prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CC1CCC(C[NH3+])(NC(=O)N[C@H]2CCOC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCC(N)(CC2=CCC[NH+](C(=O)N[C@H]3CCOC3)C2)CC1
|
CC1CCC(C[NH3+])(NC(=O)N[C@H]2CCOC2)CC1
|
CC1CCC(N)(CC2=CCC[NH+](C(=O)N[C@H]3CCOC3)C2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C1=CCC[NH+]&C1",
"old_substring": "C7[NH3+]"
}
|
Can you make molecule CC1CCC(C[NH3+])(NC(=O)N[C@H]2CCOC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CCC(N)(C2(C)CC[NH+](C(=O)N[C@H]3CCOC3)CC2)CC1
|
CC1CCC(C[NH3+])(NC(=O)N[C@H]2CCOC2)CC1
|
CC1CCC(N)(C2(C)CC[NH+](C(=O)N[C@H]3CCOC3)CC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CC[NH+]&CC1",
"old_substring": "C7[NH3+]"
}
|
Can you make molecule CC1CCC(C[NH3+])(NC(=O)N[C@H]2CCOC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C2(N)CCC(C)CC2)[nH+]cn1C(=O)N[C@H]1CCOC1
|
CC1CCC(C[NH3+])(NC(=O)N[C@H]2CCOC2)CC1
|
Cc1c(C2(N)CCC(C)CC2)[nH+]cn1C(=O)N[C@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&[nH+]cn1&",
"old_substring": "C7[NH3+]"
}
|
Can you make molecule CC1CCC(C[NH3+])(NC(=O)N[C@H]2CCOC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c[nH+]c(C2(N)CCC(C)CC2)nc1C(=O)N[C@H]1CCOC1
|
CC1CCC(C[NH3+])(NC(=O)N[C@H]2CCOC2)CC1
|
Cc1c[nH+]c(C2(N)CCC(C)CC2)nc1C(=O)N[C@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c[nH+]c&nc1&",
"old_substring": "C7[NH3+]"
}
|
Can you make molecule CC1CCC(C[NH3+])(NC(=O)N[C@H]2CCOC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1[nH+]c(C2(N)CCC(C)CC2)ccc1C(=O)N[C@H]1CCOC1
|
CC1CCC(C[NH3+])(NC(=O)N[C@H]2CCOC2)CC1
|
Cc1[nH+]c(C2(N)CCC(C)CC2)ccc1C(=O)N[C@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1[nH+]c&ccc1&",
"old_substring": "C7[NH3+]"
}
|
Can you make molecule COC[C@H](O)CCCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=C[C@H](O)CCCC(F)(F)F)c1cccs1
|
COC[C@H](O)CCCC(F)(F)F
|
COC(=C[C@H](O)CCCC(F)(F)F)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC=&c1cccs1",
"old_substring": "CO1"
}
|
Can you make molecule COC[C@H](O)CCCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=C[C@H](O)CCCC(F)(F)F)c1ccccc1
|
COC[C@H](O)CCCC(F)(F)F
|
COC(=C[C@H](O)CCCC(F)(F)F)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC=&c1ccccc1",
"old_substring": "CO1"
}
|
Can you make molecule COC[C@H](O)CCCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
OC(=C[C@H](O)CCCC(F)(F)F)c1cccs1
|
COC[C@H](O)CCCC(F)(F)F
|
OC(=C[C@H](O)CCCC(F)(F)F)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(O)c1cccs1",
"old_substring": "CO1"
}
|
Can you make molecule COC[C@H](O)CCCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
OC(=C[C@H](O)CCCC(F)(F)F)c1ccco1
|
COC[C@H](O)CCCC(F)(F)F
|
OC(=C[C@H](O)CCCC(F)(F)F)c1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(O)c1ccco1",
"old_substring": "CO1"
}
|
Can you make molecule COC[C@H](O)CCCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C[C@H](O)CCCC(F)(F)F)C1=CCC1
|
COC[C@H](O)CCCC(F)(F)F
|
O=C(C[C@H](O)CCCC(F)(F)F)C1=CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C1=CCC1",
"old_substring": "CO1"
}
|
Can you make molecule COc1ccc(CCNC(=O)[C@@]23CC[C@@](C)(c4nc5ccc([N+](=O)[O-])cc5nc42)C3(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC(=O)[C@@]12CC[C@@](C)(c3nc4ccc([N+](=O)[O-])cc4nc31)C2(C)C.CO.COc1ccccc1
|
COc1ccc(CCNC(=O)[C@@]23CC[C@@](C)(c4nc5ccc([N+](=O)[O-])cc5nc42)C3(C)C)cc1OC
|
CCNC(=O)[C@@]12CC[C@@](C)(c3nc4ccc([N+](=O)[O-])cc4nc31)C2(C)C.CO.COc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1&",
"old_substring": "c17ccc%11cc18"
}
|
Can you make molecule COc1ccc(CCNC(=O)[C@@]23CC[C@@](C)(c4nc5ccc([N+](=O)[O-])cc5nc42)C3(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC(=O)[C@@]12CC[C@@](C)(c3nc4ccc([N+](=O)[O-])cc4nc31)C2(C)C.CO.COc1ccccc1I
|
COc1ccc(CCNC(=O)[C@@]23CC[C@@](C)(c4nc5ccc([N+](=O)[O-])cc5nc42)C3(C)C)cc1OC
|
CCNC(=O)[C@@]12CC[C@@](C)(c3nc4ccc([N+](=O)[O-])cc4nc31)C2(C)C.CO.COc1ccccc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1I",
"old_substring": "c17ccc%11cc18"
}
|
Can you make molecule COc1ccc(CCNC(=O)[C@@]23CC[C@@](C)(c4nc5ccc([N+](=O)[O-])cc5nc42)C3(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC(=O)[C@@]12CC[C@@](C)(c3nc4ccc([N+](=O)[O-])cc4nc31)C2(C)C.CO.COc1ccccc1Cl
|
COc1ccc(CCNC(=O)[C@@]23CC[C@@](C)(c4nc5ccc([N+](=O)[O-])cc5nc42)C3(C)C)cc1OC
|
CCNC(=O)[C@@]12CC[C@@](C)(c3nc4ccc([N+](=O)[O-])cc4nc31)C2(C)C.CO.COc1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1Cl",
"old_substring": "c17ccc%11cc18"
}
|
Can you make molecule COc1ccc(CCNC(=O)[C@@]23CC[C@@](C)(c4nc5ccc([N+](=O)[O-])cc5nc42)C3(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC(=O)[C@@]12CC[C@@](C)(c3nc4ccc([N+](=O)[O-])cc4nc31)C2(C)C.CO.COc1ccc2cccnc2c1
|
COc1ccc(CCNC(=O)[C@@]23CC[C@@](C)(c4nc5ccc([N+](=O)[O-])cc5nc42)C3(C)C)cc1OC
|
CCNC(=O)[C@@]12CC[C@@](C)(c3nc4ccc([N+](=O)[O-])cc4nc31)C2(C)C.CO.COc1ccc2cccnc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc2c&cc&nc2c1",
"old_substring": "c17ccc%11cc18"
}
|
Can you make molecule COc1ccc(CCNC(=O)[C@@]23CC[C@@](C)(c4nc5ccc([N+](=O)[O-])cc5nc42)C3(C)C)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCNC(=O)[C@@]12CC[C@@](C)(c3nc4ccc([N+](=O)[O-])cc4nc31)C2(C)C.CO.COc1cccc(I)c1
|
COc1ccc(CCNC(=O)[C@@]23CC[C@@](C)(c4nc5ccc([N+](=O)[O-])cc5nc42)C3(C)C)cc1OC
|
CCNC(=O)[C@@]12CC[C@@](C)(c3nc4ccc([N+](=O)[O-])cc4nc31)C2(C)C.CO.COc1cccc(I)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&cc(I)c1&",
"old_substring": "c17ccc%11cc18"
}
|
Can you make molecule CC(C)c1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1c(=O)c2nnc(CCCCBr)n2c2ccccc21)Nc1ccc(Br)cc1F
|
CC(C)c1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12
|
O=C(Cn1c(=O)c2nnc(CCCCBr)n2c2ccccc21)Nc1ccc(Br)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CC7C"
}
|
Can you make molecule CC(C)c1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCc1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12
|
CC(C)c1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12
|
C=CCCCCc1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CC7C"
}
|
Can you make molecule CC(C)c1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1c(=O)c2nnc(CCCCCBr)n2c2ccccc21)Nc1ccc(Br)cc1F
|
CC(C)c1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12
|
O=C(Cn1c(=O)c2nnc(CCCCCBr)n2c2ccccc21)Nc1ccc(Br)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCBr",
"old_substring": "CC7C"
}
|
Can you make molecule CC(C)c1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1c(=O)c2nnc(CCCCCS)n2c2ccccc21)Nc1ccc(Br)cc1F
|
CC(C)c1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12
|
O=C(Cn1c(=O)c2nnc(CCCCCS)n2c2ccccc21)Nc1ccc(Br)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "SCCCCC&",
"old_substring": "CC7C"
}
|
Can you make molecule CC(C)c1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1c(=O)c2nnc(CCCCCCS)n2c2ccccc21)Nc1ccc(Br)cc1F
|
CC(C)c1nnc2c(=O)n(CC(=O)Nc3ccc(Br)cc3F)c3ccccc3n12
|
O=C(Cn1c(=O)c2nnc(CCCCCCS)n2c2ccccc21)Nc1ccc(Br)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "SCCCCCC&",
"old_substring": "CC7C"
}
|
Can you make molecule C[NH+](Cc1csc(-c2ccccc2)n1)C[C@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
c1ccc(-c2nc(CC[NH+]3CCC(C[C@H]4CCOC4)CC3)cs2)cc1
|
C[NH+](Cc1csc(-c2ccccc2)n1)C[C@H]1CCOC1
|
c1ccc(-c2nc(CC[NH+]3CCC(C[C@H]4CCOC4)CC3)cs2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&CC1",
"old_substring": "C[NH+]34"
}
|
Can you make molecule C[NH+](Cc1csc(-c2ccccc2)n1)C[C@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C1=C(CCc2csc(-c3ccccc3)n2)C[NH+](C[C@H]2CCOC2)CC1
|
C[NH+](Cc1csc(-c2ccccc2)n1)C[C@H]1CCOC1
|
C1=C(CCc2csc(-c3ccccc3)n2)C[NH+](C[C@H]2CCOC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C1=CCC[NH+]&C1",
"old_substring": "C[NH+]34"
}
|
Can you make molecule C[NH+](Cc1csc(-c2ccccc2)n1)C[C@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(Cc2csc(-c3ccccc3)n2)CC[NH+](C[C@H]2CCOC2)CC1
|
C[NH+](Cc1csc(-c2ccccc2)n1)C[C@H]1CCOC1
|
CC1(Cc2csc(-c3ccccc3)n2)CC[NH+](C[C@H]2CCOC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CC[NH+]&CC1",
"old_substring": "C[NH+]34"
}
|
Can you make molecule C[NH+](Cc1csc(-c2ccccc2)n1)C[C@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C[C@H]2CCOC2)CC[NH+](CCc2csc(-c3ccccc3)n2)CC1
|
C[NH+](Cc1csc(-c2ccccc2)n1)C[C@H]1CCOC1
|
CC1(C[C@H]2CCOC2)CC[NH+](CCc2csc(-c3ccccc3)n2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&(C)CC1",
"old_substring": "C[NH+]34"
}
|
Can you make molecule C[NH+](Cc1csc(-c2ccccc2)n1)C[C@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
c1ccc(-c2nc(CC[NH+]3CC[C@@H](C[C@H]4CCOC4)C3)cs2)cc1
|
C[NH+](Cc1csc(-c2ccccc2)n1)C[C@H]1CCOC1
|
c1ccc(-c2nc(CC[NH+]3CC[C@@H](C[C@H]4CCOC4)C3)cs2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CC[C@@H]&C1",
"old_substring": "C[NH+]34"
}
|
Can you make molecule C[C@H](CCCO)NC(=O)C[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CCCO)NSC(=O)C[C@H]1CCS(=O)(=O)C1
|
C[C@H](CCCO)NC(=O)C[C@H]1CCS(=O)(=O)C1
|
C[C@H](CCCO)NSC(=O)C[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule C[C@H](CCCO)NC(=O)C[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CCCO)NC(=O)CC(C)(C)[C@H]1CCS(=O)(=O)C1
|
C[C@H](CCCO)NC(=O)C[C@H]1CCS(=O)(=O)C1
|
C[C@H](CCCO)NC(=O)CC(C)(C)[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule C[C@H](CCCO)NC(=O)C[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CCCO)NC[S@+]([O-])CCC[C@H]1CCS(=O)(=O)C1
|
C[C@H](CCCO)NC(=O)C[C@H]1CCS(=O)(=O)C1
|
C[C@H](CCCO)NC[S@+]([O-])CCC[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule C[C@H](CCCO)NC(=O)C[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CCCO)NC(=O)CCC(C)(C)[C@H]1CCS(=O)(=O)C1
|
C[C@H](CCCO)NC(=O)C[C@H]1CCS(=O)(=O)C1
|
C[C@H](CCCO)NC(=O)CCC(C)(C)[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule C[C@H](CCCO)NC(=O)C[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CCCO)NC(=O)C[C@H](C)[C@H]1CCS(=O)(=O)C1
|
C[C@H](CCCO)NC(=O)C[C@H]1CCS(=O)(=O)C1
|
C[C@H](CCCO)NC(=O)C[C@H](C)[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@@H]&C",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule Cn1cc(C(=O)N2C[C@@H](c3ccccc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C(=O)N2C[C@@H](c3cc(C(F)F)[nH]n3)[C@H](c3ccccc3Cl)C2)ccc1=O
|
Cn1cc(C(=O)N2C[C@@H](c3ccccc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O
|
Cn1cc(C(=O)N2C[C@@H](c3cc(C(F)F)[nH]n3)[C@H](c3ccccc3Cl)C2)ccc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c18ccccc1"
}
|
Can you make molecule Cn1cc(C(=O)N2C[C@@H](c3ccccc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C(=O)N2C[C@@H](c3ccc(I)cc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O
|
Cn1cc(C(=O)N2C[C@@H](c3ccccc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O
|
Cn1cc(C(=O)N2C[C@@H](c3ccc(I)cc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c18ccccc1"
}
|
Can you make molecule Cn1cc(C(=O)N2C[C@@H](c3ccccc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H]2CN(C(=O)c3ccc(=O)n(C)c3)C[C@H]2c2cc(C(F)F)[nH]n2)cc1I
|
Cn1cc(C(=O)N2C[C@@H](c3ccccc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O
|
Cc1ccc([C@@H]2CN(C(=O)c3ccc(=O)n(C)c3)C[C@H]2c2cc(C(F)F)[nH]n2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c18ccccc1"
}
|
Can you make molecule Cn1cc(C(=O)N2C[C@@H](c3ccccc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C(=O)N2C[C@@H](c3cccc(Br)c3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O
|
Cn1cc(C(=O)N2C[C@@H](c3ccccc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O
|
Cn1cc(C(=O)N2C[C@@H](c3cccc(Br)c3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c18ccccc1"
}
|
Can you make molecule Cn1cc(C(=O)N2C[C@@H](c3ccccc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@@H]2CN(C(=O)c3ccc(=O)n(C)c3)C[C@H]2c2cc(C(F)F)[nH]n2)c1C
|
Cn1cc(C(=O)N2C[C@@H](c3ccccc3)[C@H](c3cc(C(F)F)[nH]n3)C2)ccc1=O
|
Cc1cccc([C@@H]2CN(C(=O)c3ccc(=O)n(C)c3)C[C@H]2c2cc(C(F)F)[nH]n2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c18ccccc1"
}
|
Can you make molecule Cc1ncsc1CNc1ccccc1OCC(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1CCCCNc1ccccc1OCC(F)F
|
Cc1ncsc1CNc1ccccc1OCC(F)F
|
Cc1ncsc1CCCCNc1ccccc1OCC(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C46"
}
|
Can you make molecule Cc1ncsc1CNc1ccccc1OCC(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1CCC=Nc1ccccc1OCC(F)F
|
Cc1ncsc1CNc1ccccc1OCC(F)F
|
Cc1ncsc1CCC=Nc1ccccc1OCC(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC&",
"old_substring": "C46"
}
|
Can you make molecule Cc1ncsc1CNc1ccccc1OCC(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1CCCCCNc1ccccc1OCC(F)F
|
Cc1ncsc1CNc1ccccc1OCC(F)F
|
Cc1ncsc1CCCCCNc1ccccc1OCC(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C46"
}
|
Can you make molecule Cc1ncsc1CNc1ccccc1OCC(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1C1CC(Nc2ccccc2OCC(F)F)C1
|
Cc1ncsc1CNc1ccccc1OCC(F)F
|
Cc1ncsc1C1CC(Nc2ccccc2OCC(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C46"
}
|
Can you make molecule Cc1ncsc1CNc1ccccc1OCC(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1SC(=S)ONc1ccccc1OCC(F)F
|
Cc1ncsc1CNc1ccccc1OCC(F)F
|
Cc1ncsc1SC(=S)ONc1ccccc1OCC(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C46"
}
|
Can you make molecule CC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
|
CC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
|
CCCC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&=O",
"old_substring": "CC5=O"
}
|
Can you make molecule CC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
|
CC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
|
CCCCC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CC5=O"
}
|
Can you make molecule CC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)CCCc1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
|
CC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
|
CC(=O)CCCc1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)CCC&",
"old_substring": "CC5=O"
}
|
Can you make molecule CC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)CCCc1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
|
CC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
|
CCC(=O)CCCc1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(=O)CCC&",
"old_substring": "CC5=O"
}
|
Can you make molecule CC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)Cc1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
|
CC(=O)c1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
|
CCCCC(=O)Cc1ccccc1OCCCCN1C[C@H](C)O[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC(=O)C&",
"old_substring": "CC5=O"
}
|
Can you make molecule O=C([O-])c1cc(-c2cccc(C(F)(F)F)c2)nc2c(F)cccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1cc(-c2cccc(SC(F)(F)F)c2)nc2c(F)cccc12
|
O=C([O-])c1cc(-c2cccc(C(F)(F)F)c2)nc2c(F)cccc12
|
O=C([O-])c1cc(-c2cccc(SC(F)(F)F)c2)nc2c(F)cccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C4(F)(F)F"
}
|
Can you make molecule O=C([O-])c1cc(-c2cccc(C(F)(F)F)c2)nc2c(F)cccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1cc(-c2cccc(CCCC(F)(F)F)c2)nc2c(F)cccc12
|
O=C([O-])c1cc(-c2cccc(C(F)(F)F)c2)nc2c(F)cccc12
|
O=C([O-])c1cc(-c2cccc(CCCC(F)(F)F)c2)nc2c(F)cccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C4(F)(F)F"
}
|
Can you make molecule O=C([O-])c1cc(-c2cccc(C(F)(F)F)c2)nc2c(F)cccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1cc(-c2cccc(CCCCC(F)(F)F)c2)nc2c(F)cccc12
|
O=C([O-])c1cc(-c2cccc(C(F)(F)F)c2)nc2c(F)cccc12
|
O=C([O-])c1cc(-c2cccc(CCCCC(F)(F)F)c2)nc2c(F)cccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C4(F)(F)F"
}
|
Can you make molecule O=C([O-])c1cc(-c2cccc(C(F)(F)F)c2)nc2c(F)cccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1cc(-c2cccc(C(F)(F)C(F)(F)F)c2)nc2c(F)cccc12
|
O=C([O-])c1cc(-c2cccc(C(F)(F)F)c2)nc2c(F)cccc12
|
O=C([O-])c1cc(-c2cccc(C(F)(F)C(F)(F)F)c2)nc2c(F)cccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(F)(F)C(F)(F)F",
"old_substring": "C4(F)(F)F"
}
|
Can you make molecule O=C([O-])c1cc(-c2cccc(C(F)(F)F)c2)nc2c(F)cccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1cc(-c2cccc(CC(F)(F)C(F)(F)F)c2)nc2c(F)cccc12
|
O=C([O-])c1cc(-c2cccc(C(F)(F)F)c2)nc2c(F)cccc12
|
O=C([O-])c1cc(-c2cccc(CC(F)(F)C(F)(F)F)c2)nc2c(F)cccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)(F)F",
"old_substring": "C4(F)(F)F"
}
|
Can you make molecule CC(C)(C)OC(=O)N1CCC[C@@H](COS(C)(=O)=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)OC(=O)CC(C)(C)N1CCC[C@@H](COS(C)(=O)=O)C1
|
CC(C)(C)OC(=O)N1CCC[C@@H](COS(C)(=O)=O)C1
|
CC(C)(C)OC(=O)CC(C)(C)N1CCC[C@@H](COS(C)(=O)=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)(C)OC(=O)N1CCC[C@@H](COS(C)(=O)=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)OC(=O)CCC(C)(C)N1CCC[C@@H](COS(C)(=O)=O)C1
|
CC(C)(C)OC(=O)N1CCC[C@@H](COS(C)(=O)=O)C1
|
CC(C)(C)OC(=O)CCC(C)(C)N1CCC[C@@H](COS(C)(=O)=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)(C)OC(=O)N1CCC[C@@H](COS(C)(=O)=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)OC(=O)C[C@@H](Br)N1CCC[C@@H](COS(C)(=O)=O)C1
|
CC(C)(C)OC(=O)N1CCC[C@@H](COS(C)(=O)=O)C1
|
CC(C)(C)OC(=O)C[C@@H](Br)N1CCC[C@@H](COS(C)(=O)=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)(C)OC(=O)N1CCC[C@@H](COS(C)(=O)=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=C(OOC(C)(C)C)c1ccc(N2CCC[C@@H](COS(C)(=O)=O)C2)cc1
|
CC(C)(C)OC(=O)N1CCC[C@@H](COS(C)(=O)=O)C1
|
C=C(OOC(C)(C)C)c1ccc(N2CCC[C@@H](COS(C)(=O)=O)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C(O&)c1ccc&cc1",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)(C)OC(=O)N1CCC[C@@H](COS(C)(=O)=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(OC(C)(C)C)C(=O)CCN1CCC[C@@H](COS(C)(=O)=O)C1
|
CC(C)(C)OC(=O)N1CCC[C@@H](COS(C)(=O)=O)C1
|
CCC(CC)(OC(C)(C)C)C(=O)CCN1CCC[C@@H](COS(C)(=O)=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C23=O"
}
|
Can you make molecule CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2Cl)C1
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2)C1
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c14ccccc1"
}
|
Can you make molecule CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccc(I)cc2)C1
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2)C1
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccc(I)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c14ccccc1"
}
|
Can you make molecule CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccc(C)c(I)c2)C1
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2)C1
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccc(C)c(I)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c14ccccc1"
}
|
Can you make molecule CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2cccc(Br)c2)C1
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2)C1
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2cccc(Br)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c14ccccc1"
}
|
Can you make molecule CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2cccc(C)c2C)C1
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2ccccc2)C1
|
CC/[NH+]=C(/NCc1nc(C)no1)N[C@H]1CCN(c2cccc(C)c2C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c14ccccc1"
}
|
Can you make molecule CCc1noc(CC)c1CNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1noc(CC)c1CSCNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1
|
CCc1noc(CC)c1CNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1
|
CCc1noc(CC)c1CSCNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N35"
}
|
Can you make molecule CCc1noc(CC)c1CNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1noc(CC)c1CSC(=N)NC(=O)Nc1cnn(C[C@@H]2CCCO2)c1
|
CCc1noc(CC)c1CNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1
|
CCc1noc(CC)c1CSC(=N)NC(=O)Nc1cnn(C[C@@H]2CCCO2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N35"
}
|
Can you make molecule CCc1noc(CC)c1CNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1noc(CC)c1CSC(=S)N(C)C(=O)Nc1cnn(C[C@@H]2CCCO2)c1
|
CCc1noc(CC)c1CNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1
|
CCc1noc(CC)c1CSC(=S)N(C)C(=O)Nc1cnn(C[C@@H]2CCCO2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N35"
}
|
Can you make molecule CCc1noc(CC)c1CNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1noc(CC)c1CSC1=NCCN1C(=O)Nc1cnn(C[C@@H]2CCCO2)c1
|
CCc1noc(CC)c1CNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1
|
CCc1noc(CC)c1CSC1=NCCN1C(=O)Nc1cnn(C[C@@H]2CCCO2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N35"
}
|
Can you make molecule CCc1noc(CC)c1CNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1noc(CC)c1CC1CCN(CC(=O)Nc2cnn(C[C@@H]3CCCO3)c2)CC1
|
CCc1noc(CC)c1CNC(=O)Nc1cnn(C[C@@H]2CCCO2)c1
|
CCc1noc(CC)c1CC1CCN(CC(=O)Nc2cnn(C[C@@H]3CCCO3)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N35"
}
|
Can you make molecule Cc1cnc(C(C)(C)NC(=O)N[C@H]2C[C@H]2C2CCCCC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(C(C)(C)NC(=O)CC(C)(C)N[C@H]2C[C@H]2C2CCCCC2)s1
|
Cc1cnc(C(C)(C)NC(=O)N[C@H]2C[C@H]2C2CCCCC2)s1
|
Cc1cnc(C(C)(C)NC(=O)CC(C)(C)N[C@H]2C[C@H]2C2CCCCC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule Cc1cnc(C(C)(C)NC(=O)N[C@H]2C[C@H]2C2CCCCC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(C(C)(C)NC(=O)CCC(C)(C)N[C@H]2C[C@H]2C2CCCCC2)s1
|
Cc1cnc(C(C)(C)NC(=O)N[C@H]2C[C@H]2C2CCCCC2)s1
|
Cc1cnc(C(C)(C)NC(=O)CCC(C)(C)N[C@H]2C[C@H]2C2CCCCC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule Cc1cnc(C(C)(C)NC(=O)N[C@H]2C[C@H]2C2CCCCC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(C(C)(C)Nc2c(C)n(C)n(N[C@H]3C[C@H]3C3CCCCC3)c2=O)s1
|
Cc1cnc(C(C)(C)NC(=O)N[C@H]2C[C@H]2C2CCCCC2)s1
|
Cc1cnc(C(C)(C)Nc2c(C)n(C)n(N[C@H]3C[C@H]3C3CCCCC3)c2=O)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)n&n1C",
"old_substring": "C34=O"
}
|
Can you make molecule Cc1cnc(C(C)(C)NC(=O)N[C@H]2C[C@H]2C2CCCCC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(C(C)(C)Nc2nn(N[C@H]3C[C@H]3C3CCCCC3)c(C)cc2=O)s1
|
Cc1cnc(C(C)(C)NC(=O)N[C@H]2C[C@H]2C2CCCCC2)s1
|
Cc1cnc(C(C)(C)Nc2nn(N[C@H]3C[C@H]3C3CCCCC3)c(C)cc2=O)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(=O)c&nn1&",
"old_substring": "C34=O"
}
|
Can you make molecule Cc1cnc(C(C)(C)NC(=O)N[C@H]2C[C@H]2C2CCCCC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(C(C)(C)NC(=O)C[C@@H](Br)N[C@H]2C[C@H]2C2CCCCC2)s1
|
Cc1cnc(C(C)(C)NC(=O)N[C@H]2C[C@H]2C2CCCCC2)s1
|
Cc1cnc(C(C)(C)NC(=O)C[C@@H](Br)N[C@H]2C[C@H]2C2CCCCC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule C[C@@H](NC(=O)CN1C(=O)COCC1=O)c1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(C)(C)c1ccco1)NC(=O)CN1C(=O)COCC1=O
|
C[C@@H](NC(=O)CN1C(=O)COCC1=O)c1ccco1
|
C[C@H](CC(C)(C)c1ccco1)NC(=O)CN1C(=O)COCC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@@H]35"
}
|
Can you make molecule C[C@@H](NC(=O)CN1C(=O)COCC1=O)c1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCNC(=O)CN1C(=O)COCC1=O)CC(=O)c1ccco1
|
C[C@@H](NC(=O)CN1C(=O)COCC1=O)c1ccco1
|
C[C@@H](CCNC(=O)CN1C(=O)COCC1=O)CC(=O)c1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@@H]35"
}
|
Can you make molecule C[C@@H](NC(=O)CN1C(=O)COCC1=O)c1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CN1C(=O)COCC1=O)NCC[C@H](Cl)c1ccco1
|
C[C@@H](NC(=O)CN1C(=O)COCC1=O)c1ccco1
|
O=C(CN1C(=O)COCC1=O)NCC[C@H](Cl)c1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C[C@@H]&Cl",
"old_substring": "C[C@@H]35"
}
|
Can you make molecule C[C@@H](NC(=O)CN1C(=O)COCC1=O)c1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H](CC(=O)c1ccco1)NC(=O)CN1C(=O)COCC1=O
|
C[C@@H](NC(=O)CN1C(=O)COCC1=O)c1ccco1
|
CCC[C@H](CC(=O)c1ccco1)NC(=O)CN1C(=O)COCC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@@H]&CC&=O",
"old_substring": "C[C@@H]35"
}
|
Can you make molecule C[C@@H](NC(=O)CN1C(=O)COCC1=O)c1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](CCc1ccco1)NC(=O)CN1C(=O)COCC1=O
|
C[C@@H](NC(=O)CN1C(=O)COCC1=O)c1ccco1
|
CC(C)[C@H](CCc1ccco1)NC(=O)CN1C(=O)COCC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)[C@@H]&CC&",
"old_substring": "C[C@@H]35"
}
|
Can you make molecule O=C(NC1CC[NH+](CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC1CCN(CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21
|
O=C(NC1CC[NH+](CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21
|
O=C(NC1CCN(CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCN&CC1",
"old_substring": "C18CC[NH+]7CC1"
}
|
Can you make molecule O=C(NC1CC[NH+](CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC[NH+]1CCC(CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21
|
O=C(NC1CC[NH+](CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21
|
O=C(NC[NH+]1CCC(CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&CC1",
"old_substring": "C18CC[NH+]7CC1"
}
|
Can you make molecule O=C(NC1CC[NH+](CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC1CCC(CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21
|
O=C(NC1CC[NH+](CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21
|
O=C(NC1CCC(CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C18CC[NH+]7CC1"
}
|
Can you make molecule O=C(NC1CC[NH+](CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC1CC(CCOc2ccc(F)cc2)C1)N1CCc2cc(Cl)ccc21
|
O=C(NC1CC[NH+](CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21
|
O=C(NC1CC(CCOc2ccc(F)cc2)C1)N1CCc2cc(Cl)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C18CC[NH+]7CC1"
}
|
Can you make molecule O=C(NC1CC[NH+](CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CN(NC(=O)N2CCc3cc(Cl)ccc32)CCN1CCOc1ccc(F)cc1
|
O=C(NC1CC[NH+](CCOc2ccc(F)cc2)CC1)N1CCc2cc(Cl)ccc21
|
C[C@@H]1CN(NC(=O)N2CCc3cc(Cl)ccc32)CCN1CCOc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN&[C@H](C)C1",
"old_substring": "C18CC[NH+]7CC1"
}
|
Can you make molecule COc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC
|
COc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC
|
COCc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC
|
COc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC
|
COCSc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)ccc1SC(C)=O
|
COc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC
|
COc1cc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)ccc1SC(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)ccc1C(=O)CS
|
COc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC
|
COc1cc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)ccc1C(=O)CS
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)ccc1C(=O)CI
|
COc1ccc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)cc1OC
|
COc1cc(-c2ccnc3nc(Nc4ccc(C)cc4C)[nH]c(=O)c23)ccc1C(=O)CI
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO5"
}
|
Can you make molecule C[C@@H]1C[C@@H](N2CCN(C(=O)c3cccs3)CC2)C(=O)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3ccc(Cl)s3)CC2)C(=O)O1
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3cccs3)CC2)C(=O)O1
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3ccc(Cl)s3)CC2)C(=O)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)s1",
"old_substring": "c16cccs1"
}
|
Can you make molecule C[C@@H]1C[C@@H](N2CCN(C(=O)c3cccs3)CC2)C(=O)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3ccc(Br)s3)CC2)C(=O)O1
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3cccs3)CC2)C(=O)O1
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3ccc(Br)s3)CC2)C(=O)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)s1",
"old_substring": "c16cccs1"
}
|
Can you make molecule C[C@@H]1C[C@@H](N2CCN(C(=O)c3cccs3)CC2)C(=O)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3sccc3Br)CC2)C(=O)O1
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3cccs3)CC2)C(=O)O1
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3sccc3Br)CC2)C(=O)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sccc1Br",
"old_substring": "c16cccs1"
}
|
Can you make molecule C[C@@H]1C[C@@H](N2CCN(C(=O)c3cccs3)CC2)C(=O)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3csc(I)c3)CC2)C(=O)O1
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3cccs3)CC2)C(=O)O1
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3csc(I)c3)CC2)C(=O)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&csc(I)c1",
"old_substring": "c16cccs1"
}
|
Can you make molecule C[C@@H]1C[C@@H](N2CCN(C(=O)c3cccs3)CC2)C(=O)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3cc4c(s3)CSC4)CC2)C(=O)O1
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3cccs3)CC2)C(=O)O1
|
C[C@@H]1C[C@@H](N2CCN(C(=O)c3cc4c(s3)CSC4)CC2)C(=O)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2c(s1)CSC2",
"old_substring": "c16cccs1"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCSC1
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO1
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCSC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCSC1",
"old_substring": "[C@@H]16CCCO1"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1C=CCC1
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO1
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1C=CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&C=CCC1",
"old_substring": "[C@@H]16CCCO1"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCSC1
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO1
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCSC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCSC1",
"old_substring": "[C@@H]16CCCO1"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@H]1CCCOCC1
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO1
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@H]1CCCOCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCOCC1",
"old_substring": "[C@@H]16CCCO1"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO[C@H]1C
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO1
|
CCc1nn(C)cc1NC(=O)N[C@@H](CC)[C@@H]1CCCO[C@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCO[C@H]1C",
"old_substring": "[C@@H]16CCCO1"
}
|
Can you make molecule C=CCN1C(=O)C(=Cc2c(-c3ccccc3)[nH]c3ccccc23)C(=O)N=C1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCN1C(=O)C(=Cc2c(-c3ccccc3Cl)[nH]c3ccccc23)C(=O)N=C1[O-]
|
C=CCN1C(=O)C(=Cc2c(-c3ccccc3)[nH]c3ccccc23)C(=O)N=C1[O-]
|
C=CCN1C(=O)C(=Cc2c(-c3ccccc3Cl)[nH]c3ccccc23)C(=O)N=C1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c16ccccc1"
}
|
Can you make molecule C=CCN1C(=O)C(=Cc2c(-c3ccccc3)[nH]c3ccccc23)C(=O)N=C1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCN1C(=O)C(=Cc2c(-c3ccc(I)cc3)[nH]c3ccccc23)C(=O)N=C1[O-]
|
C=CCN1C(=O)C(=Cc2c(-c3ccccc3)[nH]c3ccccc23)C(=O)N=C1[O-]
|
C=CCN1C(=O)C(=Cc2c(-c3ccc(I)cc3)[nH]c3ccccc23)C(=O)N=C1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c16ccccc1"
}
|
Can you make molecule C=CCN1C(=O)C(=Cc2c(-c3ccccc3)[nH]c3ccccc23)C(=O)N=C1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCN1C(=O)C(=Cc2c(-c3ccc(C)c(I)c3)[nH]c3ccccc23)C(=O)N=C1[O-]
|
C=CCN1C(=O)C(=Cc2c(-c3ccccc3)[nH]c3ccccc23)C(=O)N=C1[O-]
|
C=CCN1C(=O)C(=Cc2c(-c3ccc(C)c(I)c3)[nH]c3ccccc23)C(=O)N=C1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c16ccccc1"
}
|
Can you make molecule C=CCN1C(=O)C(=Cc2c(-c3ccccc3)[nH]c3ccccc23)C(=O)N=C1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCN1C(=O)C(=Cc2c(-c3cccc(Br)c3)[nH]c3ccccc23)C(=O)N=C1[O-]
|
C=CCN1C(=O)C(=Cc2c(-c3ccccc3)[nH]c3ccccc23)C(=O)N=C1[O-]
|
C=CCN1C(=O)C(=Cc2c(-c3cccc(Br)c3)[nH]c3ccccc23)C(=O)N=C1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c16ccccc1"
}
|
Can you make molecule C=CCN1C(=O)C(=Cc2c(-c3ccccc3)[nH]c3ccccc23)C(=O)N=C1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCN1C(=O)C(=Cc2c(-c3cccc(C)c3C)[nH]c3ccccc23)C(=O)N=C1[O-]
|
C=CCN1C(=O)C(=Cc2c(-c3ccccc3)[nH]c3ccccc23)C(=O)N=C1[O-]
|
C=CCN1C(=O)C(=Cc2c(-c3cccc(C)c3C)[nH]c3ccccc23)C(=O)N=C1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c16ccccc1"
}
|
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