prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CCCCN1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)(C)N1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
|
CCCCN1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
|
CCCC(C)(C)N1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&(C)C",
"old_substring": "CCCC5"
}
|
Can you make molecule CCCCN1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCCC(=O)N1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
|
CCCCN1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
|
CCCCCCC(=O)N1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCCC&=O",
"old_substring": "CCCC5"
}
|
Can you make molecule CCCCN1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](C)N1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
|
CCCCN1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
|
CCCC[C@@H](C)N1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]&C",
"old_substring": "CCCC5"
}
|
Can you make molecule CCCCN1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC[C@@H](C)N1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
|
CCCCN1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
|
CCCCC[C@@H](C)N1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC[C@H]&C",
"old_substring": "CCCC5"
}
|
Can you make molecule CCCCN1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cccc2c1NC(=O)[C@]21N[C@@H](CCC(=O)[O-])[C@H]2C(=O)N(C(C)(CC)CC)C(=O)[C@H]21
|
CCCCN1C(=O)[C@@H]2[C@H](CCC(=O)[O-])N[C@]3(C(=O)Nc4c(CC)cccc43)[C@@H]2C1=O
|
CCc1cccc2c1NC(=O)[C@]21N[C@@H](CCC(=O)[O-])[C@H]2C(=O)N(C(C)(CC)CC)C(=O)[C@H]21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(C)CC",
"old_substring": "CCCC5"
}
|
Can you make molecule C/C(=N/NC(=O)[C@H]1C=C(C(C)C)N=N1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N/NC(=O)[C@H]1CCC=CCCC1)c1cccs1
|
C/C(=N/NC(=O)[C@H]1C=C(C(C)C)N=N1)c1cccs1
|
C/C(=N/NC(=O)[C@H]1CCC=CCCC1)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC=CCCC1",
"old_substring": "[C@H]12C=C(C(C)C)N=N1"
}
|
Can you make molecule C/C(=N/NC(=O)[C@H]1C=C(C(C)C)N=N1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N/NC(=O)[C@@H](C)CCC(C)(C)C)c1cccs1
|
C/C(=N/NC(=O)[C@H]1C=C(C(C)C)N=N1)c1cccs1
|
C/C(=N/NC(=O)[C@@H](C)CCC(C)(C)C)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(C)CCC(C)(C)C",
"old_substring": "[C@H]12C=C(C(C)C)N=N1"
}
|
Can you make molecule C/C(=N/NC(=O)[C@H]1C=C(C(C)C)N=N1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N/NC(=O)[C@H]1CCCC[C@@H]1I)c1cccs1
|
C/C(=N/NC(=O)[C@H]1C=C(C(C)C)N=N1)c1cccs1
|
C/C(=N/NC(=O)[C@H]1CCCC[C@@H]1I)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@@H]1I",
"old_substring": "[C@H]12C=C(C(C)C)N=N1"
}
|
Can you make molecule C/C(=N/NC(=O)[C@H]1C=C(C(C)C)N=N1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N/NC(=O)[C@H]1CC12CCCCC2)c1cccs1
|
C/C(=N/NC(=O)[C@H]1C=C(C(C)C)N=N1)c1cccs1
|
C/C(=N/NC(=O)[C@H]1CC12CCCCC2)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC12CCCCC2",
"old_substring": "[C@H]12C=C(C(C)C)N=N1"
}
|
Can you make molecule C/C(=N/NC(=O)[C@H]1C=C(C(C)C)N=N1)c1cccs1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N/NC(=O)[C@@]1(C)CC1(Br)Br)c1cccs1
|
C/C(=N/NC(=O)[C@H]1C=C(C(C)C)N=N1)c1cccs1
|
C/C(=N/NC(=O)[C@@]1(C)CC1(Br)Br)c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@]1&(C)CC1(Br)Br",
"old_substring": "[C@H]12C=C(C(C)C)N=N1"
}
|
Can you make molecule N[C@H]1C(=O)Nc2cc(SCc3ccccc3)c(Br)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
N[C@H]1C(=O)Nc2cc(SCSCc3ccccc3)c(Br)cc21
|
N[C@H]1C(=O)Nc2cc(SCc3ccccc3)c(Br)cc21
|
N[C@H]1C(=O)Nc2cc(SCSCc3ccccc3)c(Br)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "S&CS&",
"old_substring": "S46"
}
|
Can you make molecule N[C@H]1C(=O)Nc2cc(SCc3ccccc3)c(Br)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
N[C@H]1C(=O)Nc2cc(-c3ccc4c(c3)N(Cc3ccccc3)CCS4)c(Br)cc21
|
N[C@H]1C(=O)Nc2cc(SCc3ccccc3)c(Br)cc21
|
N[C@H]1C(=O)Nc2cc(-c3ccc4c(c3)N(Cc3ccccc3)CCS4)c(Br)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "S46"
}
|
Can you make molecule N[C@H]1C(=O)Nc2cc(SCc3ccccc3)c(Br)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
N#C/C(Nc1cc2c(cc1Br)[C@@H](N)C(=O)N2)=C(/Cl)SCc1ccccc1
|
N[C@H]1C(=O)Nc2cc(SCc3ccccc3)c(Br)cc21
|
N#C/C(Nc1cc2c(cc1Br)[C@@H](N)C(=O)N2)=C(/Cl)SCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&/C(Cl)=C(\\C#N)N&",
"old_substring": "S46"
}
|
Can you make molecule N[C@H]1C(=O)Nc2cc(SCc3ccccc3)c(Br)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
N[C@H]1C(=O)Nc2cc(-n3c(=S)n(Cc4ccccc4)c4ccccc43)c(Br)cc21
|
N[C@H]1C(=O)Nc2cc(SCc3ccccc3)c(Br)cc21
|
N[C@H]1C(=O)Nc2cc(-n3c(=S)n(Cc4ccccc4)c4ccccc43)c(Br)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&c(=S)n&c2ccccc21",
"old_substring": "S46"
}
|
Can you make molecule N[C@H]1C(=O)Nc2cc(SCc3ccccc3)c(Br)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](c1cc2c(cc1Br)[C@@H](N)C(=O)N2)[S@@+]([O-])CCCCc1ccccc1
|
N[C@H]1C(=O)Nc2cc(SCc3ccccc3)c(Br)cc21
|
C[C@@H](c1cc2c(cc1Br)[C@@H](N)C(=O)N2)[S@@+]([O-])CCCCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC[S@](=O)[C@H]&C",
"old_substring": "S46"
}
|
Can you make molecule CN(CCC(=O)NC(=O)Nc1ccccc1)Cc1ncnn1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1CN1CCC(CCC(=O)NC(=O)Nc2ccccc2)CC1
|
CN(CCC(=O)NC(=O)Nc1ccccc1)Cc1ncnn1C
|
Cn1ncnc1CN1CCC(CCC(=O)NC(=O)Nc2ccccc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCN&CC1",
"old_substring": "CN56"
}
|
Can you make molecule CN(CCC(=O)NC(=O)Nc1ccccc1)Cc1ncnn1C less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CCC(=O)NC(=O)Nc1ccccc1)C(=S)SCc1ncnn1C
|
CN(CCC(=O)NC(=O)Nc1ccccc1)Cc1ncnn1C
|
CN(CCC(=O)NC(=O)Nc1ccccc1)C(=S)SCc1ncnn1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "CN56"
}
|
Can you make molecule CN(CCC(=O)NC(=O)Nc1ccccc1)Cc1ncnn1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1CC1CCN(CCCC(=O)NC(=O)Nc2ccccc2)CC1
|
CN(CCC(=O)NC(=O)Nc1ccccc1)Cc1ncnn1C
|
Cn1ncnc1CC1CCN(CCCC(=O)NC(=O)Nc2ccccc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "CN56"
}
|
Can you make molecule CN(CCC(=O)NC(=O)Nc1ccccc1)Cc1ncnn1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1CN1CN(CCC(=O)NC(=O)Nc2ccccc2)CSC1=S
|
CN(CCC(=O)NC(=O)Nc1ccccc1)Cc1ncnn1C
|
Cn1ncnc1CN1CN(CCC(=O)NC(=O)Nc2ccccc2)CSC1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "S=C1SCN&CN1&",
"old_substring": "CN56"
}
|
Can you make molecule CN(CCC(=O)NC(=O)Nc1ccccc1)Cc1ncnn1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ncnc1CC1CCC(C#N)(CCC(=O)NC(=O)Nc2ccccc2)CC1
|
CN(CCC(=O)NC(=O)Nc1ccccc1)Cc1ncnn1C
|
Cn1ncnc1CC1CCC(C#N)(CCC(=O)NC(=O)Nc2ccccc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCC&CC1",
"old_substring": "CN56"
}
|
Can you make molecule Cc1cccc2ncnc(-n3cc([N+](=O)[O-])cn3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc2ncnc(-n3ccc(=O)n(C)c3=O)c12
|
Cc1cccc2ncnc(-n3cc([N+](=O)[O-])cn3)c12
|
Cc1cccc2ncnc(-n3ccc(=O)n(C)c3=O)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccc(=O)n(C)c1=O",
"old_substring": "n14cc([N+](=O)[O-])cn1"
}
|
Can you make molecule Cc1cccc2ncnc(-n3cc([N+](=O)[O-])cn3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(=O)nc(-c2ncnc3cccc(C)c23)[nH]1
|
Cc1cccc2ncnc(-n3cc([N+](=O)[O-])cn3)c12
|
Cc1cc(=O)nc(-c2ncnc3cccc(C)c23)[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc(=O)cc(C)[nH]1",
"old_substring": "n14cc([N+](=O)[O-])cn1"
}
|
Can you make molecule Cc1cccc2ncnc(-n3cc([N+](=O)[O-])cn3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc2ncnc(-n3c(C)c[nH]c3=O)c12
|
Cc1cccc2ncnc(-n3cc([N+](=O)[O-])cn3)c12
|
Cc1cccc2ncnc(-n3c(C)c[nH]c3=O)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c[nH]c(=O)n1&",
"old_substring": "n14cc([N+](=O)[O-])cn1"
}
|
Can you make molecule Cc1cccc2ncnc(-n3cc([N+](=O)[O-])cn3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)n1ccc(-c2ncnc3cccc(C)c23)n1
|
Cc1cccc2ncnc(-n3cc([N+](=O)[O-])cn3)c12
|
CC(=O)n1ccc(-c2ncnc3cccc(C)c23)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccn(C(C)=O)n1",
"old_substring": "n14cc([N+](=O)[O-])cn1"
}
|
Can you make molecule Cc1cccc2ncnc(-n3cc([N+](=O)[O-])cn3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc2ncnc(-n3ccc(=O)c(O)c3C)c12
|
Cc1cccc2ncnc(-n3cc([N+](=O)[O-])cn3)c12
|
Cc1cccc2ncnc(-n3ccc(=O)c(O)c3C)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c(O)c(=O)ccn1&",
"old_substring": "n14cc([N+](=O)[O-])cn1"
}
|
Can you make molecule C=CCCCN(C)C(=O)c1cc(-c2csc(C)n2)c[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCC[C@@H](N)C(=O)c1cc(-c2csc(C)n2)c[nH]1
|
C=CCCCN(C)C(=O)c1cc(-c2csc(C)n2)c[nH]1
|
C=CCCCCC[C@@H](N)C(=O)c1cc(-c2csc(C)n2)c[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "N[C@@H]&CC&",
"old_substring": "N34C"
}
|
Can you make molecule C=CCCCN(C)C(=O)c1cc(-c2csc(C)n2)c[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCC1=NCCN1C(=O)c1cc(-c2csc(C)n2)c[nH]1
|
C=CCCCN(C)C(=O)c1cc(-c2csc(C)n2)c[nH]1
|
C=CCCCCC1=NCCN1C(=O)c1cc(-c2csc(C)n2)c[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1C&",
"old_substring": "N34C"
}
|
Can you make molecule C=CCCCN(C)C(=O)c1cc(-c2csc(C)n2)c[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCc1sc(C(=O)c2cc(-c3csc(C)n3)c[nH]2)cc1C#N
|
C=CCCCN(C)C(=O)c1cc(-c2csc(C)n2)c[nH]1
|
C=CCCCc1sc(C(=O)c2cc(-c3csc(C)n3)c[nH]2)cc1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&sc1&",
"old_substring": "N34C"
}
|
Can you make molecule C=CCCCN(C)C(=O)c1cc(-c2csc(C)n2)c[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCc1ccc(C(=O)c2cc(-c3csc(C)n3)c[nH]2)cc1C#N
|
C=CCCCN(C)C(=O)c1cc(-c2csc(C)n2)c[nH]1
|
C=CCCCc1ccc(C(=O)c2cc(-c3csc(C)n3)c[nH]2)cc1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1cc&ccc1&",
"old_substring": "N34C"
}
|
Can you make molecule C=CCCCN(C)C(=O)c1cc(-c2csc(C)n2)c[nH]1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCN1CCC(=NOC(=O)c2cc(-c3csc(C)n3)c[nH]2)CC1
|
C=CCCCN(C)C(=O)c1cc(-c2csc(C)n2)c[nH]1
|
C=CCCCN1CCC(=NOC(=O)c2cc(-c3csc(C)n3)c[nH]2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "N34C"
}
|
Can you make molecule Cn1ccc(C(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ccc(CC(=O)SN(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
|
Cn1ccc(C(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
|
Cn1ccc(CC(=O)SN(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule Cn1ccc(C(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ccc(C(=O)CCCC(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
|
Cn1ccc(C(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
|
Cn1ccc(C(=O)CCCC(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
}
|
Can you make molecule Cn1ccc(C(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ccc(C(C)(C)CC(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
|
Cn1ccc(C(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
|
Cn1ccc(C(C)(C)CC(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule Cn1ccc(C(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1ccc(C(C)(C)CCC(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
|
Cn1ccc(C(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
|
Cn1ccc(C(C)(C)CCC(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule Cn1ccc(C(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SN(C[C@@H]1CCCO1)c1nc2ccccc2s1)c1ccn(C)n1
|
Cn1ccc(C(=O)N(C[C@@H]2CCCO2)c2nc3ccccc3s2)n1
|
C[C@H](C(=O)SN(C[C@@H]1CCCO1)c1nc2ccccc2s1)c1ccn(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1ccc(NC(=O)CSc2ncccc2C#N)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2snc(C(=O)CSc3ncccc3C#N)c2N)cc1C
|
Cc1ccc(NC(=O)CSc2ncccc2C#N)cc1C
|
Cc1ccc(-c2snc(C(=O)CSc3ncccc3C#N)c2N)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&nsc1&",
"old_substring": "N35"
}
|
Can you make molecule Cc1ccc(NC(=O)CSc2ncccc2C#N)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(SC(=S)N(C)C(=O)CSc2ncccc2C#N)cc1C
|
Cc1ccc(NC(=O)CSc2ncccc2C#N)cc1C
|
Cc1ccc(SC(=S)N(C)C(=O)CSc2ncccc2C#N)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N35"
}
|
Can you make molecule Cc1ccc(NC(=O)CSc2ncccc2C#N)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(-c2cc(C(=O)CSc3ncccc3C#N)oc2N)cc1C
|
Cc1ccc(NC(=O)CSc2ncccc2C#N)cc1C
|
Cc1ccc(-c2cc(C(=O)CSc3ncccc3C#N)oc2N)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1oc&cc1&",
"old_substring": "N35"
}
|
Can you make molecule Cc1ccc(NC(=O)CSc2ncccc2C#N)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(SC2=NCCN2C(=O)CSc2ncccc2C#N)cc1C
|
Cc1ccc(NC(=O)CSc2ncccc2C#N)cc1C
|
Cc1ccc(SC2=NCCN2C(=O)CSc2ncccc2C#N)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N35"
}
|
Can you make molecule Cc1ccc(NC(=O)CSc2ncccc2C#N)cc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C2CCN(CC(=O)CSc3ncccc3C#N)CC2)cc1C
|
Cc1ccc(NC(=O)CSc2ncccc2C#N)cc1C
|
Cc1ccc(C2CCN(CC(=O)CSc3ncccc3C#N)CC2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N35"
}
|
Can you make molecule Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CCS(=O)(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
|
Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
|
Cc1ccc(CCS(=O)(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CS(=O)(=O)[O-]",
"old_substring": "C6(=O)[O-]"
}
|
Can you make molecule Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(=O)CO)cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
|
Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
|
Cc1ccc(C(=O)CO)cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CO",
"old_substring": "C6(=O)[O-]"
}
|
Can you make molecule Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(O)O)cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
|
Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
|
Cc1ccc(C(O)O)cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(O)O",
"old_substring": "C6(=O)[O-]"
}
|
Can you make molecule Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)[O-])c1ccc(C)c(NC(=O)c2ccc(-c3cccc([N+](=O)[O-])c3)o2)c1
|
Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
|
CCC(CC)(C(=O)[O-])c1ccc(C)c(NC(=O)c2ccc(-c3cccc([N+](=O)[O-])c3)o2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)[O-]",
"old_substring": "C6(=O)[O-]"
}
|
Can you make molecule Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CCCS(=O)(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
|
Cc1ccc(C(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
|
Cc1ccc(CCCS(=O)(=O)[O-])cc1NC(=O)c1ccc(-c2cccc([N+](=O)[O-])c2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCS(=O)(=O)[O-]",
"old_substring": "C6(=O)[O-]"
}
|
Can you make molecule COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)no2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCCCC4)cc3)no2)c1
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)no2)c1
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCCCC4)cc3)no2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCC1",
"old_substring": "N18CCCC1"
}
|
Can you make molecule COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)no2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCCCCC4)cc3)no2)c1
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)no2)c1
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCCCCC4)cc3)no2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCC1",
"old_substring": "N18CCCC1"
}
|
Can you make molecule COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)no2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCC(C)CC4)cc3)no2)c1
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)no2)c1
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCC(C)CC4)cc3)no2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC(C)CC1",
"old_substring": "N18CCCC1"
}
|
Can you make molecule COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)no2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCCCCCC4)cc3)no2)c1
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)no2)c1
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCCCCCC4)cc3)no2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCCC1",
"old_substring": "N18CCCC1"
}
|
Can you make molecule COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)no2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCCCCC4=O)cc3)no2)c1
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCC4)cc3)no2)c1
|
COc1cccc(-c2cc(CNC(=O)c3ccc(S(=O)(=O)N4CCCCCCC4=O)cc3)no2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCC1=O",
"old_substring": "N18CCCC1"
}
|
Can you make molecule O=c1[nH]c(=O)n(C[C@@H]2CCCO2)c2nccc(-c3ccccc3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1[nH]c(=O)n(C[C@@H]2CCSC2)c2nccc(-c3ccccc3)c12
|
O=c1[nH]c(=O)n(C[C@@H]2CCCO2)c2nccc(-c3ccccc3)c12
|
O=c1[nH]c(=O)n(C[C@@H]2CCSC2)c2nccc(-c3ccccc3)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCSC1",
"old_substring": "[C@@H]15CCCO1"
}
|
Can you make molecule O=c1[nH]c(=O)n(C[C@@H]2CCCO2)c2nccc(-c3ccccc3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1[nH]c(=O)n(C[C@@H]2C=CCC2)c2nccc(-c3ccccc3)c12
|
O=c1[nH]c(=O)n(C[C@@H]2CCCO2)c2nccc(-c3ccccc3)c12
|
O=c1[nH]c(=O)n(C[C@@H]2C=CCC2)c2nccc(-c3ccccc3)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&C=CCC1",
"old_substring": "[C@@H]15CCCO1"
}
|
Can you make molecule O=c1[nH]c(=O)n(C[C@@H]2CCCO2)c2nccc(-c3ccccc3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1[nH]c(=O)n(C[C@@H]2CCCSC2)c2nccc(-c3ccccc3)c12
|
O=c1[nH]c(=O)n(C[C@@H]2CCCO2)c2nccc(-c3ccccc3)c12
|
O=c1[nH]c(=O)n(C[C@@H]2CCCSC2)c2nccc(-c3ccccc3)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCSC1",
"old_substring": "[C@@H]15CCCO1"
}
|
Can you make molecule O=c1[nH]c(=O)n(C[C@@H]2CCCO2)c2nccc(-c3ccccc3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1[nH]c(=O)n(C[C@H]2CCCOCC2)c2nccc(-c3ccccc3)c12
|
O=c1[nH]c(=O)n(C[C@@H]2CCCO2)c2nccc(-c3ccccc3)c12
|
O=c1[nH]c(=O)n(C[C@H]2CCCOCC2)c2nccc(-c3ccccc3)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCOCC1",
"old_substring": "[C@@H]15CCCO1"
}
|
Can you make molecule O=c1[nH]c(=O)n(C[C@@H]2CCCO2)c2nccc(-c3ccccc3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1OCCC[C@H]1Cn1c(=O)[nH]c(=O)c2c(-c3ccccc3)ccnc21
|
O=c1[nH]c(=O)n(C[C@@H]2CCCO2)c2nccc(-c3ccccc3)c12
|
C[C@@H]1OCCC[C@H]1Cn1c(=O)[nH]c(=O)c2c(-c3ccccc3)ccnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCO[C@H]1C",
"old_substring": "[C@@H]15CCCO1"
}
|
Can you make molecule CCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
|
CCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
|
C=CSc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC4"
}
|
Can you make molecule CCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
|
CCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
|
CC(C)c1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC4"
}
|
Can you make molecule CCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
|
CCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
|
C=CCCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC4"
}
|
Can you make molecule CCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1c(CCCCl)nn(C)c1Cl)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
|
CCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
|
CN(Cc1c(CCCCl)nn(C)c1Cl)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC4"
}
|
Can you make molecule CCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1c(CCCCS)nn(C)c1Cl)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
|
CCc1nn(C)c(Cl)c1CN(C)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
|
CN(Cc1c(CCCCS)nn(C)c1Cl)[C@@H]1CCCC[C@@H]1S(C)(=O)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC4"
}
|
Can you make molecule Cn1c(CC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(CCC(CO)=Nc2cccc(Cl)c2Cl)n[nH]c1=S
|
Cn1c(CC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S
|
Cn1c(CCC(CO)=Nc2cccc(Cl)c2Cl)n[nH]c1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C5C3=O"
}
|
Can you make molecule Cn1c(CC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(Cc1n[nH]c(=S)n1C)=N/ONc1cccc(Cl)c1Cl
|
Cn1c(CC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S
|
C/C(Cc1n[nH]c(=S)n1C)=N/ONc1cccc(Cl)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C5C3=O"
}
|
Can you make molecule Cn1c(CC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CNc1cccc(Cl)c1Cl)c1n[nH]c(=S)n1C
|
Cn1c(CC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S
|
CCC(CC)(C(=O)CNc1cccc(Cl)c1Cl)c1n[nH]c(=S)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C5C3=O"
}
|
Can you make molecule Cn1c(CC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1c(SSC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S
|
Cn1c(CC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S
|
Cn1c(SSC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C5C3=O"
}
|
Can you make molecule Cn1c(CC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CCNc1cccc(Cl)c1Cl)c1n[nH]c(=S)n1C
|
Cn1c(CC(=O)Nc2cccc(Cl)c2Cl)n[nH]c1=S
|
CCC(CC)(C(=O)CCNc1cccc(Cl)c1Cl)c1n[nH]c(=S)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C5C3=O"
}
|
Can you make molecule O=C1c2ccccc2O[C@@H](c2ccccc2)N1CCO less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1c2ccccc2O[C@@H](c2ccccc2Cl)N1CCO
|
O=C1c2ccccc2O[C@@H](c2ccccc2)N1CCO
|
O=C1c2ccccc2O[C@@H](c2ccccc2Cl)N1CCO
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c14ccccc1"
}
|
Can you make molecule O=C1c2ccccc2O[C@@H](c2ccccc2)N1CCO less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1c2ccccc2O[C@@H](c2ccc(I)cc2)N1CCO
|
O=C1c2ccccc2O[C@@H](c2ccccc2)N1CCO
|
O=C1c2ccccc2O[C@@H](c2ccc(I)cc2)N1CCO
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c14ccccc1"
}
|
Can you make molecule O=C1c2ccccc2O[C@@H](c2ccccc2)N1CCO less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc([C@@H]2Oc3ccccc3C(=O)N2CCO)cc1I
|
O=C1c2ccccc2O[C@@H](c2ccccc2)N1CCO
|
Cc1ccc([C@@H]2Oc3ccccc3C(=O)N2CCO)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c14ccccc1"
}
|
Can you make molecule O=C1c2ccccc2O[C@@H](c2ccccc2)N1CCO less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1c2ccccc2O[C@@H](c2cccc(Br)c2)N1CCO
|
O=C1c2ccccc2O[C@@H](c2ccccc2)N1CCO
|
O=C1c2ccccc2O[C@@H](c2cccc(Br)c2)N1CCO
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c14ccccc1"
}
|
Can you make molecule O=C1c2ccccc2O[C@@H](c2ccccc2)N1CCO less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@@H]2Oc3ccccc3C(=O)N2CCO)c1C
|
O=C1c2ccccc2O[C@@H](c2ccccc2)N1CCO
|
Cc1cccc([C@@H]2Oc3ccccc3C(=O)N2CCO)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c14ccccc1"
}
|
Can you make molecule Cc1nnc(SCC(=O)Nc2cccc(F)c2)n1-n1cccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnc(SCSCC(=O)Nc2cccc(F)c2)n1-n1cccc1
|
Cc1nnc(SCC(=O)Nc2cccc(F)c2)n1-n1cccc1
|
Cc1nnc(SCSCC(=O)Nc2cccc(F)c2)n1-n1cccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&CS&",
"old_substring": "S46"
}
|
Can you make molecule Cc1nnc(SCC(=O)Nc2cccc(F)c2)n1-n1cccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnc(-c2ccc3c(c2)N(CC(=O)Nc2cccc(F)c2)CCS3)n1-n1cccc1
|
Cc1nnc(SCC(=O)Nc2cccc(F)c2)n1-n1cccc1
|
Cc1nnc(-c2ccc3c(c2)N(CC(=O)Nc2cccc(F)c2)CCS3)n1-n1cccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "S46"
}
|
Can you make molecule Cc1nnc(SCC(=O)Nc2cccc(F)c2)n1-n1cccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnc(C(Cl)(Cl)[S@+]([O-])CCC(=O)Nc2cccc(F)c2)n1-n1cccc1
|
Cc1nnc(SCC(=O)Nc2cccc(F)c2)n1-n1cccc1
|
Cc1nnc(C(Cl)(Cl)[S@+]([O-])CCC(=O)Nc2cccc(F)c2)n1-n1cccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=[S@](C&)C&(Cl)Cl",
"old_substring": "S46"
}
|
Can you make molecule Cc1nnc(SCC(=O)Nc2cccc(F)c2)n1-n1cccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnc(N/C(C#N)=C(\Cl)SCC(=O)Nc2cccc(F)c2)n1-n1cccc1
|
Cc1nnc(SCC(=O)Nc2cccc(F)c2)n1-n1cccc1
|
Cc1nnc(N/C(C#N)=C(\Cl)SCC(=O)Nc2cccc(F)c2)n1-n1cccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&/C(Cl)=C(\\C#N)N&",
"old_substring": "S46"
}
|
Can you make molecule Cc1nnc(SCC(=O)Nc2cccc(F)c2)n1-n1cccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnc(-n2c(=S)n(CC(=O)Nc3cccc(F)c3)c3ccccc32)n1-n1cccc1
|
Cc1nnc(SCC(=O)Nc2cccc(F)c2)n1-n1cccc1
|
Cc1nnc(-n2c(=S)n(CC(=O)Nc3cccc(F)c3)c3ccccc32)n1-n1cccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&c(=S)n&c2ccccc21",
"old_substring": "S46"
}
|
Can you make molecule C[C@H]1CCN(C(=O)NCc2cscn2)[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCN(C(=O)NCSCc2cscn2)[C@H](C)C1
|
C[C@H]1CCN(C(=O)NCc2cscn2)[C@H](C)C1
|
C[C@H]1CCN(C(=O)NCSCc2cscn2)[C@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&CS&",
"old_substring": "N45"
}
|
Can you make molecule C[C@H]1CCN(C(=O)NCc2cscn2)[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCN(C(=O)NC(=N)SCc2cscn2)[C@H](C)C1
|
C[C@H]1CCN(C(=O)NCc2cscn2)[C@H](C)C1
|
C[C@H]1CCN(C(=O)NC(=N)SCc2cscn2)[C@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N&C(=N)S&",
"old_substring": "N45"
}
|
Can you make molecule C[C@H]1CCN(C(=O)NCc2cscn2)[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCN(C(=O)N(C)C(=S)SCc2cscn2)[C@H](C)C1
|
C[C@H]1CCN(C(=O)NCc2cscn2)[C@H](C)C1
|
C[C@H]1CCN(C(=O)N(C)C(=S)SCc2cscn2)[C@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N45"
}
|
Can you make molecule C[C@H]1CCN(C(=O)NCc2cscn2)[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCN(C(=O)N2CCN=C2SCc2cscn2)[C@H](C)C1
|
C[C@H]1CCN(C(=O)NCc2cscn2)[C@H](C)C1
|
C[C@H]1CCN(C(=O)N2CCN=C2SCc2cscn2)[C@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N45"
}
|
Can you make molecule C[C@H]1CCN(C(=O)NCc2cscn2)[C@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCN(C(=O)CN2CCC(Cc3cscn3)CC2)[C@H](C)C1
|
C[C@H]1CCN(C(=O)NCc2cscn2)[C@H](C)C1
|
C[C@H]1CCN(C(=O)CN2CCC(Cc3cscn3)CC2)[C@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N45"
}
|
Can you make molecule CCOC(=O)c1sc(NC)nc1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSOC(=O)c1sc(NC)nc1C(F)(F)F
|
CCOC(=O)c1sc(NC)nc1C(F)(F)F
|
C=CSOC(=O)c1sc(NC)nc1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC3"
}
|
Can you make molecule CCOC(=O)c1sc(NC)nc1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCOC(=O)c1sc(NC)nc1C(F)(F)F
|
CCOC(=O)c1sc(NC)nc1C(F)(F)F
|
C=CCCOC(=O)c1sc(NC)nc1C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CCOC(=O)c1sc(NC)nc1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1nc(C(F)(F)F)c(C(=O)OCCCCl)s1
|
CCOC(=O)c1sc(NC)nc1C(F)(F)F
|
CNc1nc(C(F)(F)F)c(C(=O)OCCCCl)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CCOC(=O)c1sc(NC)nc1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1nc(C(F)(F)F)c(C(=O)OCCCCS)s1
|
CCOC(=O)c1sc(NC)nc1C(F)(F)F
|
CNc1nc(C(F)(F)F)c(C(=O)OCCCCS)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule CCOC(=O)c1sc(NC)nc1C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1nc(C(F)(F)F)c(C(=O)OCCCBr)s1
|
CCOC(=O)c1sc(NC)nc1C(F)(F)F
|
CNc1nc(C(F)(F)F)c(C(=O)OCCCBr)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC3"
}
|
Can you make molecule O=C(Cc1ccccc1F)NNC(=O)c1c[nH]c2cccc(F)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cc1ccccc1F)C(=O)c1c[nH]c2cccc(F)c12
|
O=C(Cc1ccccc1F)NNC(=O)c1c[nH]c2cccc(F)c12
|
O=C(Cc1ccccc1F)C(=O)c1c[nH]c2cccc(F)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(C&)C&=O",
"old_substring": "O=C(C4)NNC3=O"
}
|
Can you make molecule O=C(Cc1ccccc1F)NNC(=O)c1c[nH]c2cccc(F)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cc1ccccc1F)N/N=C/Cc1c[nH]c2cccc(F)c12
|
O=C(Cc1ccccc1F)NNC(=O)c1c[nH]c2cccc(F)c12
|
O=C(Cc1ccccc1F)N/N=C/Cc1c[nH]c2cccc(F)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(C&)N/N=C/C&",
"old_substring": "O=C(C4)NNC3=O"
}
|
Can you make molecule O=C(Cc1ccccc1F)NNC(=O)c1c[nH]c2cccc(F)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCc1ccccc1F)NOc1c[nH]c2cccc(F)c12
|
O=C(Cc1ccccc1F)NNC(=O)c1c[nH]c2cccc(F)c12
|
O=C(CCCc1ccccc1F)NOc1c[nH]c2cccc(F)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(CCC&)NO&",
"old_substring": "O=C(C4)NNC3=O"
}
|
Can you make molecule O=C(Cc1ccccc1F)NNC(=O)c1c[nH]c2cccc(F)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cc1ccccc1F)N/N=C/CCc1c[nH]c2cccc(F)c12
|
O=C(Cc1ccccc1F)NNC(=O)c1c[nH]c2cccc(F)c12
|
O=C(Cc1ccccc1F)N/N=C/CCc1c[nH]c2cccc(F)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C(C&)N/N=C/CC&",
"old_substring": "O=C(C4)NNC3=O"
}
|
Can you make molecule O=C(Cc1ccccc1F)NNC(=O)c1c[nH]c2cccc(F)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCC(=O)c1c[nH]c2cccc(F)c12)c1ccccc1F
|
O=C(Cc1ccccc1F)NNC(=O)c1c[nH]c2cccc(F)c12
|
O=C(CCC(=O)c1c[nH]c2cccc(F)c12)c1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&CCC&=O",
"old_substring": "O=C(C4)NNC3=O"
}
|
Can you make molecule Cc1ccccc1CSC1=NS(=O)(=O)c2ccccc2N1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CSC2=NS(=O)(=O)c3ccccc3N2)cc1I
|
Cc1ccccc1CSC1=NS(=O)(=O)c2ccccc2N1
|
Cc1ccc(CSC2=NS(=O)(=O)c3ccccc3N2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "Cc1ccccc14"
}
|
Can you make molecule Cc1ccccc1CSC1=NS(=O)(=O)c2ccccc2N1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CSC2=NS(=O)(=O)c3ccccc3N2)cc1Cl
|
Cc1ccccc1CSC1=NS(=O)(=O)c2ccccc2N1
|
Cc1ccc(CSC2=NS(=O)(=O)c3ccccc3N2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1Cl",
"old_substring": "Cc1ccccc14"
}
|
Can you make molecule Cc1ccccc1CSC1=NS(=O)(=O)c2ccccc2N1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(I)ccc1CSC1=NS(=O)(=O)c2ccccc2N1
|
Cc1ccccc1CSC1=NS(=O)(=O)c2ccccc2N1
|
Cc1cc(I)ccc1CSC1=NS(=O)(=O)c2ccccc2N1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(I)ccc1&",
"old_substring": "Cc1ccccc14"
}
|
Can you make molecule Cc1ccccc1CSC1=NS(=O)(=O)c2ccccc2N1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(I)c(CSC2=NS(=O)(=O)c3ccccc3N2)c1
|
Cc1ccccc1CSC1=NS(=O)(=O)c2ccccc2N1
|
Cc1ccc(I)c(CSC2=NS(=O)(=O)c3ccccc3N2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(I)c&c1",
"old_substring": "Cc1ccccc14"
}
|
Can you make molecule Cc1ccccc1CSC1=NS(=O)(=O)c2ccccc2N1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Br)c(CSC2=NS(=O)(=O)c3ccccc3N2)c1
|
Cc1ccccc1CSC1=NS(=O)(=O)c2ccccc2N1
|
Cc1ccc(Br)c(CSC2=NS(=O)(=O)c3ccccc3N2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(Br)c&c1",
"old_substring": "Cc1ccccc14"
}
|
Can you make molecule Cc1cc(C(=O)CSc2nnc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)CSc2nn(-c3ccccc3)c(=S)n2C)c(C)n1C[C@H]1CCCO1
|
Cc1cc(C(=O)CSc2nnc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1
|
Cc1cc(C(=O)CSc2nn(-c3ccccc3)c(=S)n2C)c(C)n1C[C@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nn&c(=S)n1C",
"old_substring": "c18nnc9n1C"
}
|
Can you make molecule Cc1cc(C(=O)CSc2nnc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)CSc2nnc(-c3ccccc3)s2)c(C)n1C[C@H]1CCCO1
|
Cc1cc(C(=O)CSc2nnc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1
|
Cc1cc(C(=O)CSc2nnc(-c3ccccc3)s2)c(C)n1C[C@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nnc&s1",
"old_substring": "c18nnc9n1C"
}
|
Can you make molecule Cc1cc(C(=O)CSc2nnc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)CSc2ncc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1
|
Cc1cc(C(=O)CSc2nnc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1
|
Cc1cc(C(=O)CSc2ncc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc&n1C",
"old_substring": "c18nnc9n1C"
}
|
Can you make molecule Cc1cc(C(=O)CSc2nnc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)CSc2cc(-c3ccccc3)nn2C)c(C)n1C[C@H]1CCCO1
|
Cc1cc(C(=O)CSc2nnc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1
|
Cc1cc(C(=O)CSc2cc(-c3ccccc3)nn2C)c(C)n1C[C@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&nn1C",
"old_substring": "c18nnc9n1C"
}
|
Can you make molecule Cc1cc(C(=O)CSc2nnc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C(=O)CSc2n[nH]c(=S)n2NCc2ccccc2)c(C)n1C[C@H]1CCCO1
|
Cc1cc(C(=O)CSc2nnc(-c3ccccc3)n2C)c(C)n1C[C@H]1CCCO1
|
Cc1cc(C(=O)CSc2n[nH]c(=S)n2NCc2ccccc2)c(C)n1C[C@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&n[nH]c(=S)n1NC&",
"old_substring": "c18nnc9n1C"
}
|
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