prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule O=C([O-])c1ccc(-c2c(F)cccc2F)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1cc(I)cc(-c2c(F)cccc2F)n1
|
O=C([O-])c1ccc(-c2c(F)cccc2F)cn1
|
O=C([O-])c1cc(I)cc(-c2c(F)cccc2F)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(I)cc&n1",
"old_substring": "c13ccc4cn1"
}
|
Can you make molecule O=C([O-])c1ccc(-c2c(F)cccc2F)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1cc(-c2c(F)cccc2F)cc(Cl)n1
|
O=C([O-])c1ccc(-c2c(F)cccc2F)cn1
|
O=C([O-])c1cc(-c2c(F)cccc2F)cc(Cl)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&cc(Cl)n1",
"old_substring": "c13ccc4cn1"
}
|
Can you make molecule O=C([O-])c1ccc(-c2c(F)cccc2F)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1cc(Cl)cc(-c2c(F)cccc2F)n1
|
O=C([O-])c1ccc(-c2c(F)cccc2F)cn1
|
O=C([O-])c1cc(Cl)cc(-c2c(F)cccc2F)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Cl)cc&n1",
"old_substring": "c13ccc4cn1"
}
|
Can you make molecule O=C([O-])c1ccc(-c2c(F)cccc2F)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1ncc(-c2c(F)cccc2F)cc1Cl
|
O=C([O-])c1ccc(-c2c(F)cccc2F)cn1
|
O=C([O-])c1ncc(-c2c(F)cccc2F)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc&cc1Cl",
"old_substring": "c13ccc4cn1"
}
|
Can you make molecule O=C([O-])c1ccc(-c2c(F)cccc2F)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])c1cc(-c2c(F)cccc2F)cnc1Cl
|
O=C([O-])c1ccc(-c2c(F)cccc2F)cn1
|
O=C([O-])c1cc(-c2c(F)cccc2F)cnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&cnc1Cl",
"old_substring": "c13ccc4cn1"
}
|
Can you make molecule CN(Cc1ncnn1C)C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1CN1CCC(C(=O)[C@@H]2C[C@H]2c2cccc(Cl)c2Cl)CC1
|
CN(Cc1ncnn1C)C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl
|
Cn1ncnc1CN1CCC(C(=O)[C@@H]2C[C@H]2c2cccc(Cl)c2Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCN&CC1",
"old_substring": "CN23"
}
|
Can you make molecule CN(Cc1ncnn1C)C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl)C(=S)SCc1ncnn1C
|
CN(Cc1ncnn1C)C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl
|
CN(C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl)C(=S)SCc1ncnn1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "CN23"
}
|
Can you make molecule CN(Cc1ncnn1C)C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1CC1CCN(CC(=O)[C@@H]2C[C@H]2c2cccc(Cl)c2Cl)CC1
|
CN(Cc1ncnn1C)C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl
|
Cn1ncnc1CC1CCN(CC(=O)[C@@H]2C[C@H]2c2cccc(Cl)c2Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "CN23"
}
|
Can you make molecule CN(Cc1ncnn1C)C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1CN1CN(C(=O)[C@@H]2C[C@H]2c2cccc(Cl)c2Cl)CSC1=S
|
CN(Cc1ncnn1C)C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl
|
Cn1ncnc1CN1CN(C(=O)[C@@H]2C[C@H]2c2cccc(Cl)c2Cl)CSC1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "S=C1SCN&CN1&",
"old_substring": "CN23"
}
|
Can you make molecule CN(Cc1ncnn1C)C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1CC1CCC(C#N)(C(=O)[C@@H]2C[C@H]2c2cccc(Cl)c2Cl)CC1
|
CN(Cc1ncnn1C)C(=O)[C@@H]1C[C@H]1c1cccc(Cl)c1Cl
|
Cn1ncnc1CC1CCC(C#N)(C(=O)[C@@H]2C[C@H]2c2cccc(Cl)c2Cl)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCC&CC1",
"old_substring": "CN23"
}
|
Can you make molecule Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Br)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(N=Cc1ccc(Cl)cc1Cl)c1ccc(Br)cc1
|
Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Br)cc1
|
O=S(=O)(N=Cc1ccc(Cl)cc1Cl)c1ccc(Br)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccc(Cl)cc1Cl",
"old_substring": "Cc1ccc(Cl)cc13"
}
|
Can you make molecule Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Br)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(Cl)cc(Cl)c1NS(=O)(=O)c1ccc(Br)cc1
|
Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Br)cc1
|
Cc1cc(Cl)cc(Cl)c1NS(=O)(=O)c1ccc(Br)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(Cl)cc(Cl)c1&",
"old_substring": "Cc1ccc(Cl)cc13"
}
|
Can you make molecule Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Br)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(Nc1ccc(Cl)cc1Br)c1ccc(Br)cc1
|
Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Br)cc1
|
O=S(=O)(Nc1ccc(Cl)cc1Br)c1ccc(Br)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1Br",
"old_substring": "Cc1ccc(Cl)cc13"
}
|
Can you make molecule Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Br)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=S(=O)(N=Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cc1
|
Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Br)cc1
|
O=S(=O)(N=Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccc(Cl)c(Cl)c1",
"old_substring": "Cc1ccc(Cl)cc13"
}
|
Can you make molecule Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Br)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(NS(=O)(=O)c2ccc(Br)cc2)c(Br)c(C)c1Cl
|
Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Br)cc1
|
Cc1cc(NS(=O)(=O)c2ccc(Br)cc2)c(Br)c(C)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&c(Br)c(C)c1Cl",
"old_substring": "Cc1ccc(Cl)cc13"
}
|
Can you make molecule COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC
|
COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC
|
COCc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "O4C"
}
|
Can you make molecule COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(C(=O)F)c1OC
|
COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC
|
COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(C(=O)F)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&F",
"old_substring": "O4C"
}
|
Can you make molecule COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC
|
COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC
|
COCSc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "O4C"
}
|
Can you make molecule COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OCCl)c1OC
|
COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC
|
COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OCCl)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "O&CCl",
"old_substring": "O4C"
}
|
Can you make molecule COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(C(=O)Cl)c1OC
|
COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(OC)c1OC
|
COc1cc(-c2nnc([S-])n2/N=C/c2sccc2C)cc(C(=O)Cl)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&Cl",
"old_substring": "O4C"
}
|
Can you make molecule CC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
|
CC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
|
CCCC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&=O",
"old_substring": "CC7=O"
}
|
Can you make molecule CC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
|
CC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
|
CCCCC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CC7=O"
}
|
Can you make molecule CC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)CCCc1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
|
CC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
|
CC(=O)CCCc1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)CCC&",
"old_substring": "CC7=O"
}
|
Can you make molecule CC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)CCCc1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
|
CC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
|
CCC(=O)CCCc1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(=O)CCC&",
"old_substring": "CC7=O"
}
|
Can you make molecule CC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)Cc1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
|
CC(=O)c1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
|
CCCCC(=O)Cc1ccc(NC(=O)C[C@@H]2C(=O)Nc3nc(-c4ccc(C)cc4)nn32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC(=O)C&",
"old_substring": "CC7=O"
}
|
Can you make molecule CCC[C@H](C[NH3+])[C@@]1(O)CCC[NH+](CC)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H]([NH3+])CC[C@@]1(O)CCC[NH+](CC)CC1
|
CCC[C@H](C[NH3+])[C@@]1(O)CCC[NH+](CC)CC1
|
CCC[C@H]([NH3+])CC[C@@]1(O)CCC[NH+](CC)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]([NH3+])CC3",
"old_substring": "CCC[C@@H]3C[NH3+]"
}
|
Can you make molecule CCC[C@H](C[NH3+])[C@@]1(O)CCC[NH+](CC)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H]([NH3+])C[C@@]1(O)CCC[NH+](CC)CC1
|
CCC[C@H](C[NH3+])[C@@]1(O)CCC[NH+](CC)CC1
|
CCCC[C@H]([NH3+])C[C@@]1(O)CCC[NH+](CC)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]([NH3+])C3",
"old_substring": "CCC[C@@H]3C[NH3+]"
}
|
Can you make molecule CCC[C@H](C[NH3+])[C@@]1(O)CCC[NH+](CC)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+]1CCC[C@](O)(CCCC(C)(C)[NH3+])CC1
|
CCC[C@H](C[NH3+])[C@@]1(O)CCC[NH+](CC)CC1
|
CC[NH+]1CCC[C@](O)(CCCC(C)(C)[NH3+])CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C3CCC(C)(C)[NH3+]",
"old_substring": "CCC[C@@H]3C[NH3+]"
}
|
Can you make molecule CCC[C@H](C[NH3+])[C@@]1(O)CCC[NH+](CC)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C[NH3+])(CCC)[C@@]1(O)CCC[NH+](CC)CC1
|
CCC[C@H](C[NH3+])[C@@]1(O)CCC[NH+](CC)CC1
|
CCCC(C[NH3+])(CCC)[C@@]1(O)CCC[NH+](CC)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC3(C[NH3+])CCC",
"old_substring": "CCC[C@@H]3C[NH3+]"
}
|
Can you make molecule CCC[C@H](C[NH3+])[C@@]1(O)CCC[NH+](CC)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+]1CCC[C@](O)(CC([NH3+])(CC)CC)CC1
|
CCC[C@H](C[NH3+])[C@@]1(O)CCC[NH+](CC)CC1
|
CC[NH+]1CCC[C@](O)(CC([NH3+])(CC)CC)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C3C([NH3+])(CC)CC",
"old_substring": "CCC[C@@H]3C[NH3+]"
}
|
Can you make molecule CN(Cc1ccsc1)C(=O)c1cccnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccsc1)SC(=O)Cc1cccnc1Cl
|
CN(Cc1ccsc1)C(=O)c1cccnc1Cl
|
CN(Cc1ccsc1)SC(=O)Cc1cccnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule CN(Cc1ccsc1)C(=O)c1cccnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccsc1)C(=O)CCCC(=O)c1cccnc1Cl
|
CN(Cc1ccsc1)C(=O)c1cccnc1Cl
|
CN(Cc1ccsc1)C(=O)CCCC(=O)c1cccnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C24=O"
}
|
Can you make molecule CN(Cc1ccsc1)C(=O)c1cccnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccsc1)C(=O)CC(C)(C)c1cccnc1Cl
|
CN(Cc1ccsc1)C(=O)c1cccnc1Cl
|
CN(Cc1ccsc1)C(=O)CC(C)(C)c1cccnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule CN(Cc1ccsc1)C(=O)c1cccnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccsc1)C(=O)CCC(C)(C)c1cccnc1Cl
|
CN(Cc1ccsc1)C(=O)c1cccnc1Cl
|
CN(Cc1ccsc1)C(=O)CCC(C)(C)c1cccnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule CN(Cc1ccsc1)C(=O)c1cccnc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SN(C)Cc1ccsc1)c1cccnc1Cl
|
CN(Cc1ccsc1)C(=O)c1cccnc1Cl
|
C[C@H](C(=O)SN(C)Cc1ccsc1)c1cccnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C24=O"
}
|
Can you make molecule C[C@H]1CN(CC(=O)Nc2ccc(OC(F)F)cc2)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(CC(=O)Nc2ccc(OC(F)(F)Cl)cc2)C[C@H](C)O1
|
C[C@H]1CN(CC(=O)Nc2ccc(OC(F)F)cc2)C[C@H](C)O1
|
C[C@H]1CN(CC(=O)Nc2ccc(OC(F)(F)Cl)cc2)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(F)(F)Cl",
"old_substring": "O4C(F)F"
}
|
Can you make molecule C[C@H]1CN(CC(=O)Nc2ccc(OC(F)F)cc2)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(CC(=O)Nc2ccc(C(F)(F)F)cc2)C[C@H](C)O1
|
C[C@H]1CN(CC(=O)Nc2ccc(OC(F)F)cc2)C[C@H](C)O1
|
C[C@H]1CN(CC(=O)Nc2ccc(C(F)(F)F)cc2)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "FC&(F)F",
"old_substring": "O4C(F)F"
}
|
Can you make molecule C[C@H]1CN(CC(=O)Nc2ccc(OC(F)F)cc2)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(CC(=O)Nc2ccc(SC(F)F)cc2)C[C@H](C)O1
|
C[C@H]1CN(CC(=O)Nc2ccc(OC(F)F)cc2)C[C@H](C)O1
|
C[C@H]1CN(CC(=O)Nc2ccc(SC(F)F)cc2)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)F",
"old_substring": "O4C(F)F"
}
|
Can you make molecule C[C@H]1CN(CC(=O)Nc2ccc(OC(F)F)cc2)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(CC(=O)Nc2ccc([C@@H](O)CC(F)(F)F)cc2)C[C@H](C)O1
|
C[C@H]1CN(CC(=O)Nc2ccc(OC(F)F)cc2)C[C@H](C)O1
|
C[C@H]1CN(CC(=O)Nc2ccc([C@@H](O)CC(F)(F)F)cc2)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@H]&CC(F)(F)F",
"old_substring": "O4C(F)F"
}
|
Can you make molecule C[C@H]1CN(CC(=O)Nc2ccc(OC(F)F)cc2)C[C@H](C)O1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CN(CC(=O)Nc2ccc(-c3c(F)cc(C=O)cc3F)cc2)C[C@H](C)O1
|
C[C@H]1CN(CC(=O)Nc2ccc(OC(F)F)cc2)C[C@H](C)O1
|
C[C@H]1CN(CC(=O)Nc2ccc(-c3c(F)cc(C=O)cc3F)cc2)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1cc(F)c&c(F)c1",
"old_substring": "O4C(F)F"
}
|
Can you make molecule Cc1sc2ncn3nc(CC#N)nc3c2c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1sc2ncn3nc(CCCC#N)nc3c2c1C
|
Cc1sc2ncn3nc(CC#N)nc3c2c1C
|
Cc1sc2ncn3nc(CCCC#N)nc3c2c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC#N",
"old_substring": "C4C#N"
}
|
Can you make molecule Cc1sc2ncn3nc(CC#N)nc3c2c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C#N)(CC)c1nc2c3c(C)c(C)sc3ncn2n1
|
Cc1sc2ncn3nc(CC#N)nc3c2c1C
|
CCC(C#N)(CC)c1nc2c3c(C)c(C)sc3ncn2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(C#N)CC",
"old_substring": "C4C#N"
}
|
Can you make molecule Cc1sc2ncn3nc(CC#N)nc3c2c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1sc2ncn3nc(C4(C#N)CCC4)nc3c2c1C
|
Cc1sc2ncn3nc(CC#N)nc3c2c1C
|
Cc1sc2ncn3nc(C4(C#N)CCC4)nc3c2c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCC1",
"old_substring": "C4C#N"
}
|
Can you make molecule Cc1sc2ncn3nc(CC#N)nc3c2c1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C#N)(CCC)c1nc2c3c(C)c(C)sc3ncn2n1
|
Cc1sc2ncn3nc(CC#N)nc3c2c1C
|
CCCC(C#N)(CCC)c1nc2c3c(C)c(C)sc3ncn2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&(C#N)CCC",
"old_substring": "C4C#N"
}
|
Can you make molecule Cc1sc2ncn3nc(CC#N)nc3c2c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1sc2ncn3nc(CCC(C)(C)C#N)nc3c2c1C
|
Cc1sc2ncn3nc(CC#N)nc3c2c1C
|
Cc1sc2ncn3nc(CCC(C)(C)C#N)nc3c2c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C#N)CC&",
"old_substring": "C4C#N"
}
|
Can you make molecule CCOC(=O)c1ccc(CNC(=O)NCC2(C)CCCC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1ccc(CSCNC(=O)NCC2(C)CCCC2)o1
|
CCOC(=O)c1ccc(CNC(=O)NCC2(C)CCCC2)o1
|
CCOC(=O)c1ccc(CSCNC(=O)NCC2(C)CCCC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N47"
}
|
Can you make molecule CCOC(=O)c1ccc(CNC(=O)NCC2(C)CCCC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1ccc(CSC(=N)NC(=O)NCC2(C)CCCC2)o1
|
CCOC(=O)c1ccc(CNC(=O)NCC2(C)CCCC2)o1
|
CCOC(=O)c1ccc(CSC(=N)NC(=O)NCC2(C)CCCC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N47"
}
|
Can you make molecule CCOC(=O)c1ccc(CNC(=O)NCC2(C)CCCC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1ccc(CSC(=S)N(C)C(=O)NCC2(C)CCCC2)o1
|
CCOC(=O)c1ccc(CNC(=O)NCC2(C)CCCC2)o1
|
CCOC(=O)c1ccc(CSC(=S)N(C)C(=O)NCC2(C)CCCC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N47"
}
|
Can you make molecule CCOC(=O)c1ccc(CNC(=O)NCC2(C)CCCC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1ccc(CSC2=NCCN2C(=O)NCC2(C)CCCC2)o1
|
CCOC(=O)c1ccc(CNC(=O)NCC2(C)CCCC2)o1
|
CCOC(=O)c1ccc(CSC2=NCCN2C(=O)NCC2(C)CCCC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N47"
}
|
Can you make molecule CCOC(=O)c1ccc(CNC(=O)NCC2(C)CCCC2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOC(=O)c1ccc(CC2CCN(CC(=O)NCC3(C)CCCC3)CC2)o1
|
CCOC(=O)c1ccc(CNC(=O)NCC2(C)CCCC2)o1
|
CCOC(=O)c1ccc(CC2CCN(CC(=O)NCC3(C)CCCC3)CC2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N47"
}
|
Can you make molecule COc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
|
COc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
|
COCc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
|
COc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
|
COCSc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
|
COc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
|
CC(=O)Sc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CS)c1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
|
COc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
|
O=C(CS)c1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CI)c1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
|
COc1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
|
O=C(CI)c1ccc(NC(=O)[C@H]2C[C@H]3CC[C@@H]2O3)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO5"
}
|
Can you make molecule COc1nn(C)cc1C(=O)N(Cc1ccccn1)c1nc2c(C)cccc2s1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1nc(C)nc(C(=O)N(Cc2ccccn2)c2nc3c(C)cccc3s2)c1C
|
COc1nn(C)cc1C(=O)N(Cc1ccccn1)c1nc2c(C)cccc2s1
|
COc1nc(C)nc(C(=O)N(Cc2ccccn2)c2nc3c(C)cccc3s2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc(C)nc&c1C",
"old_substring": "c14nn(C)cc17"
}
|
Can you make molecule COc1nn(C)cc1C(=O)N(Cc1ccccn1)c1nc2c(C)cccc2s1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1nc(Cl)nc(C(=O)N(Cc2ccccn2)c2nc3c(C)cccc3s2)c1C
|
COc1nn(C)cc1C(=O)N(Cc1ccccn1)c1nc2c(C)cccc2s1
|
COc1nc(Cl)nc(C(=O)N(Cc2ccccn2)c2nc3c(C)cccc3s2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc(Cl)nc&c1C",
"old_substring": "c14nn(C)cc17"
}
|
Can you make molecule COc1nn(C)cc1C(=O)N(Cc1ccccn1)c1nc2c(C)cccc2s1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1nc(Cl)nc(C(=O)N(Cc2ccccn2)c2nc3c(C)cccc3s2)c1Cl
|
COc1nn(C)cc1C(=O)N(Cc1ccccn1)c1nc2c(C)cccc2s1
|
COc1nc(Cl)nc(C(=O)N(Cc2ccccn2)c2nc3c(C)cccc3s2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc(Cl)nc&c1Cl",
"old_substring": "c14nn(C)cc17"
}
|
Can you make molecule COc1nn(C)cc1C(=O)N(Cc1ccccn1)c1nc2c(C)cccc2s1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1nnc(C(=O)N(Cc2ccccn2)c2nc3c(C)cccc3s2)c(C)c1C
|
COc1nn(C)cc1C(=O)N(Cc1ccccn1)c1nc2c(C)cccc2s1
|
COc1nnc(C(=O)N(Cc2ccccn2)c2nc3c(C)cccc3s2)c(C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nnc&c(C)c1C",
"old_substring": "c14nn(C)cc17"
}
|
Can you make molecule COc1nn(C)cc1C(=O)N(Cc1ccccn1)c1nc2c(C)cccc2s1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1nc(C)c(C(=O)N(Cc2ccccn2)c2nc3c(C)cccc3s2)s1
|
COc1nn(C)cc1C(=O)N(Cc1ccccn1)c1nc2c(C)cccc2s1
|
COc1nc(C)c(C(=O)N(Cc2ccccn2)c2nc3c(C)cccc3s2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc(C)c&s1",
"old_substring": "c14nn(C)cc17"
}
|
Can you make molecule CC(C)[NH+]1CCCN(C(=O)NCc2ccccc2C[NH+](C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[NH+]1CCCN(C(=O)CC(C)(C)NCc2ccccc2C[NH+](C)C)CC1
|
CC(C)[NH+]1CCCN(C(=O)NCc2ccccc2C[NH+](C)C)CC1
|
CC(C)[NH+]1CCCN(C(=O)CC(C)(C)NCc2ccccc2C[NH+](C)C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CC(C)[NH+]1CCCN(C(=O)NCc2ccccc2C[NH+](C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[NH+]1CCCN(C(=O)CCC(C)(C)NCc2ccccc2C[NH+](C)C)CC1
|
CC(C)[NH+]1CCCN(C(=O)NCc2ccccc2C[NH+](C)C)CC1
|
CC(C)[NH+]1CCCN(C(=O)CCC(C)(C)NCc2ccccc2C[NH+](C)C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CC(C)[NH+]1CCCN(C(=O)NCc2ccccc2C[NH+](C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[NH+]1CCCN(C(=O)C[C@@H](Br)NCc2ccccc2C[NH+](C)C)CC1
|
CC(C)[NH+]1CCCN(C(=O)NCc2ccccc2C[NH+](C)C)CC1
|
CC(C)[NH+]1CCCN(C(=O)C[C@@H](Br)NCc2ccccc2C[NH+](C)C)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule CC(C)[NH+]1CCCN(C(=O)NCc2ccccc2C[NH+](C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N2CCC[NH+](C(C)C)CC2)cc(=O)n1NCc1ccccc1C[NH+](C)C
|
CC(C)[NH+]1CCCN(C(=O)NCc2ccccc2C[NH+](C)C)CC1
|
Cc1cc(N2CCC[NH+](C(C)C)CC2)cc(=O)n1NCc1ccccc1C[NH+](C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C34=O"
}
|
Can you make molecule CC(C)[NH+]1CCCN(C(=O)NCc2ccccc2C[NH+](C)C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(N2CCC[NH+](C(C)C)CC2)c(=O)ccn1NCc1ccccc1C[NH+](C)C
|
CC(C)[NH+]1CCCN(C(=O)NCc2ccccc2C[NH+](C)C)CC1
|
Cc1c(N2CCC[NH+](C(C)C)CC2)c(=O)ccn1NCc1ccccc1C[NH+](C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C34=O"
}
|
Can you make molecule O=C(COc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/SOc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1
|
O=C(COc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1
|
O=C(/C=C/SOc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C2C3"
}
|
Can you make molecule O=C(COc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Clc1ccc(-n2cncn2)c(NON=C2CCN(Oc3c(Cl)cccc3Cl)CC2)c1
|
O=C(COc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1
|
Clc1ccc(-n2cncn2)c(NON=C2CCN(Oc3c(Cl)cccc3Cl)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "O=C2C3"
}
|
Can you make molecule O=C(COc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCN(Oc2c(Cl)cccc2Cl)CC1)Nc1cc(Cl)ccc1-n1cncn1
|
O=C(COc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1
|
O=C(NN=C1CCN(Oc2c(Cl)cccc2Cl)CC1)Nc1cc(Cl)ccc1-n1cncn1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCN&CC1",
"old_substring": "O=C2C3"
}
|
Can you make molecule O=C(COc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(Oc2c(Cl)cccc2Cl)CC1)Nc1cc(Cl)ccc1-n1cncn1
|
O=C(COc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1
|
O=C(NN=C1CCC(Oc2c(Cl)cccc2Cl)CC1)Nc1cc(Cl)ccc1-n1cncn1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C2C3"
}
|
Can you make molecule O=C(COc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\ONc1cc(Cl)ccc1-n1cncn1)C(=O)SOc1c(Cl)cccc1Cl
|
O=C(COc1c(Cl)cccc1Cl)Nc1cc(Cl)ccc1-n1cncn1
|
C/C(=N\ONc1cc(Cl)ccc1-n1cncn1)C(=O)SOc1c(Cl)cccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)C(=O)S&",
"old_substring": "O=C2C3"
}
|
Can you make molecule Cc1nc(-c2ccccn2)sc1C(=O)NC[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccccn2)sc1CC(=O)SNC[C@H]1CCS(=O)(=O)C1
|
Cc1nc(-c2ccccn2)sc1C(=O)NC[C@H]1CCS(=O)(=O)C1
|
Cc1nc(-c2ccccn2)sc1CC(=O)SNC[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nc(-c2ccccn2)sc1C(=O)NC[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccccn2)sc1C(=O)CCCC(=O)NC[C@H]1CCS(=O)(=O)C1
|
Cc1nc(-c2ccccn2)sc1C(=O)NC[C@H]1CCS(=O)(=O)C1
|
Cc1nc(-c2ccccn2)sc1C(=O)CCCC(=O)NC[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nc(-c2ccccn2)sc1C(=O)NC[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccccn2)sc1C(C)(C)CC(=O)NC[C@H]1CCS(=O)(=O)C1
|
Cc1nc(-c2ccccn2)sc1C(=O)NC[C@H]1CCS(=O)(=O)C1
|
Cc1nc(-c2ccccn2)sc1C(C)(C)CC(=O)NC[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nc(-c2ccccn2)sc1C(=O)NC[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccccn2)sc1C(C)(C)CCC(=O)NC[C@H]1CCS(=O)(=O)C1
|
Cc1nc(-c2ccccn2)sc1C(=O)NC[C@H]1CCS(=O)(=O)C1
|
Cc1nc(-c2ccccn2)sc1C(C)(C)CCC(=O)NC[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nc(-c2ccccn2)sc1C(=O)NC[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccccn2)sc1[C@H](C)C(=O)SNC[C@H]1CCS(=O)(=O)C1
|
Cc1nc(-c2ccccn2)sc1C(=O)NC[C@H]1CCS(=O)(=O)C1
|
Cc1nc(-c2ccccn2)sc1[C@H](C)C(=O)SNC[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule C=CCC[C@@H](C)[NH+](C)CCc1nccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC[C@@H](C)[NH+]1CCC(CCc2nccs2)CC1
|
C=CCC[C@@H](C)[NH+](C)CCc1nccs1
|
C=CCC[C@@H](C)[NH+]1CCC(CCc2nccs2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC&CC1",
"old_substring": "[NH+]23C"
}
|
Can you make molecule C=CCC[C@@H](C)[NH+](C)CCc1nccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC[C@@H](C)[NH+]1Cc2cc(CCc3nccs3)sc2C1
|
C=CCC[C@@H](C)[NH+](C)CCc1nccs1
|
C=CCC[C@@H](C)[NH+]1Cc2cc(CCc3nccs3)sc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&Cc2cc&sc2C1",
"old_substring": "[NH+]23C"
}
|
Can you make molecule C=CCC[C@@H](C)[NH+](C)CCc1nccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC[C@@H](C)[NH+]1CCc2nc(CCc3nccs3)sc2C1
|
C=CCC[C@@H](C)[NH+](C)CCc1nccs1
|
C=CCC[C@@H](C)[NH+]1CCc2nc(CCc3nccs3)sc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCc2nc&sc2C1",
"old_substring": "[NH+]23C"
}
|
Can you make molecule C=CCC[C@@H](C)[NH+](C)CCc1nccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC[C@@H](C)[NH+]1CCc2sc(CCc3nccs3)cc2C1
|
C=CCC[C@@H](C)[NH+](C)CCc1nccs1
|
C=CCC[C@@H](C)[NH+]1CCc2sc(CCc3nccs3)cc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCc2sc&cc2C1",
"old_substring": "[NH+]23C"
}
|
Can you make molecule C=CCC[C@@H](C)[NH+](C)CCc1nccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC[C@@H](C)C[NH+](C)CCCc1nccs1
|
C=CCC[C@@H](C)[NH+](C)CCc1nccs1
|
C=CCC[C@@H](C)C[NH+](C)CCCc1nccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[NH+](C&)C&",
"old_substring": "[NH+]23C"
}
|
Can you make molecule Cc1ccc(C(=O)NC[C@@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)c(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)NC[C@@H]2N[C@@H](Cc3ccccc3)CS2)c(C)n1
|
Cc1ccc(C(=O)NC[C@@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)c(C)n1
|
Cc1ccc(C(=O)NC[C@@H]2N[C@@H](Cc3ccccc3)CS2)c(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N[C@@H]&CS1",
"old_substring": "[C@@H]17C[C@@H](O)C[NH+]15"
}
|
Can you make molecule Cc1ccc(C(=O)NC[C@@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)c(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)NC[C@@H]2CC[C@@H](Cc3ccccc3)O2)c(C)n1
|
Cc1ccc(C(=O)NC[C@@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)c(C)n1
|
Cc1ccc(C(=O)NC[C@@H]2CC[C@@H](Cc3ccccc3)O2)c(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&O1",
"old_substring": "[C@@H]17C[C@@H](O)C[NH+]15"
}
|
Can you make molecule Cc1ccc(C(=O)NC[C@@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)c(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)NC[C@@H]2C[NH+](Cc3ccccc3)CCS2)c(C)n1
|
Cc1ccc(C(=O)NC[C@@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)c(C)n1
|
Cc1ccc(C(=O)NC[C@@H]2C[NH+](Cc3ccccc3)CCS2)c(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&C[NH+]&CCS1",
"old_substring": "[C@@H]17C[C@@H](O)C[NH+]15"
}
|
Can you make molecule Cc1ccc(C(=O)NC[C@@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)c(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)NC[C@@H]2CC[C@H](Cc3ccccc3)O2)c(C)n1
|
Cc1ccc(C(=O)NC[C@@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)c(C)n1
|
Cc1ccc(C(=O)NC[C@@H]2CC[C@H](Cc3ccccc3)O2)c(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@H]&O1",
"old_substring": "[C@@H]17C[C@@H](O)C[NH+]15"
}
|
Can you make molecule Cc1ccc(C(=O)NC[C@@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)c(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)NC[C@@H]2CCN(CCc3ccccc3)C2)c(C)n1
|
Cc1ccc(C(=O)NC[C@@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)c(C)n1
|
Cc1ccc(C(=O)NC[C@@H]2CCN(CCc3ccccc3)C2)c(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCN(C&)C1",
"old_substring": "[C@@H]17C[C@@H](O)C[NH+]15"
}
|
Can you make molecule Cc1nc(NC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(NSC(=O)Cc2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
|
Cc1nc(NC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
|
Cc1nc(NSC(=O)Cc2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1nc(NC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(NC(=O)CCCC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
|
Cc1nc(NC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
|
Cc1nc(NC(=O)CCCC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1nc(NC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(NC(=O)CC(C)(C)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
|
Cc1nc(NC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
|
Cc1nc(NC(=O)CC(C)(C)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1nc(NC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(NC(=O)CCC(C)(C)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
|
Cc1nc(NC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
|
Cc1nc(NC(=O)CCC(C)(C)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule Cc1nc(NC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(NSC(=O)[C@@H](C)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
|
Cc1nc(NC(=O)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
|
Cc1nc(NSC(=O)[C@@H](C)c2c3c(nn2[C@H]2CCS(=O)(=O)C2)CCC3)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C46=O"
}
|
Can you make molecule COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC
|
COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC
|
COCc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO5"
}
|
Can you make molecule COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC
|
COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC
|
COCSc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO5"
}
|
Can you make molecule COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(SC(C)=O)c1OC
|
COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC
|
COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(SC(C)=O)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO5"
}
|
Can you make molecule COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(C(=O)CS)c1OC
|
COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC
|
COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(C(=O)CS)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO5"
}
|
Can you make molecule COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(C(=O)CI)c1OC
|
COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(OC)c1OC
|
COc1cc([C@H]2CC(=O)n3nc(-c4ccc(C)cc4)nc3S2)cc(C(=O)CI)c1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO5"
}
|
Can you make molecule Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2)cc1C(=O)N(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2Cl)cc1C(=O)N(C)C
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2)cc1C(=O)N(C)C
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2Cl)cc1C(=O)N(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c18ccc(F)cc1"
}
|
Can you make molecule Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2)cc1C(=O)N(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2Br)cc1C(=O)N(C)C
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2)cc1C(=O)N(C)C
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2Br)cc1C(=O)N(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Br",
"old_substring": "c18ccc(F)cc1"
}
|
Can you make molecule Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2)cc1C(=O)N(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)c(Cl)c2)cc1C(=O)N(C)C
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2)cc1C(=O)N(C)C
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)c(Cl)c2)cc1C(=O)N(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)c(Cl)c1",
"old_substring": "c18ccc(F)cc1"
}
|
Can you make molecule Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2)cc1C(=O)N(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(I)cc2F)cc1C(=O)N(C)C
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2)cc1C(=O)N(C)C
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(I)cc2F)cc1C(=O)N(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1F",
"old_substring": "c18ccc(F)cc1"
}
|
Can you make molecule Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2)cc1C(=O)N(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2cc3c(F)cccc3s2)cc1C(=O)N(C)C
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2ccc(F)cc2)cc1C(=O)N(C)C
|
Cc1ccc(NC(=O)c2c[nH]cc2-c2cc3c(F)cccc3s2)cc1C(=O)N(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2c(F)cccc2s1",
"old_substring": "c18ccc(F)cc1"
}
|
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