prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule O=C([C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C2=CC=CC2=C(N(CC(F)(F)F)c2ccccc2)CCN1[C@H]1CCOC1
|
O=C([C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1
|
O=C1C2=CC=CC2=C(N(CC(F)(F)F)c2ccccc2)CCN1[C@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1c2cccc&c2CCN1&",
"old_substring": "O=C25"
}
|
Can you make molecule O=C([C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1c(N(CC(F)(F)F)c2ccccc2)cc([C@H]2CCOC2)ccc2oc1-2
|
O=C([C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1
|
O=Cc1c(N(CC(F)(F)F)c2ccccc2)cc([C@H]2CCOC2)ccc2oc1-2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1c&oc2ccc&cc12",
"old_substring": "O=C25"
}
|
Can you make molecule O=C([C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/S[C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1
|
O=C([C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1
|
O=C(/C=C/S[C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C25"
}
|
Can you make molecule O=C([C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(N(CC(F)(F)F)c2ccccc2)nc1[C@H]1CCOC1
|
O=C([C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1
|
O=Cc1sc(N(CC(F)(F)F)c2ccccc2)nc1[C@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C25"
}
|
Can you make molecule O=C([C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(N(CC(F)(F)F)c2ccccc2)sc1[C@H]1CCOC1
|
O=C([C@H]1CCOC1)N(CC(F)(F)F)c1ccccc1
|
O=Cc1nc(N(CC(F)(F)F)c2ccccc2)sc1[C@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C25"
}
|
Can you make molecule Cc1nc(CN(CC(=O)N(C)C)c2ccccc2)oc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CN2CCC(CC(=O)N(C)C)(c3ccccc3)C2)oc1C
|
Cc1nc(CN(CC(=O)N(C)C)c2ccccc2)oc1C
|
Cc1nc(CN2CCC(CC(=O)N(C)C)(c3ccccc3)C2)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N456"
}
|
Can you make molecule Cc1nc(CN(CC(=O)N(C)C)c2ccccc2)oc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CN2CCCC(CC(=O)N(C)C)(c3ccccc3)C2)oc1C
|
Cc1nc(CN(CC(=O)N(C)C)c2ccccc2)oc1C
|
Cc1nc(CN2CCCC(CC(=O)N(C)C)(c3ccccc3)C2)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N456"
}
|
Can you make molecule Cc1nc(CN(CC(=O)N(C)C)c2ccccc2)oc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(Cc2oc(CC(=O)N(C)C)c(-c3ccccc3)c2C#N)oc1C
|
Cc1nc(CN(CC(=O)N(C)C)c2ccccc2)oc1C
|
Cc1nc(Cc2oc(CC(=O)N(C)C)c(-c3ccccc3)c2C#N)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N456"
}
|
Can you make molecule Cc1nc(CN(CC(=O)N(C)C)c2ccccc2)oc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CN2CC(CC(=O)N(C)C)(c3ccccc3)CCC2=O)oc1C
|
Cc1nc(CN(CC(=O)N(C)C)c2ccccc2)oc1C
|
Cc1nc(CN2CC(CC(=O)N(C)C)(c3ccccc3)CCC2=O)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC&&CCC1=O",
"old_substring": "N456"
}
|
Can you make molecule Cc1nc(CN(CC(=O)N(C)C)c2ccccc2)oc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CN2CCC[C@@](CC(=O)N(C)C)(c3ccccc3)C2)oc1C
|
Cc1nc(CN(CC(=O)N(C)C)c2ccccc2)oc1C
|
Cc1nc(CN2CCC[C@@](CC(=O)N(C)C)(c3ccccc3)C2)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC[C@@]&&C1",
"old_substring": "N456"
}
|
Can you make molecule COCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21
|
COCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21
|
COCCCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C3C6"
}
|
Can you make molecule COCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21
|
COCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21
|
COCCCCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C3C6"
}
|
Can you make molecule COCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1CC(n2/c(=N\C(=O)[C@H]3CCCCN3S(C)(=O)=O)sc3c(C)cc(C)cc32)C1
|
COCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21
|
COC1CC(n2/c(=N\C(=O)[C@H]3CCCCN3S(C)(=O)=O)sc3c(C)cc(C)cc32)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C3C6"
}
|
Can you make molecule COCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@@H](C)CCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21
|
COCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21
|
CO[C@@H](C)CCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C3C6"
}
|
Can you make molecule COCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1CCC(n2/c(=N\C(=O)[C@H]3CCCCN3S(C)(=O)=O)sc3c(C)cc(C)cc32)CC1
|
COCCn1/c(=N\C(=O)[C@H]2CCCCN2S(C)(=O)=O)sc2c(C)cc(C)cc21
|
COC1CCC(n2/c(=N\C(=O)[C@H]3CCCCN3S(C)(=O)=O)sc3c(C)cc(C)cc32)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C3C6"
}
|
Can you make molecule Cc1nn(C)cc1[C@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)cc1CCC[C@@H](CCl)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
|
Cc1nn(C)cc1[C@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
|
Cc1nn(C)cc1CCC[C@@H](CCl)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]58C"
}
|
Can you make molecule Cc1nn(C)cc1[C@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)cc1CCC1=CN=N[C@H]1NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
|
Cc1nn(C)cc1[C@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
|
Cc1nn(C)cc1CCC1=CN=N[C@H]1NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N=NC=C1CC&",
"old_substring": "[C@@H]58C"
}
|
Can you make molecule Cc1nn(C)cc1[C@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)cc1[C@@H]1CC[C@@H](NC(=O)Nc2ncn(Cc3ccc(C#N)cc3)n2)C1
|
Cc1nn(C)cc1[C@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
|
Cc1nn(C)cc1[C@@H]1CC[C@@H](NC(=O)Nc2ncn(Cc3ccc(C#N)cc3)n2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]58C"
}
|
Can you make molecule Cc1nn(C)cc1[C@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(C)cc1CC(C)(C)[C@@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
|
Cc1nn(C)cc1[C@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
|
Cc1nn(C)cc1CC(C)(C)[C@@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(C)C(C)(C)C&",
"old_substring": "[C@@H]58C"
}
|
Can you make molecule Cc1nn(C)cc1[C@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1cn(C)nc1C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
|
Cc1nn(C)cc1[C@H](C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
|
CC[C@@H](CCc1cn(C)nc1C)NC(=O)Nc1ncn(Cc2ccc(C#N)cc2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@@H]58C"
}
|
Can you make molecule COc1ccc(C[C@@H](C)C(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CC[C@H](C)CC(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
|
COc1ccc(C[C@@H](C)C(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
|
COc1ccc(CC[C@H](C)CC(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C6[C@@H](C)C4=O"
}
|
Can you make molecule COc1ccc(C[C@@H](C)C(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CC[C@@H](C)CC(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
|
COc1ccc(C[C@@H](C)C(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
|
COc1ccc(CC[C@@H](C)CC(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "C6[C@@H](C)C4=O"
}
|
Can you make molecule COc1ccc(C[C@@H](C)C(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C[C@@H](Cl)CCN2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
|
COc1ccc(C[C@@H](C)C(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
|
COc1ccc(C[C@@H](Cl)CCN2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cl[C@H](C&)CC&",
"old_substring": "C6[C@@H](C)C4=O"
}
|
Can you make molecule COc1ccc(C[C@@H](C)C(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc([C@H](C)CC(C)(C)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
|
COc1ccc(C[C@@H](C)C(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
|
COc1ccc([C@H](C)CC(C)(C)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C6[C@@H](C)C4=O"
}
|
Can you make molecule COc1ccc(C[C@@H](C)C(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc([C@@H](C)CCN2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
|
COc1ccc(C[C@@H](C)C(=O)N2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
|
COc1ccc([C@@H](C)CCN2c3ccc([N+](=O)[O-])cc3C[C@H]2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C6[C@@H](C)C4=O"
}
|
Can you make molecule Cc1cnc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(CC(=O)SNc2ccc(OC(F)(F)F)cc2)cn1
|
Cc1cnc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cn1
|
Cc1cnc(CC(=O)SNc2ccc(OC(F)(F)F)cc2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1cnc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(C(=O)CCCC(=O)Nc2ccc(OC(F)(F)F)cc2)cn1
|
Cc1cnc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cn1
|
Cc1cnc(C(=O)CCCC(=O)Nc2ccc(OC(F)(F)F)cc2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1cnc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(C(C)(C)CC(=O)Nc2ccc(OC(F)(F)F)cc2)cn1
|
Cc1cnc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cn1
|
Cc1cnc(C(C)(C)CC(=O)Nc2ccc(OC(F)(F)F)cc2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1cnc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc(C(C)(C)CCC(=O)Nc2ccc(OC(F)(F)F)cc2)cn1
|
Cc1cnc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cn1
|
Cc1cnc(C(C)(C)CCC(=O)Nc2ccc(OC(F)(F)F)cc2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C36=O"
}
|
Can you make molecule Cc1cnc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cnc([C@H](C)C(=O)SNc2ccc(OC(F)(F)F)cc2)cn1
|
Cc1cnc(C(=O)Nc2ccc(OC(F)(F)F)cc2)cn1
|
Cc1cnc([C@H](C)C(=O)SNc2ccc(OC(F)(F)F)cc2)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C36=O"
}
|
Can you make molecule Cn1cc(S(=O)(=O)N2CCN(C(=O)c3ccccc3O)CC2)cc1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(S(=O)(=O)N2CCN(SC(=O)Cc3ccccc3O)CC2)cc1C(N)=O
|
Cn1cc(S(=O)(=O)N2CCN(C(=O)c3ccccc3O)CC2)cc1C(N)=O
|
Cn1cc(S(=O)(=O)N2CCN(SC(=O)Cc3ccccc3O)CC2)cc1C(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule Cn1cc(S(=O)(=O)N2CCN(C(=O)c3ccccc3O)CC2)cc1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(S(=O)(=O)N2CCN(C(=O)CCCC(=O)c3ccccc3O)CC2)cc1C(N)=O
|
Cn1cc(S(=O)(=O)N2CCN(C(=O)c3ccccc3O)CC2)cc1C(N)=O
|
Cn1cc(S(=O)(=O)N2CCN(C(=O)CCCC(=O)c3ccccc3O)CC2)cc1C(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
}
|
Can you make molecule Cn1cc(S(=O)(=O)N2CCN(C(=O)c3ccccc3O)CC2)cc1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(S(=O)(=O)N2CCN(C(=O)CC(C)(C)c3ccccc3O)CC2)cc1C(N)=O
|
Cn1cc(S(=O)(=O)N2CCN(C(=O)c3ccccc3O)CC2)cc1C(N)=O
|
Cn1cc(S(=O)(=O)N2CCN(C(=O)CC(C)(C)c3ccccc3O)CC2)cc1C(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule Cn1cc(S(=O)(=O)N2CCN(C(=O)c3ccccc3O)CC2)cc1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(S(=O)(=O)N2CCN(C(=O)CCC(C)(C)c3ccccc3O)CC2)cc1C(N)=O
|
Cn1cc(S(=O)(=O)N2CCN(C(=O)c3ccccc3O)CC2)cc1C(N)=O
|
Cn1cc(S(=O)(=O)N2CCN(C(=O)CCC(C)(C)c3ccccc3O)CC2)cc1C(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule Cn1cc(S(=O)(=O)N2CCN(C(=O)c3ccccc3O)CC2)cc1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SN1CCN(S(=O)(=O)c2cc(C(N)=O)n(C)c2)CC1)c1ccccc1O
|
Cn1cc(S(=O)(=O)N2CCN(C(=O)c3ccccc3O)CC2)cc1C(N)=O
|
C[C@H](C(=O)SN1CCN(S(=O)(=O)c2cc(C(N)=O)n(C)c2)CC1)c1ccccc1O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C47=O"
}
|
Can you make molecule CO[C@]1(C)C[C@H](NC(=O)NCc2ccnc(OCC(F)F)c2)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@]1(C)C[C@H](NC(=O)CC(C)(C)NCc2ccnc(OCC(F)F)c2)C1(C)C
|
CO[C@]1(C)C[C@H](NC(=O)NCc2ccnc(OCC(F)F)c2)C1(C)C
|
CO[C@]1(C)C[C@H](NC(=O)CC(C)(C)NCc2ccnc(OCC(F)F)c2)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CO[C@]1(C)C[C@H](NC(=O)NCc2ccnc(OCC(F)F)c2)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@]1(C)C[C@H](NC(=O)CCC(C)(C)NCc2ccnc(OCC(F)F)c2)C1(C)C
|
CO[C@]1(C)C[C@H](NC(=O)NCc2ccnc(OCC(F)F)c2)C1(C)C
|
CO[C@]1(C)C[C@H](NC(=O)CCC(C)(C)NCc2ccnc(OCC(F)F)c2)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule CO[C@]1(C)C[C@H](NC(=O)NCc2ccnc(OCC(F)F)c2)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@]1(C)C[C@H](Nc2c(C)n(C)n(NCc3ccnc(OCC(F)F)c3)c2=O)C1(C)C
|
CO[C@]1(C)C[C@H](NC(=O)NCc2ccnc(OCC(F)F)c2)C1(C)C
|
CO[C@]1(C)C[C@H](Nc2c(C)n(C)n(NCc3ccnc(OCC(F)F)c3)c2=O)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)n&n1C",
"old_substring": "C34=O"
}
|
Can you make molecule CO[C@]1(C)C[C@H](NC(=O)NCc2ccnc(OCC(F)F)c2)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@]1(C)C[C@H](Nc2nn(NCc3ccnc(OCC(F)F)c3)c(C)cc2=O)C1(C)C
|
CO[C@]1(C)C[C@H](NC(=O)NCc2ccnc(OCC(F)F)c2)C1(C)C
|
CO[C@]1(C)C[C@H](Nc2nn(NCc3ccnc(OCC(F)F)c3)c(C)cc2=O)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(=O)c&nn1&",
"old_substring": "C34=O"
}
|
Can you make molecule CO[C@]1(C)C[C@H](NC(=O)NCc2ccnc(OCC(F)F)c2)C1(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@]1(C)C[C@H](NC(=O)C[C@@H](Br)NCc2ccnc(OCC(F)F)c2)C1(C)C
|
CO[C@]1(C)C[C@H](NC(=O)NCc2ccnc(OCC(F)F)c2)C1(C)C
|
CO[C@]1(C)C[C@H](NC(=O)C[C@@H](Br)NCc2ccnc(OCC(F)F)c2)C1(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C34=O"
}
|
Can you make molecule CCc1ccc(-c2csc(NC(=O)[C@H]3CCC(=O)NC3)n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(-c2csc(NSC(=O)C[C@H]3CCC(=O)NC3)n2)cc1
|
CCc1ccc(-c2csc(NC(=O)[C@H]3CCC(=O)NC3)n2)cc1
|
CCc1ccc(-c2csc(NSC(=O)C[C@H]3CCC(=O)NC3)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule CCc1ccc(-c2csc(NC(=O)[C@H]3CCC(=O)NC3)n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(-c2csc(NCC(=C=O)C[C@H]3CCC(=O)NC3)n2)cc1
|
CCc1ccc(-c2csc(NC(=O)[C@H]3CCC(=O)NC3)n2)cc1
|
CCc1ccc(-c2csc(NCC(=C=O)C[C@H]3CCC(=O)NC3)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C46=O"
}
|
Can you make molecule CCc1ccc(-c2csc(NC(=O)[C@H]3CCC(=O)NC3)n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(-c2csc(NC(=O)CCCC(=O)[C@H]3CCC(=O)NC3)n2)cc1
|
CCc1ccc(-c2csc(NC(=O)[C@H]3CCC(=O)NC3)n2)cc1
|
CCc1ccc(-c2csc(NC(=O)CCCC(=O)[C@H]3CCC(=O)NC3)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C46=O"
}
|
Can you make molecule CCc1ccc(-c2csc(NC(=O)[C@H]3CCC(=O)NC3)n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(-c2csc(NC(=O)CC(C)(C)[C@H]3CCC(=O)NC3)n2)cc1
|
CCc1ccc(-c2csc(NC(=O)[C@H]3CCC(=O)NC3)n2)cc1
|
CCc1ccc(-c2csc(NC(=O)CC(C)(C)[C@H]3CCC(=O)NC3)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C46=O"
}
|
Can you make molecule CCc1ccc(-c2csc(NC(=O)[C@H]3CCC(=O)NC3)n2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1ccc(-c2csc(NC[S@+]([O-])CCC[C@H]3CCC(=O)NC3)n2)cc1
|
CCc1ccc(-c2csc(NC(=O)[C@H]3CCC(=O)NC3)n2)cc1
|
CCc1ccc(-c2csc(NC[S@+]([O-])CCC[C@H]3CCC(=O)NC3)n2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C46=O"
}
|
Can you make molecule COC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
COSC(=O)Cc1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
|
COC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
|
COSC(=O)Cc1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C34=O"
}
|
Can you make molecule COC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CCCC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
|
COC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
|
COC(=O)CCCC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C34=O"
}
|
Can you make molecule COC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CC(C)(C)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
|
COC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
|
COC(=O)CC(C)(C)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule COC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)CCC(C)(C)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
|
COC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
|
COC(=O)CCC(C)(C)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C34=O"
}
|
Can you make molecule COC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12 less soluble in water? The output molecule should be similar to the input molecule.
|
COSC(=O)[C@@H](C)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
|
COC(=O)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
|
COSC(=O)[C@@H](C)c1nc2ccc(F)cc2c2oc(C(C)(C)O)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C34=O"
}
|
Can you make molecule CCCCn1c(=O)c2sccc2n2c(=O)n(C)nc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)(C)n1c(=O)c2sccc2n2c(=O)n(C)nc12
|
CCCCn1c(=O)c2sccc2n2c(=O)n(C)nc12
|
CCCC(C)(C)n1c(=O)c2sccc2n2c(=O)n(C)nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&(C)C",
"old_substring": "CCCC3"
}
|
Can you make molecule CCCCn1c(=O)c2sccc2n2c(=O)n(C)nc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCCC(=O)n1c(=O)c2sccc2n2c(=O)n(C)nc12
|
CCCCn1c(=O)c2sccc2n2c(=O)n(C)nc12
|
CCCCCCC(=O)n1c(=O)c2sccc2n2c(=O)n(C)nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCCC&=O",
"old_substring": "CCCC3"
}
|
Can you make molecule CCCCn1c(=O)c2sccc2n2c(=O)n(C)nc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](C)n1c(=O)c2sccc2n2c(=O)n(C)nc12
|
CCCCn1c(=O)c2sccc2n2c(=O)n(C)nc12
|
CCCC[C@@H](C)n1c(=O)c2sccc2n2c(=O)n(C)nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]&C",
"old_substring": "CCCC3"
}
|
Can you make molecule CCCCn1c(=O)c2sccc2n2c(=O)n(C)nc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC[C@@H](C)n1c(=O)c2sccc2n2c(=O)n(C)nc12
|
CCCCn1c(=O)c2sccc2n2c(=O)n(C)nc12
|
CCCCC[C@@H](C)n1c(=O)c2sccc2n2c(=O)n(C)nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC[C@H]&C",
"old_substring": "CCCC3"
}
|
Can you make molecule CCCCn1c(=O)c2sccc2n2c(=O)n(C)nc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(CC)n1c(=O)c2sccc2n2c(=O)n(C)nc12
|
CCCCn1c(=O)c2sccc2n2c(=O)n(C)nc12
|
CCC(C)(CC)n1c(=O)c2sccc2n2c(=O)n(C)nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(C)CC",
"old_substring": "CCCC3"
}
|
Can you make molecule Cc1ccc(C[NH+](CC(=O)N2C[C@@H](C)C[C@H](C)C2)C(C)C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C[NH+]2CCC(CC(=O)N3C[C@@H](C)C[C@H](C)C3)(C(C)C)C2)s1
|
Cc1ccc(C[NH+](CC(=O)N2C[C@@H](C)C[C@H](C)C2)C(C)C)s1
|
Cc1ccc(C[NH+]2CCC(CC(=O)N3C[C@@H](C)C[C@H](C)C3)(C(C)C)C2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC&&C1",
"old_substring": "[NH+]456"
}
|
Can you make molecule Cc1ccc(C[NH+](CC(=O)N2C[C@@H](C)C[C@H](C)C2)C(C)C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C[NH+]2CCC[C@](CC(=O)N3C[C@@H](C)C[C@H](C)C3)(C(C)C)C2)s1
|
Cc1ccc(C[NH+](CC(=O)N2C[C@@H](C)C[C@H](C)C2)C(C)C)s1
|
Cc1ccc(C[NH+]2CCC[C@](CC(=O)N3C[C@@H](C)C[C@H](C)C3)(C(C)C)C2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC[C@]&&C1",
"old_substring": "[NH+]456"
}
|
Can you make molecule Cc1ccc(C[NH+](CC(=O)N2C[C@@H](C)C[C@H](C)C2)C(C)C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Cc2[nH+]cn(CC(=O)N3C[C@@H](C)C[C@H](C)C3)c2C(C)C)s1
|
Cc1ccc(C[NH+](CC(=O)N2C[C@@H](C)C[C@H](C)C2)C(C)C)s1
|
Cc1ccc(Cc2[nH+]cn(CC(=O)N3C[C@@H](C)C[C@H](C)C3)c2C(C)C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&[nH+]cn&c1&",
"old_substring": "[NH+]456"
}
|
Can you make molecule Cc1ccc(C[NH+](CC(=O)N2C[C@@H](C)C[C@H](C)C2)C(C)C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Cn2[nH+]c(CC(=O)N3C[C@@H](C)C[C@H](C)C3)cc2C(C)C)s1
|
Cc1ccc(C[NH+](CC(=O)N2C[C@@H](C)C[C@H](C)C2)C(C)C)s1
|
Cc1ccc(Cn2[nH+]c(CC(=O)N3C[C@@H](C)C[C@H](C)C3)cc2C(C)C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&[nH+]c&cc1&",
"old_substring": "[NH+]456"
}
|
Can you make molecule Cc1ccc(C[NH+](CC(=O)N2C[C@@H](C)C[C@H](C)C2)C(C)C)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Cc2[nH+]n(C)c(CC(=O)N3C[C@@H](C)C[C@H](C)C3)c2C(C)C)s1
|
Cc1ccc(C[NH+](CC(=O)N2C[C@@H](C)C[C@H](C)C2)C(C)C)s1
|
Cc1ccc(Cc2[nH+]n(C)c(CC(=O)N3C[C@@H](C)C[C@H](C)C3)c2C(C)C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&[nH+]n(C)c&c1&",
"old_substring": "[NH+]456"
}
|
Can you make molecule Cc1ccc(NC(=O)N2CCN(c3ccc(F)cn3)CC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)CC(C)(C)N2CCN(c3ccc(F)cn3)CC2)s1
|
Cc1ccc(NC(=O)N2CCN(c3ccc(F)cn3)CC2)s1
|
Cc1ccc(NC(=O)CC(C)(C)N2CCN(c3ccc(F)cn3)CC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule Cc1ccc(NC(=O)N2CCN(c3ccc(F)cn3)CC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)CCC(C)(C)N2CCN(c3ccc(F)cn3)CC2)s1
|
Cc1ccc(NC(=O)N2CCN(c3ccc(F)cn3)CC2)s1
|
Cc1ccc(NC(=O)CCC(C)(C)N2CCN(c3ccc(F)cn3)CC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C45=O"
}
|
Can you make molecule Cc1ccc(NC(=O)N2CCN(c3ccc(F)cn3)CC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)C[C@@H](Br)N2CCN(c3ccc(F)cn3)CC2)s1
|
Cc1ccc(NC(=O)N2CCN(c3ccc(F)cn3)CC2)s1
|
Cc1ccc(NC(=O)C[C@@H](Br)N2CCN(c3ccc(F)cn3)CC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C45=O"
}
|
Can you make molecule Cc1ccc(NC(=O)N2CCN(c3ccc(F)cn3)CC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Nc2cc(C)n(N3CCN(c4ccc(F)cn4)CC3)c(=O)c2)s1
|
Cc1ccc(NC(=O)N2CCN(c3ccc(F)cn3)CC2)s1
|
Cc1ccc(Nc2cc(C)n(N3CCN(c4ccc(F)cn4)CC3)c(=O)c2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(=O)n1&",
"old_substring": "C45=O"
}
|
Can you make molecule Cc1ccc(NC(=O)N2CCN(c3ccc(F)cn3)CC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Nc2c(C)n(N3CCN(c4ccc(F)cn4)CC3)ccc2=O)s1
|
Cc1ccc(NC(=O)N2CCN(c3ccc(F)cn3)CC2)s1
|
Cc1ccc(Nc2c(C)n(N3CCN(c4ccc(F)cn4)CC3)ccc2=O)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)ccn1&",
"old_substring": "C45=O"
}
|
Can you make molecule CCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1
|
CCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1
|
CC(C)CCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC5"
}
|
Can you make molecule CCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1c2ccccc2N[C@@H](c2ccccc2OC[C@@H]2CCCO2)N1CCCCBr
|
CCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1
|
O=C1c2ccccc2N[C@@H](c2ccccc2OC[C@@H]2CCCO2)N1CCCCBr
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC5"
}
|
Can you make molecule CCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1
|
CCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1
|
C=CCCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC5"
}
|
Can you make molecule CCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1c2ccccc2N[C@@H](c2ccccc2OC[C@@H]2CCCO2)N1CCCCCl
|
CCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1
|
O=C1c2ccccc2N[C@@H](c2ccccc2OC[C@@H]2CCCO2)N1CCCCCl
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC5"
}
|
Can you make molecule CCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1
|
CCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1
|
C=CCCCCN1C(=O)c2ccccc2N[C@H]1c1ccccc1OC[C@@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CCC5"
}
|
Can you make molecule O[C@H](CNc1ncnc2sc3c(c12)CCNC3)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O[C@H](CCCNc1ncnc2sc3c(c12)CCNC3)c1ccccc1
|
O[C@H](CNc1ncnc2sc3c(c12)CCNC3)c1ccccc1
|
O[C@H](CCCNc1ncnc2sc3c(c12)CCNC3)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@@H]&CCC&",
"old_substring": "O[C@@H]6C4"
}
|
Can you make molecule O[C@H](CNc1ncnc2sc3c(c12)CCNC3)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
c1ccc([C@@H]2CCN(Nc3ncnc4sc5c(c34)CCNC5)C2)cc1
|
O[C@H](CNc1ncnc2sc3c(c12)CCNC3)c1ccccc1
|
c1ccc([C@@H]2CCN(Nc3ncnc4sc5c(c34)CCNC5)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCN&C1",
"old_substring": "O[C@@H]6C4"
}
|
Can you make molecule O[C@H](CNc1ncnc2sc3c(c12)CCNC3)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
c1ccc([C@@H]2CN(Nc3ncnc4sc5c(c34)CCNC5)CCS2)cc1
|
O[C@H](CNc1ncnc2sc3c(c12)CCNC3)c1ccccc1
|
c1ccc([C@@H]2CN(Nc3ncnc4sc5c(c34)CCNC5)CCS2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CN&CCS1",
"old_substring": "O[C@@H]6C4"
}
|
Can you make molecule O[C@H](CNc1ncnc2sc3c(c12)CCNC3)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
c1ccc([C@@H]2CCCN(Nc3ncnc4sc5c(c34)CCNC5)CC2)cc1
|
O[C@H](CNc1ncnc2sc3c(c12)CCNC3)c1ccccc1
|
c1ccc([C@@H]2CCCN(Nc3ncnc4sc5c(c34)CCNC5)CC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCN&CC1",
"old_substring": "O[C@@H]6C4"
}
|
Can you make molecule O[C@H](CNc1ncnc2sc3c(c12)CCNC3)c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
ClC[C@H](CCCNc1ncnc2sc3c(c12)CCNC3)c1ccccc1
|
O[C@H](CNc1ncnc2sc3c(c12)CCNC3)c1ccccc1
|
ClC[C@H](CCCNc1ncnc2sc3c(c12)CCNC3)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "O[C@@H]6C4"
}
|
Can you make molecule Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCO2)c(=O)c1C#N less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCOCC2)c(=O)c1C#N
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCO2)c(=O)c1C#N
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCOCC2)c(=O)c1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCOCC1",
"old_substring": "[C@H]17CCCO1"
}
|
Can you make molecule Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCO2)c(=O)c1C#N less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CSCCS2)c(=O)c1C#N
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCO2)c(=O)c1C#N
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CSCCS2)c(=O)c1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CSCCS1",
"old_substring": "[C@H]17CCCO1"
}
|
Can you make molecule Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCO2)c(=O)c1C#N less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CC=CS2)c(=O)c1C#N
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCO2)c(=O)c1C#N
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CC=CS2)c(=O)c1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC=CS1",
"old_substring": "[C@H]17CCCO1"
}
|
Can you make molecule Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCO2)c(=O)c1C#N less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@@H]2CCSC2)c(=O)c1C#N
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCO2)c(=O)c1C#N
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@@H]2CCSC2)c(=O)c1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCSC1",
"old_substring": "[C@H]17CCCO1"
}
|
Can you make molecule Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCO2)c(=O)c1C#N less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CC23CCOCC3)c(=O)c1C#N
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CCCO2)c(=O)c1C#N
|
Cc1c(C(=O)[C@H](C)Oc2ccccc2Cl)c([O-])n(C[C@H]2CC23CCOCC3)c(=O)c1C#N
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC12CCOCC2",
"old_substring": "[C@H]17CCCO1"
}
|
Can you make molecule CCC[NH2+]CC[NH+](C)CC(C)(C)O less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH+]1CC[NH2+]CCC(CC(C)(C)O)CC1
|
CCC[NH2+]CC[NH+](C)CC(C)(C)O
|
CCC[NH+]1CC[NH2+]CCC(CC(C)(C)O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC&CC1",
"old_substring": "[NH+]34C"
}
|
Can you make molecule CCC[NH2+]CC[NH+](C)CC(C)(C)O less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH2+]CCC[NH+](C)CCC(C)(C)O
|
CCC[NH2+]CC[NH+](C)CC(C)(C)O
|
CCC[NH2+]CCC[NH+](C)CCC(C)(C)O
| 102
|
{
"fragment_index": 0,
"new_substring": "C[NH+](C&)C&",
"old_substring": "[NH+]34C"
}
|
Can you make molecule CCC[NH2+]CC[NH+](C)CC(C)(C)O less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH+]1CCC[NH2+]CCC(CC(C)(C)O)CC1
|
CCC[NH2+]CC[NH+](C)CC(C)(C)O
|
CCC[NH+]1CCC[NH2+]CCC(CC(C)(C)O)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&CC1",
"old_substring": "[NH+]34C"
}
|
Can you make molecule CCC[NH2+]CC[NH+](C)CC(C)(C)O less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH+]1CC=C(CCC(C)(C)O)CC[NH2+]CC1
|
CCC[NH2+]CC[NH+](C)CC(C)(C)O
|
CCC[NH+]1CC=C(CCC(C)(C)O)CC[NH2+]CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC=C(C&)CC1",
"old_substring": "[NH+]34C"
}
|
Can you make molecule CCC[NH2+]CC[NH+](C)CC(C)(C)O less soluble in water? The output molecule should be similar to the input molecule.
|
CCC[NH+]1CCC[C@H](CC(C)(C)O)CC[NH2+]CC1
|
CCC[NH2+]CC[NH+](C)CC(C)(C)O
|
CCC[NH+]1CCC[C@H](CC(C)(C)O)CC[NH2+]CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC[C@H]&CC1",
"old_substring": "[NH+]34C"
}
|
Can you make molecule C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3)CC2)nn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3I)CC2)nn1
|
C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3)CC2)nn1
|
C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3I)CC2)nn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccccc1I",
"old_substring": "C=7c1ccccc1"
}
|
Can you make molecule C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3)CC2)nn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3Br)CC2)nn1
|
C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3)CC2)nn1
|
C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3Br)CC2)nn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccccc1Br",
"old_substring": "C=7c1ccccc1"
}
|
Can you make molecule C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3)CC2)nn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3Cl)CC2)nn1
|
C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3)CC2)nn1
|
C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3Cl)CC2)nn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccccc1Cl",
"old_substring": "C=7c1ccccc1"
}
|
Can you make molecule C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3)CC2)nn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=CC(=O)N1CCN(c2ccc(N3CCCC[C@H]3C)nn2)CC1)c1ccccc1F
|
C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3)CC2)nn1
|
CC(=CC(=O)N1CCN(c2ccc(N3CCCC[C@H]3C)nn2)CC1)c1ccccc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&c1ccccc1F",
"old_substring": "C=7c1ccccc1"
}
|
Can you make molecule C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3)CC2)nn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=CC(=O)N1CCN(c2ccc(N3CCCC[C@H]3C)nn2)CC1)c1ccccc1
|
C[C@@H]1CCCCN1c1ccc(N2CCN(C(=O)C=Cc3ccccc3)CC2)nn1
|
CCC(=CC(=O)N1CCN(c2ccc(N3CCCC[C@H]3C)nn2)CC1)c1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&c1ccccc1",
"old_substring": "C=7c1ccccc1"
}
|
Can you make molecule CC(C)[C@@H](Sc1nnc(C(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](Sc1nnc(C(Cl)(Cl)Cl)o1)C(=O)Nc1ccc(Cl)cc1
|
CC(C)[C@@H](Sc1nnc(C(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1
|
CC(C)[C@@H](Sc1nnc(C(Cl)(Cl)Cl)o1)C(=O)Nc1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(Cl)(Cl)Cl",
"old_substring": "C5(C)(C)C"
}
|
Can you make molecule CC(C)[C@@H](Sc1nnc(C(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](Sc1nnc(C(C)(C)CC(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1
|
CC(C)[C@@H](Sc1nnc(C(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1
|
CC(C)[C@@H](Sc1nnc(C(C)(C)CC(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)(C)CC(C)(C)C",
"old_substring": "C5(C)(C)C"
}
|
Can you make molecule CC(C)[C@@H](Sc1nnc(C(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](Sc1nnc(CCCC(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1
|
CC(C)[C@@H](Sc1nnc(C(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1
|
CC(C)[C@@H](Sc1nnc(CCCC(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(C)(C)C",
"old_substring": "C5(C)(C)C"
}
|
Can you make molecule CC(C)[C@@H](Sc1nnc(C(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](Sc1nnc(CCCC(F)(F)F)o1)C(=O)Nc1ccc(Cl)cc1
|
CC(C)[C@@H](Sc1nnc(C(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1
|
CC(C)[C@@H](Sc1nnc(CCCC(F)(F)F)o1)C(=O)Nc1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C5(C)(C)C"
}
|
Can you make molecule CC(C)[C@@H](Sc1nnc(C(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@@H](Sc1nnc(CCCCC(F)(F)F)o1)C(=O)Nc1ccc(Cl)cc1
|
CC(C)[C@@H](Sc1nnc(C(C)(C)C)o1)C(=O)Nc1ccc(Cl)cc1
|
CC(C)[C@@H](Sc1nnc(CCCCC(F)(F)F)o1)C(=O)Nc1ccc(Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C5(C)(C)C"
}
|
Can you make molecule COc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1
|
COc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1
|
COCc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO5"
}
|
Can you make molecule COc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1
|
COc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1
|
COCSc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO5"
}
|
Can you make molecule COc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1
|
COc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1
|
CC(=O)Sc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO5"
}
|
Can you make molecule COc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnnn1C(=Cc1cccc(C(=O)CS)c1)C(=O)OC1CCCCC1
|
COc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1
|
Cc1nnnn1C(=Cc1cccc(C(=O)CS)c1)C(=O)OC1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO5"
}
|
Can you make molecule COc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnnn1C(=Cc1cccc(C(=O)CI)c1)C(=O)OC1CCCCC1
|
COc1cccc(C=C(C(=O)OC2CCCCC2)n2nnnc2C)c1
|
Cc1nnnn1C(=Cc1cccc(C(=O)CI)c1)C(=O)OC1CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO5"
}
|
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