prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule Cc1c(C(=O)N[C@H](C)c2ccc3ccccc3c2)cccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1ccc2ccccc2c1)NC(=O)c1cccc([N+](=O)[O-])c1C
|
Cc1c(C(=O)N[C@H](C)c2ccc3ccccc3c2)cccc1[N+](=O)[O-]
|
CC[C@@H](CCc1ccc2ccccc2c1)NC(=O)c1cccc([N+](=O)[O-])c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@H]57C"
}
|
Can you make molecule Cc1c(C(=O)N[C@H](C)c2ccc3ccccc3c2)cccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)N[C@@H](CBr)CCc2ccc3ccccc3c2)cccc1[N+](=O)[O-]
|
Cc1c(C(=O)N[C@H](C)c2ccc3ccccc3c2)cccc1[N+](=O)[O-]
|
Cc1c(C(=O)N[C@@H](CBr)CCc2ccc3ccccc3c2)cccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CC&",
"old_substring": "[C@H]57C"
}
|
Can you make molecule Cc1c(C(=O)N[C@H](C)c2ccc3ccccc3c2)cccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)N[C@@H](CBr)CCCc2ccc3ccccc3c2)cccc1[N+](=O)[O-]
|
Cc1c(C(=O)N[C@H](C)c2ccc3ccccc3c2)cccc1[N+](=O)[O-]
|
Cc1c(C(=O)N[C@@H](CBr)CCCc2ccc3ccccc3c2)cccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@H]57C"
}
|
Can you make molecule Cc1c(C(=O)N[C@H](C)c2ccc3ccccc3c2)cccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)N[C@H](CCl)CCCc2ccc3ccccc3c2)cccc1[N+](=O)[O-]
|
Cc1c(C(=O)N[C@H](C)c2ccc3ccccc3c2)cccc1[N+](=O)[O-]
|
Cc1c(C(=O)N[C@H](CCl)CCCc2ccc3ccccc3c2)cccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@H]57C"
}
|
Can you make molecule Cc1c(C(=O)N[C@H](C)c2ccc3ccccc3c2)cccc1[N+](=O)[O-] less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)N[C@H]2CCC[C@H](c3ccc4ccccc4c3)C2)cccc1[N+](=O)[O-]
|
Cc1c(C(=O)N[C@H](C)c2ccc3ccccc3c2)cccc1[N+](=O)[O-]
|
Cc1c(C(=O)N[C@H]2CCC[C@H](c3ccc4ccccc4c3)C2)cccc1[N+](=O)[O-]
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@H]57C"
}
|
Can you make molecule N#C[C@H]1CN(C(=O)[C@H]2CNCc3ccccc32)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C[C@@H]1CCCCN1C(=O)[C@H]1CNCc2ccccc21
|
N#C[C@H]1CN(C(=O)[C@H]2CNCc3ccccc32)CCO1
|
N#C[C@@H]1CCCCN1C(=O)[C@H]1CNCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N#C[C@@H]1CCCCN1&",
"old_substring": "N#C[C@H]1CN4CCO1"
}
|
Can you make molecule N#C[C@H]1CN(C(=O)[C@H]2CNCc3ccccc32)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C[C@@]1(C(=O)[C@H]2CNCc3ccccc32)CCSC1
|
N#C[C@H]1CN(C(=O)[C@H]2CNCc3ccccc32)CCO1
|
N#C[C@@]1(C(=O)[C@H]2CNCc3ccccc32)CCSC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#C[C@@]1&CCSC1",
"old_substring": "N#C[C@H]1CN4CCO1"
}
|
Can you make molecule N#C[C@H]1CN(C(=O)[C@H]2CNCc3ccccc32)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C[C@H]1CCO[C@H]1C(=O)[C@H]1CNCc2ccccc21
|
N#C[C@H]1CN(C(=O)[C@H]2CNCc3ccccc32)CCO1
|
N#C[C@H]1CCO[C@H]1C(=O)[C@H]1CNCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N#C[C@H]1CCO[C@H]1&",
"old_substring": "N#C[C@H]1CN4CCO1"
}
|
Can you make molecule N#C[C@H]1CN(C(=O)[C@H]2CNCc3ccccc32)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C[C@]1(C(=O)[C@H]2CNCc3ccccc32)CCCCC1=O
|
N#C[C@H]1CN(C(=O)[C@H]2CNCc3ccccc32)CCO1
|
N#C[C@]1(C(=O)[C@H]2CNCc3ccccc32)CCCCC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N#C[C@]1&CCCCC1=O",
"old_substring": "N#C[C@H]1CN4CCO1"
}
|
Can you make molecule N#C[C@H]1CN(C(=O)[C@H]2CNCc3ccccc32)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C[C@@H](CCCCl)C(=O)[C@H]1CNCc2ccccc21
|
N#C[C@H]1CN(C(=O)[C@H]2CNCc3ccccc32)CCO1
|
N#C[C@@H](CCCCl)C(=O)[C@H]1CNCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N#C[C@H]&CCCCl",
"old_substring": "N#C[C@H]1CN4CCO1"
}
|
Can you make molecule CCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)=NS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
|
CCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
|
CC(C)=NS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&C",
"old_substring": "CC5"
}
|
Can you make molecule CCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
|
CCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
|
C=CSNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC5"
}
|
Can you make molecule CCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(I)=NS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
|
CCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
|
CC(I)=NS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&I",
"old_substring": "CC5"
}
|
Can you make molecule CCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
|
CCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
|
C=CCCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC5"
}
|
Can you make molecule CCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC1CC=CC1)N1CC[C@@H](S(=O)(=O)N=CCCl)C1
|
CCNS(=O)(=O)[C@@H]1CCN(C(=O)NC2CC=CC2)C1
|
O=C(NC1CC=CC1)N1CC[C@@H](S(=O)(=O)N=CCCl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CCl",
"old_substring": "CC5"
}
|
Can you make molecule COc1ccc(CNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CSCNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
|
COc1ccc(CNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
|
COc1ccc(CSCNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N37"
}
|
Can you make molecule COc1ccc(CNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CSC(=N)NC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
|
COc1ccc(CNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
|
COc1ccc(CSC(=N)NC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N37"
}
|
Can you make molecule COc1ccc(CNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CSC(=S)N(C)C(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
|
COc1ccc(CNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
|
COc1ccc(CSC(=S)N(C)C(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N37"
}
|
Can you make molecule COc1ccc(CNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CSC2=NCCN2C(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
|
COc1ccc(CNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
|
COc1ccc(CSC2=NCCN2C(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N37"
}
|
Can you make molecule COc1ccc(CNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CC2CCN(CC(=O)NC[C@H](C)c3ccsc3)CC2)cc1NC(C)=O
|
COc1ccc(CNC(=O)NC[C@H](C)c2ccsc2)cc1NC(C)=O
|
COc1ccc(CC2CCN(CC(=O)NC[C@H](C)c3ccsc3)CC2)cc1NC(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N37"
}
|
Can you make molecule CCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC(n2ncnc2C[C@@H]([NH3+])CSc2ccccc2Cl)C1
|
CCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl
|
CC1CC(n2ncnc2C[C@@H]([NH3+])CSc2ccccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1CC&C1",
"old_substring": "CCC3"
}
|
Can you make molecule CCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl
|
CCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl
|
CC(C)CCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC3"
}
|
Can you make molecule CCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H](CSc1ccccc1Cl)Cc1ncnn1CCCCBr
|
CCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl
|
[NH3+][C@@H](CSc1ccccc1Cl)Cc1ncnn1CCCCBr
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC3"
}
|
Can you make molecule CCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl
|
CCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl
|
C=CCCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC3"
}
|
Can you make molecule CCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
[NH3+][C@@H](CSc1ccccc1Cl)Cc1ncnn1CCCCCl
|
CCCn1ncnc1C[C@@H]([NH3+])CSc1ccccc1Cl
|
[NH3+][C@@H](CSc1ccccc1Cl)Cc1ncnn1CCCCCl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC3"
}
|
Can you make molecule Cc1nc(CCNC(=O)[C@H]2CCC(=O)N(Cc3ccccn3)C2)nc2c1CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=NC=C(CCc2ccccn2)[C@@H]1C(=O)NCCc1nc(C)c2c(n1)CCCC2
|
Cc1nc(CCNC(=O)[C@H]2CCC(=O)N(Cc3ccccn3)C2)nc2c1CCCC2
|
CC1=NC=C(CCc2ccccn2)[C@@H]1C(=O)NCCc1nc(C)c2c(n1)CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C(C&)=CN=C1C",
"old_substring": "[C@H]16CCC(=O)N7C1"
}
|
Can you make molecule Cc1nc(CCNC(=O)[C@H]2CCC(=O)N(Cc3ccccn3)C2)nc2c1CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CCNC(=O)[C@H]2C=C(CCc3ccccn3)N=N2)nc2c1CCCC2
|
Cc1nc(CCNC(=O)[C@H]2CCC(=O)N(Cc3ccccn3)C2)nc2c1CCCC2
|
Cc1nc(CCNC(=O)[C@H]2C=C(CCc3ccccn3)N=N2)nc2c1CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C(C&)N=N1",
"old_substring": "[C@H]16CCC(=O)N7C1"
}
|
Can you make molecule Cc1nc(CCNC(=O)[C@H]2CCC(=O)N(Cc3ccccn3)C2)nc2c1CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CCNC(=O)[C@H]2CCCN(CCc3ccccn3)C2)nc2c1CCCC2
|
Cc1nc(CCNC(=O)[C@H]2CCC(=O)N(Cc3ccccn3)C2)nc2c1CCCC2
|
Cc1nc(CCNC(=O)[C@H]2CCCN(CCc3ccccn3)C2)nc2c1CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCN(C&)C1",
"old_substring": "[C@H]16CCC(=O)N7C1"
}
|
Can you make molecule Cc1nc(CCNC(=O)[C@H]2CCC(=O)N(Cc3ccccn3)C2)nc2c1CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CCNC(=O)[C@H]2CN(Cc3ccccn3)C(C)(C)C2)nc2c1CCCC2
|
Cc1nc(CCNC(=O)[C@H]2CCC(=O)N(Cc3ccccn3)C2)nc2c1CCCC2
|
Cc1nc(CCNC(=O)[C@H]2CN(Cc3ccccn3)C(C)(C)C2)nc2c1CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CN&C(C)(C)C1",
"old_substring": "[C@H]16CCC(=O)N7C1"
}
|
Can you make molecule Cc1nc(CCNC(=O)[C@H]2CCC(=O)N(Cc3ccccn3)C2)nc2c1CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CCNC(=O)[C@H]2CCCCN(Cc3ccccn3)C2)nc2c1CCCC2
|
Cc1nc(CCNC(=O)[C@H]2CCC(=O)N(Cc3ccccn3)C2)nc2c1CCCC2
|
Cc1nc(CCNC(=O)[C@H]2CCCCN(Cc3ccccn3)C2)nc2c1CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCCN&C1",
"old_substring": "[C@H]16CCC(=O)N7C1"
}
|
Can you make molecule COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc([C@@H]2NC(=O)c3cccnc3N2)c1C=O
|
COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O
|
COc1cccc([C@@H]2NC(=O)c3cccnc3N2)c1C=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1C=O",
"old_substring": "c14cc5ccc1O"
}
|
Can you make molecule COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc([C@@H]2NC(=O)c3cccnc3N2)cc1C
|
COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O
|
COc1ccc([C@@H]2NC(=O)c3cccnc3N2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1C",
"old_substring": "c14cc5ccc1O"
}
|
Can you make molecule COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc([C@@H]2NC(=O)c3cccnc3N2)c1F
|
COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O
|
COc1cccc([C@@H]2NC(=O)c3cccnc3N2)c1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1F",
"old_substring": "c14cc5ccc1O"
}
|
Can you make molecule COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc([C@@H]2NC(=O)c3cccnc3N2)cc1I
|
COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O
|
COc1ccc([C@@H]2NC(=O)c3cccnc3N2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c14cc5ccc1O"
}
|
Can you make molecule COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1F
|
COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1O
|
COc1cc([C@@H]2NC(=O)c3cccnc3N2)ccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1F",
"old_substring": "c14cc5ccc1O"
}
|
Can you make molecule CC1CC[NH+](Cc2ccccc2CNC(=O)N(C)[C@H](C)c2cccc(O)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](Cc2ccccc2CNC(=O)CC(C)(C)N(C)[C@H](C)c2cccc(O)c2)CC1
|
CC1CC[NH+](Cc2ccccc2CNC(=O)N(C)[C@H](C)c2cccc(O)c2)CC1
|
CC1CC[NH+](Cc2ccccc2CNC(=O)CC(C)(C)N(C)[C@H](C)c2cccc(O)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CC1CC[NH+](Cc2ccccc2CNC(=O)N(C)[C@H](C)c2cccc(O)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](Cc2ccccc2CNC(=O)CCC(C)(C)N(C)[C@H](C)c2cccc(O)c2)CC1
|
CC1CC[NH+](Cc2ccccc2CNC(=O)N(C)[C@H](C)c2cccc(O)c2)CC1
|
CC1CC[NH+](Cc2ccccc2CNC(=O)CCC(C)(C)N(C)[C@H](C)c2cccc(O)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CC1CC[NH+](Cc2ccccc2CNC(=O)N(C)[C@H](C)c2cccc(O)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](Cc2ccccc2CNC(=O)C[C@@H](Br)N(C)[C@H](C)c2cccc(O)c2)CC1
|
CC1CC[NH+](Cc2ccccc2CNC(=O)N(C)[C@H](C)c2cccc(O)c2)CC1
|
CC1CC[NH+](Cc2ccccc2CNC(=O)C[C@@H](Br)N(C)[C@H](C)c2cccc(O)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule CC1CC[NH+](Cc2ccccc2CNC(=O)N(C)[C@H](C)c2cccc(O)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NCc2ccccc2C[NH+]2CCC(C)CC2)cc(=O)n1N(C)[C@H](C)c1cccc(O)c1
|
CC1CC[NH+](Cc2ccccc2CNC(=O)N(C)[C@H](C)c2cccc(O)c2)CC1
|
Cc1cc(NCc2ccccc2C[NH+]2CCC(C)CC2)cc(=O)n1N(C)[C@H](C)c1cccc(O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C34=O"
}
|
Can you make molecule CC1CC[NH+](Cc2ccccc2CNC(=O)N(C)[C@H](C)c2cccc(O)c2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(NCc2ccccc2C[NH+]2CCC(C)CC2)c(=O)ccn1N(C)[C@H](C)c1cccc(O)c1
|
CC1CC[NH+](Cc2ccccc2CNC(=O)N(C)[C@H](C)c2cccc(O)c2)CC1
|
Cc1c(NCc2ccccc2C[NH+]2CCC(C)CC2)c(=O)ccn1N(C)[C@H](C)c1cccc(O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C34=O"
}
|
Can you make molecule COc1ccc(OCCNC(=O)N[C@H](C)c2cn(C)nc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(OCCNC(=O)CC(C)(C)N[C@H](C)c2cn(C)nc2C)cc1
|
COc1ccc(OCCNC(=O)N[C@H](C)c2cn(C)nc2C)cc1
|
COc1ccc(OCCNC(=O)CC(C)(C)N[C@H](C)c2cn(C)nc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule COc1ccc(OCCNC(=O)N[C@H](C)c2cn(C)nc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(OCCNC(=O)CCC(C)(C)N[C@H](C)c2cn(C)nc2C)cc1
|
COc1ccc(OCCNC(=O)N[C@H](C)c2cn(C)nc2C)cc1
|
COc1ccc(OCCNC(=O)CCC(C)(C)N[C@H](C)c2cn(C)nc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule COc1ccc(OCCNC(=O)N[C@H](C)c2cn(C)nc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(OCCNc2c(C)n(C)n(N[C@H](C)c3cn(C)nc3C)c2=O)cc1
|
COc1ccc(OCCNC(=O)N[C@H](C)c2cn(C)nc2C)cc1
|
COc1ccc(OCCNc2c(C)n(C)n(N[C@H](C)c3cn(C)nc3C)c2=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)n&n1C",
"old_substring": "C34=O"
}
|
Can you make molecule COc1ccc(OCCNC(=O)N[C@H](C)c2cn(C)nc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(OCCNc2nn(N[C@H](C)c3cn(C)nc3C)c(C)cc2=O)cc1
|
COc1ccc(OCCNC(=O)N[C@H](C)c2cn(C)nc2C)cc1
|
COc1ccc(OCCNc2nn(N[C@H](C)c3cn(C)nc3C)c(C)cc2=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(=O)c&nn1&",
"old_substring": "C34=O"
}
|
Can you make molecule COc1ccc(OCCNC(=O)N[C@H](C)c2cn(C)nc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(OCCNC(=O)C[C@@H](Br)N[C@H](C)c2cn(C)nc2C)cc1
|
COc1ccc(OCCNC(=O)N[C@H](C)c2cn(C)nc2C)cc1
|
COc1ccc(OCCNC(=O)C[C@@H](Br)N[C@H](C)c2cn(C)nc2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccn(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)c1
|
COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)no1
|
COCc1ccn(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccn&c1",
"old_substring": "c17cc6no1"
}
|
Can you make molecule COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)o1
|
COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)no1
|
COCc1ccc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&o1",
"old_substring": "c17cc6no1"
}
|
Can you make molecule COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)oc1C
|
COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)no1
|
COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&oc1C",
"old_substring": "c17cc6no1"
}
|
Can you make molecule COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc2nc(C(=O)N[C@@H]3CCCC[C@H]3C(C)C)oc2c1
|
COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)no1
|
COCc1ccc2nc(C(=O)N[C@@H]3CCCC[C@H]3C(C)C)oc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc2nc&oc2c1",
"old_substring": "c17cc6no1"
}
|
Can you make molecule COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)no1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc2noc(C(=O)N[C@@H]3CCCC[C@H]3C(C)C)c2c1
|
COCc1cc(C(=O)N[C@@H]2CCCC[C@H]2C(C)C)no1
|
COCc1ccc2noc(C(=O)N[C@@H]3CCCC[C@H]3C(C)C)c2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc2noc&c2c1",
"old_substring": "c17cc6no1"
}
|
Can you make molecule CC[C@H](C)Nc1ncnc(Nc2cccc3ccccc23)c1N less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)c1nsc(-c2ncnc(Nc3cccc4ccccc34)c2N)c1N
|
CC[C@H](C)Nc1ncnc(Nc2cccc3ccccc23)c1N
|
CC[C@H](C)c1nsc(-c2ncnc(Nc3cccc4ccccc34)c2N)c1N
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&nsc1&",
"old_substring": "N45"
}
|
Can you make molecule CC[C@H](C)Nc1ncnc(Nc2cccc3ccccc23)c1N less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)N(C)C(=S)Sc1ncnc(Nc2cccc3ccccc23)c1N
|
CC[C@H](C)Nc1ncnc(Nc2cccc3ccccc23)c1N
|
CC[C@H](C)N(C)C(=S)Sc1ncnc(Nc2cccc3ccccc23)c1N
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N45"
}
|
Can you make molecule CC[C@H](C)Nc1ncnc(Nc2cccc3ccccc23)c1N less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)c1cc(-c2ncnc(Nc3cccc4ccccc34)c2N)c(N)o1
|
CC[C@H](C)Nc1ncnc(Nc2cccc3ccccc23)c1N
|
CC[C@H](C)c1cc(-c2ncnc(Nc3cccc4ccccc34)c2N)c(N)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1oc&cc1&",
"old_substring": "N45"
}
|
Can you make molecule CC[C@H](C)Nc1ncnc(Nc2cccc3ccccc23)c1N less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)N1CCN=C1Sc1ncnc(Nc2cccc3ccccc23)c1N
|
CC[C@H](C)Nc1ncnc(Nc2cccc3ccccc23)c1N
|
CC[C@H](C)N1CCN=C1Sc1ncnc(Nc2cccc3ccccc23)c1N
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N45"
}
|
Can you make molecule CC[C@H](C)Nc1ncnc(Nc2cccc3ccccc23)c1N less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)CN1CCC(c2ncnc(Nc3cccc4ccccc34)c2N)CC1
|
CC[C@H](C)Nc1ncnc(Nc2cccc3ccccc23)c1N
|
CC[C@H](C)CN1CCC(c2ncnc(Nc3cccc4ccccc34)c2N)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N45"
}
|
Can you make molecule C[C@H](NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(C)(C)c1ccccc1)NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1
|
C[C@H](NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)c1ccccc1
|
C[C@H](CC(C)(C)c1ccccc1)NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@H]57"
}
|
Can you make molecule C[C@H](NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CCNC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)CC(=O)c1ccccc1
|
C[C@H](NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)c1ccccc1
|
C[C@H](CCNC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)CC(=O)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "C[C@H]57"
}
|
Can you make molecule C[C@H](NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Cc1ccccc1)[C@H](C)NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1
|
C[C@H](NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)c1ccccc1
|
C[C@H](Cc1ccccc1)[C@H](C)NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&[C@H](C)C&",
"old_substring": "C[C@H]57"
}
|
Can you make molecule C[C@H](NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCNC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)CC(=O)c1ccccc1
|
C[C@H](NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)c1ccccc1
|
C[C@@H](CCNC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)CC(=O)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@H]57"
}
|
Can you make molecule C[C@H](NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CCc1ccccc1)NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1
|
C[C@H](NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1)c1ccccc1
|
CCC[C@@H](CCc1ccccc1)NC(=O)CSc1nnc2c3cc(Br)ccc3n(C)c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&",
"old_substring": "C[C@H]57"
}
|
Can you make molecule CC(C)[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CC[C@H](CCCBr)[C@H](OC(=O)C=O)C1
|
CC(C)[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O
|
C[C@@H]1CC[C@H](CCCBr)[C@H](OC(=O)C=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CC[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O
|
CC(C)[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O
|
CC(C)CC[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CC[C@H](CCCCBr)[C@H](OC(=O)C=O)C1
|
CC(C)[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O
|
C[C@@H]1CC[C@H](CCCCBr)[C@H](OC(=O)C=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCC[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O
|
CC(C)[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O
|
C=CCCC[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CC[C@H](CCCCCl)[C@H](OC(=O)C=O)C1
|
CC(C)[C@H]1CC[C@@H](C)C[C@H]1OC(=O)C=O
|
C[C@@H]1CC[C@H](CCCCCl)[C@H](OC(=O)C=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CC4C"
}
|
Can you make molecule CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[NH+](C(C)C)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1c(NC(=O)C(CC)CC)sc2c1CC[NH+](C(C)C)C2
|
CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[NH+](C(C)C)C2
|
CCOC(=O)c1c(NC(=O)C(CC)CC)sc2c1CC[NH+](C(C)C)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(CC)CC",
"old_substring": "C4(=O)C(C)C"
}
|
Can you make molecule CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[NH+](C(C)C)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1c(NC(=O)C(C)(C)Br)sc2c1CC[NH+](C(C)C)C2
|
CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[NH+](C(C)C)C2
|
CCOC(=O)c1c(NC(=O)C(C)(C)Br)sc2c1CC[NH+](C(C)C)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)Br",
"old_substring": "C4(=O)C(C)C"
}
|
Can you make molecule CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[NH+](C(C)C)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1c(NC(=O)C(C)(C)CCl)sc2c1CC[NH+](C(C)C)C2
|
CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[NH+](C(C)C)C2
|
CCOC(=O)c1c(NC(=O)C(C)(C)CCl)sc2c1CC[NH+](C(C)C)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)CCl",
"old_substring": "C4(=O)C(C)C"
}
|
Can you make molecule CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[NH+](C(C)C)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1c(NC(=O)C(Cl)(Cl)Cl)sc2c1CC[NH+](C(C)C)C2
|
CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[NH+](C(C)C)C2
|
CCOC(=O)c1c(NC(=O)C(Cl)(Cl)Cl)sc2c1CC[NH+](C(C)C)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(Cl)(Cl)Cl",
"old_substring": "C4(=O)C(C)C"
}
|
Can you make molecule CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[NH+](C(C)C)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H](C)C(=O)Nc1sc2c(c1C(=O)OCC)CC[NH+](C(C)C)C2
|
CCOC(=O)c1c(NC(=O)C(C)C)sc2c1CC[NH+](C(C)C)C2
|
CCC[C@H](C)C(=O)Nc1sc2c(c1C(=O)OCC)CC[NH+](C(C)C)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)[C@@H](C)CCC",
"old_substring": "C4(=O)C(C)C"
}
|
Can you make molecule O=C(N[C@H](c1ccccc1)C1CCCC1)[C@H]1Cc2ccccc2S1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/S[C@H]1Cc2ccccc2S1)N[C@H](c1ccccc1)C1CCCC1
|
O=C(N[C@H](c1ccccc1)C1CCCC1)[C@H]1Cc2ccccc2S1
|
O=C(/C=C/S[C@H]1Cc2ccccc2S1)N[C@H](c1ccccc1)C1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(N[C@H](c1ccccc1)C1CCCC1)[C@H]1Cc2ccccc2S1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(N[C@H](c2ccccc2)C2CCCC2)nc1[C@H]1Cc2ccccc2S1
|
O=C(N[C@H](c1ccccc1)C1CCCC1)[C@H]1Cc2ccccc2S1
|
O=Cc1sc(N[C@H](c2ccccc2)C2CCCC2)nc1[C@H]1Cc2ccccc2S1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(N[C@H](c1ccccc1)C1CCCC1)[C@H]1Cc2ccccc2S1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(N[C@H](c2ccccc2)C2CCCC2)sc1[C@H]1Cc2ccccc2S1
|
O=C(N[C@H](c1ccccc1)C1CCCC1)[C@H]1Cc2ccccc2S1
|
O=Cc1nc(N[C@H](c2ccccc2)C2CCCC2)sc1[C@H]1Cc2ccccc2S1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(N[C@H](c1ccccc1)C1CCCC1)[C@H]1Cc2ccccc2S1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(N/N=C/C[C@H]1Cc2ccccc2S1)N[C@H](c1ccccc1)C1CCCC1
|
O=C(N[C@H](c1ccccc1)C1CCCC1)[C@H]1Cc2ccccc2S1
|
O=C(N/N=C/C[C@H]1Cc2ccccc2S1)N[C@H](c1ccccc1)C1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&N/N=C/C&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(N[C@H](c1ccccc1)C1CCCC1)[C@H]1Cc2ccccc2S1 less soluble in water? The output molecule should be similar to the input molecule.
|
c1ccc([C@@H](NON=C2CCN([C@H]3Cc4ccccc4S3)CC2)C2CCCC2)cc1
|
O=C(N[C@H](c1ccccc1)C1CCCC1)[C@H]1Cc2ccccc2S1
|
c1ccc([C@@H](NON=C2CCN([C@H]3Cc4ccccc4S3)CC2)C2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "O=C35"
}
|
Can you make molecule Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(F)c3)o2)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3cc4cc(F)ccc4s3)o2)nc1
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(F)c3)o2)nc1
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3cc4cc(F)ccc4s3)o2)nc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cc(F)ccc2s1",
"old_substring": "c15cccc(F)c1"
}
|
Can you make molecule Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(F)c3)o2)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(Br)c3C)o2)nc1
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(F)c3)o2)nc1
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(Br)c3C)o2)nc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(Br)c1C",
"old_substring": "c15cccc(F)c1"
}
|
Can you make molecule Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(F)c3)o2)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3oc4ccc(F)cc4c3C)o2)nc1
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(F)c3)o2)nc1
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3oc4ccc(F)cc4c3C)o2)nc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&oc2ccc(F)cc2c1C",
"old_substring": "c15cccc(F)c1"
}
|
Can you make molecule Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(F)c3)o2)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3cc(F)ccc3Br)o2)nc1
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(F)c3)o2)nc1
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3cc(F)ccc3Br)o2)nc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1Br",
"old_substring": "c15cccc(F)c1"
}
|
Can you make molecule Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(F)c3)o2)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3ccc(F)cc3Cl)o2)nc1
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3cccc(F)c3)o2)nc1
|
Cc1ccc([S@+]([O-])Cc2ncc(-c3ccc(F)cc3Cl)o2)nc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c15cccc(F)c1"
}
|
Can you make molecule N#Cc1ccc(F)c(CNC(=O)c2cccc(OC(F)F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1ccc(F)c(CNSC(=O)Cc2cccc(OC(F)F)c2)c1
|
N#Cc1ccc(F)c(CNC(=O)c2cccc(OC(F)F)c2)c1
|
N#Cc1ccc(F)c(CNSC(=O)Cc2cccc(OC(F)F)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule N#Cc1ccc(F)c(CNC(=O)c2cccc(OC(F)F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1ccc(F)c(CNC(=O)CCCC(=O)c2cccc(OC(F)F)c2)c1
|
N#Cc1ccc(F)c(CNC(=O)c2cccc(OC(F)F)c2)c1
|
N#Cc1ccc(F)c(CNC(=O)CCCC(=O)c2cccc(OC(F)F)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
}
|
Can you make molecule N#Cc1ccc(F)c(CNC(=O)c2cccc(OC(F)F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)NCc1cc(C#N)ccc1F)c1cccc(OC(F)F)c1
|
N#Cc1ccc(F)c(CNC(=O)c2cccc(OC(F)F)c2)c1
|
CC(C)(CC(=O)NCc1cc(C#N)ccc1F)c1cccc(OC(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule N#Cc1ccc(F)c(CNC(=O)c2cccc(OC(F)F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)NCc1cc(C#N)ccc1F)c1cccc(OC(F)F)c1
|
N#Cc1ccc(F)c(CNC(=O)c2cccc(OC(F)F)c2)c1
|
CC(C)(CCC(=O)NCc1cc(C#N)ccc1F)c1cccc(OC(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule N#Cc1ccc(F)c(CNC(=O)c2cccc(OC(F)F)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SNCc1cc(C#N)ccc1F)c1cccc(OC(F)F)c1
|
N#Cc1ccc(F)c(CNC(=O)c2cccc(OC(F)F)c2)c1
|
C[C@H](C(=O)SNCc1cc(C#N)ccc1F)c1cccc(OC(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C36=O"
}
|
Can you make molecule COCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1
|
COCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1
|
COCCCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C3C5"
}
|
Can you make molecule COCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1
|
COCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1
|
COCCCCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C3C5"
}
|
Can you make molecule COCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@H]1C[C@H]1C(=O)N(C1CCCC1)C1CC(OC)C1
|
COCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1
|
COc1ccccc1[C@H]1C[C@H]1C(=O)N(C1CCCC1)C1CC(OC)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C3C5"
}
|
Can you make molecule COCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@H]1C[C@H]1C(=O)N(CC[C@H](C)OC)C1CCCC1
|
COCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1
|
COc1ccccc1[C@H]1C[C@H]1C(=O)N(CC[C@H](C)OC)C1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C3C5"
}
|
Can you make molecule COCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@H]1C[C@H]1C(=O)N(C1CCCC1)C1CCC(OC)CC1
|
COCCN(C(=O)[C@@H]1C[C@@H]1c1ccccc1OC)C1CCCC1
|
COc1ccccc1[C@H]1C[C@H]1C(=O)N(C1CCCC1)C1CCC(OC)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C3C5"
}
|
Can you make molecule COC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COSC(=O)Cc1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
|
COC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
|
COSC(=O)Cc1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C45=O"
}
|
Can you make molecule COC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CCCC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
|
COC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
|
COC(=O)CCCC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C45=O"
}
|
Can you make molecule COC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CC(C)(C)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
|
COC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
|
COC(=O)CC(C)(C)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule COC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CCC(C)(C)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
|
COC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
|
COC(=O)CCC(C)(C)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule COC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COSC(=O)[C@@H](C)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
|
COC(=O)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
|
COSC(=O)[C@@H](C)c1ccc(/C=N/Nc2nnc3c(n2)[nH]c2ccc(C)cc23)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C45=O"
}
|
Can you make molecule CCc1nc(CN2CCN(C(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nc(CN2CCN(CCC(CO)=C3C[C@H](C)O[C@@H](C)C3)CC2)cs1
|
CCc1nc(CN2CCN(C(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1
|
CCc1nc(CN2CCN(CCC(CO)=C3C[C@H](C)O[C@@H](C)C3)CC2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C46=O"
}
|
Can you make molecule CCc1nc(CN2CCN(C(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nc(CN2CCN(SC(=O)CC3C[C@H](C)O[C@@H](C)C3)CC2)cs1
|
CCc1nc(CN2CCN(C(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1
|
CCc1nc(CN2CCN(SC(=O)CC3C[C@H](C)O[C@@H](C)C3)CC2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule CCc1nc(CN2CCN(C(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nc(CN2CCN(CC(=C=O)CC3C[C@H](C)O[C@@H](C)C3)CC2)cs1
|
CCc1nc(CN2CCN(C(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1
|
CCc1nc(CN2CCN(CC(=C=O)CC3C[C@H](C)O[C@@H](C)C3)CC2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule CCc1nc(CN2CCN(C(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nc(CN2CCN(C(=O)CCCC(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1
|
CCc1nc(CN2CCN(C(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1
|
CCc1nc(CN2CCN(C(=O)CCCC(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule CCc1nc(CN2CCN(C(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nc(CN2CCN(C(=O)CC(C)(C)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1
|
CCc1nc(CN2CCN(C(=O)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1
|
CCc1nc(CN2CCN(C(=O)CC(C)(C)C3C[C@H](C)O[C@@H](C)C3)CC2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.