prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule O=C(Cn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(/C=C/Sn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F
|
O=C(Cn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F
|
O=C(/C=C/Sn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O=C4C7"
}
|
Can you make molecule O=C(Cn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=C1CCC(n2cnc3nc(N4CCOCC4)ncc3c2=O)CC1)Nc1ccc(Cl)cc1F
|
O=C(Cn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F
|
O=C(NN=C1CCC(n2cnc3nc(N4CCOCC4)ncc3c2=O)CC1)Nc1ccc(Cl)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=C1CCC&CC1",
"old_substring": "O=C4C7"
}
|
Can you make molecule O=C(Cn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
C/C(=N\ONc1ccc(Cl)cc1F)C(=O)Sn1cnc2nc(N3CCOCC3)ncc2c1=O
|
O=C(Cn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F
|
C/C(=N\ONc1ccc(Cl)cc1F)C(=O)Sn1cnc2nc(N3CCOCC3)ncc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O&/N=C(\\C)C(=O)S&",
"old_substring": "O=C4C7"
}
|
Can you make molecule O=C(Cn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Nc1ccc(Cl)cc1F)C1=CC[C@H](n2cnc3nc(N4CCOCC4)ncc3c2=O)S1
|
O=C(Cn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F
|
O=C(Nc1ccc(Cl)cc1F)C1=CC[C@H](n2cnc3nc(N4CCOCC4)ncc3c2=O)S1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&C1=CC[C@H]&S1",
"old_substring": "O=C4C7"
}
|
Can you make molecule O=C(Cn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NN=Cc1ccc(-n2cnc3nc(N4CCOCC4)ncc3c2=O)cc1)Nc1ccc(Cl)cc1F
|
O=C(Cn1cnc2nc(N3CCOCC3)ncc2c1=O)Nc1ccc(Cl)cc1F
|
O=C(NN=Cc1ccc(-n2cnc3nc(N4CCOCC4)ncc3c2=O)cc1)Nc1ccc(Cl)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&NN=Cc1ccc&cc1",
"old_substring": "O=C4C7"
}
|
Can you make molecule C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#C)c3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C)c3C)cc2)c1
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#C)c3)cc2)c1
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C)c3C)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c19cccc(C#C)c1"
}
|
Can you make molecule C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#C)c3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#CCCCCO)c3)cc2)c1
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#C)c3)cc2)c1
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#CCCCCO)c3)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C#CCCCCO)c1",
"old_substring": "c19cccc(C#C)c1"
}
|
Can you make molecule C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#C)c3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(/C=C/Br)c3)cc2)c1
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#C)c3)cc2)c1
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(/C=C/Br)c3)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(/C=C/Br)c1",
"old_substring": "c19cccc(C#C)c1"
}
|
Can you make molecule C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#C)c3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3ccc(C)cc3Cl)cc2)c1
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#C)c3)cc2)c1
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3ccc(C)cc3Cl)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(C)cc1Cl",
"old_substring": "c19cccc(C#C)c1"
}
|
Can you make molecule C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#C)c3)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cc(C)c(F)c(C)c3)cc2)c1
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cccc(C#C)c3)cc2)c1
|
C#Cc1cccc(NC(=O)c2ccc(NC(=O)c3cc(C)c(F)c(C)c3)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&cc(C)c1F",
"old_substring": "c19cccc(C#C)c1"
}
|
Can you make molecule Cc1cc(OC(=O)[C@H](Cc2ccccc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(OC(=O)[C@H](Cc2ccccc2Cl)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl
|
Cc1cc(OC(=O)[C@H](Cc2ccccc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl
|
Cc1cc(OC(=O)[C@H](Cc2ccccc2Cl)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c17ccccc1"
}
|
Can you make molecule Cc1cc(OC(=O)[C@H](Cc2ccccc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(OC(=O)[C@H](Cc2ccc(I)cc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl
|
Cc1cc(OC(=O)[C@H](Cc2ccccc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl
|
Cc1cc(OC(=O)[C@H](Cc2ccc(I)cc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule Cc1cc(OC(=O)[C@H](Cc2ccccc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C[C@@H](C(=O)Oc2cc(C)c(Cl)c(C)c2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc1I
|
Cc1cc(OC(=O)[C@H](Cc2ccccc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl
|
Cc1ccc(C[C@@H](C(=O)Oc2cc(C)c(Cl)c(C)c2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c17ccccc1"
}
|
Can you make molecule Cc1cc(OC(=O)[C@H](Cc2ccccc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(OC(=O)[C@H](Cc2cccc(Br)c2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl
|
Cc1cc(OC(=O)[C@H](Cc2ccccc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl
|
Cc1cc(OC(=O)[C@H](Cc2cccc(Br)c2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c17ccccc1"
}
|
Can you make molecule Cc1cc(OC(=O)[C@H](Cc2ccccc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(C[C@@H](C(=O)Oc2cc(C)c(Cl)c(C)c2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)c1C
|
Cc1cc(OC(=O)[C@H](Cc2ccccc2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)cc(C)c1Cl
|
Cc1cccc(C[C@@H](C(=O)Oc2cc(C)c(Cl)c(C)c2)N2C(=O)[C@@H]3[C@@H]4C=C[C@@H]([C@@H]5C[C@H]45)[C@@H]3C2=O)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c17ccccc1"
}
|
Can you make molecule COc1cccc(C[C@@H](NCc2ncn(C)n2)c2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(C[C@@H](NCc2n[nH]c(Cl)n2)c2ccccc2)c1
|
COc1cccc(C[C@@H](NCc2ncn(C)n2)c2ccccc2)c1
|
COc1cccc(C[C@@H](NCc2n[nH]c(Cl)n2)c2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&n[nH]c(Cl)n1",
"old_substring": "c16ncn(C)n1"
}
|
Can you make molecule COc1cccc(C[C@@H](NCc2ncn(C)n2)c2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(C[C@@H](NCc2ncnc(Cl)c2C)c2ccccc2)c1
|
COc1cccc(C[C@@H](NCc2ncn(C)n2)c2ccccc2)c1
|
COc1cccc(C[C@@H](NCc2ncnc(Cl)c2C)c2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncnc(Cl)c1C",
"old_substring": "c16ncn(C)n1"
}
|
Can you make molecule COc1cccc(C[C@@H](NCc2ncn(C)n2)c2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(C[C@@H](NCc2nc(C)cs2)c2ccccc2)c1
|
COc1cccc(C[C@@H](NCc2ncn(C)n2)c2ccccc2)c1
|
COc1cccc(C[C@@H](NCc2nc(C)cs2)c2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc(C)cs1",
"old_substring": "c16ncn(C)n1"
}
|
Can you make molecule COc1cccc(C[C@@H](NCc2ncn(C)n2)c2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(C[C@@H](NCc2ncc(C)s2)c2ccccc2)c1
|
COc1cccc(C[C@@H](NCc2ncn(C)n2)c2ccccc2)c1
|
COc1cccc(C[C@@H](NCc2ncc(C)s2)c2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc(C)s1",
"old_substring": "c16ncn(C)n1"
}
|
Can you make molecule COc1cccc(C[C@@H](NCc2ncn(C)n2)c2ccccc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(C[C@@H](NCc2cn3nc(C)sc3n2)c2ccccc2)c1
|
COc1cccc(C[C@@H](NCc2ncn(C)n2)c2ccccc2)c1
|
COc1cccc(C[C@@H](NCc2cn3nc(C)sc3n2)c2ccccc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cn2nc(C)sc2n1",
"old_substring": "c16ncn(C)n1"
}
|
Can you make molecule CCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2C2CC(C)C2)cc1C
|
CCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O
|
Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2C2CC(C)C2)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC1CC&C1",
"old_substring": "CCC6"
}
|
Can you make molecule CCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2CCC(C)C)cc1C
|
CCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O
|
Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2CCC(C)C)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CCC6"
}
|
Can you make molecule CCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2CCCCBr)cc1C
|
CCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O
|
Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2CCCCBr)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CCC6"
}
|
Can you make molecule CCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O
|
CCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O
|
C=CCCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CCC6"
}
|
Can you make molecule CCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2CCCCCl)cc1C
|
CCCn1c(SCC(=O)Nc2ccc(C)c(C)c2)nc2ccccc2c1=O
|
Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2CCCCCl)cc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CCC6"
}
|
Can you make molecule COc1cccc(C(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(CC(=O)SNC(=S)Nc2ccc3c4c(cccc24)CC3)c1
|
COc1cccc(C(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1
|
COc1cccc(CC(=O)SNC(=S)Nc2ccc3c4c(cccc24)CC3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C58=O"
}
|
Can you make molecule COc1cccc(C(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(C(=O)CCCC(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1
|
COc1cccc(C(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1
|
COc1cccc(C(=O)CCCC(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C58=O"
}
|
Can you make molecule COc1cccc(C(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(C(C)(C)CC(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1
|
COc1cccc(C(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1
|
COc1cccc(C(C)(C)CC(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C58=O"
}
|
Can you make molecule COc1cccc(C(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc(C(C)(C)CCC(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1
|
COc1cccc(C(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1
|
COc1cccc(C(C)(C)CCC(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C58=O"
}
|
Can you make molecule COc1cccc(C(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc([C@H](C)C(=O)SNC(=S)Nc2ccc3c4c(cccc24)CC3)c1
|
COc1cccc(C(=O)NC(=S)Nc2ccc3c4c(cccc24)CC3)c1
|
COc1cccc([C@H](C)C(=O)SNC(=S)Nc2ccc3c4c(cccc24)CC3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C58=O"
}
|
Can you make molecule COc1ccc(O[C@H]2CC[C@@]([NH2+]C(C)C)(C(=O)[O-])C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(O[C@@H](CCC[NH2+]C(C)C)C(C)(C)C(=O)[O-])cc1
|
COc1ccc(O[C@H]2CC[C@@]([NH2+]C(C)C)(C(=O)[O-])C2)cc1
|
COc1ccc(O[C@@H](CCC[NH2+]C(C)C)C(C)(C)C(=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CCC&)C&(C)C",
"old_substring": "[C@H]13CC[C@@]68C1"
}
|
Can you make molecule COc1ccc(O[C@H]2CC[C@@]([NH2+]C(C)C)(C(=O)[O-])C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(OC2Cc3cc([NH2+]C(C)C)c(C(=O)[O-])cc3C2)cc1
|
COc1ccc(O[C@H]2CC[C@@]([NH2+]C(C)C)(C(=O)[O-])C2)cc1
|
COc1ccc(OC2Cc3cc([NH2+]C(C)C)c(C(=O)[O-])cc3C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&Cc2cc&c&cc2C1",
"old_substring": "[C@H]13CC[C@@]68C1"
}
|
Can you make molecule COc1ccc(O[C@H]2CC[C@@]([NH2+]C(C)C)(C(=O)[O-])C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Oc2sc([NH2+]C(C)C)c(C(=O)[O-])c2C)cc1
|
COc1ccc(O[C@H]2CC[C@@]([NH2+]C(C)C)(C(=O)[O-])C2)cc1
|
COc1ccc(Oc2sc([NH2+]C(C)C)c(C(=O)[O-])c2C)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&sc&c1&",
"old_substring": "[C@H]13CC[C@@]68C1"
}
|
Can you make molecule COc1ccc(O[C@H]2CC[C@@]([NH2+]C(C)C)(C(=O)[O-])C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Oc2cc([NH2+]C(C)C)c3cc(C(=O)[O-])[nH]c3c2)cc1
|
COc1ccc(O[C@H]2CC[C@@]([NH2+]C(C)C)(C(=O)[O-])C2)cc1
|
COc1ccc(Oc2cc([NH2+]C(C)C)c3cc(C(=O)[O-])[nH]c3c2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c2cc&[nH]c2c1",
"old_substring": "[C@H]13CC[C@@]68C1"
}
|
Can you make molecule COc1ccc(O[C@H]2CC[C@@]([NH2+]C(C)C)(C(=O)[O-])C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(Oc2cc(Cl)c(C(=O)[O-])c([NH2+]C(C)C)c2)cc1
|
COc1ccc(O[C@H]2CC[C@@]([NH2+]C(C)C)(C(=O)[O-])C2)cc1
|
COc1ccc(Oc2cc(Cl)c(C(=O)[O-])c([NH2+]C(C)C)c2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&c&c(Cl)c1",
"old_substring": "[C@H]13CC[C@@]68C1"
}
|
Can you make molecule Cc1ccc(Oc2ncccc2CNC(=O)CCC(=O)N(C)C)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Oc2nccc(CNC(=O)CCC(=O)N(C)C)c2I)cn1
|
Cc1ccc(Oc2ncccc2CNC(=O)CCC(=O)N(C)C)cn1
|
Cc1ccc(Oc2nccc(CNC(=O)CCC(=O)N(C)C)c2I)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nccc&c1I",
"old_substring": "c15ncccc18"
}
|
Can you make molecule Cc1ccc(Oc2ncccc2CNC(=O)CCC(=O)N(C)C)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Oc2ncc(CNC(=O)CCC(=O)N(C)C)cc2Cl)cn1
|
Cc1ccc(Oc2ncccc2CNC(=O)CCC(=O)N(C)C)cn1
|
Cc1ccc(Oc2ncc(CNC(=O)CCC(=O)N(C)C)cc2Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc&cc1Cl",
"old_substring": "c15ncccc18"
}
|
Can you make molecule Cc1ccc(Oc2ncccc2CNC(=O)CCC(=O)N(C)C)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Oc2nc(CNC(=O)CCC(=O)N(C)C)ccc2Cl)cn1
|
Cc1ccc(Oc2ncccc2CNC(=O)CCC(=O)N(C)C)cn1
|
Cc1ccc(Oc2nc(CNC(=O)CCC(=O)N(C)C)ccc2Cl)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc&ccc1Cl",
"old_substring": "c15ncccc18"
}
|
Can you make molecule Cc1ccc(Oc2ncccc2CNC(=O)CCC(=O)N(C)C)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Oc2nc(CNC(=O)CCC(=O)N(C)C)ccc2Br)cn1
|
Cc1ccc(Oc2ncccc2CNC(=O)CCC(=O)N(C)C)cn1
|
Cc1ccc(Oc2nc(CNC(=O)CCC(=O)N(C)C)ccc2Br)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nc&ccc1Br",
"old_substring": "c15ncccc18"
}
|
Can you make molecule Cc1ccc(Oc2ncccc2CNC(=O)CCC(=O)N(C)C)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(Oc2ncc(C)c(CNC(=O)CCC(=O)N(C)C)c2C)cn1
|
Cc1ccc(Oc2ncccc2CNC(=O)CCC(=O)N(C)C)cn1
|
Cc1ccc(Oc2ncc(C)c(CNC(=O)CCC(=O)N(C)C)c2C)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ncc(C)c&c1C",
"old_substring": "c15ncccc18"
}
|
Can you make molecule CN(Cc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CCCCc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1
|
CN(Cc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1
|
CN(CCCCc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC&",
"old_substring": "C35"
}
|
Can you make molecule CN(Cc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(CCCCCc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1
|
CN(Cc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1
|
CN(CCCCCc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C35"
}
|
Can you make molecule CN(Cc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccco1)C1CC(c2nc3c(cnn3C)c(=O)[nH]2)C1
|
CN(Cc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1
|
CN(Cc1ccco1)C1CC(c2nc3c(cnn3C)c(=O)[nH]2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CC&C1",
"old_substring": "C35"
}
|
Can you make molecule CN(Cc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccco1)OC(=S)Sc1nc2c(cnn2C)c(=O)[nH]1
|
CN(Cc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1
|
CN(Cc1ccco1)OC(=S)Sc1nc2c(cnn2C)c(=O)[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "C35"
}
|
Can you make molecule CN(Cc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1 less soluble in water? The output molecule should be similar to the input molecule.
|
CN(Cc1ccco1)SC(=S)Nc1nc2c(cnn2C)c(=O)[nH]1
|
CN(Cc1nc2c(cnn2C)c(=O)[nH]1)Cc1ccco1
|
CN(Cc1ccco1)SC(=S)Nc1nc2c(cnn2C)c(=O)[nH]1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=S)N&",
"old_substring": "C35"
}
|
Can you make molecule C[C@@H]1CCc2nc3ccccc3c(C(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCc2nc3ccccc3c(CC(=O)SOCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
|
C[C@@H]1CCc2nc3ccccc3c(C(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
|
C[C@@H]1CCc2nc3ccccc3c(CC(=O)SOCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C48=O"
}
|
Can you make molecule C[C@@H]1CCc2nc3ccccc3c(C(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCc2nc3ccccc3c(C(=O)CCCC(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
|
C[C@@H]1CCc2nc3ccccc3c(C(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
|
C[C@@H]1CCc2nc3ccccc3c(C(=O)CCCC(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C48=O"
}
|
Can you make molecule C[C@@H]1CCc2nc3ccccc3c(C(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCc2nc3ccccc3c(C(C)(C)CC(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
|
C[C@@H]1CCc2nc3ccccc3c(C(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
|
C[C@@H]1CCc2nc3ccccc3c(C(C)(C)CC(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C48=O"
}
|
Can you make molecule C[C@@H]1CCc2nc3ccccc3c(C(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCc2nc3ccccc3c(C(C)(C)CCC(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
|
C[C@@H]1CCc2nc3ccccc3c(C(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
|
C[C@@H]1CCc2nc3ccccc3c(C(C)(C)CCC(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C48=O"
}
|
Can you make molecule C[C@@H]1CCc2nc3ccccc3c(C(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H]1CCc2nc3ccccc3c([C@H](C)C(=O)SOCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
|
C[C@@H]1CCc2nc3ccccc3c(C(=O)OCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
|
C[C@@H]1CCc2nc3ccccc3c([C@H](C)C(=O)SOCC(=O)N[C@H]3CCS(=O)(=O)C3)c2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C48=O"
}
|
Can you make molecule C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](CC(=O)SNCCC)C2)c1=S
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](CC(=O)SNCCC)C2)c1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](CC(=C=O)CNCCC)C2)c1=S
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](CC(=C=O)CNCCC)C2)c1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(=C=O)C&",
"old_substring": "C35=O"
}
|
Can you make molecule C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)CCCC(=O)NCCC)C2)c1=S
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)CCCC(=O)NCCC)C2)c1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C35=O"
}
|
Can you make molecule C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(C)(C)CC(=O)NCCC)C2)c1=S
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(C)(C)CC(=O)NCCC)C2)c1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C35=O"
}
|
Can you make molecule C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](CCC[S@@+]([O-])CNCCC)C2)c1=S
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](C(=O)NCCC)C2)c1=S
|
C=CCn1c(C)nn(C[NH+]2CCC[C@H](CCC[S@@+]([O-])CNCCC)C2)c1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C35=O"
}
|
Can you make molecule C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](C)Sc1ccc([N+](=O)[O-])cc1
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O
|
CC(=O)[C@H]1Cc2ccccc2CN1C(=O)[C@H](C)Sc1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)=O",
"old_substring": "C5(N)=O"
}
|
Can you make molecule C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1CCCCC(N)=O
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1CCCCC(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(N)=O",
"old_substring": "C5(N)=O"
}
|
Can you make molecule C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C/C(N)=N\O
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C/C(N)=N\O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&/C(N)=N\\O",
"old_substring": "C5(N)=O"
}
|
Can you make molecule C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1CC/C(N)=N/O
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1CC/C(N)=N/O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C/C(N)=N/O",
"old_substring": "C5(N)=O"
}
|
Can you make molecule C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1CC/C(N)=N\O
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O
|
C[C@H](Sc1ccc([N+](=O)[O-])cc1)C(=O)N1Cc2ccccc2C[C@@H]1CC/C(N)=N\O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C/C(N)=N\\O",
"old_substring": "C5(N)=O"
}
|
Can you make molecule CCN(C[C@@H]1CCOC1)C(=O)c1ccnc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C[C@@H]1CCOC1)SC(=O)Cc1ccnc(Cl)c1
|
CCN(C[C@@H]1CCOC1)C(=O)c1ccnc(Cl)c1
|
CCN(C[C@@H]1CCOC1)SC(=O)Cc1ccnc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C25=O"
}
|
Can you make molecule CCN(C[C@@H]1CCOC1)C(=O)c1ccnc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C[C@@H]1CCOC1)C(=O)CCCC(=O)c1ccnc(Cl)c1
|
CCN(C[C@@H]1CCOC1)C(=O)c1ccnc(Cl)c1
|
CCN(C[C@@H]1CCOC1)C(=O)CCCC(=O)c1ccnc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C25=O"
}
|
Can you make molecule CCN(C[C@@H]1CCOC1)C(=O)c1ccnc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C[C@@H]1CCOC1)C(=O)CC(C)(C)c1ccnc(Cl)c1
|
CCN(C[C@@H]1CCOC1)C(=O)c1ccnc(Cl)c1
|
CCN(C[C@@H]1CCOC1)C(=O)CC(C)(C)c1ccnc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C25=O"
}
|
Can you make molecule CCN(C[C@@H]1CCOC1)C(=O)c1ccnc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C[C@@H]1CCOC1)C(=O)CCC(C)(C)c1ccnc(Cl)c1
|
CCN(C[C@@H]1CCOC1)C(=O)c1ccnc(Cl)c1
|
CCN(C[C@@H]1CCOC1)C(=O)CCC(C)(C)c1ccnc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C25=O"
}
|
Can you make molecule CCN(C[C@@H]1CCOC1)C(=O)c1ccnc(Cl)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCN(C[C@@H]1CCOC1)SC(=O)[C@@H](C)c1ccnc(Cl)c1
|
CCN(C[C@@H]1CCOC1)C(=O)c1ccnc(Cl)c1
|
CCN(C[C@@H]1CCOC1)SC(=O)[C@@H](C)c1ccnc(Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C25=O"
}
|
Can you make molecule CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2C=C2CCC2)cc1
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CC2)cc1
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2C=C2CCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCC1",
"old_substring": "C14CC1"
}
|
Can you make molecule CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CCCCC2)cc1
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CC2)cc1
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CCCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCC1",
"old_substring": "C14CC1"
}
|
Can you make molecule CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2C=C2CCCC2)cc1
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CC2)cc1
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2C=C2CCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=&CCCC1",
"old_substring": "C14CC1"
}
|
Can you make molecule CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2SCCCS2)cc1
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CC2)cc1
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2SCCCS2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "C14CC1"
}
|
Can you make molecule CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2SCSCS2)cc1
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2CC2)cc1
|
CC(C)(C)c1ccc([C@@]2(C)C[NH+]=C(N)N2CC2SCSCS2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCSCS1",
"old_substring": "C14CC1"
}
|
Can you make molecule N/C(=N/OCc1ccc(Br)cc1F)[C@@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
N/C(=N/OCc1ccc(Br)cc1Br)[C@@H]1CCOC1
|
N/C(=N/OCc1ccc(Br)cc1F)[C@@H]1CCOC1
|
N/C(=N/OCc1ccc(Br)cc1Br)[C@@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)cc1Br",
"old_substring": "c13ccc(Br)cc1F"
}
|
Can you make molecule N/C(=N/OCc1ccc(Br)cc1F)[C@@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
N/C(=N/OCc1ccc(Br)c(Cl)c1F)[C@@H]1CCOC1
|
N/C(=N/OCc1ccc(Br)cc1F)[C@@H]1CCOC1
|
N/C(=N/OCc1ccc(Br)c(Cl)c1F)[C@@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)c(Cl)c1F",
"old_substring": "c13ccc(Br)cc1F"
}
|
Can you make molecule N/C(=N/OCc1ccc(Br)cc1F)[C@@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=CO/N=C(/N)[C@@H]1CCOC1)c1ccc(Br)cc1
|
N/C(=N/OCc1ccc(Br)cc1F)[C@@H]1CCOC1
|
CC(=CO/N=C(/N)[C@@H]1CCOC1)c1ccc(Br)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC=&c1ccc(Br)cc1",
"old_substring": "c13ccc(Br)cc1F"
}
|
Can you make molecule N/C(=N/OCc1ccc(Br)cc1F)[C@@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
N/C(=N/OCc1cc(Br)ccc1Cl)[C@@H]1CCOC1
|
N/C(=N/OCc1ccc(Br)cc1F)[C@@H]1CCOC1
|
N/C(=N/OCc1cc(Br)ccc1Cl)[C@@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)ccc1Cl",
"old_substring": "c13ccc(Br)cc1F"
}
|
Can you make molecule N/C(=N/OCc1ccc(Br)cc1F)[C@@H]1CCOC1 less soluble in water? The output molecule should be similar to the input molecule.
|
N/C(=N/OCc1cc(Br)ccc1Br)[C@@H]1CCOC1
|
N/C(=N/OCc1ccc(Br)cc1F)[C@@H]1CCOC1
|
N/C(=N/OCc1cc(Br)ccc1Br)[C@@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)ccc1Br",
"old_substring": "c13ccc(Br)cc1F"
}
|
Can you make molecule COc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1
|
COc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1
|
COCc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1
|
COc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1
|
COCSc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(SC(C)=O)cc1[C@@H]1C2=C(CC(C)(C)CC2=O)Nc2[nH]c(-c3ccccc3)nc(=O)c21
|
COc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1
|
COc1ccc(SC(C)=O)cc1[C@@H]1C2=C(CC(C)(C)CC2=O)Nc2[nH]c(-c3ccccc3)nc(=O)c21
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)CS)cc1[C@@H]1C2=C(CC(C)(C)CC2=O)Nc2[nH]c(-c3ccccc3)nc(=O)c21
|
COc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1
|
COc1ccc(C(=O)CS)cc1[C@@H]1C2=C(CC(C)(C)CC2=O)Nc2[nH]c(-c3ccccc3)nc(=O)c21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(C(=O)CI)cc1[C@@H]1C2=C(CC(C)(C)CC2=O)Nc2[nH]c(-c3ccccc3)nc(=O)c21
|
COc1ccc(OC)c([C@@H]2C3=C(CC(C)(C)CC3=O)Nc3[nH]c(-c4ccccc4)nc(=O)c32)c1
|
COc1ccc(C(=O)CI)cc1[C@@H]1C2=C(CC(C)(C)CC2=O)Nc2[nH]c(-c3ccccc3)nc(=O)c21
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO5"
}
|
Can you make molecule CCOc1ccccc1-c1cccc(C(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1-c1cccc(CC(=O)SN[C@@H]2CCC[C@@H](C(N)=O)C2)c1
|
CCOc1ccccc1-c1cccc(C(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1
|
CCOc1ccccc1-c1cccc(CC(=O)SN[C@@H]2CCC[C@@H](C(N)=O)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C38=O"
}
|
Can you make molecule CCOc1ccccc1-c1cccc(C(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1-c1cccc(C(=O)CCCC(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1
|
CCOc1ccccc1-c1cccc(C(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1
|
CCOc1ccccc1-c1cccc(C(=O)CCCC(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C38=O"
}
|
Can you make molecule CCOc1ccccc1-c1cccc(C(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1-c1cccc(C(C)(C)CC(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1
|
CCOc1ccccc1-c1cccc(C(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1
|
CCOc1ccccc1-c1cccc(C(C)(C)CC(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C38=O"
}
|
Can you make molecule CCOc1ccccc1-c1cccc(C(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1-c1cccc(C(C)(C)CCC(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1
|
CCOc1ccccc1-c1cccc(C(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1
|
CCOc1ccccc1-c1cccc(C(C)(C)CCC(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C38=O"
}
|
Can you make molecule CCOc1ccccc1-c1cccc(C(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCOc1ccccc1-c1cccc([C@H](C)C(=O)SN[C@@H]2CCC[C@@H](C(N)=O)C2)c1
|
CCOc1ccccc1-c1cccc(C(=O)N[C@@H]2CCC[C@@H](C(N)=O)C2)c1
|
CCOc1ccccc1-c1cccc([C@H](C)C(=O)SN[C@@H]2CCC[C@@H](C(N)=O)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C38=O"
}
|
Can you make molecule CC(C)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(Cc1ccc(F)cc1Br)C[NH+]1CCCCCC1
|
CC(C)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1
|
CC(C)(Cc1ccc(F)cc1Br)C[NH+]1CCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C&)C&",
"old_substring": "CC2(C)C(=O)C3"
}
|
Can you make molecule CC(C)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1
|
CC(C)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1
|
CCC(CC)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "CC2(C)C(=O)C3"
}
|
Can you make molecule CC(C)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)[NH+]1CCCCCC1)c1ccc(F)cc1Br
|
CC(C)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1
|
CC(C)(CCC(=O)[NH+]1CCCCCC1)c1ccc(F)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "CC2(C)C(=O)C3"
}
|
Can you make molecule CC(C)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(C(=O)CCc1ccc(F)cc1Br)[NH+]1CCCCCC1
|
CC(C)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1
|
CCC(CC)(C(=O)CCc1ccc(F)cc1Br)[NH+]1CCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "CC2(C)C(=O)C3"
}
|
Can you make molecule CC(C)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCCc1ccc(F)cc1Br)C(=O)[NH+]1CCCCCC1
|
CC(C)(C(=O)Cc1ccc(F)cc1Br)[NH+]1CCCCCC1
|
CC(C)(CCCc1ccc(F)cc1Br)C(=O)[NH+]1CCCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(C)CCC&",
"old_substring": "CC2(C)C(=O)C3"
}
|
Can you make molecule O=c1nc(SCc2ccc(C(F)(F)F)cc2)c2c(n1C[C@H]1CCCO1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1nc(SCc2ccc(C(F)(F)F)cc2I)c2c(n1C[C@H]1CCCO1)CCCC2
|
O=c1nc(SCc2ccc(C(F)(F)F)cc2)c2c(n1C[C@H]1CCCO1)CCCC2
|
O=c1nc(SCc2ccc(C(F)(F)F)cc2I)c2c(n1C[C@H]1CCCO1)CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c16ccc7cc1"
}
|
Can you make molecule O=c1nc(SCc2ccc(C(F)(F)F)cc2)c2c(n1C[C@H]1CCCO1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1nc(SCc2cc(C(F)(F)F)ccc2Br)c2c(n1C[C@H]1CCCO1)CCCC2
|
O=c1nc(SCc2ccc(C(F)(F)F)cc2)c2c(n1C[C@H]1CCCO1)CCCC2
|
O=c1nc(SCc2cc(C(F)(F)F)ccc2Br)c2c(n1C[C@H]1CCCO1)CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c16ccc7cc1"
}
|
Can you make molecule O=c1nc(SCc2ccc(C(F)(F)F)cc2)c2c(n1C[C@H]1CCCO1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1nc(SCc2ccc(C(F)(F)F)cc2Cl)c2c(n1C[C@H]1CCCO1)CCCC2
|
O=c1nc(SCc2ccc(C(F)(F)F)cc2)c2c(n1C[C@H]1CCCO1)CCCC2
|
O=c1nc(SCc2ccc(C(F)(F)F)cc2Cl)c2c(n1C[C@H]1CCCO1)CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c16ccc7cc1"
}
|
Can you make molecule O=c1nc(SCc2ccc(C(F)(F)F)cc2)c2c(n1C[C@H]1CCCO1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1nc(SCc2cccc(C(F)(F)F)c2Br)c2c(n1C[C@H]1CCCO1)CCCC2
|
O=c1nc(SCc2ccc(C(F)(F)F)cc2)c2c(n1C[C@H]1CCCO1)CCCC2
|
O=c1nc(SCc2cccc(C(F)(F)F)c2Br)c2c(n1C[C@H]1CCCO1)CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c16ccc7cc1"
}
|
Can you make molecule O=c1nc(SCc2ccc(C(F)(F)F)cc2)c2c(n1C[C@H]1CCCO1)CCCC2 less soluble in water? The output molecule should be similar to the input molecule.
|
O=c1nc(SCc2cccc(C(F)(F)F)c2Cl)c2c(n1C[C@H]1CCCO1)CCCC2
|
O=c1nc(SCc2ccc(C(F)(F)F)cc2)c2c(n1C[C@H]1CCCO1)CCCC2
|
O=c1nc(SCc2cccc(C(F)(F)F)c2Cl)c2c(n1C[C@H]1CCCO1)CCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c16ccc7cc1"
}
|
Can you make molecule Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CC3)OCCO4)[C@H](c3ccccc3Cl)C2)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CCC4)C3)[C@H](c3ccccc3Cl)C2)c(C)c1
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CC3)OCCO4)[C@H](c3ccccc3Cl)C2)c(C)c1
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CCC4)C3)[C@H](c3ccccc3Cl)C2)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCC2(CCC2)C1",
"old_substring": "[NH+]15CCC2(CC1)OCCO2"
}
|
Can you make molecule Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CC3)OCCO4)[C@H](c3ccccc3Cl)C2)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CC4(CCCC4)C3)[C@H](c3ccccc3Cl)C2)c(C)c1
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CC3)OCCO4)[C@H](c3ccccc3Cl)C2)c(C)c1
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CC4(CCCC4)C3)[C@H](c3ccccc3Cl)C2)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC2(CCCC2)C1",
"old_substring": "[NH+]15CCC2(CC1)OCCO2"
}
|
Can you make molecule Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CC3)OCCO4)[C@H](c3ccccc3Cl)C2)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CC4(CCC4)C3)[C@H](c3ccccc3Cl)C2)c(C)c1
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CC3)OCCO4)[C@H](c3ccccc3Cl)C2)c(C)c1
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CC4(CCC4)C3)[C@H](c3ccccc3Cl)C2)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CC2(CCC2)C1",
"old_substring": "[NH+]15CCC2(CC1)OCCO2"
}
|
Can you make molecule Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CC3)OCCO4)[C@H](c3ccccc3Cl)C2)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CCCCCCC3)[C@H](c3ccccc3Cl)C2)c(C)c1
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CC3)OCCO4)[C@H](c3ccccc3Cl)C2)c(C)c1
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CCCCCCC3)[C@H](c3ccccc3Cl)C2)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCCCCCC1",
"old_substring": "[NH+]15CCC2(CC1)OCCO2"
}
|
Can you make molecule Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CC3)OCCO4)[C@H](c3ccccc3Cl)C2)c(C)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CCCC3(C)C)[C@H](c3ccccc3Cl)C2)c(C)c1
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CCC4(CC3)OCCO4)[C@H](c3ccccc3Cl)C2)c(C)c1
|
Cc1ccc(C2=NN(C(=O)C[NH+]3CCCC3(C)C)[C@H](c3ccccc3Cl)C2)c(C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[NH+]1&CCCC1(C)C",
"old_substring": "[NH+]15CCC2(CC1)OCCO2"
}
|
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