2)nc1C | C#CCCCC[NH2+][C@@H](C)c1sc(-c2ccccc2)nc1C | C#CCCCC[NH2+][C@H](CCl)CCCc1sc(-c2ccccc2)nc1C | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]45C"
} |
Can you make molecule C#CCCCC[NH2+][C@@H](C)c1sc(-c2ccccc2)nc1C less soluble in water? The output molecule should be similar to the input molecule. | C#CCCCC[NH2+][C@@H]1N=NC=C1CCc1sc(-c2ccccc2)nc1C | C#CCCCC[NH2+][C@@H](C)c1sc(-c2ccccc2)nc1C | C#CCCCC[NH2+][C@@H]1N=NC=C1CCc1sc(-c2ccccc2)nc1C | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]1&N=NC=C1CC&",
"old_substring": "[C@@H]45C"
} |
Can you make molecule C#CCCCC[NH2+][C@@H](C)c1sc(-c2ccccc2)nc1C less soluble in water? The output molecule should be similar to the input molecule. | C#CCCCC[NH2+][C@@H]1CC[C@@H](c2sc(-c3ccccc3)nc2C)C1 | C#CCCCC[NH2+][C@@H](C)c1sc(-c2ccccc2)nc1C | C#CCCCC[NH2+][C@@H]1CC[C@@H](c2sc(-c3ccccc3)nc2C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]45C"
} |
Can you make molecule C#CCCCC[NH2+][C@@H](C)c1sc(-c2ccccc2)nc1C less soluble in water? The output molecule should be similar to the input molecule. | C#CCCCC[NH2+][C@H](C)C(C)(C)Cc1sc(-c2ccccc2)nc1C | C#CCCCC[NH2+][C@@H](C)c1sc(-c2ccccc2)nc1C | C#CCCCC[NH2+][C@H](C)C(C)(C)Cc1sc(-c2ccccc2)nc1C | 102 | {
"fragment_index": 0,
"new_substring": "[C@@H]&(C)C(C)(C)C&",
"old_substring": "[C@@H]45C"
} |
Can you make molecule C#CCCCC[NH2+][C@@H](C)c1sc(-c2ccccc2)nc1C less soluble in water? The output molecule should be similar to the input molecule. | C#CCCCC[NH2+][C@@H](CC)CCc1sc(-c2ccccc2)nc1C | C#CCCCC[NH2+][C@@H](C)c1sc(-c2ccccc2)nc1C | C#CCCCC[NH2+][C@@H](CC)CCc1sc(-c2ccccc2)nc1C | 102 | {
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@@H]45C"
} |
Can you make molecule Cc1cn(-c2ccccc2Cl)nc1NC(=O)N1CCC[C@H]([C@@H](C)O)C1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cn(-c2ccccc2Cl)nc1NC(=O)CC(C)(C)N1CCC[C@H]([C@@H](C)O)C1 | Cc1cn(-c2ccccc2Cl)nc1NC(=O)N1CCC[C@H]([C@@H](C)O)C1 | Cc1cn(-c2ccccc2Cl)nc1NC(=O)CC(C)(C)N1CCC[C@H]([C@@H](C)O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
} |
Can you make molecule Cc1cn(-c2ccccc2Cl)nc1NC(=O)N1CCC[C@H]([C@@H](C)O)C1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cn(-c2ccccc2Cl)nc1NC(=O)CCC(C)(C)N1CCC[C@H]([C@@H](C)O)C1 | Cc1cn(-c2ccccc2Cl)nc1NC(=O)N1CCC[C@H]([C@@H](C)O)C1 | Cc1cn(-c2ccccc2Cl)nc1NC(=O)CCC(C)(C)N1CCC[C@H]([C@@H](C)O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
} |
Can you make molecule Cc1cn(-c2ccccc2Cl)nc1NC(=O)N1CCC[C@H]([C@@H](C)O)C1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cn(-c2ccccc2Cl)nc1NC(=O)C[C@@H](Br)N1CCC[C@H]([C@@H](C)O)C1 | Cc1cn(-c2ccccc2Cl)nc1NC(=O)N1CCC[C@H]([C@@H](C)O)C1 | Cc1cn(-c2ccccc2Cl)nc1NC(=O)C[C@@H](Br)N1CCC[C@H]([C@@H](C)O)C1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
} |
Can you make molecule Cc1cn(-c2ccccc2Cl)nc1NC(=O)N1CCC[C@H]([C@@H](C)O)C1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cn(-c2ccccc2Cl)nc1Nc1cc(C)n(N2CCC[C@H]([C@@H](C)O)C2)c(=O)c1 | Cc1cn(-c2ccccc2Cl)nc1NC(=O)N1CCC[C@H]([C@@H](C)O)C1 | Cc1cn(-c2ccccc2Cl)nc1Nc1cc(C)n(N2CCC[C@H]([C@@H](C)O)C2)c(=O)c1 | 102 | {
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C34=O"
} |
Can you make molecule Cc1cn(-c2ccccc2Cl)nc1NC(=O)N1CCC[C@H]([C@@H](C)O)C1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cn(-c2ccccc2Cl)nc1Nc1c(C)n(N2CCC[C@H]([C@@H](C)O)C2)ccc1=O | Cc1cn(-c2ccccc2Cl)nc1NC(=O)N1CCC[C@H]([C@@H](C)O)C1 | Cc1cn(-c2ccccc2Cl)nc1Nc1c(C)n(N2CCC[C@H]([C@@H](C)O)C2)ccc1=O | 102 | {
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C34=O"
} |
Can you make molecule Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1Cl | Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1 | Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "C=&c1cccc(Cl)c1Cl",
"old_substring": "C=4c1cccc(Cl)c1"
} |
Can you make molecule Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule. | CCC(=C1CCn2c1nc1sc(C)c(C)c1c2=O)c1cccc(Cl)c1 | Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1 | CCC(=C1CCn2c1nc1sc(C)c(C)c1c2=O)c1cccc(Cl)c1 | 102 | {
"fragment_index": 0,
"new_substring": "CCC=&c1cccc(Cl)c1",
"old_substring": "C=4c1cccc(Cl)c1"
} |
Can you make molecule Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule. | CC(=C1CCn2c1nc1sc(C)c(C)c1c2=O)c1cccc(Cl)c1Cl | Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1 | CC(=C1CCn2c1nc1sc(C)c(C)c1c2=O)c1cccc(Cl)c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "CC=&c1cccc(Cl)c1Cl",
"old_substring": "C=4c1cccc(Cl)c1"
} |
Can you make molecule Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1ccc(Cl)cc1Cl | Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1 | Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1ccc(Cl)cc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "C=&c1ccc(Cl)cc1Cl",
"old_substring": "C=4c1cccc(Cl)c1"
} |
Can you make molecule Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1c(Cl)cccc1Cl | Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1cccc(Cl)c1 | Cc1sc2nc3n(c(=O)c2c1C)CCC3=Cc1c(Cl)cccc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "Clc1cccc(Cl)c1C=&",
"old_substring": "C=4c1cccc(Cl)c1"
} |
Can you make molecule Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1I | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1 | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1I | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17ccc5cc1"
} |
Can you make molecule Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1cc(NS(C)(=O)=O)ccc1Br | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1 | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1cc(NS(C)(=O)=O)ccc1Br | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17ccc5cc1"
} |
Can you make molecule Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1Cl | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1 | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17ccc5cc1"
} |
Can you make molecule Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1cccc(NS(C)(=O)=O)c1Br | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1 | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1cccc(NS(C)(=O)=O)c1Br | 102 | {
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17ccc5cc1"
} |
Can you make molecule Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1 less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1cccc(NS(C)(=O)=O)c1Cl | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1ccc(NS(C)(=O)=O)cc1 | Cc1cc(=O)oc(C)c1C(=O)O[C@H](C)C(=O)c1cccc(NS(C)(=O)=O)c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17ccc5cc1"
} |
Can you make molecule COC(=O)[C@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(C)C less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(=O)C1OCc2ccccc2CO1 | COC(=O)[C@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(C)C | CC(C)[C@@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(=O)C1OCc2ccccc2CO1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&OCc2ccccc2CO1",
"old_substring": "CO2"
} |
Can you make molecule COC(=O)[C@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(C)C less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(=O)C1(O)Cc2ccccc2C1 | COC(=O)[C@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(C)C | CC(C)[C@@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(=O)C1(O)Cc2ccccc2C1 | 102 | {
"fragment_index": 0,
"new_substring": "C1&(O)Cc2ccccc2C1",
"old_substring": "CO2"
} |
Can you make molecule COC(=O)[C@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(C)C less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(=O)C1=CC2=NN2C[C@@H](C)CO1 | COC(=O)[C@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(C)C | CC(C)[C@@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(=O)C1=CC2=NN2C[C@@H](C)CO1 | 102 | {
"fragment_index": 0,
"new_substring": "C[C@H]1COc2cc&nn2C1",
"old_substring": "CO2"
} |
Can you make molecule COC(=O)[C@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(C)C less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(=O)N1CCOC12CCCCC2 | COC(=O)[C@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(C)C | CC(C)[C@@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(=O)N1CCOC12CCCCC2 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCOC12CCCCC2",
"old_substring": "CO2"
} |
Can you make molecule COC(=O)[C@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(C)C less soluble in water? The output molecule should be similar to the input molecule. | CC(C)[C@@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(=O)N1CCOC2(CCC2)C1 | COC(=O)[C@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(C)C | CC(C)[C@@H](NC(=O)COc1cc(Cl)c(Cl)cc1Cl)C(=O)N1CCOC2(CCC2)C1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCOC2(CCC2)C1",
"old_substring": "CO2"
} |
Can you make molecule C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1ccc(Cl)s1 | C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1cccs1 | C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1ccc(Cl)s1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)s1",
"old_substring": "c14cccs1"
} |
Can you make molecule C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1ccc(Br)s1 | C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1cccs1 | C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1ccc(Br)s1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Br)s1",
"old_substring": "c14cccs1"
} |
Can you make molecule C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1sccc1Br | C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1cccs1 | C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1sccc1Br | 102 | {
"fragment_index": 0,
"new_substring": "c1&sccc1Br",
"old_substring": "c14cccs1"
} |
Can you make molecule C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@]1(O)CNc2cc1cnc(C(=O)CCc1cccc([N+](=O)[O-])c1)ccs2 | C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1cccs1 | C[C@@]1(O)CNc2cc1cnc(C(=O)CCc1cccc([N+](=O)[O-])c1)ccs2 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cnc2ccsc2c1",
"old_substring": "c14cccs1"
} |
Can you make molecule C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@@]1(O)CNc2cnsc(C(=O)CCc3cccc([N+](=O)[O-])c3)ccc1c2 | C[C@@](O)(CNC(=O)CCc1cccc([N+](=O)[O-])c1)c1cccs1 | C[C@@]1(O)CNc2cnsc(C(=O)CCc3cccc([N+](=O)[O-])c3)ccc1c2 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc2sncc2c1",
"old_substring": "c14cccs1"
} |
Can you make molecule CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CCCSN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 | CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 | CCCSN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "S&N1CCN&CC1",
"old_substring": "N13CCN4CC1"
} |
Can you make molecule CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CCCN1CCCN(S(=O)(=O)c2cc(C)cc(N)c2C)C1=O | CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 | CCCN1CCCN(S(=O)(=O)c2cc(C)cc(N)c2C)C1=O | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCCN&C1=O",
"old_substring": "N13CCN4CC1"
} |
Can you make molecule CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CCCN1CCN=C1SS(=O)(=O)c1cc(C)cc(N)c1C | CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 | CCCN1CCN=C1SS(=O)(=O)c1cc(C)cc(N)c1C | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N13CCN4CC1"
} |
Can you make molecule CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)C(C)(C)C1 | CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 | CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)C(C)(C)C1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCN&C(C)(C)C1",
"old_substring": "N13CCN4CC1"
} |
Can you make molecule CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 less soluble in water? The output molecule should be similar to the input molecule. | CCCN1CCC(C#N)(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 | CCCN1CCN(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 | CCCN1CCC(C#N)(S(=O)(=O)c2cc(C)cc(N)c2C)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCC&(C#N)CC1",
"old_substring": "N13CCN4CC1"
} |
Can you make molecule O=C(NCc1cc2ccccc2o1)Nc1cccnc1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(NCSCc1cc2ccccc2o1)Nc1cccnc1 | O=C(NCc1cc2ccccc2o1)Nc1cccnc1 | O=C(NCSCc1cc2ccccc2o1)Nc1cccnc1 | 102 | {
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N35"
} |
Can you make molecule O=C(NCc1cc2ccccc2o1)Nc1cccnc1 less soluble in water? The output molecule should be similar to the input molecule. | N=C(NC(=O)Nc1cccnc1)SCc1cc2ccccc2o1 | O=C(NCc1cc2ccccc2o1)Nc1cccnc1 | N=C(NC(=O)Nc1cccnc1)SCc1cc2ccccc2o1 | 102 | {
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N35"
} |
Can you make molecule O=C(NCc1cc2ccccc2o1)Nc1cccnc1 less soluble in water? The output molecule should be similar to the input molecule. | CN(C(=O)Nc1cccnc1)C(=S)SCc1cc2ccccc2o1 | O=C(NCc1cc2ccccc2o1)Nc1cccnc1 | CN(C(=O)Nc1cccnc1)C(=S)SCc1cc2ccccc2o1 | 102 | {
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N35"
} |
Can you make molecule O=C(NCc1cc2ccccc2o1)Nc1cccnc1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(Nc1cccnc1)N1CCN=C1SCc1cc2ccccc2o1 | O=C(NCc1cc2ccccc2o1)Nc1cccnc1 | O=C(Nc1cccnc1)N1CCN=C1SCc1cc2ccccc2o1 | 102 | {
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N35"
} |
Can you make molecule O=C(NCc1cc2ccccc2o1)Nc1cccnc1 less soluble in water? The output molecule should be similar to the input molecule. | O=C(CN1CCC(Cc2cc3ccccc3o2)CC1)Nc1cccnc1 | O=C(NCc1cc2ccccc2o1)Nc1cccnc1 | O=C(CN1CCC(Cc2cc3ccccc3o2)CC1)Nc1cccnc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N35"
} |
Can you make molecule C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)S(=O)(=O)N1CCN(C(=O)NC[C@@H](C)N2CCOCC2)CC1 | C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1 | CC(C)S(=O)(=O)N1CCN(C(=O)NC[C@@H](C)N2CCOCC2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "CC(C)S&(=O)=O",
"old_substring": "S6(C)(=O)=O"
} |
Can you make molecule C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)CS(=O)(=O)N1CCN(C(=O)NC[C@@H](C)N2CCOCC2)CC1 | C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1 | CC(C)CS(=O)(=O)N1CCN(C(=O)NC[C@@H](C)N2CCOCC2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "CC(C)CS&(=O)=O",
"old_substring": "S6(C)(=O)=O"
} |
Can you make molecule C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](CNC(=O)N1CCN(CCCCS(C)(=O)=O)CC1)N1CCOCC1 | C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1 | C[C@H](CNC(=O)N1CCN(CCCCS(C)(=O)=O)CC1)N1CCOCC1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCS(C)(=O)=O",
"old_substring": "S6(C)(=O)=O"
} |
Can you make molecule C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule. | C[C@H](CNC(=O)N1CCN(C(=O)N=S(C)(C)=O)CC1)N1CCOCC1 | C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1 | C[C@H](CNC(=O)N1CCN(C(=O)N=S(C)(C)=O)CC1)N1CCOCC1 | 102 | {
"fragment_index": 0,
"new_substring": "CS(C)(=O)=NC&=O",
"old_substring": "S6(C)(=O)=O"
} |
Can you make molecule C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule. | CC(C)S(=O)(=O)CN1CCN(C(=O)NC[C@@H](C)N2CCOCC2)CC1 | C[C@H](CNC(=O)N1CCN(S(C)(=O)=O)CC1)N1CCOCC1 | CC(C)S(=O)(=O)CN1CCN(C(=O)NC[C@@H](C)N2CCOCC2)CC1 | 102 | {
"fragment_index": 0,
"new_substring": "CC(C)S(=O)(=O)C&",
"old_substring": "S6(C)(=O)=O"
} |
Can you make molecule N#Cc1c(F)cccc1Nc1nc(Cl)ncc1Br less soluble in water? The output molecule should be similar to the input molecule. | N#Cc1c(F)cccc1Nc1cc(Cl)nc(Br)c1 | N#Cc1c(F)cccc1Nc1nc(Cl)ncc1Br | N#Cc1c(F)cccc1Nc1cc(Cl)nc(Br)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc(Cl)nc(Br)c1",
"old_substring": "c12nc(Cl)ncc1Br"
} |
Can you make molecule N#Cc1c(F)cccc1Nc1nc(Cl)ncc1Br less soluble in water? The output molecule should be similar to the input molecule. | N#Cc1c(F)cccc1Nc1nsc(Cl)c1Cl | N#Cc1c(F)cccc1Nc1nc(Cl)ncc1Br | N#Cc1c(F)cccc1Nc1nsc(Cl)c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&nsc(Cl)c1Cl",
"old_substring": "c12nc(Cl)ncc1Br"
} |
Can you make molecule N#Cc1c(F)cccc1Nc1nc(Cl)ncc1Br less soluble in water? The output molecule should be similar to the input molecule. | Cc1cc(C)c(Nc2cccc(F)c2C#N)c(Br)c1 | N#Cc1c(F)cccc1Nc1nc(Cl)ncc1Br | Cc1cc(C)c(Nc2cccc(F)c2C#N)c(Br)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&c(C)cc(C)cc1Br",
"old_substring": "c12nc(Cl)ncc1Br"
} |
Can you make molecule N#Cc1c(F)cccc1Nc1nc(Cl)ncc1Br less soluble in water? The output molecule should be similar to the input molecule. | Cc1ncc(Nc2cccc(F)c2C#N)c(Br)c1Cl | N#Cc1c(F)cccc1Nc1nc(Cl)ncc1Br | Cc1ncc(Nc2cccc(F)c2C#N)c(Br)c1Cl | 102 | {
"fragment_index": 0,
"new_substring": "c1&cnc(C)c(Cl)c1Br",
"old_substring": "c12nc(Cl)ncc1Br"
} |
Can you make molecule N#Cc1c(F)cccc1Nc1nc(Cl)ncc1Br less soluble in water? The output molecule should be similar to the input molecule. | N#Cc1c(F)cccc1Nc1ccc(Cl)cc1Br | N#Cc1c(F)cccc1Nc1nc(Cl)ncc1Br | N#Cc1c(F)cccc1Nc1ccc(Cl)cc1Br | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1Br",
"old_substring": "c12nc(Cl)ncc1Br"
} |
Can you make molecule O=S(=O)(NCC#CCOc1cccc(C(F)(F)F)c1)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule. | O=S(=O)(NCC#CCOc1cccc(SC(F)(F)F)c1)c1ccc(F)cc1 | O=S(=O)(NCC#CCOc1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | O=S(=O)(NCC#CCOc1cccc(SC(F)(F)F)c1)c1ccc(F)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C6(F)(F)F"
} |
Can you make molecule O=S(=O)(NCC#CCOc1cccc(C(F)(F)F)c1)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule. | O=S(=O)(NCC#CCOc1cccc(CCCC(F)(F)F)c1)c1ccc(F)cc1 | O=S(=O)(NCC#CCOc1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | O=S(=O)(NCC#CCOc1cccc(CCCC(F)(F)F)c1)c1ccc(F)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C6(F)(F)F"
} |
Can you make molecule O=S(=O)(NCC#CCOc1cccc(C(F)(F)F)c1)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule. | O=S(=O)(NCC#CCOc1cccc(CCCCC(F)(F)F)c1)c1ccc(F)cc1 | O=S(=O)(NCC#CCOc1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | O=S(=O)(NCC#CCOc1cccc(CCCCC(F)(F)F)c1)c1ccc(F)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C6(F)(F)F"
} |
Can you make molecule O=S(=O)(NCC#CCOc1cccc(C(F)(F)F)c1)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule. | O=S(=O)(NCC#CCOc1cccc(C(F)(F)C(F)(F)F)c1)c1ccc(F)cc1 | O=S(=O)(NCC#CCOc1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | O=S(=O)(NCC#CCOc1cccc(C(F)(F)C(F)(F)F)c1)c1ccc(F)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&(F)(F)C(F)(F)F",
"old_substring": "C6(F)(F)F"
} |
Can you make molecule O=S(=O)(NCC#CCOc1cccc(C(F)(F)F)c1)c1ccc(F)cc1 less soluble in water? The output molecule should be similar to the input molecule. | O=S(=O)(NCC#CCOc1cccc(CC(F)(F)C(F)(F)F)c1)c1ccc(F)cc1 | O=S(=O)(NCC#CCOc1cccc(C(F)(F)F)c1)c1ccc(F)cc1 | O=S(=O)(NCC#CCOc1cccc(CC(F)(F)C(F)(F)F)c1)c1ccc(F)cc1 | 102 | {
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)(F)F",
"old_substring": "C6(F)(F)F"
} |
Can you make molecule COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2I)c1 | COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2)c1 | COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2I)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17ccc8cc1"
} |
Can you make molecule COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc(Oc2cc(NC(=O)c3ccncc3Cl)ccc2Br)c1 | COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2)c1 | COc1cccc(Oc2cc(NC(=O)c3ccncc3Cl)ccc2Br)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17ccc8cc1"
} |
Can you make molecule COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2Cl)c1 | COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2)c1 | COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2Cl)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17ccc8cc1"
} |
Can you make molecule COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc(Oc2cccc(NC(=O)c3ccncc3Cl)c2Br)c1 | COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2)c1 | COc1cccc(Oc2cccc(NC(=O)c3ccncc3Cl)c2Br)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17ccc8cc1"
} |
Can you make molecule COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule. | COc1cccc(Oc2cccc(NC(=O)c3ccncc3Cl)c2Cl)c1 | COc1cccc(Oc2ccc(NC(=O)c3ccncc3Cl)cc2)c1 | COc1cccc(Oc2cccc(NC(=O)c3ccncc3Cl)c2Cl)c1 | 102 | {
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17ccc8cc1"
} |
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