prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule [NH2+]=C(NC1CC1)SCc1ccc(Br)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
[NH2+]=C(NC1SCCS1)SCc1ccc(Br)cc1F
|
[NH2+]=C(NC1CC1)SCc1ccc(Br)cc1F
|
[NH2+]=C(NC1SCCS1)SCc1ccc(Br)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCS1",
"old_substring": "C13CC1"
}
|
Can you make molecule [NH2+]=C(NC1CC1)SCc1ccc(Br)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
[NH2+]=C(N=C1CCC1)SCc1ccc(Br)cc1F
|
[NH2+]=C(NC1CC1)SCc1ccc(Br)cc1F
|
[NH2+]=C(N=C1CCC1)SCc1ccc(Br)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCC1",
"old_substring": "C13CC1"
}
|
Can you make molecule [NH2+]=C(NC1CC1)SCc1ccc(Br)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
[NH2+]=C(NC1CCCCC1)SCc1ccc(Br)cc1F
|
[NH2+]=C(NC1CC1)SCc1ccc(Br)cc1F
|
[NH2+]=C(NC1CCCCC1)SCc1ccc(Br)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCC1",
"old_substring": "C13CC1"
}
|
Can you make molecule [NH2+]=C(NC1CC1)SCc1ccc(Br)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
[NH2+]=C(N=C1CCCC1)SCc1ccc(Br)cc1F
|
[NH2+]=C(NC1CC1)SCc1ccc(Br)cc1F
|
[NH2+]=C(N=C1CCCC1)SCc1ccc(Br)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCCC1",
"old_substring": "C13CC1"
}
|
Can you make molecule [NH2+]=C(NC1CC1)SCc1ccc(Br)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
[NH2+]=C(NC1SCCCS1)SCc1ccc(Br)cc1F
|
[NH2+]=C(NC1CC1)SCc1ccc(Br)cc1F
|
[NH2+]=C(NC1SCCCS1)SCc1ccc(Br)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "C13CC1"
}
|
Can you make molecule COc1cc(OC)cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(OC)c(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)cc1I
|
COc1cc(OC)cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c1
|
COc1cc(OC)c(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1I",
"old_substring": "c14cc5cc6c1"
}
|
Can you make molecule COc1cc(OC)cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(OC)c(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)cc1Cl
|
COc1cc(OC)cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c1
|
COc1cc(OC)c(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&cc1Cl",
"old_substring": "c14cc5cc6c1"
}
|
Can you make molecule COc1cc(OC)cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(I)c(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c(OC)c1
|
COc1cc(OC)cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c1
|
COc1cc(I)c(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&cc(I)c1&",
"old_substring": "c14cc5cc6c1"
}
|
Can you make molecule COc1cc(OC)cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)c(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c(OC)c1
|
COc1cc(OC)cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c1
|
COc1cc(Br)c(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&c(Br)c1",
"old_substring": "c14cc5cc6c1"
}
|
Can you make molecule COc1cc(OC)cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c(OC)cc1Br
|
COc1cc(OC)cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c1
|
COc1cc(OCCN[C@@H]2C[C@H](C)[NH+](C)C[C@H]2C)c(OC)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)c&cc1&",
"old_substring": "c14cc5cc6c1"
}
|
Can you make molecule COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3C(F)(F)F)coc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(F)(F)F.COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3)coc2c1
|
COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3C(F)(F)F)coc2c1
|
CC(F)(F)F.COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3)coc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)F",
"old_substring": "C%10(F)(F)F"
}
|
Can you make molecule COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3C(F)(F)F)coc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(F)(F)F.COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3)coc2c1
|
COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3C(F)(F)F)coc2c1
|
CCCC(F)(F)F.COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3)coc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C%10(F)(F)F"
}
|
Can you make molecule COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3C(F)(F)F)coc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3)coc2c1.FC(F)C(F)F
|
COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3C(F)(F)F)coc2c1
|
COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3)coc2c1.FC(F)C(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(F)(F)C(F)F",
"old_substring": "C%10(F)(F)F"
}
|
Can you make molecule COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3C(F)(F)F)coc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(F)(F)F.COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3)coc2c1
|
COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3C(F)(F)F)coc2c1
|
CCCCC(F)(F)F.COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3)coc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C%10(F)(F)F"
}
|
Can you make molecule COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3C(F)(F)F)coc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(F)(F)C(F)F.COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3)coc2c1
|
COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3C(F)(F)F)coc2c1
|
CC(F)(F)C(F)F.COc1ccc2c(CC(=O)Nc3ccc(NC(C)=O)cc3)coc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)F",
"old_substring": "C%10(F)(F)F"
}
|
Can you make molecule O=C(CNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/SNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1
|
O=C(CNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1
|
O=C(/C=C/SNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C2C5"
}
|
Can you make molecule O=C(CNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN1CCC(=NON2CCCCC2)CC1)N1CCC[C@H]1c1ccsc1
|
O=C(CNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1
|
O=C(NN1CCC(=NON2CCCCC2)CC1)N1CCC[C@H]1c1ccsc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "O=C2C5"
}
|
Can you make molecule O=C(CNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCN(NC(=O)N2CCC[C@H]2c2ccsc2)CC1)N1CCCCC1
|
O=C(CNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1
|
O=C(NN=C1CCN(NC(=O)N2CCC[C@H]2c2ccsc2)CC1)N1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCN&CC1",
"old_substring": "O=C2C5"
}
|
Can you make molecule O=C(CNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(NC(=O)N2CCC[C@H]2c2ccsc2)CC1)N1CCCCC1
|
O=C(CNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1
|
O=C(NN=C1CCC(NC(=O)N2CCC[C@H]2c2ccsc2)CC1)N1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C2C5"
}
|
Can you make molecule O=C(CNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\ON1CCCCC1)C(=O)SNC(=O)N1CCC[C@H]1c1ccsc1
|
O=C(CNC(=O)N1CCC[C@H]1c1ccsc1)N1CCCCC1
|
C/C(=N\ON1CCCCC1)C(=O)SNC(=O)N1CCC[C@H]1c1ccsc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)C(=O)S&",
"old_substring": "O=C2C5"
}
|
Can you make molecule CCn1ncc(C[NH2+]C)c1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1ncc(C2=CC=C([NH2+]C)N3CCC3=C2)c1C1CC1
|
CCn1ncc(C[NH2+]C)c1C1CC1
|
CCn1ncc(C2=CC=C([NH2+]C)N3CCC3=C2)c1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2cc&ccc21",
"old_substring": "C24"
}
|
Can you make molecule CCn1ncc(C[NH2+]C)c1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1ncc(-c2ncnc3sc-3c(C)c2[NH2+]C)c1C1CC1
|
CCn1ncc(C[NH2+]C)c1C1CC1
|
CCn1ncc(-c2ncnc3sc-3c(C)c2[NH2+]C)c1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&sc2ncnc&c12",
"old_substring": "C24"
}
|
Can you make molecule CCn1ncc(C[NH2+]C)c1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1ncc(C2=CC=C3SCCN3C([NH2+]C)=C2)c1C1CC1
|
CCn1ncc(C[NH2+]C)c1C1CC1
|
CCn1ncc(C2=CC=C3SCCN3C([NH2+]C)=C2)c1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "C24"
}
|
Can you make molecule CCn1ncc(C[NH2+]C)c1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1ncc(C2=C3CCN3CC([NH2+]C)=CC=C2)c1C1CC1
|
CCn1ncc(C[NH2+]C)c1C1CC1
|
CCn1ncc(C2=C3CCN3CC([NH2+]C)=CC=C2)c1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2c&cccc2C1",
"old_substring": "C24"
}
|
Can you make molecule CCn1ncc(C[NH2+]C)c1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1ncc(-c2ccc([NH2+]C)c(C)c3sc-3n2)c1C1CC1
|
CCn1ncc(C[NH2+]C)c1C1CC1
|
CCn1ncc(-c2ccc([NH2+]C)c(C)c3sc-3n2)c1C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&sc2nc&ccc12",
"old_substring": "C24"
}
|
Can you make molecule CCN(CCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCCCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1
|
CCN(CCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1
|
CCN(CCCCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C6C8"
}
|
Can you make molecule CCN(CCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CCCCCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1
|
CCN(CCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1
|
CCN(CCCCCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C6C8"
}
|
Can you make molecule CCN(CCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C(=O)[C@@H]1CC(=O)N(C2CC2)C1)C1CC(c2nc3ccc(OC)cc3[nH]2)C1
|
CCN(CCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1
|
CCN(C(=O)[C@@H]1CC(=O)N(C2CC2)C1)C1CC(c2nc3ccc(OC)cc3[nH]2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C6C8"
}
|
Can you make molecule CCN(CCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C(=O)[C@@H]1CC(=O)N(C2CC2)C1)[C@@H](C)CCc1nc2ccc(OC)cc2[nH]1
|
CCN(CCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1
|
CCN(C(=O)[C@@H]1CC(=O)N(C2CC2)C1)[C@@H](C)CCc1nc2ccc(OC)cc2[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C6C8"
}
|
Can you make molecule CCN(CCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C(=O)[C@@H]1CC(=O)N(C2CC2)C1)C1CCC(c2nc3ccc(OC)cc3[nH]2)CC1
|
CCN(CCc1nc2ccc(OC)cc2[nH]1)C(=O)[C@@H]1CC(=O)N(C2CC2)C1
|
CCN(C(=O)[C@@H]1CC(=O)N(C2CC2)C1)C1CCC(c2nc3ccc(OC)cc3[nH]2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C6C8"
}
|
Can you make molecule O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2Cl)CC1
|
O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2)CC1
|
O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c14ccccc1"
}
|
Can you make molecule O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccc(I)cc2)CC1
|
O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2)CC1
|
O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccc(I)cc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c14ccccc1"
}
|
Can you make molecule O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(N2CCN(C(=O)Cn3cnc4c(nnn4-c4ccc(F)cc4)c3=O)CC2)cc1I
|
O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2)CC1
|
Cc1ccc(N2CCN(C(=O)Cn3cnc4c(nnn4-c4ccc(F)cc4)c3=O)CC2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c14ccccc1"
}
|
Can you make molecule O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2cccc(Br)c2)CC1
|
O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2)CC1
|
O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2cccc(Br)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c14ccccc1"
}
|
Can you make molecule O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(N2CCN(C(=O)Cn3cnc4c(nnn4-c4ccc(F)cc4)c3=O)CC2)c1C
|
O=C(Cn1cnc2c(nnn2-c2ccc(F)cc2)c1=O)N1CCN(c2ccccc2)CC1
|
Cc1cccc(N2CCN(C(=O)Cn3cnc4c(nnn4-c4ccc(F)cc4)c3=O)CC2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c14ccccc1"
}
|
Can you make molecule Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(N)=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NCCCCC(N)=O)c1
|
Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(N)=O)c1
|
Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NCCCCC(N)=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(N)=O",
"old_substring": "C4(N)=O"
}
|
Can you make molecule Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(N)=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)CN[C@@H](Cc1ccccc1)C(=O)Nc1cncc(C)c1
|
Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(N)=O)c1
|
CC(=O)CN[C@@H](Cc1ccccc1)C(=O)Nc1cncc(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(C)=O",
"old_substring": "C4(N)=O"
}
|
Can you make molecule Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(N)=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CON(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cncc(C)c1
|
Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(N)=O)c1
|
CON(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1cncc(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CON(C)C&=O",
"old_substring": "C4(N)=O"
}
|
Can you make molecule Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(N)=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)C)c1
|
Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(N)=O)c1
|
Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)C&=O",
"old_substring": "C4(N)=O"
}
|
Can you make molecule Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(N)=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(=O)S)c1
|
Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(N)=O)c1
|
Cc1cncc(NC(=O)[C@H](Cc2ccccc2)NC(=O)S)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)S",
"old_substring": "C4(N)=O"
}
|
Can you make molecule O=C(COc1ccccc1Cl)N/N=C1\C(=O)Nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1cc(I)ccc1Cl)N/N=C1\C(=O)Nc2ccccc21
|
O=C(COc1ccccc1Cl)N/N=C1\C(=O)Nc2ccccc21
|
O=C(COc1cc(I)ccc1Cl)N/N=C1\C(=O)Nc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(I)ccc1Cl",
"old_substring": "c14ccccc1Cl"
}
|
Can you make molecule O=C(COc1ccccc1Cl)N/N=C1\C(=O)Nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1cc(Br)ccc1Cl)N/N=C1\C(=O)Nc2ccccc21
|
O=C(COc1ccccc1Cl)N/N=C1\C(=O)Nc2ccccc21
|
O=C(COc1cc(Br)ccc1Cl)N/N=C1\C(=O)Nc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)ccc1Cl",
"old_substring": "c14ccccc1Cl"
}
|
Can you make molecule O=C(COc1ccccc1Cl)N/N=C1\C(=O)Nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1sc2sccc2c1Cl)N/N=C1\C(=O)Nc2ccccc21
|
O=C(COc1ccccc1Cl)N/N=C1\C(=O)Nc2ccccc21
|
O=C(COc1sc2sccc2c1Cl)N/N=C1\C(=O)Nc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sc2sccc2c1Cl",
"old_substring": "c14ccccc1Cl"
}
|
Can you make molecule O=C(COc1ccccc1Cl)N/N=C1\C(=O)Nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1sc2ccccc2c1Cl)N/N=C1\C(=O)Nc2ccccc21
|
O=C(COc1ccccc1Cl)N/N=C1\C(=O)Nc2ccccc21
|
O=C(COc1sc2ccccc2c1Cl)N/N=C1\C(=O)Nc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sc2ccccc2c1Cl",
"old_substring": "c14ccccc1Cl"
}
|
Can you make molecule O=C(COc1ccccc1Cl)N/N=C1\C(=O)Nc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1cc(Br)c(F)cc1Cl)N/N=C1\C(=O)Nc2ccccc21
|
O=C(COc1ccccc1Cl)N/N=C1\C(=O)Nc2ccccc21
|
O=C(COc1cc(Br)c(F)cc1Cl)N/N=C1\C(=O)Nc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)c(F)cc1Cl",
"old_substring": "c14ccccc1Cl"
}
|
Can you make molecule CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](CBr)CCCc2ccccc2)Oc2ccccc21
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](CBr)CCCc2ccccc2)Oc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]4(C)CC7"
}
|
Can you make molecule CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CC(C)(C)Cc2ccccc2)Oc2ccccc21
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CC(C)(C)Cc2ccccc2)Oc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(C)CC(C)(C)C&",
"old_substring": "[C@H]4(C)CC7"
}
|
Can you make molecule CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](CCc2ccccc2)C(C)(C)C)Oc2ccccc21
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](CCc2ccccc2)C(C)(C)C)Oc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC&)C(C)(C)C",
"old_substring": "[C@H]4(C)CC7"
}
|
Can you make molecule CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@H](C)C(C)(C)Cc2ccccc2)Oc2ccccc21
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@H](C)C(C)(C)Cc2ccccc2)Oc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(C)C(C)(C)C&",
"old_substring": "[C@H]4(C)CC7"
}
|
Can you make molecule CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@H](CCl)CCCc2ccccc2)Oc2ccccc21
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21
|
CCS(=O)(=O)N1C[C@H](C(=O)N[C@H](CCl)CCCc2ccccc2)Oc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@H]4(C)CC7"
}
|
Can you make molecule CCc1noc(CC)c1CNC(=O)c1cccc(NC(=O)OC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1noc(CC)c1CSCNC(=O)c1cccc(NC(=O)OC)c1
|
CCc1noc(CC)c1CNC(=O)c1cccc(NC(=O)OC)c1
|
CCc1noc(CC)c1CSCNC(=O)c1cccc(NC(=O)OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N35"
}
|
Can you make molecule CCc1noc(CC)c1CNC(=O)c1cccc(NC(=O)OC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1noc(CC)c1CSC(=N)NC(=O)c1cccc(NC(=O)OC)c1
|
CCc1noc(CC)c1CNC(=O)c1cccc(NC(=O)OC)c1
|
CCc1noc(CC)c1CSC(=N)NC(=O)c1cccc(NC(=O)OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N35"
}
|
Can you make molecule CCc1noc(CC)c1CNC(=O)c1cccc(NC(=O)OC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1noc(CC)c1CSC(=S)N(C)C(=O)c1cccc(NC(=O)OC)c1
|
CCc1noc(CC)c1CNC(=O)c1cccc(NC(=O)OC)c1
|
CCc1noc(CC)c1CSC(=S)N(C)C(=O)c1cccc(NC(=O)OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N35"
}
|
Can you make molecule CCc1noc(CC)c1CNC(=O)c1cccc(NC(=O)OC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1noc(CC)c1Cc1cc(C(=O)c2cccc(NC(=O)OC)c2)oc1N
|
CCc1noc(CC)c1CNC(=O)c1cccc(NC(=O)OC)c1
|
CCc1noc(CC)c1Cc1cc(C(=O)c2cccc(NC(=O)OC)c2)oc1N
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1oc&cc1&",
"old_substring": "N35"
}
|
Can you make molecule CCc1noc(CC)c1CNC(=O)c1cccc(NC(=O)OC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1noc(CC)c1CSC1=NCCN1C(=O)c1cccc(NC(=O)OC)c1
|
CCc1noc(CC)c1CNC(=O)c1cccc(NC(=O)OC)c1
|
CCc1noc(CC)c1CSC1=NCCN1C(=O)c1cccc(NC(=O)OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N35"
}
|
Can you make molecule COc1ccc(NC(=O)c2cccnc2Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(NC(=O)c2cccnc2Cl)cn1
|
COc1ccc(NC(=O)c2cccnc2Cl)cn1
|
COCc1ccc(NC(=O)c2cccnc2Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(NC(=O)c2cccnc2Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(NC(=O)c2cccnc2Cl)cn1
|
COc1ccc(NC(=O)c2cccnc2Cl)cn1
|
COCSc1ccc(NC(=O)c2cccnc2Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(NC(=O)c2cccnc2Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1ccc(NC(=O)c2cccnc2Cl)cn1
|
COc1ccc(NC(=O)c2cccnc2Cl)cn1
|
CC(=O)Sc1ccc(NC(=O)c2cccnc2Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(NC(=O)c2cccnc2Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CS)c1ccc(NC(=O)c2cccnc2Cl)cn1
|
COc1ccc(NC(=O)c2cccnc2Cl)cn1
|
O=C(CS)c1ccc(NC(=O)c2cccnc2Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(NC(=O)c2cccnc2Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CI)c1ccc(NC(=O)c2cccnc2Cl)cn1
|
COc1ccc(NC(=O)c2cccnc2Cl)cn1
|
O=C(CI)c1ccc(NC(=O)c2cccnc2Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO4"
}
|
Can you make molecule C[C@@H](Cc1[nH+]ccn1C)C[C@@H](C)Br less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Cc1[nH+]ccs1)C[C@@H](C)Br
|
C[C@@H](Cc1[nH+]ccn1C)C[C@@H](C)Br
|
C[C@@H](Cc1[nH+]ccs1)C[C@@H](C)Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&[nH+]ccs1",
"old_substring": "c12[nH+]ccn1C"
}
|
Can you make molecule C[C@@H](Cc1[nH+]ccn1C)C[C@@H](C)Br less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Cc1n[nH]c2c1CCC2)C[C@@H](C)Br
|
C[C@@H](Cc1[nH+]ccn1C)C[C@@H](C)Br
|
C[C@@H](Cc1n[nH]c2c1CCC2)C[C@@H](C)Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&n[nH]c2c1CCC2",
"old_substring": "c12[nH+]ccn1C"
}
|
Can you make molecule C[C@@H](Cc1[nH+]ccn1C)C[C@@H](C)Br less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1[nH+]cnc(C[C@H](C)C[C@@H](C)Br)c1C
|
C[C@@H](Cc1[nH+]ccn1C)C[C@@H](C)Br
|
Cc1[nH+]cnc(C[C@H](C)C[C@@H](C)Br)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1[nH+]cnc&c1C",
"old_substring": "c12[nH+]ccn1C"
}
|
Can you make molecule C[C@@H](Cc1[nH+]ccn1C)C[C@@H](C)Br less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Cc1n[nH]c2c1CCCCC2)C[C@@H](C)Br
|
C[C@@H](Cc1[nH+]ccn1C)C[C@@H](C)Br
|
C[C@@H](Cc1n[nH]c2c1CCCCC2)C[C@@H](C)Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&n[nH]c2c1CCCCC2",
"old_substring": "c12[nH+]ccn1C"
}
|
Can you make molecule C[C@@H](Cc1[nH+]ccn1C)C[C@@H](C)Br less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1[nH]nc(C[C@H](C)C[C@@H](C)Br)c1C
|
C[C@@H](Cc1[nH+]ccn1C)C[C@@H](C)Br
|
Cc1[nH]nc(C[C@H](C)C[C@@H](C)Br)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1[nH]nc&c1C",
"old_substring": "c12[nH+]ccn1C"
}
|
Can you make molecule Cn1cc(C[NH2+]CCSc2ccccc2F)c(-c2cccs2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C[NH2+]CCSc2ccc(I)cc2F)c(-c2cccs2)n1
|
Cn1cc(C[NH2+]CCSc2ccccc2F)c(-c2cccs2)n1
|
Cn1cc(C[NH2+]CCSc2ccc(I)cc2F)c(-c2cccs2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1F",
"old_substring": "c17ccccc1F"
}
|
Can you make molecule Cn1cc(C[NH2+]CCSc2ccccc2F)c(-c2cccs2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C[NH2+]CCSc2cc(I)ccc2F)c(-c2cccs2)n1
|
Cn1cc(C[NH2+]CCSc2ccccc2F)c(-c2cccs2)n1
|
Cn1cc(C[NH2+]CCSc2cc(I)ccc2F)c(-c2cccs2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(I)ccc1F",
"old_substring": "c17ccccc1F"
}
|
Can you make molecule Cn1cc(C[NH2+]CCSc2ccccc2F)c(-c2cccs2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C[NH2+]CCSc2ccccc2Cl)c(-c2cccs2)n1
|
Cn1cc(C[NH2+]CCSc2ccccc2F)c(-c2cccs2)n1
|
Cn1cc(C[NH2+]CCSc2ccccc2Cl)c(-c2cccs2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c17ccccc1F"
}
|
Can you make molecule Cn1cc(C[NH2+]CCSc2ccccc2F)c(-c2cccs2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C[NH2+]CCSc2cc(F)ccc2Br)c(-c2cccs2)n1
|
Cn1cc(C[NH2+]CCSc2ccccc2F)c(-c2cccs2)n1
|
Cn1cc(C[NH2+]CCSc2cc(F)ccc2Br)c(-c2cccs2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1Br",
"old_substring": "c17ccccc1F"
}
|
Can you make molecule Cn1cc(C[NH2+]CCSc2ccccc2F)c(-c2cccs2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(C[NH2+]CCSc2ccc(F)cc2Cl)c(-c2cccs2)n1
|
Cn1cc(C[NH2+]CCSc2ccccc2F)c(-c2cccs2)n1
|
Cn1cc(C[NH2+]CCSc2ccc(F)cc2Cl)c(-c2cccs2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c17ccccc1F"
}
|
Can you make molecule CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2)nc1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2Cl)nc1[O-]
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2)nc1[O-]
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2Cl)nc1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(C)cc1Cl",
"old_substring": "c17ccc(C)cc1"
}
|
Can you make molecule CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2)nc1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(Cl)cc2I)nc1[O-]
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2)nc1[O-]
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(Cl)cc2I)nc1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1I",
"old_substring": "c17ccc(C)cc1"
}
|
Can you make molecule CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2)nc1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(Cl)cc2Br)nc1[O-]
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2)nc1[O-]
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(Cl)cc2Br)nc1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1Br",
"old_substring": "c17ccc(C)cc1"
}
|
Can you make molecule CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2)nc1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2cc(C)c(I)cc2C)nc1[O-]
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2)nc1[O-]
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2cc(C)c(I)cc2C)nc1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&c(C)cc1I",
"old_substring": "c17ccc(C)cc1"
}
|
Can you make molecule CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2)nc1[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(Cl)c(I)c2)nc1[O-]
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(C)cc2)nc1[O-]
|
CCOC(=O)c1cc(C#N)c(SCC(=O)c2ccc(Cl)c(I)c2)nc1[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(I)c1",
"old_substring": "c17ccc(C)cc1"
}
|
Can you make molecule COc1ccc(NC(=O)c2ccc(C)nc2)cc1NS(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(NC(=O)c2ccc(Cl)nc2C)cc1NS(C)(=O)=O
|
COc1ccc(NC(=O)c2ccc(C)nc2)cc1NS(C)(=O)=O
|
COc1ccc(NC(=O)c2ccc(Cl)nc2C)cc1NS(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)nc1C",
"old_substring": "c18ccc(C)nc1"
}
|
Can you make molecule COc1ccc(NC(=O)c2ccc(C)nc2)cc1NS(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(NC(=O)c2ncc(Cl)cc2F)cc1NS(C)(=O)=O
|
COc1ccc(NC(=O)c2ccc(C)nc2)cc1NS(C)(=O)=O
|
COc1ccc(NC(=O)c2ncc(Cl)cc2F)cc1NS(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc(Cl)cc1F",
"old_substring": "c18ccc(C)nc1"
}
|
Can you make molecule COc1ccc(NC(=O)c2ccc(C)nc2)cc1NS(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(NC(=O)c2cnc(Cl)cc2I)cc1NS(C)(=O)=O
|
COc1ccc(NC(=O)c2ccc(C)nc2)cc1NS(C)(=O)=O
|
COc1ccc(NC(=O)c2cnc(Cl)cc2I)cc1NS(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cnc(Cl)cc1I",
"old_substring": "c18ccc(C)nc1"
}
|
Can you make molecule COc1ccc(NC(=O)c2ccc(C)nc2)cc1NS(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(NC(=O)n2c(C)ccc2C)cc1NS(C)(=O)=O
|
COc1ccc(NC(=O)c2ccc(C)nc2)cc1NS(C)(=O)=O
|
COc1ccc(NC(=O)n2c(C)ccc2C)cc1NS(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(C)n1&",
"old_substring": "c18ccc(C)nc1"
}
|
Can you make molecule COc1ccc(NC(=O)c2ccc(C)nc2)cc1NS(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(NC(=O)c2ccc(C)s2)cc1NS(C)(=O)=O
|
COc1ccc(NC(=O)c2ccc(C)nc2)cc1NS(C)(=O)=O
|
COc1ccc(NC(=O)c2ccc(C)s2)cc1NS(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(C)s1",
"old_substring": "c18ccc(C)nc1"
}
|
Can you make molecule CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1I
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17ccc6cc1"
}
|
Can you make molecule CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1cc(C(F)(F)F)ccc1Br
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1cc(C(F)(F)F)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17ccc6cc1"
}
|
Can you make molecule CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1Cl
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17ccc6cc1"
}
|
Can you make molecule CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1cccc(C(F)(F)F)c1Br
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1cccc(C(F)(F)F)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17ccc6cc1"
}
|
Can you make molecule CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1cccc(C(F)(F)F)c1Cl
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1ccc(C(F)(F)F)cc1
|
CN(Cc1cnn(C)c1)C(=O)c1ccccc1-c1cccc(C(F)(F)F)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17ccc6cc1"
}
|
Can you make molecule CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
|
CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
|
C=CSOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC5"
}
|
Can you make molecule CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
|
CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
|
C=CCCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC5"
}
|
Can you make molecule CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(OCCCCl)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
|
CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
|
O=C(OCCCCl)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC5"
}
|
Can you make molecule CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(OCCCCS)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
|
CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
|
O=C(OCCCCS)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC5"
}
|
Can you make molecule CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(OCCCBr)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
|
CCOC(=O)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
|
O=C(OCCCBr)C1=NN(c2ccccc2)[C@H](C(=O)NCC(F)(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC5"
}
|
Can you make molecule C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)c1cccc2ncccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1SC(=O)Cc1cccc2ncccc12
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)c1cccc2ncccc12
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1SC(=O)Cc1cccc2ncccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C58=O"
}
|
Can you make molecule C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)c1cccc2ncccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)CCCC(=O)c1cccc2ncccc12
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)c1cccc2ncccc12
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)CCCC(=O)c1cccc2ncccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C58=O"
}
|
Can you make molecule C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)c1cccc2ncccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)CC(C)(C)c1cccc2ncccc12
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)c1cccc2ncccc12
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)CC(C)(C)c1cccc2ncccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C58=O"
}
|
Can you make molecule C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)c1cccc2ncccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)CCC(C)(C)c1cccc2ncccc12
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)c1cccc2ncccc12
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)CCC(C)(C)c1cccc2ncccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C58=O"
}
|
Can you make molecule C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)c1cccc2ncccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SN1C[C@H](C)N(C(=O)OC(C)(C)C)C[C@H]1C)c1cccc2ncccc12
|
C[C@@H]1CN(C(=O)OC(C)(C)C)[C@@H](C)CN1C(=O)c1cccc2ncccc12
|
C[C@H](C(=O)SN1C[C@H](C)N(C(=O)OC(C)(C)C)C[C@H]1C)c1cccc2ncccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C58=O"
}
|
Can you make molecule CC[C@H]1S/C(=N\c2cccc(C(F)(F)F)c2)NC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H]1S/C(=N\c2cccc(SC(F)(F)F)c2)NC1=O
|
CC[C@H]1S/C(=N\c2cccc(C(F)(F)F)c2)NC1=O
|
CC[C@H]1S/C(=N\c2cccc(SC(F)(F)F)c2)NC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C4(F)(F)F"
}
|
Can you make molecule CC[C@H]1S/C(=N\c2cccc(C(F)(F)F)c2)NC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H]1S/C(=N\c2cccc(CCCC(F)(F)F)c2)NC1=O
|
CC[C@H]1S/C(=N\c2cccc(C(F)(F)F)c2)NC1=O
|
CC[C@H]1S/C(=N\c2cccc(CCCC(F)(F)F)c2)NC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C4(F)(F)F"
}
|
Can you make molecule CC[C@H]1S/C(=N\c2cccc(C(F)(F)F)c2)NC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H]1S/C(=N\c2cccc(CCCCC(F)(F)F)c2)NC1=O
|
CC[C@H]1S/C(=N\c2cccc(C(F)(F)F)c2)NC1=O
|
CC[C@H]1S/C(=N\c2cccc(CCCCC(F)(F)F)c2)NC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C4(F)(F)F"
}
|
Can you make molecule CC[C@H]1S/C(=N\c2cccc(C(F)(F)F)c2)NC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H]1S/C(=N\c2cccc(C(F)(F)C(F)(F)F)c2)NC1=O
|
CC[C@H]1S/C(=N\c2cccc(C(F)(F)F)c2)NC1=O
|
CC[C@H]1S/C(=N\c2cccc(C(F)(F)C(F)(F)F)c2)NC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(F)(F)C(F)(F)F",
"old_substring": "C4(F)(F)F"
}
|
Can you make molecule CC[C@H]1S/C(=N\c2cccc(C(F)(F)F)c2)NC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H]1S/C(=N\c2cccc(CC(F)(F)C(F)(F)F)c2)NC1=O
|
CC[C@H]1S/C(=N\c2cccc(C(F)(F)F)c2)NC1=O
|
CC[C@H]1S/C(=N\c2cccc(CC(F)(F)C(F)(F)F)c2)NC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)(F)F",
"old_substring": "C4(F)(F)F"
}
|
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