prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1
|
CCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1
|
C=CSc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC6"
}
|
Can you make molecule CCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1
|
CCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1
|
CC(C)c1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC6"
}
|
Can you make molecule CCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1
|
CCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1
|
C=CCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC6"
}
|
Can you make molecule CCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1Cc2cc(NS(=O)(=O)c3ccc(CCCCl)s3)ccc2N1
|
CCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1
|
O=C1Cc2cc(NS(=O)(=O)c3ccc(CCCCl)s3)ccc2N1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC6"
}
|
Can you make molecule CCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1Cc2cc(NS(=O)(=O)c3ccc(CCCCS)s3)ccc2N1
|
CCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CC(=O)N3)s1
|
O=C1Cc2cc(NS(=O)(=O)c3ccc(CCCCS)s3)ccc2N1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC6"
}
|
Can you make molecule CC[C@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](CBr)C[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
|
CC[C@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
|
CC[C@H](CBr)C[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](C&)CBr",
"old_substring": "CC[C@@H]3C"
}
|
Can you make molecule CC[C@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](CCCl)C[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
|
CC[C@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
|
CC[C@H](CCCl)C[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](C&)CCCl",
"old_substring": "CC[C@@H]3C"
}
|
Can you make molecule CC[C@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cl)CCC[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
|
CC[C@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
|
CC[C@@H](Cl)CCC[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](Cl)CCC&",
"old_substring": "CC[C@@H]3C"
}
|
Can you make molecule CC[C@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](Cl)[C@@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
|
CC[C@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
|
CC[C@@H](Cl)[C@@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@@H](Cl)[C@H]&C",
"old_substring": "CC[C@@H]3C"
}
|
Can you make molecule CC[C@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CBr)C[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
|
CC[C@H](C)[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
|
CC[C@@H](CBr)C[NH+]1CCN(C[C@H]2CCCC(C)(C)C2=O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H](C&)CBr",
"old_substring": "CC[C@@H]3C"
}
|
Can you make molecule O=C(NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O)Nc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C2=CC=CC2=C(NC[C@H]2CCCCN2C(=O)c2cc(Cl)ccc2O)CCN1Nc1ccccc1
|
O=C(NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O)Nc1ccccc1
|
O=C1C2=CC=CC2=C(NC[C@H]2CCCCN2C(=O)c2cc(Cl)ccc2O)CCN1Nc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1c2cccc&c2CCN1&",
"old_substring": "O=C23"
}
|
Can you make molecule O=C(NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O)Nc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1c(NC[C@H]2CCCCN2C(=O)c2cc(Cl)ccc2O)cc(Nc2ccccc2)ccc2oc1-2
|
O=C(NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O)Nc1ccccc1
|
O=Cc1c(NC[C@H]2CCCCN2C(=O)c2cc(Cl)ccc2O)cc(Nc2ccccc2)ccc2oc1-2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1c&oc2ccc&cc12",
"old_substring": "O=C23"
}
|
Can you make molecule O=C(NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O)Nc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/SNc1ccccc1)NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O
|
O=C(NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O)Nc1ccccc1
|
O=C(/C=C/SNc1ccccc1)NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C23"
}
|
Can you make molecule O=C(NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O)Nc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C(=NC[C@H]2CCCCN2C(=O)c2cc(Cl)ccc2O)CCC1=Nc1ccccc1
|
O=C(NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O)Nc1ccccc1
|
O=C1C(=NC[C@H]2CCCCN2C(=O)c2cc(Cl)ccc2O)CCC1=Nc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1C=&CCC1=&",
"old_substring": "O=C23"
}
|
Can you make molecule O=C(NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O)Nc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1cc(Cl)ccc1O)N1CCCC[C@@H]1CNO/N=C/c1ccc(Nc2ccccc2)o1
|
O=C(NC[C@H]1CCCCN1C(=O)c1cc(Cl)ccc1O)Nc1ccccc1
|
O=C(c1cc(Cl)ccc1O)N1CCCC[C@@H]1CNO/N=C/c1ccc(Nc2ccccc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C23"
}
|
Can you make molecule CC[NH2+][C@H](Cc1ncnn1C)C1([NH+]2CCCC2)CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH2+][C@H]1CC[C@@](c2ncnn2C)(C2([NH+]3CCCC3)CCCC2)C1
|
CC[NH2+][C@H](Cc1ncnn1C)C1([NH+]2CCCC2)CCCC1
|
CC[NH2+][C@H]1CC[C@@](c2ncnn2C)(C2([NH+]3CCCC3)CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@]&&C1",
"old_substring": "[C@H]47C6"
}
|
Can you make molecule CC[NH2+][C@H](Cc1ncnn1C)C1([NH+]2CCCC2)CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH2+][C@H]1CC[C@](c2ncnn2C)(C2([NH+]3CCCC3)CCCC2)C1
|
CC[NH2+][C@H](Cc1ncnn1C)C1([NH+]2CCCC2)CCCC1
|
CC[NH2+][C@H]1CC[C@](c2ncnn2C)(C2([NH+]3CCCC3)CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@@]&&C1",
"old_substring": "[C@H]47C6"
}
|
Can you make molecule CC[NH2+][C@H](Cc1ncnn1C)C1([NH+]2CCCC2)CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH2+][C@@H](CCCC1([NH+]2CCCC2)CCCC1)C(C)(C)c1ncnn1C
|
CC[NH2+][C@H](Cc1ncnn1C)C1([NH+]2CCCC2)CCCC1
|
CC[NH2+][C@@H](CCCC1([NH+]2CCCC2)CCCC1)C(C)(C)c1ncnn1C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CCC&)C&(C)C",
"old_substring": "[C@H]47C6"
}
|
Can you make molecule CC[NH2+][C@H](Cc1ncnn1C)C1([NH+]2CCCC2)CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH2+][C@@H]1CCC[C@@](c2ncnn2C)(C2([NH+]3CCCC3)CCCC2)C1
|
CC[NH2+][C@H](Cc1ncnn1C)C1([NH+]2CCCC2)CCCC1
|
CC[NH2+][C@@H]1CCC[C@@](c2ncnn2C)(C2([NH+]3CCCC3)CCCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCC[C@]&&C1",
"old_substring": "[C@H]47C6"
}
|
Can you make molecule CC[NH2+][C@H](Cc1ncnn1C)C1([NH+]2CCCC2)CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH2+]CC[C@H](CC1([NH+]2CCCC2)CCCC1)C(=O)c1ncnn1C
|
CC[NH2+][C@H](Cc1ncnn1C)C1([NH+]2CCCC2)CCCC1
|
CC[NH2+]CC[C@H](CC1([NH+]2CCCC2)CCCC1)C(=O)c1ncnn1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C[C@H](C&)C&=O",
"old_substring": "[C@H]47C6"
}
|
Can you make molecule CCOc1ccc(C=C2SC(=S)N(Cc3ccco3)C2=O)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(C=C2CCCC(=Cc3ccco3)C2=O)cc1OC
|
CCOc1ccc(C=C2SC(=S)N(Cc3ccco3)C2=O)cc1OC
|
CCOc1ccc(C=C2CCCC(=Cc3ccco3)C2=O)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCCC=&C1=O",
"old_substring": "C1=7SC(=S)N8C1=O"
}
|
Can you make molecule CCOc1ccc(C=C2SC(=S)N(Cc3ccco3)C2=O)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(C=CC2=CN=N[C@H]2Cc2ccco2)cc1OC
|
CCOc1ccc(C=C2SC(=S)N(Cc3ccco3)C2=O)cc1OC
|
CCOc1ccc(C=CC2=CN=N[C@H]2Cc2ccco2)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(C&)[C@H]&N=N1",
"old_substring": "C1=7SC(=S)N8C1=O"
}
|
Can you make molecule CCOc1ccc(C=C2SC(=S)N(Cc3ccco3)C2=O)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(C=C2CC(F)(Cc3ccco3)C2)cc1OC
|
CCOc1ccc(C=C2SC(=S)N(Cc3ccco3)C2=O)cc1OC
|
CCOc1ccc(C=C2CC(F)(Cc3ccco3)C2)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&(F)C1",
"old_substring": "C1=7SC(=S)N8C1=O"
}
|
Can you make molecule CCOc1ccc(C=C2SC(=S)N(Cc3ccco3)C2=O)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(C=C2CC(C#N)(Cc3ccco3)C2)cc1OC
|
CCOc1ccc(C=C2SC(=S)N(Cc3ccco3)C2=O)cc1OC
|
CCOc1ccc(C=C2CC(C#N)(Cc3ccco3)C2)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&(C#N)C1",
"old_substring": "C1=7SC(=S)N8C1=O"
}
|
Can you make molecule CCOc1ccc(C=C2SC(=S)N(Cc3ccco3)C2=O)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccc(C=CC2=CN=N[C@@H]2Cc2ccco2)cc1OC
|
CCOc1ccc(C=C2SC(=S)N(Cc3ccco3)C2=O)cc1OC
|
CCOc1ccc(C=CC2=CN=N[C@@H]2Cc2ccco2)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(C&)[C@@H]&N=N1",
"old_substring": "C1=7SC(=S)N8C1=O"
}
|
Can you make molecule O=c1n(CCSc2nnnn2-c2ccc(OC(F)(F)F)cc2)nc2ccccn12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1n(CCSc2nnnn2-c2ccc(CC(F)(F)F)cc2)nc2ccccn12
|
O=c1n(CCSc2nnnn2-c2ccc(OC(F)(F)F)cc2)nc2ccccn12
|
O=c1n(CCSc2nnnn2-c2ccc(CC(F)(F)F)cc2)nc2ccccn12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)F",
"old_substring": "O3C(F)(F)F"
}
|
Can you make molecule O=c1n(CCSc2nnnn2-c2ccc(OC(F)(F)F)cc2)nc2ccccn12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1n(CCSc2nnnn2-c2ccc(SC(F)(F)F)cc2)nc2ccccn12
|
O=c1n(CCSc2nnnn2-c2ccc(OC(F)(F)F)cc2)nc2ccccn12
|
O=c1n(CCSc2nnnn2-c2ccc(SC(F)(F)F)cc2)nc2ccccn12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "O3C(F)(F)F"
}
|
Can you make molecule O=c1n(CCSc2nnnn2-c2ccc(OC(F)(F)F)cc2)nc2ccccn12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1n(CCSc2nnnn2-c2ccc([C@@H](O)CCC(F)(F)F)cc2)nc2ccccn12
|
O=c1n(CCSc2nnnn2-c2ccc(OC(F)(F)F)cc2)nc2ccccn12
|
O=c1n(CCSc2nnnn2-c2ccc([C@@H](O)CCC(F)(F)F)cc2)nc2ccccn12
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@H]&CCC(F)(F)F",
"old_substring": "O3C(F)(F)F"
}
|
Can you make molecule O=c1n(CCSc2nnnn2-c2ccc(OC(F)(F)F)cc2)nc2ccccn12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1n(CCSc2nnnn2-c2ccc(CCCC(F)(F)F)cc2)nc2ccccn12
|
O=c1n(CCSc2nnnn2-c2ccc(OC(F)(F)F)cc2)nc2ccccn12
|
O=c1n(CCSc2nnnn2-c2ccc(CCCC(F)(F)F)cc2)nc2ccccn12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "O3C(F)(F)F"
}
|
Can you make molecule O=c1n(CCSc2nnnn2-c2ccc(OC(F)(F)F)cc2)nc2ccccn12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(c1ccc(-n2nnnc2SCCn2nc3ccccn3c2=O)cc1)C(F)(F)C(F)(F)F
|
O=c1n(CCSc2nnnn2-c2ccc(OC(F)(F)F)cc2)nc2ccccn12
|
O=C(c1ccc(-n2nnnc2SCCn2nc3ccccn3c2=O)cc1)C(F)(F)C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&C(F)(F)C(F)(F)F",
"old_substring": "O3C(F)(F)F"
}
|
Can you make molecule O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cccnc2)on1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2ccccc2)on1
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cccnc2)on1
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2ccccc2)on1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1",
"old_substring": "c17cccnc1"
}
|
Can you make molecule O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cccnc2)on1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2ccc(I)nc2)on1
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cccnc2)on1
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2ccc(I)nc2)on1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)nc1",
"old_substring": "c17cccnc1"
}
|
Can you make molecule O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cccnc2)on1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cc3cnsc3s2)on1
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cccnc2)on1
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cc3cnsc3s2)on1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cnsc2s1",
"old_substring": "c17cccnc1"
}
|
Can you make molecule O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cccnc2)on1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2cc(C(=O)Nc3ccc(N4CCOCC4)cn3)no2)c(C)n1
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cccnc2)on1
|
Cc1ccc(-c2cc(C(=O)Nc3ccc(N4CCOCC4)cn3)no2)c(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(C)nc1C",
"old_substring": "c17cccnc1"
}
|
Can you make molecule O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cccnc2)on1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2ccncc2Cl)on1
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2cccnc2)on1
|
O=C(Nc1ccc(N2CCOCC2)cn1)c1cc(-c2ccncc2Cl)on1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccncc1Cl",
"old_substring": "c17cccnc1"
}
|
Can you make molecule CCc1c(CBr)cnn1-c1ccc(OC)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(C(Br)Br)cnn1-c1ccc(OC)cc1
|
CCc1c(CBr)cnn1-c1ccc(OC)cc1
|
CCc1c(C(Br)Br)cnn1-c1ccc(OC)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(Br)Br",
"old_substring": "C4Br"
}
|
Can you make molecule CCc1c(CBr)cnn1-c1ccc(OC)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(-c2oc(Br)cc2C)cnn1-c1ccc(OC)cc1
|
CCc1c(CBr)cnn1-c1ccc(OC)cc1
|
CCc1c(-c2oc(Br)cc2C)cnn1-c1ccc(OC)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(Br)oc1&",
"old_substring": "C4Br"
}
|
Can you make molecule CCc1c(CBr)cnn1-c1ccc(OC)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(-c2sc(C)cc2Br)cnn1-c1ccc(OC)cc1
|
CCc1c(CBr)cnn1-c1ccc(OC)cc1
|
CCc1c(-c2sc(C)cc2Br)cnn1-c1ccc(OC)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(Br)c&s1",
"old_substring": "C4Br"
}
|
Can you make molecule CCc1c(CBr)cnn1-c1ccc(OC)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(-c2cc(Br)sc2C)cnn1-c1ccc(OC)cc1
|
CCc1c(CBr)cnn1-c1ccc(OC)cc1
|
CCc1c(-c2cc(Br)sc2C)cnn1-c1ccc(OC)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1sc(Br)cc1&",
"old_substring": "C4Br"
}
|
Can you make molecule CCc1c(CBr)cnn1-c1ccc(OC)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1c(CC(Br)(CC)CC)cnn1-c1ccc(OC)cc1
|
CCc1c(CBr)cnn1-c1ccc(OC)cc1
|
CCc1c(CC(Br)(CC)CC)cnn1-c1ccc(OC)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(Br)(C&)CC",
"old_substring": "C4Br"
}
|
Can you make molecule COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCCCCCC2)cc1
|
COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCC2)cc1
|
COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCCCCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCCCCCCC1",
"old_substring": "C16CCCCCCC1"
}
|
Can you make molecule COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)N=C(C)C2CCC(C)CC2)cc1
|
COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCC2)cc1
|
COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)N=C(C)C2CCC(C)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&C1CCC(C)CC1",
"old_substring": "C16CCCCCCC1"
}
|
Can you make molecule COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)N=CC2=C(C)CCCC2(C)C)cc1
|
COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCC2)cc1
|
COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)N=CC2=C(C)CCCC2(C)C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&C1=C(C)CCCC1(C)C",
"old_substring": "C16CCCCCCC1"
}
|
Can you make molecule COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(CBr)(CCC)CNC(=O)[C@@]1(C)Cc2ccccc2C(=O)N1Cc1ccc(OC)cc1
|
COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCC2)cc1
|
CCCC(CBr)(CCC)CNC(=O)[C@@]1(C)Cc2ccccc2C(=O)N1Cc1ccc(OC)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC(C&)(CBr)CCC",
"old_substring": "C16CCCCCCC1"
}
|
Can you make molecule COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](C=NC(=O)[C@@]1(C)Cc2ccccc2C(=O)N1Cc1ccc(OC)cc1)CC
|
COc1ccc(CN2C(=O)c3ccccc3C[C@]2(C)C(=O)NC2CCCCCCC2)cc1
|
CCCC[C@@H](C=NC(=O)[C@@]1(C)Cc2ccccc2C(=O)N1Cc1ccc(OC)cc1)CC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@@H](C=&)CC",
"old_substring": "C16CCCCCCC1"
}
|
Can you make molecule COCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21
|
COCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21
|
COCCCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C5C7"
}
|
Can you make molecule COCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21
|
COCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21
|
COCCCCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C5C7"
}
|
Can you make molecule COCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1CC(n2c(C(=O)N3CCO[C@@H](c4ccccc4)C3)cc3cc(Cl)ccc32)C1
|
COCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21
|
COC1CC(n2c(C(=O)N3CCO[C@@H](c4ccccc4)C3)cc3cc(Cl)ccc32)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C5C7"
}
|
Can you make molecule COCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@@H](C)CCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21
|
COCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21
|
CO[C@@H](C)CCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C5C7"
}
|
Can you make molecule COCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1CCC(n2c(C(=O)N3CCO[C@@H](c4ccccc4)C3)cc3cc(Cl)ccc32)CC1
|
COCCn1c(C(=O)N2CCO[C@@H](c3ccccc3)C2)cc2cc(Cl)ccc21
|
COC1CCC(n2c(C(=O)N3CCO[C@@H](c4ccccc4)C3)cc3cc(Cl)ccc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C5C7"
}
|
Can you make molecule CCOCCCC(=O)N1CCN(CCO)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSOCCCC(=O)N1CCN(CCO)CC1
|
CCOCCCC(=O)N1CCN(CCO)CC1
|
C=CSOCCCC(=O)N1CCN(CCO)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC3"
}
|
Can you make molecule CCOCCCC(=O)N1CCN(CCO)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCOCCCC(=O)N1CCN(CCO)CC1
|
CCOCCCC(=O)N1CCN(CCO)CC1
|
C=CCCOCCCC(=O)N1CCN(CCO)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CCOCCCC(=O)N1CCN(CCO)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCOCCCCl)N1CCN(CCO)CC1
|
CCOCCCC(=O)N1CCN(CCO)CC1
|
O=C(CCCOCCCCl)N1CCN(CCO)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CCOCCCC(=O)N1CCN(CCO)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCOCCCCS)N1CCN(CCO)CC1
|
CCOCCCC(=O)N1CCN(CCO)CC1
|
O=C(CCCOCCCCS)N1CCN(CCO)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule CCOCCCC(=O)N1CCN(CCO)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCOCCCBr)N1CCN(CCO)CC1
|
CCOCCCC(=O)N1CCN(CCO)CC1
|
O=C(CCCOCCCBr)N1CCN(CCO)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC3"
}
|
Can you make molecule [O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCOCC3)n1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCCC3)n1)C2
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCOCC3)n1)C2
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCCC3)n1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule [O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCOCC3)n1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCCCC3)n1)C2
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCOCC3)n1)C2
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCCCC3)n1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule [O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCOCC3)n1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCSCC3)n1)C2
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCOCC3)n1)C2
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCSCC3)n1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSCC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule [O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCOCC3)n1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CC=CC3)n1)C2
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCOCC3)n1)C2
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CC=CC3)n1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC=CC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule [O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCOCC3)n1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(SSN3CCOCC3)n1)C2
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(N3CCOCC3)n1)C2
|
[O-]c1nc(-c2cccnc2)nc2c1CC[NH+](Cc1ccnc(SSN3CCOCC3)n1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SN1CCOCC1",
"old_substring": "N15CCOCC1"
}
|
Can you make molecule O=C([O-])[C@H](Cc1ccccc1)NC(=O)N(c1ccccc1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])[C@H](Cc1ccccc1Cl)NC(=O)N(c1ccccc1)c1ccccc1
|
O=C([O-])[C@H](Cc1ccccc1)NC(=O)N(c1ccccc1)c1ccccc1
|
O=C([O-])[C@H](Cc1ccccc1Cl)NC(=O)N(c1ccccc1)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c17ccccc1"
}
|
Can you make molecule O=C([O-])[C@H](Cc1ccccc1)NC(=O)N(c1ccccc1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])[C@H](Cc1ccc(I)cc1)NC(=O)N(c1ccccc1)c1ccccc1
|
O=C([O-])[C@H](Cc1ccccc1)NC(=O)N(c1ccccc1)c1ccccc1
|
O=C([O-])[C@H](Cc1ccc(I)cc1)NC(=O)N(c1ccccc1)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule O=C([O-])[C@H](Cc1ccccc1)NC(=O)N(c1ccccc1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C[C@H](NC(=O)N(c2ccccc2)c2ccccc2)C(=O)[O-])cc1I
|
O=C([O-])[C@H](Cc1ccccc1)NC(=O)N(c1ccccc1)c1ccccc1
|
Cc1ccc(C[C@H](NC(=O)N(c2ccccc2)c2ccccc2)C(=O)[O-])cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c17ccccc1"
}
|
Can you make molecule O=C([O-])[C@H](Cc1ccccc1)NC(=O)N(c1ccccc1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])[C@H](Cc1cccc(Br)c1)NC(=O)N(c1ccccc1)c1ccccc1
|
O=C([O-])[C@H](Cc1ccccc1)NC(=O)N(c1ccccc1)c1ccccc1
|
O=C([O-])[C@H](Cc1cccc(Br)c1)NC(=O)N(c1ccccc1)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule O=C([O-])[C@H](Cc1ccccc1)NC(=O)N(c1ccccc1)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C[C@H](NC(=O)N(c2ccccc2)c2ccccc2)C(=O)[O-])c1C
|
O=C([O-])[C@H](Cc1ccccc1)NC(=O)N(c1ccccc1)c1ccccc1
|
Cc1cccc(C[C@H](NC(=O)N(c2ccccc2)c2ccccc2)C(=O)[O-])c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CCCC[C@@H](C)NC(=O)[C@H]1CCC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](C)NSC(=O)C[C@H]1CCC[NH2+][C@@H]1C
|
CCCC[C@@H](C)NC(=O)[C@H]1CCC[NH2+][C@@H]1C
|
CCCC[C@@H](C)NSC(=O)C[C@H]1CCC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule CCCC[C@@H](C)NC(=O)[C@H]1CCC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](C)NCC(=C=O)C[C@H]1CCC[NH2+][C@@H]1C
|
CCCC[C@@H](C)NC(=O)[C@H]1CCC[NH2+][C@@H]1C
|
CCCC[C@@H](C)NCC(=C=O)C[C@H]1CCC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule CCCC[C@@H](C)NC(=O)[C@H]1CCC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](C)NC(=O)CCCC(=O)[C@H]1CCC[NH2+][C@@H]1C
|
CCCC[C@@H](C)NC(=O)[C@H]1CCC[NH2+][C@@H]1C
|
CCCC[C@@H](C)NC(=O)CCCC(=O)[C@H]1CCC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C24=O"
}
|
Can you make molecule CCCC[C@@H](C)NC(=O)[C@H]1CCC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](C)NC(=O)CC(C)(C)[C@H]1CCC[NH2+][C@@H]1C
|
CCCC[C@@H](C)NC(=O)[C@H]1CCC[NH2+][C@@H]1C
|
CCCC[C@@H](C)NC(=O)CC(C)(C)[C@H]1CCC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule CCCC[C@@H](C)NC(=O)[C@H]1CCC[NH2+][C@@H]1C less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](C)NC[S@+]([O-])CCC[C@H]1CCC[NH2+][C@@H]1C
|
CCCC[C@@H](C)NC(=O)[C@H]1CCC[NH2+][C@@H]1C
|
CCCC[C@@H](C)NC[S@+]([O-])CCC[C@H]1CCC[NH2+][C@@H]1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C24=O"
}
|
Can you make molecule C[C@H](Cc1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(C)(C)c1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1
|
C[C@H](Cc1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1
|
C[C@H](CC(C)(C)c1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@@H]3C5"
}
|
Can you make molecule C[C@H](Cc1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCN(C)C(=O)CCSc1ccc(C#N)cc1)CC(=O)c1ccc(O)cc1
|
C[C@H](Cc1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1
|
C[C@@H](CCN(C)C(=O)CCSc1ccc(C#N)cc1)CC(=O)c1ccc(O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@@H]3C5"
}
|
Can you make molecule C[C@H](Cc1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CCN(C)C(=O)CCSc1ccc(C#N)cc1)CC(=O)c1ccc(O)cc1
|
C[C@H](Cc1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1
|
C[C@H](CCN(C)C(=O)CCSc1ccc(C#N)cc1)CC(=O)c1ccc(O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "C[C@@H]3C5"
}
|
Can you make molecule C[C@H](Cc1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C[C@@H](Cl)CCc1ccc(O)cc1)C(=O)CCSc1ccc(C#N)cc1
|
C[C@H](Cc1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1
|
CN(C[C@@H](Cl)CCc1ccc(O)cc1)C(=O)CCSc1ccc(C#N)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cl[C@H](C&)CC&",
"old_substring": "C[C@@H]3C5"
}
|
Can you make molecule C[C@H](Cc1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)CCSc1ccc(C#N)cc1)[C@]1(C)O[C@@H](c2ccc(O)cc2)CS1
|
C[C@H](Cc1ccc(O)cc1)N(C)C(=O)CCSc1ccc(C#N)cc1
|
CN(C(=O)CCSc1ccc(C#N)cc1)[C@]1(C)O[C@@H](c2ccc(O)cc2)CS1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@]1&O[C@@H]&CS1",
"old_substring": "C[C@@H]3C5"
}
|
Can you make molecule O=C(Cl)COc1ccc2c(c1)CCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cl)CCCOc1ccc2c(c1)CCC2
|
O=C(Cl)COc1ccc2c(c1)CCC2
|
O=C(Cl)CCCOc1ccc2c(c1)CCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(Cl)CCC&",
"old_substring": "O=C(Cl)C3"
}
|
Can you make molecule O=C(Cl)COc1ccc2c(c1)CCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cl)[C@H](Cl)Oc1ccc2c(c1)CCC2
|
O=C(Cl)COc1ccc2c(c1)CCC2
|
O=C(Cl)[C@H](Cl)Oc1ccc2c(c1)CCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(Cl)[C@@H]&Cl",
"old_substring": "O=C(Cl)C3"
}
|
Can you make molecule O=C(Cl)COc1ccc2c(c1)CCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cl)Oc1ccc2c(c1)CCC2
|
O=C(Cl)COc1ccc2c(c1)CCC2
|
O=C(Cl)Oc1ccc2c(c1)CCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&Cl",
"old_substring": "O=C(Cl)C3"
}
|
Can you make molecule O=C(Cl)COc1ccc2c(c1)CCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1c(Cl)nc(Cl)n1Oc1ccc2c(c1)CCC2
|
O=C(Cl)COc1ccc2c(c1)CCC2
|
O=Cc1c(Cl)nc(Cl)n1Oc1ccc2c(c1)CCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1c(Cl)nc(Cl)n1&",
"old_substring": "O=C(Cl)C3"
}
|
Can you make molecule O=C(Cl)COc1ccc2c(c1)CCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1ccc(Oc2ccc3c(c2)CCC3)c(Cl)c1
|
O=C(Cl)COc1ccc2c(c1)CCC2
|
O=Cc1ccc(Oc2ccc3c(c2)CCC3)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1ccc&c(Cl)c1",
"old_substring": "O=C(Cl)C3"
}
|
Can you make molecule CCC[C@@H](COC)Nc1ccc(C#N)c(N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](C[C@@H](C)[PH2]=O)Nc1ccc(C#N)c(N)c1
|
CCC[C@@H](COC)Nc1ccc(C#N)c(N)c1
|
CCC[C@@H](C[C@@H](C)[PH2]=O)Nc1ccc(C#N)c(N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=[PH2][C@@H]2C&",
"old_substring": "O2C"
}
|
Can you make molecule CCC[C@@H](COC)Nc1ccc(C#N)c(N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CSCOC)Nc1ccc(C#N)c(N)c1
|
CCC[C@@H](COC)Nc1ccc(C#N)c(N)c1
|
CCC[C@@H](CSCOC)Nc1ccc(C#N)c(N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "O2C"
}
|
Can you make molecule CCC[C@@H](COC)Nc1ccc(C#N)c(N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](COCCl)Nc1ccc(C#N)c(N)c1
|
CCC[C@@H](COC)Nc1ccc(C#N)c(N)c1
|
CCC[C@@H](COCCl)Nc1ccc(C#N)c(N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&CCl",
"old_substring": "O2C"
}
|
Can you make molecule CCC[C@@H](COC)Nc1ccc(C#N)c(N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CC(=O)Cl)Nc1ccc(C#N)c(N)c1
|
CCC[C@@H](COC)Nc1ccc(C#N)c(N)c1
|
CCC[C@@H](CC(=O)Cl)Nc1ccc(C#N)c(N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&Cl",
"old_substring": "O2C"
}
|
Can you make molecule CCC[C@@H](COC)Nc1ccc(C#N)c(N)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](C=C(Br)C=O)Nc1ccc(C#N)c(N)c1
|
CCC[C@@H](COC)Nc1ccc(C#N)c(N)c1
|
CCC[C@@H](C=C(Br)C=O)Nc1ccc(C#N)c(N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=CC=&Br",
"old_substring": "O2C"
}
|
Can you make molecule CC(=O)NCCNC(=O)CSC1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCNSC(=O)CSC1CCCC1
|
CC(=O)NCCNC(=O)CSC1CCCC1
|
CC(=O)NCCNSC(=O)CSC1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C3(=O)C6"
}
|
Can you make molecule CC(=O)NCCNC(=O)CSC1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCNC(=O)CCCC(=O)SC1CCCC1
|
CC(=O)NCCNC(=O)CSC1CCCC1
|
CC(=O)NCCNC(=O)CCCC(=O)SC1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C3(=O)C6"
}
|
Can you make molecule CC(=O)NCCNC(=O)CSC1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCNC(=O)CC(C)(C)SC1CCCC1
|
CC(=O)NCCNC(=O)CSC1CCCC1
|
CC(=O)NCCNC(=O)CC(C)(C)SC1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C3(=O)C6"
}
|
Can you make molecule CC(=O)NCCNC(=O)CSC1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCNC[S@+]([O-])CCCSC1CCCC1
|
CC(=O)NCCNC(=O)CSC1CCCC1
|
CC(=O)NCCNC[S@+]([O-])CCCSC1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C3(=O)C6"
}
|
Can you make molecule CC(=O)NCCNC(=O)CSC1CCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)NCCNC(=O)CCC(C)(C)SC1CCCC1
|
CC(=O)NCCNC(=O)CSC1CCCC1
|
CC(=O)NCCNC(=O)CCC(C)(C)SC1CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C3(=O)C6"
}
|
Can you make molecule C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)nn1C less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1ccc(CC(C)(C)C)n1C
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)nn1C
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1ccc(CC(C)(C)C)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&n1C",
"old_substring": "c15cc6nn1C"
}
|
Can you make molecule C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)nn1C less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1c(Br)c(CC(C)(C)C)nn1C
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)nn1C
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1c(Br)c(CC(C)(C)C)nn1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(Br)c&nn1C",
"old_substring": "c15cc6nn1C"
}
|
Can you make molecule C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)nn1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CC(C)(C)C)ccc1NC(=O)C(=O)N[C@@H](C)Cc1ccccc1F
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)nn1C
|
Cc1nc(CC(C)(C)C)ccc1NC(=O)C(=O)N[C@@H](C)Cc1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&nc1C",
"old_substring": "c15cc6nn1C"
}
|
Can you make molecule C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)nn1C less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc2ncc(CC(C)(C)C)cc2n1C
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)nn1C
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc2ncc(CC(C)(C)C)cc2n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2ncc&cc2n1C",
"old_substring": "c15cc6nn1C"
}
|
Can you make molecule C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)nn1C less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)cnc1Cl
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)nn1C
|
C[C@@H](Cc1ccccc1F)NC(=O)C(=O)Nc1cc(CC(C)(C)C)cnc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&cnc1Cl",
"old_substring": "c15cc6nn1C"
}
|
Can you make molecule CCn1cc(C(=O)Nc2ccc(CC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cc(C(=O)Nc2ccc(CCC(CO)=NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
|
CCn1cc(C(=O)Nc2ccc(CC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
|
CCn1cc(C(=O)Nc2ccc(CCC(CO)=NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C9C4=O"
}
|
Can you make molecule CCn1cc(C(=O)Nc2ccc(CC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cc(C(=O)Nc2ccc(C/C(C)=N\ONCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
|
CCn1cc(C(=O)Nc2ccc(CC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
|
CCn1cc(C(=O)Nc2ccc(C/C(C)=N\ONCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C9C4=O"
}
|
Can you make molecule CCn1cc(C(=O)Nc2ccc(CC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cc(C(=O)Nc2ccc(C(CC)(CC)C(=O)CNCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
|
CCn1cc(C(=O)Nc2ccc(CC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
|
CCn1cc(C(=O)Nc2ccc(C(CC)(CC)C(=O)CNCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C9C4=O"
}
|
Can you make molecule CCn1cc(C(=O)Nc2ccc(CC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cc(C(=O)Nc2ccc(SSC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
|
CCn1cc(C(=O)Nc2ccc(CC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
|
CCn1cc(C(=O)Nc2ccc(SSC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C9C4=O"
}
|
Can you make molecule CCn1cc(C(=O)Nc2ccc(CC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1cc(C(=O)Nc2ccc(C(CC)(CC)C(=O)CCNCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
|
CCn1cc(C(=O)Nc2ccc(CC(=O)NCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
|
CCn1cc(C(=O)Nc2ccc(C(CC)(CC)C(=O)CCNCC(F)(F)F)cc2)c(=O)c2ccc(C)nc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C9C4=O"
}
|
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