prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule CC[C@H](Sc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](SCSc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1
|
CC[C@H](Sc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1
|
CC[C@H](SCSc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&CS&",
"old_substring": "S46"
}
|
Can you make molecule CC[C@H](Sc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1)N1CCSc2ccc(-c3cc(C)c4cccc(C)c4n3)cc21
|
CC[C@H](Sc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1
|
CC[C@@H](C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1)N1CCSc2ccc(-c3cc(C)c4cccc(C)c4n3)cc21
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSc2ccc&cc21",
"old_substring": "S46"
}
|
Can you make molecule CC[C@H](Sc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C[S@@+]([O-])C(Cl)(Cl)c1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1
|
CC[C@H](Sc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1
|
CC[C@H](C[S@@+]([O-])C(Cl)(Cl)c1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=[S@](C&)C&(Cl)Cl",
"old_substring": "S46"
}
|
Can you make molecule CC[C@H](Sc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](S/C(Cl)=C(\C#N)Nc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1
|
CC[C@H](Sc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1
|
CC[C@H](S/C(Cl)=C(\C#N)Nc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&/C(Cl)=C(\\C#N)N&",
"old_substring": "S46"
}
|
Can you make molecule CC[C@H](Sc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1)n1c(=S)n(-c2cc(C)c3cccc(C)c3n2)c2ccccc21
|
CC[C@H](Sc1cc(C)c2cccc(C)c2n1)C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1
|
CC[C@@H](C(=O)Nc1nc2ccc(S(N)(=O)=O)cc2s1)n1c(=S)n(-c2cc(C)c3cccc(C)c3n2)c2ccccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&c(=S)n&c2ccccc21",
"old_substring": "S46"
}
|
Can you make molecule COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(C)cn2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2cc(C)ccn2)C1
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(C)cn2)C1
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2cc(C)ccn2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(C)ccn1",
"old_substring": "c17ncc(C)cn1"
}
|
Can you make molecule COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(C)cn2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2nc(C)ncc2Cl)C1
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(C)cn2)C1
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2nc(C)ncc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ncc(Cl)c&n1",
"old_substring": "c17ncc(C)cn1"
}
|
Can you make molecule COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(C)cn2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(Br)cn2)C1
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(C)cn2)C1
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(Br)cn2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc(Br)cn1",
"old_substring": "c17ncc(C)cn1"
}
|
Can you make molecule COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(C)cn2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2cc(Cl)cn2C)C1
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(C)cn2)C1
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2cc(Cl)cn2C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Cl)cn1C",
"old_substring": "c17ncc(C)cn1"
}
|
Can you make molecule COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(C)cn2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2csc(C)n2)C1
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2ncc(C)cn2)C1
|
COC(=O)[C@]1(NC2CC2)CC[C@H](Sc2csc(C)n2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&csc(C)n1",
"old_substring": "c17ncc(C)cn1"
}
|
Can you make molecule COc1ccccc1Nc1nn(CN(C)OC)c(=S)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccccc1Nc1nn(CN(C)OC)c(=S)s1
|
COc1ccccc1Nc1nn(CN(C)OC)c(=S)s1
|
COCc1ccccc1Nc1nn(CN(C)OC)c(=S)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO2"
}
|
Can you make molecule COc1ccccc1Nc1nn(CN(C)OC)c(=S)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CON(C)Cn1nc(Nc2ccccc2C2OCc3ccccc3CO2)sc1=S
|
COc1ccccc1Nc1nn(CN(C)OC)c(=S)s1
|
CON(C)Cn1nc(Nc2ccccc2C2OCc3ccccc3CO2)sc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&OCc2ccccc2CO1",
"old_substring": "CO2"
}
|
Can you make molecule COc1ccccc1Nc1nn(CN(C)OC)c(=S)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CON(C)Cn1nc(Nc2ccccc2C2(O)Cc3ccccc3C2)sc1=S
|
COc1ccccc1Nc1nn(CN(C)OC)c(=S)s1
|
CON(C)Cn1nc(Nc2ccccc2C2(O)Cc3ccccc3C2)sc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(O)Cc2ccccc2C1",
"old_substring": "CO2"
}
|
Can you make molecule COc1ccccc1Nc1nn(CN(C)OC)c(=S)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CON(C)Cn1nc(Nc2ccccc2C2=CC3=NN3C[C@@H](C)CO2)sc1=S
|
COc1ccccc1Nc1nn(CN(C)OC)c(=S)s1
|
CON(C)Cn1nc(Nc2ccccc2C2=CC3=NN3C[C@@H](C)CO2)sc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1COc2cc&nn2C1",
"old_substring": "CO2"
}
|
Can you make molecule COc1ccccc1Nc1nn(CN(C)OC)c(=S)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CON(C)Cn1nc(Nc2ccccc2N2CCOc3ccccc32)sc1=S
|
COc1ccccc1Nc1nn(CN(C)OC)c(=S)s1
|
CON(C)Cn1nc(Nc2ccccc2N2CCOc3ccccc32)sc1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2ccccc21",
"old_substring": "CO2"
}
|
Can you make molecule Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)C)n2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(Cl)(Cl)Cl)n2)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)C)n2)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(Cl)(Cl)Cl)n2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(Cl)(Cl)Cl",
"old_substring": "C4(C)(C)C"
}
|
Can you make molecule Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)C)n2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)CC(C)(C)C)n2)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)C)n2)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)CC(C)(C)C)n2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)(C)CC(C)(C)C",
"old_substring": "C4(C)(C)C"
}
|
Can you make molecule Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)C)n2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(CCCC(C)(C)C)n2)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)C)n2)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(CCCC(C)(C)C)n2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(C)(C)C",
"old_substring": "C4(C)(C)C"
}
|
Can you make molecule Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)C)n2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(CCCC(F)(F)F)n2)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)C)n2)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(CCCC(F)(F)F)n2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C4(C)(C)C"
}
|
Can you make molecule Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)C)n2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(CCCCC(F)(F)F)n2)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)C)n2)c1C
|
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(CCCCC(F)(F)F)n2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C4(C)(C)C"
}
|
Can you make molecule CC(C)(O)C#Cc1ccc(C[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(O)C#Cc1ccc(CCCC[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
|
CC(C)(O)C#Cc1ccc(C[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
|
CC(C)(O)C#Cc1ccc(CCCC[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C58"
}
|
Can you make molecule CC(C)(O)C#Cc1ccc(C[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(O)C#Cc1ccc(CCCCC[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
|
CC(C)(O)C#Cc1ccc(C[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
|
CC(C)(O)C#Cc1ccc(CCCCC[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C58"
}
|
Can you make molecule CC(C)(O)C#Cc1ccc(C[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(O)C#Cc1ccc(C2CC([NH2+][C@H]3CCCN(c4nc5ccccc5s4)C3)C2)s1
|
CC(C)(O)C#Cc1ccc(C[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
|
CC(C)(O)C#Cc1ccc(C2CC([NH2+][C@H]3CCCN(c4nc5ccccc5s4)C3)C2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C58"
}
|
Can you make molecule CC(C)(O)C#Cc1ccc(C[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(O)C#Cc1ccc(SC(=S)O[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
|
CC(C)(O)C#Cc1ccc(C[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
|
CC(C)(O)C#Cc1ccc(SC(=S)O[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C58"
}
|
Can you make molecule CC(C)(O)C#Cc1ccc(C[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(O)C#Cc1ccc(NC(=S)S[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
|
CC(C)(O)C#Cc1ccc(C[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
|
CC(C)(O)C#Cc1ccc(NC(=S)S[NH2+][C@H]2CCCN(c3nc4ccccc4s3)C2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C58"
}
|
Can you make molecule COc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1
|
COc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1
|
COCc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1
|
COc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1
|
COCSc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(SC(C)=O)cc1S(=O)(=O)n1cc2c(=O)n(C)c(=O)n(C)c2n1
|
COc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1
|
COc1ccc(SC(C)=O)cc1S(=O)(=O)n1cc2c(=O)n(C)c(=O)n(C)c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)CS)cc1S(=O)(=O)n1cc2c(=O)n(C)c(=O)n(C)c2n1
|
COc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1
|
COc1ccc(C(=O)CS)cc1S(=O)(=O)n1cc2c(=O)n(C)c(=O)n(C)c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO4"
}
|
Can you make molecule COc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)CI)cc1S(=O)(=O)n1cc2c(=O)n(C)c(=O)n(C)c2n1
|
COc1ccc(OC)c(S(=O)(=O)n2cc3c(=O)n(C)c(=O)n(C)c3n2)c1
|
COc1ccc(C(=O)CI)cc1S(=O)(=O)n1cc2c(=O)n(C)c(=O)n(C)c2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO4"
}
|
Can you make molecule C/[NH+]=C(/NCc1noc(C(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
C/[NH+]=C(/NCc1noc(C(Cl)(Cl)Cl)n1)N[C@@H](C)c1ccc(F)cc1F
|
C/[NH+]=C(/NCc1noc(C(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F
|
C/[NH+]=C(/NCc1noc(C(Cl)(Cl)Cl)n1)N[C@@H](C)c1ccc(F)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(Cl)(Cl)Cl",
"old_substring": "C5(C)(C)C"
}
|
Can you make molecule C/[NH+]=C(/NCc1noc(C(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
C/[NH+]=C(/NCc1noc(C(C)(C)CC(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F
|
C/[NH+]=C(/NCc1noc(C(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F
|
C/[NH+]=C(/NCc1noc(C(C)(C)CC(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)(C)CC(C)(C)C",
"old_substring": "C5(C)(C)C"
}
|
Can you make molecule C/[NH+]=C(/NCc1noc(C(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
C/[NH+]=C(/NCc1noc(CCCC(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F
|
C/[NH+]=C(/NCc1noc(C(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F
|
C/[NH+]=C(/NCc1noc(CCCC(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(C)(C)C",
"old_substring": "C5(C)(C)C"
}
|
Can you make molecule C/[NH+]=C(/NCc1noc(C(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
C/[NH+]=C(/NCc1noc(CCCC(F)(F)F)n1)N[C@@H](C)c1ccc(F)cc1F
|
C/[NH+]=C(/NCc1noc(C(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F
|
C/[NH+]=C(/NCc1noc(CCCC(F)(F)F)n1)N[C@@H](C)c1ccc(F)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C5(C)(C)C"
}
|
Can you make molecule C/[NH+]=C(/NCc1noc(C(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
C/[NH+]=C(/NCc1noc(CCCCC(F)(F)F)n1)N[C@@H](C)c1ccc(F)cc1F
|
C/[NH+]=C(/NCc1noc(C(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F
|
C/[NH+]=C(/NCc1noc(CCCCC(F)(F)F)n1)N[C@@H](C)c1ccc(F)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C5(C)(C)C"
}
|
Can you make molecule Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Br)cc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnsc1CC(=O)SNc1nnc(-c2ccc(Br)cc2)o1
|
Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Br)cc2)o1
|
Cc1nnsc1CC(=O)SNc1nnc(-c2ccc(Br)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Br)cc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnsc1C(=O)CCCC(=O)Nc1nnc(-c2ccc(Br)cc2)o1
|
Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Br)cc2)o1
|
Cc1nnsc1C(=O)CCCC(=O)Nc1nnc(-c2ccc(Br)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Br)cc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnsc1C(C)(C)CC(=O)Nc1nnc(-c2ccc(Br)cc2)o1
|
Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Br)cc2)o1
|
Cc1nnsc1C(C)(C)CC(=O)Nc1nnc(-c2ccc(Br)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Br)cc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnsc1C(C)(C)CCC(=O)Nc1nnc(-c2ccc(Br)cc2)o1
|
Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Br)cc2)o1
|
Cc1nnsc1C(C)(C)CCC(=O)Nc1nnc(-c2ccc(Br)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Br)cc2)o1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nnsc1[C@H](C)C(=O)SNc1nnc(-c2ccc(Br)cc2)o1
|
Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Br)cc2)o1
|
Cc1nnsc1[C@H](C)C(=O)SNc1nnc(-c2ccc(Br)cc2)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C35=O"
}
|
Can you make molecule CCN(Cc1ccc(OC)c(OC)c1)C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1sc2c(c1Cc1ccc(OC)c(OC)c1)CCN(C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1)C2
|
CCN(Cc1ccc(OC)c(OC)c1)C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1
|
CCc1sc2c(c1Cc1ccc(OC)c(OC)c1)CCN(C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCc2c(sc&c2&)C1",
"old_substring": "N256"
}
|
Can you make molecule CCN(Cc1ccc(OC)c(OC)c1)C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(Cc2ccc(OC)c(OC)c2)cc2c1OCCN(C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1)C2
|
CCN(Cc1ccc(OC)c(OC)c1)C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1
|
CCc1cc(Cc2ccc(OC)c(OC)c2)cc2c1OCCN(C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOc2c&cc&cc2C1",
"old_substring": "N256"
}
|
Can you make molecule CCN(Cc1ccc(OC)c(OC)c1)C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC1(Cc2ccc(OC)c(OC)c2)CCN(C(=O)C[NH+]2CC[C@@H](C)[C@H](O)C2)C1
|
CCN(Cc1ccc(OC)c(OC)c1)C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1
|
CCC1(Cc2ccc(OC)c(OC)c2)CCN(C(=O)C[NH+]2CC[C@@H](C)[C@H](O)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC&&C1",
"old_substring": "N256"
}
|
Can you make molecule CCN(Cc1ccc(OC)c(OC)c1)C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC1(Cc2ccc(OC)c(OC)c2)CCCN(C(=O)C[NH+]2CC[C@@H](C)[C@H](O)C2)C1
|
CCN(Cc1ccc(OC)c(OC)c1)C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1
|
CCC1(Cc2ccc(OC)c(OC)c2)CCCN(C(=O)C[NH+]2CC[C@@H](C)[C@H](O)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC&&C1",
"old_substring": "N256"
}
|
Can you make molecule CCN(Cc1ccc(OC)c(OC)c1)C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1oc(C(=O)C[NH+]2CC[C@@H](C)[C@H](O)C2)c(C#N)c1Cc1ccc(OC)c(OC)c1
|
CCN(Cc1ccc(OC)c(OC)c1)C(=O)C[NH+]1CC[C@@H](C)[C@H](O)C1
|
CCc1oc(C(=O)C[NH+]2CC[C@@H](C)[C@H](O)C2)c(C#N)c1Cc1ccc(OC)c(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N#Cc1c&oc&c1&",
"old_substring": "N256"
}
|
Can you make molecule O=C([O-])[C@H]1CCCCN1C(=O)CSCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])CCC[C@H]1CCCCN1C(=O)CSCc1ccccc1
|
O=C([O-])[C@H]1CCCCN1C(=O)CSCc1ccccc1
|
O=C([O-])CCC[C@H]1CCCCN1C(=O)CSCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C([O-])CCC&",
"old_substring": "O=C5[O-]"
}
|
Can you make molecule O=C([O-])[C@H]1CCCCN1C(=O)CSCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])CCCCC[C@H]1CCCCN1C(=O)CSCc1ccccc1
|
O=C([O-])[C@H]1CCCCN1C(=O)CSCc1ccccc1
|
O=C([O-])CCCCC[C@H]1CCCCN1C(=O)CSCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C([O-])CCCCC&",
"old_substring": "O=C5[O-]"
}
|
Can you make molecule O=C([O-])[C@H]1CCCCN1C(=O)CSCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C([O-])CCCC(=O)[C@H]1CCCCN1C(=O)CSCc1ccccc1
|
O=C([O-])[C@H]1CCCCN1C(=O)CSCc1ccccc1
|
O=C([O-])CCCC(=O)[C@H]1CCCCN1C(=O)CSCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C([O-])CCCC&=O",
"old_substring": "O=C5[O-]"
}
|
Can you make molecule O=C([O-])[C@H]1CCCCN1C(=O)CSCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=CO[C@H]1CCCCN1C(=O)CSCc1ccccc1
|
O=C([O-])[C@H]1CCCCN1C(=O)CSCc1ccccc1
|
O=CO[C@H]1CCCCN1C(=O)CSCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=CO&",
"old_substring": "O=C5[O-]"
}
|
Can you make molecule O=C([O-])[C@H]1CCCCN1C(=O)CSCc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NO)[C@H]1CCCCN1C(=O)CSCc1ccccc1
|
O=C([O-])[C@H]1CCCCN1C(=O)CSCc1ccccc1
|
O=C(NO)[C@H]1CCCCN1C(=O)CSCc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NO",
"old_substring": "O=C5[O-]"
}
|
Can you make molecule Cc1cccc([C@H](O)C[C@@H]2CCCCC[NH2+]2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@H](O)C[C@@H]2CCCNCC2)c1
|
Cc1cccc([C@H](O)C[C@@H]2CCCCC[NH2+]2)c1
|
Cc1cccc([C@H](O)C[C@@H]2CCCNCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCN&CC1",
"old_substring": "[C@@H]13CCCCC[NH2+]1"
}
|
Can you make molecule Cc1cccc([C@H](O)C[C@@H]2CCCCC[NH2+]2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@H](O)C[C@@H]2CCCO2)c1
|
Cc1cccc([C@H](O)C[C@@H]2CCCCC[NH2+]2)c1
|
Cc1cccc([C@H](O)C[C@@H]2CCCO2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@H]&O1",
"old_substring": "[C@@H]13CCCCC[NH2+]1"
}
|
Can you make molecule Cc1cccc([C@H](O)C[C@@H]2CCCCC[NH2+]2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCC12C[C@H]2C[C@@H](O)c1cccc(C)c1
|
Cc1cccc([C@H](O)C[C@@H]2CCCCC[NH2+]2)c1
|
CCN1CCC12C[C@H]2C[C@@H](O)c1cccc(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC12CCN&CC2",
"old_substring": "[C@@H]13CCCCC[NH2+]1"
}
|
Can you make molecule Cc1cccc([C@H](O)C[C@@H]2CCCCC[NH2+]2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@H](O)CC2CCCC2)c1
|
Cc1cccc([C@H](O)C[C@@H]2CCCCC[NH2+]2)c1
|
Cc1cccc([C@H](O)CC2CCCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]13CCCCC[NH2+]1"
}
|
Can you make molecule Cc1cccc([C@H](O)C[C@@H]2CCCCC[NH2+]2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc([C@H](O)CC2CCCCCC2)c1
|
Cc1cccc([C@H](O)C[C@@H]2CCCCC[NH2+]2)c1
|
Cc1cccc([C@H](O)CC2CCCCCC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@H]&C1",
"old_substring": "[C@@H]13CCCCC[NH2+]1"
}
|
Can you make molecule O=C(C1CCCCC1)N1CCN(Cn2cc(Br)cn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C1CCCCC1)N1CCN(Cn2cc(Br)c(I)n2)CC1
|
O=C(C1CCCCC1)N1CCN(Cn2cc(Br)cn2)CC1
|
O=C(C1CCCCC1)N1CCN(Cn2cc(Br)c(I)n2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc(Br)c(I)n1",
"old_substring": "n15cc(Br)cn1"
}
|
Can you make molecule O=C(C1CCCCC1)N1CCN(Cn2cc(Br)cn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C1CCCCC1)N1CCN(Cn2nc(Br)c(Br)c2Br)CC1
|
O=C(C1CCCCC1)N1CCN(Cn2cc(Br)cn2)CC1
|
O=C(C1CCCCC1)N1CCN(Cn2nc(Br)c(Br)c2Br)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&nc(Br)c(Br)c1Br",
"old_substring": "n15cc(Br)cn1"
}
|
Can you make molecule O=C(C1CCCCC1)N1CCN(Cn2cc(Br)cn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(CN2CCN(C(=O)C3CCCCC3)CC2)c(C)c1Br
|
O=C(C1CCCCC1)N1CCN(Cn2cc(Br)cn2)CC1
|
Cc1nn(CN2CCN(C(=O)C3CCCCC3)CC2)c(C)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&nc(C)c(Br)c1C",
"old_substring": "n15cc(Br)cn1"
}
|
Can you make molecule O=C(C1CCCCC1)N1CCN(Cn2cc(Br)cn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1cc(Br)cc(CN2CCN(C(=O)C3CCCCC3)CC2)c1=O
|
O=C(C1CCCCC1)N1CCN(Cn2cc(Br)cn2)CC1
|
Cn1cc(Br)cc(CN2CCN(C(=O)C3CCCCC3)CC2)c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cn1cc(Br)cc&c1=O",
"old_substring": "n15cc(Br)cn1"
}
|
Can you make molecule O=C(C1CCCCC1)N1CCN(Cn2cc(Br)cn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(C1CCCCC1)N1CCN(Cc2nc(Br)c3ccccn23)CC1
|
O=C(C1CCCCC1)N1CCN(Cn2cc(Br)cn2)CC1
|
O=C(C1CCCCC1)N1CCN(Cc2nc(Br)c3ccccn23)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc(Br)c2ccccn12",
"old_substring": "n15cc(Br)cn1"
}
|
Can you make molecule Cc1ccccc1COc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1CCCCOc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
|
Cc1ccccc1COc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
|
Cc1ccccc1CCCCOc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C46"
}
|
Can you make molecule Cc1ccccc1COc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1CCCCCOc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
|
Cc1ccccc1COc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
|
Cc1ccccc1CCCCCOc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C46"
}
|
Can you make molecule Cc1ccccc1COc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1C1CC(Oc2ccc([C@@H]3C4=C(CCCC4=O)Nc4nnnn43)cc2)C1
|
Cc1ccccc1COc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
|
Cc1ccccc1C1CC(Oc2ccc([C@@H]3C4=C(CCCC4=O)Nc4nnnn43)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C46"
}
|
Can you make molecule Cc1ccccc1COc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1SC(=S)OOc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
|
Cc1ccccc1COc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
|
Cc1ccccc1SC(=S)OOc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C46"
}
|
Can you make molecule Cc1ccccc1COc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccccc1NC(=S)SOc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
|
Cc1ccccc1COc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
|
Cc1ccccc1NC(=S)SOc1ccc([C@@H]2C3=C(CCCC3=O)Nc3nnnn32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C46"
}
|
Can you make molecule CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CC[C@@H](S(C)(=O)=O)C2)C12CCCCC2
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CC[C@@H](S(C)(=O)=O)C2)C12CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]18CCCN6C1"
}
|
Can you make molecule CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@H](CCl)CCCS(C)(=O)=O)C12CCCCC2
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@H](CCl)CCCS(C)(=O)=O)C12CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]18CCCN6C1"
}
|
Can you make molecule CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@H]2CCC[C@H](S(C)(=O)=O)C2)C12CCCCC2
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@H]2CCC[C@H](S(C)(=O)=O)C2)C12CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&C1",
"old_substring": "[C@@H]18CCCN6C1"
}
|
Can you make molecule CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@H]2CCCC[C@H](S(C)(=O)=O)C2)C12CCCCC2
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@H]2CCCC[C@H](S(C)(=O)=O)C2)C12CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@H]&C1",
"old_substring": "[C@@H]18CCCN6C1"
}
|
Can you make molecule CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@H]2CCC[C@H](S(C)(=O)=O)CC2)C12CCCCC2
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@@H]2CCCN(S(C)(=O)=O)C2)C12CCCCC2
|
CCO[C@@H]1C[C@@H]([NH+](C)C[C@H]2CCC[C@H](S(C)(=O)=O)CC2)C12CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCC[C@H]&CC1",
"old_substring": "[C@@H]18CCCN6C1"
}
|
Can you make molecule CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4)C3=O)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4Cl)C3=O)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4)C3=O)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4Cl)C3=O)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4)C3=O)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccc(I)cc4)C3=O)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4)C3=O)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccc(I)cc4)C3=O)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4)C3=O)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccc(C)c(I)c4)C3=O)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4)C3=O)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccc(C)c(I)c4)C3=O)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4)C3=O)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4cccc(Br)c4)C3=O)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4)C3=O)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4cccc(Br)c4)C3=O)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4)C3=O)ccc21 less soluble in water? The output molecule should be similar to the input molecule.
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4cccc(C)c4C)C3=O)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4ccccc4)C3=O)ccc21
|
CCn1c(=O)c(=O)[nH]c2cc(C(=O)NN3C(=O)N[C@](C)(c4cccc(C)c4C)C3=O)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c17ccccc1"
}
|
Can you make molecule COc1cc(OC)cc([C@@H](NC(=O)N(C)C2CCCCC2)c2nccn2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)N[C@H]1CC[C](c2nccn2C)C1)C1CCCCC1.COc1cccc(OC)c1
|
COc1cc(OC)cc([C@@H](NC(=O)N(C)C2CCCCC2)c2nccn2C)c1
|
CN(C(=O)N[C@H]1CC[C](c2nccn2C)C1)C1CCCCC1.COc1cccc(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@]&&C1",
"old_substring": "[C@H]79%10"
}
|
Can you make molecule COc1cc(OC)cc([C@@H](NC(=O)N(C)C2CCCCC2)c2nccn2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)N[C@H]1CC[C](c2nccn2C)C1)C1CCCCC1.COc1cccc(OC)c1
|
COc1cc(OC)cc([C@@H](NC(=O)N(C)C2CCCCC2)c2nccn2C)c1
|
CN(C(=O)N[C@H]1CC[C](c2nccn2C)C1)C1CCCCC1.COc1cccc(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@@]&&C1",
"old_substring": "[C@H]79%10"
}
|
Can you make molecule COc1cc(OC)cc([C@@H](NC(=O)N(C)C2CCCCC2)c2nccn2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)N[C@@H]1CCC[C](c2nccn2C)C1)C1CCCCC1.COc1cccc(OC)c1
|
COc1cc(OC)cc([C@@H](NC(=O)N(C)C2CCCCC2)c2nccn2C)c1
|
CN(C(=O)N[C@@H]1CCC[C](c2nccn2C)C1)C1CCCCC1.COc1cccc(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCC[C@]&&C1",
"old_substring": "[C@H]79%10"
}
|
Can you make molecule COc1cc(OC)cc([C@@H](NC(=O)N(C)C2CCCCC2)c2nccn2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)N[C@H]1C[C](c2nccn2C)CCO1)C1CCCCC1.COc1cccc(OC)c1
|
COc1cc(OC)cc([C@@H](NC(=O)N(C)C2CCCCC2)c2nccn2C)c1
|
CN(C(=O)N[C@H]1C[C](c2nccn2C)CCO1)C1CCCCC1.COc1cccc(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C[C@@]&&CCO1",
"old_substring": "[C@H]79%10"
}
|
Can you make molecule COc1cc(OC)cc([C@@H](NC(=O)N(C)C2CCCCC2)c2nccn2C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(C(=O)N[C@@H]1C[C](c2nccn2C)CCO1)C1CCCCC1.COc1cccc(OC)c1
|
COc1cc(OC)cc([C@@H](NC(=O)N(C)C2CCCCC2)c2nccn2C)c1
|
CN(C(=O)N[C@@H]1C[C](c2nccn2C)CCO1)C1CCCCC1.COc1cccc(OC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&C[C@]&&CCO1",
"old_substring": "[C@H]79%10"
}
|
Can you make molecule O=C1[C@@H]2[C@H](C(=O)N1CN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)[C@H]1C=C[C@@H]2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cc(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@@H]3C2)c(-c2cccc(C(F)(F)F)c2)nc1C(=O)C(F)(F)F
|
O=C1[C@@H]2[C@H](C(=O)N1CN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)[C@H]1C=C[C@@H]2C1
|
N#Cc1cc(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@@H]3C2)c(-c2cccc(C(F)(F)F)c2)nc1C(=O)C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(C#N)c&nc1&",
"old_substring": "C6N45"
}
|
Can you make molecule O=C1[C@@H]2[C@H](C(=O)N1CN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)[C@H]1C=C[C@@H]2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(N/N=C\c1sc(C(=O)C(F)(F)F)nc1-c1cccc(C(F)(F)F)c1)N1C(=O)[C@@H]2[C@H](C1=O)[C@H]1C=C[C@@H]2C1
|
O=C1[C@@H]2[C@H](C(=O)N1CN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)[C@H]1C=C[C@@H]2C1
|
O=C(N/N=C\c1sc(C(=O)C(F)(F)F)nc1-c1cccc(C(F)(F)F)c1)N1C(=O)[C@@H]2[C@H](C1=O)[C@H]1C=C[C@@H]2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&N/N=C\\c1sc&nc1&",
"old_substring": "C6N45"
}
|
Can you make molecule O=C1[C@@H]2[C@H](C(=O)N1CN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)[C@H]1C=C[C@@H]2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(SN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)N1C(=O)[C@@H]2[C@H](C1=O)[C@H]1C=C[C@@H]2C1
|
O=C1[C@@H]2[C@H](C(=O)N1CN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)[C@H]1C=C[C@@H]2C1
|
O=C(SN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)N1C(=O)[C@@H]2[C@H](C1=O)[C@H]1C=C[C@@H]2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)SN&&",
"old_substring": "C6N45"
}
|
Can you make molecule O=C1[C@@H]2[C@H](C(=O)N1CN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)[C@H]1C=C[C@@H]2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@@H]3C2)nn(C(=O)C(F)(F)F)c1-c1cccc(C(F)(F)F)c1
|
O=C1[C@@H]2[C@H](C(=O)N1CN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)[C@H]1C=C[C@@H]2C1
|
Cc1c(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@@H]3C2)nn(C(=O)C(F)(F)F)c1-c1cccc(C(F)(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&nn&c1&",
"old_substring": "C6N45"
}
|
Can you make molecule O=C1[C@@H]2[C@H](C(=O)N1CN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)[C@H]1C=C[C@@H]2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@@H]3C2)sc(C(=O)C(F)(F)F)c1-c1cccc(C(F)(F)F)c1
|
O=C1[C@@H]2[C@H](C(=O)N1CN(C(=O)C(F)(F)F)c1cccc(C(F)(F)F)c1)[C@H]1C=C[C@@H]2C1
|
Cc1c(N2C(=O)[C@@H]3[C@H](C2=O)[C@H]2C=C[C@@H]3C2)sc(C(=O)C(F)(F)F)c1-c1cccc(C(F)(F)F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&sc&c1&",
"old_substring": "C6N45"
}
|
Can you make molecule CCNc1ncc(COc2cccc3ccccc23)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C)C(=S)Sc1ncc(COc2cccc3ccccc23)s1
|
CCNc1ncc(COc2cccc3ccccc23)s1
|
CCN(C)C(=S)Sc1ncc(COc2cccc3ccccc23)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N67"
}
|
Can you make molecule CCNc1ncc(COc2cccc3ccccc23)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cc(-c2ncc(COc3cccc4ccccc34)s2)c(N)o1
|
CCNc1ncc(COc2cccc3ccccc23)s1
|
CCc1cc(-c2ncc(COc3cccc4ccccc34)s2)c(N)o1
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1oc&cc1&",
"old_substring": "N67"
}
|
Can you make molecule CCNc1ncc(COc2cccc3ccccc23)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN1CCN=C1Sc1ncc(COc2cccc3ccccc23)s1
|
CCNc1ncc(COc2cccc3ccccc23)s1
|
CCN1CCN=C1Sc1ncc(COc2cccc3ccccc23)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N67"
}
|
Can you make molecule CCNc1ncc(COc2cccc3ccccc23)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCN1CCC(c2ncc(COc3cccc4ccccc34)s2)CC1
|
CCNc1ncc(COc2cccc3ccccc23)s1
|
CCCN1CCC(c2ncc(COc3cccc4ccccc34)s2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N67"
}
|
Can you make molecule CCNc1ncc(COc2cccc3ccccc23)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCc1cccc(-c2ncc(COc3cccc4ccccc34)s2)c1N
|
CCNc1ncc(COc2cccc3ccccc23)s1
|
CCc1cccc(-c2ncc(COc3cccc4ccccc34)s2)c1N
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&cccc1&",
"old_substring": "N67"
}
|
Can you make molecule Cc1noc(C)c1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(Cl)sc1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C
|
Cc1noc(C)c1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C
|
Cc1nc(Cl)sc1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nc(Cl)sc1&",
"old_substring": "Cc1noc(C)c17"
}
|
Can you make molecule Cc1noc(C)c1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(C=CCCNC(=O)c2c(C)nn(Cc3ccccc3)c2C)cs1
|
Cc1noc(C)c1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C
|
Cc1nc(C=CCCNC(=O)c2c(C)nn(Cc3ccccc3)c2C)cs1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nc(C=&)cs1",
"old_substring": "Cc1noc(C)c17"
}
|
Can you make molecule Cc1noc(C)c1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2)c(C)c1C(=O)NCCCc1c(C)oc(C)c1C
|
Cc1noc(C)c1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C
|
Cc1nn(Cc2ccccc2)c(C)c1C(=O)NCCCc1c(C)oc(C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1oc(C)c&c1C",
"old_substring": "Cc1noc(C)c17"
}
|
Can you make molecule Cc1noc(C)c1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nn(Cc2ccccc2)c(C)c1C(=O)NCCCc1c(C)oc(C)c1Br
|
Cc1noc(C)c1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C
|
Cc1nn(Cc2ccccc2)c(C)c1C(=O)NCCCc1c(C)oc(C)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1oc(C)c&c1Br",
"old_substring": "Cc1noc(C)c17"
}
|
Can you make molecule Cc1noc(C)c1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(C)c(C=CCCNC(=O)c2c(C)nn(Cc3ccccc3)c2C)s1
|
Cc1noc(C)c1CCCNC(=O)c1c(C)nn(Cc2ccccc2)c1C
|
Cc1nc(C)c(C=CCCNC(=O)c2c(C)nn(Cc3ccccc3)c2C)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1nc(C)c(C=&)s1",
"old_substring": "Cc1noc(C)c17"
}
|
Can you make molecule C[C@H]([NH2+]C1C[C@H](C)O[C@@H](C)C1)c1c[nH]c2cc(F)ccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CC([NH2+][C@H](CCl)CCCc2c[nH]c3cc(F)ccc23)C[C@H](C)O1
|
C[C@H]([NH2+]C1C[C@H](C)O[C@@H](C)C1)c1c[nH]c2cc(F)ccc12
|
C[C@H]1CC([NH2+][C@H](CCl)CCCc2c[nH]c3cc(F)ccc23)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]46C"
}
|
Can you make molecule C[C@H]([NH2+]C1C[C@H](C)O[C@@H](C)C1)c1c[nH]c2cc(F)ccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CC([NH2+][C@@H]2N=NC=C2CCc2c[nH]c3cc(F)ccc23)C[C@H](C)O1
|
C[C@H]([NH2+]C1C[C@H](C)O[C@@H](C)C1)c1c[nH]c2cc(F)ccc12
|
C[C@H]1CC([NH2+][C@@H]2N=NC=C2CCc2c[nH]c3cc(F)ccc23)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N=NC=C1CC&",
"old_substring": "[C@@H]46C"
}
|
Can you make molecule C[C@H]([NH2+]C1C[C@H](C)O[C@@H](C)C1)c1c[nH]c2cc(F)ccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CC([NH2+][C@@H]2CC[C@@H](c3c[nH]c4cc(F)ccc34)C2)C[C@H](C)O1
|
C[C@H]([NH2+]C1C[C@H](C)O[C@@H](C)C1)c1c[nH]c2cc(F)ccc12
|
C[C@H]1CC([NH2+][C@@H]2CC[C@@H](c3c[nH]c4cc(F)ccc34)C2)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]46C"
}
|
Can you make molecule C[C@H]([NH2+]C1C[C@H](C)O[C@@H](C)C1)c1c[nH]c2cc(F)ccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CC([NH2+][C@H](C)C(C)(C)Cc2c[nH]c3cc(F)ccc23)C[C@H](C)O1
|
C[C@H]([NH2+]C1C[C@H](C)O[C@@H](C)C1)c1c[nH]c2cc(F)ccc12
|
C[C@H]1CC([NH2+][C@H](C)C(C)(C)Cc2c[nH]c3cc(F)ccc23)C[C@H](C)O1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(C)C(C)(C)C&",
"old_substring": "[C@@H]46C"
}
|
Can you make molecule C[C@H]([NH2+]C1C[C@H](C)O[C@@H](C)C1)c1c[nH]c2cc(F)ccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@@H](CCc1c[nH]c2cc(F)ccc12)[NH2+]C1C[C@H](C)O[C@@H](C)C1
|
C[C@H]([NH2+]C1C[C@H](C)O[C@@H](C)C1)c1c[nH]c2cc(F)ccc12
|
CC[C@@H](CCc1c[nH]c2cc(F)ccc12)[NH2+]C1C[C@H](C)O[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC)CC&",
"old_substring": "[C@@H]46C"
}
|
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