prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]CC(=O)N1CCc2sccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(C[NH2+][C@H](C)CC(=O)Nc1ccccc1C)=N/ON1CCc2sccc2C1
|
Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]CC(=O)N1CCc2sccc2C1
|
C/C(C[NH2+][C@H](C)CC(=O)Nc1ccccc1C)=N/ON1CCc2sccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C6C4=O"
}
|
Can you make molecule Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]CC(=O)N1CCc2sccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)([NH2+][C@H](C)CC(=O)Nc1ccccc1C)C(=O)CN1CCc2sccc2C1
|
Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]CC(=O)N1CCc2sccc2C1
|
CCC(CC)([NH2+][C@H](C)CC(=O)Nc1ccccc1C)C(=O)CN1CCc2sccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C6C4=O"
}
|
Can you make molecule Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]CC(=O)N1CCc2sccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]SSC(=O)N1CCc2sccc2C1
|
Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]CC(=O)N1CCc2sccc2C1
|
Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]SSC(=O)N1CCc2sccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C6C4=O"
}
|
Can you make molecule Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]CC(=O)N1CCc2sccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)([NH2+][C@H](C)CC(=O)Nc1ccccc1C)C(=O)CCN1CCc2sccc2C1
|
Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]CC(=O)N1CCc2sccc2C1
|
CCC(CC)([NH2+][C@H](C)CC(=O)Nc1ccccc1C)C(=O)CCN1CCc2sccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C6C4=O"
}
|
Can you make molecule Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]CC(=O)N1CCc2sccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C(=O)[NH2+][C@H](C)CC(=O)Nc1ccccc1C)C(=O)N1CCc2sccc2C1
|
Cc1ccccc1NC(=O)C[C@@H](C)[NH2+]CC(=O)N1CCc2sccc2C1
|
CC[C@H](C(=O)[NH2+][C@H](C)CC(=O)Nc1ccccc1C)C(=O)N1CCc2sccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H](C&=O)C&=O",
"old_substring": "C6C4=O"
}
|
Can you make molecule CC[C@@]1(C)NC(=S)N(c2ccccc2)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCC[C@@]1(C)NC(=S)N(c2ccccc2)N1
|
CC[C@@]1(C)NC(=S)N(c2ccccc2)N1
|
C=CCC[C@@]1(C)NC(=S)N(c2ccccc2)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@@]1(C)NC(=S)N(c2ccccc2)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@]1(CCCCl)NC(=S)N(c2ccccc2)N1
|
CC[C@@]1(C)NC(=S)N(c2ccccc2)N1
|
C[C@]1(CCCCl)NC(=S)N(c2ccccc2)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@@]1(C)NC(=S)N(c2ccccc2)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@]1(CCCCS)NC(=S)N(c2ccccc2)N1
|
CC[C@@]1(C)NC(=S)N(c2ccccc2)N1
|
C[C@]1(CCCCS)NC(=S)N(c2ccccc2)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@@]1(C)NC(=S)N(c2ccccc2)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@]1(CCCBr)NC(=S)N(c2ccccc2)N1
|
CC[C@@]1(C)NC(=S)N(c2ccccc2)N1
|
C[C@]1(CCCBr)NC(=S)N(c2ccccc2)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCBr",
"old_substring": "CC3"
}
|
Can you make molecule CC[C@@]1(C)NC(=S)N(c2ccccc2)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@]1(CCCCF)NC(=S)N(c2ccccc2)N1
|
CC[C@@]1(C)NC(=S)N(c2ccccc2)N1
|
C[C@]1(CCCCF)NC(=S)N(c2ccccc2)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCF",
"old_substring": "CC3"
}
|
Can you make molecule Clc1cccc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Clc1cccc(Cl)c1-n1ncc2c(Nc3ccc4c(c3)OCCO4)ncnc21
|
Clc1cccc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1
|
Clc1cccc(Cl)c1-n1ncc2c(Nc3ccc4c(c3)OCCO4)ncnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1cccc(Cl)c1&",
"old_substring": "Clc1cccc8c1"
}
|
Can you make molecule Clc1cccc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Clc1ccc(Cl)c(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1
|
Clc1cccc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1
|
Clc1ccc(Cl)c(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1ccc(Cl)c&c1",
"old_substring": "Clc1cccc8c1"
}
|
Can you make molecule Clc1cccc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Clc1ccc2c(-n3ncc4c(Nc5ccc6c(c5)OCCO6)ncnc43)ccnc2c1Cl
|
Clc1cccc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1
|
Clc1ccc2c(-n3ncc4c(Nc5ccc6c(c5)OCCO6)ncnc43)ccnc2c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Clc1ccc2c&ccnc2c1Cl",
"old_substring": "Clc1cccc8c1"
}
|
Can you make molecule Clc1cccc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c(C)cc1Br
|
Clc1cccc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1
|
Cc1cc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c(C)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&c(C)cc1Br",
"old_substring": "Clc1cccc8c1"
}
|
Can you make molecule Clc1cccc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)cc(C)c1Cl
|
Clc1cccc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)c1
|
Cc1cc(-n2ncc3c(Nc4ccc5c(c4)OCCO5)ncnc32)cc(C)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(C)c1Cl",
"old_substring": "Clc1cccc8c1"
}
|
Can you make molecule O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sc1csc2c1CCCC2)NCc1ccc(N2CCOCC2)[nH+]c1
|
O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2
|
O=C(/C=C/Sc1csc2c1CCCC2)NCc1ccc(N2CCOCC2)[nH+]c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C36"
}
|
Can you make molecule O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1sc(NCc2ccc(N3CCOCC3)[nH+]c2)nc1-c1csc2c1CCCC2
|
O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2
|
O=Cc1sc(NCc2ccc(N3CCOCC3)[nH+]c2)nc1-c1csc2c1CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1sc&nc1&",
"old_substring": "O=C36"
}
|
Can you make molecule O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=Cc1nc(NCc2ccc(N3CCOCC3)[nH+]c2)sc1-c1csc2c1CCCC2
|
O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2
|
O=Cc1nc(NCc2ccc(N3CCOCC3)[nH+]c2)sc1-c1csc2c1CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "O=Cc1nc&sc1&",
"old_substring": "O=C36"
}
|
Can you make molecule O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCc1ccc(N2CCOCC2)[nH+]c1)n1nc(-c2csc3c2CCCC3)oc1=S
|
O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2
|
O=C(NCc1ccc(N2CCOCC2)[nH+]c1)n1nc(-c2csc3c2CCCC3)oc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&n1nc&oc1=S",
"old_substring": "O=C36"
}
|
Can you make molecule O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
C(=N/ONCc1ccc(N2CCOCC2)[nH+]c1)\c1ccc(-c2csc3c2CCCC3)o1
|
O=C(NCc1ccc(N2CCOCC2)[nH+]c1)c1csc2c1CCCC2
|
C(=N/ONCc1ccc(N2CCOCC2)[nH+]c1)\c1ccc(-c2csc3c2CCCC3)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C36"
}
|
Can you make molecule CCC(C)(C)C(=O)NC[C@H](c1cccs1)[NH+]1CCC(C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(C)C(=O)NC1C[C@@H](c2cccs2)C[C@@H]([NH+]2CCC(C)CC2)C1
|
CCC(C)(C)C(=O)NC[C@H](c1cccs1)[NH+]1CCC(C)CC1
|
CCC(C)(C)C(=O)NC1C[C@@H](c2cccs2)C[C@@H]([NH+]2CCC(C)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&C[C@H]&C[C@H]&C1",
"old_substring": "C3[C@@H]45"
}
|
Can you make molecule CCC(C)(C)C(=O)NC[C@H](c1cccs1)[NH+]1CCC(C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(C)C(=O)N[C@H]1CC[C@@](c2cccs2)([NH+]2CCC(C)CC2)C1
|
CCC(C)(C)C(=O)NC[C@H](c1cccs1)[NH+]1CCC(C)CC1
|
CCC(C)(C)C(=O)N[C@H]1CC[C@@](c2cccs2)([NH+]2CCC(C)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@]&&C1",
"old_substring": "C3[C@@H]45"
}
|
Can you make molecule CCC(C)(C)C(=O)NC[C@H](c1cccs1)[NH+]1CCC(C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(C)C(=O)N[C@H]1CC[C@](c2cccs2)([NH+]2CCC(C)CC2)C1
|
CCC(C)(C)C(=O)NC[C@H](c1cccs1)[NH+]1CCC(C)CC1
|
CCC(C)(C)C(=O)N[C@H]1CC[C@](c2cccs2)([NH+]2CCC(C)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@@]&&C1",
"old_substring": "C3[C@@H]45"
}
|
Can you make molecule CCC(C)(C)C(=O)NC[C@H](c1cccs1)[NH+]1CCC(C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(C)C(=O)Nc1c(C)[nH]c([NH+]2CCC(C)CC2)c1-c1cccs1
|
CCC(C)(C)C(=O)NC[C@H](c1cccs1)[NH+]1CCC(C)CC1
|
CCC(C)(C)C(=O)Nc1c(C)[nH]c([NH+]2CCC(C)CC2)c1-c1cccs1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(C)[nH]c&c1&",
"old_substring": "C3[C@@H]45"
}
|
Can you make molecule CCC(C)(C)C(=O)NC[C@H](c1cccs1)[NH+]1CCC(C)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(C)C(=O)N[C@@H]1CCC[C@@](c2cccs2)([NH+]2CCC(C)CC2)C1
|
CCC(C)(C)C(=O)NC[C@H](c1cccs1)[NH+]1CCC(C)CC1
|
CCC(C)(C)C(=O)N[C@@H]1CCC[C@@](c2cccs2)([NH+]2CCC(C)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCC[C@]&&C1",
"old_substring": "C3[C@@H]45"
}
|
Can you make molecule O=C(COc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/SOc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1
|
O=C(COc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1
|
O=C(/C=C/SOc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(COc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(NON=C2CCN(Oc3ccc4ccccc4c3)CC2)cc1Cl)c1ccco1
|
O=C(COc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1
|
O=C(Nc1ccc(NON=C2CCN(Oc3ccc4ccccc4c3)CC2)cc1Cl)c1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(COc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCN(Oc2ccc3ccccc3c2)CC1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1
|
O=C(COc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1
|
O=C(NN=C1CCN(Oc2ccc3ccccc3c2)CC1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCN&CC1",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(COc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(Oc2ccc3ccccc3c2)CC1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1
|
O=C(COc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1
|
O=C(NN=C1CCC(Oc2ccc3ccccc3c2)CC1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(COc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\ONc1ccc(NC(=O)c2ccco2)c(Cl)c1)C(=O)SOc1ccc2ccccc2c1
|
O=C(COc1ccc2ccccc2c1)Nc1ccc(NC(=O)c2ccco2)c(Cl)c1
|
C/C(=N\ONc1ccc(NC(=O)c2ccco2)c(Cl)c1)C(=O)SOc1ccc2ccccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)C(=O)S&",
"old_substring": "O=C3C5"
}
|
Can you make molecule O=C(C[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/S[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl
|
O=C(C[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl
|
O=C(/C=C/S[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C2C3"
}
|
Can you make molecule O=C(C[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Clc1ccc(NON=C2CCN([NH+](Cc3ccco3)Cc3ccco3)CC2)c(Cl)c1
|
O=C(C[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl
|
Clc1ccc(NON=C2CCN([NH+](Cc3ccco3)Cc3ccco3)CC2)c(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&N=C1CCN&CC1",
"old_substring": "O=C2C3"
}
|
Can you make molecule O=C(C[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCN([NH+](Cc2ccco2)Cc2ccco2)CC1)Nc1ccc(Cl)cc1Cl
|
O=C(C[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl
|
O=C(NN=C1CCN([NH+](Cc2ccco2)Cc2ccco2)CC1)Nc1ccc(Cl)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCN&CC1",
"old_substring": "O=C2C3"
}
|
Can you make molecule O=C(C[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC([NH+](Cc2ccco2)Cc2ccco2)CC1)Nc1ccc(Cl)cc1Cl
|
O=C(C[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl
|
O=C(NN=C1CCC([NH+](Cc2ccco2)Cc2ccco2)CC1)Nc1ccc(Cl)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C2C3"
}
|
Can you make molecule O=C(C[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\ONc1ccc(Cl)cc1Cl)C(=O)S[NH+](Cc1ccco1)Cc1ccco1
|
O=C(C[NH+](Cc1ccco1)Cc1ccco1)Nc1ccc(Cl)cc1Cl
|
C/C(=N\ONc1ccc(Cl)cc1Cl)C(=O)S[NH+](Cc1ccco1)Cc1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)C(=O)S&",
"old_substring": "O=C2C3"
}
|
Can you make molecule CN(C)c1nc(CNS(=O)(=O)c2cccc(Cl)c2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)c1nc(CCCCNS(=O)(=O)c2cccc(Cl)c2)cs1
|
CN(C)c1nc(CNS(=O)(=O)c2cccc(Cl)c2)cs1
|
CN(C)c1nc(CCCCNS(=O)(=O)c2cccc(Cl)c2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C36"
}
|
Can you make molecule CN(C)c1nc(CNS(=O)(=O)c2cccc(Cl)c2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)c1nc(CCC=NS(=O)(=O)c2cccc(Cl)c2)cs1
|
CN(C)c1nc(CNS(=O)(=O)c2cccc(Cl)c2)cs1
|
CN(C)c1nc(CCC=NS(=O)(=O)c2cccc(Cl)c2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC&",
"old_substring": "C36"
}
|
Can you make molecule CN(C)c1nc(CNS(=O)(=O)c2cccc(Cl)c2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)c1nc(CCCCCNS(=O)(=O)c2cccc(Cl)c2)cs1
|
CN(C)c1nc(CNS(=O)(=O)c2cccc(Cl)c2)cs1
|
CN(C)c1nc(CCCCCNS(=O)(=O)c2cccc(Cl)c2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C36"
}
|
Can you make molecule CN(C)c1nc(CNS(=O)(=O)c2cccc(Cl)c2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)c1nc(C2CC(NS(=O)(=O)c3cccc(Cl)c3)C2)cs1
|
CN(C)c1nc(CNS(=O)(=O)c2cccc(Cl)c2)cs1
|
CN(C)c1nc(C2CC(NS(=O)(=O)c3cccc(Cl)c3)C2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C36"
}
|
Can you make molecule CN(C)c1nc(CNS(=O)(=O)c2cccc(Cl)c2)cs1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C)c1nc(SC(=S)ONS(=O)(=O)c2cccc(Cl)c2)cs1
|
CN(C)c1nc(CNS(=O)(=O)c2cccc(Cl)c2)cs1
|
CN(C)c1nc(SC(=S)ONS(=O)(=O)c2cccc(Cl)c2)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C36"
}
|
Can you make molecule CCCCn1c(N)nc2cc(Br)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)(C)n1c(N)nc2cc(Br)cnc21
|
CCCCn1c(N)nc2cc(Br)cnc21
|
CCCC(C)(C)n1c(N)nc2cc(Br)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&(C)C",
"old_substring": "CCCC3"
}
|
Can you make molecule CCCCn1c(N)nc2cc(Br)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCCC(=O)n1c(N)nc2cc(Br)cnc21
|
CCCCn1c(N)nc2cc(Br)cnc21
|
CCCCCCC(=O)n1c(N)nc2cc(Br)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCCC&=O",
"old_substring": "CCCC3"
}
|
Can you make molecule CCCCn1c(N)nc2cc(Br)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](C)n1c(N)nc2cc(Br)cnc21
|
CCCCn1c(N)nc2cc(Br)cnc21
|
CCCC[C@@H](C)n1c(N)nc2cc(Br)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]&C",
"old_substring": "CCCC3"
}
|
Can you make molecule CCCCn1c(N)nc2cc(Br)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC[C@@H](C)n1c(N)nc2cc(Br)cnc21
|
CCCCn1c(N)nc2cc(Br)cnc21
|
CCCCC[C@@H](C)n1c(N)nc2cc(Br)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC[C@H]&C",
"old_substring": "CCCC3"
}
|
Can you make molecule CCCCn1c(N)nc2cc(Br)cnc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C)(CC)n1c(N)nc2cc(Br)cnc21
|
CCCCn1c(N)nc2cc(Br)cnc21
|
CCC(C)(CC)n1c(N)nc2cc(Br)cnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(C)CC",
"old_substring": "CCCC3"
}
|
Can you make molecule COCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1
|
COCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1
|
COCCCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C4C5"
}
|
Can you make molecule COCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCCCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1
|
COCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1
|
COCCCCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C4C5"
}
|
Can you make molecule COCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1CC(N(Cc2ccsc2)C(=O)[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)C1
|
COCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1
|
COC1CC(N(Cc2ccsc2)C(=O)[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C4C5"
}
|
Can you make molecule COCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CO[C@@H](C)CCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1
|
COCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1
|
CO[C@@H](C)CCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C4C5"
}
|
Can you make molecule COCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC1CCC(N(Cc2ccsc2)C(=O)[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)CC1
|
COCCN(Cc1ccsc1)C(=O)[C@@H]1CC(=O)N(c2ccc(F)cc2)C1
|
COC1CCC(N(Cc2ccsc2)C(=O)[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C4C5"
}
|
Can you make molecule Cc1ccc2nc(CN3C(=O)OC(C)(C)C3=O)cn2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc(CC(=O)C(C)(C)C)cn2c1
|
Cc1ccc2nc(CN3C(=O)OC(C)(C)C3=O)cn2c1
|
Cc1ccc2nc(CC(=O)C(C)(C)C)cn2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)C",
"old_substring": "N14C(=O)OC(C)(C)C1=O"
}
|
Can you make molecule Cc1ccc2nc(CN3C(=O)OC(C)(C)C3=O)cn2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc(CC(=O)C(C)(C)CCl)cn2c1
|
Cc1ccc2nc(CN3C(=O)OC(C)(C)C3=O)cn2c1
|
Cc1ccc2nc(CC(=O)C(C)(C)CCl)cn2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)CCl",
"old_substring": "N14C(=O)OC(C)(C)C1=O"
}
|
Can you make molecule Cc1ccc2nc(CN3C(=O)OC(C)(C)C3=O)cn2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc(CN3CCCCC3)cn2c1
|
Cc1ccc2nc(CN3C(=O)OC(C)(C)C3=O)cn2c1
|
Cc1ccc2nc(CN3CCCCC3)cn2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCC1",
"old_substring": "N14C(=O)OC(C)(C)C1=O"
}
|
Can you make molecule Cc1ccc2nc(CN3C(=O)OC(C)(C)C3=O)cn2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc(CC(=O)C(Cl)(Cl)Cl)cn2c1
|
Cc1ccc2nc(CN3C(=O)OC(C)(C)C3=O)cn2c1
|
Cc1ccc2nc(CC(=O)C(Cl)(Cl)Cl)cn2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(Cl)(Cl)Cl",
"old_substring": "N14C(=O)OC(C)(C)C1=O"
}
|
Can you make molecule Cc1ccc2nc(CN3C(=O)OC(C)(C)C3=O)cn2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc2nc(CC(=O)C(C)(C)Br)cn2c1
|
Cc1ccc2nc(CN3C(=O)OC(C)(C)C3=O)cn2c1
|
Cc1ccc2nc(CC(=O)C(C)(C)Br)cn2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)Br",
"old_substring": "N14C(=O)OC(C)(C)C1=O"
}
|
Can you make molecule O=C(Nc1cncc2ccccc12)N[C@@H]1CCCc2occc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/SN[C@@H]1CCCc2occc21)Nc1cncc2ccccc12
|
O=C(Nc1cncc2ccccc12)N[C@@H]1CCCc2occc21
|
O=C(/C=C/SN[C@@H]1CCCc2occc21)Nc1cncc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(Nc1cncc2ccccc12)N[C@@H]1CCCc2occc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1C(=Nc2cncc3ccccc23)CCC1=N[C@@H]1CCCc2occc21
|
O=C(Nc1cncc2ccccc12)N[C@@H]1CCCc2occc21
|
O=C1C(=Nc2cncc3ccccc23)CCC1=N[C@@H]1CCCc2occc21
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C1C=&CCC1=&",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(Nc1cncc2ccccc12)N[C@@H]1CCCc2occc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1cncc2ccccc12)n1nc(N[C@@H]2CCCc3occc32)oc1=S
|
O=C(Nc1cncc2ccccc12)N[C@@H]1CCCc2occc21
|
O=C(Nc1cncc2ccccc12)n1nc(N[C@@H]2CCCc3occc32)oc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&n1nc&oc1=S",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(Nc1cncc2ccccc12)N[C@@H]1CCCc2occc21 less soluble in water? The output molecule should be similar to the input molecule.
|
C(=N/ONc1cncc2ccccc12)\c1ccc(N[C@@H]2CCCc3occc32)o1
|
O=C(Nc1cncc2ccccc12)N[C@@H]1CCCc2occc21
|
C(=N/ONc1cncc2ccccc12)\c1ccc(N[C@@H]2CCCc3occc32)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C/c1ccc&o1",
"old_substring": "O=C34"
}
|
Can you make molecule O=C(Nc1cncc2ccccc12)N[C@@H]1CCCc2occc21 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(N[C@@H]2CCCc3occc32)CC1)Nc1cncc2ccccc12
|
O=C(Nc1cncc2ccccc12)N[C@@H]1CCCc2occc21
|
O=C(NN=C1CCC(N[C@@H]2CCCc3occc32)CC1)Nc1cncc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C34"
}
|
Can you make molecule Cc1cc(C2=NC(=Cc3ccc(N4CCOCC4)c(F)c3)C(=O)O2)c(C)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(O)=Cc2ccc(N3CCOCC3)c(F)c2)cc1
|
Cc1cc(C2=NC(=Cc3ccc(N4CCOCC4)c(F)c3)C(=O)O2)c(C)o1
|
Cc1ccc(C(O)=Cc2ccc(N3CCOCC3)c(F)c2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(C=&O)cc1",
"old_substring": "Cc1cc(C2=NC=6C(=O)O2)c(C)o1"
}
|
Can you make molecule Cc1cc(C2=NC(=Cc3ccc(N4CCOCC4)c(F)c3)C(=O)O2)c(C)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C=Cc2ccc(N3CCOCC3)c(F)c2)cc(C)c1Cl
|
Cc1cc(C2=NC(=Cc3ccc(N4CCOCC4)c(F)c3)C(=O)O2)c(C)o1
|
Cc1cc(C=Cc2ccc(N3CCOCC3)c(F)c2)cc(C)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(C=&)cc(C)c1Cl",
"old_substring": "Cc1cc(C2=NC=6C(=O)O2)c(C)o1"
}
|
Can you make molecule Cc1cc(C2=NC(=Cc3ccc(N4CCOCC4)c(F)c3)C(=O)O2)c(C)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)cc(C=Cc2ccc(N3CCOCC3)c(F)c2)c1
|
Cc1cc(C2=NC(=Cc3ccc(N4CCOCC4)c(F)c3)C(=O)O2)c(C)o1
|
Cc1cc(C)cc(C=Cc2ccc(N3CCOCC3)c(F)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(C)cc(C=&)c1",
"old_substring": "Cc1cc(C2=NC=6C(=O)O2)c(C)o1"
}
|
Can you make molecule Cc1cc(C2=NC(=Cc3ccc(N4CCOCC4)c(F)c3)C(=O)O2)c(C)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C=Cc2ccc(N3CCOCC3)c(F)c2)cc1C
|
Cc1cc(C2=NC(=Cc3ccc(N4CCOCC4)c(F)c3)C(=O)O2)c(C)o1
|
Cc1cc(C)c(C=Cc2ccc(N3CCOCC3)c(F)c2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(C)c(C=&)cc1C",
"old_substring": "Cc1cc(C2=NC=6C(=O)O2)c(C)o1"
}
|
Can you make molecule Cc1cc(C2=NC(=Cc3ccc(N4CCOCC4)c(F)c3)C(=O)O2)c(C)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C(C#N)=Cc2ccc(N3CCOCC3)c(F)c2)cc1
|
Cc1cc(C2=NC(=Cc3ccc(N4CCOCC4)c(F)c3)C(=O)O2)c(C)o1
|
Cc1ccc(C(C#N)=Cc2ccc(N3CCOCC3)c(F)c2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(C=&C#N)cc1",
"old_substring": "Cc1cc(C2=NC=6C(=O)O2)c(C)o1"
}
|
Can you make molecule COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
COCSC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
|
COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
|
COCSC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO3"
}
|
Can you make molecule COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)SC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
|
COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
|
CC(=O)SC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO3"
}
|
Can you make molecule COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CON(C)CCCC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
|
COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
|
CON(C)CCCC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CON(C)CCC&",
"old_substring": "CO3"
}
|
Can you make molecule COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)CCCC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
|
COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
|
CC(=O)CCCC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)CCC&",
"old_substring": "CO3"
}
|
Can you make molecule COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCBr)C(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
|
COC(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
|
O=C(CCBr)C(=O)[C@@H]1[C@H](CBr)N1N1C(=O)c2ccccc2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCBr",
"old_substring": "CO3"
}
|
Can you make molecule O=C1COc2cc(C(=O)Nc3nc4c(s3)CCCC4)ccc2N1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C1COc2cc(CC(=O)SNc3nc4c(s3)CCCC4)ccc2N1
|
O=C1COc2cc(C(=O)Nc3nc4c(s3)CCCC4)ccc2N1
|
O=C1COc2cc(CC(=O)SNc3nc4c(s3)CCCC4)ccc2N1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C57=O"
}
|
Can you make molecule O=C1COc2cc(C(=O)Nc3nc4c(s3)CCCC4)ccc2N1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CCCC(=O)c1ccc2c(c1)OCC(=O)N2)Nc1nc2c(s1)CCCC2
|
O=C1COc2cc(C(=O)Nc3nc4c(s3)CCCC4)ccc2N1
|
O=C(CCCC(=O)c1ccc2c(c1)OCC(=O)N2)Nc1nc2c(s1)CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C57=O"
}
|
Can you make molecule O=C1COc2cc(C(=O)Nc3nc4c(s3)CCCC4)ccc2N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)Nc1nc2c(s1)CCCC2)c1ccc2c(c1)OCC(=O)N2
|
O=C1COc2cc(C(=O)Nc3nc4c(s3)CCCC4)ccc2N1
|
CC(C)(CC(=O)Nc1nc2c(s1)CCCC2)c1ccc2c(c1)OCC(=O)N2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C57=O"
}
|
Can you make molecule O=C1COc2cc(C(=O)Nc3nc4c(s3)CCCC4)ccc2N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)Nc1nc2c(s1)CCCC2)c1ccc2c(c1)OCC(=O)N2
|
O=C1COc2cc(C(=O)Nc3nc4c(s3)CCCC4)ccc2N1
|
CC(C)(CCC(=O)Nc1nc2c(s1)CCCC2)c1ccc2c(c1)OCC(=O)N2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C57=O"
}
|
Can you make molecule O=C1COc2cc(C(=O)Nc3nc4c(s3)CCCC4)ccc2N1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SNc1nc2c(s1)CCCC2)c1ccc2c(c1)OCC(=O)N2
|
O=C1COc2cc(C(=O)Nc3nc4c(s3)CCCC4)ccc2N1
|
C[C@H](C(=O)SNc1nc2c(s1)CCCC2)c1ccc2c(c1)OCC(=O)N2
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C57=O"
}
|
Can you make molecule Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3)C2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3Cl)C2=O)cc1
|
Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3)C2=O)cc1
|
Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3Cl)C2=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccc(Cl)cc1Cl",
"old_substring": "C=4c1ccc(Cl)cc1"
}
|
Can you make molecule Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3)C2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=C1C(=O)NN(c2ccc(C)cc2)C1=O)c1ccc(Cl)cc1F
|
Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3)C2=O)cc1
|
CC(=C1C(=O)NN(c2ccc(C)cc2)C1=O)c1ccc(Cl)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&c1ccc(Cl)cc1F",
"old_substring": "C=4c1ccc(Cl)cc1"
}
|
Can you make molecule Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3)C2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)c(Cl)c3)C2=O)cc1
|
Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3)C2=O)cc1
|
Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)c(Cl)c3)C2=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1ccc(Cl)c(Cl)c1",
"old_substring": "C=4c1ccc(Cl)cc1"
}
|
Can you make molecule Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3)C2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(N2NC(=O)C(=Cc3cc(Cl)ccc3Cl)C2=O)cc1
|
Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3)C2=O)cc1
|
Cc1ccc(N2NC(=O)C(=Cc3cc(Cl)ccc3Cl)C2=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1cc(Cl)ccc1Cl",
"old_substring": "C=4c1ccc(Cl)cc1"
}
|
Can you make molecule Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3)C2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(N2NC(=O)C(=Cc3cccc(Cl)c3Cl)C2=O)cc1
|
Cc1ccc(N2NC(=O)C(=Cc3ccc(Cl)cc3)C2=O)cc1
|
Cc1ccc(N2NC(=O)C(=Cc3cccc(Cl)c3Cl)C2=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&c1cccc(Cl)c1Cl",
"old_substring": "C=4c1ccc(Cl)cc1"
}
|
Can you make molecule CC[C@H](C)C[C@@H](C)NC(=O)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C[C@@H](C)NC(=O)CC(C)(C)N1C(=O)[C@H]2CCCC[C@H]2C1=O
|
CC[C@H](C)C[C@@H](C)NC(=O)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O
|
CC[C@H](C)C[C@@H](C)NC(=O)CC(C)(C)N1C(=O)[C@H]2CCCC[C@H]2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C3(=O)CC5"
}
|
Can you make molecule CC[C@H](C)C[C@@H](C)NC(=O)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C[C@@H](C)NC(=O)CCC(C)(C)N1C(=O)[C@H]2CCCC[C@H]2C1=O
|
CC[C@H](C)C[C@@H](C)NC(=O)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O
|
CC[C@H](C)C[C@@H](C)NC(=O)CCC(C)(C)N1C(=O)[C@H]2CCCC[C@H]2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C3(=O)CC5"
}
|
Can you make molecule CC[C@H](C)C[C@@H](C)NC(=O)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C[C@@H](C)NC(=O)C[C@@H](Br)N1C(=O)[C@H]2CCCC[C@H]2C1=O
|
CC[C@H](C)C[C@@H](C)NC(=O)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O
|
CC[C@H](C)C[C@@H](C)NC(=O)C[C@@H](Br)N1C(=O)[C@H]2CCCC[C@H]2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C3(=O)CC5"
}
|
Can you make molecule CC[C@H](C)C[C@@H](C)NC(=O)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C[C@@H](C)NSC(=O)[C@@H](C)N1C(=O)[C@H]2CCCC[C@H]2C1=O
|
CC[C@H](C)C[C@@H](C)NC(=O)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O
|
CC[C@H](C)C[C@@H](C)NSC(=O)[C@@H](C)N1C(=O)[C@H]2CCCC[C@H]2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C3(=O)CC5"
}
|
Can you make molecule CC[C@H](C)C[C@@H](C)NC(=O)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C[C@@H](C)NC(=O)[C@H](C)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O
|
CC[C@H](C)C[C@@H](C)NC(=O)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O
|
CC[C@H](C)C[C@@H](C)NC(=O)[C@H](C)CCN1C(=O)[C@H]2CCCC[C@H]2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)[C@H](C)CC&",
"old_substring": "C3(=O)CC5"
}
|
Can you make molecule Cc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(CC(=O)SNc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
|
Cc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
|
Cc1cccc(CC(=O)SNc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C(=O)CCCC(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
|
Cc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
|
Cc1cccc(C(=O)CCCC(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C(C)(C)CC(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
|
Cc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
|
Cc1cccc(C(C)(C)CC(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C(C)(C)CCC(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
|
Cc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
|
Cc1cccc(C(C)(C)CCC(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C47=O"
}
|
Can you make molecule Cc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@H](C)C(=O)SNc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
|
Cc1cccc(C(=O)Nc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
|
Cc1cccc([C@H](C)C(=O)SNc2cc3c(cc2N2CCCCC2)n(C)c(=O)c(=O)n3C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C47=O"
}
|
Can you make molecule CNc1snc(C)c1C(=O)O[C@H](C)C(=O)Nc1c(F)cccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1c(C)ccc(C(=O)O[C@H](C)C(=O)Nc2c(F)cccc2F)c1C
|
CNc1snc(C)c1C(=O)O[C@H](C)C(=O)Nc1c(F)cccc1F
|
CNc1c(C)ccc(C(=O)O[C@H](C)C(=O)Nc2c(F)cccc2F)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(C)ccc&c1C",
"old_substring": "c15snc(C)c17"
}
|
Can you make molecule CNc1snc(C)c1C(=O)O[C@H](C)C(=O)Nc1c(F)cccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1cc(Cl)cn(C(=O)O[C@H](C)C(=O)Nc2c(F)cccc2F)c1=O
|
CNc1snc(C)c1C(=O)O[C@H](C)C(=O)Nc1c(F)cccc1F
|
CNc1cc(Cl)cn(C(=O)O[C@H](C)C(=O)Nc2c(F)cccc2F)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Cl)cn&c1=O",
"old_substring": "c15snc(C)c17"
}
|
Can you make molecule CNc1snc(C)c1C(=O)O[C@H](C)C(=O)Nc1c(F)cccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1c(Cl)cc(C(=O)O[C@H](C)C(=O)Nc2c(F)cccc2F)cc1Cl
|
CNc1snc(C)c1C(=O)O[C@H](C)C(=O)Nc1c(F)cccc1F
|
CNc1c(Cl)cc(C(=O)O[C@H](C)C(=O)Nc2c(F)cccc2F)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(Cl)cc&cc1Cl",
"old_substring": "c15snc(C)c17"
}
|
Can you make molecule CNc1snc(C)c1C(=O)O[C@H](C)C(=O)Nc1c(F)cccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1ccc(C)c2sc(C(=O)O[C@H](C)C(=O)Nc3c(F)cccc3F)nc12
|
CNc1snc(C)c1C(=O)O[C@H](C)C(=O)Nc1c(F)cccc1F
|
CNc1ccc(C)c2sc(C(=O)O[C@H](C)C(=O)Nc3c(F)cccc3F)nc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(C)c2sc&nc12",
"old_substring": "c15snc(C)c17"
}
|
Can you make molecule CNc1snc(C)c1C(=O)O[C@H](C)C(=O)Nc1c(F)cccc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CNc1c(C)cc(C)c(C(=O)O[C@H](C)C(=O)Nc2c(F)cccc2F)c1C
|
CNc1snc(C)c1C(=O)O[C@H](C)C(=O)Nc1c(F)cccc1F
|
CNc1c(C)cc(C)c(C(=O)O[C@H](C)C(=O)Nc2c(F)cccc2F)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(C)cc(C)c&c1C",
"old_substring": "c15snc(C)c17"
}
|
Can you make molecule C[NH2+][C@H](COC(C)C)c1ncccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)O.c1cnc([C@H]2CC[NH+]3CCC2CC3)nc1
|
C[NH2+][C@H](COC(C)C)c1ncccn1
|
CC(C)O.c1cnc([C@H]2CC[NH+]3CCC2CC3)nc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&CC1",
"old_substring": "C[NH2+]4"
}
|
Can you make molecule C[NH2+][C@H](COC(C)C)c1ncccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
C1=C2CC[C@H](c3ncccn3)[NH+](CC1)C2.CC(C)O
|
C[NH2+][C@H](COC(C)C)c1ncccn1
|
C1=C2CC[C@H](c3ncccn3)[NH+](CC1)C2.CC(C)O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C1=CCC[NH+]&C1",
"old_substring": "C[NH2+]4"
}
|
Can you make molecule C[NH2+][C@H](COC(C)C)c1ncccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)O.CC12CC[NH+](CC1)[C@@H](c1ncccn1)C2
|
C[NH2+][C@H](COC(C)C)c1ncccn1
|
CC(C)O.CC12CC[NH+](CC1)[C@@H](c1ncccn1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CC[NH+]&CC1",
"old_substring": "C[NH2+]4"
}
|
Can you make molecule C[NH2+][C@H](COC(C)C)c1ncccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)O.CC12CC[NH+](CC[C@@H]1c1ncccn1)CC2
|
C[NH2+][C@H](COC(C)C)c1ncccn1
|
CC(C)O.CC12CC[NH+](CC[C@@H]1c1ncccn1)CC2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&(C)CC1",
"old_substring": "C[NH2+]4"
}
|
Can you make molecule C[NH2+][C@H](COC(C)C)c1ncccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)O.Cc1c2[nH+]cn1[C@@H](c1ncccn1)C2
|
C[NH2+][C@H](COC(C)C)c1ncccn1
|
CC(C)O.Cc1c2[nH+]cn1[C@@H](c1ncccn1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&[nH+]cn1&",
"old_substring": "C[NH2+]4"
}
|
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