prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CC[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCCl)Cc1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
|
CC[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
|
CC[C@@H](CCCl)Cc1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H](C&)CCCl",
"old_substring": "CC[C@H]6C"
}
|
Can you make molecule CC[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](CCCl)Cc1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
|
CC[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
|
CC[C@H](CCCl)Cc1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](C&)CCCl",
"old_substring": "CC[C@H]6C"
}
|
Can you make molecule CC[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cl)CCCc1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
|
CC[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
|
CC[C@@H](Cl)CCCc1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](Cl)CCC&",
"old_substring": "CC[C@H]6C"
}
|
Can you make molecule CC[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C)C[C@H](CC)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
|
CC[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
|
CC[C@@H](C)C[C@H](CC)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H]&C[C@H](C)CC",
"old_substring": "CC[C@H]6C"
}
|
Can you make molecule CC[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cl)[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
|
CC[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
|
CC[C@@H](Cl)[C@@H](C)c1noc([C@@H]2CCCN(C(=O)C3CCCC3)C2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](Cl)[C@H]&C",
"old_substring": "CC[C@H]6C"
}
|
Can you make molecule O=C(Cc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1
|
O=C(Cc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1
|
O=C(/C=C/Sc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C4C6"
}
|
Can you make molecule O=C(Cc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(c2noc3ccccc23)CC1)Nc1ccc(-n2cnc3ccccc32)cc1
|
O=C(Cc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1
|
O=C(NN=C1CCC(c2noc3ccccc23)CC1)Nc1ccc(-n2cnc3ccccc32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C4C6"
}
|
Can you make molecule O=C(Cc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\ONc1ccc(-n2cnc3ccccc32)cc1)C(=O)Sc1noc2ccccc12
|
O=C(Cc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1
|
C/C(=N\ONc1ccc(-n2cnc3ccccc32)cc1)C(=O)Sc1noc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)C(=O)S&",
"old_substring": "O=C4C6"
}
|
Can you make molecule O=C(Cc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(-n2cnc3ccccc32)cc1)C1=CC[C@H](c2noc3ccccc23)S1
|
O=C(Cc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1
|
O=C(Nc1ccc(-n2cnc3ccccc32)cc1)C1=CC[C@H](c2noc3ccccc23)S1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&C1=CC[C@H]&S1",
"old_substring": "O=C4C6"
}
|
Can you make molecule O=C(Cc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=Cc1ccc(-c2noc3ccccc23)cc1)Nc1ccc(-n2cnc3ccccc32)cc1
|
O=C(Cc1noc2ccccc12)Nc1ccc(-n2cnc3ccccc32)cc1
|
O=C(NN=Cc1ccc(-c2noc3ccccc23)cc1)Nc1ccc(-n2cnc3ccccc32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=Cc1ccc&cc1",
"old_substring": "O=C4C6"
}
|
Can you make molecule Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2)c2ccccc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2I)c2ccccc23)c1
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2)c2ccccc23)c1
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2I)c2ccccc23)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1I",
"old_substring": "c15ccc(Cl)cc1"
}
|
Can you make molecule Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2)c2ccccc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2Br)c2ccccc23)c1
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2)c2ccccc23)c1
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2Br)c2ccccc23)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1Br",
"old_substring": "c15ccc(Cl)cc1"
}
|
Can you make molecule Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2)c2ccccc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)c(I)c2)c2ccccc23)c1
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2)c2ccccc23)c1
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)c(I)c2)c2ccccc23)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(I)c1",
"old_substring": "c15ccc(Cl)cc1"
}
|
Can you make molecule Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2)c2ccccc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2cc(Cl)ccc2Cl)c2ccccc23)c1
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2)c2ccccc23)c1
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2cc(Cl)ccc2Cl)c2ccccc23)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1ccc(Cl)c&c1",
"old_substring": "c15ccc(Cl)cc1"
}
|
Can you make molecule Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2)c2ccccc23)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccccc23)c1
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)cc2)c2ccccc23)c1
|
Cc1cccc([C@H]2C(C#N)=C(N)OC3=C2S(=O)(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccccc23)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Cl)c1",
"old_substring": "c15ccc(Cl)cc1"
}
|
Can you make molecule Cc1ccc(-c2ncc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2ncc3c(=O)n(CCC(CO)=Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1
|
Cc1ccc(-c2ncc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1
|
Cc1ccc(-c2ncc3c(=O)n(CCC(CO)=Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C7C5=O"
}
|
Can you make molecule Cc1ccc(-c2ncc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(Cn1c(=O)c2cnc(-c3ccc(C)cc3)nc2n(C)c1=O)=N/ONc1ccc(C(C)C)cc1
|
Cc1ccc(-c2ncc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1
|
C/C(Cn1c(=O)c2cnc(-c3ccc(C)cc3)nc2n(C)c1=O)=N/ONc1ccc(C(C)C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C7C5=O"
}
|
Can you make molecule Cc1ccc(-c2ncc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CNc1ccc(C(C)C)cc1)n1c(=O)c2cnc(-c3ccc(C)cc3)nc2n(C)c1=O
|
Cc1ccc(-c2ncc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1
|
CCC(CC)(C(=O)CNc1ccc(C(C)C)cc1)n1c(=O)c2cnc(-c3ccc(C)cc3)nc2n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C7C5=O"
}
|
Can you make molecule Cc1ccc(-c2ncc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2ncc3c(=O)n(SSC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1
|
Cc1ccc(-c2ncc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1
|
Cc1ccc(-c2ncc3c(=O)n(SSC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C7C5=O"
}
|
Can you make molecule Cc1ccc(-c2ncc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CCNc1ccc(C(C)C)cc1)n1c(=O)c2cnc(-c3ccc(C)cc3)nc2n(C)c1=O
|
Cc1ccc(-c2ncc3c(=O)n(CC(=O)Nc4ccc(C(C)C)cc4)c(=O)n(C)c3n2)cc1
|
CCC(CC)(C(=O)CCNc1ccc(C(C)C)cc1)n1c(=O)c2cnc(-c3ccc(C)cc3)nc2n(C)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C7C5=O"
}
|
Can you make molecule COc1ccccc1N(CCC#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C#N)(CC)N(C(=O)[C@H](C)N1CCO[C@@H](C)C1)c1ccccc1OC
|
COc1ccccc1N(CCC#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1
|
CCC(C#N)(CC)N(C(=O)[C@H](C)N1CCO[C@@H](C)C1)c1ccccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(C#N)CC",
"old_substring": "C4CC#N"
}
|
Can you make molecule COc1ccccc1N(CCC#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C#N)(CCC)N(C(=O)[C@H](C)N1CCO[C@@H](C)C1)c1ccccc1OC
|
COc1ccccc1N(CCC#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1
|
CCCC(C#N)(CCC)N(C(=O)[C@H](C)N1CCO[C@@H](C)C1)c1ccccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&(C#N)CCC",
"old_substring": "C4CC#N"
}
|
Can you make molecule COc1ccccc1N(CCC#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1N(CCC(C)(C)C#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1
|
COc1ccccc1N(CCC#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1
|
COc1ccccc1N(CCC(C)(C)C#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C#N)CC&",
"old_substring": "C4CC#N"
}
|
Can you make molecule COc1ccccc1N(CCC#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C#N)(CC)C(=O)N(C(=O)[C@H](C)N1CCO[C@@H](C)C1)c1ccccc1OC
|
COc1ccccc1N(CCC#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1
|
CCC(C#N)(CC)C(=O)N(C(=O)[C@H](C)N1CCO[C@@H](C)C1)c1ccccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(C#N)(CC)C&=O",
"old_substring": "C4CC#N"
}
|
Can you make molecule COc1ccccc1N(CCC#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H](C#N)C(=O)N(C(=O)[C@H](C)N1CCO[C@@H](C)C1)c1ccccc1OC
|
COc1ccccc1N(CCC#N)C(=O)[C@H](C)N1CCO[C@@H](C)C1
|
CCC[C@H](C#N)C(=O)N(C(=O)[C@H](C)N1CCO[C@@H](C)C1)c1ccccc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H](C#N)C&=O",
"old_substring": "C4CC#N"
}
|
Can you make molecule COCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.
|
COCSCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C
|
COCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C
|
COCSCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)SCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C
|
COCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C
|
CC(=O)SCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.
|
CN1C(=O)C2=NC(CNCCC(=O)CI)=N[C@@H]2N(C)C1=O
|
COCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C
|
CN1C(=O)C2=NC(CNCCC(=O)CI)=N[C@@H]2N(C)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
}
|
Can you make molecule COCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.
|
CN1C(=O)C2=NC(CNCCC3OCCCO3)=N[C@@H]2N(C)C1=O
|
COCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C
|
CN1C(=O)C2=NC(CNCCC3OCCCO3)=N[C@@H]2N(C)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&OCCCO1",
"old_substring": "CO3"
}
|
Can you make molecule COCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.
|
CN1C(=O)C2=NC(CNCCC(=O)CCl)=N[C@@H]2N(C)C1=O
|
COCCNCC1=N[C@H]2C(=N1)C(=O)N(C)C(=O)N2C
|
CN1C(=O)C2=NC(CNCCC(=O)CCl)=N[C@@H]2N(C)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCl",
"old_substring": "CO3"
}
|
Can you make molecule CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3)ccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3Cl)ccc12
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3)ccc12
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3Cl)ccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c18ccccc1"
}
|
Can you make molecule CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3)ccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccc(I)cc3)ccc12
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3)ccc12
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccc(I)cc3)ccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c18ccccc1"
}
|
Can you make molecule CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3)ccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccc(C)c(I)c3)ccc12
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3)ccc12
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccc(C)c(I)c3)ccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c18ccccc1"
}
|
Can you make molecule CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3)ccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3cccc(Br)c3)ccc12
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3)ccc12
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3cccc(Br)c3)ccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c18ccccc1"
}
|
Can you make molecule CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3)ccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3cccc(C)c3C)ccc12
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3ccccc3)ccc12
|
CCc1cc(=O)oc2c(C)c(OCC(=O)N(CCC#N)c3cccc(C)c3C)ccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c18ccccc1"
}
|
Can you make molecule CC1CC[NH+](C[C@H](O)COCCC23CC4CC(CC(C4)C2)C3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](C[C@H](O)COCCCCC23CC4CC(CC(C4)C2)C3)CC1
|
CC1CC[NH+](C[C@H](O)COCCC23CC4CC(CC(C4)C2)C3)CC1
|
CC1CC[NH+](C[C@H](O)COCCCCC23CC4CC(CC(C4)C2)C3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C6C8"
}
|
Can you make molecule CC1CC[NH+](C[C@H](O)COCCC23CC4CC(CC(C4)C2)C3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](C[C@H](O)COCCCCCC23CC4CC(CC(C4)C2)C3)CC1
|
CC1CC[NH+](C[C@H](O)COCCC23CC4CC(CC(C4)C2)C3)CC1
|
CC1CC[NH+](C[C@H](O)COCCCCCC23CC4CC(CC(C4)C2)C3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C6C8"
}
|
Can you make molecule CC1CC[NH+](C[C@H](O)COCCC23CC4CC(CC(C4)C2)C3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](C[C@H](O)CO[C@@H](C)CCC23CC4CC(CC(C4)C2)C3)CC1
|
CC1CC[NH+](C[C@H](O)COCCC23CC4CC(CC(C4)C2)C3)CC1
|
CC1CC[NH+](C[C@H](O)CO[C@@H](C)CCC23CC4CC(CC(C4)C2)C3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C6C8"
}
|
Can you make molecule CC1CC[NH+](C[C@H](O)COCCC23CC4CC(CC(C4)C2)C3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](C[C@H](O)COC2CCC(C34CC5CC(CC(C5)C3)C4)CC2)CC1
|
CC1CC[NH+](C[C@H](O)COCCC23CC4CC(CC(C4)C2)C3)CC1
|
CC1CC[NH+](C[C@H](O)COC2CCC(C34CC5CC(CC(C5)C3)C4)CC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C6C8"
}
|
Can you make molecule CC1CC[NH+](C[C@H](O)COCCC23CC4CC(CC(C4)C2)C3)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1CC[NH+](C[C@H](O)COCC(C)(C)CC23CC4CC(CC(C4)C2)C3)CC1
|
CC1CC[NH+](C[C@H](O)COCCC23CC4CC(CC(C4)C2)C3)CC1
|
CC1CC[NH+](C[C@H](O)COCC(C)(C)CC23CC4CC(CC(C4)C2)C3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C&)C&",
"old_substring": "C6C8"
}
|
Can you make molecule CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(CCl)=NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
|
CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
|
CC(CCl)=NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&CCl",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)=NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
|
CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
|
CCCC(C)=NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC=&C",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CCNS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
|
CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
|
CC(C)CCNS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CBr)=NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
|
CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
|
CCC(CBr)=NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&CBr",
"old_substring": "CC4C"
}
|
Can you make molecule CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCC1CCCC1)Nc1ccc(S(=O)(=O)NCCCCBr)cc1
|
CC(C)NS(=O)(=O)c1ccc(NC(=O)CCC2CCCC2)cc1
|
O=C(CCC1CCCC1)Nc1ccc(S(=O)(=O)NCCCCBr)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CC4C"
}
|
Can you make molecule O=C(Nc1ccccc1-n1cncn1)C1CCN(C(=O)C2CC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccccc1-n1cncn1)C1CCC(C(=O)C2CC2)CC1
|
O=C(Nc1ccccc1-n1cncn1)C1CCN(C(=O)C2CC2)CC1
|
O=C(Nc1ccccc1-n1cncn1)C1CCC(C(=O)C2CC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C16CCN4CC1"
}
|
Can you make molecule O=C(Nc1ccccc1-n1cncn1)C1CCN(C(=O)C2CC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C(=O)C2CC2)CCC(C(=O)Nc2ccccc2-n2cncn2)CC1
|
O=C(Nc1ccccc1-n1cncn1)C1CCN(C(=O)C2CC2)CC1
|
CC1(C(=O)C2CC2)CCC(C(=O)Nc2ccccc2-n2cncn2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&(C)CC1",
"old_substring": "C16CCN4CC1"
}
|
Can you make molecule O=C(Nc1ccccc1-n1cncn1)C1CCN(C(=O)C2CC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#CC1(C(=O)Nc2ccccc2-n2cncn2)CCC(C(=O)C2CC2)CC1
|
O=C(Nc1ccccc1-n1cncn1)C1CCN(C(=O)C2CC2)CC1
|
N#CC1(C(=O)Nc2ccccc2-n2cncn2)CCC(C(=O)C2CC2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCC&CC1",
"old_substring": "C16CCN4CC1"
}
|
Can you make molecule O=C(Nc1ccccc1-n1cncn1)C1CCN(C(=O)C2CC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCCCC(=O)C1CC1)Nc1ccccc1-n1cncn1
|
O=C(Nc1ccccc1-n1cncn1)C1CCN(C(=O)C2CC2)CC1
|
O=C(CCCCCC(=O)C1CC1)Nc1ccccc1-n1cncn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C16CCN4CC1"
}
|
Can you make molecule O=C(Nc1ccccc1-n1cncn1)C1CCN(C(=O)C2CC2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CC1=CCCN(C(=O)Nc2ccccc2-n2cncn2)C1)C1CC1
|
O=C(Nc1ccccc1-n1cncn1)C1CCN(C(=O)C2CC2)CC1
|
O=C(CC1=CCCN(C(=O)Nc2ccccc2-n2cncn2)C1)C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC=C(C&)C1",
"old_substring": "C16CCN4CC1"
}
|
Can you make molecule CCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1
|
CCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1
|
CC(C)CC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC6"
}
|
Can you make molecule CCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C1CC1)N(C)C(=O)N[C@@H]1C[C@H]1CCCCBr
|
CCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1
|
C[C@@H](C1CC1)N(C)C(=O)N[C@@H]1C[C@H]1CCCCBr
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC6"
}
|
Can you make molecule CCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1
|
CCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1
|
C=CCCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC6"
}
|
Can you make molecule CCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C1CC1)N(C)C(=O)N[C@@H]1C[C@H]1CCCCCl
|
CCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1
|
C[C@@H](C1CC1)N(C)C(=O)N[C@@H]1C[C@H]1CCCCCl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC6"
}
|
Can you make molecule CCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1
|
CCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1
|
C=CCCCC[C@@H]1C[C@H]1NC(=O)N(C)[C@@H](C)C1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CCC6"
}
|
Can you make molecule CC(C)Cn1nnnc1SCc1cc(=O)n2ccsc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Cn1nnnc1SCSCc1cc(=O)n2ccsc2n1
|
CC(C)Cn1nnnc1SCc1cc(=O)n2ccsc2n1
|
CC(C)Cn1nnnc1SCSCc1cc(=O)n2ccsc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&CS&",
"old_substring": "S36"
}
|
Can you make molecule CC(C)Cn1nnnc1SCc1cc(=O)n2ccsc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Cn1nnnc1-c1ccc2c(c1)N(Cc1cc(=O)n3ccsc3n1)CCS2
|
CC(C)Cn1nnnc1SCc1cc(=O)n2ccsc2n1
|
CC(C)Cn1nnnc1-c1ccc2c(c1)N(Cc1cc(=O)n3ccsc3n1)CCS2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "S36"
}
|
Can you make molecule CC(C)Cn1nnnc1SCc1cc(=O)n2ccsc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Cn1nnnc1N/C(C#N)=C(\Cl)SCc1cc(=O)n2ccsc2n1
|
CC(C)Cn1nnnc1SCc1cc(=O)n2ccsc2n1
|
CC(C)Cn1nnnc1N/C(C#N)=C(\Cl)SCc1cc(=O)n2ccsc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&/C(Cl)=C(\\C#N)N&",
"old_substring": "S36"
}
|
Can you make molecule CC(C)Cn1nnnc1SCc1cc(=O)n2ccsc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Cn1nnnc1-n1c(=S)n(Cc2cc(=O)n3ccsc3n2)c2ccccc21
|
CC(C)Cn1nnnc1SCc1cc(=O)n2ccsc2n1
|
CC(C)Cn1nnnc1-n1c(=S)n(Cc2cc(=O)n3ccsc3n2)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&c(=S)n&c2ccccc21",
"old_substring": "S36"
}
|
Can you make molecule CC(C)Cn1nnnc1SCc1cc(=O)n2ccsc2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Cn1nnnc1[C@H](C)[S@@+]([O-])CCCCc1cc(=O)n2ccsc2n1
|
CC(C)Cn1nnnc1SCc1cc(=O)n2ccsc2n1
|
CC(C)Cn1nnnc1[C@H](C)[S@@+]([O-])CCCCc1cc(=O)n2ccsc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC[S@](=O)[C@H]&C",
"old_substring": "S36"
}
|
Can you make molecule O=C(NC[C@H](O)CO)Nc1ccccc1N1CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/SNc1ccccc1N1CCc2ccccc21)NC[C@H](O)CO
|
O=C(NC[C@H](O)CO)Nc1ccccc1N1CCc2ccccc21
|
O=C(/C=C/SNc1ccccc1N1CCc2ccccc21)NC[C@H](O)CO
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(NC[C@H](O)CO)Nc1ccccc1N1CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C(=NC[C@H](O)CO)CCC1=Nc1ccccc1N1CCc2ccccc21
|
O=C(NC[C@H](O)CO)Nc1ccccc1N1CCc2ccccc21
|
O=C1C(=NC[C@H](O)CO)CCC1=Nc1ccccc1N1CCc2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1C=&CCC1=&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(NC[C@H](O)CO)Nc1ccccc1N1CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
OC[C@@H](O)CNO/N=C/c1ccc(Nc2ccccc2N2CCc3ccccc32)o1
|
O=C(NC[C@H](O)CO)Nc1ccccc1N1CCc2ccccc21
|
OC[C@@H](O)CNO/N=C/c1ccc(Nc2ccccc2N2CCc3ccccc32)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(NC[C@H](O)CO)Nc1ccccc1N1CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC[C@H](O)CO)NN=C1CCC(Nc2ccccc2N2CCc3ccccc32)CC1
|
O=C(NC[C@H](O)CO)Nc1ccccc1N1CCc2ccccc21
|
O=C(NC[C@H](O)CO)NN=C1CCC(Nc2ccccc2N2CCc3ccccc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(NC[C@H](O)CO)Nc1ccccc1N1CCc2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NC[C@H](O)CO)C1=CC[C@H](Nc2ccccc2N2CCc3ccccc32)S1
|
O=C(NC[C@H](O)CO)Nc1ccccc1N1CCc2ccccc21
|
O=C(NC[C@H](O)CO)C1=CC[C@H](Nc2ccccc2N2CCc3ccccc32)S1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&C1=CC[C@H]&S1",
"old_substring": "O=C34"
}
|
Can you make molecule CCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
|
CCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
|
CCCCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCC&=O",
"old_substring": "CCCC4=O"
}
|
Can you make molecule CCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
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CCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
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CCCCCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCCC&=O",
"old_substring": "CCCC4=O"
}
|
Can you make molecule CCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1 less soluble in water? The output molecule should be similar to the input molecule.
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CCCC(C)=Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
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CCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
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CCCC(C)=Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC=&C",
"old_substring": "CCCC4=O"
}
|
Can you make molecule CCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(CC)=NONc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
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CCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
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CCC(CC)=NONc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(CC)=NO&",
"old_substring": "CCCC4=O"
}
|
Can you make molecule CCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1 less soluble in water? The output molecule should be similar to the input molecule.
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CCCC(CCC)=Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
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CCCC(=O)Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
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CCCC(CCC)=Nc1nnc([C@@H]2CC(=O)N(c3ccc(SC)cc3)C2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC=&CCC",
"old_substring": "CCCC4=O"
}
|
Can you make molecule Cc1ccc(CC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1ccc(CCC(CO)=Nc2nnc(-c3ccc(C)cc3)o2)cc1
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Cc1ccc(CC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1
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Cc1ccc(CCC(CO)=Nc2nnc(-c3ccc(C)cc3)o2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C6C4=O"
}
|
Can you make molecule Cc1ccc(CC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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C/C(Cc1ccc(C)cc1)=N/ONc1nnc(-c2ccc(C)cc2)o1
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Cc1ccc(CC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1
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C/C(Cc1ccc(C)cc1)=N/ONc1nnc(-c2ccc(C)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C6C4=O"
}
|
Can you make molecule Cc1ccc(CC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(CC)(C(=O)CNc1nnc(-c2ccc(C)cc2)o1)c1ccc(C)cc1
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Cc1ccc(CC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1
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CCC(CC)(C(=O)CNc1nnc(-c2ccc(C)cc2)o1)c1ccc(C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C6C4=O"
}
|
Can you make molecule Cc1ccc(CC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1ccc(SSC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1
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Cc1ccc(CC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1
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Cc1ccc(SSC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C6C4=O"
}
|
Can you make molecule Cc1ccc(CC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(CC)(C(=O)CCNc1nnc(-c2ccc(C)cc2)o1)c1ccc(C)cc1
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Cc1ccc(CC(=O)Nc2nnc(-c3ccc(C)cc3)o2)cc1
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CCC(CC)(C(=O)CCNc1nnc(-c2ccc(C)cc2)o1)c1ccc(C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C6C4=O"
}
|
Can you make molecule CN(C)C(=O)O[C@@H]1CCCC[C@H]1C[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
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CN(C)C(=O)N1CCOc2ccc([C@@H]3CCCC[C@H]3C[NH3+])cc2C1
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CN(C)C(=O)O[C@@H]1CCCC[C@H]1C[NH3+]
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CN(C)C(=O)N1CCOc2ccc([C@@H]3CCCC[C@H]3C[NH3+])cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1",
"old_substring": "O24"
}
|
Can you make molecule CN(C)C(=O)O[C@@H]1CCCC[C@H]1C[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
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CN(C)C(=O)c1cc2ccc-2ncn([C@@H]2CCCC[C@H]2C[NH3+])c1=O
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CN(C)C(=O)O[C@@H]1CCCC[C@H]1C[NH3+]
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CN(C)C(=O)c1cc2ccc-2ncn([C@@H]2CCCC[C@H]2C[NH3+])c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2cc&ccc2ncn1&",
"old_substring": "O24"
}
|
Can you make molecule CN(C)C(=O)O[C@@H]1CCCC[C@H]1C[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
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CN(C)C(=O)c1ccc2nc-2ccn([C@@H]2CCCC[C@H]2C[NH3+])c1=O
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CN(C)C(=O)O[C@@H]1CCCC[C@H]1C[NH3+]
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CN(C)C(=O)c1ccc2nc-2ccn([C@@H]2CCCC[C@H]2C[NH3+])c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1c2ccc&nc2ccn1&",
"old_substring": "O24"
}
|
Can you make molecule CN(C)C(=O)O[C@@H]1CCCC[C@H]1C[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
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CN(C)C(=O)c1oc2ccc([C@@H]3CCCC[C@H]3C[NH3+])cc2c1C=O
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CN(C)C(=O)O[C@@H]1CCCC[C@H]1C[NH3+]
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CN(C)C(=O)c1oc2ccc([C@@H]3CCCC[C@H]3C[NH3+])cc2c1C=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1c&oc2ccc&cc12",
"old_substring": "O24"
}
|
Can you make molecule CN(C)C(=O)O[C@@H]1CCCC[C@H]1C[NH3+] less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)C(=O)N1CCOc2ccc([C@@H]3CCCC[C@H]3C[NH3+])cc2C1=O
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CN(C)C(=O)O[C@@H]1CCCC[C@H]1C[NH3+]
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CN(C)C(=O)N1CCOc2ccc([C@@H]3CCCC[C@H]3C[NH3+])cc2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccc&cc2C1=O",
"old_substring": "O24"
}
|
Can you make molecule CCC[NH2+]C[C@@]1(c2ccc(OC)c(OC)c2)CC[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
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CCC[NH2+]C[C@H]1CCC[C@H](c2ccc(OC)c(OC)c2)C1
|
CCC[NH2+]C[C@@]1(c2ccc(OC)c(OC)c2)CC[C@@H]1C
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CCC[NH2+]C[C@H]1CCC[C@H](c2ccc(OC)c(OC)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@]178CC[C@@H]1C"
}
|
Can you make molecule CCC[NH2+]C[C@@]1(c2ccc(OC)c(OC)c2)CC[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH2+]C[C@H]1CCCC[C@H](c2ccc(OC)c(OC)c2)C1
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CCC[NH2+]C[C@@]1(c2ccc(OC)c(OC)c2)CC[C@@H]1C
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CCC[NH2+]C[C@H]1CCCC[C@H](c2ccc(OC)c(OC)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@H]&C1",
"old_substring": "[C@]178CC[C@@H]1C"
}
|
Can you make molecule CCC[NH2+]C[C@@]1(c2ccc(OC)c(OC)c2)CC[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH2+]C[C@H]1CCC[C@H](c2ccc(OC)c(OC)c2)CC1
|
CCC[NH2+]C[C@@]1(c2ccc(OC)c(OC)c2)CC[C@@H]1C
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CCC[NH2+]C[C@H]1CCC[C@H](c2ccc(OC)c(OC)c2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&CC1",
"old_substring": "[C@]178CC[C@@H]1C"
}
|
Can you make molecule CCC[NH2+]C[C@@]1(c2ccc(OC)c(OC)c2)CC[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH2+]CCCC1=CCC[C@@H]1c1ccc(OC)c(OC)c1
|
CCC[NH2+]C[C@@]1(c2ccc(OC)c(OC)c2)CC[C@@H]1C
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CCC[NH2+]CCCC1=CCC[C@@H]1c1ccc(OC)c(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC1=CCC[C@@H]1&",
"old_substring": "[C@]178CC[C@@H]1C"
}
|
Can you make molecule CCC[NH2+]C[C@@]1(c2ccc(OC)c(OC)c2)CC[C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH2+]C[C@@H](CBr)CCCc1ccc(OC)c(OC)c1
|
CCC[NH2+]C[C@@]1(c2ccc(OC)c(OC)c2)CC[C@@H]1C
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CCC[NH2+]C[C@@H](CBr)CCCc1ccc(OC)c(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CBr)CCC&",
"old_substring": "[C@]178CC[C@@H]1C"
}
|
Can you make molecule C[C@H]1CC[C@H]([NH3+])[C@H](N2CC[NH+]3CCC[C@@H]3C2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)(C)N1CC[NH+]2CCC[C@@H]2C1
|
C[C@H]1CC[C@H]([NH3+])[C@H](N2CC[NH+]3CCC[C@@H]3C2)C1
|
CCCC(C)(C)N1CC[NH+]2CCC[C@@H]2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@H]1CC[C@H]([NH3+])[C@H]4C1"
}
|
Can you make molecule C[C@H]1CC[C@H]([NH3+])[C@H](N2CC[NH+]3CCC[C@@H]3C2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)CN1CC[NH+]2CCC[C@@H]2C1
|
C[C@H]1CC[C@H]([NH3+])[C@H](N2CC[NH+]3CCC[C@@H]3C2)C1
|
CC[C@H](C)CN1CC[NH+]2CCC[C@@H]2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&[C@H](C)C&",
"old_substring": "C[C@H]1CC[C@H]([NH3+])[C@H]4C1"
}
|
Can you make molecule C[C@H]1CC[C@H]([NH3+])[C@H](N2CC[NH+]3CCC[C@@H]3C2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCCN1N1CC[NH+]2CCC[C@@H]2C1
|
C[C@H]1CC[C@H]([NH3+])[C@H](N2CC[NH+]3CCC[C@@H]3C2)C1
|
C[C@@H]1CCCN1N1CC[NH+]2CCC[C@@H]2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]1[C@H]&CCN1&",
"old_substring": "C[C@H]1CC[C@H]([NH3+])[C@H]4C1"
}
|
Can you make molecule C[C@H]1CC[C@H]([NH3+])[C@H](N2CC[NH+]3CCC[C@@H]3C2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C1CCCC(N2CC[NH+]3CCC[C@@H]3C2)CC1
|
C[C@H]1CC[C@H]([NH3+])[C@H](N2CC[NH+]3CCC[C@@H]3C2)C1
|
C1CCCC(N2CC[NH+]3CCC[C@@H]3C2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&CC1",
"old_substring": "C[C@H]1CC[C@H]([NH3+])[C@H]4C1"
}
|
Can you make molecule C[C@H]1CC[C@H]([NH3+])[C@H](N2CC[NH+]3CCC[C@@H]3C2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C1CCC(N2CC[NH+]3CCC[C@@H]3C2)C1
|
C[C@H]1CC[C@H]([NH3+])[C@H](N2CC[NH+]3CCC[C@@H]3C2)C1
|
C1CCC(N2CC[NH+]3CCC[C@@H]3C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "C[C@H]1CC[C@H]([NH3+])[C@H]4C1"
}
|
Can you make molecule CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@H](C)C2)c1
|
CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1
|
CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@H](C)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC[C@H](C)C1",
"old_substring": "N13CC[C@@H](C)[C@H](O)C1"
}
|
Can you make molecule CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](Cl)C2)c1
|
CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1
|
CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](Cl)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC[C@@H](Cl)C1",
"old_substring": "N13CC[C@@H](C)[C@H](O)C1"
}
|
Can you make molecule CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cl)[C@@H](C)C(=O)c1cc(S(=O)(=O)CC)ccc1Cl
|
CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1
|
CC[C@@H](Cl)[C@@H](C)C(=O)c1cc(S(=O)(=O)CC)ccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](Cl)[C@H]&C",
"old_substring": "N13CC[C@@H](C)[C@H](O)C1"
}
|
Can you make molecule CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@H](Cl)C2)c1
|
CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1
|
CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@H](Cl)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC[C@H](Cl)C1",
"old_substring": "N13CC[C@@H](C)[C@H](O)C1"
}
|
Can you make molecule CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C)C(=O)CC(=O)c1cc(S(=O)(=O)CC)ccc1Cl
|
CCS(=O)(=O)c1ccc(Cl)c(C(=O)N2CC[C@@H](C)[C@H](O)C2)c1
|
CC[C@@H](C)C(=O)CC(=O)c1cc(S(=O)(=O)CC)ccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](C)C(=O)C&",
"old_substring": "N13CC[C@@H](C)[C@H](O)C1"
}
|
Can you make molecule Cc1nc([C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])c2ccccc2)n[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc([C@]2(c3ccccc3)CC[C@H](Nc3ccc(S(C)(=O)=O)cc3[N+](=O)[O-])C2)n[nH]1
|
Cc1nc([C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])c2ccccc2)n[nH]1
|
Cc1nc([C@]2(c3ccccc3)CC[C@H](Nc3ccc(S(C)(=O)=O)cc3[N+](=O)[O-])C2)n[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@]&&C1",
"old_substring": "[C@H]356"
}
|
Can you make molecule Cc1nc([C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])c2ccccc2)n[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc([C@@]2(c3ccccc3)CC[C@H](Nc3ccc(S(C)(=O)=O)cc3[N+](=O)[O-])C2)n[nH]1
|
Cc1nc([C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])c2ccccc2)n[nH]1
|
Cc1nc([C@@]2(c3ccccc3)CC[C@H](Nc3ccc(S(C)(=O)=O)cc3[N+](=O)[O-])C2)n[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@@]&&C1",
"old_substring": "[C@H]356"
}
|
Can you make molecule Cc1nc([C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])c2ccccc2)n[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CCC[C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])C(C)(C)c2ccccc2)n[nH]1
|
Cc1nc([C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])c2ccccc2)n[nH]1
|
Cc1nc(CCC[C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])C(C)(C)c2ccccc2)n[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CCC&)C&(C)C",
"old_substring": "[C@H]356"
}
|
Can you make molecule Cc1nc([C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])c2ccccc2)n[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc([C@]2(c3ccccc3)CCC[C@@H](Nc3ccc(S(C)(=O)=O)cc3[N+](=O)[O-])C2)n[nH]1
|
Cc1nc([C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])c2ccccc2)n[nH]1
|
Cc1nc([C@]2(c3ccccc3)CCC[C@@H](Nc3ccc(S(C)(=O)=O)cc3[N+](=O)[O-])C2)n[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCC[C@]&&C1",
"old_substring": "[C@H]356"
}
|
Can you make molecule Cc1nc([C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])c2ccccc2)n[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc([C@H]2CC(Nc3ccc(S(C)(=O)=O)cc3[N+](=O)[O-])C[C@@H](c3ccccc3)C2)n[nH]1
|
Cc1nc([C@H](Nc2ccc(S(C)(=O)=O)cc2[N+](=O)[O-])c2ccccc2)n[nH]1
|
Cc1nc([C@H]2CC(Nc3ccc(S(C)(=O)=O)cc3[N+](=O)[O-])C[C@@H](c3ccccc3)C2)n[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&C[C@H]&C[C@H]&C1",
"old_substring": "[C@H]356"
}
|
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