prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSn1c(C)cc(CNCC[NH+]2CCCCC2)c1C
|
CCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C
|
C=CSn1c(C)cc(CNCC[NH+]2CCCCC2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC6"
}
|
Can you make molecule CCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(CNCC[NH+]2CCCCC2)c(C)n1C(C)C
|
CCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C
|
Cc1cc(CNCC[NH+]2CCCCC2)c(C)n1C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC6"
}
|
Can you make molecule CCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C
|
CCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C
|
C=CCCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC6"
}
|
Can you make molecule CCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(CNCC[NH+]2CCCCC2)c(C)n1CCCCl
|
CCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C
|
Cc1cc(CNCC[NH+]2CCCCC2)c(C)n1CCCCl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC6"
}
|
Can you make molecule CCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(CNCC[NH+]2CCCCC2)c(C)n1CCCCS
|
CCn1c(C)cc(CNCC[NH+]2CCCCC2)c1C
|
Cc1cc(CNCC[NH+]2CCCCC2)c(C)n1CCCCS
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC6"
}
|
Can you make molecule CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)nc2ccc(Br)cc2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2Cl)nc2ccc(Br)cc2c1=O
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)nc2ccc(Br)cc2c1=O
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2Cl)nc2ccc(Br)cc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)nc2ccc(Br)cc2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccc(I)cc2)nc2ccc(Br)cc2c1=O
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)nc2ccc(Br)cc2c1=O
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccc(I)cc2)nc2ccc(Br)cc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)nc2ccc(Br)cc2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccc(C)c(I)c2)nc2ccc(Br)cc2c1=O
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)nc2ccc(Br)cc2c1=O
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccc(C)c(I)c2)nc2ccc(Br)cc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)nc2ccc(Br)cc2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2cccc(Br)c2)nc2ccc(Br)cc2c1=O
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)nc2ccc(Br)cc2c1=O
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2cccc(Br)c2)nc2ccc(Br)cc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)nc2ccc(Br)cc2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2cccc(C)c2C)nc2ccc(Br)cc2c1=O
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)nc2ccc(Br)cc2c1=O
|
CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2cccc(C)c2C)nc2ccc(Br)cc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2Br)c1
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2)c1
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc2ccccc2c1Br",
"old_substring": "c19ccc2ccccc2c1"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3cc(Br)ccc3c2)c1
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2)c1
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3cc(Br)ccc3c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1ccc2cc&ccc2c1",
"old_substring": "c19ccc2ccccc2c1"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2cc3sc4ccccc4c3s2)c1
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2)c1
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2cc3sc4ccccc4c3s2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2sc3ccccc3c2s1",
"old_substring": "c19ccc2ccccc2c1"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc(Cl)c3ccccc23)c1
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2)c1
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc(Cl)c3ccccc23)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c2ccccc12",
"old_substring": "c19ccc2ccccc2c1"
}
|
Can you make molecule CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2sc3ccccc3c2Cl)c1
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2ccc3ccccc3c2)c1
|
CCN(CC)S(=O)(=O)c1ccc(C)c(NC(=O)c2sc3ccccc3c2Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sc2ccccc2c1Cl",
"old_substring": "c19ccc2ccccc2c1"
}
|
Can you make molecule CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2I)cc1
|
CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2)cc1
|
CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2I)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c15ccc8cc1"
}
|
Can you make molecule CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)Nc1ccc(C(=O)COc2cc(C(N)=O)ccc2Br)cc1
|
CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2)cc1
|
CCC(=O)Nc1ccc(C(=O)COc2cc(C(N)=O)ccc2Br)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c15ccc8cc1"
}
|
Can you make molecule CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2Cl)cc1
|
CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2)cc1
|
CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c15ccc8cc1"
}
|
Can you make molecule CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)Nc1ccc(C(=O)COc2cccc(C(N)=O)c2Br)cc1
|
CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2)cc1
|
CCC(=O)Nc1ccc(C(=O)COc2cccc(C(N)=O)c2Br)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c15ccc8cc1"
}
|
Can you make molecule CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)Nc1ccc(C(=O)COc2cccc(C(N)=O)c2Cl)cc1
|
CCC(=O)Nc1ccc(C(=O)COc2ccc(C(N)=O)cc2)cc1
|
CCC(=O)Nc1ccc(C(=O)COc2cccc(C(N)=O)c2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c15ccc8cc1"
}
|
Can you make molecule Cc1ccc2cc(C#N)c(SCC(=O)Nc3c(C)cccc3C)nc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2cc(C#N)c(SCSCC(=O)Nc3c(C)cccc3C)nc2c1
|
Cc1ccc2cc(C#N)c(SCC(=O)Nc3c(C)cccc3C)nc2c1
|
Cc1ccc2cc(C#N)c(SCSCC(=O)Nc3c(C)cccc3C)nc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&CS&",
"old_substring": "S57"
}
|
Can you make molecule Cc1ccc2cc(C#N)c(SCC(=O)Nc3c(C)cccc3C)nc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2cc(C#N)c(-c3ccc4c(c3)N(CC(=O)Nc3c(C)cccc3C)CCS4)nc2c1
|
Cc1ccc2cc(C#N)c(SCC(=O)Nc3c(C)cccc3C)nc2c1
|
Cc1ccc2cc(C#N)c(-c3ccc4c(c3)N(CC(=O)Nc3c(C)cccc3C)CCS4)nc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "S57"
}
|
Can you make molecule Cc1ccc2cc(C#N)c(SCC(=O)Nc3c(C)cccc3C)nc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2cc(C#N)c(C(Cl)(Cl)[S@+]([O-])CCC(=O)Nc3c(C)cccc3C)nc2c1
|
Cc1ccc2cc(C#N)c(SCC(=O)Nc3c(C)cccc3C)nc2c1
|
Cc1ccc2cc(C#N)c(C(Cl)(Cl)[S@+]([O-])CCC(=O)Nc3c(C)cccc3C)nc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=[S@](C&)C&(Cl)Cl",
"old_substring": "S57"
}
|
Can you make molecule Cc1ccc2cc(C#N)c(SCC(=O)Nc3c(C)cccc3C)nc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2cc(C#N)c(N/C(C#N)=C(\Cl)SCC(=O)Nc3c(C)cccc3C)nc2c1
|
Cc1ccc2cc(C#N)c(SCC(=O)Nc3c(C)cccc3C)nc2c1
|
Cc1ccc2cc(C#N)c(N/C(C#N)=C(\Cl)SCC(=O)Nc3c(C)cccc3C)nc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&/C(Cl)=C(\\C#N)N&",
"old_substring": "S57"
}
|
Can you make molecule Cc1ccc2cc(C#N)c(SCC(=O)Nc3c(C)cccc3C)nc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2cc(C#N)c(-n3c(=S)n(CC(=O)Nc4c(C)cccc4C)c4ccccc43)nc2c1
|
Cc1ccc2cc(C#N)c(SCC(=O)Nc3c(C)cccc3C)nc2c1
|
Cc1ccc2cc(C#N)c(-n3c(=S)n(CC(=O)Nc4c(C)cccc4C)c4ccccc43)nc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&c(=S)n&c2ccccc21",
"old_substring": "S57"
}
|
Can you make molecule CCCn1ncc(C[NH2+]C)c1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1ncc(C2=CC=C([NH2+]C)N3CCC3=C2)c1C(F)(F)F
|
CCCn1ncc(C[NH2+]C)c1C(F)(F)F
|
CCCn1ncc(C2=CC=C([NH2+]C)N3CCC3=C2)c1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2cc&ccc21",
"old_substring": "C25"
}
|
Can you make molecule CCCn1ncc(C[NH2+]C)c1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1ncc(-c2ncnc3sc-3c(C)c2[NH2+]C)c1C(F)(F)F
|
CCCn1ncc(C[NH2+]C)c1C(F)(F)F
|
CCCn1ncc(-c2ncnc3sc-3c(C)c2[NH2+]C)c1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&sc2ncnc&c12",
"old_substring": "C25"
}
|
Can you make molecule CCCn1ncc(C[NH2+]C)c1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1ncc(C2=CC=C3SCCN3C([NH2+]C)=C2)c1C(F)(F)F
|
CCCn1ncc(C[NH2+]C)c1C(F)(F)F
|
CCCn1ncc(C2=CC=C3SCCN3C([NH2+]C)=C2)c1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "C25"
}
|
Can you make molecule CCCn1ncc(C[NH2+]C)c1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1ncc(C2=C3CCN3CC([NH2+]C)=CC=C2)c1C(F)(F)F
|
CCCn1ncc(C[NH2+]C)c1C(F)(F)F
|
CCCn1ncc(C2=C3CCN3CC([NH2+]C)=CC=C2)c1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2c&cccc2C1",
"old_substring": "C25"
}
|
Can you make molecule CCCn1ncc(C[NH2+]C)c1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1ncc(-c2ccc([NH2+]C)c(C)c3sc-3n2)c1C(F)(F)F
|
CCCn1ncc(C[NH2+]C)c1C(F)(F)F
|
CCCn1ncc(-c2ccc([NH2+]C)c(C)c3sc-3n2)c1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&sc2nc&ccc12",
"old_substring": "C25"
}
|
Can you make molecule C[NH+](C)CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)CCCCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N
|
C[NH+](C)CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N
|
C[NH+](C)CCCCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C2C3"
}
|
Can you make molecule C[NH+](C)CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)CCCCCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N
|
C[NH+](C)CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N
|
C[NH+](C)CCCCCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C2C3"
}
|
Can you make molecule C[NH+](C)CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)C1CC(S[C@@H]2C[C@H](C(C)(C)C)CC[C@@H]2C#N)C1
|
C[NH+](C)CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N
|
C[NH+](C)C1CC(S[C@@H]2C[C@H](C(C)(C)C)CC[C@@H]2C#N)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C2C3"
}
|
Can you make molecule C[NH+](C)CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N)[NH+](C)C
|
C[NH+](C)CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N
|
C[C@@H](CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N)[NH+](C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C2C3"
}
|
Can you make molecule C[NH+](C)CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)C1CCC(S[C@@H]2C[C@H](C(C)(C)C)CC[C@@H]2C#N)CC1
|
C[NH+](C)CCS[C@@H]1C[C@H](C(C)(C)C)CC[C@@H]1C#N
|
C[NH+](C)C1CCC(S[C@@H]2C[C@H](C(C)(C)C)CC[C@@H]2C#N)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C2C3"
}
|
Can you make molecule Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3)[NH+](C)C)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3Cl)[NH+](C)C)cc12
|
Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3)[NH+](C)C)cc12
|
Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3Cl)[NH+](C)C)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c19ccccc1"
}
|
Can you make molecule Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3)[NH+](C)C)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccc(I)cc3)[NH+](C)C)cc12
|
Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3)[NH+](C)C)cc12
|
Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccc(I)cc3)[NH+](C)C)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c19ccccc1"
}
|
Can you make molecule Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3)[NH+](C)C)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H](CNC(=O)Nc2cnc3c(c2)c(C)nn3C)[NH+](C)C)cc1I
|
Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3)[NH+](C)C)cc12
|
Cc1ccc([C@@H](CNC(=O)Nc2cnc3c(c2)c(C)nn3C)[NH+](C)C)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c19ccccc1"
}
|
Can you make molecule Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3)[NH+](C)C)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3cccc(Br)c3)[NH+](C)C)cc12
|
Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3)[NH+](C)C)cc12
|
Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3cccc(Br)c3)[NH+](C)C)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c19ccccc1"
}
|
Can you make molecule Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3)[NH+](C)C)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@@H](CNC(=O)Nc2cnc3c(c2)c(C)nn3C)[NH+](C)C)c1C
|
Cc1nn(C)c2ncc(NC(=O)NC[C@H](c3ccccc3)[NH+](C)C)cc12
|
Cc1cccc([C@@H](CNC(=O)Nc2cnc3c(c2)c(C)nn3C)[NH+](C)C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c19ccccc1"
}
|
Can you make molecule CC(C)(C)C[NH+]1CCN(Cc2cccc3cccnc23)C[C@@H]1CCO less soluble in water? The output molecule should be similar to the input molecule.
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C=CO[C@H]1CN(Cc2cccc3cccnc23)CC[NH+]1CC(C)(C)C
|
CC(C)(C)C[NH+]1CCN(Cc2cccc3cccnc23)C[C@@H]1CCO
|
C=CO[C@H]1CN(Cc2cccc3cccnc23)CC[NH+]1CC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CO&",
"old_substring": "C6CO"
}
|
Can you make molecule CC(C)(C)C[NH+]1CCN(Cc2cccc3cccnc23)C[C@@H]1CCO less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)[C@H]1CN(Cc2cccc3cccnc23)CC[NH+]1CC(C)(C)C
|
CC(C)(C)C[NH+]1CCN(Cc2cccc3cccnc23)C[C@@H]1CCO
|
CCC(=O)[C@H]1CN(Cc2cccc3cccnc23)CC[NH+]1CC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&=O",
"old_substring": "C6CO"
}
|
Can you make molecule CC(C)(C)C[NH+]1CCN(Cc2cccc3cccnc23)C[C@@H]1CCO less soluble in water? The output molecule should be similar to the input molecule.
|
C=C=CO[C@H]1CN(Cc2cccc3cccnc23)CC[NH+]1CC(C)(C)C
|
CC(C)(C)C[NH+]1CCN(Cc2cccc3cccnc23)C[C@@H]1CCO
|
C=C=CO[C@H]1CN(Cc2cccc3cccnc23)CC[NH+]1CC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C=CO&",
"old_substring": "C6CO"
}
|
Can you make molecule CC(C)(C)C[NH+]1CCN(Cc2cccc3cccnc23)C[C@@H]1CCO less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H]1CN(Cc2cccc3cccnc23)CC[NH+]1CC(C)(C)C
|
CC(C)(C)C[NH+]1CCN(Cc2cccc3cccnc23)C[C@@H]1CCO
|
CC[C@H]1CN(Cc2cccc3cccnc23)CC[NH+]1CC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC&",
"old_substring": "C6CO"
}
|
Can you make molecule CC(C)(C)C[NH+]1CCN(Cc2cccc3cccnc23)C[C@@H]1CCO less soluble in water? The output molecule should be similar to the input molecule.
|
C/C=N/O[C@H]1CN(Cc2cccc3cccnc23)CC[NH+]1CC(C)(C)C
|
CC(C)(C)C[NH+]1CCN(Cc2cccc3cccnc23)C[C@@H]1CCO
|
C/C=N/O[C@H]1CN(Cc2cccc3cccnc23)CC[NH+]1CC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C=N/O&",
"old_substring": "C6CO"
}
|
Can you make molecule COc1cccc(-c2nnn(CCOc3cccc([N+](=O)[O-])c3)n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-c2nnn(CCCCOc3cccc([N+](=O)[O-])c3)n2)c1
|
COc1cccc(-c2nnn(CCOc3cccc([N+](=O)[O-])c3)n2)c1
|
COc1cccc(-c2nnn(CCCCOc3cccc([N+](=O)[O-])c3)n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C7C4"
}
|
Can you make molecule COc1cccc(-c2nnn(CCOc3cccc([N+](=O)[O-])c3)n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-c2nnn(CCCCCOc3cccc([N+](=O)[O-])c3)n2)c1
|
COc1cccc(-c2nnn(CCOc3cccc([N+](=O)[O-])c3)n2)c1
|
COc1cccc(-c2nnn(CCCCCOc3cccc([N+](=O)[O-])c3)n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C7C4"
}
|
Can you make molecule COc1cccc(-c2nnn(CCOc3cccc([N+](=O)[O-])c3)n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-c2nnn(C3CC(Oc4cccc([N+](=O)[O-])c4)C3)n2)c1
|
COc1cccc(-c2nnn(CCOc3cccc([N+](=O)[O-])c3)n2)c1
|
COc1cccc(-c2nnn(C3CC(Oc4cccc([N+](=O)[O-])c4)C3)n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C7C4"
}
|
Can you make molecule COc1cccc(-c2nnn(CCOc3cccc([N+](=O)[O-])c3)n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-c2nnn(C3CCN(Oc4cccc([N+](=O)[O-])c4)CC3)n2)c1
|
COc1cccc(-c2nnn(CCOc3cccc([N+](=O)[O-])c3)n2)c1
|
COc1cccc(-c2nnn(C3CCN(Oc4cccc([N+](=O)[O-])c4)CC3)n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCN&CC1",
"old_substring": "C7C4"
}
|
Can you make molecule COc1cccc(-c2nnn(CCOc3cccc([N+](=O)[O-])c3)n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-c2nnn([C@@H](C)CCOc3cccc([N+](=O)[O-])c3)n2)c1
|
COc1cccc(-c2nnn(CCOc3cccc([N+](=O)[O-])c3)n2)c1
|
COc1cccc(-c2nnn([C@@H](C)CCOc3cccc([N+](=O)[O-])c3)n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C7C4"
}
|
Can you make molecule O=C(NCc1cccnc1)c1ccc(CSc2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sc1ccc(CSc2ccccc2)cc1)NCc1cccnc1
|
O=C(NCc1cccnc1)c1ccc(CSc2ccccc2)cc1
|
O=C(/C=C/Sc1ccc(CSc2ccccc2)cc1)NCc1cccnc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C36"
}
|
Can you make molecule O=C(NCc1cccnc1)c1ccc(CSc2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(NCc2cccnc2)nc1-c1ccc(CSc2ccccc2)cc1
|
O=C(NCc1cccnc1)c1ccc(CSc2ccccc2)cc1
|
O=Cc1sc(NCc2cccnc2)nc1-c1ccc(CSc2ccccc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C36"
}
|
Can you make molecule O=C(NCc1cccnc1)c1ccc(CSc2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(NCc2cccnc2)sc1-c1ccc(CSc2ccccc2)cc1
|
O=C(NCc1cccnc1)c1ccc(CSc2ccccc2)cc1
|
O=Cc1nc(NCc2cccnc2)sc1-c1ccc(CSc2ccccc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C36"
}
|
Can you make molecule O=C(NCc1cccnc1)c1ccc(CSc2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCc1cccnc1)n1nc(-c2ccc(CSc3ccccc3)cc2)oc1=S
|
O=C(NCc1cccnc1)c1ccc(CSc2ccccc2)cc1
|
O=C(NCc1cccnc1)n1nc(-c2ccc(CSc3ccccc3)cc2)oc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&n1nc&oc1=S",
"old_substring": "O=C36"
}
|
Can you make molecule O=C(NCc1cccnc1)c1ccc(CSc2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C(=N/ONCc1cccnc1)\c1ccc(-c2ccc(CSc3ccccc3)cc2)o1
|
O=C(NCc1cccnc1)c1ccc(CSc2ccccc2)cc1
|
C(=N/ONCc1cccnc1)\c1ccc(-c2ccc(CSc3ccccc3)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C36"
}
|
Can you make molecule CCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
|
CCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
|
CC(C)CC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC4"
}
|
Can you make molecule CCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Clc1nc2ccccn2c1CN1CCC[NH+](CCCCBr)CC1
|
CCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
|
Clc1nc2ccccn2c1CN1CCC[NH+](CCCCBr)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC4"
}
|
Can you make molecule CCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
|
CCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
|
C=CCCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC4"
}
|
Can you make molecule CCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
ClCCCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
|
CCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
|
ClCCCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC4"
}
|
Can you make molecule CCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
|
CCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
|
C=CCCCC[NH+]1CCCN(Cc2c(Cl)nc3ccccn23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CCC4"
}
|
Can you make molecule CC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CO)=NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
|
CC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
|
CCC(CO)=NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&CO",
"old_substring": "CC4=O"
}
|
Can you make molecule CC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
|
CC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
|
CCCC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&=O",
"old_substring": "CC4=O"
}
|
Can you make molecule CC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)SNC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
|
CC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
|
CC(=O)SNC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CC4=O"
}
|
Can you make molecule CC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
|
CC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
|
CCCCC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CC4=O"
}
|
Can you make molecule CC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C=O)=NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
|
CC(=O)NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
|
CCC(C=O)=NC[C@H]1CCCN(C(=O)NCC2(c3ccccc3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&C=O",
"old_substring": "CC4=O"
}
|
Can you make molecule Fc1ccccc1-c1cnc(CNC2CC[NH+](Cc3ccccc3)CC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccccc1-c1cnc(CNC2CCN(Cc3ccccc3)CC2)s1
|
Fc1ccccc1-c1cnc(CNC2CC[NH+](Cc3ccccc3)CC2)s1
|
Fc1ccccc1-c1cnc(CNC2CCN(Cc3ccccc3)CC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCN&CC1",
"old_substring": "C16CC[NH+]5CC1"
}
|
Can you make molecule Fc1ccccc1-c1cnc(CNC2CC[NH+](Cc3ccccc3)CC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccccc1-c1cnc(CNC2CCC(Cc3ccccc3)CC2)s1
|
Fc1ccccc1-c1cnc(CNC2CC[NH+](Cc3ccccc3)CC2)s1
|
Fc1ccccc1-c1cnc(CNC2CCC(Cc3ccccc3)CC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C16CC[NH+]5CC1"
}
|
Can you make molecule Fc1ccccc1-c1cnc(CNC2CC[NH+](Cc3ccccc3)CC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccccc1-c1cnc(CNC2CC(Cc3ccccc3)C2)s1
|
Fc1ccccc1-c1cnc(CNC2CC[NH+](Cc3ccccc3)CC2)s1
|
Fc1ccccc1-c1cnc(CNC2CC(Cc3ccccc3)C2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C16CC[NH+]5CC1"
}
|
Can you make molecule Fc1ccccc1-c1cnc(CNC2CC[NH+](Cc3ccccc3)CC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CN(NCc2ncc(-c3ccccc3F)s2)CCN1Cc1ccccc1
|
Fc1ccccc1-c1cnc(CNC2CC[NH+](Cc3ccccc3)CC2)s1
|
C[C@@H]1CN(NCc2ncc(-c3ccccc3F)s2)CCN1Cc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN&[C@H](C)C1",
"old_substring": "C16CC[NH+]5CC1"
}
|
Can you make molecule Fc1ccccc1-c1cnc(CNC2CC[NH+](Cc3ccccc3)CC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccccc1-c1cnc(CNCC2=CN=N[C@H]2Cc2ccccc2)s1
|
Fc1ccccc1-c1cnc(CNC2CC[NH+](Cc3ccccc3)CC2)s1
|
Fc1ccccc1-c1cnc(CNCC2=CN=N[C@H]2Cc2ccccc2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(C&)[C@H]&N=N1",
"old_substring": "C16CC[NH+]5CC1"
}
|
Can you make molecule Cc1nc(N2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(N2CCCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
|
Cc1nc(N2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
|
Cc1nc(N2CCCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC1",
"old_substring": "N16CCOCC1"
}
|
Can you make molecule Cc1nc(N2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(N2CCCCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
|
Cc1nc(N2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
|
Cc1nc(N2CCCCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCC1",
"old_substring": "N16CCOCC1"
}
|
Can you make molecule Cc1nc(N2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(N2CCSCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
|
Cc1nc(N2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
|
Cc1nc(N2CCSCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSCC1",
"old_substring": "N16CCOCC1"
}
|
Can you make molecule Cc1nc(N2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(N2CC=CC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
|
Cc1nc(N2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
|
Cc1nc(N2CC=CC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC=CC1",
"old_substring": "N16CCOCC1"
}
|
Can you make molecule Cc1nc(N2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(SSN2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
|
Cc1nc(N2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
|
Cc1nc(SSN2CCOCC2)c2c(C(=O)N3CCc4ccccc43)c(C)oc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SN1CCOCC1",
"old_substring": "N16CCOCC1"
}
|
Can you make molecule O=C(CNC(=O)c1ccc[nH]c1=O)Nc1ccon1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CNSC(=O)Cc1ccc[nH]c1=O)Nc1ccon1
|
O=C(CNC(=O)c1ccc[nH]c1=O)Nc1ccon1
|
O=C(CNSC(=O)Cc1ccc[nH]c1=O)Nc1ccon1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule O=C(CNC(=O)c1ccc[nH]c1=O)Nc1ccon1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCC(=O)c1ccc[nH]c1=O)NCC(=O)Nc1ccon1
|
O=C(CNC(=O)c1ccc[nH]c1=O)Nc1ccon1
|
O=C(CCCC(=O)c1ccc[nH]c1=O)NCC(=O)Nc1ccon1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
}
|
Can you make molecule O=C(CNC(=O)c1ccc[nH]c1=O)Nc1ccon1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)NCC(=O)Nc1ccon1)c1ccc[nH]c1=O
|
O=C(CNC(=O)c1ccc[nH]c1=O)Nc1ccon1
|
CC(C)(CC(=O)NCC(=O)Nc1ccon1)c1ccc[nH]c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule O=C(CNC(=O)c1ccc[nH]c1=O)Nc1ccon1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)NCC(=O)Nc1ccon1)c1ccc[nH]c1=O
|
O=C(CNC(=O)c1ccc[nH]c1=O)Nc1ccon1
|
CC(C)(CCC(=O)NCC(=O)Nc1ccon1)c1ccc[nH]c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule O=C(CNC(=O)c1ccc[nH]c1=O)Nc1ccon1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SNCC(=O)Nc1ccon1)c1ccc[nH]c1=O
|
O=C(CNC(=O)c1ccc[nH]c1=O)Nc1ccon1
|
C[C@H](C(=O)SNCC(=O)Nc1ccon1)c1ccc[nH]c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(F)c2)CC3)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cc4cc(F)ccc4s2)CC3)c(C)c1
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(F)c2)CC3)c(C)c1
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cc4cc(F)ccc4s2)CC3)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cc(F)ccc2s1",
"old_substring": "c16cccc(F)c1"
}
|
Can you make molecule Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(F)c2)CC3)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(Br)c2C)CC3)c(C)c1
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(F)c2)CC3)c(C)c1
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(Br)c2C)CC3)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(Br)c1C",
"old_substring": "c16cccc(F)c1"
}
|
Can you make molecule Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(F)c2)CC3)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2oc4ccc(F)cc4c2C)CC3)c(C)c1
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(F)c2)CC3)c(C)c1
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2oc4ccc(F)cc4c2C)CC3)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&oc2ccc(F)cc2c1C",
"old_substring": "c16cccc(F)c1"
}
|
Can you make molecule Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(F)c2)CC3)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cc(F)ccc2Br)CC3)c(C)c1
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(F)c2)CC3)c(C)c1
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cc(F)ccc2Br)CC3)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1Br",
"old_substring": "c16cccc(F)c1"
}
|
Can you make molecule Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(F)c2)CC3)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2ccc(F)cc2Cl)CC3)c(C)c1
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2cccc(F)c2)CC3)c(C)c1
|
Cc1cc(C)c(S(=O)(=O)N2CCOC23CCN(C(=O)c2ccc(F)cc2Cl)CC3)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c16cccc(F)c1"
}
|
Can you make molecule COc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
|
COc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
|
COCc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
|
COc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
|
COCSc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
|
COc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
|
CC(=O)Sc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(N[C@H]1CCCC[C@H]1O)c1ccc(C(=O)CS)c(O)c1
|
COc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
|
O=C(N[C@H]1CCCC[C@H]1O)c1ccc(C(=O)CS)c(O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(N[C@H]1CCCC[C@H]1O)c1ccc(C(=O)CI)c(O)c1
|
COc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
|
O=C(N[C@H]1CCCC[C@H]1O)c1ccc(C(=O)CI)c(O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO4"
}
|
Can you make molecule Cc1nn(-c2ccc(F)cc2F)c(C)c1[C@@H]1NC(=O)[C@@H]2COCCN21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(C)c([C@@H]2NC(=O)[C@@H]3COCCN32)cc1-c1ccc(F)cc1F
|
Cc1nn(-c2ccc(F)cc2F)c(C)c1[C@@H]1NC(=O)[C@@H]2COCCN21
|
Cc1nc(C)c([C@@H]2NC(=O)[C@@H]3COCCN32)cc1-c1ccc(F)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nc(C)c&cc1&",
"old_substring": "Cc1nn3c(C)c14"
}
|
Can you make molecule Cc1nn(-c2ccc(F)cc2F)c(C)c1[C@@H]1NC(=O)[C@@H]2COCCN21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(-c2ccc(F)cc2F)c2sc([C@@H]3NC(=O)[C@@H]4COCCN43)cc12
|
Cc1nn(-c2ccc(F)cc2F)c(C)c1[C@@H]1NC(=O)[C@@H]2COCCN21
|
Cc1nn(-c2ccc(F)cc2F)c2sc([C@@H]3NC(=O)[C@@H]4COCCN43)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nn&c2sc&cc12",
"old_substring": "Cc1nn3c(C)c14"
}
|
Can you make molecule Cc1nn(-c2ccc(F)cc2F)c(C)c1[C@@H]1NC(=O)[C@@H]2COCCN21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(F)cc2F)nc([C@@H]2NC(=O)[C@@H]3COCCN32)c1Br
|
Cc1nn(-c2ccc(F)cc2F)c(C)c1[C@@H]1NC(=O)[C@@H]2COCCN21
|
Cc1nc(-c2ccc(F)cc2F)nc([C@@H]2NC(=O)[C@@H]3COCCN32)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nc&nc&c1Br",
"old_substring": "Cc1nn3c(C)c14"
}
|
Can you make molecule Cc1nn(-c2ccc(F)cc2F)c(C)c1[C@@H]1NC(=O)[C@@H]2COCCN21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1[nH]c(=O)c(-c2ccc(F)cc2F)cc1[C@@H]1NC(=O)[C@@H]2COCCN21
|
Cc1nn(-c2ccc(F)cc2F)c(C)c1[C@@H]1NC(=O)[C@@H]2COCCN21
|
Cc1[nH]c(=O)c(-c2ccc(F)cc2F)cc1[C@@H]1NC(=O)[C@@H]2COCCN21
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1[nH]c(=O)c&cc1&",
"old_substring": "Cc1nn3c(C)c14"
}
|
Can you make molecule Cc1nn(-c2ccc(F)cc2F)c(C)c1[C@@H]1NC(=O)[C@@H]2COCCN21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(-c2ccc(F)cc2F)c(C)n1[C@@H]1NC(=O)[C@@H]2COCCN12
|
Cc1nn(-c2ccc(F)cc2F)c(C)c1[C@@H]1NC(=O)[C@@H]2COCCN21
|
Cc1cc(-c2ccc(F)cc2F)c(C)n1[C@@H]1NC(=O)[C@@H]2COCCN12
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&c(C)n1&",
"old_substring": "Cc1nn3c(C)c14"
}
|
Can you make molecule NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1cccc(CNSC(=O)C[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
|
NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
|
NC(=O)c1cccc(CNSC(=O)C[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1cccc(CNCC(=C=O)C[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
|
NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
|
NC(=O)c1cccc(CNCC(=C=O)C[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1cccc(CNC(=O)CCCC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
|
NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
|
NC(=O)c1cccc(CNC(=O)CCCC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)NCc1cccc(C(N)=O)c1)[C@@H]1C[C@@H]2C=C[C@H]1C2
|
NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
|
CC(C)(CC(=O)NCc1cccc(C(N)=O)c1)[C@@H]1C[C@@H]2C=C[C@H]1C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1cccc(CNC[S@+]([O-])CCC[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
|
NC(=O)c1cccc(CNC(=O)[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
|
NC(=O)c1cccc(CNC[S@+]([O-])CCC[C@@H]2C[C@@H]3C=C[C@H]2C3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C46=O"
}
|
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