prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule COc1cc(Br)c(C[NH2+]C[C@H](C)O)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)c(CCCC[NH2+]C[C@H](C)O)cc1OC
|
COc1cc(Br)c(C[NH2+]C[C@H](C)O)cc1OC
|
COc1cc(Br)c(CCCC[NH2+]C[C@H](C)O)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C46"
}
|
Can you make molecule COc1cc(Br)c(C[NH2+]C[C@H](C)O)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)c(CCCCC[NH2+]C[C@H](C)O)cc1OC
|
COc1cc(Br)c(C[NH2+]C[C@H](C)O)cc1OC
|
COc1cc(Br)c(CCCCC[NH2+]C[C@H](C)O)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C46"
}
|
Can you make molecule COc1cc(Br)c(C[NH2+]C[C@H](C)O)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)c(C2CC([NH2+]C[C@H](C)O)C2)cc1OC
|
COc1cc(Br)c(C[NH2+]C[C@H](C)O)cc1OC
|
COc1cc(Br)c(C2CC([NH2+]C[C@H](C)O)C2)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C46"
}
|
Can you make molecule COc1cc(Br)c(C[NH2+]C[C@H](C)O)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)c(SC(=S)O[NH2+]C[C@H](C)O)cc1OC
|
COc1cc(Br)c(C[NH2+]C[C@H](C)O)cc1OC
|
COc1cc(Br)c(SC(=S)O[NH2+]C[C@H](C)O)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C46"
}
|
Can you make molecule COc1cc(Br)c(C[NH2+]C[C@H](C)O)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc(Br)c(NC(=S)S[NH2+]C[C@H](C)O)cc1OC
|
COc1cc(Br)c(C[NH2+]C[C@H](C)O)cc1OC
|
COc1cc(Br)c(NC(=S)S[NH2+]C[C@H](C)O)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C46"
}
|
Can you make molecule C[C@H](CNC(=O)c1cccc(C(F)(F)F)c1F)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CNC(=O)c1cccc(SC(F)(F)F)c1F)c1ccncc1
|
C[C@H](CNC(=O)c1cccc(C(F)(F)F)c1F)c1ccncc1
|
C[C@H](CNC(=O)c1cccc(SC(F)(F)F)c1F)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule C[C@H](CNC(=O)c1cccc(C(F)(F)F)c1F)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CNC(=O)c1cccc(CCCC(F)(F)F)c1F)c1ccncc1
|
C[C@H](CNC(=O)c1cccc(C(F)(F)F)c1F)c1ccncc1
|
C[C@H](CNC(=O)c1cccc(CCCC(F)(F)F)c1F)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule C[C@H](CNC(=O)c1cccc(C(F)(F)F)c1F)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CNC(=O)c1cccc(CCCCC(F)(F)F)c1F)c1ccncc1
|
C[C@H](CNC(=O)c1cccc(C(F)(F)F)c1F)c1ccncc1
|
C[C@H](CNC(=O)c1cccc(CCCCC(F)(F)F)c1F)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule C[C@H](CNC(=O)c1cccc(C(F)(F)F)c1F)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CNC(=O)c1cccc(C(F)(F)C(F)(F)F)c1F)c1ccncc1
|
C[C@H](CNC(=O)c1cccc(C(F)(F)F)c1F)c1ccncc1
|
C[C@H](CNC(=O)c1cccc(C(F)(F)C(F)(F)F)c1F)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(F)(F)C(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule C[C@H](CNC(=O)c1cccc(C(F)(F)F)c1F)c1ccncc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CNC(=O)c1cccc(CC(F)(F)C(F)(F)F)c1F)c1ccncc1
|
C[C@H](CNC(=O)c1cccc(C(F)(F)F)c1F)c1ccncc1
|
C[C@H](CNC(=O)c1cccc(CC(F)(F)C(F)(F)F)c1F)c1ccncc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule C[C@H]([NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)c1ccc(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(C)(C)c1ccc(Br)s1)[NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1
|
C[C@H]([NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)c1ccc(Br)s1
|
C[C@H](CC(C)(C)c1ccc(Br)s1)[NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@H]25"
}
|
Can you make molecule C[C@H]([NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)c1ccc(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC[NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)CC(=O)c1ccc(Br)s1
|
C[C@H]([NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)c1ccc(Br)s1
|
C[C@H](CC[NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)CC(=O)c1ccc(Br)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "C[C@H]25"
}
|
Can you make molecule C[C@H]([NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)c1ccc(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Cc1ccc(Br)s1)[C@H](C)[NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1
|
C[C@H]([NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)c1ccc(Br)s1
|
C[C@H](Cc1ccc(Br)s1)[C@H](C)[NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&[C@H](C)C&",
"old_substring": "C[C@H]25"
}
|
Can you make molecule C[C@H]([NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)c1ccc(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CC[NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)CC(=O)c1ccc(Br)s1
|
C[C@H]([NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)c1ccc(Br)s1
|
C[C@@H](CC[NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)CC(=O)c1ccc(Br)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@H]25"
}
|
Can you make molecule C[C@H]([NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)c1ccc(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](CCc1ccc(Br)s1)[NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1
|
C[C@H]([NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1)c1ccc(Br)s1
|
CCC[C@@H](CCc1ccc(Br)s1)[NH2+][C@@H]1CC(=O)N(C(C)(C)C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&",
"old_substring": "C[C@H]25"
}
|
Can you make molecule CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(SC(F)(F)F)cc1
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)F)cc1
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(SC(F)(F)F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(CCCC(F)(F)F)cc1
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)F)cc1
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(CCCC(F)(F)F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(CCCCC(F)(F)F)cc1
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)F)cc1
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(CCCCC(F)(F)F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)C(F)(F)F)cc1
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)F)cc1
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)C(F)(F)F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(F)(F)C(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)F)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(CC(F)(F)C(F)(F)F)cc1
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(C(F)(F)F)cc1
|
CN(Cc1nccn1CC(F)(F)F)S(=O)(=O)c1ccc(CC(F)(F)C(F)(F)F)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1I
|
Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1
|
Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "Cc1ccc6cc1"
}
|
Can you make molecule Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1Cl
|
Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1
|
Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1Cl",
"old_substring": "Cc1ccc6cc1"
}
|
Can you make molecule Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(I)ccc1-c1cc(C(=O)[O-])c2c(-c3cccc([N+](=O)[O-])c3)[nH]nc2n1
|
Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1
|
Cc1cc(I)ccc1-c1cc(C(=O)[O-])c2c(-c3cccc([N+](=O)[O-])c3)[nH]nc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(I)ccc1&",
"old_substring": "Cc1ccc6cc1"
}
|
Can you make molecule Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(I)c(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)c1
|
Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1
|
Cc1ccc(I)c(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(I)c&c1",
"old_substring": "Cc1ccc6cc1"
}
|
Can you make molecule Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Br)c(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)c1
|
Cc1ccc(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)cc1
|
Cc1ccc(Br)c(-c2cc(C(=O)[O-])c3c(-c4cccc([N+](=O)[O-])c4)[nH]nc3n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(Br)c&c1",
"old_substring": "Cc1ccc6cc1"
}
|
Can you make molecule COc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N
|
COc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N
|
COCc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N
|
COc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N
|
COCSc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N
|
COc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N
|
CC(=O)Sc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCC[C@H](NS(=O)(=O)c2ccc(C(=O)CS)c(N)c2)C1
|
COc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N
|
C[C@@H]1CCC[C@H](NS(=O)(=O)c2ccc(C(=O)CS)c(N)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO3"
}
|
Can you make molecule COc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCC[C@H](NS(=O)(=O)c2ccc(C(=O)CI)c(N)c2)C1
|
COc1ccc(S(=O)(=O)N[C@H]2CCC[C@@H](C)C2)cc1N
|
C[C@@H]1CCC[C@H](NS(=O)(=O)c2ccc(C(=O)CI)c(N)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO3"
}
|
Can you make molecule CC(C)[C@@H](C)NC(=O)N1CCSC(C)(C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](C)NC(=O)CC(C)(C)N1CCSC(C)(C)C1
|
CC(C)[C@@H](C)NC(=O)N1CCSC(C)(C)C1
|
CC(C)[C@@H](C)NC(=O)CC(C)(C)N1CCSC(C)(C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)[C@@H](C)NC(=O)N1CCSC(C)(C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](C)NC(=O)CCC(C)(C)N1CCSC(C)(C)C1
|
CC(C)[C@@H](C)NC(=O)N1CCSC(C)(C)C1
|
CC(C)[C@@H](C)NC(=O)CCC(C)(C)N1CCSC(C)(C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)[C@@H](C)NC(=O)N1CCSC(C)(C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](C)NC(=O)C[C@@H](Br)N1CCSC(C)(C)C1
|
CC(C)[C@@H](C)NC(=O)N1CCSC(C)(C)C1
|
CC(C)[C@@H](C)NC(=O)C[C@@H](Br)N1CCSC(C)(C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)[C@@H](C)NC(=O)N1CCSC(C)(C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(N[C@H](C)C(C)C)cc(=O)n1N1CCSC(C)(C)C1
|
CC(C)[C@@H](C)NC(=O)N1CCSC(C)(C)C1
|
Cc1cc(N[C@H](C)C(C)C)cc(=O)n1N1CCSC(C)(C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)[C@@H](C)NC(=O)N1CCSC(C)(C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(N[C@H](C)C(C)C)c(=O)ccn1N1CCSC(C)(C)C1
|
CC(C)[C@@H](C)NC(=O)N1CCSC(C)(C)C1
|
Cc1c(N[C@H](C)C(C)C)c(=O)ccn1N1CCSC(C)(C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C23=O"
}
|
Can you make molecule CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(OS(C)(=O)=O)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(CS(C)(=O)=O)cc21
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(OS(C)(=O)=O)cc21
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(CS(C)(=O)=O)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&S(C)(=O)=O",
"old_substring": "O3S(C)(=O)=O"
}
|
Can you make molecule CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(OS(C)(=O)=O)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(CCS(C)(=O)=O)cc21
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(OS(C)(=O)=O)cc21
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(CCS(C)(=O)=O)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CS(C)(=O)=O",
"old_substring": "O3S(C)(=O)=O"
}
|
Can you make molecule CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(OS(C)(=O)=O)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(S(=O)(=O)C(C)C)cc21
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(OS(C)(=O)=O)cc21
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(S(=O)(=O)C(C)C)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)S&(=O)=O",
"old_substring": "O3S(C)(=O)=O"
}
|
Can you make molecule CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(OS(C)(=O)=O)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(S(=O)(=O)CCCCO)cc21
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(OS(C)(=O)=O)cc21
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(S(=O)(=O)CCCCO)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "S&(=O)(=O)CCCCO",
"old_substring": "O3S(C)(=O)=O"
}
|
Can you make molecule CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(OS(C)(=O)=O)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(S(=O)(=O)CC(C)C)cc21
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(OS(C)(=O)=O)cc21
|
CC1=CC(C)(C)N(S(C)(=O)=O)c2ccc(S(=O)(=O)CC(C)C)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CS&(=O)=O",
"old_substring": "O3S(C)(=O)=O"
}
|
Can you make molecule Cc1ccccc1/N=C1\S[C@H](CC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1/N=C1\S[C@H](CCC(CO)=Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1
|
Cc1ccccc1/N=C1\S[C@H](CC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1
|
Cc1ccccc1/N=C1\S[C@H](CCC(CO)=Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C6C3=O"
}
|
Can you make molecule Cc1ccccc1/N=C1\S[C@H](CC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(C[C@H]1S/C(=N\c2ccccc2C)N(Cc2ccccn2)C1=O)=N/ONc1cccc(Cl)c1C
|
Cc1ccccc1/N=C1\S[C@H](CC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1
|
C/C(C[C@H]1S/C(=N\c2ccccc2C)N(Cc2ccccn2)C1=O)=N/ONc1cccc(Cl)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C6C3=O"
}
|
Can you make molecule Cc1ccccc1/N=C1\S[C@H](CC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CNc1cccc(Cl)c1C)[C@H]1S/C(=N\c2ccccc2C)N(Cc2ccccn2)C1=O
|
Cc1ccccc1/N=C1\S[C@H](CC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1
|
CCC(CC)(C(=O)CNc1cccc(Cl)c1C)[C@H]1S/C(=N\c2ccccc2C)N(Cc2ccccn2)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C6C3=O"
}
|
Can you make molecule Cc1ccccc1/N=C1\S[C@H](CC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1/N=C1\S[C@H](SSC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1
|
Cc1ccccc1/N=C1\S[C@H](CC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1
|
Cc1ccccc1/N=C1\S[C@H](SSC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C6C3=O"
}
|
Can you make molecule Cc1ccccc1/N=C1\S[C@H](CC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CCNc1cccc(Cl)c1C)[C@H]1S/C(=N\c2ccccc2C)N(Cc2ccccn2)C1=O
|
Cc1ccccc1/N=C1\S[C@H](CC(=O)Nc2cccc(Cl)c2C)C(=O)N1Cc1ccccn1
|
CCC(CC)(C(=O)CCNc1cccc(Cl)c1C)[C@H]1S/C(=N\c2ccccc2C)N(Cc2ccccn2)C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C6C3=O"
}
|
Can you make molecule Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCCCC2)c1
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCC2)c1
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCCCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCCC1",
"old_substring": "C14CCCCC1"
}
|
Can you make molecule Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NSC2=CCCCCC2)c1
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCC2)c1
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NSC2=CCCCCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(S&)CCCCC1",
"old_substring": "C14CCCCC1"
}
|
Can you make molecule Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(N=CC2CCCCC2)c1
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCC2)c1
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(N=CC2CCCCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&C1CCCCC1",
"old_substring": "C14CCCCC1"
}
|
Can you make molecule Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCCCCCCCC2)c1
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCC2)c1
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCCCCCCCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCCCCCCC1",
"old_substring": "C14CCCCC1"
}
|
Can you make molecule Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCC2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2(C#N)CCCCCCC2)c1
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2CCCCC2)c1
|
Cc1cc[n+](C(=O)c2ccc([N+](=O)[O-])cc2C)c(NC2(C#N)CCCCCCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCCCCCC1",
"old_substring": "C14CCCCC1"
}
|
Can you make molecule COc1c(F)cc([C@H]([NH3+])CO)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CC#CC[C@H]([NH3+])c1cc(F)c(OC)c(Cl)c1
|
COc1c(F)cc([C@H]([NH3+])CO)cc1Cl
|
CC#CC[C@H]([NH3+])c1cc(F)c(OC)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC#CC[C@@H]3[NH3+]",
"old_substring": "[C@@H]3([NH3+])CO"
}
|
Can you make molecule COc1c(F)cc([C@H]([NH3+])CO)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
COc1c(F)cc([C@@](C)(O)CC[NH3+])cc1Cl
|
COc1c(F)cc([C@H]([NH3+])CO)cc1Cl
|
COc1c(F)cc([C@@](C)(O)CC[NH3+])cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@]3(O)CC[NH3+]",
"old_substring": "[C@@H]3([NH3+])CO"
}
|
Can you make molecule COc1c(F)cc([C@H]([NH3+])CO)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@H]([NH3+])Cc1cc(F)c(OC)c(Cl)c1
|
COc1c(F)cc([C@H]([NH3+])CO)cc1Cl
|
CCCC[C@H]([NH3+])Cc1cc(F)c(OC)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]([NH3+])C3",
"old_substring": "[C@@H]3([NH3+])CO"
}
|
Can you make molecule COc1c(F)cc([C@H]([NH3+])CO)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H]([NH3+])CCc1cc(F)c(OC)c(Cl)c1
|
COc1c(F)cc([C@H]([NH3+])CO)cc1Cl
|
CCC[C@H]([NH3+])CCc1cc(F)c(OC)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]([NH3+])CC3",
"old_substring": "[C@@H]3([NH3+])CO"
}
|
Can you make molecule COc1c(F)cc([C@H]([NH3+])CO)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@@H](C[NH3+])c1cc(F)c(OC)c(Cl)c1
|
COc1c(F)cc([C@H]([NH3+])CO)cc1Cl
|
CCC[C@@H](C[NH3+])c1cc(F)c(OC)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]3C[NH3+]",
"old_substring": "[C@@H]3([NH3+])CO"
}
|
Can you make molecule C[C@H]([NH2+][C@@H](C)C[C@@H](O)c1ccco1)c1nc2ccccc2n1C(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C[C@@H](O)c1ccco1)[NH2+][C@H](CCl)CCCc1nc2ccccc2n1C(F)F
|
C[C@H]([NH2+][C@@H](C)C[C@@H](O)c1ccco1)c1nc2ccccc2n1C(F)F
|
C[C@@H](C[C@@H](O)c1ccco1)[NH2+][C@H](CCl)CCCc1nc2ccccc2n1C(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]47C"
}
|
Can you make molecule C[C@H]([NH2+][C@@H](C)C[C@@H](O)c1ccco1)c1nc2ccccc2n1C(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C[C@@H](O)c1ccco1)[NH2+][C@@H]1N=NC=C1CCc1nc2ccccc2n1C(F)F
|
C[C@H]([NH2+][C@@H](C)C[C@@H](O)c1ccco1)c1nc2ccccc2n1C(F)F
|
C[C@@H](C[C@@H](O)c1ccco1)[NH2+][C@@H]1N=NC=C1CCc1nc2ccccc2n1C(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N=NC=C1CC&",
"old_substring": "[C@@H]47C"
}
|
Can you make molecule C[C@H]([NH2+][C@@H](C)C[C@@H](O)c1ccco1)c1nc2ccccc2n1C(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C[C@@H](O)c1ccco1)[NH2+][C@@H]1CC[C@@H](c2nc3ccccc3n2C(F)F)C1
|
C[C@H]([NH2+][C@@H](C)C[C@@H](O)c1ccco1)c1nc2ccccc2n1C(F)F
|
C[C@@H](C[C@@H](O)c1ccco1)[NH2+][C@@H]1CC[C@@H](c2nc3ccccc3n2C(F)F)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]47C"
}
|
Can you make molecule C[C@H]([NH2+][C@@H](C)C[C@@H](O)c1ccco1)c1nc2ccccc2n1C(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](C[C@@H](O)c1ccco1)[NH2+][C@H](C)C(C)(C)Cc1nc2ccccc2n1C(F)F
|
C[C@H]([NH2+][C@@H](C)C[C@@H](O)c1ccco1)c1nc2ccccc2n1C(F)F
|
C[C@@H](C[C@@H](O)c1ccco1)[NH2+][C@H](C)C(C)(C)Cc1nc2ccccc2n1C(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(C)C(C)(C)C&",
"old_substring": "[C@@H]47C"
}
|
Can you make molecule C[C@H]([NH2+][C@@H](C)C[C@@H](O)c1ccco1)c1nc2ccccc2n1C(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1nc2ccccc2n1C(F)F)[NH2+][C@@H](C)C[C@@H](O)c1ccco1
|
C[C@H]([NH2+][C@@H](C)C[C@@H](O)c1ccco1)c1nc2ccccc2n1C(F)F
|
CC[C@@H](CCc1nc2ccccc2n1C(F)F)[NH2+][C@@H](C)C[C@@H](O)c1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@@H]47C"
}
|
Can you make molecule CC[NH+](CCO[C@H]1CCCCO1)CC1CC[NH2+]CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+]1CCN2CCC(CC2)C1.O[C@H]1CCCCO1
|
CC[NH+](CCO[C@H]1CCCCO1)CC1CC[NH2+]CC1
|
CC[NH+]1CCN2CCC(CC2)C1.O[C@H]1CCCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCN&CC1",
"old_substring": "C17CC[NH2+]CC1"
}
|
Can you make molecule CC[NH+](CCO[C@H]1CCCCO1)CC1CC[NH2+]CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+]1CCC2CCC(CC2)C1.O[C@H]1CCCCO1
|
CC[NH+](CCO[C@H]1CCCCO1)CC1CC[NH2+]CC1
|
CC[NH+]1CCC2CCC(CC2)C1.O[C@H]1CCCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C17CC[NH2+]CC1"
}
|
Can you make molecule CC[NH+](CCO[C@H]1CCCCO1)CC1CC[NH2+]CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+]1CCC2CC(C2)C1.O[C@H]1CCCCO1
|
CC[NH+](CCO[C@H]1CCCCO1)CC1CC[NH2+]CC1
|
CC[NH+]1CCC2CC(C2)C1.O[C@H]1CCCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C17CC[NH2+]CC1"
}
|
Can you make molecule CC[NH+](CCO[C@H]1CCCCO1)CC1CC[NH2+]CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[NH+]1CCC2=CN=N[C@H]2CC1.O[C@H]1CCCCO1
|
CC[NH+](CCO[C@H]1CCCCO1)CC1CC[NH2+]CC1
|
CC[NH+]1CCC2=CN=N[C@H]2CC1.O[C@H]1CCCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(C&)[C@H]&N=N1",
"old_substring": "C17CC[NH2+]CC1"
}
|
Can you make molecule CC[NH+](CCO[C@H]1CCCCO1)CC1CC[NH2+]CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[C@H]1CCCC[NH+](CC)C1.O[C@H]1CCCCO1
|
CC[NH+](CCO[C@H]1CCCCO1)CC1CC[NH2+]CC1
|
CCC[C@H]1CCCC[NH+](CC)C1.O[C@H]1CCCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC[C@H]&CC&",
"old_substring": "C17CC[NH2+]CC1"
}
|
Can you make molecule Cc1c(C(=O)N(C)CCOCC2CC2)nnn1-c1ccc2ncccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)[C@H](N)CCCCOCC2CC2)nnn1-c1ccc2ncccc2c1
|
Cc1c(C(=O)N(C)CCOCC2CC2)nnn1-c1ccc2ncccc2c1
|
Cc1c(C(=O)[C@H](N)CCCCOCC2CC2)nnn1-c1ccc2ncccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N[C@@H]&CC&",
"old_substring": "N36C"
}
|
Can you make molecule Cc1c(C(=O)N(C)CCOCC2CC2)nnn1-c1ccc2ncccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)N2CCN=C2CCCOCC2CC2)nnn1-c1ccc2ncccc2c1
|
Cc1c(C(=O)N(C)CCOCC2CC2)nnn1-c1ccc2ncccc2c1
|
Cc1c(C(=O)N2CCN=C2CCCOCC2CC2)nnn1-c1ccc2ncccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1C&",
"old_substring": "N36C"
}
|
Can you make molecule Cc1c(C(=O)N(C)CCOCC2CC2)nnn1-c1ccc2ncccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)c2cc(C#N)c(CCOCC3CC3)s2)nnn1-c1ccc2ncccc2c1
|
Cc1c(C(=O)N(C)CCOCC2CC2)nnn1-c1ccc2ncccc2c1
|
Cc1c(C(=O)c2cc(C#N)c(CCOCC3CC3)s2)nnn1-c1ccc2ncccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N36C"
}
|
Can you make molecule Cc1c(C(=O)N(C)CCOCC2CC2)nnn1-c1ccc2ncccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)c2ccc(CCOCC3CC3)c(C#N)c2)nnn1-c1ccc2ncccc2c1
|
Cc1c(C(=O)N(C)CCOCC2CC2)nnn1-c1ccc2ncccc2c1
|
Cc1c(C(=O)c2ccc(CCOCC3CC3)c(C#N)c2)nnn1-c1ccc2ncccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N36C"
}
|
Can you make molecule Cc1c(C(=O)N(C)CCOCC2CC2)nnn1-c1ccc2ncccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)ON=C2CCN(CCOCC3CC3)CC2)nnn1-c1ccc2ncccc2c1
|
Cc1c(C(=O)N(C)CCOCC2CC2)nnn1-c1ccc2ncccc2c1
|
Cc1c(C(=O)ON=C2CCN(CCOCC3CC3)CC2)nnn1-c1ccc2ncccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "N36C"
}
|
Can you make molecule NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccc(I)cc1F
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1F
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccc(I)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1F",
"old_substring": "c14ccccc1F"
}
|
Can you make molecule NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1cc(I)ccc1F
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1F
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1cc(I)ccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(I)ccc1F",
"old_substring": "c14ccccc1F"
}
|
Can you make molecule NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1Cl
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1F
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c14ccccc1F"
}
|
Can you make molecule NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1cc(F)ccc1Br
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1F
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1cc(F)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1Br",
"old_substring": "c14ccccc1F"
}
|
Can you make molecule NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccc(F)cc1Cl
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccccc1F
|
NC(=O)c1nc(-c2ccc(Cl)c(Cl)c2)nc2c1[nH]c(=O)n2-c1ccc(F)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c14ccccc1F"
}
|
Can you make molecule N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCCC2)c(Cl)c1)c1nc2ccccc2[n-]1
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCCC2)c(Cl)c1)c1nc2ccccc2[n-]1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC1",
"old_substring": "N13CCOCC1"
}
|
Can you make molecule N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCCCC2)c(Cl)c1)c1nc2ccccc2[n-]1
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCCCC2)c(Cl)c1)c1nc2ccccc2[n-]1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCC1",
"old_substring": "N13CCOCC1"
}
|
Can you make molecule N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCSCC2)c(Cl)c1)c1nc2ccccc2[n-]1
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCSCC2)c(Cl)c1)c1nc2ccccc2[n-]1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSCC1",
"old_substring": "N13CCOCC1"
}
|
Can you make molecule N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CC=CC2)c(Cl)c1)c1nc2ccccc2[n-]1
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CC=CC2)c(Cl)c1)c1nc2ccccc2[n-]1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC=CC1",
"old_substring": "N13CCOCC1"
}
|
Can you make molecule N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C/C(=N/Nc1ccc(S(=O)(=O)SSN2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1
|
N#C/C(=N/Nc1ccc(S(=O)(=O)N2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1
|
N#C/C(=N/Nc1ccc(S(=O)(=O)SSN2CCOCC2)c(Cl)c1)c1nc2ccccc2[n-]1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SN1CCOCC1",
"old_substring": "N13CCOCC1"
}
|
Can you make molecule CCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1
|
CCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1
|
C=CSOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC5"
}
|
Can you make molecule CCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1
|
CCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1
|
C=CCCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC5"
}
|
Can you make molecule CCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#CC1=C(N)NC(SCC(=O)OCCCCl)=C(C(=O)Nc2ccccc2)C12CCCCC2
|
CCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1
|
N#CC1=C(N)NC(SCC(=O)OCCCCl)=C(C(=O)Nc2ccccc2)C12CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC5"
}
|
Can you make molecule CCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#CC1=C(N)NC(SCC(=O)OCCCCS)=C(C(=O)Nc2ccccc2)C12CCCCC2
|
CCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1
|
N#CC1=C(N)NC(SCC(=O)OCCCCS)=C(C(=O)Nc2ccccc2)C12CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC5"
}
|
Can you make molecule CCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#CC1=C(N)NC(SCC(=O)OCCCBr)=C(C(=O)Nc2ccccc2)C12CCCCC2
|
CCOC(=O)CSC1=C(C(=O)Nc2ccccc2)C2(CCCCC2)C(C#N)=C(N)N1
|
N#CC1=C(N)NC(SCC(=O)OCCCBr)=C(C(=O)Nc2ccccc2)C12CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC5"
}
|
Can you make molecule O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3ccsc3)o2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(-c2nnc([C@@H]3CCCN(C(=O)COc4ccc(F)cc4)C3)o2)sc1C
|
O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3ccsc3)o2)C1
|
Cc1cc(-c2nnc([C@@H]3CCCN(C(=O)COc4ccc(F)cc4)C3)o2)sc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&sc1C",
"old_substring": "c18ccsc1"
}
|
Can you make molecule O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3ccsc3)o2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(-c2nnc([C@@H]3CCCN(C(=O)COc4ccc(F)cc4)C3)o2)c(C)s1
|
O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3ccsc3)o2)C1
|
Cc1cc(-c2nnc([C@@H]3CCCN(C(=O)COc4ccc(F)cc4)C3)o2)c(C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(C)sc1C",
"old_substring": "c18ccsc1"
}
|
Can you make molecule O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3ccsc3)o2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3sccc3Br)o2)C1
|
O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3ccsc3)o2)C1
|
O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3sccc3Br)o2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sccc1Br",
"old_substring": "c18ccsc1"
}
|
Can you make molecule O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3ccsc3)o2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3cc4sccc4s3)o2)C1
|
O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3ccsc3)o2)C1
|
O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3cc4sccc4s3)o2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2sccc2s1",
"old_substring": "c18ccsc1"
}
|
Can you make molecule O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3ccsc3)o2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3cc(Cl)sc3Cl)o2)C1
|
O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3ccsc3)o2)C1
|
O=C(COc1ccc(F)cc1)N1CCC[C@@H](c2nnc(-c3cc(Cl)sc3Cl)o2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Cl)sc1Cl",
"old_substring": "c18ccsc1"
}
|
Can you make molecule CC(C)Oc1cccnc1C(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Oc1cccnc1C(=O)N[C@@H](CCC(F)(F)F)C(C)(C)C
|
CC(C)Oc1cccnc1C(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1
|
CC(C)Oc1cccnc1C(=O)N[C@@H](CCC(F)(F)F)C(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC&)C(C)(C)C",
"old_substring": "[C@H]15CCC[C@@H]7C1"
}
|
Can you make molecule CC(C)Oc1cccnc1C(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Oc1cccnc1C(=O)N[C@@H](C)CC(C)(C)CC(F)(F)F
|
CC(C)Oc1cccnc1C(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1
|
CC(C)Oc1cccnc1C(=O)N[C@@H](C)CC(C)(C)CC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(C)CC(C)(C)C&",
"old_substring": "[C@H]15CCC[C@@H]7C1"
}
|
Can you make molecule CC(C)Oc1cccnc1C(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](CCC(F)(F)F)NC(=O)c1ncccc1OC(C)C
|
CC(C)Oc1cccnc1C(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1
|
CCCC[C@@H](CCC(F)(F)F)NC(=O)c1ncccc1OC(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]&CC&",
"old_substring": "[C@H]15CCC[C@@H]7C1"
}
|
Can you make molecule CC(C)Oc1cccnc1C(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Oc1cccnc1C(=O)N=CCC[C@@H](C)CC(F)(F)F
|
CC(C)Oc1cccnc1C(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1
|
CC(C)Oc1cccnc1C(=O)N=CCC[C@@H](C)CC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@@H](C)C&",
"old_substring": "[C@H]15CCC[C@@H]7C1"
}
|
Can you make molecule CC(C)Oc1cccnc1C(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Oc1cccnc1C(=O)N=CCC[C@H](C)CC(F)(F)F
|
CC(C)Oc1cccnc1C(=O)N[C@H]1CCC[C@@H](C(F)(F)F)C1
|
CC(C)Oc1cccnc1C(=O)N=CCC[C@H](C)CC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@H](C)C&",
"old_substring": "[C@H]15CCC[C@@H]7C1"
}
|
Can you make molecule CSCCc1ccc(N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSCCCCc1ccc(N)cc1
|
CSCCc1ccc(N)cc1
|
CSCCCCc1ccc(N)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C2C3"
}
|
Can you make molecule CSCCc1ccc(N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSCCCCCc1ccc(N)cc1
|
CSCCc1ccc(N)cc1
|
CSCCCCCc1ccc(N)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C2C3"
}
|
Can you make molecule CSCCc1ccc(N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSC1CC(c2ccc(N)cc2)C1
|
CSCCc1ccc(N)cc1
|
CSC1CC(c2ccc(N)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C2C3"
}
|
Can you make molecule CSCCc1ccc(N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CS[C@@H](C)CCc1ccc(N)cc1
|
CSCCc1ccc(N)cc1
|
CS[C@@H](C)CCc1ccc(N)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C2C3"
}
|
Can you make molecule CSCCc1ccc(N)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSC1CCC(c2ccc(N)cc2)CC1
|
CSCCc1ccc(N)cc1
|
CSC1CCC(c2ccc(N)cc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C2C3"
}
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.