prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CC(C)c1c(CO)cnn1Cc1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cnn(Cc2cccc(Cl)c2)c1C(C)C
|
CC(C)c1c(CO)cnn1Cc1cccc(Cl)c1
|
COCc1cnn(Cc2cccc(Cl)c2)c1C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "C4O"
}
|
Can you make molecule CC(C)c1c(CO)cnn1Cc1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1cnn(Cc2cccc(Cl)c2)c1C(C)C
|
CC(C)c1c(CO)cnn1Cc1cccc(Cl)c1
|
COCSc1cnn(Cc2cccc(Cl)c2)c1C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "C4O"
}
|
Can you make molecule CC(C)c1c(CO)cnn1Cc1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=COc1cnn(Cc2cccc(Cl)c2)c1C(C)C
|
CC(C)c1c(CO)cnn1Cc1cccc(Cl)c1
|
C=COc1cnn(Cc2cccc(Cl)c2)c1C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CO&",
"old_substring": "C4O"
}
|
Can you make molecule CC(C)c1c(CO)cnn1Cc1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1c(C2COC2)cnn1Cc1cccc(Cl)c1
|
CC(C)c1c(CO)cnn1Cc1cccc(Cl)c1
|
CC(C)c1c(C2COC2)cnn1Cc1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&COC1",
"old_substring": "C4O"
}
|
Can you make molecule CC(C)c1c(CO)cnn1Cc1cccc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1c(C(=O)S)cnn1Cc1cccc(Cl)c1
|
CC(C)c1c(CO)cnn1Cc1cccc(Cl)c1
|
CC(C)c1c(C(=O)S)cnn1Cc1cccc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)S",
"old_substring": "C4O"
}
|
Can you make molecule Cc1nc(Cn2cc(N)cn2)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(Cn2cc(C#N)cn2)sc1C
|
Cc1nc(Cn2cc(N)cn2)sc1C
|
Cc1nc(Cn2cc(C#N)cn2)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc(C#N)cn1",
"old_substring": "n13cc(N)cn1"
}
|
Can you make molecule Cc1nc(Cn2cc(N)cn2)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(Cn2cc(I)cn2)sc1C
|
Cc1nc(Cn2cc(N)cn2)sc1C
|
Cc1nc(Cn2cc(I)cn2)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc(I)cn1",
"old_substring": "n13cc(N)cn1"
}
|
Can you make molecule Cc1nc(Cn2cc(N)cn2)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccn(Cc2nc(C)c(C)s2)n1
|
Cc1nc(Cn2cc(N)cn2)sc1C
|
Cc1ccn(Cc2nc(C)c(C)s2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccc(C)n1",
"old_substring": "n13cc(N)cn1"
}
|
Can you make molecule Cc1nc(Cn2cc(N)cn2)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cn(Cc2nc(C)c(C)s2)nc1I
|
Cc1nc(Cn2cc(N)cn2)sc1C
|
Cc1cn(Cc2nc(C)c(C)s2)nc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc(C)c(I)n1",
"old_substring": "n13cc(N)cn1"
}
|
Can you make molecule Cc1nc(Cn2cc(N)cn2)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2nc(C)c(C)s2)cc1Cl
|
Cc1nc(Cn2cc(N)cn2)sc1C
|
Cc1nn(Cc2nc(C)c(C)s2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc(Cl)c(C)n1",
"old_substring": "n13cc(N)cn1"
}
|
Can you make molecule CC(C)CN1CCO[C@@H](CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN1CCO[C@@H](CNSC(=O)C[C@]23CC[C@H](C[C@@H]2Br)C3)C1
|
CC(C)CN1CCO[C@@H](CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1
|
CC(C)CN1CCO[C@@H](CNSC(=O)C[C@]23CC[C@H](C[C@@H]2Br)C3)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule CC(C)CN1CCO[C@@H](CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN1CCO[C@@H](CNCC(=C=O)C[C@]23CC[C@H](C[C@@H]2Br)C3)C1
|
CC(C)CN1CCO[C@@H](CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1
|
CC(C)CN1CCO[C@@H](CNCC(=C=O)C[C@]23CC[C@H](C[C@@H]2Br)C3)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule CC(C)CN1CCO[C@@H](CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN1CCO[C@@H](CNC(=O)CCCC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1
|
CC(C)CN1CCO[C@@H](CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1
|
CC(C)CN1CCO[C@@H](CNC(=O)CCCC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
}
|
Can you make molecule CC(C)CN1CCO[C@@H](CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN1CCO[C@@H](CNC(=O)CC(C)(C)[C@]23CC[C@H](C[C@@H]2Br)C3)C1
|
CC(C)CN1CCO[C@@H](CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1
|
CC(C)CN1CCO[C@@H](CNC(=O)CC(C)(C)[C@]23CC[C@H](C[C@@H]2Br)C3)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule CC(C)CN1CCO[C@@H](CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CN1CCO[C@@H](CNC[S@+]([O-])CCC[C@]23CC[C@H](C[C@@H]2Br)C3)C1
|
CC(C)CN1CCO[C@@H](CNC(=O)[C@]23CC[C@H](C[C@@H]2Br)C3)C1
|
CC(C)CN1CCO[C@@H](CNC[S@+]([O-])CCC[C@]23CC[C@H](C[C@@H]2Br)C3)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C47=O"
}
|
Can you make molecule CCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C
|
CCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C
|
C=CSN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC3"
}
|
Can you make molecule CCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C
|
CCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C
|
C=CCCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCN(CCCCl)[C@]1(C[NH3+])CCCS[C@@H]1C
|
CCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C
|
COCCN(CCCCl)[C@]1(C[NH3+])CCCS[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCN(CCCCS)[C@]1(C[NH3+])CCCS[C@@H]1C
|
CCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C
|
COCCN(CCCCS)[C@]1(C[NH3+])CCCS[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule CCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
COCCN(CCCBr)[C@]1(C[NH3+])CCCS[C@@H]1C
|
CCN(CCOC)[C@]1(C[NH3+])CCCS[C@@H]1C
|
COCCN(CCCBr)[C@]1(C[NH3+])CCCS[C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC3"
}
|
Can you make molecule Cc1cc(NC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NSC(=O)Cc2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
|
Cc1cc(NC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
|
Cc1cc(NSC(=O)Cc2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1cc(NC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)CCCC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
|
Cc1cc(NC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
|
Cc1cc(NC(=O)CCCC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1cc(NC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)CC(C)(C)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
|
Cc1cc(NC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
|
Cc1cc(NC(=O)CC(C)(C)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1cc(NC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)CCC(C)(C)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
|
Cc1cc(NC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
|
Cc1cc(NC(=O)CCC(C)(C)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1cc(NC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NSC(=O)[C@@H](C)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
|
Cc1cc(NC(=O)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
|
Cc1cc(NSC(=O)[C@@H](C)c2ccc(SC(F)F)cc2)c(C(N)=O)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule CCCc1cc(NC(=O)N(C)[C@H]2CCN(c3ccccc3F)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cc(NC(=O)N(C)[C@H]2CCCCN(c3ccccc3F)C2=O)n(C)n1
|
CCCc1cc(NC(=O)N(C)[C@H]2CCN(c3ccccc3F)C2=O)n(C)n1
|
CCCc1cc(NC(=O)N(C)[C@H]2CCCCN(c3ccccc3F)C2=O)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCCN&C1=O",
"old_substring": "[C@H]17CCN9C1=O"
}
|
Can you make molecule CCCc1cc(NC(=O)N(C)[C@H]2CCN(c3ccccc3F)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cc(NC(=O)N(C)[C@H]2CC(Cc3ccccc3F)=NO2)n(C)n1
|
CCCc1cc(NC(=O)N(C)[C@H]2CCN(c3ccccc3F)C2=O)n(C)n1
|
CCCc1cc(NC(=O)N(C)[C@H]2CC(Cc3ccccc3F)=NO2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC(C&)=NO1",
"old_substring": "[C@H]17CCN9C1=O"
}
|
Can you make molecule CCCc1cc(NC(=O)N(C)[C@H]2CCN(c3ccccc3F)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cc(NC(=O)N(C)[C@H]2C=C(Cc3ccccc3F)ON2)n(C)n1
|
CCCc1cc(NC(=O)N(C)[C@H]2CCN(c3ccccc3F)C2=O)n(C)n1
|
CCCc1cc(NC(=O)N(C)[C@H]2C=C(Cc3ccccc3F)ON2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C(C&)ON1",
"old_substring": "[C@H]17CCN9C1=O"
}
|
Can you make molecule CCCc1cc(NC(=O)N(C)[C@H]2CCN(c3ccccc3F)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cc(NC(=O)N(C)[C@@H]2CCCCN(c3ccccc3F)C2=O)n(C)n1
|
CCCc1cc(NC(=O)N(C)[C@H]2CCN(c3ccccc3F)C2=O)n(C)n1
|
CCCc1cc(NC(=O)N(C)[C@@H]2CCCCN(c3ccccc3F)C2=O)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCCN&C1=O",
"old_substring": "[C@H]17CCN9C1=O"
}
|
Can you make molecule CCCc1cc(NC(=O)N(C)[C@H]2CCN(c3ccccc3F)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cc(NC(=O)N(C)[C@H]2CCCCN(c3ccccc3F)C2)n(C)n1
|
CCCc1cc(NC(=O)N(C)[C@H]2CCN(c3ccccc3F)C2=O)n(C)n1
|
CCCc1cc(NC(=O)N(C)[C@H]2CCCCN(c3ccccc3F)C2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCCN&C1",
"old_substring": "[C@H]17CCN9C1=O"
}
|
Can you make molecule Cc1cccc(NC(=O)N(C)Cc2sccc2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)c2cc(C#N)c(Cc3sccc3C)s2)c1
|
Cc1cccc(NC(=O)N(C)Cc2sccc2C)c1
|
Cc1cccc(NC(=O)c2cc(C#N)c(Cc3sccc3C)s2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N45C"
}
|
Can you make molecule Cc1cccc(NC(=O)N(C)Cc2sccc2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)c2ccc(Cc3sccc3C)c(C#N)c2)c1
|
Cc1cccc(NC(=O)N(C)Cc2sccc2C)c1
|
Cc1cccc(NC(=O)c2ccc(Cc3sccc3C)c(C#N)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N45C"
}
|
Can you make molecule Cc1cccc(NC(=O)N(C)Cc2sccc2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)ON=C2CCN(Cc3sccc3C)CC2)c1
|
Cc1cccc(NC(=O)N(C)Cc2sccc2C)c1
|
Cc1cccc(NC(=O)ON=C2CCN(Cc3sccc3C)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "N45C"
}
|
Can you make molecule Cc1cccc(NC(=O)N(C)Cc2sccc2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)N2CCC=C(CCc3sccc3C)C2)c1
|
Cc1cccc(NC(=O)N(C)Cc2sccc2C)c1
|
Cc1cccc(NC(=O)N2CCC=C(CCc3sccc3C)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC=C(C&)C1",
"old_substring": "N45C"
}
|
Can you make molecule Cc1cccc(NC(=O)N(C)Cc2sccc2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(NC(=O)N2Cc3nc(Cc4sccc4C)sc3C2)c1
|
Cc1cccc(NC(=O)N(C)Cc2sccc2C)c1
|
Cc1cccc(NC(=O)N2Cc3nc(Cc4sccc4C)sc3C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&Cc2nc&sc2C1",
"old_substring": "N45C"
}
|
Can you make molecule O=S(=O)(Oc1ccc(-n2cnnn2)cc1)c1ccc(Br)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(Oc1ccc(-n2cnnn2)cc1I)c1ccc(Br)cc1Cl
|
O=S(=O)(Oc1ccc(-n2cnnn2)cc1)c1ccc(Br)cc1Cl
|
O=S(=O)(Oc1ccc(-n2cnnn2)cc1I)c1ccc(Br)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c13ccc4cc1"
}
|
Can you make molecule O=S(=O)(Oc1ccc(-n2cnnn2)cc1)c1ccc(Br)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(Oc1cc(-n2cnnn2)ccc1Br)c1ccc(Br)cc1Cl
|
O=S(=O)(Oc1ccc(-n2cnnn2)cc1)c1ccc(Br)cc1Cl
|
O=S(=O)(Oc1cc(-n2cnnn2)ccc1Br)c1ccc(Br)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c13ccc4cc1"
}
|
Can you make molecule O=S(=O)(Oc1ccc(-n2cnnn2)cc1)c1ccc(Br)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(Oc1ccc(-n2cnnn2)cc1Cl)c1ccc(Br)cc1Cl
|
O=S(=O)(Oc1ccc(-n2cnnn2)cc1)c1ccc(Br)cc1Cl
|
O=S(=O)(Oc1ccc(-n2cnnn2)cc1Cl)c1ccc(Br)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c13ccc4cc1"
}
|
Can you make molecule O=S(=O)(Oc1ccc(-n2cnnn2)cc1)c1ccc(Br)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(Oc1cccc(-n2cnnn2)c1Br)c1ccc(Br)cc1Cl
|
O=S(=O)(Oc1ccc(-n2cnnn2)cc1)c1ccc(Br)cc1Cl
|
O=S(=O)(Oc1cccc(-n2cnnn2)c1Br)c1ccc(Br)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c13ccc4cc1"
}
|
Can you make molecule O=S(=O)(Oc1ccc(-n2cnnn2)cc1)c1ccc(Br)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(Oc1cccc(-n2cnnn2)c1Cl)c1ccc(Br)cc1Cl
|
O=S(=O)(Oc1ccc(-n2cnnn2)cc1)c1ccc(Br)cc1Cl
|
O=S(=O)(Oc1cccc(-n2cnnn2)c1Cl)c1ccc(Br)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c13ccc4cc1"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(=O)NCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(C)(C)CNCc1ccccc1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(=O)NCc1ccccc1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(C)(C)CNCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(C)C(C)(C)C&",
"old_substring": "[C@@H]5(C)C4=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(=O)NCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](CCl)CCCNCc1ccccc1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(=O)NCc1ccccc1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](CCl)CCCNCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]5(C)C4=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(=O)NCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@@H]1C=C(CNCc2ccccc2)N=N1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(=O)NCc1ccccc1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@@H]1C=C(CNCc2ccccc2)N=N1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&C=C(C&)N=N1",
"old_substring": "[C@@H]5(C)C4=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(=O)NCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@]1(C)CCCN(NCc2ccccc2)C1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(=O)NCc1ccccc1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@]1(C)CCCN(NCc2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@]1&(C)CCCN&C1",
"old_substring": "[C@@H]5(C)C4=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(=O)NCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@@H](CBr)CCNCc1ccccc1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)C(=O)NCc1ccccc1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@@H](CBr)CCNCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@@H]5(C)C4=O"
}
|
Can you make molecule CC(=O)N(C)c1cccc(Nc2cc(C)nc3ncnn23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)N1CCN=C1Sc1cccc(Nc2cc(C)nc3ncnn23)c1
|
CC(=O)N(C)c1cccc(Nc2cc(C)nc3ncnn23)c1
|
CC(=O)N1CCN=C1Sc1cccc(Nc2cc(C)nc3ncnn23)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N46C"
}
|
Can you make molecule CC(=O)N(C)c1cccc(Nc2cc(C)nc3ncnn23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)c1nc(C#N)c(-c2cccc(Nc3cc(C)nc4ncnn34)c2)o1
|
CC(=O)N(C)c1cccc(Nc2cc(C)nc3ncnn23)c1
|
CC(=O)c1nc(C#N)c(-c2cccc(Nc3cc(C)nc4ncnn34)c2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1nc&oc1&",
"old_substring": "N46C"
}
|
Can you make molecule CC(=O)N(C)c1cccc(Nc2cc(C)nc3ncnn23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)c1cc(C#N)c(-c2cccc(Nc3cc(C)nc4ncnn34)c2)s1
|
CC(=O)N(C)c1cccc(Nc2cc(C)nc3ncnn23)c1
|
CC(=O)c1cc(C#N)c(-c2cccc(Nc3cc(C)nc4ncnn34)c2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N46C"
}
|
Can you make molecule CC(=O)N(C)c1cccc(Nc2cc(C)nc3ncnn23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)c1ccc(-c2cccc(Nc3cc(C)nc4ncnn34)c2)c(C#N)c1
|
CC(=O)N(C)c1cccc(Nc2cc(C)nc3ncnn23)c1
|
CC(=O)c1ccc(-c2cccc(Nc3cc(C)nc4ncnn34)c2)c(C#N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N46C"
}
|
Can you make molecule CC(=O)N(C)c1cccc(Nc2cc(C)nc3ncnn23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)ON=C1CCN(c2cccc(Nc3cc(C)nc4ncnn34)c2)CC1
|
CC(=O)N(C)c1cccc(Nc2cc(C)nc3ncnn23)c1
|
CC(=O)ON=C1CCN(c2cccc(Nc3cc(C)nc4ncnn34)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "N46C"
}
|
Can you make molecule CC(C)OCc1cccc(N[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)OCc1cccc(-c2snc([C@H](C)C(=O)NC(=O)NC(C)(C)C)c2N)c1
|
CC(C)OCc1cccc(N[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1
|
CC(C)OCc1cccc(-c2snc([C@H](C)C(=O)NC(=O)NC(C)(C)C)c2N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&nsc1&",
"old_substring": "N79"
}
|
Can you make molecule CC(C)OCc1cccc(N[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)OCc1cccc(SC(=S)N(C)[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1
|
CC(C)OCc1cccc(N[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1
|
CC(C)OCc1cccc(SC(=S)N(C)[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N79"
}
|
Can you make molecule CC(C)OCc1cccc(N[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)OCc1cccc(-c2cc([C@H](C)C(=O)NC(=O)NC(C)(C)C)oc2N)c1
|
CC(C)OCc1cccc(N[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1
|
CC(C)OCc1cccc(-c2cc([C@H](C)C(=O)NC(=O)NC(C)(C)C)oc2N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1oc&cc1&",
"old_substring": "N79"
}
|
Can you make molecule CC(C)OCc1cccc(N[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)OCc1cccc(SC2=NCCN2[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1
|
CC(C)OCc1cccc(N[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1
|
CC(C)OCc1cccc(SC2=NCCN2[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N79"
}
|
Can you make molecule CC(C)OCc1cccc(N[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)OCc1cccc(C2CCN(C[C@H](C)C(=O)NC(=O)NC(C)(C)C)CC2)c1
|
CC(C)OCc1cccc(N[C@H](C)C(=O)NC(=O)NC(C)(C)C)c1
|
CC(C)OCc1cccc(C2CCN(C[C@H](C)C(=O)NC(=O)NC(C)(C)C)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N79"
}
|
Can you make molecule CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN1CCN(C)C1=NSC(=O)[C@@]12CC[C@@](C)(c3nc4cc5c(cc4nc31)OCO5)C2(C)C
|
CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1
|
CN1CCN(C)C1=NSC(=O)[C@@]12CC[C@@](C)(c3nc4cc5c(cc4nc31)OCO5)C2(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CN1CCN(C)C1=NS&",
"old_substring": "CN1CCN7CC1"
}
|
Can you make molecule CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN1CCC[C@H]1C(=O)[C@@]12CC[C@@](C)(c3nc4cc5c(cc4nc31)OCO5)C2(C)C
|
CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1
|
CN1CCC[C@H]1C(=O)[C@@]12CC[C@@](C)(c3nc4cc5c(cc4nc31)OCO5)C2(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CN1CCC[C@H]1&",
"old_substring": "CN1CCN7CC1"
}
|
Can you make molecule CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)[C@@]2(C)CC[C@]1(C(=O)CNN1CCCCC1)c1nc3cc4c(cc3nc12)OCO4
|
CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1
|
CC1(C)[C@@]2(C)CC[C@]1(C(=O)CNN1CCCCC1)c1nc3cc4c(cc3nc12)OCO4
| 102
|
{
"fragment_index": 0,
"new_substring": "C&NN1CCCCC1",
"old_substring": "CN1CCN7CC1"
}
|
Can you make molecule CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)[C@@]2(C)CC[C@]1(C(=O)CN1CCSCC1)c1nc3cc4c(cc3nc12)OCO4
|
CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1
|
CC1(C)[C@@]2(C)CC[C@]1(C(=O)CN1CCSCC1)c1nc3cc4c(cc3nc12)OCO4
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCSCC1",
"old_substring": "CN1CCN7CC1"
}
|
Can you make molecule CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)[C@@]2(C)CC[C@]1(C(=O)CN1CCCCC1)c1nc3cc4c(cc3nc12)OCO4
|
CN1CCN(C(=O)[C@@]23CC[C@@](C)(c4nc5cc6c(cc5nc42)OCO6)C3(C)C)CC1
|
CC1(C)[C@@]2(C)CC[C@]1(C(=O)CN1CCCCC1)c1nc3cc4c(cc3nc12)OCO4
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCCCC1",
"old_substring": "CN1CCN7CC1"
}
|
Can you make molecule CC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CS[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21
|
CC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21
|
C=CS[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC3"
}
|
Can you make molecule CC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21
|
CC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21
|
C=CCC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+](CCCCl)CC(=O)NN1c2ccccc2CCc2ccccc21
|
CC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21
|
CC[NH+](CCCCl)CC(=O)NN1c2ccccc2CCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+](CCCCS)CC(=O)NN1c2ccccc2CCc2ccccc21
|
CC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21
|
CC[NH+](CCCCS)CC(=O)NN1c2ccccc2CCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule CC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+](CCCBr)CC(=O)NN1c2ccccc2CCc2ccccc21
|
CC[NH+](CC)CC(=O)NN1c2ccccc2CCc2ccccc21
|
CC[NH+](CCCBr)CC(=O)NN1c2ccccc2CCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC3"
}
|
Can you make molecule Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(C)c1CCCNSC(=O)Cc1c(Cl)ccc(Cl)c1Cl
|
Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl
|
Cc1noc(C)c1CCCNSC(=O)Cc1c(Cl)ccc(Cl)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(C)c1CCCNC(=O)CCCC(=O)c1c(Cl)ccc(Cl)c1Cl
|
Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl
|
Cc1noc(C)c1CCCNC(=O)CCCC(=O)c1c(Cl)ccc(Cl)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C24=O"
}
|
Can you make molecule Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(C)c1CCCNC(=O)CC(C)(C)c1c(Cl)ccc(Cl)c1Cl
|
Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl
|
Cc1noc(C)c1CCCNC(=O)CC(C)(C)c1c(Cl)ccc(Cl)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(C)c1CCCNC(=O)CCC(C)(C)c1c(Cl)ccc(Cl)c1Cl
|
Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl
|
Cc1noc(C)c1CCCNC(=O)CCC(C)(C)c1c(Cl)ccc(Cl)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(C)c1CCCNSC(=O)[C@@H](C)c1c(Cl)ccc(Cl)c1Cl
|
Cc1noc(C)c1CCCNC(=O)c1c(Cl)ccc(Cl)c1Cl
|
Cc1noc(C)c1CCCNSC(=O)[C@@H](C)c1c(Cl)ccc(Cl)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C24=O"
}
|
Can you make molecule Oc1ccc(C[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br less soluble in water? The output molecule should be similar to the input molecule.
|
Oc1ccc(CCCC[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
|
Oc1ccc(C[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
|
Oc1ccc(CCCC[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C36"
}
|
Can you make molecule Oc1ccc(C[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br less soluble in water? The output molecule should be similar to the input molecule.
|
Oc1ccc(CCCCC[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
|
Oc1ccc(C[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
|
Oc1ccc(CCCCC[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C36"
}
|
Can you make molecule Oc1ccc(C[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br less soluble in water? The output molecule should be similar to the input molecule.
|
Oc1ccc(C2CC([NH2+][C@H]3CCCC[C@@H]3C(F)(F)F)C2)cc1Br
|
Oc1ccc(C[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
|
Oc1ccc(C2CC([NH2+][C@H]3CCCC[C@@H]3C(F)(F)F)C2)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C36"
}
|
Can you make molecule Oc1ccc(C[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br less soluble in water? The output molecule should be similar to the input molecule.
|
Oc1ccc(SC(=S)O[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
|
Oc1ccc(C[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
|
Oc1ccc(SC(=S)O[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C36"
}
|
Can you make molecule Oc1ccc(C[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br less soluble in water? The output molecule should be similar to the input molecule.
|
Oc1ccc(NC(=S)S[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
|
Oc1ccc(C[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
|
Oc1ccc(NC(=S)S[NH2+][C@H]2CCCC[C@@H]2C(F)(F)F)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C36"
}
|
Can you make molecule Cc1cc2nc(N(Cc3ccncc3)C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2nc(C3(Cc4ccncc4)CCN(C(=O)c4ccc(S(=O)(=O)C(C)C)cc4)C3)sc2cc1C
|
Cc1cc2nc(N(Cc3ccncc3)C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C
|
Cc1cc2nc(C3(Cc4ccncc4)CCN(C(=O)c4ccc(S(=O)(=O)C(C)C)cc4)C3)sc2cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N456"
}
|
Can you make molecule Cc1cc2nc(N(Cc3ccncc3)C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2nc(C3(Cc4ccncc4)CCCN(C(=O)c4ccc(S(=O)(=O)C(C)C)cc4)C3)sc2cc1C
|
Cc1cc2nc(N(Cc3ccncc3)C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C
|
Cc1cc2nc(C3(Cc4ccncc4)CCCN(C(=O)c4ccc(S(=O)(=O)C(C)C)cc4)C3)sc2cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N456"
}
|
Can you make molecule Cc1cc2nc(N(Cc3ccncc3)C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2nc(-c3c(Cc4ccncc4)oc(C(=O)c4ccc(S(=O)(=O)C(C)C)cc4)c3C#N)sc2cc1C
|
Cc1cc2nc(N(Cc3ccncc3)C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C
|
Cc1cc2nc(-c3c(Cc4ccncc4)oc(C(=O)c4ccc(S(=O)(=O)C(C)C)cc4)c3C#N)sc2cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N456"
}
|
Can you make molecule Cc1cc2nc(N(Cc3ccncc3)C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2nc([C@]3(Cc4ccncc4)CCCN(C(=O)c4ccc(S(=O)(=O)C(C)C)cc4)C3)sc2cc1C
|
Cc1cc2nc(N(Cc3ccncc3)C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C
|
Cc1cc2nc([C@]3(Cc4ccncc4)CCCN(C(=O)c4ccc(S(=O)(=O)C(C)C)cc4)C3)sc2cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC[C@@]&&C1",
"old_substring": "N456"
}
|
Can you make molecule Cc1cc2nc(N(Cc3ccncc3)C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc2nc([C@H]3N(Cc4ccncc4)CCCN3C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C
|
Cc1cc2nc(N(Cc3ccncc3)C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C
|
Cc1cc2nc([C@H]3N(Cc4ccncc4)CCCN3C(=O)c3ccc(S(=O)(=O)C(C)C)cc3)sc2cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCN&[C@@H]1&",
"old_substring": "N456"
}
|
Can you make molecule Cc1cc(NC(=O)[C@@H](C)c2cccs2)cnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)[C@@H](C)c2ccc(Cl)s2)cnc1Cl
|
Cc1cc(NC(=O)[C@@H](C)c2cccs2)cnc1Cl
|
Cc1cc(NC(=O)[C@@H](C)c2ccc(Cl)s2)cnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)s1",
"old_substring": "c15cccs1"
}
|
Can you make molecule Cc1cc(NC(=O)[C@@H](C)c2cccs2)cnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)[C@@H](C)c2ccc(Br)s2)cnc1Cl
|
Cc1cc(NC(=O)[C@@H](C)c2cccs2)cnc1Cl
|
Cc1cc(NC(=O)[C@@H](C)c2ccc(Br)s2)cnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)s1",
"old_substring": "c15cccs1"
}
|
Can you make molecule Cc1cc(NC(=O)[C@@H](C)c2cccs2)cnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)[C@@H](C)c2sccc2Br)cnc1Cl
|
Cc1cc(NC(=O)[C@@H](C)c2cccs2)cnc1Cl
|
Cc1cc(NC(=O)[C@@H](C)c2sccc2Br)cnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sccc1Br",
"old_substring": "c15cccs1"
}
|
Can you make molecule Cc1cc(NC(=O)[C@@H](C)c2cccs2)cnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)[C@@H](C)c2csc(I)c2)cnc1Cl
|
Cc1cc(NC(=O)[C@@H](C)c2cccs2)cnc1Cl
|
Cc1cc(NC(=O)[C@@H](C)c2csc(I)c2)cnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&csc(I)c1",
"old_substring": "c15cccs1"
}
|
Can you make molecule Cc1cc(NC(=O)[C@@H](C)c2cccs2)cnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)[C@@H](C)c2cc3c(s2)CSC3)cnc1Cl
|
Cc1cc(NC(=O)[C@@H](C)c2cccs2)cnc1Cl
|
Cc1cc(NC(=O)[C@@H](C)c2cc3c(s2)CSC3)cnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2c(s1)CSC2",
"old_substring": "c15cccs1"
}
|
Can you make molecule CC(C)CNC(=O)[C@H](C)[NH+]1CCCN(CC[NH3+])CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[NH+]1CCC(C)(N2CCC[NH+]([C@@H](C)C(N)=O)CC2)CC1
|
CC(C)CNC(=O)[C@H](C)[NH+]1CCCN(CC[NH3+])CC1
|
CC(C)C[NH+]1CCC(C)(N2CCC[NH+]([C@@H](C)C(N)=O)CC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CC[NH+]&CC1",
"old_substring": "C5C[NH3+]"
}
|
Can you make molecule CC(C)CNC(=O)[C@H](C)[NH+]1CCCN(CC[NH3+])CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@@H](CCN1CCC[NH+]([C@@H](C)C(N)=O)CC1)NN
|
CC(C)CNC(=O)[C@H](C)[NH+]1CCCN(CC[NH3+])CC1
|
CC(C)C[C@@H](CCN1CCC[NH+]([C@@H](C)C(N)=O)CC1)NN
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C[C@H]&NN",
"old_substring": "C5C[NH3+]"
}
|
Can you make molecule CC(C)CNC(=O)[C@H](C)[NH+]1CCCN(CC[NH3+])CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[NH+](CN)Cc1c2cccc1N1CCC[NH+](CC1)[C@@H](C)C2=O
|
CC(C)CNC(=O)[C@H](C)[NH+]1CCCN(CC[NH3+])CC1
|
CC(C)C[NH+](CN)Cc1c2cccc1N1CCC[NH+](CC1)[C@@H](C)C2=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc2c1C[NH+]&C2",
"old_substring": "C5C[NH3+]"
}
|
Can you make molecule CC(C)CNC(=O)[C@H](C)[NH+]1CCCN(CC[NH3+])CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CCCC(C)C)N1CCC[NH+]([C@@H](C)C(N)=O)CC1
|
CC(C)CNC(=O)[C@H](C)[NH+]1CCCN(CC[NH3+])CC1
|
CCC[C@@H](CCCC(C)C)N1CCC[NH+]([C@@H](C)C(N)=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&",
"old_substring": "C5C[NH3+]"
}
|
Can you make molecule CC(C)CNC(=O)[C@H](C)[NH+]1CCCN(CC[NH3+])CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@@H](Cl)CCN1CCC[NH+]([C@@H](C)C(N)=O)CC1
|
CC(C)CNC(=O)[C@H](C)[NH+]1CCCN(CC[NH3+])CC1
|
CC(C)C[C@@H](Cl)CCN1CCC[NH+]([C@@H](C)C(N)=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C[C@@H]&Cl",
"old_substring": "C5C[NH3+]"
}
|
Can you make molecule CCOCC[NH2+]Cc1c(C)nn(C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(O)c(CC[NH2+]Cc2c(C)nn(C)c2C)c2onc1-2
|
CCOCC[NH2+]Cc1c(C)nn(C)c1C
|
CCc1ccc(O)c(CC[NH2+]Cc2c(C)nn(C)c2C)c2onc1-2
| 102
|
{
"fragment_index": 0,
"new_substring": "Oc1ccc2c&noc2c1&",
"old_substring": "O23"
}
|
Can you make molecule CCOCC[NH2+]Cc1c(C)nn(C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCOc2ccc(CC[NH2+]Cc3c(C)nn(C)c3C)cc2C1
|
CCOCC[NH2+]Cc1c(C)nn(C)c1C
|
CCN1CCOc2ccc(CC[NH2+]Cc3c(C)nn(C)c3C)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1",
"old_substring": "O23"
}
|
Can you make molecule CCOCC[NH2+]Cc1c(C)nn(C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc2ccc-2ncn(CC[NH2+]Cc2c(C)nn(C)c2C)c1=O
|
CCOCC[NH2+]Cc1c(C)nn(C)c1C
|
CCc1cc2ccc-2ncn(CC[NH2+]Cc2c(C)nn(C)c2C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cc&ccc2ncn1&",
"old_substring": "O23"
}
|
Can you make molecule CCOCC[NH2+]Cc1c(C)nn(C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc2nc-2ccn(CC[NH2+]Cc2c(C)nn(C)c2C)c1=O
|
CCOCC[NH2+]Cc1c(C)nn(C)c1C
|
CCc1ccc2nc-2ccn(CC[NH2+]Cc2c(C)nn(C)c2C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2ccc&nc2ccn1&",
"old_substring": "O23"
}
|
Can you make molecule CCOCC[NH2+]Cc1c(C)nn(C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cnc2nc-2ccn(CC[NH2+]Cc2c(C)nn(C)c2C)c1=O
|
CCOCC[NH2+]Cc1c(C)nn(C)c1C
|
CCc1cnc2nc-2ccn(CC[NH2+]Cc2c(C)nn(C)c2C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cnc&nc2ccn1&",
"old_substring": "O23"
}
|
Can you make molecule CCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C
|
CCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C
|
C=CSOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC4"
}
|
Can you make molecule CCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C
|
CCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C
|
C=CCCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC4"
}
|
Can you make molecule CCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCS(=O)(=O)c1ccccc1C(=O)/N=c1/sc(C(=O)OCCCCl)c(C)n1C
|
CCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C
|
CCS(=O)(=O)c1ccccc1C(=O)/N=c1/sc(C(=O)OCCCCl)c(C)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC4"
}
|
Can you make molecule CCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCS(=O)(=O)c1ccccc1C(=O)/N=c1/sc(C(=O)OCCCCS)c(C)n1C
|
CCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C
|
CCS(=O)(=O)c1ccccc1C(=O)/N=c1/sc(C(=O)OCCCCS)c(C)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC4"
}
|
Can you make molecule CCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCS(=O)(=O)c1ccccc1C(=O)/N=c1/sc(C(=O)OCCCBr)c(C)n1C
|
CCOC(=O)c1s/c(=N/C(=O)c2ccccc2S(=O)(=O)CC)n(C)c1C
|
CCS(=O)(=O)c1ccccc1C(=O)/N=c1/sc(C(=O)OCCCBr)c(C)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC4"
}
|
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