prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sc1c[nH]c2ccccc12)Nc1ccccc1O
|
O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1O
|
O=C(/C=C/Sc1c[nH]c2ccccc12)Nc1ccccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C3CC5"
}
|
Can you make molecule O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(c2c[nH]c3ccccc23)CC1)Nc1ccccc1O
|
O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1O
|
O=C(NN=C1CCC(c2c[nH]c3ccccc23)CC1)Nc1ccccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C3CC5"
}
|
Can you make molecule O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccccc1O)C1=CC[C@H](c2c[nH]c3ccccc23)S1
|
O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1O
|
O=C(Nc1ccccc1O)C1=CC[C@H](c2c[nH]c3ccccc23)S1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&C1=CC[C@H]&S1",
"old_substring": "O=C3CC5"
}
|
Can you make molecule O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\ONc1ccccc1O)[C@H](C)c1c[nH]c2ccccc12
|
O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1O
|
C/C(=N\ONc1ccccc1O)[C@H](C)c1c[nH]c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)[C@@H]&C",
"old_substring": "O=C3CC5"
}
|
Can you make molecule O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1O less soluble in water? The output molecule should be similar to the input molecule.
|
[O-][S@+](CNc1ccccc1O)C(Cl)(Cl)c1c[nH]c2ccccc12
|
O=C(CCc1c[nH]c2ccccc12)Nc1ccccc1O
|
[O-][S@+](CNc1ccccc1O)C(Cl)(Cl)c1c[nH]c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=[S@](C&)C&(Cl)Cl",
"old_substring": "O=C3CC5"
}
|
Can you make molecule COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)cc1I
|
COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1
|
COc1ccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c15cccc8c1"
}
|
Can you make molecule COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)ccc1Br
|
COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1
|
COc1cc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c15cccc8c1"
}
|
Can you make molecule COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)cc1Cl
|
COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1
|
COc1ccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c15cccc8c1"
}
|
Can you make molecule COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1Br
|
COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1
|
COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c15cccc8c1"
}
|
Can you make molecule COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1Cl
|
COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1
|
COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c15cccc8c1"
}
|
Can you make molecule COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCOc1ncccc1NC(=O)CC(C)(C)N(C)Cc1ccccn1
|
COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1
|
COCCOc1ncccc1NC(=O)CC(C)(C)N(C)Cc1ccccn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCOc1ncccc1NC(=O)CCC(C)(C)N(C)Cc1ccccn1
|
COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1
|
COCCOc1ncccc1NC(=O)CCC(C)(C)N(C)Cc1ccccn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCOc1ncccc1NC(=O)C[C@@H](Br)N(C)Cc1ccccn1
|
COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1
|
COCCOc1ncccc1NC(=O)C[C@@H](Br)N(C)Cc1ccccn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCOc1ncccc1Nc1cc(C)n(N(C)Cc2ccccn2)c(=O)c1
|
COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1
|
COCCOc1ncccc1Nc1cc(C)n(N(C)Cc2ccccn2)c(=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C23=O"
}
|
Can you make molecule COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCOc1ncccc1Nc1c(C)n(N(C)Cc2ccccn2)ccc1=O
|
COCCOc1ncccc1NC(=O)N(C)Cc1ccccn1
|
COCCOc1ncccc1Nc1c(C)n(N(C)Cc2ccccn2)ccc1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C23=O"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)F)cc(-c4ccco4)nc23)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C(=O)c2cnn3c(SC(F)(F)F)cc(-c4ccco4)nc23)C1
|
C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)F)cc(-c4ccco4)nc23)C1
|
C[C@H]1CCCN(C(=O)c2cnn3c(SC(F)(F)F)cc(-c4ccco4)nc23)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C7(F)(F)F"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)F)cc(-c4ccco4)nc23)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C(=O)c2cnn3c(CCCC(F)(F)F)cc(-c4ccco4)nc23)C1
|
C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)F)cc(-c4ccco4)nc23)C1
|
C[C@H]1CCCN(C(=O)c2cnn3c(CCCC(F)(F)F)cc(-c4ccco4)nc23)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C7(F)(F)F"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)F)cc(-c4ccco4)nc23)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C(=O)c2cnn3c(CCCCC(F)(F)F)cc(-c4ccco4)nc23)C1
|
C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)F)cc(-c4ccco4)nc23)C1
|
C[C@H]1CCCN(C(=O)c2cnn3c(CCCCC(F)(F)F)cc(-c4ccco4)nc23)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C7(F)(F)F"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)F)cc(-c4ccco4)nc23)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)C(F)(F)F)cc(-c4ccco4)nc23)C1
|
C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)F)cc(-c4ccco4)nc23)C1
|
C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)C(F)(F)F)cc(-c4ccco4)nc23)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(F)(F)C(F)(F)F",
"old_substring": "C7(F)(F)F"
}
|
Can you make molecule C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)F)cc(-c4ccco4)nc23)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCCN(C(=O)c2cnn3c(CC(F)(F)C(F)(F)F)cc(-c4ccco4)nc23)C1
|
C[C@H]1CCCN(C(=O)c2cnn3c(C(F)(F)F)cc(-c4ccco4)nc23)C1
|
C[C@H]1CCCN(C(=O)c2cnn3c(CC(F)(F)C(F)(F)F)cc(-c4ccco4)nc23)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)(F)F",
"old_substring": "C7(F)(F)F"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)NCc1ccccc1OCCO less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1nn(C)cc1NC(=O)NCc1ccccc1OOCOC
|
CCc1nn(C)cc1NC(=O)NCc1ccccc1OCCO
|
CCc1nn(C)cc1NC(=O)NCc1ccccc1OOCOC
| 102
|
{
"fragment_index": 0,
"new_substring": "COCO&",
"old_substring": "C4CO"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)NCc1ccccc1OCCO less soluble in water? The output molecule should be similar to the input molecule.
|
C=COOc1ccccc1CNC(=O)Nc1cn(C)nc1CC
|
CCc1nn(C)cc1NC(=O)NCc1ccccc1OCCO
|
C=COOc1ccccc1CNC(=O)Nc1cn(C)nc1CC
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CO&",
"old_substring": "C4CO"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)NCc1ccccc1OCCO less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)Oc1ccccc1CNC(=O)Nc1cn(C)nc1CC
|
CCc1nn(C)cc1NC(=O)NCc1ccccc1OCCO
|
CCC(=O)Oc1ccccc1CNC(=O)Nc1cn(C)nc1CC
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&=O",
"old_substring": "C4CO"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)NCc1ccccc1OCCO less soluble in water? The output molecule should be similar to the input molecule.
|
C=C=COOc1ccccc1CNC(=O)Nc1cn(C)nc1CC
|
CCc1nn(C)cc1NC(=O)NCc1ccccc1OCCO
|
C=C=COOc1ccccc1CNC(=O)Nc1cn(C)nc1CC
| 102
|
{
"fragment_index": 0,
"new_substring": "C=C=CO&",
"old_substring": "C4CO"
}
|
Can you make molecule CCc1nn(C)cc1NC(=O)NCc1ccccc1OCCO less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1CNC(=O)Nc1cn(C)nc1CC
|
CCc1nn(C)cc1NC(=O)NCc1ccccc1OCCO
|
CCOc1ccccc1CNC(=O)Nc1cn(C)nc1CC
| 102
|
{
"fragment_index": 0,
"new_substring": "CC&",
"old_substring": "C4CO"
}
|
Can you make molecule COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CN(C)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CCCCO1
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CN(C)CCO1
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CCCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCCO1",
"old_substring": "[C@@H]13CN(C)CCO1"
}
|
Can you make molecule COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CN(C)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CC(Cl)=NO1
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CN(C)CCO1
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CC(Cl)=NO1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC(Cl)=NO1",
"old_substring": "[C@@H]13CN(C)CCO1"
}
|
Can you make molecule COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CN(C)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@H](O)C1=CCCC1
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CN(C)CCO1
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@H](O)C1=CCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(O)C1=CCCC1",
"old_substring": "[C@@H]13CN(C)CCO1"
}
|
Can you make molecule COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CN(C)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1C=CCC1
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CN(C)CCO1
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1C=CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&C=CCC1",
"old_substring": "[C@@H]13CN(C)CCO1"
}
|
Can you make molecule COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CN(C)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CCCSC1
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CN(C)CCO1
|
COC(=O)C[C@H](C)S(=O)(=O)C[C@@H]1CCCSC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCSC1",
"old_substring": "[C@@H]13CN(C)CCO1"
}
|
Can you make molecule CC[C@H](Nc1cc(C)nc(COC)n1)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](c1cccc([N+](=O)[O-])c1)N(C)C(=S)Sc1cc(C)nc(COC)n1
|
CC[C@H](Nc1cc(C)nc(COC)n1)c1cccc([N+](=O)[O-])c1
|
CC[C@@H](c1cccc([N+](=O)[O-])c1)N(C)C(=S)Sc1cc(C)nc(COC)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N34"
}
|
Can you make molecule CC[C@H](Nc1cc(C)nc(COC)n1)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](c1cccc([N+](=O)[O-])c1)N1CCN=C1Sc1cc(C)nc(COC)n1
|
CC[C@H](Nc1cc(C)nc(COC)n1)c1cccc([N+](=O)[O-])c1
|
CC[C@@H](c1cccc([N+](=O)[O-])c1)N1CCN=C1Sc1cc(C)nc(COC)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N34"
}
|
Can you make molecule CC[C@H](Nc1cc(C)nc(COC)n1)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](CN1CCC(c2cc(C)nc(COC)n2)CC1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](Nc1cc(C)nc(COC)n1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](CN1CCC(c2cc(C)nc(COC)n2)CC1)c1cccc([N+](=O)[O-])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N34"
}
|
Can you make molecule CC[C@H](Nc1cc(C)nc(COC)n1)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](c1cccc([N+](=O)[O-])c1)c1cccc(-c2cc(C)nc(COC)n2)c1N
|
CC[C@H](Nc1cc(C)nc(COC)n1)c1cccc([N+](=O)[O-])c1
|
CC[C@@H](c1cccc([N+](=O)[O-])c1)c1cccc(-c2cc(C)nc(COC)n2)c1N
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&cccc1&",
"old_substring": "N34"
}
|
Can you make molecule CC[C@H](Nc1cc(C)nc(COC)n1)c1cccc([N+](=O)[O-])c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](c1cc(N)cc(-c2cc(C)nc(COC)n2)c1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](Nc1cc(C)nc(COC)n1)c1cccc([N+](=O)[O-])c1
|
CC[C@H](c1cc(N)cc(-c2cc(C)nc(COC)n2)c1)c1cccc([N+](=O)[O-])c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1cc&cc&c1",
"old_substring": "N34"
}
|
Can you make molecule Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3)cc2nc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3I)cc2nc1C
|
Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3)cc2nc1C
|
Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3I)cc2nc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c17ccc8cc1"
}
|
Can you make molecule Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3)cc2nc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc2ccc(C(=O)Oc3cc(NC(=O)C4CC4)ccc3Br)cc2nc1C
|
Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3)cc2nc1C
|
Cc1nc2ccc(C(=O)Oc3cc(NC(=O)C4CC4)ccc3Br)cc2nc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c17ccc8cc1"
}
|
Can you make molecule Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3)cc2nc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3Cl)cc2nc1C
|
Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3)cc2nc1C
|
Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3Cl)cc2nc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c17ccc8cc1"
}
|
Can you make molecule Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3)cc2nc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc2ccc(C(=O)Oc3cccc(NC(=O)C4CC4)c3Br)cc2nc1C
|
Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3)cc2nc1C
|
Cc1nc2ccc(C(=O)Oc3cccc(NC(=O)C4CC4)c3Br)cc2nc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c17ccc8cc1"
}
|
Can you make molecule Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3)cc2nc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc2ccc(C(=O)Oc3cccc(NC(=O)C4CC4)c3Cl)cc2nc1C
|
Cc1nc2ccc(C(=O)Oc3ccc(NC(=O)C4CC4)cc3)cc2nc1C
|
Cc1nc2ccc(C(=O)Oc3cccc(NC(=O)C4CC4)c3Cl)cc2nc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c17ccc8cc1"
}
|
Can you make molecule C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCC(=O)Nc1ccc(Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCCC(CO)=Nc1ccc(Cl)cn1
|
C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCC(=O)Nc1ccc(Cl)cn1
|
C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCCC(CO)=Nc1ccc(Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C5C4=O"
}
|
Can you make molecule C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCC(=O)Nc1ccc(Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(COC(=O)[C@@H](C)NC1=NS(=O)(=O)c2ccccc21)=N/ONc1ccc(Cl)cn1
|
C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCC(=O)Nc1ccc(Cl)cn1
|
C/C(COC(=O)[C@@H](C)NC1=NS(=O)(=O)c2ccccc21)=N/ONc1ccc(Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C5C4=O"
}
|
Can you make molecule C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCC(=O)Nc1ccc(Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(OC(=O)[C@@H](C)NC1=NS(=O)(=O)c2ccccc21)C(=O)CNc1ccc(Cl)cn1
|
C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCC(=O)Nc1ccc(Cl)cn1
|
CCC(CC)(OC(=O)[C@@H](C)NC1=NS(=O)(=O)c2ccccc21)C(=O)CNc1ccc(Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C5C4=O"
}
|
Can you make molecule C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCC(=O)Nc1ccc(Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OSSC(=O)Nc1ccc(Cl)cn1
|
C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCC(=O)Nc1ccc(Cl)cn1
|
C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OSSC(=O)Nc1ccc(Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C5C4=O"
}
|
Can you make molecule C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCC(=O)Nc1ccc(Cl)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(OC(=O)[C@@H](C)NC1=NS(=O)(=O)c2ccccc21)C(=O)CCNc1ccc(Cl)cn1
|
C[C@@H](NC1=NS(=O)(=O)c2ccccc21)C(=O)OCC(=O)Nc1ccc(Cl)cn1
|
CCC(CC)(OC(=O)[C@@H](C)NC1=NS(=O)(=O)c2ccccc21)C(=O)CCNc1ccc(Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C5C4=O"
}
|
Can you make molecule COCC[S@+]([O-])Cc1cccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCC[S@+]([O-])Cc1cccc(NC(=O)CC(C)(C)N2CC[C@@H](C)C[C@@H]2C)c1
|
COCC[S@+]([O-])Cc1cccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)c1
|
COCC[S@+]([O-])Cc1cccc(NC(=O)CC(C)(C)N2CC[C@@H](C)C[C@@H]2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule COCC[S@+]([O-])Cc1cccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCC[S@+]([O-])Cc1cccc(NC(=O)CCC(C)(C)N2CC[C@@H](C)C[C@@H]2C)c1
|
COCC[S@+]([O-])Cc1cccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)c1
|
COCC[S@+]([O-])Cc1cccc(NC(=O)CCC(C)(C)N2CC[C@@H](C)C[C@@H]2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule COCC[S@+]([O-])Cc1cccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCC[S@+]([O-])Cc1cccc(NC(=O)C[C@@H](Br)N2CC[C@@H](C)C[C@@H]2C)c1
|
COCC[S@+]([O-])Cc1cccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)c1
|
COCC[S@+]([O-])Cc1cccc(NC(=O)C[C@@H](Br)N2CC[C@@H](C)C[C@@H]2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule COCC[S@+]([O-])Cc1cccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCC[S@+]([O-])Cc1cccc(Nc2cc(C)n(N3CC[C@@H](C)C[C@@H]3C)c(=O)c2)c1
|
COCC[S@+]([O-])Cc1cccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)c1
|
COCC[S@+]([O-])Cc1cccc(Nc2cc(C)n(N3CC[C@@H](C)C[C@@H]3C)c(=O)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C34=O"
}
|
Can you make molecule COCC[S@+]([O-])Cc1cccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCC[S@+]([O-])Cc1cccc(Nc2c(C)n(N3CC[C@@H](C)C[C@@H]3C)ccc2=O)c1
|
COCC[S@+]([O-])Cc1cccc(NC(=O)N2CC[C@@H](C)C[C@@H]2C)c1
|
COCC[S@+]([O-])Cc1cccc(Nc2c(C)n(N3CC[C@@H](C)C[C@@H]3C)ccc2=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C34=O"
}
|
Can you make molecule O=C(Nc1ccccc1Cl)c1c[nH]c2nccc(Cl)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sc1c[nH]c2nccc(Cl)c12)Nc1ccccc1Cl
|
O=C(Nc1ccccc1Cl)c1c[nH]c2nccc(Cl)c12
|
O=C(/C=C/Sc1c[nH]c2nccc(Cl)c12)Nc1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(Nc1ccccc1Cl)c1c[nH]c2nccc(Cl)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(Nc2ccccc2Cl)nc1-c1c[nH]c2nccc(Cl)c12
|
O=C(Nc1ccccc1Cl)c1c[nH]c2nccc(Cl)c12
|
O=Cc1sc(Nc2ccccc2Cl)nc1-c1c[nH]c2nccc(Cl)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(Nc1ccccc1Cl)c1c[nH]c2nccc(Cl)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(Nc2ccccc2Cl)sc1-c1c[nH]c2nccc(Cl)c12
|
O=C(Nc1ccccc1Cl)c1c[nH]c2nccc(Cl)c12
|
O=Cc1nc(Nc2ccccc2Cl)sc1-c1c[nH]c2nccc(Cl)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(Nc1ccccc1Cl)c1c[nH]c2nccc(Cl)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccccc1Cl)n1nc(-c2c[nH]c3nccc(Cl)c23)oc1=S
|
O=C(Nc1ccccc1Cl)c1c[nH]c2nccc(Cl)c12
|
O=C(Nc1ccccc1Cl)n1nc(-c2c[nH]c3nccc(Cl)c23)oc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&n1nc&oc1=S",
"old_substring": "O=C35"
}
|
Can you make molecule O=C(Nc1ccccc1Cl)c1c[nH]c2nccc(Cl)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Clc1ccccc1NO/N=C/c1ccc(-c2c[nH]c3nccc(Cl)c23)o1
|
O=C(Nc1ccccc1Cl)c1c[nH]c2nccc(Cl)c12
|
Clc1ccccc1NO/N=C/c1ccc(-c2c[nH]c3nccc(Cl)c23)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C35"
}
|
Can you make molecule CN1C(=O)[C@H](c2nc3ccccc3c(=O)[nH]2)[C@@H](O)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CN1C(=O)[C@H](c2nc3ccsc3c(=O)s2)[C@@H](O)c2ccccc21
|
CN1C(=O)[C@H](c2nc3ccccc3c(=O)[nH]2)[C@@H](O)c2ccccc21
|
CN1C(=O)[C@H](c2nc3ccsc3c(=O)s2)[C@@H](O)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc2ccsc2c(=O)s1",
"old_substring": "c14nc2ccccc2c(=O)[nH]1"
}
|
Can you make molecule CN1C(=O)[C@H](c2nc3ccccc3c(=O)[nH]2)[C@@H](O)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CN1C(=O)[C@H](c2cc3ccccc3c(=O)s2)[C@@H](O)c2ccccc21
|
CN1C(=O)[C@H](c2nc3ccccc3c(=O)[nH]2)[C@@H](O)c2ccccc21
|
CN1C(=O)[C@H](c2cc3ccccc3c(=O)s2)[C@@H](O)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2ccccc2c(=O)s1",
"old_substring": "c14nc2ccccc2c(=O)[nH]1"
}
|
Can you make molecule CN1C(=O)[C@H](c2nc3ccccc3c(=O)[nH]2)[C@@H](O)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CN1C(=O)[C@H](c2csc3ncccc3c2=O)[C@@H](O)c2ccccc21
|
CN1C(=O)[C@H](c2nc3ccccc3c(=O)[nH]2)[C@@H](O)c2ccccc21
|
CN1C(=O)[C@H](c2csc3ncccc3c2=O)[C@@H](O)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&csc2ncccc2c1=O",
"old_substring": "c14nc2ccccc2c(=O)[nH]1"
}
|
Can you make molecule CN1C(=O)[C@H](c2nc3ccccc3c(=O)[nH]2)[C@@H](O)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c([C@H]2C(=O)N(C)c3ccccc3[C@@H]2O)sc2ccccc12
|
CN1C(=O)[C@H](c2nc3ccccc3c(=O)[nH]2)[C@@H](O)c2ccccc21
|
Cc1c([C@H]2C(=O)N(C)c3ccccc3[C@@H]2O)sc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sc2ccccc2c1C",
"old_substring": "c14nc2ccccc2c(=O)[nH]1"
}
|
Can you make molecule CN1C(=O)[C@H](c2nc3ccccc3c(=O)[nH]2)[C@@H](O)c2ccccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c([C@H]2C(=O)N(C)c3ccccc3[C@@H]2O)oc2ccccc12
|
CN1C(=O)[C@H](c2nc3ccccc3c(=O)[nH]2)[C@@H](O)c2ccccc21
|
Cc1c([C@H]2C(=O)N(C)c3ccccc3[C@@H]2O)oc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&oc2ccccc2c1C",
"old_substring": "c14nc2ccccc2c(=O)[nH]1"
}
|
Can you make molecule CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1)C(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1Cl)C(C)=O
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1)C(C)=O
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1Cl)C(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1)C(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1ccc(I)cc1)C(C)=O
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1)C(C)=O
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1ccc(I)cc1)C(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1)C(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1ccc(C)c(I)c1)C(C)=O
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1)C(C)=O
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1ccc(C)c(I)c1)C(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1)C(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1cccc(Br)c1)C(C)=O
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1)C(C)=O
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1cccc(Br)c1)C(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1)C(C)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1cccc(C)c1C)C(C)=O
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1ccccc1)C(C)=O
|
CC[C@H]1CCCCCN1C(=O)CN(CCc1cccc(C)c1C)C(C)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c17ccccc1"
}
|
Can you make molecule C#CCN(C(=O)Nc1ccc(Cl)cc1F)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCC1=C2CCN2CC(C(=O)Nc2ccc(Cl)cc2F)=NC([C@H]2CCS(=O)(=O)C2)=N1
|
C#CCN(C(=O)Nc1ccc(Cl)cc1F)[C@H]1CCS(=O)(=O)C1
|
C#CCC1=C2CCN2CC(C(=O)Nc2ccc(Cl)cc2F)=NC([C@H]2CCS(=O)(=O)C2)=N1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2c&nc&nc2C1",
"old_substring": "N246"
}
|
Can you make molecule C#CCN(C(=O)Nc1ccc(Cl)cc1F)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCC1=C2OCCN2CC(C(=O)Nc2ccc(Cl)cc2F)=CC([C@H]2CCS(=O)(=O)C2)=C1
|
C#CCN(C(=O)Nc1ccc(Cl)cc1F)[C@H]1CCS(=O)(=O)C1
|
C#CCC1=C2OCCN2CC(C(=O)Nc2ccc(Cl)cc2F)=CC([C@H]2CCS(=O)(=O)C2)=C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2c&cc&cc2C1",
"old_substring": "N246"
}
|
Can you make molecule C#CCN(C(=O)Nc1ccc(Cl)cc1F)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCC1([C@H]2CCS(=O)(=O)C2)CCN(C(=O)Nc2ccc(Cl)cc2F)C1
|
C#CCN(C(=O)Nc1ccc(Cl)cc1F)[C@H]1CCS(=O)(=O)C1
|
C#CCC1([C@H]2CCS(=O)(=O)C2)CCN(C(=O)Nc2ccc(Cl)cc2F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N246"
}
|
Can you make molecule C#CCN(C(=O)Nc1ccc(Cl)cc1F)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCC1([C@H]2CCS(=O)(=O)C2)CCCN(C(=O)Nc2ccc(Cl)cc2F)C1
|
C#CCN(C(=O)Nc1ccc(Cl)cc1F)[C@H]1CCS(=O)(=O)C1
|
C#CCC1([C@H]2CCS(=O)(=O)C2)CCCN(C(=O)Nc2ccc(Cl)cc2F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N246"
}
|
Can you make molecule C#CCN(C(=O)Nc1ccc(Cl)cc1F)[C@H]1CCS(=O)(=O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#CCc1oc(C(=O)Nc2ccc(Cl)cc2F)c(C#N)c1[C@H]1CCS(=O)(=O)C1
|
C#CCN(C(=O)Nc1ccc(Cl)cc1F)[C@H]1CCS(=O)(=O)C1
|
C#CCc1oc(C(=O)Nc2ccc(Cl)cc2F)c(C#N)c1[C@H]1CCS(=O)(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N246"
}
|
Can you make molecule Cc1nc(N2CCC[C@@H](C(=O)NCC3CC3)C2)c2cc[nH]c2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(N2CCC[C@@H](C(=O)NC=C3CCC3)C2)c2cc[nH]c2n1
|
Cc1nc(N2CCC[C@@H](C(=O)NCC3CC3)C2)c2cc[nH]c2n1
|
Cc1nc(N2CCC[C@@H](C(=O)NC=C3CCC3)C2)c2cc[nH]c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCC1",
"old_substring": "C18CC1"
}
|
Can you make molecule Cc1nc(N2CCC[C@@H](C(=O)NCC3CC3)C2)c2cc[nH]c2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(N2CCC[C@@H](C(=O)NCC3CCCCC3)C2)c2cc[nH]c2n1
|
Cc1nc(N2CCC[C@@H](C(=O)NCC3CC3)C2)c2cc[nH]c2n1
|
Cc1nc(N2CCC[C@@H](C(=O)NCC3CCCCC3)C2)c2cc[nH]c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCC1",
"old_substring": "C18CC1"
}
|
Can you make molecule Cc1nc(N2CCC[C@@H](C(=O)NCC3CC3)C2)c2cc[nH]c2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(N2CCC[C@@H](C(=O)NC=C3CCCC3)C2)c2cc[nH]c2n1
|
Cc1nc(N2CCC[C@@H](C(=O)NCC3CC3)C2)c2cc[nH]c2n1
|
Cc1nc(N2CCC[C@@H](C(=O)NC=C3CCCC3)C2)c2cc[nH]c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCCC1",
"old_substring": "C18CC1"
}
|
Can you make molecule Cc1nc(N2CCC[C@@H](C(=O)NCC3CC3)C2)c2cc[nH]c2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(N2CCC[C@@H](C(=O)NCC3SCCCS3)C2)c2cc[nH]c2n1
|
Cc1nc(N2CCC[C@@H](C(=O)NCC3CC3)C2)c2cc[nH]c2n1
|
Cc1nc(N2CCC[C@@H](C(=O)NCC3SCCCS3)C2)c2cc[nH]c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "C18CC1"
}
|
Can you make molecule Cc1nc(N2CCC[C@@H](C(=O)NCC3CC3)C2)c2cc[nH]c2n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(N2CCC[C@@H](C(=O)NCC3SCSCS3)C2)c2cc[nH]c2n1
|
Cc1nc(N2CCC[C@@H](C(=O)NCC3CC3)C2)c2cc[nH]c2n1
|
Cc1nc(N2CCC[C@@H](C(=O)NCC3SCSCS3)C2)c2cc[nH]c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCSCS1",
"old_substring": "C18CC1"
}
|
Can you make molecule Nn1c(SCC(F)(F)F)nnc1-c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Nn1c(SCCCC(F)(F)F)nnc1-c1ccc(Cl)cc1
|
Nn1c(SCC(F)(F)F)nnc1-c1ccc(Cl)cc1
|
Nn1c(SCCCC(F)(F)F)nnc1-c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C2C(F)(F)F"
}
|
Can you make molecule Nn1c(SCC(F)(F)F)nnc1-c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Nn1c(SCCCCC(F)(F)F)nnc1-c1ccc(Cl)cc1
|
Nn1c(SCC(F)(F)F)nnc1-c1ccc(Cl)cc1
|
Nn1c(SCCCCC(F)(F)F)nnc1-c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C2C(F)(F)F"
}
|
Can you make molecule Nn1c(SCC(F)(F)F)nnc1-c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Nn1c(SSC(F)(F)F)nnc1-c1ccc(Cl)cc1
|
Nn1c(SCC(F)(F)F)nnc1-c1ccc(Cl)cc1
|
Nn1c(SSC(F)(F)F)nnc1-c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C2C(F)(F)F"
}
|
Can you make molecule Nn1c(SCC(F)(F)F)nnc1-c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Nn1c(SS/C=C/C(F)(F)F)nnc1-c1ccc(Cl)cc1
|
Nn1c(SCC(F)(F)F)nnc1-c1ccc(Cl)cc1
|
Nn1c(SS/C=C/C(F)(F)F)nnc1-c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&/C=C/C(F)(F)F",
"old_substring": "C2C(F)(F)F"
}
|
Can you make molecule Nn1c(SCC(F)(F)F)nnc1-c1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Nn1c(SCC(F)(F)C(F)(F)F)nnc1-c1ccc(Cl)cc1
|
Nn1c(SCC(F)(F)F)nnc1-c1ccc(Cl)cc1
|
Nn1c(SCC(F)(F)C(F)(F)F)nnc1-c1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)(F)F",
"old_substring": "C2C(F)(F)F"
}
|
Can you make molecule C=CCNC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCNSC(=O)Cc1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
|
C=CCNC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
|
C=CCNSC(=O)Cc1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C37=O"
}
|
Can you make molecule C=CCNC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCNC(=O)CCCC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
|
C=CCNC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
|
C=CCNC(=O)CCCC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C37=O"
}
|
Can you make molecule C=CCNC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCNC(=O)CC(C)(C)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
|
C=CCNC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
|
C=CCNC(=O)CC(C)(C)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C37=O"
}
|
Can you make molecule C=CCNC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCNC(=O)CCC(C)(C)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
|
C=CCNC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
|
C=CCNC(=O)CCC(C)(C)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C37=O"
}
|
Can you make molecule C=CCNC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCNSC(=O)[C@@H](C)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
|
C=CCNC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
|
C=CCNSC(=O)[C@@H](C)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C37=O"
}
|
Can you make molecule Cc1ccccc1[C@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1[C@H]1CC(CC(=O)C=Cc2ccnc(Cl)c2)=NO1
|
Cc1ccccc1[C@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCO1
|
Cc1ccccc1[C@H]1CC(CC(=O)C=Cc2ccnc(Cl)c2)=NO1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC(C&)=NO1",
"old_substring": "[C@H]15CN3CCO1"
}
|
Can you make molecule Cc1ccccc1[C@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1[C@H]1C=C(CC(=O)C=Cc2ccnc(Cl)c2)ON1
|
Cc1ccccc1[C@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCO1
|
Cc1ccccc1[C@H]1C=C(CC(=O)C=Cc2ccnc(Cl)c2)ON1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C(C&)ON1",
"old_substring": "[C@H]15CN3CCO1"
}
|
Can you make molecule Cc1ccccc1[C@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1[C@@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCS1
|
Cc1ccccc1[C@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCO1
|
Cc1ccccc1[C@@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCS1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CN&CCS1",
"old_substring": "[C@H]15CN3CCO1"
}
|
Can you make molecule Cc1ccccc1[C@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1[C@H]1CC[C@H](C(=O)C=Cc2ccnc(Cl)c2)O1
|
Cc1ccccc1[C@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCO1
|
Cc1ccccc1[C@H]1CC[C@H](C(=O)C=Cc2ccnc(Cl)c2)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@H]&O1",
"old_substring": "[C@H]15CN3CCO1"
}
|
Can you make molecule Cc1ccccc1[C@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1[C@H]1CCCCN(C(=O)C=Cc2ccnc(Cl)c2)C1
|
Cc1ccccc1[C@H]1CN(C(=O)C=Cc2ccnc(Cl)c2)CCO1
|
Cc1ccccc1[C@H]1CCCCN(C(=O)C=Cc2ccnc(Cl)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCCN&C1",
"old_substring": "[C@H]15CN3CCO1"
}
|
Can you make molecule Cc1cccc(OCCNc2nnnn2-c2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(OCCCCNc2nnnn2-c2ccccc2)c1
|
Cc1cccc(OCCNc2nnnn2-c2ccccc2)c1
|
Cc1cccc(OCCCCNc2nnnn2-c2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C3C5"
}
|
Can you make molecule Cc1cccc(OCCNc2nnnn2-c2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(OCCCCCNc2nnnn2-c2ccccc2)c1
|
Cc1cccc(OCCNc2nnnn2-c2ccccc2)c1
|
Cc1cccc(OCCCCCNc2nnnn2-c2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C3C5"
}
|
Can you make molecule Cc1cccc(OCCNc2nnnn2-c2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(OC2CC(Nc3nnnn3-c3ccccc3)C2)c1
|
Cc1cccc(OCCNc2nnnn2-c2ccccc2)c1
|
Cc1cccc(OC2CC(Nc3nnnn3-c3ccccc3)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C3C5"
}
|
Can you make molecule Cc1cccc(OCCNc2nnnn2-c2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(O[C@@H](C)CCNc2nnnn2-c2ccccc2)c1
|
Cc1cccc(OCCNc2nnnn2-c2ccccc2)c1
|
Cc1cccc(O[C@@H](C)CCNc2nnnn2-c2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C3C5"
}
|
Can you make molecule Cc1cccc(OCCNc2nnnn2-c2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(OC2CCC(Nc3nnnn3-c3ccccc3)CC2)c1
|
Cc1cccc(OCCNc2nnnn2-c2ccccc2)c1
|
Cc1cccc(OC2CCC(Nc3nnnn3-c3ccccc3)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C3C5"
}
|
Can you make molecule CC=CCC[NH2+][C@@H]1CCc2ccc(F)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC=CCC[C@H](C)C[NH2+][C@@H]1CCc2ccc(F)cc21
|
CC=CCC[NH2+][C@@H]1CCc2ccc(F)cc21
|
CC=CCC[C@H](C)C[NH2+][C@@H]1CCc2ccc(F)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@H](C)C&",
"old_substring": "C=4CC3"
}
|
Can you make molecule CC=CCC[NH2+][C@@H]1CCc2ccc(F)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC=CCCCC[NH2+][C@@H]1CCc2ccc(F)cc21
|
CC=CCC[NH2+][C@@H]1CCc2ccc(F)cc21
|
CC=CCCCC[NH2+][C@@H]1CCc2ccc(F)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C=4CC3"
}
|
Can you make molecule CC=CCC[NH2+][C@@H]1CCc2ccc(F)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC=CCC[C@@H](C)C[NH2+][C@@H]1CCc2ccc(F)cc21
|
CC=CCC[NH2+][C@@H]1CCc2ccc(F)cc21
|
CC=CCC[C@@H](C)C[NH2+][C@@H]1CCc2ccc(F)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@@H](C)C&",
"old_substring": "C=4CC3"
}
|
Can you make molecule CC=CCC[NH2+][C@@H]1CCc2ccc(F)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC=C1CCC([NH2+][C@@H]2CCc3ccc(F)cc32)CC1
|
CC=CCC[NH2+][C@@H]1CCc2ccc(F)cc21
|
CC=C1CCC([NH2+][C@@H]2CCc3ccc(F)cc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C=4CC3"
}
|
Can you make molecule CC=CCC[NH2+][C@@H]1CCc2ccc(F)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC=CC(C)(C)C[NH2+][C@@H]1CCc2ccc(F)cc21
|
CC=CCC[NH2+][C@@H]1CCc2ccc(F)cc21
|
CC=CC(C)(C)C[NH2+][C@@H]1CCc2ccc(F)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C&)C&",
"old_substring": "C=4CC3"
}
|
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