prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)[N+](C)(C)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(C2CCCC2)c(C)c([C@H](C)C(=O)Nc2sc3c(c2C#N)CCCCC3)[nH+]1
|
C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)[N+](C)(C)C1CCCC1
|
Cc1nc(C2CCCC2)c(C)c([C@H](C)C(=O)Nc2sc3c(c2C#N)CCCCC3)[nH+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&[nH+]c(C)nc&c1C",
"old_substring": "[N+]46(C)C"
}
|
Can you make molecule C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)[N+](C)(C)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c([C@H](C)C(=O)Nc2sc3c(c2C#N)CCCCC3)n[nH+]c(C2CCCC2)c1C
|
C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)[N+](C)(C)C1CCCC1
|
Cc1c([C@H](C)C(=O)Nc2sc3c(c2C#N)CCCCC3)n[nH+]c(C2CCCC2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&n[nH+]c&c(C)c1C",
"old_substring": "[N+]46(C)C"
}
|
Can you make molecule C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)[N+](C)(C)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C[S@+]([O-])CCC1CCCC1)C(=O)Nc1sc2c(c1C#N)CCCCC2
|
C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)[N+](C)(C)C1CCCC1
|
C[C@@H](C[S@+]([O-])CCC1CCCC1)C(=O)Nc1sc2c(c1C#N)CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=[S@@](C&)CC&",
"old_substring": "[N+]46(C)C"
}
|
Can you make molecule C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)[N+](C)(C)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([C@H](C)C(=O)Nc2sc3c(c2C#N)CCCCC3)cc(C2CCCC2)[o+]1
|
C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)[N+](C)(C)C1CCCC1
|
Cc1cc([C@H](C)C(=O)Nc2sc3c(c2C#N)CCCCC3)cc(C2CCCC2)[o+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&[o+]c(C)c1",
"old_substring": "[N+]46(C)C"
}
|
Can you make molecule C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)[N+](C)(C)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)c1cc[n+](CC2CCCC2)cc1
|
C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)[N+](C)(C)C1CCCC1
|
C[C@H](C(=O)Nc1sc2c(c1C#N)CCCCC2)c1cc[n+](CC2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc[n+](C&)cc1",
"old_substring": "[N+]46(C)C"
}
|
Can you make molecule C[C@@H](Sc1nc2ccccc2n1C)c1ccc(OC(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(C)(C)c1ccc(OC(F)F)cc1)Sc1nc2ccccc2n1C
|
C[C@@H](Sc1nc2ccccc2n1C)c1ccc(OC(F)F)cc1
|
C[C@H](CC(C)(C)c1ccc(OC(F)F)cc1)Sc1nc2ccccc2n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@@H]45"
}
|
Can you make molecule C[C@@H](Sc1nc2ccccc2n1C)c1ccc(OC(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCSc1nc2ccccc2n1C)CC(=O)c1ccc(OC(F)F)cc1
|
C[C@@H](Sc1nc2ccccc2n1C)c1ccc(OC(F)F)cc1
|
C[C@@H](CCSc1nc2ccccc2n1C)CC(=O)c1ccc(OC(F)F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@@H]45"
}
|
Can you make molecule C[C@@H](Sc1nc2ccccc2n1C)c1ccc(OC(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(SCC[C@H](Cl)c2ccc(OC(F)F)cc2)nc2ccccc21
|
C[C@@H](Sc1nc2ccccc2n1C)c1ccc(OC(F)F)cc1
|
Cn1c(SCC[C@H](Cl)c2ccc(OC(F)F)cc2)nc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C[C@@H]&Cl",
"old_substring": "C[C@@H]45"
}
|
Can you make molecule C[C@@H](Sc1nc2ccccc2n1C)c1ccc(OC(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H](CC(=O)c1ccc(OC(F)F)cc1)Sc1nc2ccccc2n1C
|
C[C@@H](Sc1nc2ccccc2n1C)c1ccc(OC(F)F)cc1
|
CCC[C@H](CC(=O)c1ccc(OC(F)F)cc1)Sc1nc2ccccc2n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@@H]&CC&=O",
"old_substring": "C[C@@H]45"
}
|
Can you make molecule C[C@@H](Sc1nc2ccccc2n1C)c1ccc(OC(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](CCc1ccc(OC(F)F)cc1)Sc1nc2ccccc2n1C
|
C[C@@H](Sc1nc2ccccc2n1C)c1ccc(OC(F)F)cc1
|
CC(C)[C@H](CCc1ccc(OC(F)F)cc1)Sc1nc2ccccc2n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)[C@@H]&CC&",
"old_substring": "C[C@@H]45"
}
|
Can you make molecule O=C(CSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/SSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21
|
O=C(CSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21
|
O=C(/C=C/SSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(CSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C(=N[C@H]2CCCc3ccccc32)CCC1=[SH]c1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1
|
O=C(CSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21
|
O=C1C(=N[C@H]2CCCc3ccccc32)CCC1=[SH]c1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1C=&CCC1=&",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(CSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(c1ccc2oc(SN3CCC(=NON[C@H]4CCCc5ccccc54)CC3)nc2c1)N1CCOCC1
|
O=C(CSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21
|
O=S(=O)(c1ccc2oc(SN3CCC(=NON[C@H]4CCCc5ccccc54)CC3)nc2c1)N1CCOCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(CSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCN(Sc2nc3cc(S(=O)(=O)N4CCOCC4)ccc3o2)CC1)N[C@H]1CCCc2ccccc21
|
O=C(CSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21
|
O=C(NN=C1CCN(Sc2nc3cc(S(=O)(=O)N4CCOCC4)ccc3o2)CC1)N[C@H]1CCCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCN&CC1",
"old_substring": "O=C4C5"
}
|
Can you make molecule O=C(CSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(Sc2nc3cc(S(=O)(=O)N4CCOCC4)ccc3o2)CC1)N[C@H]1CCCc2ccccc21
|
O=C(CSc1nc2cc(S(=O)(=O)N3CCOCC3)ccc2o1)N[C@H]1CCCc2ccccc21
|
O=C(NN=C1CCC(Sc2nc3cc(S(=O)(=O)N4CCOCC4)ccc3o2)CC1)N[C@H]1CCCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C4C5"
}
|
Can you make molecule Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CSc1ncn[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2)c(C)c1CNSC(=O)CSc1ncn[nH]1
|
Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CSc1ncn[nH]1
|
Cc1nn(Cc2ccccc2)c(C)c1CNSC(=O)CSc1ncn[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C3(=O)C5"
}
|
Can you make molecule Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CSc1ncn[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CCCC(=O)Sc1ncn[nH]1
|
Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CSc1ncn[nH]1
|
Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CCCC(=O)Sc1ncn[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C3(=O)C5"
}
|
Can you make molecule Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CSc1ncn[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CC(C)(C)Sc1ncn[nH]1
|
Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CSc1ncn[nH]1
|
Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CC(C)(C)Sc1ncn[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C3(=O)C5"
}
|
Can you make molecule Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CSc1ncn[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2)c(C)c1CNC[S@+]([O-])CCCSc1ncn[nH]1
|
Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CSc1ncn[nH]1
|
Cc1nn(Cc2ccccc2)c(C)c1CNC[S@+]([O-])CCCSc1ncn[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C3(=O)C5"
}
|
Can you make molecule Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CSc1ncn[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CCC(C)(C)Sc1ncn[nH]1
|
Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CSc1ncn[nH]1
|
Cc1nn(Cc2ccccc2)c(C)c1CNC(=O)CCC(C)(C)Sc1ncn[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C3(=O)C5"
}
|
Can you make molecule CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1Cl
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Cl)c1Cl",
"old_substring": "c14ccc(Cl)c(Cl)c1"
}
|
Can you make molecule CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1cc(Cl)cc(Cl)c1Br
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1cc(Cl)cc(Cl)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Cl)cc(Cl)c1Br",
"old_substring": "c14ccc(Cl)c(Cl)c1"
}
|
Can you make molecule CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1c(Cl)ccc(Cl)c1Cl
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1c(Cl)ccc(Cl)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(Cl)ccc(Cl)c1Cl",
"old_substring": "c14ccc(Cl)c(Cl)c1"
}
|
Can you make molecule CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1c(Cl)cc(Cl)cc1Cl
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1c(Cl)cc(Cl)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(Cl)cc(Cl)cc1Cl",
"old_substring": "c14ccc(Cl)c(Cl)c1"
}
|
Can you make molecule CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1c(Cl)cc(Br)cc1Cl
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1ccc(Cl)c(Cl)c1
|
CC(=O)N1c2ccccc2NC2=C(C(=O)CCC2)[C@@H]1c1c(Cl)cc(Br)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(Cl)cc(Br)cc1Cl",
"old_substring": "c14ccc(Cl)c(Cl)c1"
}
|
Can you make molecule CCOC(=O)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)CC(C)(C)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
|
CCOC(=O)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
|
CCOC(=O)CC(C)(C)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule CCOC(=O)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)CCC(C)(C)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
|
CCOC(=O)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
|
CCOC(=O)CCC(C)(C)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule CCOC(=O)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)C[C@@H](Br)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
|
CCOC(=O)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
|
CCOC(=O)C[C@@H](Br)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C45=O"
}
|
Can you make molecule CCOC(=O)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=C(OOCC)c1ccc(N2CCN(c3nc(N4CCCC4)cc(C)c3C#N)CC2)cc1
|
CCOC(=O)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
|
C=C(OOCC)c1ccc(N2CCN(c3nc(N4CCCC4)cc(C)c3C#N)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C(O&)c1ccc&cc1",
"old_substring": "C45=O"
}
|
Can you make molecule CCOC(=O)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(CC)(CC)C(=O)CCN1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
|
CCOC(=O)N1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
|
CCOC(CC)(CC)C(=O)CCN1CCN(c2nc(N3CCCC3)cc(C)c2C#N)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C45=O"
}
|
Can you make molecule CCOC(=O)C1CCN(C(=O)c2cc3ccc(Cl)cc3n2C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)C1CCN(SC(=O)Cc2cc3ccc(Cl)cc3n2C)CC1
|
CCOC(=O)C1CCN(C(=O)c2cc3ccc(Cl)cc3n2C)CC1
|
CCOC(=O)C1CCN(SC(=O)Cc2cc3ccc(Cl)cc3n2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C57=O"
}
|
Can you make molecule CCOC(=O)C1CCN(C(=O)c2cc3ccc(Cl)cc3n2C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)C1CCN(C(=O)CCCC(=O)c2cc3ccc(Cl)cc3n2C)CC1
|
CCOC(=O)C1CCN(C(=O)c2cc3ccc(Cl)cc3n2C)CC1
|
CCOC(=O)C1CCN(C(=O)CCCC(=O)c2cc3ccc(Cl)cc3n2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C57=O"
}
|
Can you make molecule CCOC(=O)C1CCN(C(=O)c2cc3ccc(Cl)cc3n2C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)C1CCN(C(=O)CC(C)(C)c2cc3ccc(Cl)cc3n2C)CC1
|
CCOC(=O)C1CCN(C(=O)c2cc3ccc(Cl)cc3n2C)CC1
|
CCOC(=O)C1CCN(C(=O)CC(C)(C)c2cc3ccc(Cl)cc3n2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C57=O"
}
|
Can you make molecule CCOC(=O)C1CCN(C(=O)c2cc3ccc(Cl)cc3n2C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)C1CCN(C(=O)CCC(C)(C)c2cc3ccc(Cl)cc3n2C)CC1
|
CCOC(=O)C1CCN(C(=O)c2cc3ccc(Cl)cc3n2C)CC1
|
CCOC(=O)C1CCN(C(=O)CCC(C)(C)c2cc3ccc(Cl)cc3n2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C57=O"
}
|
Can you make molecule CCOC(=O)C1CCN(C(=O)c2cc3ccc(Cl)cc3n2C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)C1CCN(SC(=O)[C@@H](C)c2cc3ccc(Cl)cc3n2C)CC1
|
CCOC(=O)C1CCN(C(=O)c2cc3ccc(Cl)cc3n2C)CC1
|
CCOC(=O)C1CCN(SC(=O)[C@@H](C)c2cc3ccc(Cl)cc3n2C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C57=O"
}
|
Can you make molecule NC(=O)N1CCC[C@H](C(=O)N2CCC(C(=O)[O-])CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)N1CCC[C@H](CC(=O)SN2CCC(C(=O)[O-])CC2)C1
|
NC(=O)N1CCC[C@H](C(=O)N2CCC(C(=O)[O-])CC2)C1
|
NC(=O)N1CCC[C@H](CC(=O)SN2CCC(C(=O)[O-])CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C45=O"
}
|
Can you make molecule NC(=O)N1CCC[C@H](C(=O)N2CCC(C(=O)[O-])CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)N1CCC[C@H](CC(=C=O)CN2CCC(C(=O)[O-])CC2)C1
|
NC(=O)N1CCC[C@H](C(=O)N2CCC(C(=O)[O-])CC2)C1
|
NC(=O)N1CCC[C@H](CC(=C=O)CN2CCC(C(=O)[O-])CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C45=O"
}
|
Can you make molecule NC(=O)N1CCC[C@H](C(=O)N2CCC(C(=O)[O-])CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)N1CCC[C@H](C(=O)CCCC(=O)N2CCC(C(=O)[O-])CC2)C1
|
NC(=O)N1CCC[C@H](C(=O)N2CCC(C(=O)[O-])CC2)C1
|
NC(=O)N1CCC[C@H](C(=O)CCCC(=O)N2CCC(C(=O)[O-])CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C45=O"
}
|
Can you make molecule NC(=O)N1CCC[C@H](C(=O)N2CCC(C(=O)[O-])CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)N1CCC(C(=O)[O-])CC1)[C@H]1CCCN(C(N)=O)C1
|
NC(=O)N1CCC[C@H](C(=O)N2CCC(C(=O)[O-])CC2)C1
|
CC(C)(CC(=O)N1CCC(C(=O)[O-])CC1)[C@H]1CCCN(C(N)=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule NC(=O)N1CCC[C@H](C(=O)N2CCC(C(=O)[O-])CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)N1CCC[C@H](CCC[S@@+]([O-])CN2CCC(C(=O)[O-])CC2)C1
|
NC(=O)N1CCC[C@H](C(=O)N2CCC(C(=O)[O-])CC2)C1
|
NC(=O)N1CCC[C@H](CCC[S@@+]([O-])CN2CCC(C(=O)[O-])CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C45=O"
}
|
Can you make molecule COc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC
|
COc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC
|
COCc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC
|
COc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC
|
COCSc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N/C=C1/C(=O)N(c2ccc(C)cc2C)C(=O)c2cc(SC(C)=O)ccc21
|
COc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC
|
COc1ccccc1N/C=C1/C(=O)N(c2ccc(C)cc2C)C(=O)c2cc(SC(C)=O)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N/C=C1/C(=O)N(c2ccc(C)cc2C)C(=O)c2cc(C(=O)CS)ccc21
|
COc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC
|
COc1ccccc1N/C=C1/C(=O)N(c2ccc(C)cc2C)C(=O)c2cc(C(=O)CS)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N/C=C1/C(=O)N(c2ccc(C)cc2C)C(=O)c2cc(C(=O)CI)ccc21
|
COc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC
|
COc1ccccc1N/C=C1/C(=O)N(c2ccc(C)cc2C)C(=O)c2cc(C(=O)CI)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1
|
COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1
|
COCc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1
|
COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1
|
COCSc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(SC(C)=O)cc1N1CC(=O)C(c2nc3ccccc3s2)=C1N
|
COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1
|
COc1ccc(SC(C)=O)cc1N1CC(=O)C(c2nc3ccccc3s2)=C1N
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)CS)cc1N1CC(=O)C(c2nc3ccccc3s2)=C1N
|
COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1
|
COc1ccc(C(=O)CS)cc1N1CC(=O)C(c2nc3ccccc3s2)=C1N
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)CI)cc1N1CC(=O)C(c2nc3ccccc3s2)=C1N
|
COc1ccc(OC)c(N2CC(=O)C(c3nc4ccccc4s3)=C2N)c1
|
COc1ccc(C(=O)CI)cc1N1CC(=O)C(c2nc3ccccc3s2)=C1N
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO5"
}
|
Can you make molecule CCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)=N[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
|
CCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
|
CC(C)=N[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&C",
"old_substring": "CC4"
}
|
Can you make molecule CCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
|
CCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
|
C=CSN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC4"
}
|
Can you make molecule CCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(I)=N[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
|
CCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
|
CC(I)=N[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&I",
"old_substring": "CC4"
}
|
Can you make molecule CCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
|
CCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
|
C=CCCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC4"
}
|
Can you make molecule CCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CC[C@@H]([NH+]2CCC[C@H]3CCC[C@@H]32)[C@H]1N=CCCl
|
CCN[C@@H]1[C@H]([NH+]2CCC[C@H]3CCC[C@@H]32)CCC1(C)C
|
CC1(C)CC[C@@H]([NH+]2CCC[C@H]3CCC[C@@H]32)[C@H]1N=CCCl
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CCl",
"old_substring": "CC4"
}
|
Can you make molecule O=C(CCCc1nc2ccccc2s1)N1CCC[NH+](Cc2ccc(F)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(c2nc3ccccc3s2)CC1)N1CCC[NH+](Cc2ccc(F)cc2)CC1
|
O=C(CCCc1nc2ccccc2s1)N1CCC[NH+](Cc2ccc(F)cc2)CC1
|
O=C(NN=C1CCC(c2nc3ccccc3s2)CC1)N1CCC[NH+](Cc2ccc(F)cc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C3CCC5"
}
|
Can you make molecule O=C(CCCc1nc2ccccc2s1)N1CCC[NH+](Cc2ccc(F)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C1=CC[C@H](c2nc3ccccc3s2)S1)N1CCC[NH+](Cc2ccc(F)cc2)CC1
|
O=C(CCCc1nc2ccccc2s1)N1CCC[NH+](Cc2ccc(F)cc2)CC1
|
O=C(C1=CC[C@H](c2nc3ccccc3s2)S1)N1CCC[NH+](Cc2ccc(F)cc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&C1=CC[C@H]&S1",
"old_substring": "O=C3CCC5"
}
|
Can you make molecule O=C(CCCc1nc2ccccc2s1)N1CCC[NH+](Cc2ccc(F)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc(C[NH+]2CCCN(CCCCCc3nc4ccccc4s3)CC2)cc1
|
O=C(CCCc1nc2ccccc2s1)N1CCC[NH+](Cc2ccc(F)cc2)CC1
|
Fc1ccc(C[NH+]2CCCN(CCCCCc3nc4ccccc4s3)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "O=C3CCC5"
}
|
Can you make molecule O=C(CCCc1nc2ccccc2s1)N1CCC[NH+](Cc2ccc(F)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)N1CCC[NH+](Cc2ccc(F)cc2)CC1)c1nc2ccccc2s1
|
O=C(CCCc1nc2ccccc2s1)N1CCC[NH+](Cc2ccc(F)cc2)CC1
|
CC(C)(CCC(=O)N1CCC[NH+](Cc2ccc(F)cc2)CC1)c1nc2ccccc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "O=C3CCC5"
}
|
Can you make molecule O=C(CCCc1nc2ccccc2s1)N1CCC[NH+](Cc2ccc(F)cc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCCc1nc2ccccc2s1)C(=O)N1CCC[NH+](Cc2ccc(F)cc2)CC1
|
O=C(CCCc1nc2ccccc2s1)N1CCC[NH+](Cc2ccc(F)cc2)CC1
|
CC(C)(CCCc1nc2ccccc2s1)C(=O)N1CCC[NH+](Cc2ccc(F)cc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)CCC&",
"old_substring": "O=C3CCC5"
}
|
Can you make molecule COC(C)(C)CNC(=O)COC1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSC(C)(C)CNC(=O)COC1CCCC1
|
COC(C)(C)CNC(=O)COC1CCCC1
|
COCSC(C)(C)CNC(=O)COC1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COC(C)(C)CNC(=O)COC1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)SC(C)(C)CNC(=O)COC1CCCC1
|
COC(C)(C)CNC(=O)COC1CCCC1
|
CC(=O)SC(C)(C)CNC(=O)COC1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COC(C)(C)CNC(=O)COC1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CNC(=O)COC1CCCC1)C(=O)CI
|
COC(C)(C)CNC(=O)COC1CCCC1
|
CC(C)(CNC(=O)COC1CCCC1)C(=O)CI
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
}
|
Can you make molecule COC(C)(C)CNC(=O)COC1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CNC(=O)COC1CCCC1)C(=O)CBr
|
COC(C)(C)CNC(=O)COC1CCCC1
|
CC(C)(CNC(=O)COC1CCCC1)C(=O)CBr
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CBr",
"old_substring": "CO3"
}
|
Can you make molecule COC(C)(C)CNC(=O)COC1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CON(C)CCCC(C)(C)CNC(=O)COC1CCCC1
|
COC(C)(C)CNC(=O)COC1CCCC1
|
CON(C)CCCC(C)(C)CNC(=O)COC1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CON(C)CCC&",
"old_substring": "CO3"
}
|
Can you make molecule Cc1cc(C(=O)Nc2ccc(C#N)cc2)c2ccccc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(CC(=O)SNc2ccc(C#N)cc2)c2ccccc2n1
|
Cc1cc(C(=O)Nc2ccc(C#N)cc2)c2ccccc2n1
|
Cc1cc(CC(=O)SNc2ccc(C#N)cc2)c2ccccc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1cc(C(=O)Nc2ccc(C#N)cc2)c2ccccc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)CCCC(=O)Nc2ccc(C#N)cc2)c2ccccc2n1
|
Cc1cc(C(=O)Nc2ccc(C#N)cc2)c2ccccc2n1
|
Cc1cc(C(=O)CCCC(=O)Nc2ccc(C#N)cc2)c2ccccc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1cc(C(=O)Nc2ccc(C#N)cc2)c2ccccc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(C)(C)CC(=O)Nc2ccc(C#N)cc2)c2ccccc2n1
|
Cc1cc(C(=O)Nc2ccc(C#N)cc2)c2ccccc2n1
|
Cc1cc(C(C)(C)CC(=O)Nc2ccc(C#N)cc2)c2ccccc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1cc(C(=O)Nc2ccc(C#N)cc2)c2ccccc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(C)(C)CCC(=O)Nc2ccc(C#N)cc2)c2ccccc2n1
|
Cc1cc(C(=O)Nc2ccc(C#N)cc2)c2ccccc2n1
|
Cc1cc(C(C)(C)CCC(=O)Nc2ccc(C#N)cc2)c2ccccc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1cc(C(=O)Nc2ccc(C#N)cc2)c2ccccc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc([C@H](C)C(=O)SNc2ccc(C#N)cc2)c2ccccc2n1
|
Cc1cc(C(=O)Nc2ccc(C#N)cc2)c2ccccc2n1
|
Cc1cc([C@H](C)C(=O)SNc2ccc(C#N)cc2)c2ccccc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule Cn1cnc(C[NH2+]Cc2ccc(C(C)(C)C)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cnc(CCCC[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
|
Cn1cnc(C[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
|
Cn1cnc(CCCC[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C35"
}
|
Can you make molecule Cn1cnc(C[NH2+]Cc2ccc(C(C)(C)C)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cnc(CCCCC[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
|
Cn1cnc(C[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
|
Cn1cnc(CCCCC[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C35"
}
|
Can you make molecule Cn1cnc(C[NH2+]Cc2ccc(C(C)(C)C)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cnc(C2CC([NH2+]Cc3ccc(C(C)(C)C)cc3)C2)n1
|
Cn1cnc(C[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
|
Cn1cnc(C2CC([NH2+]Cc3ccc(C(C)(C)C)cc3)C2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C35"
}
|
Can you make molecule Cn1cnc(C[NH2+]Cc2ccc(C(C)(C)C)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cnc(SC(=S)O[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
|
Cn1cnc(C[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
|
Cn1cnc(SC(=S)O[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C35"
}
|
Can you make molecule Cn1cnc(C[NH2+]Cc2ccc(C(C)(C)C)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cnc(NC(=S)S[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
|
Cn1cnc(C[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
|
Cn1cnc(NC(=S)S[NH2+]Cc2ccc(C(C)(C)C)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C35"
}
|
Can you make molecule Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)[O-])c2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(CCS(=O)(=O)[O-])c2c1
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)[O-])c2c1
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(CCS(=O)(=O)[O-])c2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CS(=O)(=O)[O-]",
"old_substring": "C5(=O)[O-]"
}
|
Can you make molecule Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)[O-])c2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)CO)c2c1
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)[O-])c2c1
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)CO)c2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CO",
"old_substring": "C5(=O)[O-]"
}
|
Can you make molecule Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)[O-])c2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(O)O)c2c1
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)[O-])c2c1
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(O)O)c2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(O)O",
"old_substring": "C5(=O)[O-]"
}
|
Can you make molecule Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)[O-])c2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)[O-])c1c(C)oc2ccc(NS(=O)(=O)c3ccc(F)cc3C)cc12
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)[O-])c2c1
|
CCC(CC)(C(=O)[O-])c1c(C)oc2ccc(NS(=O)(=O)c3ccc(F)cc3C)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)[O-]",
"old_substring": "C5(=O)[O-]"
}
|
Can you make molecule Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)[O-])c2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(CCCS(=O)(=O)[O-])c2c1
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(C(=O)[O-])c2c1
|
Cc1cc(F)ccc1S(=O)(=O)Nc1ccc2oc(C)c(CCCS(=O)(=O)[O-])c2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCS(=O)(=O)[O-]",
"old_substring": "C5(=O)[O-]"
}
|
Can you make molecule [NH3+][C@@H]1CCCCC[C@H]1C(=O)NCCC1=CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H]1CCCCC[C@H]1CC(=O)SNCCC1=CCCCC1
|
[NH3+][C@@H]1CCCCC[C@H]1C(=O)NCCC1=CCCCC1
|
[NH3+][C@@H]1CCCCC[C@H]1CC(=O)SNCCC1=CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule [NH3+][C@@H]1CCCCC[C@H]1C(=O)NCCC1=CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H]1CCCCC[C@H]1CC(=C=O)CNCCC1=CCCCC1
|
[NH3+][C@@H]1CCCCC[C@H]1C(=O)NCCC1=CCCCC1
|
[NH3+][C@@H]1CCCCC[C@H]1CC(=C=O)CNCCC1=CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule [NH3+][C@@H]1CCCCC[C@H]1C(=O)NCCC1=CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H]1CCCCC[C@H]1C(=O)CCCC(=O)NCCC1=CCCCC1
|
[NH3+][C@@H]1CCCCC[C@H]1C(=O)NCCC1=CCCCC1
|
[NH3+][C@@H]1CCCCC[C@H]1C(=O)CCCC(=O)NCCC1=CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C24=O"
}
|
Can you make molecule [NH3+][C@@H]1CCCCC[C@H]1C(=O)NCCC1=CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)NCCC1=CCCCC1)[C@@H]1CCCCC[C@H]1[NH3+]
|
[NH3+][C@@H]1CCCCC[C@H]1C(=O)NCCC1=CCCCC1
|
CC(C)(CC(=O)NCCC1=CCCCC1)[C@@H]1CCCCC[C@H]1[NH3+]
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule [NH3+][C@@H]1CCCCC[C@H]1C(=O)NCCC1=CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H]1CCCCC[C@H]1CCC[S@@+]([O-])CNCCC1=CCCCC1
|
[NH3+][C@@H]1CCCCC[C@H]1C(=O)NCCC1=CCCCC1
|
[NH3+][C@@H]1CCCCC[C@H]1CCC[S@@+]([O-])CNCCC1=CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C24=O"
}
|
Can you make molecule Cc1cnc(-c2cccc(NC(=O)C(=O)N[C@@H]3CCN(c4ccccc4)C3)c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccoc1.O=C(Nc1ccccc1)C(=O)N[C@@H]1CCN(c2ccccc2)C1
|
Cc1cnc(-c2cccc(NC(=O)C(=O)N[C@@H]3CCN(c4ccccc4)C3)c2)o1
|
Cc1ccoc1.O=C(Nc1ccccc1)C(=O)N[C@@H]1CCN(c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccoc1&",
"old_substring": "Cc1cnc%10o1"
}
|
Can you make molecule Cc1cnc(-c2cccc(NC(=O)C(=O)N[C@@H]3CCN(c4ccccc4)C3)c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc[nH]c1.O=C(Nc1ccccc1)C(=O)N[C@@H]1CCN(c2ccccc2)C1
|
Cc1cnc(-c2cccc(NC(=O)C(=O)N[C@@H]3CCN(c4ccccc4)C3)c2)o1
|
Cc1cc[nH]c1.O=C(Nc1ccccc1)C(=O)N[C@@H]1CCN(c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c[nH]c&c1",
"old_substring": "Cc1cnc%10o1"
}
|
Can you make molecule Cc1cnc(-c2cccc(NC(=O)C(=O)N[C@@H]3CCN(c4ccccc4)C3)c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccn1C.O=C(Nc1ccccc1)C(=O)N[C@@H]1CCN(c2ccccc2)C1
|
Cc1cnc(-c2cccc(NC(=O)C(=O)N[C@@H]3CCN(c4ccccc4)C3)c2)o1
|
Cc1cccn1C.O=C(Nc1ccccc1)C(=O)N[C@@H]1CCN(c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&n1C",
"old_substring": "Cc1cnc%10o1"
}
|
Can you make molecule Cc1cnc(-c2cccc(NC(=O)C(=O)N[C@@H]3CCN(c4ccccc4)C3)c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cncc(C)c1.O=C(Nc1ccccc1)C(=O)N[C@@H]1CCN(c2ccccc2)C1
|
Cc1cnc(-c2cccc(NC(=O)C(=O)N[C@@H]3CCN(c4ccccc4)C3)c2)o1
|
Cc1cncc(C)c1.O=C(Nc1ccccc1)C(=O)N[C@@H]1CCN(c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cnc&c(C)c1",
"old_substring": "Cc1cnc%10o1"
}
|
Can you make molecule Cc1cnc(-c2cccc(NC(=O)C(=O)N[C@@H]3CCN(c4ccccc4)C3)c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccsn1.O=C(Nc1ccccc1)C(=O)N[C@@H]1CCN(c2ccccc2)C1
|
Cc1cnc(-c2cccc(NC(=O)C(=O)N[C@@H]3CCN(c4ccccc4)C3)c2)o1
|
Cc1ccsn1.O=C(Nc1ccccc1)C(=O)N[C@@H]1CCN(c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nscc1&",
"old_substring": "Cc1cnc%10o1"
}
|
Can you make molecule c1ccc(COCCc2ncnc3sccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
c1ccc(CCCCOCCc2ncnc3sccc23)cc1
|
c1ccc(COCCc2ncnc3sccc23)cc1
|
c1ccc(CCCCOCCc2ncnc3sccc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C47"
}
|
Can you make molecule c1ccc(COCCc2ncnc3sccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
c1ccc(CCCCCOCCc2ncnc3sccc23)cc1
|
c1ccc(COCCc2ncnc3sccc23)cc1
|
c1ccc(CCCCCOCCc2ncnc3sccc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C47"
}
|
Can you make molecule c1ccc(COCCc2ncnc3sccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
c1ccc(C2CC(OCCc3ncnc4sccc34)C2)cc1
|
c1ccc(COCCc2ncnc3sccc23)cc1
|
c1ccc(C2CC(OCCc3ncnc4sccc34)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C47"
}
|
Can you make molecule c1ccc(COCCc2ncnc3sccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
S=C(OOCCc1ncnc2sccc12)Sc1ccccc1
|
c1ccc(COCCc2ncnc3sccc23)cc1
|
S=C(OOCCc1ncnc2sccc12)Sc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C47"
}
|
Can you make molecule c1ccc(COCCc2ncnc3sccc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
S=C(Nc1ccccc1)SOCCc1ncnc2sccc12
|
c1ccc(COCCc2ncnc3sccc23)cc1
|
S=C(Nc1ccccc1)SOCCc1ncnc2sccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C47"
}
|
Can you make molecule CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCCC3)ccc21
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCCC3)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCCCC3)ccc21
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCCCC3)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCSCC3)ccc21
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCSCC3)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSCC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CC=CC3)ccc21
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CC=CC3)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC=CC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)SSN3CCOCC3)ccc21
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)N3CCOCC3)ccc21
|
CCCn1c(CN2CCN(c3cccc[nH+]3)CC2)nc2cc(S(=O)(=O)SSN3CCOCC3)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SN1CCOCC1",
"old_substring": "N15CCOCC1"
}
|
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