prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O
|
CCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O
|
CC(C)CCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC4"
}
|
Can you make molecule CCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C[C@@H]1Nc2ccccc2NC1=O)Nc1ccccc1OCCCCBr
|
CCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O
|
O=C(C[C@@H]1Nc2ccccc2NC1=O)Nc1ccccc1OCCCCBr
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC4"
}
|
Can you make molecule CCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O
|
CCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O
|
C=CCCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC4"
}
|
Can you make molecule CCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C[C@@H]1Nc2ccccc2NC1=O)Nc1ccccc1OCCCCCl
|
CCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O
|
O=C(C[C@@H]1Nc2ccccc2NC1=O)Nc1ccccc1OCCCCCl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC4"
}
|
Can you make molecule CCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O
|
CCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O
|
C=CCCCCOc1ccccc1NC(=O)C[C@@H]1Nc2ccccc2NC1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CCC4"
}
|
Can you make molecule COC[C@@H](C)NC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@@H](C)NSC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
|
COC[C@@H](C)NC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
|
COC[C@@H](C)NSC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C4(=O)C7"
}
|
Can you make molecule COC[C@@H](C)NC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@@H](C)NC(=O)CCCC(=O)[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
|
COC[C@@H](C)NC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
|
COC[C@@H](C)NC(=O)CCCC(=O)[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C4(=O)C7"
}
|
Can you make molecule COC[C@@H](C)NC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@@H](C)NC(=O)CC(C)(C)[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
|
COC[C@@H](C)NC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
|
COC[C@@H](C)NC(=O)CC(C)(C)[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C4(=O)C7"
}
|
Can you make molecule COC[C@@H](C)NC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@@H](C)NC[S@+]([O-])CCC[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
|
COC[C@@H](C)NC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
|
COC[C@@H](C)NC[S@+]([O-])CCC[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C4(=O)C7"
}
|
Can you make molecule COC[C@@H](C)NC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC[C@@H](C)NC(=O)CCC(C)(C)[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
|
COC[C@@H](C)NC(=O)C[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
|
COC[C@@H](C)NC(=O)CCC(C)(C)[NH+]1CCc2sc(-c3csc(C)n3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C4(=O)C7"
}
|
Can you make molecule Cc1cccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)cc1I
|
Cc1cccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1
|
Cc1ccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "Cc1cccc6c1"
}
|
Can you make molecule Cc1cccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)cc1Cl
|
Cc1cccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1
|
Cc1ccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1Cl",
"old_substring": "Cc1cccc6c1"
}
|
Can you make molecule Cc1cccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(I)ccc1OC[C@H](C)NC(=O)C(=O)Nc1cccc(C#N)c1
|
Cc1cccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1
|
Cc1cc(I)ccc1OC[C@H](C)NC(=O)C(=O)Nc1cccc(C#N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(I)ccc1&",
"old_substring": "Cc1cccc6c1"
}
|
Can you make molecule Cc1cccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(I)c(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1
|
Cc1cccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1
|
Cc1ccc(I)c(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(I)c&c1",
"old_substring": "Cc1cccc6c1"
}
|
Can you make molecule Cc1cccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Br)c(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1
|
Cc1cccc(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1
|
Cc1ccc(Br)c(OC[C@H](C)NC(=O)C(=O)Nc2cccc(C#N)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(Br)c&c1",
"old_substring": "Cc1cccc6c1"
}
|
Can you make molecule C[C@H]1CN(Cc2ccccc2)CCN1C(=O)NCC(C)(C)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(Cc2ccccc2Cl)CCN1C(=O)NCC(C)(C)N1CCOCC1
|
C[C@H]1CN(Cc2ccccc2)CCN1C(=O)NCC(C)(C)N1CCOCC1
|
C[C@H]1CN(Cc2ccccc2Cl)CCN1C(=O)NCC(C)(C)N1CCOCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c18ccccc1"
}
|
Can you make molecule C[C@H]1CN(Cc2ccccc2)CCN1C(=O)NCC(C)(C)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(Cc2ccc(I)cc2)CCN1C(=O)NCC(C)(C)N1CCOCC1
|
C[C@H]1CN(Cc2ccccc2)CCN1C(=O)NCC(C)(C)N1CCOCC1
|
C[C@H]1CN(Cc2ccc(I)cc2)CCN1C(=O)NCC(C)(C)N1CCOCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c18ccccc1"
}
|
Can you make molecule C[C@H]1CN(Cc2ccccc2)CCN1C(=O)NCC(C)(C)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CN2CCN(C(=O)NCC(C)(C)N3CCOCC3)[C@@H](C)C2)cc1I
|
C[C@H]1CN(Cc2ccccc2)CCN1C(=O)NCC(C)(C)N1CCOCC1
|
Cc1ccc(CN2CCN(C(=O)NCC(C)(C)N3CCOCC3)[C@@H](C)C2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c18ccccc1"
}
|
Can you make molecule C[C@H]1CN(Cc2ccccc2)CCN1C(=O)NCC(C)(C)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(Cc2cccc(Br)c2)CCN1C(=O)NCC(C)(C)N1CCOCC1
|
C[C@H]1CN(Cc2ccccc2)CCN1C(=O)NCC(C)(C)N1CCOCC1
|
C[C@H]1CN(Cc2cccc(Br)c2)CCN1C(=O)NCC(C)(C)N1CCOCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c18ccccc1"
}
|
Can you make molecule C[C@H]1CN(Cc2ccccc2)CCN1C(=O)NCC(C)(C)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(CN2CCN(C(=O)NCC(C)(C)N3CCOCC3)[C@@H](C)C2)c1C
|
C[C@H]1CN(Cc2ccccc2)CCN1C(=O)NCC(C)(C)N1CCOCC1
|
Cc1cccc(CN2CCN(C(=O)NCC(C)(C)N3CCOCC3)[C@@H](C)C2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c18ccccc1"
}
|
Can you make molecule COc1cc(OC)c(NC(=O)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(OC)c(NC(=O)CC(C)(C)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl
|
COc1cc(OC)c(NC(=O)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl
|
COc1cc(OC)c(NC(=O)CC(C)(C)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule COc1cc(OC)c(NC(=O)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(OC)c(NC(=O)CCC(C)(C)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl
|
COc1cc(OC)c(NC(=O)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl
|
COc1cc(OC)c(NC(=O)CCC(C)(C)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule COc1cc(OC)c(NC(=O)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(OC)c(NC(=O)C[C@@H](Br)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl
|
COc1cc(OC)c(NC(=O)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl
|
COc1cc(OC)c(NC(=O)C[C@@H](Br)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C45=O"
}
|
Can you make molecule COc1cc(OC)c(NC(=O)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(OC)c(Nc2cc(C)n(Nc3c(-c4cccnc4)[nH]c4ccccc34)c(=O)c2)cc1Cl
|
COc1cc(OC)c(NC(=O)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl
|
COc1cc(OC)c(Nc2cc(C)n(Nc3c(-c4cccnc4)[nH]c4ccccc34)c(=O)c2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C45=O"
}
|
Can you make molecule COc1cc(OC)c(NC(=O)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(OC)c(Nc2c(C)n(Nc3c(-c4cccnc4)[nH]c4ccccc34)ccc2=O)cc1Cl
|
COc1cc(OC)c(NC(=O)Nc2c(-c3cccnc3)[nH]c3ccccc23)cc1Cl
|
COc1cc(OC)c(Nc2c(C)n(Nc3c(-c4cccnc4)[nH]c4ccccc34)ccc2=O)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C45=O"
}
|
Can you make molecule Cc1ccc2nc3c(cc(C(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc3c(cc(CC(=O)SNCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
|
Cc1ccc2nc3c(cc(C(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
|
Cc1ccc2nc3c(cc(CC(=O)SNCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C57=O"
}
|
Can you make molecule Cc1ccc2nc3c(cc(C(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc3c(cc(C(=O)CCCC(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
|
Cc1ccc2nc3c(cc(C(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
|
Cc1ccc2nc3c(cc(C(=O)CCCC(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C57=O"
}
|
Can you make molecule Cc1ccc2nc3c(cc(C(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc3c(cc(C(C)(C)CC(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
|
Cc1ccc2nc3c(cc(C(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
|
Cc1ccc2nc3c(cc(C(C)(C)CC(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C57=O"
}
|
Can you make molecule Cc1ccc2nc3c(cc(C(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc3c(cc(C(C)(C)CCC(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
|
Cc1ccc2nc3c(cc(C(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
|
Cc1ccc2nc3c(cc(C(C)(C)CCC(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C57=O"
}
|
Can you make molecule Cc1ccc2nc3c(cc(C(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc3c(cc([C@H](C)C(=O)SNCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
|
Cc1ccc2nc3c(cc(C(=O)NCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
|
Cc1ccc2nc3c(cc([C@H](C)C(=O)SNCCc4ccccc4)c(N)[n+]3Cc3ccncc3)c(=O)n2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C57=O"
}
|
Can you make molecule COc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
|
COc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
|
COCc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
|
COc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
|
COCSc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
|
COc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
|
CC(=O)Sc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccccc1C(=O)CS)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
|
COc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
|
O=C(Nc1ccccc1C(=O)CS)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccccc1C(=O)CI)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
|
COc1ccccc1NC(=O)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
|
O=C(Nc1ccccc1C(=O)CI)c1cc2c(cc1Cl)N1CCCCCC1=NS2(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO4"
}
|
Can you make molecule CCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F
|
CCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F
|
C=CSc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC5"
}
|
Can you make molecule CCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F
|
CCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F
|
CC(C)c1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC5"
}
|
Can you make molecule CCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F
|
CCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F
|
C=CCCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC5"
}
|
Can you make molecule CCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1ccc(CCCCl)c(S(=O)(=O)[N-]c2ccc(F)c(F)c2F)c1
|
CCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F
|
O=C([O-])c1ccc(CCCCl)c(S(=O)(=O)[N-]c2ccc(F)c(F)c2F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC5"
}
|
Can you make molecule CCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1ccc(CCCCS)c(S(=O)(=O)[N-]c2ccc(F)c(F)c2F)c1
|
CCc1ccc(C(=O)[O-])cc1S(=O)(=O)[N-]c1ccc(F)c(F)c1F
|
O=C([O-])c1ccc(CCCCS)c(S(=O)(=O)[N-]c2ccc(F)c(F)c2F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC5"
}
|
Can you make molecule CCOc1cc(C=C2C(=O)ON=C2C)cc(Cl)c1OCc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C=C2SC(S)=NC2=O)cc(Cl)c1OCc1cccc(F)c1
|
CCOc1cc(C=C2C(=O)ON=C2C)cc(Cl)c1OCc1cccc(F)c1
|
CCOc1cc(C=C2SC(S)=NC2=O)cc(Cl)c1OCc1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&SC(S)=NC1=O",
"old_substring": "C1=7C(=O)ON=C1C"
}
|
Can you make molecule CCOc1cc(C=C2C(=O)ON=C2C)cc(Cl)c1OCc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C=C2C=CC(=O)C=C2)cc(Cl)c1OCc1cccc(F)c1
|
CCOc1cc(C=C2C(=O)ON=C2C)cc(Cl)c1OCc1cccc(F)c1
|
CCOc1cc(C=C2C=CC(=O)C=C2)cc(Cl)c1OCc1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&C=CC(=O)C=C1",
"old_substring": "C1=7C(=O)ON=C1C"
}
|
Can you make molecule CCOc1cc(C=C2C(=O)ON=C2C)cc(Cl)c1OCc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C=C2N=C(SC)SC2=O)cc(Cl)c1OCc1cccc(F)c1
|
CCOc1cc(C=C2C(=O)ON=C2C)cc(Cl)c1OCc1cccc(F)c1
|
CCOc1cc(C=C2N=C(SC)SC2=O)cc(Cl)c1OCc1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&N=C(SC)SC1=O",
"old_substring": "C1=7C(=O)ON=C1C"
}
|
Can you make molecule CCOc1cc(C=C2C(=O)ON=C2C)cc(Cl)c1OCc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C=C2CCC(=O)CC2)cc(Cl)c1OCc1cccc(F)c1
|
CCOc1cc(C=C2C(=O)ON=C2C)cc(Cl)c1OCc1cccc(F)c1
|
CCOc1cc(C=C2CCC(=O)CC2)cc(Cl)c1OCc1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCC(=O)CC1",
"old_substring": "C1=7C(=O)ON=C1C"
}
|
Can you make molecule CCOc1cc(C=C2C(=O)ON=C2C)cc(Cl)c1OCc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1cc(C=C2CCOCC2)cc(Cl)c1OCc1cccc(F)c1
|
CCOc1cc(C=C2C(=O)ON=C2C)cc(Cl)c1OCc1cccc(F)c1
|
CCOc1cc(C=C2CCOCC2)cc(Cl)c1OCc1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCOCC1",
"old_substring": "C1=7C(=O)ON=C1C"
}
|
Can you make molecule Cc1ccc(O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(SC(=S)O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
|
Cc1ccc(O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
|
Cc1ccc(SC(=S)O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "O35"
}
|
Can you make molecule Cc1ccc(O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CC(=N)O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
|
Cc1ccc(O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
|
Cc1ccc(CC(=N)O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=N)C&",
"old_substring": "O35"
}
|
Can you make molecule Cc1ccc(O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)CCC(=O)[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
|
Cc1ccc(O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
|
Cc1ccc(C(=O)CCC(=O)[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&CCC&=O",
"old_substring": "O35"
}
|
Can you make molecule Cc1ccc(O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CC[C@@H](O)[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
|
Cc1ccc(O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
|
Cc1ccc(CC[C@@H](O)[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@@H]&CC&",
"old_substring": "O35"
}
|
Can you make molecule Cc1ccc(O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(S/C=C/C(=O)[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
|
Cc1ccc(O[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
|
Cc1ccc(S/C=C/C(=O)[C@@H](C)C(=O)NNC(=O)COc2ccccc2Cl)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O35"
}
|
Can you make molecule CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)NCCCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1
|
CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1
|
CC(C)C(=O)NCCCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C3C4"
}
|
Can you make molecule CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)N=CCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1
|
CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1
|
CC(C)C(=O)N=CCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC&",
"old_substring": "C3C4"
}
|
Can you make molecule CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)NCCCCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1
|
CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1
|
CC(C)C(=O)NCCCCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C3C4"
}
|
Can you make molecule CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)NC1CC([NH2+][C@@H](C)C[C@@H]2CCCCC[NH2+]2)C1
|
CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1
|
CC(C)C(=O)NC1CC([NH2+][C@@H](C)C[C@@H]2CCCCC[NH2+]2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C3C4"
}
|
Can you make molecule CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(CC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1)=NC(=O)C(C)C
|
CC(C)C(=O)NCC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1
|
CC(CC[NH2+][C@@H](C)C[C@@H]1CCCCC[NH2+]1)=NC(=O)C(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&(C)CC&",
"old_substring": "C3C4"
}
|
Can you make molecule CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CC[C@H](CSCNC(=O)N[C@H]2CCOC2)c2ccccc21
|
CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21
|
CC1(C)CC[C@H](CSCNC(=O)N[C@H]2CCOC2)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N35"
}
|
Can you make molecule CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CC[C@H](CC2CN(C(=O)N[C@H]3CCOC3)C2)c2ccccc21
|
CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21
|
CC1(C)CC[C@H](CC2CN(C(=O)N[C@H]3CCOC3)C2)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC&C1",
"old_substring": "N35"
}
|
Can you make molecule CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CC[C@H](CSC(=N)NC(=O)N[C@H]2CCOC2)c2ccccc21
|
CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21
|
CC1(C)CC[C@H](CSC(=N)NC(=O)N[C@H]2CCOC2)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N35"
}
|
Can you make molecule CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)N[C@H]1CCOC1)C(=S)SC[C@H]1CCC(C)(C)c2ccccc21
|
CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21
|
CN(C(=O)N[C@H]1CCOC1)C(=S)SC[C@H]1CCC(C)(C)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N35"
}
|
Can you make molecule CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)CC[C@H](CSC2=NCCN2C(=O)N[C@H]2CCOC2)c2ccccc21
|
CC1(C)CC[C@H](CNC(=O)N[C@H]2CCOC2)c2ccccc21
|
CC1(C)CC[C@H](CSC2=NCCN2C(=O)N[C@H]2CCOC2)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N35"
}
|
Can you make molecule C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2)CS1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2I)CS1
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2)CS1
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2I)CS1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1I",
"old_substring": "c13ccc(Cl)cc1"
}
|
Can you make molecule C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2)CS1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2Br)CS1
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2)CS1
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2Br)CS1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1Br",
"old_substring": "c13ccc(Cl)cc1"
}
|
Can you make molecule C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2)CS1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)c(I)c2)CS1
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2)CS1
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)c(I)c2)CS1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(I)c1",
"old_substring": "c13ccc(Cl)cc1"
}
|
Can you make molecule C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2)CS1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2cc(Cl)ccc2Cl)CS1
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2)CS1
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2cc(Cl)ccc2Cl)CS1
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1ccc(Cl)c&c1",
"old_substring": "c13ccc(Cl)cc1"
}
|
Can you make molecule C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2)CS1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)c(Cl)c2)CS1
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)cc2)CS1
|
C[C@@H]1C[C@]2(C[NH+]=C(N)N2c2ccc(Cl)c(Cl)c2)CS1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Cl)c1",
"old_substring": "c13ccc(Cl)cc1"
}
|
Can you make molecule Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCCCC2)CC1
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCC1",
"old_substring": "N13CCCC1"
}
|
Can you make molecule Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCCCCC2)CC1
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCCCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCC1",
"old_substring": "N13CCCC1"
}
|
Can you make molecule Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCC(C)CC2)CC1
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCC(C)CC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC(C)CC1",
"old_substring": "N13CCCC1"
}
|
Can you make molecule Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCCCCCC2)CC1
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCCCCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCCC1",
"old_substring": "N13CCCC1"
}
|
Can you make molecule Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCCCCC2=O)CC1
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCC2)CC1
|
Cc1ccsc1CN1CCN([C@@H](C)C(=O)N2CCCCCCC2=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCC1=O",
"old_substring": "N13CCCC1"
}
|
Can you make molecule Cc1cc(NC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NSC(=O)Cc2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
|
Cc1cc(NC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
|
Cc1cc(NSC(=O)Cc2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1cc(NC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)CCCC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
|
Cc1cc(NC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
|
Cc1cc(NC(=O)CCCC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1cc(NC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)CC(C)(C)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
|
Cc1cc(NC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
|
Cc1cc(NC(=O)CC(C)(C)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1cc(NC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NC(=O)CCC(C)(C)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
|
Cc1cc(NC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
|
Cc1cc(NC(=O)CCC(C)(C)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1cc(NC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NSC(=O)[C@@H](C)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
|
Cc1cc(NC(=O)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
|
Cc1cc(NSC(=O)[C@@H](C)c2cc(C)n(C(C)C)c2C)ccc1N1CC[NH+](C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C36=O"
}
|
Can you make molecule CC(C)C[C@@H](C[NH+](C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@@H](C[NH+]1CCCC1(C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1
|
CC(C)C[C@@H](C[NH+](C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1
|
CC(C)C[C@@H](C[NH+]1CCCC1(C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCCC1(C)C",
"old_substring": "[NH+]6(C)C"
}
|
Can you make molecule CC(C)C[C@@H](C[NH+](C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@@H](C[N+](C)(C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1
|
CC(C)C[C@@H](C[NH+](C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1
|
CC(C)C[C@@H](C[N+](C)(C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[N+]&(C)C",
"old_substring": "[NH+]6(C)C"
}
|
Can you make molecule CC(C)C[C@@H](C[NH+](C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@@H](C[NH+]1CC(C)(C)C1)NC(=O)N1CCC([NH+]2CCCC2)CC1
|
CC(C)C[C@@H](C[NH+](C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1
|
CC(C)C[C@@H](C[NH+]1CC(C)(C)C1)NC(=O)N1CCC([NH+]2CCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC(C)(C)C1",
"old_substring": "[NH+]6(C)C"
}
|
Can you make molecule CC(C)C[C@@H](C[NH+](C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@@H](C[NH+]1CC2(CC2)C1)NC(=O)N1CCC([NH+]2CCCC2)CC1
|
CC(C)C[C@@H](C[NH+](C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1
|
CC(C)C[C@@H](C[NH+]1CC2(CC2)C1)NC(=O)N1CCC([NH+]2CCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC2(CC2)C1",
"old_substring": "[NH+]6(C)C"
}
|
Can you make molecule CC(C)C[C@@H](C[NH+](C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C[C@@H](C[NH+]1CCC(C)(C)C1)NC(=O)N1CCC([NH+]2CCCC2)CC1
|
CC(C)C[C@@H](C[NH+](C)C)NC(=O)N1CCC([NH+]2CCCC2)CC1
|
CC(C)C[C@@H](C[NH+]1CCC(C)(C)C1)NC(=O)N1CCC([NH+]2CCCC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC(C)(C)C1",
"old_substring": "[NH+]6(C)C"
}
|
Can you make molecule Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=O)cnc3ccccc32)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=S)sc3ccccc32)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=O)cnc3ccccc32)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=S)sc3ccccc32)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&c(=S)sc2ccccc21",
"old_substring": "n14c(=O)cnc2ccccc21"
}
|
Can you make molecule Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=O)cnc3ccccc32)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2ccc(=S)c3ccccc32)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=O)cnc3ccccc32)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2ccc(=S)c3ccccc32)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccc(=S)c2ccccc21",
"old_substring": "n14c(=O)cnc2ccccc21"
}
|
Can you make molecule Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=O)cnc3ccccc32)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2ccc3c(Cl)cccc32)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=O)cnc3ccccc32)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2ccc3c(Cl)cccc32)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccc2c(Cl)cccc21",
"old_substring": "n14c(=O)cnc2ccccc21"
}
|
Can you make molecule Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=O)cnc3ccccc32)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2ccc(=O)c3sccc32)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=O)cnc3ccccc32)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2ccc(=O)c3sccc32)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccc(=O)c2sccc21",
"old_substring": "n14c(=O)cnc2ccccc21"
}
|
Can you make molecule Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=O)cnc3ccccc32)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])C=Cc2cn(C)c3ccccc23)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])Cn2c(=O)cnc3ccccc32)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])C=Cc2cn(C)c3ccccc23)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1cc(C=&)c2ccccc21",
"old_substring": "n14c(=O)cnc2ccccc21"
}
|
Can you make molecule C[C@@]1(CO)c2ccccc2O[C@H]1n1nnc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@]1(CO)c2ccccc2O[C@H]1c1nc2cccnc2s1
|
C[C@@]1(CO)c2ccccc2O[C@H]1n1nnc2ccccc21
|
C[C@@]1(CO)c2ccccc2O[C@H]1c1nc2cccnc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2cccnc2s1",
"old_substring": "n13nnc2ccccc21"
}
|
Can you make molecule C[C@@]1(CO)c2ccccc2O[C@H]1n1nnc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@]1(CO)c2ccccc2O[C@H]1c1nc2cnccc2s1
|
C[C@@]1(CO)c2ccccc2O[C@H]1n1nnc2ccccc21
|
C[C@@]1(CO)c2ccccc2O[C@H]1c1nc2cnccc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2cnccc2s1",
"old_substring": "n13nnc2ccccc21"
}
|
Can you make molecule C[C@@]1(CO)c2ccccc2O[C@H]1n1nnc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@]1(CO)c2ccccc2O[C@H]1n1cc2ccccc2c1
|
C[C@@]1(CO)c2ccccc2O[C@H]1n1nnc2ccccc21
|
C[C@@]1(CO)c2ccccc2O[C@H]1n1cc2ccccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc2ccccc2c1",
"old_substring": "n13nnc2ccccc21"
}
|
Can you make molecule C[C@@]1(CO)c2ccccc2O[C@H]1n1nnc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1nc([C@@H]2Oc3ccccc3[C@@]2(C)CO)c2ccccc21
|
C[C@@]1(CO)c2ccccc2O[C@H]1n1nnc2ccccc21
|
Cn1nc([C@@H]2Oc3ccccc3[C@@]2(C)CO)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1nc&c2ccccc21",
"old_substring": "n13nnc2ccccc21"
}
|
Can you make molecule C[C@@]1(CO)c2ccccc2O[C@H]1n1nnc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn2ccccc2c1[C@@H]1Oc2ccccc2[C@@]1(C)CO
|
C[C@@]1(CO)c2ccccc2O[C@H]1n1nnc2ccccc21
|
Cc1nn2ccccc2c1[C@@H]1Oc2ccccc2[C@@]1(C)CO
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nn2ccccc2c1&",
"old_substring": "n13nnc2ccccc21"
}
|
Can you make molecule CCC[C@@H]([NH3+])C(=O)N[C@@H]1CCSc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H]([NH3+])CCN[C@@H]1CCSc2ccccc21
|
CCC[C@@H]([NH3+])C(=O)N[C@@H]1CCSc2ccccc21
|
CCC[C@H]([NH3+])CCN[C@@H]1CCSc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]([NH3+])CC3",
"old_substring": "CCC[C@@H]([NH3+])C3=O"
}
|
Can you make molecule CCC[C@@H]([NH3+])C(=O)N[C@@H]1CCSc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H]([NH3+])CN[C@@H]1CCSc2ccccc21
|
CCC[C@@H]([NH3+])C(=O)N[C@@H]1CCSc2ccccc21
|
CCCC[C@H]([NH3+])CN[C@@H]1CCSc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]([NH3+])C3",
"old_substring": "CCC[C@@H]([NH3+])C3=O"
}
|
Can you make molecule CCC[C@@H]([NH3+])C(=O)N[C@@H]1CCSc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C[NH3+])=N[C@@H]1CCSc2ccccc21
|
CCC[C@@H]([NH3+])C(=O)N[C@@H]1CCSc2ccccc21
|
CCC(C[NH3+])=N[C@@H]1CCSc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=3C[NH3+]",
"old_substring": "CCC[C@@H]([NH3+])C3=O"
}
|
Can you make molecule CCC[C@@H]([NH3+])C(=O)N[C@@H]1CCSc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC([NH3+])(CC)N[C@@H]1CCSc2ccccc21
|
CCC[C@@H]([NH3+])C(=O)N[C@@H]1CCSc2ccccc21
|
CCC([NH3+])(CC)N[C@@H]1CCSc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC3([NH3+])CC",
"old_substring": "CCC[C@@H]([NH3+])C3=O"
}
|
Can you make molecule CCC[C@@H]([NH3+])C(=O)N[C@@H]1CCSc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C[NH3+])(CCC)N[C@@H]1CCSc2ccccc21
|
CCC[C@@H]([NH3+])C(=O)N[C@@H]1CCSc2ccccc21
|
CCCC(C[NH3+])(CCC)N[C@@H]1CCSc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC3(C[NH3+])CCC",
"old_substring": "CCC[C@@H]([NH3+])C3=O"
}
|
Can you make molecule CC[C@H](C#N)Oc1ccc(CO)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C#N)c1ccc(O)c(-c2ccc(CO)nc2)c2onc1-2
|
CC[C@H](C#N)Oc1ccc(CO)nc1
|
CC[C@H](C#N)c1ccc(O)c(-c2ccc(CO)nc2)c2onc1-2
| 102
|
{
"fragment_index": 0,
"new_substring": "Oc1ccc2c&noc2c1&",
"old_substring": "O23"
}
|
Can you make molecule CC[C@H](C#N)Oc1ccc(CO)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C#N)N1CCOc2ccc(-c3ccc(CO)nc3)cc2C1
|
CC[C@H](C#N)Oc1ccc(CO)nc1
|
CC[C@H](C#N)N1CCOc2ccc(-c3ccc(CO)nc3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1",
"old_substring": "O23"
}
|
Can you make molecule CC[C@H](C#N)Oc1ccc(CO)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C#N)c1cc2ccc-2ncn(-c2ccc(CO)nc2)c1=O
|
CC[C@H](C#N)Oc1ccc(CO)nc1
|
CC[C@H](C#N)c1cc2ccc-2ncn(-c2ccc(CO)nc2)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cc&ccc2ncn1&",
"old_substring": "O23"
}
|
Can you make molecule CC[C@H](C#N)Oc1ccc(CO)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C#N)c1ccc2nc-2ccn(-c2ccc(CO)nc2)c1=O
|
CC[C@H](C#N)Oc1ccc(CO)nc1
|
CC[C@H](C#N)c1ccc2nc-2ccn(-c2ccc(CO)nc2)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2ccc&nc2ccn1&",
"old_substring": "O23"
}
|
Can you make molecule CC[C@H](C#N)Oc1ccc(CO)nc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C#N)c1cnc2nc-2ccn(-c2ccc(CO)nc2)c1=O
|
CC[C@H](C#N)Oc1ccc(CO)nc1
|
CC[C@H](C#N)c1cnc2nc-2ccn(-c2ccc(CO)nc2)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cnc&nc2ccn1&",
"old_substring": "O23"
}
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.