prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule O[C@H](c1nccs1)c1ccccc1N1CCN(Cc2ccccc2F)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@H](c1ccsc1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
|
O[C@H](c1nccs1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
|
O[C@H](c1ccsc1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccsc1",
"old_substring": "c15nccs1"
}
|
Can you make molecule O[C@H](c1nccs1)c1ccccc1N1CCN(Cc2ccccc2F)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@H](c1cnc(Br)s1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
|
O[C@H](c1nccs1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
|
O[C@H](c1cnc(Br)s1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1ncc&s1",
"old_substring": "c15nccs1"
}
|
Can you make molecule O[C@H](c1nccs1)c1ccccc1N1CCN(Cc2ccccc2F)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@H](c1ncc(Cl)s1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
|
O[C@H](c1nccs1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
|
O[C@H](c1ncc(Cl)s1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc(Cl)s1",
"old_substring": "c15nccs1"
}
|
Can you make molecule O[C@H](c1nccs1)c1ccccc1N1CCN(Cc2ccccc2F)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@H](c1ncc(Br)s1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
|
O[C@H](c1nccs1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
|
O[C@H](c1ncc(Br)s1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc(Br)s1",
"old_substring": "c15nccs1"
}
|
Can you make molecule O[C@H](c1nccs1)c1ccccc1N1CCN(Cc2ccccc2F)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@@H](c1ccccc1N1CCN(Cc2ccccc2F)CC1)c1scnc1Cl
|
O[C@H](c1nccs1)c1ccccc1N1CCN(Cc2ccccc2F)CC1
|
O[C@@H](c1ccccc1N1CCN(Cc2ccccc2F)CC1)c1scnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&scnc1Cl",
"old_substring": "c15nccs1"
}
|
Can you make molecule CC(C)COC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)COSC(=O)Cc1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
|
CC(C)COC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
|
CC(C)COSC(=O)Cc1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)COC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)COC(=O)CCCC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
|
CC(C)COC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
|
CC(C)COC(=O)CCCC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)COC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)COC(=O)CC(C)(C)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
|
CC(C)COC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
|
CC(C)COC(=O)CC(C)(C)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)COC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)COC(=O)CCC(C)(C)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
|
CC(C)COC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
|
CC(C)COC(=O)CCC(C)(C)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule CC(C)COC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)COSC(=O)[C@@H](C)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
|
CC(C)COC(=O)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
|
CC(C)COSC(=O)[C@@H](C)c1c(N)n(Cc2ccc3c(c2)OCO3)c2nc3ccccc3nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1c(COC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(CCCCOC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
|
Cc1c(COC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
|
Cc1c(CCCCOC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C46"
}
|
Can you make molecule Cc1c(COC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(CCCCCOC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
|
Cc1c(COC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
|
Cc1c(CCCCCOC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C46"
}
|
Can you make molecule Cc1c(COC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C2CC(OC(=O)c3cc[nH]n3)C2)cccc1[N+](=O)[O-]
|
Cc1c(COC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
|
Cc1c(C2CC(OC(=O)c3cc[nH]n3)C2)cccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C46"
}
|
Can you make molecule Cc1c(COC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(SC(=S)OOC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
|
Cc1c(COC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
|
Cc1c(SC(=S)OOC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C46"
}
|
Can you make molecule Cc1c(COC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(NC(=S)SOC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
|
Cc1c(COC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
|
Cc1c(NC(=S)SOC(=O)c2cc[nH]n2)cccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C46"
}
|
Can you make molecule COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)ccc1OCC(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)c(OCC(N)=O)cc1I
|
COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)ccc1OCC(N)=O
|
COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)c(OCC(N)=O)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1I",
"old_substring": "c15cc9ccc16"
}
|
Can you make molecule COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)ccc1OCC(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)c(OCC(N)=O)cc1Cl
|
COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)ccc1OCC(N)=O
|
COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)c(OCC(N)=O)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1Cl",
"old_substring": "c15cc9ccc16"
}
|
Can you make molecule COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)ccc1OCC(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)cc(I)c1OCC(N)=O
|
COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)ccc1OCC(N)=O
|
COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)cc(I)c1OCC(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&cc(I)c1&",
"old_substring": "c15cc9ccc16"
}
|
Can you make molecule COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)ccc1OCC(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)c(OCC(N)=O)c(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)c1
|
COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)ccc1OCC(N)=O
|
COc1cc(Br)c(OCC(N)=O)c(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&c(Br)c1",
"old_substring": "c15cc9ccc16"
}
|
Can you make molecule COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)ccc1OCC(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)c(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)cc1OCC(N)=O
|
COc1cc(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)ccc1OCC(N)=O
|
COc1cc(Br)c(C[NH2+][C@@H]2C[C@H]3CC[C@]2(C)C3(C)C)cc1OCC(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)c&cc1&",
"old_substring": "c15cc9ccc16"
}
|
Can you make molecule Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1I
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1I",
"old_substring": "c18ccc(Cl)cc1"
}
|
Can you make molecule Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1Br
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1Br",
"old_substring": "c18ccc(Cl)cc1"
}
|
Can you make molecule Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)c(I)c1
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)c(I)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(I)c1",
"old_substring": "c18ccc(Cl)cc1"
}
|
Can you make molecule Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1cc(Cl)ccc1Cl
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1cc(Cl)ccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1ccc(Cl)c&c1",
"old_substring": "c18ccc(Cl)cc1"
}
|
Can you make molecule Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)c(Cl)c1
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)cc1
|
Cn1c(SCC(=O)N2CCN(S(=O)(=O)c3ccccc3)CC2)nnc1-c1ccc(Cl)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Cl)c1",
"old_substring": "c18ccc(Cl)cc1"
}
|
Can you make molecule OC[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(F)[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
|
OC[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
|
O=C(F)[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&F",
"old_substring": "OC4"
}
|
Can you make molecule OC[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
ClCO[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
|
OC[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
|
ClCO[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "O&CCl",
"old_substring": "OC4"
}
|
Can you make molecule OC[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cl)[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
|
OC[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
|
O=C(Cl)[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&Cl",
"old_substring": "OC4"
}
|
Can you make molecule OC[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CF)[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
|
OC[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
|
O=C(CF)[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&CF",
"old_substring": "OC4"
}
|
Can you make molecule OC[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCl)[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
|
OC[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
|
O=C(CCCl)[C@H]1C[NH+](Cc2ccccc2)CCC12OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&CCCl",
"old_substring": "OC4"
}
|
Can you make molecule COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1
|
COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1
|
COCc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO2"
}
|
Can you make molecule COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=[N+]([O-])c1ccc(C2OCc3ccccc3CO2)c(S(=O)(=O)NC2CCCCCCC2)c1
|
COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1
|
O=[N+]([O-])c1ccc(C2OCc3ccccc3CO2)c(S(=O)(=O)NC2CCCCCCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&OCc2ccccc2CO1",
"old_substring": "CO2"
}
|
Can you make molecule COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=[N+]([O-])c1ccc(C2(O)Cc3ccccc3C2)c(S(=O)(=O)NC2CCCCCCC2)c1
|
COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1
|
O=[N+]([O-])c1ccc(C2(O)Cc3ccccc3C2)c(S(=O)(=O)NC2CCCCCCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(O)Cc2ccccc2C1",
"old_substring": "CO2"
}
|
Can you make molecule COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1COC(c2ccc([N+](=O)[O-])cc2S(=O)(=O)NC2CCCCCCC2)=CC2=NN2C1
|
COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1
|
C[C@H]1COC(c2ccc([N+](=O)[O-])cc2S(=O)(=O)NC2CCCCCCC2)=CC2=NN2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1COc2cc&nn2C1",
"old_substring": "CO2"
}
|
Can you make molecule COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=[N+]([O-])c1ccc(N2CCOc3ccccc32)c(S(=O)(=O)NC2CCCCCCC2)c1
|
COc1ccc([N+](=O)[O-])cc1S(=O)(=O)NC1CCCCCCC1
|
O=[N+]([O-])c1ccc(N2CCOc3ccccc32)c(S(=O)(=O)NC2CCCCCCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccccc21",
"old_substring": "CO2"
}
|
Can you make molecule C[C@@H](Nc1ccc(OC(F)F)cn1)c1ccc(NC(=O)C2CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(C)(C)c1ccc(NC(=O)C2CC2)cc1)Nc1ccc(OC(F)F)cn1
|
C[C@@H](Nc1ccc(OC(F)F)cn1)c1ccc(NC(=O)C2CC2)cc1
|
C[C@H](CC(C)(C)c1ccc(NC(=O)C2CC2)cc1)Nc1ccc(OC(F)F)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@@H]59"
}
|
Can you make molecule C[C@@H](Nc1ccc(OC(F)F)cn1)c1ccc(NC(=O)C2CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCNc1ccc(OC(F)F)cn1)CC(=O)c1ccc(NC(=O)C2CC2)cc1
|
C[C@@H](Nc1ccc(OC(F)F)cn1)c1ccc(NC(=O)C2CC2)cc1
|
C[C@@H](CCNc1ccc(OC(F)F)cn1)CC(=O)c1ccc(NC(=O)C2CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@@H]59"
}
|
Can you make molecule C[C@@H](Nc1ccc(OC(F)F)cn1)c1ccc(NC(=O)C2CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc([C@@H](Cl)CCNc2ccc(OC(F)F)cn2)cc1)C1CC1
|
C[C@@H](Nc1ccc(OC(F)F)cn1)c1ccc(NC(=O)C2CC2)cc1
|
O=C(Nc1ccc([C@@H](Cl)CCNc2ccc(OC(F)F)cn2)cc1)C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C[C@@H]&Cl",
"old_substring": "C[C@@H]59"
}
|
Can you make molecule C[C@@H](Nc1ccc(OC(F)F)cn1)c1ccc(NC(=O)C2CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H](CC(=O)c1ccc(NC(=O)C2CC2)cc1)Nc1ccc(OC(F)F)cn1
|
C[C@@H](Nc1ccc(OC(F)F)cn1)c1ccc(NC(=O)C2CC2)cc1
|
CCC[C@H](CC(=O)c1ccc(NC(=O)C2CC2)cc1)Nc1ccc(OC(F)F)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@@H]&CC&=O",
"old_substring": "C[C@@H]59"
}
|
Can you make molecule C[C@@H](Nc1ccc(OC(F)F)cn1)c1ccc(NC(=O)C2CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](CCc1ccc(NC(=O)C2CC2)cc1)Nc1ccc(OC(F)F)cn1
|
C[C@@H](Nc1ccc(OC(F)F)cn1)c1ccc(NC(=O)C2CC2)cc1
|
CC(C)[C@H](CCc1ccc(NC(=O)C2CC2)cc1)Nc1ccc(OC(F)F)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)[C@@H]&CC&",
"old_substring": "C[C@@H]59"
}
|
Can you make molecule CCOC(=O)c1c(C)csc1NC(=O)N1CCC[C@@H](OC)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1c(C)csc1NC(=O)CC(C)(C)N1CCC[C@@H](OC)C1
|
CCOC(=O)c1c(C)csc1NC(=O)N1CCC[C@@H](OC)C1
|
CCOC(=O)c1c(C)csc1NC(=O)CC(C)(C)N1CCC[C@@H](OC)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CCOC(=O)c1c(C)csc1NC(=O)N1CCC[C@@H](OC)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1c(C)csc1NC(=O)CCC(C)(C)N1CCC[C@@H](OC)C1
|
CCOC(=O)c1c(C)csc1NC(=O)N1CCC[C@@H](OC)C1
|
CCOC(=O)c1c(C)csc1NC(=O)CCC(C)(C)N1CCC[C@@H](OC)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CCOC(=O)c1c(C)csc1NC(=O)N1CCC[C@@H](OC)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1c(C)csc1NC(=O)C[C@@H](Br)N1CCC[C@@H](OC)C1
|
CCOC(=O)c1c(C)csc1NC(=O)N1CCC[C@@H](OC)C1
|
CCOC(=O)c1c(C)csc1NC(=O)C[C@@H](Br)N1CCC[C@@H](OC)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule CCOC(=O)c1c(C)csc1NC(=O)N1CCC[C@@H](OC)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1c(C)csc1Nc1cc(C)n(N2CCC[C@@H](OC)C2)c(=O)c1
|
CCOC(=O)c1c(C)csc1NC(=O)N1CCC[C@@H](OC)C1
|
CCOC(=O)c1c(C)csc1Nc1cc(C)n(N2CCC[C@@H](OC)C2)c(=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C34=O"
}
|
Can you make molecule CCOC(=O)c1c(C)csc1NC(=O)N1CCC[C@@H](OC)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1c(C)csc1Nc1c(C)n(N2CCC[C@@H](OC)C2)ccc1=O
|
CCOC(=O)c1c(C)csc1NC(=O)N1CCC[C@@H](OC)C1
|
CCOC(=O)c1c(C)csc1Nc1c(C)n(N2CCC[C@@H](OC)C2)ccc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C34=O"
}
|
Can you make molecule C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1C)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1Br)c1ccncc1
|
C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1C)c1ccncc1
|
C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1Br)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)cc1Br",
"old_substring": "c13ccc(Br)cc1C"
}
|
Can you make molecule C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1C)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\NC(=O)C(=O)Nc1ccc(Br)c(Cl)c1F)c1ccncc1
|
C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1C)c1ccncc1
|
C/C(=N\NC(=O)C(=O)Nc1ccc(Br)c(Cl)c1F)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)c(Cl)c1F",
"old_substring": "c13ccc(Br)cc1C"
}
|
Can you make molecule C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1C)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\NC(=O)C(=O)Nc1cc(Br)c(F)cc1Cl)c1ccncc1
|
C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1C)c1ccncc1
|
C/C(=N\NC(=O)C(=O)Nc1cc(Br)c(F)cc1Cl)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)c(F)cc1Cl",
"old_substring": "c13ccc(Br)cc1C"
}
|
Can you make molecule C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1C)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\NC(=O)C(=O)Nc1cc(Br)ccc1Br)c1ccncc1
|
C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1C)c1ccncc1
|
C/C(=N\NC(=O)C(=O)Nc1cc(Br)ccc1Br)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)ccc1Br",
"old_substring": "c13ccc(Br)cc1C"
}
|
Can you make molecule C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1C)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\NC(=O)C(=O)c1ccc(Br)cc2c(C)c(o1)N2)c1ccncc1
|
C/C(=N\NC(=O)C(=O)Nc1ccc(Br)cc1C)c1ccncc1
|
C/C(=N\NC(=O)C(=O)c1ccc(Br)cc2c(C)c(o1)N2)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&oc2ccc(Br)cc2c1C",
"old_substring": "c13ccc(Br)cc1C"
}
|
Can you make molecule CCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)/N=c1\sc2cc3c(cc2n1C1CC(C)C1)OCO3
|
CCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3
|
CC(=O)/N=c1\sc2cc3c(cc2n1C1CC(C)C1)OCO3
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1CC&C1",
"old_substring": "CCC4"
}
|
Can you make molecule CCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)/N=c1\sc2cc3c(cc2n1CCC(C)C)OCO3
|
CCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3
|
CC(=O)/N=c1\sc2cc3c(cc2n1CCC(C)C)OCO3
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC4"
}
|
Can you make molecule CCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)/N=c1\sc2cc3c(cc2n1CCCCBr)OCO3
|
CCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3
|
CC(=O)/N=c1\sc2cc3c(cc2n1CCCCBr)OCO3
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC4"
}
|
Can you make molecule CCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3
|
CCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3
|
C=CCCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC4"
}
|
Can you make molecule CCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)/N=c1\sc2cc3c(cc2n1CCCCCl)OCO3
|
CCCn1/c(=N/C(C)=O)sc2cc3c(cc21)OCO3
|
CC(=O)/N=c1\sc2cc3c(cc2n1CCCCCl)OCO3
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC4"
}
|
Can you make molecule Cc1ccc(N[C@H]2CCOC3(CCSCC3)C2)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Clc1cccc(C=N[C@H]2CCOC3(CCSCC3)C2)c1Cl
|
Cc1ccc(N[C@H]2CCOC3(CCSCC3)C2)c(Cl)c1
|
Clc1cccc(C=N[C@H]2CCOC3(CCSCC3)C2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1cccc(Cl)c1Cl",
"old_substring": "Cc1ccc4c(Cl)c1"
}
|
Can you make molecule Cc1ccc(N[C@H]2CCOC3(CCSCC3)C2)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Clc1cccc(Cl)c1C=N[C@H]1CCOC2(CCSCC2)C1
|
Cc1ccc(N[C@H]2CCOC3(CCSCC3)C2)c(Cl)c1
|
Clc1cccc(Cl)c1C=N[C@H]1CCOC2(CCSCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1cccc(Cl)c1C=&",
"old_substring": "Cc1ccc4c(Cl)c1"
}
|
Can you make molecule Cc1ccc(N[C@H]2CCOC3(CCSCC3)C2)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)cc(Cl)c1N[C@H]1CCOC2(CCSCC2)C1
|
Cc1ccc(N[C@H]2CCOC3(CCSCC3)C2)c(Cl)c1
|
Cc1cc(Cl)cc(Cl)c1N[C@H]1CCOC2(CCSCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(Cl)cc(Cl)c1&",
"old_substring": "Cc1ccc4c(Cl)c1"
}
|
Can you make molecule Cc1ccc(N[C@H]2CCOC3(CCSCC3)C2)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N[C@H]2CCOC3(CCSCC3)C2)c(Br)c(C)c1Cl
|
Cc1ccc(N[C@H]2CCOC3(CCSCC3)C2)c(Cl)c1
|
Cc1cc(N[C@H]2CCOC3(CCSCC3)C2)c(Br)c(C)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&c(Br)c(C)c1Cl",
"old_substring": "Cc1ccc4c(Cl)c1"
}
|
Can you make molecule Cc1ccc(N[C@H]2CCOC3(CCSCC3)C2)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(Br)cc(N[C@H]2CCOC3(CCSCC3)C2)c(C)c1C
|
Cc1ccc(N[C@H]2CCOC3(CCSCC3)C2)c(Cl)c1
|
Cc1c(Br)cc(N[C@H]2CCOC3(CCSCC3)C2)c(C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c(Br)cc&c(C)c1C",
"old_substring": "Cc1ccc4c(Cl)c1"
}
|
Can you make molecule Cc1ccc2cccc(Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2cccc(SCNc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1
|
Cc1ccc2cccc(Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1
|
Cc1ccc2cccc(SCNc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N68"
}
|
Can you make molecule Cc1ccc2cccc(Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2cccc(SC(=N)Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1
|
Cc1ccc2cccc(Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1
|
Cc1ccc2cccc(SC(=N)Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N68"
}
|
Can you make molecule Cc1ccc2cccc(Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2cccc(SC(=S)N(C)c3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1
|
Cc1ccc2cccc(Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1
|
Cc1ccc2cccc(SC(=S)N(C)c3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N68"
}
|
Can you make molecule Cc1ccc2cccc(Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2cccc(C3CCN(Cc4ncnc(Nc5ccc6c(c5)OCO6)c4[N+](=O)[O-])CC3)c2n1
|
Cc1ccc2cccc(Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1
|
Cc1ccc2cccc(C3CCN(Cc4ncnc(Nc5ccc6c(c5)OCO6)c4[N+](=O)[O-])CC3)c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N68"
}
|
Can you make molecule Cc1ccc2cccc(Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2cccc(-c3cccc(-c4ncnc(Nc5ccc6c(c5)OCO6)c4[N+](=O)[O-])c3N)c2n1
|
Cc1ccc2cccc(Nc3ncnc(Nc4ccc5c(c4)OCO5)c3[N+](=O)[O-])c2n1
|
Cc1ccc2cccc(-c3cccc(-c4ncnc(Nc5ccc6c(c5)OCO6)c4[N+](=O)[O-])c3N)c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&cccc1&",
"old_substring": "N68"
}
|
Can you make molecule CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1I)[NH+]1CCCCC1
|
CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1
|
CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1I)[NH+]1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CNC(=O)c1cc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)ccc1Br)[NH+]1CCCCC1
|
CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1
|
CC(C)(CNC(=O)c1cc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)ccc1Br)[NH+]1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1Cl)[NH+]1CCCCC1
|
CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1
|
CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1Cl)[NH+]1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CNC(=O)c1cccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)c1Br)[NH+]1CCCCC1
|
CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1
|
CC(C)(CNC(=O)c1cccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)c1Br)[NH+]1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CNC(=O)c1cccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)c1Cl)[NH+]1CCCCC1
|
CC(C)(CNC(=O)c1ccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)cc1)[NH+]1CCCCC1
|
CC(C)(CNC(=O)c1cccc([N-]S(=O)(=O)c2cc(Cl)sc2Cl)c1Cl)[NH+]1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c18ccc7cc1"
}
|
Can you make molecule CC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1
|
CC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1
|
C=CCC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@]1(C2(O)CCCCCC2)CCC[C@H](CCCCl)C1
|
CC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1
|
[NH3+]C[C@]1(C2(O)CCCCCC2)CCC[C@H](CCCCl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@]1(C2(O)CCCCCC2)CCC[C@H](CCCCS)C1
|
CC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1
|
[NH3+]C[C@]1(C2(O)CCCCCC2)CCC[C@H](CCCCS)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@]1(C2(O)CCCCCC2)CCC[C@H](CCCBr)C1
|
CC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1
|
[NH3+]C[C@]1(C2(O)CCCCCC2)CCC[C@H](CCCBr)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+]C[C@]1(C2(O)CCCCCC2)CCC[C@H](CCCCF)C1
|
CC[C@H]1CCC[C@](C[NH3+])(C2(O)CCCCCC2)C1
|
[NH3+]C[C@]1(C2(O)CCCCCC2)CCC[C@H](CCCCF)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCF",
"old_substring": "CC3"
}
|
Can you make molecule CCC(CC)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)SCNC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12
|
CCC(CC)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12
|
CCC(CC)SCNC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12
| 102
|
{
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N45"
}
|
Can you make molecule CCC(CC)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)C1CN(C(=O)[C@H](C)Sc2nnc3n(C)c(=O)c4ccccc4n23)C1
|
CCC(CC)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12
|
CCC(CC)C1CN(C(=O)[C@H](C)Sc2nnc3n(C)c(=O)c4ccccc4n23)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC&C1",
"old_substring": "N45"
}
|
Can you make molecule CCC(CC)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)SC(=N)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12
|
CCC(CC)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12
|
CCC(CC)SC(=N)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N45"
}
|
Can you make molecule CCC(CC)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)c1snc(C(=O)[C@H](C)Sc2nnc3n(C)c(=O)c4ccccc4n23)c1N
|
CCC(CC)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12
|
CCC(CC)c1snc(C(=O)[C@H](C)Sc2nnc3n(C)c(=O)c4ccccc4n23)c1N
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&nsc1&",
"old_substring": "N45"
}
|
Can you make molecule CCC(CC)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)SC(=S)N(C)C(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12
|
CCC(CC)NC(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12
|
CCC(CC)SC(=S)N(C)C(=O)[C@H](C)Sc1nnc2n(C)c(=O)c3ccccc3n12
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N45"
}
|
Can you make molecule Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCOC[C@H]1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCC[C@@H](C2CC2)C1
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCOC[C@H]1C1CC1
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCC[C@@H](C2CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC[C@@H]&C1",
"old_substring": "N14CCOC[C@H]17"
}
|
Can you make molecule Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCOC[C@H]1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCC[C@H](C2CC2)CC1
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCOC[C@H]1C1CC1
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCC[C@H](C2CC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC[C@H]&CC1",
"old_substring": "N14CCOC[C@H]17"
}
|
Can you make molecule Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCOC[C@H]1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCC[C@H](C2CC2)C1=O
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCOC[C@H]1C1CC1
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCC[C@H](C2CC2)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC[C@H]&C1=O",
"old_substring": "N14CCOC[C@H]17"
}
|
Can you make molecule Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCOC[C@H]1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCCC[C@@H](C2CC2)C1
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCOC[C@H]1C1CC1
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCCC[C@@H](C2CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC[C@@H]&C1",
"old_substring": "N14CCOC[C@H]17"
}
|
Can you make molecule Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCOC[C@H]1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCS[C@@H](C2CC2)C1
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCOC[C@H]1C1CC1
|
Cc1ccc(C(=O)N(C)C)cc1NC(=O)N1CCS[C@@H](C2CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCS[C@@H]&C1",
"old_substring": "N14CCOC[C@H]17"
}
|
Can you make molecule CN[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S[C@@H]2CCC[C@](C#N)(CN(C)C)C2)cc1C
|
CN[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1
|
Cc1ccc(S[C@@H]2CCC[C@](C#N)(CN(C)C)C2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CN(C)C&",
"old_substring": "CN3"
}
|
Can you make molecule CN[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S[C@@H]2CCC[C@](C#N)(CN=C=S)C2)cc1C
|
CN[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1
|
Cc1ccc(S[C@@H]2CCC[C@](C#N)(CN=C=S)C2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N=C=S",
"old_substring": "CN3"
}
|
Can you make molecule CN[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S[C@@H]2CCC[C@](C#N)(C3N=N3)C2)cc1C
|
CN[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1
|
Cc1ccc(S[C@@H]2CCC[C@](C#N)(C3N=N3)C2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&N=N1",
"old_substring": "CN3"
}
|
Can you make molecule CN[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C=N/O[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1
|
CN[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1
|
C/C=N/O[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C=N/O&",
"old_substring": "CN3"
}
|
Can you make molecule CN[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S[C@@H]2CCC[C@](C#N)(CC(N)=S)C2)cc1C
|
CN[C@@]1(C#N)CCC[C@@H](Sc2ccc(C)c(C)c2)C1
|
Cc1ccc(S[C@@H]2CCC[C@](C#N)(CC(N)=S)C2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(N)=S",
"old_substring": "CN3"
}
|
Can you make molecule Cc1cc([C@@H]([NH2+]CCN(C)C)C(=O)[O-])ccc1Br less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([C@@H]([NH2+]CCC(C)C)C(=O)[O-])ccc1Br
|
Cc1cc([C@@H]([NH2+]CCN(C)C)C(=O)[O-])ccc1Br
|
Cc1cc([C@@H]([NH2+]CCC(C)C)C(=O)[O-])ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "N4(C)C"
}
|
Can you make molecule Cc1cc([C@@H]([NH2+]CCN(C)C)C(=O)[O-])ccc1Br less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([C@@H]([NH2+]CCCC(=N)S)C(=O)[O-])ccc1Br
|
Cc1cc([C@@H]([NH2+]CCN(C)C)C(=O)[O-])ccc1Br
|
Cc1cc([C@@H]([NH2+]CCCC(=N)S)C(=O)[O-])ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "N=C(S)C&",
"old_substring": "N4(C)C"
}
|
Can you make molecule Cc1cc([C@@H]([NH2+]CCN(C)C)C(=O)[O-])ccc1Br less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([C@@H]([NH2+]CCN(C)C2=CCCC2)C(=O)[O-])ccc1Br
|
Cc1cc([C@@H]([NH2+]CCN(C)C)C(=O)[O-])ccc1Br
|
Cc1cc([C@@H]([NH2+]CCN(C)C2=CCCC2)C(=O)[O-])ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "N&(C)C1=CCCC1",
"old_substring": "N4(C)C"
}
|
Can you make molecule Cc1cc([C@@H]([NH2+]CCN(C)C)C(=O)[O-])ccc1Br less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([C@@H]([NH2+]CCC(F)(F)C#N)C(=O)[O-])ccc1Br
|
Cc1cc([C@@H]([NH2+]CCN(C)C)C(=O)[O-])ccc1Br
|
Cc1cc([C@@H]([NH2+]CCC(F)(F)C#N)C(=O)[O-])ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "N#CC&(F)F",
"old_substring": "N4(C)C"
}
|
Can you make molecule Cc1cc([C@@H]([NH2+]CCN(C)C)C(=O)[O-])ccc1Br less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([C@@H]([NH2+]CCCC(=N)[S-])C(=O)[O-])ccc1Br
|
Cc1cc([C@@H]([NH2+]CCN(C)C)C(=O)[O-])ccc1Br
|
Cc1cc([C@@H]([NH2+]CCCC(=N)[S-])C(=O)[O-])ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "N=C([S-])C&",
"old_substring": "N4(C)C"
}
|
Can you make molecule CCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
|
CCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
|
CCCCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CCC3=O"
}
|
Can you make molecule CCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
|
CCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
|
CCCCCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCC&=O",
"old_substring": "CCC3=O"
}
|
Can you make molecule CCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
|
CCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
|
CCCCCCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCCC&=O",
"old_substring": "CCC3=O"
}
|
Can you make molecule CCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)CCCc1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
|
CCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
|
CCC(=O)CCCc1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(=O)CCC&",
"old_substring": "CCC3=O"
}
|
Can you make molecule CCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)c1ccc2c(c1)c1cc(ON=C(CC)CC)ccc1n2C
|
CCC(=O)c1ccc2c(c1)c1cc(C(=O)CC)ccc1n2C
|
CCC(=O)c1ccc2c(c1)c1cc(ON=C(CC)CC)ccc1n2C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(CC)=NO&",
"old_substring": "CCC3=O"
}
|
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