prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule C[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc2c([O-])n[nH]c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCc2sc(S(=O)(=O)c3ccc4c([O-])n[nH]c(=O)c4c3)cc2C1
|
C[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc2c([O-])n[nH]c(=O)c2c1
|
C[C@H]1CCc2sc(S(=O)(=O)c3ccc4c([O-])n[nH]c(=O)c4c3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1CCc2sc&cc2C1",
"old_substring": "C[C@@H]1Cc2ccccc2N13"
}
|
Can you make molecule C[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc2c([O-])n[nH]c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCc2c(S(=O)(=O)c3ccc4c([O-])n[nH]c(=O)c4c3)csc2C1
|
C[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc2c([O-])n[nH]c(=O)c2c1
|
C[C@H]1CCc2c(S(=O)(=O)c3ccc4c([O-])n[nH]c(=O)c4c3)csc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1CCc2c&csc2C1",
"old_substring": "C[C@@H]1Cc2ccccc2N13"
}
|
Can you make molecule C[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc2c([O-])n[nH]c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(S(=O)(=O)c2ccc3c([O-])n[nH]c(=O)c3c2)Cc2ccccc2C1
|
C[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc2c([O-])n[nH]c(=O)c2c1
|
CC1(S(=O)(=O)c2ccc3c([O-])n[nH]c(=O)c3c2)Cc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1&Cc2ccccc2C1",
"old_substring": "C[C@@H]1Cc2ccccc2N13"
}
|
Can you make molecule C[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc2c([O-])n[nH]c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1[nH]nc([O-])c2ccc(S(=O)(=O)[C@H]3Cc4ccccc4S3)cc12
|
C[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc2c([O-])n[nH]c(=O)c2c1
|
O=c1[nH]nc([O-])c2ccc(S(=O)(=O)[C@H]3Cc4ccccc4S3)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&Cc2ccccc2S1",
"old_substring": "C[C@@H]1Cc2ccccc2N13"
}
|
Can you make molecule C[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc2c([O-])n[nH]c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CN(S(=O)(=O)c2ccc3c([O-])n[nH]c(=O)c3c2)c2ccccc2S1
|
C[C@@H]1Cc2ccccc2N1S(=O)(=O)c1ccc2c([O-])n[nH]c(=O)c2c1
|
CC1(C)CN(S(=O)(=O)c2ccc3c([O-])n[nH]c(=O)c3c2)c2ccccc2S1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1(C)CN&c2ccccc2S1",
"old_substring": "C[C@@H]1Cc2ccccc2N13"
}
|
Can you make molecule NC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)CCCc1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1
|
NC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1
|
NC(=O)CCCc1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "NC(=O)CCC&",
"old_substring": "NC5=O"
}
|
Can you make molecule NC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1CCCN(c2cccc(CC[NH2+][C@@H]3CCC[C@@H]3c3ccc(F)cc3)c2)C1
|
NC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1
|
O=C1CCCN(c2cccc(CC[NH2+][C@@H]3CCC[C@@H]3c3ccc(F)cc3)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC(=O)C1",
"old_substring": "NC5=O"
}
|
Can you make molecule NC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1
|
NC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1
|
CCC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&=O",
"old_substring": "NC5=O"
}
|
Can you make molecule NC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=CC1CCN(c2cccc(CC[NH2+][C@@H]3CCC[C@@H]3c3ccc(F)cc3)c2)CC1
|
NC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1
|
O=CC1CCN(c2cccc(CC[NH2+][C@@H]3CCC[C@@H]3c3ccc(F)cc3)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC(C=O)CC1",
"old_substring": "NC5=O"
}
|
Can you make molecule NC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1CSC(=S)N1c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1
|
NC(=O)c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1
|
O=C1CSC(=S)N1c1cccc(CC[NH2+][C@@H]2CCC[C@@H]2c2ccc(F)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&C(=O)CSC1=S",
"old_substring": "NC5=O"
}
|
Can you make molecule COC[C@@H](C)NC(=O)N[C@@H](C(N)=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@@H](C)NC(=O)N[C@@H]1CCCN(c2ccccc2)C1=O
|
COC[C@@H](C)NC(=O)N[C@@H](C(N)=O)c1ccccc1
|
COC[C@@H](C)NC(=O)N[C@@H]1CCCN(c2ccccc2)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCN&C1=O",
"old_substring": "[C@@H]67C(N)=O"
}
|
Can you make molecule COC[C@@H](C)NC(=O)N[C@@H](C(N)=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@@H](C)NC(=O)N[C@H](C)N(C)Oc1ccccc1
|
COC[C@@H](C)NC(=O)N[C@@H](C(N)=O)c1ccccc1
|
COC[C@@H](C)NC(=O)N[C@H](C)N(C)Oc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(C)N(C)O&",
"old_substring": "[C@@H]67C(N)=O"
}
|
Can you make molecule COC[C@@H](C)NC(=O)N[C@@H](C(N)=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@@H](C)NC(=O)N[C@@H]1C=C(Cc2ccccc2)N=N1
|
COC[C@@H](C)NC(=O)N[C@@H](C(N)=O)c1ccccc1
|
COC[C@@H](C)NC(=O)N[C@@H]1C=C(Cc2ccccc2)N=N1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&C=C(C&)N=N1",
"old_substring": "[C@@H]67C(N)=O"
}
|
Can you make molecule COC[C@@H](C)NC(=O)N[C@@H](C(N)=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@@H](C)NC(=O)N[C@@H]1CCCCN(c2ccccc2)C1=O
|
COC[C@@H](C)NC(=O)N[C@@H](C(N)=O)c1ccccc1
|
COC[C@@H](C)NC(=O)N[C@@H]1CCCCN(c2ccccc2)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCCN&C1=O",
"old_substring": "[C@@H]67C(N)=O"
}
|
Can you make molecule COC[C@@H](C)NC(=O)N[C@@H](C(N)=O)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@@H](C)NC(=O)N[C@H]1CC(Cc2ccccc2)=NO1
|
COC[C@@H](C)NC(=O)N[C@@H](C(N)=O)c1ccccc1
|
COC[C@@H](C)NC(=O)N[C@H]1CC(Cc2ccccc2)=NO1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC(C&)=NO1",
"old_substring": "[C@@H]67C(N)=O"
}
|
Can you make molecule Cc1ccc(CN(C)C(=O)c2cnn3cccnc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN(C)SC(=O)Cc2cnn3cccnc23)cc1
|
Cc1ccc(CN(C)C(=O)c2cnn3cccnc23)cc1
|
Cc1ccc(CN(C)SC(=O)Cc2cnn3cccnc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1ccc(CN(C)C(=O)c2cnn3cccnc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN(C)C(=O)CCCC(=O)c2cnn3cccnc23)cc1
|
Cc1ccc(CN(C)C(=O)c2cnn3cccnc23)cc1
|
Cc1ccc(CN(C)C(=O)CCCC(=O)c2cnn3cccnc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1ccc(CN(C)C(=O)c2cnn3cccnc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN(C)C(=O)CC(C)(C)c2cnn3cccnc23)cc1
|
Cc1ccc(CN(C)C(=O)c2cnn3cccnc23)cc1
|
Cc1ccc(CN(C)C(=O)CC(C)(C)c2cnn3cccnc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1ccc(CN(C)C(=O)c2cnn3cccnc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN(C)C(=O)CCC(C)(C)c2cnn3cccnc23)cc1
|
Cc1ccc(CN(C)C(=O)c2cnn3cccnc23)cc1
|
Cc1ccc(CN(C)C(=O)CCC(C)(C)c2cnn3cccnc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1ccc(CN(C)C(=O)c2cnn3cccnc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN(C)SC(=O)[C@@H](C)c2cnn3cccnc23)cc1
|
Cc1ccc(CN(C)C(=O)c2cnn3cccnc23)cc1
|
Cc1ccc(CN(C)SC(=O)[C@@H](C)c2cnn3cccnc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C46=O"
}
|
Can you make molecule O=C(NC1(c2cccc(F)c2)CCOCC1)c1ccc2ncccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sc1ccc2ncccc2c1)NC1(c2cccc(F)c2)CCOCC1
|
O=C(NC1(c2cccc(F)c2)CCOCC1)c1ccc2ncccc2c1
|
O=C(/C=C/Sc1ccc2ncccc2c1)NC1(c2cccc(F)c2)CCOCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(NC1(c2cccc(F)c2)CCOCC1)c1ccc2ncccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(NC2(c3cccc(F)c3)CCOCC2)nc1-c1ccc2ncccc2c1
|
O=C(NC1(c2cccc(F)c2)CCOCC1)c1ccc2ncccc2c1
|
O=Cc1sc(NC2(c3cccc(F)c3)CCOCC2)nc1-c1ccc2ncccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(NC1(c2cccc(F)c2)CCOCC1)c1ccc2ncccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(NC2(c3cccc(F)c3)CCOCC2)sc1-c1ccc2ncccc2c1
|
O=C(NC1(c2cccc(F)c2)CCOCC1)c1ccc2ncccc2c1
|
O=Cc1nc(NC2(c3cccc(F)c3)CCOCC2)sc1-c1ccc2ncccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(NC1(c2cccc(F)c2)CCOCC1)c1ccc2ncccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC1(c2cccc(F)c2)CCOCC1)n1nc(-c2ccc3ncccc3c2)oc1=S
|
O=C(NC1(c2cccc(F)c2)CCOCC1)c1ccc2ncccc2c1
|
O=C(NC1(c2cccc(F)c2)CCOCC1)n1nc(-c2ccc3ncccc3c2)oc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&n1nc&oc1=S",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(NC1(c2cccc(F)c2)CCOCC1)c1ccc2ncccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1cccc(C2(NO/N=C/c3ccc(-c4ccc5ncccc5c4)o3)CCOCC2)c1
|
O=C(NC1(c2cccc(F)c2)CCOCC1)c1ccc2ncccc2c1
|
Fc1cccc(C2(NO/N=C/c3ccc(-c4ccc5ncccc5c4)o3)CCOCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C35"
}
|
Can you make molecule CCn1nccc1CN(C)C(=O)c1ccc(COc2ccc3c(c2)OCO3)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nccc1Cc1sc(C(=O)c2ccc(COc3ccc4c(c3)OCO4)o2)cc1C#N
|
CCn1nccc1CN(C)C(=O)c1ccc(COc2ccc3c(c2)OCO3)o1
|
CCn1nccc1Cc1sc(C(=O)c2ccc(COc3ccc4c(c3)OCO4)o2)cc1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N47C"
}
|
Can you make molecule CCn1nccc1CN(C)C(=O)c1ccc(COc2ccc3c(c2)OCO3)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nccc1Cc1ccc(C(=O)c2ccc(COc3ccc4c(c3)OCO4)o2)cc1C#N
|
CCn1nccc1CN(C)C(=O)c1ccc(COc2ccc3c(c2)OCO3)o1
|
CCn1nccc1Cc1ccc(C(=O)c2ccc(COc3ccc4c(c3)OCO4)o2)cc1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N47C"
}
|
Can you make molecule CCn1nccc1CN(C)C(=O)c1ccc(COc2ccc3c(c2)OCO3)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nccc1CN1CCC(=NOC(=O)c2ccc(COc3ccc4c(c3)OCO4)o2)CC1
|
CCn1nccc1CN(C)C(=O)c1ccc(COc2ccc3c(c2)OCO3)o1
|
CCn1nccc1CN1CCC(=NOC(=O)c2ccc(COc3ccc4c(c3)OCO4)o2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "N47C"
}
|
Can you make molecule CCn1nccc1CN(C)C(=O)c1ccc(COc2ccc3c(c2)OCO3)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nccc1Cc1cc(C(=O)c2ccc(COc3ccc4c(c3)OCO4)o2)cnc1C#N
|
CCn1nccc1CN(C)C(=O)c1ccc(COc2ccc3c(c2)OCO3)o1
|
CCn1nccc1Cc1cc(C(=O)c2ccc(COc3ccc4c(c3)OCO4)o2)cnc1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1ncc&cc1&",
"old_substring": "N47C"
}
|
Can you make molecule CCn1nccc1CN(C)C(=O)c1ccc(COc2ccc3c(c2)OCO3)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1nccc1CCC1=CCCN(C(=O)c2ccc(COc3ccc4c(c3)OCO4)o2)C1
|
CCn1nccc1CN(C)C(=O)c1ccc(COc2ccc3c(c2)OCO3)o1
|
CCn1nccc1CCC1=CCCN(C(=O)c2ccc(COc3ccc4c(c3)OCO4)o2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC=C(C&)C1",
"old_substring": "N47C"
}
|
Can you make molecule COC(=O)c1c(NC(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1c(SC(=S)N(C)C(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C
|
COC(=O)c1c(NC(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C
|
COC(=O)c1c(SC(=S)N(C)C(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N48"
}
|
Can you make molecule COC(=O)c1c(NC(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1c(SC2=NCCN2C(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C
|
COC(=O)c1c(NC(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C
|
COC(=O)c1c(SC2=NCCN2C(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N48"
}
|
Can you make molecule COC(=O)c1c(NC(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1c(C2CCN(CC(=O)c3cccc(OC)c3)CC2)sc(C(=O)NC(C)C)c1C
|
COC(=O)c1c(NC(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C
|
COC(=O)c1c(C2CCN(CC(=O)c3cccc(OC)c3)CC2)sc(C(=O)NC(C)C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N48"
}
|
Can you make molecule COC(=O)c1c(NC(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1c(-c2cccc(C(=O)c3cccc(OC)c3)c2N)sc(C(=O)NC(C)C)c1C
|
COC(=O)c1c(NC(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C
|
COC(=O)c1c(-c2cccc(C(=O)c3cccc(OC)c3)c2N)sc(C(=O)NC(C)C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&cccc1&",
"old_substring": "N48"
}
|
Can you make molecule COC(=O)c1c(NC(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)c1c(-c2cc(N)cc(C(=O)c3cccc(OC)c3)c2)sc(C(=O)NC(C)C)c1C
|
COC(=O)c1c(NC(=O)c2cccc(OC)c2)sc(C(=O)NC(C)C)c1C
|
COC(=O)c1c(-c2cc(N)cc(C(=O)c3cccc(OC)c3)c2)sc(C(=O)NC(C)C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1cc&cc&c1",
"old_substring": "N48"
}
|
Can you make molecule CC(C)(CNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](CCNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1
|
CC(C)(CNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1
|
CC(C)[C@H](CCNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)[C@@H]&CC&",
"old_substring": "CC6(C)C4"
}
|
Can you make molecule CC(C)(CNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#CC(C#N)=C(SNC(=O)c1cccc(N2CCCNC2=O)c1)Sc1ccncc1
|
CC(C)(CNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1
|
N#CC(C#N)=C(SNC(=O)c1cccc(N2CCCNC2=O)c1)Sc1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#CC(C#N)=C(S&)S&",
"old_substring": "CC6(C)C4"
}
|
Can you make molecule CC(C)(CNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C#CC#CC(C)(C)c1ccncc1)NC(=O)c1cccc(N2CCCNC2=O)c1
|
CC(C)(CNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1
|
CC(C)(C#CC#CC(C)(C)c1ccncc1)NC(=O)c1cccc(N2CCCNC2=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC&(C)C#CC#CC&(C)C",
"old_substring": "CC6(C)C4"
}
|
Can you make molecule CC(C)(CNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=C(C)[C@](C)(C#CCNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1
|
CC(C)(CNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1
|
C=C(C)[C@](C)(C#CCNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C(C)[C@]&(C)C#CC&",
"old_substring": "CC6(C)C4"
}
|
Can you make molecule CC(C)(CNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(NC(=O)c2cccc(N3CCCNC3=O)c2)CCC(c2ccncc2)CC1
|
CC(C)(CNC(=O)c1cccc(N2CCCNC2=O)c1)c1ccncc1
|
CC1(NC(=O)c2cccc(N3CCCNC3=O)c2)CCC(c2ccncc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&(C)CC1",
"old_substring": "CC6(C)C4"
}
|
Can you make molecule COc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
|
COc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
|
COCc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
|
COc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
|
COCSc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
|
COc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
|
CC(=O)Sc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](C)NC(=O)c1noc2c1CCc1ccc(C(=O)CS)cc1-2
|
COc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
|
CC(C)[C@@H](C)NC(=O)c1noc2c1CCc1ccc(C(=O)CS)cc1-2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](C)NC(=O)c1noc2c1CCc1ccc(C(=O)CI)cc1-2
|
COc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
|
CC(C)[C@@H](C)NC(=O)c1noc2c1CCc1ccc(C(=O)CI)cc1-2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO4"
}
|
Can you make molecule Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc2sccn2c1CN1CCO[C@H](c2ccc(I)cc2F)C1
|
Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2F)C1
|
Cc1nc2sccn2c1CN1CCO[C@H](c2ccc(I)cc2F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1F",
"old_substring": "c15ccccc1F"
}
|
Can you make molecule Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc2sccn2c1CN1CCO[C@H](c2cc(I)ccc2F)C1
|
Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2F)C1
|
Cc1nc2sccn2c1CN1CCO[C@H](c2cc(I)ccc2F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(I)ccc1F",
"old_substring": "c15ccccc1F"
}
|
Can you make molecule Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2Cl)C1
|
Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2F)C1
|
Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c15ccccc1F"
}
|
Can you make molecule Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc2sccn2c1CN1CCO[C@H](c2cc(F)ccc2Br)C1
|
Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2F)C1
|
Cc1nc2sccn2c1CN1CCO[C@H](c2cc(F)ccc2Br)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1Br",
"old_substring": "c15ccccc1F"
}
|
Can you make molecule Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc2sccn2c1CN1CCO[C@H](c2ccc(F)cc2Cl)C1
|
Cc1nc2sccn2c1CN1CCO[C@H](c2ccccc2F)C1
|
Cc1nc2sccn2c1CN1CCO[C@H](c2ccc(F)cc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c15ccccc1F"
}
|
Can you make molecule O=C(c1cccnc1)N1CCN(Cc2ccon2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sc1cccnc1)N1CCN(Cc2ccon2)CC1
|
O=C(c1cccnc1)N1CCN(Cc2ccon2)CC1
|
O=C(/C=C/Sc1cccnc1)N1CCN(Cc2ccon2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(c1cccnc1)N1CCN(Cc2ccon2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(N2CCN(Cc3ccon3)CC2)nc1-c1cccnc1
|
O=C(c1cccnc1)N1CCN(Cc2ccon2)CC1
|
O=Cc1sc(N2CCN(Cc3ccon3)CC2)nc1-c1cccnc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(c1cccnc1)N1CCN(Cc2ccon2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(N2CCN(Cc3ccon3)CC2)sc1-c1cccnc1
|
O=C(c1cccnc1)N1CCN(Cc2ccon2)CC1
|
O=Cc1nc(N2CCN(Cc3ccon3)CC2)sc1-c1cccnc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(c1cccnc1)N1CCN(Cc2ccon2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(N1CCN(Cc2ccon2)CC1)n1nc(-c2cccnc2)oc1=S
|
O=C(c1cccnc1)N1CCN(Cc2ccon2)CC1
|
O=C(N1CCN(Cc2ccon2)CC1)n1nc(-c2cccnc2)oc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&n1nc&oc1=S",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(c1cccnc1)N1CCN(Cc2ccon2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C(=N/ON1CCN(Cc2ccon2)CC1)\c1ccc(-c2cccnc2)o1
|
O=C(c1cccnc1)N1CCN(Cc2ccon2)CC1
|
C(=N/ON1CCN(Cc2ccon2)CC1)\c1ccc(-c2cccnc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C35"
}
|
Can you make molecule CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)NCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)CC(=O)SNCc1ccccc1
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)NCc1ccccc1
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)CC(=O)SNCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C25=O"
}
|
Can you make molecule CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)NCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)CC(=C=O)CNCc1ccccc1
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)NCc1ccccc1
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)CC(=C=O)CNCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C25=O"
}
|
Can you make molecule CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)NCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)CCCC(=O)NCc1ccccc1
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)NCc1ccccc1
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)CCCC(=O)NCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C25=O"
}
|
Can you make molecule CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)NCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)NCc1ccccc1)[C@]1(C)CC[C@@H](C(=O)[O-])C1(C)C
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)NCc1ccccc1
|
CC(C)(CC(=O)NCc1ccccc1)[C@]1(C)CC[C@@H](C(=O)[O-])C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C25=O"
}
|
Can you make molecule CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)NCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)CCC[S@@+]([O-])CNCc1ccccc1
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)C(=O)NCc1ccccc1
|
CC1(C)[C@H](C(=O)[O-])CC[C@@]1(C)CCC[S@@+]([O-])CNCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C25=O"
}
|
Can you make molecule CCCc1cnc(C)nc1N1CCC([NH2+]C[C@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cnc(C)nc1N1CCC([NH2+]C[C@@H](C)C(=O)c2ccccc2)CC1
|
CCCc1cnc(C)nc1N1CCC([NH2+]C[C@H](O)c2ccccc2)CC1
|
CCCc1cnc(C)nc1N1CCC([NH2+]C[C@@H](C)C(=O)c2ccccc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[C@@H](C)C&=O",
"old_substring": "C3[C@@H]7O"
}
|
Can you make molecule CCCc1cnc(C)nc1N1CCC([NH2+]C[C@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cnc(C)nc1N1CCC([NH2+]CC[C@H](C)CC(=O)c2ccccc2)CC1
|
CCCc1cnc(C)nc1N1CCC([NH2+]C[C@H](O)c2ccccc2)CC1
|
CCCc1cnc(C)nc1N1CCC([NH2+]CC[C@H](C)CC(=O)c2ccccc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C3[C@@H]7O"
}
|
Can you make molecule CCCc1cnc(C)nc1N1CCC([NH2+]C[C@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cnc(C)nc1N1CCC([NH2+]C[C@@H](O)C(C)(C)c2ccccc2)CC1
|
CCCc1cnc(C)nc1N1CCC([NH2+]C[C@H](O)c2ccccc2)CC1
|
CCCc1cnc(C)nc1N1CCC([NH2+]C[C@@H](O)C(C)(C)c2ccccc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[C@@H](O)C&(C)C",
"old_substring": "C3[C@@H]7O"
}
|
Can you make molecule CCCc1cnc(C)nc1N1CCC([NH2+]C[C@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cnc(C)nc1N1CCC([NH2+][C@H](CC)CC(=O)c2ccccc2)CC1
|
CCCc1cnc(C)nc1N1CCC([NH2+]C[C@H](O)c2ccccc2)CC1
|
CCCc1cnc(C)nc1N1CCC([NH2+][C@H](CC)CC(=O)c2ccccc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H]&CC&=O",
"old_substring": "C3[C@@H]7O"
}
|
Can you make molecule CCCc1cnc(C)nc1N1CCC([NH2+]C[C@H](O)c2ccccc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cnc(C)nc1N1CCC([NH2+]C(=O)C[C@H](C)C(=O)c2ccccc2)CC1
|
CCCc1cnc(C)nc1N1CCC([NH2+]C[C@H](O)c2ccccc2)CC1
|
CCCc1cnc(C)nc1N1CCC([NH2+]C(=O)C[C@H](C)C(=O)c2ccccc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&=O)C&=O",
"old_substring": "C3[C@@H]7O"
}
|
Can you make molecule CC(=O)c1ccc2nc(N)sc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)c1ccc2nc(N)sc2c1
|
CC(=O)c1ccc2nc(N)sc2c1
|
CCCC(=O)c1ccc2nc(N)sc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&=O",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)c1ccc2nc(N)sc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)c1ccc2nc(N)sc2c1
|
CC(=O)c1ccc2nc(N)sc2c1
|
CCCCC(=O)c1ccc2nc(N)sc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)c1ccc2nc(N)sc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)CCCc1ccc2nc(N)sc2c1
|
CC(=O)c1ccc2nc(N)sc2c1
|
CC(=O)CCCc1ccc2nc(N)sc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)CCC&",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)c1ccc2nc(N)sc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)CCCc1ccc2nc(N)sc2c1
|
CC(=O)c1ccc2nc(N)sc2c1
|
CCC(=O)CCCc1ccc2nc(N)sc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(=O)CCC&",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)c1ccc2nc(N)sc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)Cc1ccc2nc(N)sc2c1
|
CC(=O)c1ccc2nc(N)sc2c1
|
CCCCC(=O)Cc1ccc2nc(N)sc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC(=O)C&",
"old_substring": "CC3=O"
}
|
Can you make molecule C[C@H]1OCC[C@@H]1C(=O)Nc1ccc(C#N)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1OCC[C@@H]1CC(=O)SNc1ccc(C#N)cn1
|
C[C@H]1OCC[C@@H]1C(=O)Nc1ccc(C#N)cn1
|
C[C@H]1OCC[C@@H]1CC(=O)SNc1ccc(C#N)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule C[C@H]1OCC[C@@H]1C(=O)Nc1ccc(C#N)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1OCC[C@@H]1CC(=C=O)CNc1ccc(C#N)cn1
|
C[C@H]1OCC[C@@H]1C(=O)Nc1ccc(C#N)cn1
|
C[C@H]1OCC[C@@H]1CC(=C=O)CNc1ccc(C#N)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule C[C@H]1OCC[C@@H]1C(=O)Nc1ccc(C#N)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1OCC[C@@H]1C(=O)CCCC(=O)Nc1ccc(C#N)cn1
|
C[C@H]1OCC[C@@H]1C(=O)Nc1ccc(C#N)cn1
|
C[C@H]1OCC[C@@H]1C(=O)CCCC(=O)Nc1ccc(C#N)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C24=O"
}
|
Can you make molecule C[C@H]1OCC[C@@H]1C(=O)Nc1ccc(C#N)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1OCC[C@@H]1C(C)(C)CC(=O)Nc1ccc(C#N)cn1
|
C[C@H]1OCC[C@@H]1C(=O)Nc1ccc(C#N)cn1
|
C[C@H]1OCC[C@@H]1C(C)(C)CC(=O)Nc1ccc(C#N)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule C[C@H]1OCC[C@@H]1C(=O)Nc1ccc(C#N)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1OCC[C@@H]1CCC[S@@+]([O-])CNc1ccc(C#N)cn1
|
C[C@H]1OCC[C@@H]1C(=O)Nc1ccc(C#N)cn1
|
C[C@H]1OCC[C@@H]1CCC[S@@+]([O-])CNc1ccc(C#N)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C24=O"
}
|
Can you make molecule C[C@@H](CNC(=O)N(C)CCOc1ccc(F)cc1)c1ccsc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CNC(=O)CC(C)(C)N(C)CCOc1ccc(F)cc1)c1ccsc1
|
C[C@@H](CNC(=O)N(C)CCOc1ccc(F)cc1)c1ccsc1
|
C[C@@H](CNC(=O)CC(C)(C)N(C)CCOc1ccc(F)cc1)c1ccsc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule C[C@@H](CNC(=O)N(C)CCOc1ccc(F)cc1)c1ccsc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CNC(=O)CCC(C)(C)N(C)CCOc1ccc(F)cc1)c1ccsc1
|
C[C@@H](CNC(=O)N(C)CCOc1ccc(F)cc1)c1ccsc1
|
C[C@@H](CNC(=O)CCC(C)(C)N(C)CCOc1ccc(F)cc1)c1ccsc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule C[C@@H](CNC(=O)N(C)CCOc1ccc(F)cc1)c1ccsc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CNC(=O)C[C@@H](Br)N(C)CCOc1ccc(F)cc1)c1ccsc1
|
C[C@@H](CNC(=O)N(C)CCOc1ccc(F)cc1)c1ccsc1
|
C[C@@H](CNC(=O)C[C@@H](Br)N(C)CCOc1ccc(F)cc1)c1ccsc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule C[C@@H](CNC(=O)N(C)CCOc1ccc(F)cc1)c1ccsc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC[C@H](C)c2ccsc2)cc(=O)n1N(C)CCOc1ccc(F)cc1
|
C[C@@H](CNC(=O)N(C)CCOc1ccc(F)cc1)c1ccsc1
|
Cc1cc(NC[C@H](C)c2ccsc2)cc(=O)n1N(C)CCOc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C23=O"
}
|
Can you make molecule C[C@@H](CNC(=O)N(C)CCOc1ccc(F)cc1)c1ccsc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(NC[C@H](C)c2ccsc2)c(=O)ccn1N(C)CCOc1ccc(F)cc1
|
C[C@@H](CNC(=O)N(C)CCOc1ccc(F)cc1)c1ccsc1
|
Cc1c(NC[C@H](C)c2ccsc2)c(=O)ccn1N(C)CCOc1ccc(F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C23=O"
}
|
Can you make molecule Cn1c(N2CCC[C@H](c3nc4ccccc4s3)C2)c(C#N)c(=O)n(C)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(N2CCC[C@H](c3nc4ccc(Br)cc4s3)C2)c(C#N)c(=O)n(C)c1=O
|
Cn1c(N2CCC[C@H](c3nc4ccccc4s3)C2)c(C#N)c(=O)n(C)c1=O
|
Cn1c(N2CCC[C@H](c3nc4ccc(Br)cc4s3)C2)c(C#N)c(=O)n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2ccc(Br)cc2s1",
"old_substring": "c16nc2ccccc2s1"
}
|
Can you make molecule Cn1c(N2CCC[C@H](c3nc4ccccc4s3)C2)c(C#N)c(=O)n(C)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(N2CCC[C@H](c3nc4c(Cl)cccc4s3)C2)c(C#N)c(=O)n(C)c1=O
|
Cn1c(N2CCC[C@H](c3nc4ccccc4s3)C2)c(C#N)c(=O)n(C)c1=O
|
Cn1c(N2CCC[C@H](c3nc4c(Cl)cccc4s3)C2)c(C#N)c(=O)n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2c(Cl)cccc2s1",
"old_substring": "c16nc2ccccc2s1"
}
|
Can you make molecule Cn1c(N2CCC[C@H](c3nc4ccccc4s3)C2)c(C#N)c(=O)n(C)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(N2CCC[C@H](c3nc4cc(Cl)ccc4s3)C2)c(C#N)c(=O)n(C)c1=O
|
Cn1c(N2CCC[C@H](c3nc4ccccc4s3)C2)c(C#N)c(=O)n(C)c1=O
|
Cn1c(N2CCC[C@H](c3nc4cc(Cl)ccc4s3)C2)c(C#N)c(=O)n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2cc(Cl)ccc2s1",
"old_substring": "c16nc2ccccc2s1"
}
|
Can you make molecule Cn1c(N2CCC[C@H](c3nc4ccccc4s3)C2)c(C#N)c(=O)n(C)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(N2CCC[C@H](c3nc4c(Br)cccc4s3)C2)c(C#N)c(=O)n(C)c1=O
|
Cn1c(N2CCC[C@H](c3nc4ccccc4s3)C2)c(C#N)c(=O)n(C)c1=O
|
Cn1c(N2CCC[C@H](c3nc4c(Br)cccc4s3)C2)c(C#N)c(=O)n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2c(Br)cccc2s1",
"old_substring": "c16nc2ccccc2s1"
}
|
Can you make molecule Cn1c(N2CCC[C@H](c3nc4ccccc4s3)C2)c(C#N)c(=O)n(C)c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(N2CCC[C@H](c3nc4ccc(Cl)cc4s3)C2)c(C#N)c(=O)n(C)c1=O
|
Cn1c(N2CCC[C@H](c3nc4ccccc4s3)C2)c(C#N)c(=O)n(C)c1=O
|
Cn1c(N2CCC[C@H](c3nc4ccc(Cl)cc4s3)C2)c(C#N)c(=O)n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2ccc(Cl)cc2s1",
"old_substring": "c16nc2ccccc2s1"
}
|
Can you make molecule CCCOC[C@H]([NH2+]C)C(C)(C)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1ccc(O)c(C[C@H]([NH2+]C)C(C)(C)N2CCOCC2)c2onc1-2
|
CCCOC[C@H]([NH2+]C)C(C)(C)N1CCOCC1
|
CCCc1ccc(O)c(C[C@H]([NH2+]C)C(C)(C)N2CCOCC2)c2onc1-2
| 102
|
{
"fragment_index": 0,
"new_substring": "Oc1ccc2c&noc2c1&",
"old_substring": "O23"
}
|
Can you make molecule CCCOC[C@H]([NH2+]C)C(C)(C)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCN1CCOc2ccc(C[C@H]([NH2+]C)C(C)(C)N3CCOCC3)cc2C1
|
CCCOC[C@H]([NH2+]C)C(C)(C)N1CCOCC1
|
CCCN1CCOc2ccc(C[C@H]([NH2+]C)C(C)(C)N3CCOCC3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1",
"old_substring": "O23"
}
|
Can you make molecule CCCOC[C@H]([NH2+]C)C(C)(C)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cc2ccc-2ncn(C[C@H]([NH2+]C)C(C)(C)N2CCOCC2)c1=O
|
CCCOC[C@H]([NH2+]C)C(C)(C)N1CCOCC1
|
CCCc1cc2ccc-2ncn(C[C@H]([NH2+]C)C(C)(C)N2CCOCC2)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cc&ccc2ncn1&",
"old_substring": "O23"
}
|
Can you make molecule CCCOC[C@H]([NH2+]C)C(C)(C)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1ccc2nc-2ccn(C[C@H]([NH2+]C)C(C)(C)N2CCOCC2)c1=O
|
CCCOC[C@H]([NH2+]C)C(C)(C)N1CCOCC1
|
CCCc1ccc2nc-2ccn(C[C@H]([NH2+]C)C(C)(C)N2CCOCC2)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2ccc&nc2ccn1&",
"old_substring": "O23"
}
|
Can you make molecule CCCOC[C@H]([NH2+]C)C(C)(C)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCc1cnc2nc-2ccn(C[C@H]([NH2+]C)C(C)(C)N2CCOCC2)c1=O
|
CCCOC[C@H]([NH2+]C)C(C)(C)N1CCOCC1
|
CCCc1cnc2nc-2ccn(C[C@H]([NH2+]C)C(C)(C)N2CCOCC2)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cnc&nc2ccn1&",
"old_substring": "O23"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)CCCC(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
|
CCc1nn(C)cc1NC(=O)CCCC(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C3(=O)C4=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)CCC(=O)CN[C@H](C)c1ncc(-c2ccccc2)o1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
|
CCc1nn(C)cc1NC(=O)CCC(=O)CN[C@H](C)c1ncc(-c2ccccc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC(=O)C&",
"old_substring": "C3(=O)C4=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC[S@+]([O-])CCC(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
|
CCc1nn(C)cc1NC[S@+]([O-])CCC(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&=O",
"old_substring": "C3(=O)C4=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)CCCS(=O)(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
|
CCc1nn(C)cc1NC(=O)CCCS(=O)(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCS&(=O)=O",
"old_substring": "C3(=O)C4=O"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)C(C)(F)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
|
CCc1nn(C)cc1NC(=O)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
|
CCc1nn(C)cc1NC(=O)C(C)(F)C(=O)N[C@H](C)c1ncc(-c2ccccc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(F)C&=O",
"old_substring": "C3(=O)C4=O"
}
|
Can you make molecule COc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC
|
COc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC
|
COCc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC
|
COc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC
|
COCSc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(CCNc2nc3ccccc3c3nnc(C)n23)ccc1SC(C)=O
|
COc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC
|
COc1cc(CCNc2nc3ccccc3c3nnc(C)n23)ccc1SC(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(CCNc2nc3ccccc3c3nnc(C)n23)ccc1C(=O)CS
|
COc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC
|
COc1cc(CCNc2nc3ccccc3c3nnc(C)n23)ccc1C(=O)CS
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(CCNc2nc3ccccc3c3nnc(C)n23)ccc1C(=O)CI
|
COc1ccc(CCNc2nc3ccccc3c3nnc(C)n23)cc1OC
|
COc1cc(CCNc2nc3ccccc3c3nnc(C)n23)ccc1C(=O)CI
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO4"
}
|
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