prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule C[C@@]1(C(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@]1(CC(=O)SNC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
|
C[C@@]1(C(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
|
C[C@@]1(CC(=O)SNC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule C[C@@]1(C(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@]1(CC(=C=O)CNC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
|
C[C@@]1(C(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
|
C[C@@]1(CC(=C=O)CNC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule C[C@@]1(C(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@]1(C(=O)CCCC(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
|
C[C@@]1(C(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
|
C[C@@]1(C(=O)CCCC(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule C[C@@]1(C(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)NC1CCCC1)[C@]1(C)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
|
C[C@@]1(C(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
|
CC(C)(CC(=O)NC1CCCC1)[C@]1(C)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule C[C@@]1(C(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@]1(CCC[S@@+]([O-])CNC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
|
C[C@@]1(C(=O)NC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
|
C[C@@]1(CCC[S@@+]([O-])CNC2CCCC2)Cn2c(nc3ccccc32)C(=O)N1Cc1cccc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCC1",
"old_substring": "N15CCCCC1"
}
|
Can you make molecule Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCCC1",
"old_substring": "N15CCCCC1"
}
|
Can you make molecule Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCC(C)(C)C3)ccc2N2CC[NH+](C)CC2)c(C)s1
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCC(C)(C)C3)ccc2N2CC[NH+](C)CC2)c(C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC(C)(C)C1",
"old_substring": "N15CCCCC1"
}
|
Can you make molecule Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCC(C)(C)CC3)ccc2N2CC[NH+](C)CC2)c(C)s1
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCC(C)(C)CC3)ccc2N2CC[NH+](C)CC2)c(C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC(C)(C)CC1",
"old_substring": "N15CCCCC1"
}
|
Can you make molecule Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CC4(CCCCC4)C3)ccc2N2CC[NH+](C)CC2)c(C)s1
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CCCCC3)ccc2N2CC[NH+](C)CC2)c(C)s1
|
Cc1cc(C(=O)Nc2cc(S(=O)(=O)N3CC4(CCCCC4)C3)ccc2N2CC[NH+](C)CC2)c(C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC2(CCCCC2)C1",
"old_substring": "N15CCCCC1"
}
|
Can you make molecule Cc1noc(NC(=O)C[C@H](C)c2ccc(F)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(NC(=O)C[C@H](c2ccc(F)cc2)C(C)C)n1
|
Cc1noc(NC(=O)C[C@H](C)c2ccc(F)cc2)n1
|
Cc1noc(NC(=O)C[C@H](c2ccc(F)cc2)C(C)C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&C(C)C",
"old_substring": "C3(=O)C[C@@H]5C"
}
|
Can you make molecule Cc1noc(NC(=O)C[C@H](C)c2ccc(F)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(NCC[C@H](Cl)c2ccc(F)cc2)n1
|
Cc1noc(NC(=O)C[C@H](C)c2ccc(F)cc2)n1
|
Cc1noc(NCC[C@H](Cl)c2ccc(F)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C[C@@H]&Cl",
"old_substring": "C3(=O)C[C@@H]5C"
}
|
Can you make molecule Cc1noc(NC(=O)C[C@H](C)c2ccc(F)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(N[C@@H](CCc2ccc(F)cc2)C(C)C)n1
|
Cc1noc(NC(=O)C[C@H](C)c2ccc(F)cc2)n1
|
Cc1noc(N[C@@H](CCc2ccc(F)cc2)C(C)C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)[C@@H]&CC&",
"old_substring": "C3(=O)C[C@@H]5C"
}
|
Can you make molecule Cc1noc(NC(=O)C[C@H](C)c2ccc(F)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(N=CCC[C@@H](C)Cc2ccc(F)cc2)n1
|
Cc1noc(NC(=O)C[C@H](C)c2ccc(F)cc2)n1
|
Cc1noc(N=CCC[C@@H](C)Cc2ccc(F)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@@H](C)C&",
"old_substring": "C3(=O)C[C@@H]5C"
}
|
Can you make molecule Cc1noc(NC(=O)C[C@H](C)c2ccc(F)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1noc(NC(=O)CCC(C)(C)c2ccc(F)cc2)n1
|
Cc1noc(NC(=O)C[C@H](C)c2ccc(F)cc2)n1
|
Cc1noc(NC(=O)CCC(C)(C)c2ccc(F)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C3(=O)C[C@@H]5C"
}
|
Can you make molecule Cc1ncsc1COC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1COSC(=O)Cc1cc(-c2ccccc2)nc2c1c(C)nn2C
|
Cc1ncsc1COC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C
|
Cc1ncsc1COSC(=O)Cc1cc(-c2ccccc2)nc2c1c(C)nn2C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1ncsc1COC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1COC(=O)CCCC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C
|
Cc1ncsc1COC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C
|
Cc1ncsc1COC(=O)CCCC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1ncsc1COC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1COC(=O)CC(C)(C)c1cc(-c2ccccc2)nc2c1c(C)nn2C
|
Cc1ncsc1COC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C
|
Cc1ncsc1COC(=O)CC(C)(C)c1cc(-c2ccccc2)nc2c1c(C)nn2C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1ncsc1COC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1COC(=O)CCC(C)(C)c1cc(-c2ccccc2)nc2c1c(C)nn2C
|
Cc1ncsc1COC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C
|
Cc1ncsc1COC(=O)CCC(C)(C)c1cc(-c2ccccc2)nc2c1c(C)nn2C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1ncsc1COC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ncsc1COSC(=O)[C@@H](C)c1cc(-c2ccccc2)nc2c1c(C)nn2C
|
Cc1ncsc1COC(=O)c1cc(-c2ccccc2)nc2c1c(C)nn2C
|
Cc1ncsc1COSC(=O)[C@@H](C)c1cc(-c2ccccc2)nc2c1c(C)nn2C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)c3nonc3N)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c2ccccc2c2cc(C[NH2+]CCNSC(=O)Cc3nonc3N)ccc21
|
CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)c3nonc3N)ccc21
|
CCn1c2ccccc2c2cc(C[NH2+]CCNSC(=O)Cc3nonc3N)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C48=O"
}
|
Can you make molecule CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)c3nonc3N)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)CCCC(=O)c3nonc3N)ccc21
|
CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)c3nonc3N)ccc21
|
CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)CCCC(=O)c3nonc3N)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C48=O"
}
|
Can you make molecule CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)c3nonc3N)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)CC(C)(C)c3nonc3N)ccc21
|
CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)c3nonc3N)ccc21
|
CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)CC(C)(C)c3nonc3N)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C48=O"
}
|
Can you make molecule CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)c3nonc3N)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)CCC(C)(C)c3nonc3N)ccc21
|
CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)c3nonc3N)ccc21
|
CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)CCC(C)(C)c3nonc3N)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C48=O"
}
|
Can you make molecule CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)c3nonc3N)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c2ccccc2c2cc(C[NH2+]CCNSC(=O)[C@@H](C)c3nonc3N)ccc21
|
CCn1c2ccccc2c2cc(C[NH2+]CCNC(=O)c3nonc3N)ccc21
|
CCn1c2ccccc2c2cc(C[NH2+]CCNSC(=O)[C@@H](C)c3nonc3N)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C48=O"
}
|
Can you make molecule C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1I
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c18ccc6cc1"
}
|
Can you make molecule C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1cc(N2CCOCC2)ccc1Br
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1cc(N2CCOCC2)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c18ccc6cc1"
}
|
Can you make molecule C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1Cl
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c18ccc6cc1"
}
|
Can you make molecule C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1cccc(N2CCOCC2)c1Br
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1cccc(N2CCOCC2)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c18ccc6cc1"
}
|
Can you make molecule C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1cccc(N2CCOCC2)c1Cl
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1ccc(N2CCOCC2)cc1
|
C[C@H](NC(=O)[C@H]1CCCN(S(C)(=O)=O)C1)c1cccc(N2CCOCC2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c18ccc6cc1"
}
|
Can you make molecule O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2Cl)C1
|
O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2)C1
|
O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccncc1Cl",
"old_substring": "c16ccncc1"
}
|
Can you make molecule O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccccc2)C1
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O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2)C1
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O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccccc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1",
"old_substring": "c16ccncc1"
}
|
Can you make molecule O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2cnccc2Cl)C1
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O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2)C1
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O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2cnccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cnccc1Cl",
"old_substring": "c16ccncc1"
}
|
Can you make molecule O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2cc(Br)ncc2F)C1
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O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2)C1
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O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2cc(Br)ncc2F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)ncc1F",
"old_substring": "c16ccncc1"
}
|
Can you make molecule O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1cc(-c2cncnc2[C@H]2CCCN(C(=O)CCn3c(=O)oc4ccccc43)C2)ncc1Br
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O=C(CCn1c(=O)oc2ccccc21)N1CCC[C@H](c2ncncc2-c2ccncc2)C1
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Cc1cc(-c2cncnc2[C@H]2CCCN(C(=O)CCn3c(=O)oc4ccccc43)C2)ncc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&ncc1Br",
"old_substring": "c16ccncc1"
}
|
Can you make molecule COc1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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COc1ccc(CC(=O)SNc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
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COc1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
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COc1ccc(CC(=O)SNc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C38=O"
}
|
Can you make molecule COc1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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COc1ccc(C(=O)CCCC(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
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COc1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
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COc1ccc(C(=O)CCCC(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C38=O"
}
|
Can you make molecule COc1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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COc1ccc(C(C)(C)CC(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
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COc1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
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COc1ccc(C(C)(C)CC(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C38=O"
}
|
Can you make molecule COc1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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COc1ccc(C(C)(C)CCC(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
|
COc1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
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COc1ccc(C(C)(C)CCC(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C38=O"
}
|
Can you make molecule COc1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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COc1ccc([C@H](C)C(=O)SNc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
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COc1ccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
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COc1ccc([C@H](C)C(=O)SNc2ccccc2C(=O)Nc2ccc(F)cc2C)cc1
| 102
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{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C38=O"
}
|
Can you make molecule O=C(NC(=S)NC[C@@H]1CCCO1)c1ccc(Cl)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
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O=Cc1c(NC(=S)NC[C@@H]2CCCO2)oc2ccc(-c3ccc(Cl)cc3Cl)cc12
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O=C(NC(=S)NC[C@@H]1CCCO1)c1ccc(Cl)cc1Cl
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O=Cc1c(NC(=S)NC[C@@H]2CCCO2)oc2ccc(-c3ccc(Cl)cc3Cl)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1c&oc2ccc&cc12",
"old_substring": "O=C24"
}
|
Can you make molecule O=C(NC(=S)NC[C@@H]1CCCO1)c1ccc(Cl)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
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O=C(/C=C/Sc1ccc(Cl)cc1Cl)NC(=S)NC[C@@H]1CCCO1
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O=C(NC(=S)NC[C@@H]1CCCO1)c1ccc(Cl)cc1Cl
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O=C(/C=C/Sc1ccc(Cl)cc1Cl)NC(=S)NC[C@@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C24"
}
|
Can you make molecule O=C(NC(=S)NC[C@@H]1CCCO1)c1ccc(Cl)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
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O=Cc1sc(NC(=S)NC[C@@H]2CCCO2)nc1-c1ccc(Cl)cc1Cl
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O=C(NC(=S)NC[C@@H]1CCCO1)c1ccc(Cl)cc1Cl
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O=Cc1sc(NC(=S)NC[C@@H]2CCCO2)nc1-c1ccc(Cl)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C24"
}
|
Can you make molecule O=C(NC(=S)NC[C@@H]1CCCO1)c1ccc(Cl)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
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O=Cc1nc(NC(=S)NC[C@@H]2CCCO2)sc1-c1ccc(Cl)cc1Cl
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O=C(NC(=S)NC[C@@H]1CCCO1)c1ccc(Cl)cc1Cl
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O=Cc1nc(NC(=S)NC[C@@H]2CCCO2)sc1-c1ccc(Cl)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C24"
}
|
Can you make molecule O=C(NC(=S)NC[C@@H]1CCCO1)c1ccc(Cl)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
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O=C(NC(=S)NC[C@@H]1CCCO1)n1nc(-c2ccc(Cl)cc2Cl)oc1=S
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O=C(NC(=S)NC[C@@H]1CCCO1)c1ccc(Cl)cc1Cl
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O=C(NC(=S)NC[C@@H]1CCCO1)n1nc(-c2ccc(Cl)cc2Cl)oc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&n1nc&oc1=S",
"old_substring": "O=C24"
}
|
Can you make molecule O=C(Nc1ccccc1)c1cccc(OC(=O)c2ncn(-c3ccccc3)n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
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Clc1ccccc1.O=C(Nc1ccccc1)c1cccc(OC(=O)c2nc[nH]n2)c1
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O=C(Nc1ccccc1)c1cccc(OC(=O)c2ncn(-c3ccccc3)n2)c1
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Clc1ccccc1.O=C(Nc1ccccc1)c1cccc(OC(=O)c2nc[nH]n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c1%10ccccc1"
}
|
Can you make molecule O=C(Nc1ccccc1)c1cccc(OC(=O)c2ncn(-c3ccccc3)n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
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Fc1ccccc1.O=C(Nc1ccccc1)c1cccc(OC(=O)c2nc[nH]n2)c1
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O=C(Nc1ccccc1)c1cccc(OC(=O)c2ncn(-c3ccccc3)n2)c1
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Fc1ccccc1.O=C(Nc1ccccc1)c1cccc(OC(=O)c2nc[nH]n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Fc1cccc&c1",
"old_substring": "c1%10ccccc1"
}
|
Can you make molecule O=C(Nc1ccccc1)c1cccc(OC(=O)c2ncn(-c3ccccc3)n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1ccccc1.O=C(Nc1ccccc1)c1cccc(OC(=O)c2nc[nH]n2)c1
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O=C(Nc1ccccc1)c1cccc(OC(=O)c2ncn(-c3ccccc3)n2)c1
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Cc1ccccc1.O=C(Nc1ccccc1)c1cccc(OC(=O)c2nc[nH]n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cccc&c1",
"old_substring": "c1%10ccccc1"
}
|
Can you make molecule O=C(Nc1ccccc1)c1cccc(OC(=O)c2ncn(-c3ccccc3)n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Ic1ccccc1.O=C(Nc1ccccc1)c1cccc(OC(=O)c2nc[nH]n2)c1
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O=C(Nc1ccccc1)c1cccc(OC(=O)c2ncn(-c3ccccc3)n2)c1
|
Ic1ccccc1.O=C(Nc1ccccc1)c1cccc(OC(=O)c2nc[nH]n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c1%10ccccc1"
}
|
Can you make molecule O=C(Nc1ccccc1)c1cccc(OC(=O)c2ncn(-c3ccccc3)n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc(F)cc1.O=C(Nc1ccccc1)c1cccc(OC(=O)c2nc[nH]n2)c1
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O=C(Nc1ccccc1)c1cccc(OC(=O)c2ncn(-c3ccccc3)n2)c1
|
Fc1ccc(F)cc1.O=C(Nc1ccccc1)c1cccc(OC(=O)c2nc[nH]n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1F",
"old_substring": "c1%10ccccc1"
}
|
Can you make molecule C#CCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCCCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
|
C#CCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
|
C#CCCCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C#CCCC&",
"old_substring": "C#CC5"
}
|
Can you make molecule C#CCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCCCCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
|
C#CCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
|
C#CCCCCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C#CCCCC&",
"old_substring": "C#CC5"
}
|
Can you make molecule C#CCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CC(C)(C)N1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
|
C#CCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
|
C#CC(C)(C)N1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C#CC&(C)C",
"old_substring": "C#CC5"
}
|
Can you make molecule C#CCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCC(C)(C)N1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
|
C#CCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
|
C#CCC(C)(C)N1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C#CCC&(C)C",
"old_substring": "C#CC5"
}
|
Can you make molecule C#CCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CC(CC)(CC)N1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
|
C#CCN1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
|
C#CC(CC)(CC)N1CCN(C(=O)c2cnc([C@@H]3CCCO3)s2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C#CC&(CC)CC",
"old_substring": "C#CC5"
}
|
Can you make molecule Cc1cccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)cc1I
|
Cc1cccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1
|
Cc1ccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "Cc1cccc7c1"
}
|
Can you make molecule Cc1cccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)cc1Cl
|
Cc1cccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1
|
Cc1ccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1Cl",
"old_substring": "Cc1cccc7c1"
}
|
Can you make molecule Cc1cccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(I)ccc1OCC(=O)NCc1ccc(-c2nc3ncccc3o2)cc1
|
Cc1cccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1
|
Cc1cc(I)ccc1OCC(=O)NCc1ccc(-c2nc3ncccc3o2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(I)ccc1&",
"old_substring": "Cc1cccc7c1"
}
|
Can you make molecule Cc1cccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(I)c(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1
|
Cc1cccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1
|
Cc1ccc(I)c(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(I)c&c1",
"old_substring": "Cc1cccc7c1"
}
|
Can you make molecule Cc1cccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Br)c(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1
|
Cc1cccc(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1
|
Cc1ccc(Br)c(OCC(=O)NCc2ccc(-c3nc4ncccc4o3)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(Br)c&c1",
"old_substring": "Cc1cccc7c1"
}
|
Can you make molecule COCCC[NH2+][C@H](C)[C@H]1CCC[NH+](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]([NH2+]CCCC1OCc2ccccc2CO1)[C@H]1CCC[NH+](C)C1
|
COCCC[NH2+][C@H](C)[C@H]1CCC[NH+](C)C1
|
C[C@@H]([NH2+]CCCC1OCc2ccccc2CO1)[C@H]1CCC[NH+](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&OCc2ccccc2CO1",
"old_substring": "CO2"
}
|
Can you make molecule COCCC[NH2+][C@H](C)[C@H]1CCC[NH+](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]([NH2+]CCCC1(O)Cc2ccccc2C1)[C@H]1CCC[NH+](C)C1
|
COCCC[NH2+][C@H](C)[C@H]1CCC[NH+](C)C1
|
C[C@@H]([NH2+]CCCC1(O)Cc2ccccc2C1)[C@H]1CCC[NH+](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(O)Cc2ccccc2C1",
"old_substring": "CO2"
}
|
Can you make molecule COCCC[NH2+][C@H](C)[C@H]1CCC[NH+](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]([NH2+]CCC=C1Oc2ccccc2C1=O)[C@H]1CCC[NH+](C)C1
|
COCCC[NH2+][C@H](C)[C@H]1CCC[NH+](C)C1
|
C[C@@H]([NH2+]CCC=C1Oc2ccccc2C1=O)[C@H]1CCC[NH+](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&Oc2ccccc2C1=O",
"old_substring": "CO2"
}
|
Can you make molecule COCCC[NH2+][C@H](C)[C@H]1CCC[NH+](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]([NH2+]CCC=C1CCOC2(CCC2)C1)[C@H]1CCC[NH+](C)C1
|
COCCC[NH2+][C@H](C)[C@H]1CCC[NH+](C)C1
|
C[C@@H]([NH2+]CCC=C1CCOC2(CCC2)C1)[C@H]1CCC[NH+](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCOC2(CCC2)C1",
"old_substring": "CO2"
}
|
Can you make molecule COCCC[NH2+][C@H](C)[C@H]1CCC[NH+](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]([NH2+]CCC=C(O)c1cc2ccccc2o1)[C@H]1CCC[NH+](C)C1
|
COCCC[NH2+][C@H](C)[C@H]1CCC[NH+](C)C1
|
C[C@@H]([NH2+]CCC=C(O)c1cc2ccccc2o1)[C@H]1CCC[NH+](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(O)c1cc2ccccc2o1",
"old_substring": "CO2"
}
|
Can you make molecule CCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC
|
CCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC
|
C=CSc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC7"
}
|
Can you make molecule CCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(C(C)C)n[nH]c(=O)c1C(=O)Nc1ccc2c(c1)COC2
|
CCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC
|
CCc1c(C(C)C)n[nH]c(=O)c1C(=O)Nc1ccc2c(c1)COC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC7"
}
|
Can you make molecule CCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC
|
CCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC
|
C=CCCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC7"
}
|
Can you make molecule CCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(CCCCl)n[nH]c(=O)c1C(=O)Nc1ccc2c(c1)COC2
|
CCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC
|
CCc1c(CCCCl)n[nH]c(=O)c1C(=O)Nc1ccc2c(c1)COC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC7"
}
|
Can you make molecule CCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(CCCCS)n[nH]c(=O)c1C(=O)Nc1ccc2c(c1)COC2
|
CCc1n[nH]c(=O)c(C(=O)Nc2ccc3c(c2)COC3)c1CC
|
CCc1c(CCCCS)n[nH]c(=O)c1C(=O)Nc1ccc2c(c1)COC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC7"
}
|
Can you make molecule CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccc(I)o1
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccco1
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccc(I)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)o1",
"old_substring": "c16ccco1"
}
|
Can you make molecule CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccc(Br)o1
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccco1
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccc(Br)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)o1",
"old_substring": "c16ccco1"
}
|
Can you make molecule CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccc(Cl)o1
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccco1
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccc(Cl)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)o1",
"old_substring": "c16ccco1"
}
|
Can you make molecule CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1occc1Br
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccco1
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1occc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&occc1Br",
"old_substring": "c16ccco1"
}
|
Can you make molecule CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1sccc1C
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccco1
|
CNc1ccc(C(F)(F)F)cc1C(=O)NCc1sccc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sccc1C",
"old_substring": "c16ccco1"
}
|
Can you make molecule COc1ccccc1C=CC[NH+]1CCN(CCO)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCON1CC[NH+](CC=Cc2ccccc2OC)CC1
|
COc1ccccc1C=CC[NH+]1CCN(CCO)CC1
|
COCON1CC[NH+](CC=Cc2ccccc2OC)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCO&",
"old_substring": "C4CO"
}
|
Can you make molecule COc1ccccc1C=CC[NH+]1CCN(CCO)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CON1CC[NH+](CC=Cc2ccccc2OC)CC1
|
COc1ccccc1C=CC[NH+]1CCN(CCO)CC1
|
C=CON1CC[NH+](CC=Cc2ccccc2OC)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CO&",
"old_substring": "C4CO"
}
|
Can you make molecule COc1ccccc1C=CC[NH+]1CCN(CCO)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)N1CC[NH+](CC=Cc2ccccc2OC)CC1
|
COc1ccccc1C=CC[NH+]1CCN(CCO)CC1
|
CCC(=O)N1CC[NH+](CC=Cc2ccccc2OC)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&=O",
"old_substring": "C4CO"
}
|
Can you make molecule COc1ccccc1C=CC[NH+]1CCN(CCO)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=C=CON1CC[NH+](CC=Cc2ccccc2OC)CC1
|
COc1ccccc1C=CC[NH+]1CCN(CCO)CC1
|
C=C=CON1CC[NH+](CC=Cc2ccccc2OC)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C=CO&",
"old_substring": "C4CO"
}
|
Can you make molecule COc1ccccc1C=CC[NH+]1CCN(CCO)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CC[NH+](CC=Cc2ccccc2OC)CC1
|
COc1ccccc1C=CC[NH+]1CCN(CCO)CC1
|
CCN1CC[NH+](CC=Cc2ccccc2OC)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC&",
"old_substring": "C4CO"
}
|
Can you make molecule Cc1ccc(F)cc1NC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1NSC(=O)Cc1ccc(S(=O)(=O)N2CCCCC2)cc1
|
Cc1ccc(F)cc1NC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1
|
Cc1ccc(F)cc1NSC(=O)Cc1ccc(S(=O)(=O)N2CCCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1ccc(F)cc1NC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1NC(=O)CCCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1
|
Cc1ccc(F)cc1NC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1
|
Cc1ccc(F)cc1NC(=O)CCCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1ccc(F)cc1NC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1NC(=O)CC(C)(C)c1ccc(S(=O)(=O)N2CCCCC2)cc1
|
Cc1ccc(F)cc1NC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1
|
Cc1ccc(F)cc1NC(=O)CC(C)(C)c1ccc(S(=O)(=O)N2CCCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1ccc(F)cc1NC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1NC(=O)CCC(C)(C)c1ccc(S(=O)(=O)N2CCCCC2)cc1
|
Cc1ccc(F)cc1NC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1
|
Cc1ccc(F)cc1NC(=O)CCC(C)(C)c1ccc(S(=O)(=O)N2CCCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1ccc(F)cc1NC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(F)cc1NSC(=O)[C@@H](C)c1ccc(S(=O)(=O)N2CCCCC2)cc1
|
Cc1ccc(F)cc1NC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1
|
Cc1ccc(F)cc1NSC(=O)[C@@H](C)c1ccc(S(=O)(=O)N2CCCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C36=O"
}
|
Can you make molecule CN(C)c1cccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)c1cccc(CC(=O)SN[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
|
CN(C)c1cccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
|
CN(C)c1cccc(CC(=O)SN[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule CN(C)c1cccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)c1cccc(C(=O)CCCC(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
|
CN(C)c1cccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
|
CN(C)c1cccc(C(=O)CCCC(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
}
|
Can you make molecule CN(C)c1cccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)c1cccc(C(C)(C)CC(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
|
CN(C)c1cccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
|
CN(C)c1cccc(C(C)(C)CC(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule CN(C)c1cccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)c1cccc(C(C)(C)CCC(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
|
CN(C)c1cccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
|
CN(C)c1cccc(C(C)(C)CCC(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule CN(C)c1cccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SN[C@H]1[C@H]2CCO[C@@H]2C1(C)C)c1cccc(N(C)C)c1
|
CN(C)c1cccc(C(=O)N[C@H]2[C@H]3CCO[C@@H]3C2(C)C)c1
|
C[C@H](C(=O)SN[C@H]1[C@H]2CCO[C@@H]2C1(C)C)c1cccc(N(C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C47=O"
}
|
Can you make molecule CS(=O)(=O)c1cccc(-c2nnc(NC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CS(=O)(=O)c1cccc(-c2nnc(NSC(=O)Cc3ccc([N+](=O)[O-])cc3)o2)c1
|
CS(=O)(=O)c1cccc(-c2nnc(NC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1
|
CS(=O)(=O)c1cccc(-c2nnc(NSC(=O)Cc3ccc([N+](=O)[O-])cc3)o2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule CS(=O)(=O)c1cccc(-c2nnc(NC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CS(=O)(=O)c1cccc(-c2nnc(NC(=O)CCCC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1
|
CS(=O)(=O)c1cccc(-c2nnc(NC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1
|
CS(=O)(=O)c1cccc(-c2nnc(NC(=O)CCCC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule CS(=O)(=O)c1cccc(-c2nnc(NC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)Nc1nnc(-c2cccc(S(C)(=O)=O)c2)o1)c1ccc([N+](=O)[O-])cc1
|
CS(=O)(=O)c1cccc(-c2nnc(NC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1
|
CC(C)(CC(=O)Nc1nnc(-c2cccc(S(C)(=O)=O)c2)o1)c1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule CS(=O)(=O)c1cccc(-c2nnc(NC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)Nc1nnc(-c2cccc(S(C)(=O)=O)c2)o1)c1ccc([N+](=O)[O-])cc1
|
CS(=O)(=O)c1cccc(-c2nnc(NC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1
|
CC(C)(CCC(=O)Nc1nnc(-c2cccc(S(C)(=O)=O)c2)o1)c1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule CS(=O)(=O)c1cccc(-c2nnc(NC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SNc1nnc(-c2cccc(S(C)(=O)=O)c2)o1)c1ccc([N+](=O)[O-])cc1
|
CS(=O)(=O)c1cccc(-c2nnc(NC(=O)c3ccc([N+](=O)[O-])cc3)o2)c1
|
C[C@H](C(=O)SNc1nnc(-c2cccc(S(C)(=O)=O)c2)o1)c1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C46=O"
}
|
Can you make molecule CCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O
|
CCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O
|
C=CSOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC4"
}
|
Can you make molecule CCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O
|
CCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O
|
C=CCCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC4"
}
|
Can you make molecule CCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)C1=C(C)OC(=O)[C@]12C(C(=O)OCCCCl)=C(N)N(C)c1ccccc12
|
CCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O
|
CC(=O)C1=C(C)OC(=O)[C@]12C(C(=O)OCCCCl)=C(N)N(C)c1ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC4"
}
|
Can you make molecule CCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)C1=C(C)OC(=O)[C@]12C(C(=O)OCCCCS)=C(N)N(C)c1ccccc12
|
CCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O
|
CC(=O)C1=C(C)OC(=O)[C@]12C(C(=O)OCCCCS)=C(N)N(C)c1ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC4"
}
|
Can you make molecule CCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)C1=C(C)OC(=O)[C@]12C(C(=O)OCCCBr)=C(N)N(C)c1ccccc12
|
CCOC(=O)C1=C(N)N(C)c2ccccc2[C@@]12C(=O)OC(C)=C2C(C)=O
|
CC(=O)C1=C(C)OC(=O)[C@]12C(C(=O)OCCCBr)=C(N)N(C)c1ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC4"
}
|
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