prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4)n3)CCO2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4Cl)n3)CCO2)c1
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4)n3)CCO2)c1
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4Cl)n3)CCO2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c16ccc(F)cc1"
}
|
Can you make molecule Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4)n3)CCO2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4Br)n3)CCO2)c1
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4)n3)CCO2)c1
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4Br)n3)CCO2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Br",
"old_substring": "c16ccc(F)cc1"
}
|
Can you make molecule Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4)n3)CCO2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)c(Cl)c4)n3)CCO2)c1
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4)n3)CCO2)c1
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)c(Cl)c4)n3)CCO2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)c(Cl)c1",
"old_substring": "c16ccc(F)cc1"
}
|
Can you make molecule Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4)n3)CCO2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(I)cc4F)n3)CCO2)c1
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4)n3)CCO2)c1
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(I)cc4F)n3)CCO2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1F",
"old_substring": "c16ccc(F)cc1"
}
|
Can you make molecule Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4)n3)CCO2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4cc5c(F)cccc5s4)n3)CCO2)c1
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4ccc(F)cc4)n3)CCO2)c1
|
Oc1cccc([C@@H]2CN(c3nccc(Oc4cc5c(F)cccc5s4)n3)CCO2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2c(F)cccc2s1",
"old_substring": "c16ccc(F)cc1"
}
|
Can you make molecule COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1I
|
COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1
|
COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c15ccc9cc1"
}
|
Can you make molecule COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)ccc1Br
|
COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1
|
COc1cc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)ccc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c15ccc9cc1"
}
|
Can you make molecule COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1Cl
|
COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1
|
COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c15ccc9cc1"
}
|
Can you make molecule COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)c1Br
|
COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1
|
COc1cccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c15ccc9cc1"
}
|
Can you make molecule COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1cccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)c1Cl
|
COc1ccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)cc1
|
COc1cccc([C@H](CNC(=O)c2cccc3ccccc23)[NH+]2CCCC2)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c15ccc9cc1"
}
|
Can you make molecule CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)COc1ccc(C3SCCCS3)cc1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NSC(=O)COc1ccc(C3SCCCS3)cc1)C2
|
CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)COc1ccc(C3SCCCS3)cc1)C2
|
CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NSC(=O)COc1ccc(C3SCCCS3)cc1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C4(=O)C5"
}
|
Can you make molecule CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)COc1ccc(C3SCCCS3)cc1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)CCCC(=O)Oc1ccc(C3SCCCS3)cc1)C2
|
CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)COc1ccc(C3SCCCS3)cc1)C2
|
CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)CCCC(=O)Oc1ccc(C3SCCCS3)cc1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C4(=O)C5"
}
|
Can you make molecule CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)COc1ccc(C3SCCCS3)cc1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C)Oc1ccc(C2SCCCS2)cc1
|
CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)COc1ccc(C3SCCCS3)cc1)C2
|
CC(C)(CC(=O)N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C)Oc1ccc(C2SCCCS2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C4(=O)C5"
}
|
Can you make molecule CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)COc1ccc(C3SCCCS3)cc1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC[S@+]([O-])CCCOc1ccc(C3SCCCS3)cc1)C2
|
CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)COc1ccc(C3SCCCS3)cc1)C2
|
CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC[S@+]([O-])CCCOc1ccc(C3SCCCS3)cc1)C2
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C4(=O)C5"
}
|
Can you make molecule CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)COc1ccc(C3SCCCS3)cc1)C2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C)Oc1ccc(C2SCCCS2)cc1
|
CC1(C)[C@@H]2CC[C@@]1(C)[C@H](NC(=O)COc1ccc(C3SCCCS3)cc1)C2
|
CC(C)(CCC(=O)N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C)Oc1ccc(C2SCCCS2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C4(=O)C5"
}
|
Can you make molecule Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCC3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCCCC3)c12
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCC3)c12
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCCCC3)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCC1",
"old_substring": "N15CCCCC1"
}
|
Can you make molecule Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCC3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCCCCC3)c12
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCC3)c12
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCCCCC3)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCCC1",
"old_substring": "N15CCCCC1"
}
|
Can you make molecule Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCC3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCC(C)(C)C3)c12
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCC3)c12
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCC(C)(C)C3)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC(C)(C)C1",
"old_substring": "N15CCCCC1"
}
|
Can you make molecule Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCC3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCC(C)(C)CC3)c12
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCC3)c12
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCC(C)(C)CC3)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC(C)(C)CC1",
"old_substring": "N15CCCCC1"
}
|
Can you make molecule Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCC3)c12 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CC4(CCCCC4)C3)c12
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CCCCC3)c12
|
Cc1c(C)n(-c2ccccc2)c2nc(C(=O)Nc3ccc(F)cc3)nc(N3CC4(CCCCC4)C3)c12
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC2(CCCCC2)C1",
"old_substring": "N15CCCCC1"
}
|
Can you make molecule CC(C)C(=O)Nc1cccc(NC(=O)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)Nc1cccc(NC(=O)CCCC(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
|
CC(C)C(=O)Nc1cccc(NC(=O)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
|
CC(C)C(=O)Nc1cccc(NC(=O)CCCC(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C5(=O)C6=O"
}
|
Can you make molecule CC(C)C(=O)Nc1cccc(NC(=O)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)Nc1cccc(NC(=O)CCC(=O)CNCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
|
CC(C)C(=O)Nc1cccc(NC(=O)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
|
CC(C)C(=O)Nc1cccc(NC(=O)CCC(=O)CNCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC(=O)C&",
"old_substring": "C5(=O)C6=O"
}
|
Can you make molecule CC(C)C(=O)Nc1cccc(NC(=O)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)Nc1cccc(NC[S@+]([O-])CCC(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
|
CC(C)C(=O)Nc1cccc(NC(=O)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
|
CC(C)C(=O)Nc1cccc(NC[S@+]([O-])CCC(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&=O",
"old_substring": "C5(=O)C6=O"
}
|
Can you make molecule CC(C)C(=O)Nc1cccc(NC(=O)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)Nc1cccc(NC(=O)CCCS(=O)(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
|
CC(C)C(=O)Nc1cccc(NC(=O)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
|
CC(C)C(=O)Nc1cccc(NC(=O)CCCS(=O)(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCS&(=O)=O",
"old_substring": "C5(=O)C6=O"
}
|
Can you make molecule CC(C)C(=O)Nc1cccc(NC(=O)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)Nc1cccc(NC(=O)C(C)(F)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
|
CC(C)C(=O)Nc1cccc(NC(=O)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
|
CC(C)C(=O)Nc1cccc(NC(=O)C(C)(F)C(=O)NCC[C@H]2C[C@H]3CC[C@@H]2C3)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C(C)(F)C&=O",
"old_substring": "C5(=O)C6=O"
}
|
Can you make molecule COc1ccc(CNC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CNSC(=O)Cc2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
|
COc1ccc(CNC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
|
COc1ccc(CNSC(=O)Cc2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C48=O"
}
|
Can you make molecule COc1ccc(CNC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CNC(=O)CCCC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
|
COc1ccc(CNC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
|
COc1ccc(CNC(=O)CCCC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C48=O"
}
|
Can you make molecule COc1ccc(CNC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CNC(=O)CC(C)(C)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
|
COc1ccc(CNC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
|
COc1ccc(CNC(=O)CC(C)(C)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C48=O"
}
|
Can you make molecule COc1ccc(CNC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CNC(=O)CCC(C)(C)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
|
COc1ccc(CNC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
|
COc1ccc(CNC(=O)CCC(C)(C)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C48=O"
}
|
Can you make molecule COc1ccc(CNC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc(CNSC(=O)[C@@H](C)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
|
COc1ccc(CNC(=O)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
|
COc1ccc(CNSC(=O)[C@@H](C)c2cc(N3C(=O)C(C)(C)CS3(=O)=O)ccc2Cl)cc1OC
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C48=O"
}
|
Can you make molecule CC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CO)=Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
|
CC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
|
CCC(CO)=Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&CO",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
|
CC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
|
CCCC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&=O",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)SNc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
|
CC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
|
CC(=O)SNc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
|
CC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
|
CCCCC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CC3=O"
}
|
Can you make molecule CC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C=O)=Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
|
CC(=O)Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
|
CCC(C=O)=Nc1cccc(NC(=O)CCc2c(C)[nH]c(=S)[nH]c2=O)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&C=O",
"old_substring": "CC3=O"
}
|
Can you make molecule COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1Cl
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c15ccccc1"
}
|
Can you make molecule COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccc(I)cc1
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccc(I)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccc(C)c(I)c1
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccc(C)c(I)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c15ccccc1"
}
|
Can you make molecule COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1cccc(Br)c1
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1cccc(Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c15ccccc1"
}
|
Can you make molecule COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1cccc(C)c1C
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1ccccc1
|
COc1ccccc1[C@H]1CCCN1C(=O)[C@@H](C)CCOc1cccc(C)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c15ccccc1"
}
|
Can you make molecule CCNc1ncc(COCC2CCCCC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNc1ncc(COCC2CCCCCCC2)s1
|
CCNc1ncc(COCC2CCCCC2)s1
|
CCNc1ncc(COCC2CCCCCCC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCCC1",
"old_substring": "C18CCCCC1"
}
|
Can you make molecule CCNc1ncc(COCC2CCCCC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNc1ncc(COCSC2=CCCCCC2)s1
|
CCNc1ncc(COCC2CCCCC2)s1
|
CCNc1ncc(COCSC2=CCCCCC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1=C(S&)CCCCC1",
"old_substring": "C18CCCCC1"
}
|
Can you make molecule CCNc1ncc(COCC2CCCCC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNc1ncc(COC=CC2CCCCC2)s1
|
CCNc1ncc(COCC2CCCCC2)s1
|
CCNc1ncc(COC=CC2CCCCC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&C1CCCCC1",
"old_substring": "C18CCCCC1"
}
|
Can you make molecule CCNc1ncc(COCC2CCCCC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNc1ncc(COCC2CCCCCCCCCCC2)s1
|
CCNc1ncc(COCC2CCCCC2)s1
|
CCNc1ncc(COCC2CCCCCCCCCCC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCCCCCCC1",
"old_substring": "C18CCCCC1"
}
|
Can you make molecule CCNc1ncc(COCC2CCCCC2)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCNc1ncc(COCC2(C#N)CCCCCCC2)s1
|
CCNc1ncc(COCC2CCCCC2)s1
|
CCNc1ncc(COCC2(C#N)CCCCCCC2)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCCCCCC1",
"old_substring": "C18CCCCC1"
}
|
Can you make molecule CC[C@H](C)C(=O)Nc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C(=O)Nc1ccccc1
|
CC[C@H](C)C(=O)Nc1ccccn1
|
CC[C@H](C)C(=O)Nc1ccccc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1",
"old_substring": "c13ccccn1"
}
|
Can you make molecule CC[C@H](C)C(=O)Nc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C(=O)Nc1ccc(I)cn1
|
CC[C@H](C)C(=O)Nc1ccccn1
|
CC[C@H](C)C(=O)Nc1ccc(I)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cn1",
"old_substring": "c13ccccn1"
}
|
Can you make molecule CC[C@H](C)C(=O)Nc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C(=O)Nc1cccc(Cl)n1
|
CC[C@H](C)C(=O)Nc1ccccn1
|
CC[C@H](C)C(=O)Nc1cccc(Cl)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(Cl)n1",
"old_substring": "c13ccccn1"
}
|
Can you make molecule CC[C@H](C)C(=O)Nc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C(=O)Nc1cc(Br)ccn1
|
CC[C@H](C)C(=O)Nc1ccccn1
|
CC[C@H](C)C(=O)Nc1cc(Br)ccn1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)ccn1",
"old_substring": "c13ccccn1"
}
|
Can you make molecule CC[C@H](C)C(=O)Nc1ccccn1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C)C(=O)c1cc2cn(ccs1)[nH]2
|
CC[C@H](C)C(=O)Nc1ccccn1
|
CC[C@H](C)C(=O)c1cc2cn(ccs1)[nH]2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2sccn2c1",
"old_substring": "c13ccccn1"
}
|
Can you make molecule Fc1ccc(C[NH2+]C[C@@H]([C@H]2CCOC2)N2CCOCC2)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc(C[NH2+]C2C[C@@H]([C@H]3CCOC3)C[C@@H](N3CCOCC3)C2)c(F)c1
|
Fc1ccc(C[NH2+]C[C@@H]([C@H]2CCOC2)N2CCOCC2)c(F)c1
|
Fc1ccc(C[NH2+]C2C[C@@H]([C@H]3CCOC3)C[C@@H](N3CCOCC3)C2)c(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&C[C@H]&C[C@H]&C1",
"old_substring": "C4[C@H]56"
}
|
Can you make molecule Fc1ccc(C[NH2+]C[C@@H]([C@H]2CCOC2)N2CCOCC2)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1[nH]c(N2CCOCC2)c([C@H]2CCOC2)c1[NH2+]Cc1ccc(F)cc1F
|
Fc1ccc(C[NH2+]C[C@@H]([C@H]2CCOC2)N2CCOCC2)c(F)c1
|
Cc1[nH]c(N2CCOCC2)c([C@H]2CCOC2)c1[NH2+]Cc1ccc(F)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(C)[nH]c&c1&",
"old_substring": "C4[C@H]56"
}
|
Can you make molecule Fc1ccc(C[NH2+]C[C@@H]([C@H]2CCOC2)N2CCOCC2)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(N2CCOCC2)[nH]c([NH2+]Cc2ccc(F)cc2F)c1[C@H]1CCOC1
|
Fc1ccc(C[NH2+]C[C@@H]([C@H]2CCOC2)N2CCOCC2)c(F)c1
|
Cc1c(N2CCOCC2)[nH]c([NH2+]Cc2ccc(F)cc2F)c1[C@H]1CCOC1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&[nH]c&c(C)c1&",
"old_substring": "C4[C@H]56"
}
|
Can you make molecule Fc1ccc(C[NH2+]C[C@@H]([C@H]2CCOC2)N2CCOCC2)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc(C[NH2+][C@H]2CC[C@@]([C@H]3CCOC3)(N3CCOCC3)C2)c(F)c1
|
Fc1ccc(C[NH2+]C[C@@H]([C@H]2CCOC2)N2CCOCC2)c(F)c1
|
Fc1ccc(C[NH2+][C@H]2CC[C@@]([C@H]3CCOC3)(N3CCOCC3)C2)c(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@]&&C1",
"old_substring": "C4[C@H]56"
}
|
Can you make molecule Fc1ccc(C[NH2+]C[C@@H]([C@H]2CCOC2)N2CCOCC2)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
Fc1ccc(C[NH2+][C@H]2CC[C@]([C@H]3CCOC3)(N3CCOCC3)C2)c(F)c1
|
Fc1ccc(C[NH2+]C[C@@H]([C@H]2CCOC2)N2CCOCC2)c(F)c1
|
Fc1ccc(C[NH2+][C@H]2CC[C@]([C@H]3CCOC3)(N3CCOCC3)C2)c(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC[C@@]&&C1",
"old_substring": "C4[C@H]56"
}
|
Can you make molecule CCc1cc(Cn2cc(N)nn2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CSc1cc(Cn2cc(N)nn2)n(C)n1
|
CCc1cc(Cn2cc(N)nn2)n(C)n1
|
C=CSc1cc(Cn2cc(N)nn2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CS&",
"old_substring": "CC4"
}
|
Can you make molecule CCc1cc(Cn2cc(N)nn2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)c1cc(Cn2cc(N)nn2)n(C)n1
|
CCc1cc(Cn2cc(N)nn2)n(C)n1
|
CC(C)c1cc(Cn2cc(N)nn2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(C)C",
"old_substring": "CC4"
}
|
Can you make molecule CCc1cc(Cn2cc(N)nn2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCc1cc(Cn2cc(N)nn2)n(C)n1
|
CCc1cc(Cn2cc(N)nn2)n(C)n1
|
C=CCCc1cc(Cn2cc(N)nn2)n(C)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCC&",
"old_substring": "CC4"
}
|
Can you make molecule CCc1cc(Cn2cc(N)nn2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1nc(CCCCl)cc1Cn1cc(N)nn1
|
CCc1cc(Cn2cc(N)nn2)n(C)n1
|
Cn1nc(CCCCl)cc1Cn1cc(N)nn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCl",
"old_substring": "CC4"
}
|
Can you make molecule CCc1cc(Cn2cc(N)nn2)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cn1nc(CCCCS)cc1Cn1cc(N)nn1
|
CCc1cc(Cn2cc(N)nn2)n(C)n1
|
Cn1nc(CCCCS)cc1Cn1cc(N)nn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCS",
"old_substring": "CC4"
}
|
Can you make molecule N#Cc1cccnc1Oc1ccccc1NCc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cccnc1OC(=S)Sc1ccccc1NCc1cccc2ccccc12
|
N#Cc1cccnc1Oc1ccccc1NCc1cccc2ccccc12
|
N#Cc1cccnc1OC(=S)Sc1ccccc1NCc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "O34"
}
|
Can you make molecule N#Cc1cccnc1Oc1ccccc1NCc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cccnc1C(=O)CCC(=O)c1ccccc1NCc1cccc2ccccc12
|
N#Cc1cccnc1Oc1ccccc1NCc1cccc2ccccc12
|
N#Cc1cccnc1C(=O)CCC(=O)c1ccccc1NCc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&CCC&=O",
"old_substring": "O34"
}
|
Can you make molecule N#Cc1cccnc1Oc1ccccc1NCc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cccnc1[C@H](O)CCc1ccccc1NCc1cccc2ccccc12
|
N#Cc1cccnc1Oc1ccccc1NCc1cccc2ccccc12
|
N#Cc1cccnc1[C@H](O)CCc1ccccc1NCc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@@H]&CC&",
"old_substring": "O34"
}
|
Can you make molecule N#Cc1cccnc1Oc1ccccc1NCc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cccnc1C(=O)/C=C/Sc1ccccc1NCc1cccc2ccccc12
|
N#Cc1cccnc1Oc1ccccc1NCc1cccc2ccccc12
|
N#Cc1cccnc1C(=O)/C=C/Sc1ccccc1NCc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O34"
}
|
Can you make molecule N#Cc1cccnc1Oc1ccccc1NCc1cccc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
N#Cc1cccnc1[C@H](O)CCCc1ccccc1NCc1cccc2ccccc12
|
N#Cc1cccnc1Oc1ccccc1NCc1cccc2ccccc12
|
N#Cc1cccnc1[C@H](O)CCCc1ccccc1NCc1cccc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@@H]&CCC&",
"old_substring": "O34"
}
|
Can you make molecule O=C(NCc1ccc([N+](=O)[O-])cc1)N[C@@H]1CCCC[C@H]1CO less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCc1ccc([N+](=O)[O-])cc1)NC1CCC(=CO)CC1
|
O=C(NCc1ccc([N+](=O)[O-])cc1)N[C@@H]1CCCC[C@H]1CO
|
O=C(NCc1ccc([N+](=O)[O-])cc1)NC1CCC(=CO)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC=&CC1",
"old_substring": "[C@@H]15CCCC[C@H]16"
}
|
Can you make molecule O=C(NCc1ccc([N+](=O)[O-])cc1)N[C@@H]1CCCC[C@H]1CO less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)[C@H](CCCO)NC(=O)NCc1ccc([N+](=O)[O-])cc1
|
O=C(NCc1ccc([N+](=O)[O-])cc1)N[C@@H]1CCCC[C@H]1CO
|
CC(C)(C)[C@H](CCCO)NC(=O)NCc1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(CC&)C(C)(C)C",
"old_substring": "[C@@H]15CCCC[C@H]16"
}
|
Can you make molecule O=C(NCc1ccc([N+](=O)[O-])cc1)N[C@@H]1CCCC[C@H]1CO less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CC(C)(C)CCO)NC(=O)NCc1ccc([N+](=O)[O-])cc1
|
O=C(NCc1ccc([N+](=O)[O-])cc1)N[C@@H]1CCCC[C@H]1CO
|
C[C@@H](CC(C)(C)CCO)NC(=O)NCc1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]&(C)CC(C)(C)C&",
"old_substring": "[C@@H]15CCCC[C@H]16"
}
|
Can you make molecule O=C(NCc1ccc([N+](=O)[O-])cc1)N[C@@H]1CCCC[C@H]1CO less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC[C@@H](CCCO)NC(=O)NCc1ccc([N+](=O)[O-])cc1
|
O=C(NCc1ccc([N+](=O)[O-])cc1)N[C@@H]1CCCC[C@H]1CO
|
CCCC[C@@H](CCCO)NC(=O)NCc1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC[C@H]&CC&",
"old_substring": "[C@@H]15CCCC[C@H]16"
}
|
Can you make molecule O=C(NCc1ccc([N+](=O)[O-])cc1)N[C@@H]1CCCC[C@H]1CO less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CCO)CCC=NC(=O)NCc1ccc([N+](=O)[O-])cc1
|
O=C(NCc1ccc([N+](=O)[O-])cc1)N[C@@H]1CCCC[C@H]1CO
|
C[C@@H](CCO)CCC=NC(=O)NCc1ccc([N+](=O)[O-])cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=&CC[C@@H](C)C&",
"old_substring": "[C@@H]15CCCC[C@H]16"
}
|
Can you make molecule C[C@@H](CNC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CNC(C)(C)CC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O
|
C[C@@H](CNC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O
|
C[C@@H](CNC(C)(C)CC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule C[C@@H](CNC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CNC(C)(C)CCC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O
|
C[C@@H](CNC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O
|
C[C@@H](CNC(C)(C)CCC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C23=O"
}
|
Can you make molecule C[C@@H](CNC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(N[C@@H](C)c2ccc(S(C)(=O)=O)cc2)c(=O)n(NC[C@H](C)C[C@@H](C)O)n1C
|
C[C@@H](CNC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O
|
Cc1c(N[C@@H](C)c2ccc(S(C)(=O)=O)cc2)c(=O)n(NC[C@H](C)C[C@@H](C)O)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1c&c(=O)n&n1C",
"old_substring": "C23=O"
}
|
Can you make molecule C[C@@H](CNC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cc(=O)c(N[C@@H](C)c2ccc(S(C)(=O)=O)cc2)nn1NC[C@H](C)C[C@@H](C)O
|
C[C@@H](CNC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O
|
Cc1cc(=O)c(N[C@@H](C)c2ccc(S(C)(=O)=O)cc2)nn1NC[C@H](C)C[C@@H](C)O
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(=O)c&nn1&",
"old_substring": "C23=O"
}
|
Can you make molecule C[C@@H](CNC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CN[C@H](Br)CC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O
|
C[C@@H](CNC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O
|
C[C@@H](CN[C@H](Br)CC(=O)N[C@@H](C)c1ccc(S(C)(=O)=O)cc1)C[C@@H](C)O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@H]&Br",
"old_substring": "C23=O"
}
|
Can you make molecule CC(C)Oc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CCOc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1
|
CC(C)Oc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1
|
CC(C)CCOc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC&",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)Oc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CNC(=O)Nc1ccc(OCCCCBr)cc1F)N1CCOCC1
|
CC(C)Oc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1
|
C[C@@H](CNC(=O)Nc1ccc(OCCCCBr)cc1F)N1CCOCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCBr",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)Oc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCOc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1
|
CC(C)Oc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1
|
C=CCCCOc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCC&",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)Oc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CNC(=O)Nc1ccc(OCCCCCl)cc1F)N1CCOCC1
|
CC(C)Oc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1
|
C[C@@H](CNC(=O)Nc1ccc(OCCCCCl)cc1F)N1CCOCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCCl",
"old_substring": "CC5C"
}
|
Can you make molecule CC(C)Oc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C=CCCCCOc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1
|
CC(C)Oc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1
|
C=CCCCCOc1ccc(NC(=O)NC[C@H](C)N2CCOCC2)c(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C=CCCCC&",
"old_substring": "CC5C"
}
|
Can you make molecule COc1ccccc1COC1CCN(C(=O)[C@H]2CCC[C@@H](C)C2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1COC1CCC(C(=O)[C@H]2CCC[C@@H](C)C2)CC1
|
COc1ccccc1COC1CCN(C(=O)[C@H]2CCC[C@@H](C)C2)CC1
|
COc1ccccc1COC1CCC(C(=O)[C@H]2CCC[C@@H](C)C2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&CC1",
"old_substring": "C15CCN3CC1"
}
|
Can you make molecule COc1ccccc1COC1CCN(C(=O)[C@H]2CCC[C@@H](C)C2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1COC1CCC(C)(C(=O)[C@H]2CCC[C@@H](C)C2)CC1
|
COc1ccccc1COC1CCN(C(=O)[C@H]2CCC[C@@H](C)C2)CC1
|
COc1ccccc1COC1CCC(C)(C(=O)[C@H]2CCC[C@@H](C)C2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCC&(C)CC1",
"old_substring": "C15CCN3CC1"
}
|
Can you make molecule COc1ccccc1COC1CCN(C(=O)[C@H]2CCC[C@@H](C)C2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1COC1(C#N)CCC(C(=O)[C@H]2CCC[C@@H](C)C2)CC1
|
COc1ccccc1COC1CCN(C(=O)[C@H]2CCC[C@@H](C)C2)CC1
|
COc1ccccc1COC1(C#N)CCC(C(=O)[C@H]2CCC[C@@H](C)C2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C#N)CCC&CC1",
"old_substring": "C15CCN3CC1"
}
|
Can you make molecule COc1ccccc1COC1CCN(C(=O)[C@H]2CCC[C@@H](C)C2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1COCCCCCC(=O)[C@H]1CCC[C@@H](C)C1
|
COc1ccccc1COC1CCN(C(=O)[C@H]2CCC[C@@H](C)C2)CC1
|
COc1ccccc1COCCCCCC(=O)[C@H]1CCC[C@@H](C)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC&",
"old_substring": "C15CCN3CC1"
}
|
Can you make molecule COc1ccccc1COC1CCN(C(=O)[C@H]2CCC[C@@H](C)C2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccccc1CON1CCC=C(CC(=O)[C@H]2CCC[C@@H](C)C2)C1
|
COc1ccccc1COC1CCN(C(=O)[C@H]2CCC[C@@H](C)C2)CC1
|
COc1ccccc1CON1CCC=C(CC(=O)[C@H]2CCC[C@@H](C)C2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCC=C(C&)C1",
"old_substring": "C15CCN3CC1"
}
|
Can you make molecule CC(=O)O[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)OC(=S)S[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C
|
CC(=O)O[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C
|
CC(=O)OC(=S)S[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=S)S&",
"old_substring": "O68"
}
|
Can you make molecule CC(=O)O[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)OC(=N)C[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C
|
CC(=O)O[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C
|
CC(=O)OC(=N)C[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C
| 102
|
{
"fragment_index": 0,
"new_substring": "O&C(=N)C&",
"old_substring": "O68"
}
|
Can you make molecule CC(=O)O[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)O[C@H]1C[C@H]2[C@@H](CC[C@]3(C)[C@@H](S/C=C/C(=O)C(C)=O)CC[C@@H]23)[C@@]2(C)CC[C@@H]3C[C@]312
|
CC(=O)O[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C
|
CC(=O)O[C@H]1C[C@H]2[C@@H](CC[C@]3(C)[C@@H](S/C=C/C(=O)C(C)=O)CC[C@@H]23)[C@@]2(C)CC[C@@H]3C[C@]312
| 102
|
{
"fragment_index": 0,
"new_substring": "O=C&/C=C/S&",
"old_substring": "O68"
}
|
Can you make molecule CC(=O)O[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)O[C@H]1C[C@H]2[C@@H](CC[C@]3(C)[C@@H](CCC[C@@H](O)C(C)=O)CC[C@@H]23)[C@@]2(C)CC[C@@H]3C[C@]312
|
CC(=O)O[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C
|
CC(=O)O[C@H]1C[C@H]2[C@@H](CC[C@]3(C)[C@@H](CCC[C@@H](O)C(C)=O)CC[C@@H]23)[C@@]2(C)CC[C@@H]3C[C@]312
| 102
|
{
"fragment_index": 0,
"new_substring": "O[C@@H]&CCC&",
"old_substring": "O68"
}
|
Can you make molecule CC(=O)O[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)O[C@H]1C[C@H]2[C@@H](CC[C@]3(C)[C@@H](n4ncc(C(C)=O)cc4=O)CC[C@@H]23)[C@@]2(C)CC[C@@H]3C[C@]312
|
CC(=O)O[C@H]1CC[C@H]2[C@H]3C[C@H](OC(C)=O)[C@]45C[C@H]4CC[C@]5(C)[C@@H]3CC[C@]12C
|
CC(=O)O[C@H]1C[C@H]2[C@@H](CC[C@]3(C)[C@@H](n4ncc(C(C)=O)cc4=O)CC[C@@H]23)[C@@]2(C)CC[C@@H]3C[C@]312
| 102
|
{
"fragment_index": 0,
"new_substring": "O=c1cc&cnn1&",
"old_substring": "O68"
}
|
Can you make molecule CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)C)C2=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C1(C)CCCC1)C2=O
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)C)C2=O
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C1(C)CCCC1)C2=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CCCC1",
"old_substring": "C5(C)C"
}
|
Can you make molecule CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)C)C2=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(Cl)(Cl)Cl)C2=O
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)C)C2=O
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(Cl)(Cl)Cl)C2=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(Cl)(Cl)Cl",
"old_substring": "C5(C)C"
}
|
Can you make molecule CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)C)C2=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)(C)CCC)C2=O
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)C)C2=O
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)(C)CCC)C2=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&(C)C",
"old_substring": "C5(C)C"
}
|
Can you make molecule CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)C)C2=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)(CC)CC)C2=O
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)C)C2=O
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)(CC)CC)C2=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(C)CC",
"old_substring": "C5(C)C"
}
|
Can you make molecule CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)C)C2=O less soluble in water? The output molecule should be similar to the input molecule.
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C1(C=O)CCCCCC1)C2=O
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C(C)C)C2=O
|
CCCn1nnnc1CN1CC[C@]2(C1)NC(=O)N(C1(C=O)CCCCCC1)C2=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C=O)CCCCCC1",
"old_substring": "C5(C)C"
}
|
Can you make molecule CC1=C(C(=O)OCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OC(C)(C)CCBr)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
|
CC1=C(C(=O)OCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
|
CC1=C(C(=O)OC(C)(C)CCBr)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC&(C)CCBr",
"old_substring": "C4C(C)C"
}
|
Can you make molecule CC1=C(C(=O)OCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(C)(C)OC(=O)C1=C(C)Nc2c(c(=O)n(C)c(=O)n2C)[C@H]1c1cccc(F)c1
|
CC1=C(C(=O)OCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
|
CCCC(C)(C)OC(=O)C1=C(C)Nc2c(c(=O)n(C)c(=O)n2C)[C@H]1c1cccc(F)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&(C)C",
"old_substring": "C4C(C)C"
}
|
Can you make molecule CC1=C(C(=O)OCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OCC(C)(C)CBr)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
|
CC1=C(C(=O)OCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
|
CC1=C(C(=O)OCC(C)(C)CBr)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(C)(C)CBr",
"old_substring": "C4C(C)C"
}
|
Can you make molecule CC1=C(C(=O)OCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OC(C(C)C)C(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
|
CC1=C(C(=O)OCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
|
CC1=C(C(=O)OC(C(C)C)C(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)C&C(C)C",
"old_substring": "C4C(C)C"
}
|
Can you make molecule CC1=C(C(=O)OCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OC(=O)CCCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
|
CC1=C(C(=O)OCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
|
CC1=C(C(=O)OC(=O)CCCC(C)C)[C@H](c2cccc(F)c2)c2c(n(C)c(=O)n(C)c2=O)N1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CCCC&=O",
"old_substring": "C4C(C)C"
}
|
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