prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of ETFB in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | ETFB | cell proliferation | Gastric Cancer Cell Line | Gene: ETFB (electron transfer flavoprotein subunit beta)
Type: protein-coding
Summary: This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-... |
Does Knockout of OSGIN1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | OSGIN1 | cell proliferation | Ovarian Cancer Cell Line | Gene: OSGIN1 (oxidative stress induced growth inhibitor 1)
Type: protein-coding
Summary: This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c rel... |
Does Knockout of NHP2 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | NHP2 | cell proliferation | Colonic Cancer Cell Line | Gene: NHP2 (NHP2 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA ... |
Does Knockout of SPRR2G in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | SPRR2G | cell proliferation | Melanoma Cell Line | Gene: SPRR2G (small proline rich protein 2G)
Type: protein-coding
Summary: Predicted to be involved in keratinization. Predicted to be located in cornified envelope and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epidermis development, keratinization, kerati... |
Does Knockout of IQCE in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | IQCE | cell proliferation | Monocytic Leukemia Cell Line | Gene: IQCE (IQ motif containing E)
Type: protein-coding
Summary: Involved in limb morphogenesis. Predicted to be extrinsic component of membrane. Predicted to be part of plasma membrane protein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell projection, cil... |
Does Knockout of DNAJA1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | DNAJA1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1)
Type: protein-coding
Summary: This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolyti... |
Does Knockout of AVL9 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | AVL9 | response to virus | Hepatoma Cell Line | Gene: AVL9 (AVL9 cell migration associated)
Type: protein-coding
Summary: Involved in cell migration. Located in recycling endosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, endosome, membrane, recycling endosome
Pathways:
UniProt: Q8... |
Does Knockout of CCAR1 in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | CCAR1 | response to virus | Hepatoma Cell Line | Gene: CCAR1 (cell division cycle and apoptosis regulator 1)
Type: protein-coding
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor coactivator activity; and transcription corepressor activity. Involved in positive regulation of cell migrati... |
Does Knockout of IMP4 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | IMP4 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: IMP4 (IMP U3 small nucleolar ribonucleoprotein 4)
Type: protein-coding
Summary: The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal R... |
Does Knockout of CPEB3 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | CPEB3 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: CPEB3 (cytoplasmic polyadenylation element binding protein 3)
Type: protein-coding
Summary: Enables mRNA 3'-UTR binding activity and translation factor activity, RNA binding. Involved in cellular response to amino acid stimulus; negative regulation of transcription by RNA polymerase II; and positi... |
Does Knockout of YRDC in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 2,459 | Knockout | YRDC | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: YRDC (yrdC N6-threonylcarbamoyltransferase domain containing)
Type: protein-coding
Summary: Predicted to enable nucleotidyltransferase activity and tRNA binding activity. Acts upstream of or within negative regulation of transport. Predicted to be located in membrane and mitochondrion. Predicted t... |
Does Knockout of COX6B1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | COX6B1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: COX6B1 (cytochrome c oxidase subunit 6B1)
Type: protein-coding
Summary: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encode... |
Does Activation of SLIT3 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | SLIT3 | response to virus | Hepatoma Cell Line | Gene: SLIT3 (slit guidance ligand 3)
Type: protein-coding
Summary: The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012... |
Does Knockout of PARN in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | PARN | response to chemicals | Colorectal Cancer Cell Line | Gene: PARN (poly(A)-specific ribonuclease)
Type: protein-coding
Summary: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation... |
Does Knockout of PIK3C3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | PIK3C3 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3)
Type: protein-coding
Summary: Enables 1-phosphatidylinositol-3-kinase activity. Involved in early endosome to late endosome transport and regulation of cytokinesis. Acts upstream of or within autophagy and protein lipidation. Located ... |
Does Knockout of HRH4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | HRH4 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: HRH4 (histamine receptor H4)
Type: protein-coding
Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor supe... |
Does Activation of OS9 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | OS9 | protein/peptide accumulation | T cell | Gene: OS9 (OS9 endoplasmic reticulum lectin)
Type: protein-coding
Summary: This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of... |
Does Knockout of SLC35G3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | SLC35G3 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: SLC35G3 (solute carrier family 35 member G3)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane
Pathways:
UniProt: Q8N808
Entrez ID: 146861 |
Does Knockout of HSCB in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | HSCB | cell proliferation | Bladder Carcinoma | Gene: HSCB (HscB mitochondrial iron-sulfur cluster cochaperone)
Type: protein-coding
Summary: This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are... |
Does Knockout of AP4E1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | AP4E1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: AP4E1 (adaptor related protein complex 4 subunit epsilon 1)
Type: protein-coding
Summary: This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory a... |
Does Knockout of HS6ST2 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | HS6ST2 | cell proliferation | Ovarian Cancer Cell Line | Gene: HS6ST2 (heparan sulfate 6-O-sulfotransferase 2)
Type: protein-coding
Summary: Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migrat... |
Does Knockout of LILRB5 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | LILRB5 | cell proliferation | Colonic Cancer Cell Line | Gene: LILRB5 (leukocyte immunoglobulin like receptor B5)
Type: protein-coding
Summary: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors w... |
Does Knockout of PRMT1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | PRMT1 | cell proliferation | Medulloblastoma Cell Line | Gene: PRMT1 (protein arginine methyltransferase 1)
Type: protein-coding
Summary: This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMT... |
Does Knockout of ALG11 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | ALG11 | cell proliferation | Bladder Carcinoma | Gene: ALG11 (ALG11 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue f... |
Does Knockout of UBE2M in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | UBE2M | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: UBE2M (ubiquitin conjugating enzyme E2 M)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enz... |
Does Knockout of SUPT4H1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | SUPT4H1 | cell proliferation | Colonic Cancer Cell Line | Gene: SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit)
Type: protein-coding
Summary: This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymer... |
Does Knockout of SELP in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | SELP | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: SELP (selectin P)
Type: protein-coding
Summary: This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the inter... |
Does Knockout of OR9G4 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | OR9G4 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: OR9G4 (olfactory receptor family 9 subfamily G member 4)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of POLD3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | POLD3 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: POLD3 (DNA polymerase delta 3, accessory subunit)
Type: protein-coding
Summary: This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protei... |
Does Knockout of OR2J3 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | OR2J3 | response to virus | Lung Cancer Cell Line | Gene: OR2J3 (olfactory receptor family 2 subfamily J member 3)
Type: protein-coding
Summary: This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the pe... |
Does Knockout of MYBL2 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | MYBL2 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: MYBL2 (MYB proto-oncogene like 2)
Type: protein-coding
Summary: The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during th... |
Does Knockout of EIF2B1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | EIF2B1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha)
Type: protein-coding
Summary: This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis.... |
Does Knockout of TFIP11 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | TFIP11 | cell proliferation | Endometrial Cancer Cell Line | Gene: TFIP11 (tuftelin interacting protein 11)
Type: protein-coding
Summary: This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded p... |
Does Knockout of SRP68 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | SRP68 | cell proliferation | Endometrial Cancer Cell Line | Gene: SRP68 (signal recognition particle 68)
Type: protein-coding
Summary: This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RN... |
Does Knockout of PSENEN in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | PSENEN | cell proliferation | T-lymphoma cell line | Gene: PSENEN (presenilin enhancer, gamma-secretase subunit)
Type: protein-coding
Summary: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor... |
Does Knockout of KATNB1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | KATNB1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: KATNB1 (katanin regulatory subunit B1)
Type: protein-coding
Summary: Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 s... |
Does Knockout of FOLH1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | FOLH1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: FOLH1 (folate hydrolase 1)
Type: protein-coding
Summary: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l... |
Does Knockout of ZSCAN9 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | ZSCAN9 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ZSCAN9 (zinc finger and SCAN domain containing 9)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resource... |
Does Knockout of SF3B3 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | SF3B3 | cell proliferation | Glioblastoma Cell Line | Gene: SF3B3 (splicing factor 3b subunit 3)
Type: protein-coding
Summary: This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3... |
Does Knockout of SEMG1 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | SEMG1 | cell proliferation | Gastric Cancer Cell Line | Gene: SEMG1 (semenogelin 1)
Type: protein-coding
Summary: The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-s... |
Does Knockout of SMAD2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | SMAD2 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: SMAD2 (SMAD family member 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and tr... |
Does Knockout of SNRPC in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | SNRPC | cell proliferation | Mammary Gland Tumor Cell Line | Gene: SNRPC (small nuclear ribonucleoprotein polypeptide C)
Type: protein-coding
Summary: This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing ... |
Does Knockout of MRPS5 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | MRPS5 | cell proliferation | Melanoma Cell Line | Gene: MRPS5 (mitochondrial ribosomal protein S5)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. T... |
Does Knockout of CHKB in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | CHKB | cell proliferation | Multiple Myeloma Cell Line | Gene: CHKB (choline kinase beta)
Type: protein-coding
Summary: Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all ... |
Does Knockout of VSTM4 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | VSTM4 | response to virus | Lung Cancer Cell Line | Gene: VSTM4 (V-set and transmembrane domain containing 4)
Type: protein-coding
Summary: Predicted to act upstream of or within several processes, including endothelial cell migration; retina blood vessel maintenance; and vasculature development. Predicted to be located in extracellular region and plasma... |
Does Knockout of SLC5A1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | SLC5A1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: SLC5A1 (solute carrier family 5 member 1)
Type: protein-coding
Summary: This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations i... |
Does Knockout of MRPL43 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | MRPL43 | cell proliferation | Renal Cancer Cell Line | Gene: MRPL43 (mitochondrial ribosomal protein L43)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of ZNF607 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | ZNF607 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: ZNF607 (zinc finger protein 607)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of CHM in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | CHM | cell proliferation | Prostate Cancer Cell Line | Gene: CHM (CHM Rab escort protein)
Type: protein-coding
Summary: This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transf... |
Does Knockout of DPPA2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | DPPA2 | cell proliferation | Colonic Cancer Cell Line | Gene: DPPA2 (developmental pluripotency associated 2)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity. Predicted to be involved in system development. Predicted to act upstream of or within several processes, including lung-associated mesenchyme development; positive regulat... |
Does Knockout of TSC22D2 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | TSC22D2 | cell proliferation | Endometrial Cancer Cell Line | Gene: TSC22D2 (TSC22 domain family member 2)
Type: protein-coding
Summary: Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within response to osmotic stress. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: neg... |
Does Knockout of ATOH1 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | ATOH1 | response to virus | Hepatoma Cell Line | Gene: ATOH1 (atonal bHLH transcription factor 1)
Type: protein-coding
Summary: This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]
Gene Ontology: BP: Notch signaling ... |
Does Knockout of PCK1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | PCK1 | cell proliferation | Medulloblastoma Cell Line | Gene: PCK1 (phosphoenolpyruvate carboxykinase 1)
Type: protein-coding
Summary: This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon ... |
Does Knockout of TNS1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | TNS1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: TNS1 (tensin 1)
Type: protein-coding
Summary: The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found ... |
Does Knockout of LCNL1 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | LCNL1 | cell proliferation | Glioblastoma Cell Line | Gene: LCNL1 (lipocalin like 1)
Type: protein-coding
Summary: Predicted to enable small molecule binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q6ZST4
Entrez ID: 401562 |
Does Knockout of PUF60 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | PUF60 | cell proliferation | Cancer Cell Line | Gene: PUF60 (poly(U) binding splicing factor 60)
Type: protein-coding
Summary: This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA e... |
Does Knockout of TTK in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | TTK | cell proliferation | Ovarian Cancer Cell Line | Gene: TTK (TTK protein kinase)
Type: protein-coding
Summary: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and i... |
Does Knockout of PDCD5 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | PDCD5 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: PDCD5 (programmed cell death 5)
Type: protein-coding
Summary: This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in ... |
Does Knockout of MDH2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | MDH2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: MDH2 (malate dehydrogenase 2)
Type: protein-coding
Summary: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal rol... |
Does Knockout of KBTBD4 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | KBTBD4 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: KBTBD4 (kelch repeat and BTB domain containing 4)
Type: protein-coding
Summary: kelch repeat and BTB domain containing 4
Gene Ontology:
Pathways:
UniProt: Q9NVX7
Entrez ID: 55709 |
Does Knockout of ARFIP2 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | ARFIP2 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: ARFIP2 (ARF interacting protein 2)
Type: protein-coding
Summary: Enables several functions, including GTP-dependent protein binding activity; membrane curvature sensor activity; and phosphatidylinositol-4-phosphate binding activity. Involved in actin cytoskeleton organization. Located in cell cort... |
Does Knockout of WDR83 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | WDR83 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: WDR83 (WD repeat domain 83)
Type: protein-coding
Summary: This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulat... |
Does Knockout of NPAS2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | NPAS2 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: NPAS2 (neuronal PAS domain protein 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may ... |
Does Knockout of FOXRED2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | FOXRED2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: FOXRED2 (FAD dependent oxidoreductase domain containing 2)
Type: protein-coding
Summary: Enables flavin adenine dinucleotide binding activity. Involved in ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene On... |
Does Knockout of SGCD in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | SGCD | cell proliferation | Colonic Cancer Cell Line | Gene: SGCD (sarcoglycan delta)
Type: protein-coding
Summary: The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix... |
Does Knockout of DEGS2 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | DEGS2 | cell proliferation | Renal Cancer Cell Line | Gene: DEGS2 (delta 4-desaturase, sphingolipid 2)
Type: protein-coding
Summary: This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, an... |
Does Knockout of CASQ1 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | CASQ1 | cell proliferation | Gastric Cancer Cell Line | Gene: CASQ1 (calsequestrin 1)
Type: protein-coding
Summary: This gene encodes the skeletal muscle specific member of the calsequestrin protein family. Calsequestrin functions as a luminal sarcoplasmic reticulum calcium sensor in both cardiac and skeletal muscle cells. This protein, also known as calmiti... |
Does Knockout of SLFN12 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | SLFN12 | cell proliferation | Colorectal Cancer Cell Line | Gene: SLFN12 (schlafen family member 12)
Type: protein-coding
Summary: Predicted to act upstream of or within negative regulation of cell population proliferation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic signaling pathway, rRNA catabolic process; MF: RN... |
Does Knockout of KANSL2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | KANSL2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: KANSL2 (KAT8 regulatory NSL complex subunit 2)
Type: protein-coding
Summary: Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Part of histone acetyltrans... |
Does Knockout of ARHGDIG in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | ARHGDIG | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: ARHGDIG (Rho GDP dissociation inhibitor gamma)
Type: protein-coding
Summary: The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010].
Gene Ontology: ... |
Does Knockout of PRAMEF10 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | PRAMEF10 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: PRAMEF10 (PRAME family member 10)
Type: protein-coding
Summary: Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active i... |
Does Knockout of ORC3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | ORC3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ORC3 (origin recognition complex subunit 3)
Type: protein-coding
Summary: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to or... |
Does Knockout of EIF3A in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | EIF3A | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: EIF3A (eukaryotic translation initiation factor 3 subunit A)
Type: protein-coding
Summary: Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and vi... |
Does Knockout of MAT2A in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | MAT2A | cell proliferation | Colorectal Cancer Cell Line | Gene: MAT2A (methionine adenosyltransferase 2A)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011].
Gene Ontology: ... |
Does Knockout of MED20 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | MED20 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: MED20 (mediator complex subunit 20)
Type: protein-coding
Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited b... |
Does Knockout of FIP1L1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | FIP1L1 | cell proliferation | Medulloblastoma Cell Line | Gene: FIP1L1 (factor interacting with PAPOLA and CPSF1)
Type: protein-coding
Summary: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), b... |
Does Knockout of GABRA1 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | GABRA1 | response to chemicals | Colorectal Cancer Cell Line | Gene: GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1)
Type: protein-coding
Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channel... |
Does Knockout of ZNF292 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | ZNF292 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: ZNF292 (zinc finger protein 292)
Type: protein-coding
Summary: This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocy... |
Does Knockout of UNC13A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | UNC13A | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: UNC13A (unc-13 homolog A)
Type: protein-coding
Summary: This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with spo... |
Does Knockout of U2AF1 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | U2AF1 | response to chemicals | Monocytic Leukemia Cell Line | Gene: U2AF1 (U2 small nuclear RNA auxiliary factor 1)
Type: protein-coding
Summary: This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene... |
Does Knockout of VPS54 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | VPS54 | cell proliferation | Medulloblastoma Cell Line | Gene: VPS54 (VPS54 subunit of GARP complex)
Type: protein-coding
Summary: This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian V... |
Does Knockout of PRAC1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | PRAC1 | cell proliferation | Endometrial Cancer Cell Line | Gene: PRAC1 (PRAC1 small nuclear protein)
Type: protein-coding
Summary: This gene is reported to be specifically expressed in prostate, rectum and distal colon. Sequence analysis suggests that it may play a regulatory role in the nucleus. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: cytos... |
Does Knockout of PRR7 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | PRR7 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: PRR7 (proline rich 7, synaptic)
Type: protein-coding
Summary: Enables long-chain fatty acid binding activity; protein tyrosine kinase binding activity; and ubiquitin-like protein ligase binding activity. Involved in negative regulation of protein ubiquitination; positive regulation of apoptotic pr... |
Does Knockout of RASA4 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | RASA4 | response to chemicals | Monocytic Leukemia Cell Line | Gene: RASA4 (RAS p21 protein activator 4)
Type: protein-coding
Summary: This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the tran... |
Does Knockout of METTL15 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | METTL15 | cell proliferation | Astrocytoma Cell Line | Gene: METTL15 (methyltransferase 15, mitochondrial 12S rRNA N4-cytidine)
Type: protein-coding
Summary: Predicted to enable rRNA (cytosine-N4-)-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to be located in mitochondrial matrix. Predicted to be integral componen... |
Does Knockout of SLC12A9 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | SLC12A9 | cell proliferation | Glioblastoma Cell Line | Gene: SLC12A9 (solute carrier family 12 member 9)
Type: protein-coding
Summary: Predicted to enable potassium:chloride symporter activity. Predicted to be involved in cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Located in extracellular exosome. [provide... |
Does Knockout of SETD7 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | SETD7 | cell proliferation | Glioblastoma Cell Line | Gene: SETD7 (SET domain containing 7, histone lysine methyltransferase)
Type: protein-coding
Summary: Enables histone-lysine N-methyltransferase activity and p53 binding activity. Involved in peptidyl-lysine dimethylation and peptidyl-lysine monomethylation. Acts upstream of or within cellular response ... |
Does Inhibition of TMX2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,184 | Inhibition | TMX2 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: TMX2 (thioredoxin related transmembrane protein 2)
Type: protein-coding
Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ... |
Does Knockout of HMGCS1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | HMGCS1 | cell proliferation | Colonic Cancer Cell Line | Gene: HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Type: protein-coding
Summary: Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytoplasm. Predicted to... |
Does Knockout of TIMM22 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | TIMM22 | cell proliferation | Renal Cancer Cell Line | Gene: TIMM22 (translocase of inner mitochondrial membrane 22)
Type: protein-coding
Summary: Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The pro... |
Does Knockout of GRAMD1A in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | GRAMD1A | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: GRAMD1A (GRAM domain containing 1A)
Type: protein-coding
Summary: Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol. Located in cytosol; organelle membrane contact site; and plasma membrane. Is extrinsic... |
Does Knockout of CCT6A in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | CCT6A | cell proliferation | Melanoma Cell Line | Gene: CCT6A (chaperonin containing TCP1 subunit 6A)
Type: protein-coding
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, ... |
Does Knockout of NCAPH2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | NCAPH2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: NCAPH2 (non-SMC condensin II complex subunit H2)
Type: protein-coding
Summary: This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants.[pr... |
Does Knockout of GDAP1L1 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | GDAP1L1 | cell proliferation | T-lymphoma cell line | Gene: GDAP1L1 (ganglioside induced differentiation associated protein 1 like 1)
Type: protein-coding
Summary: The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several ... |
Does Knockout of TIE1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | TIE1 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1)
Type: protein-coding
Summary: This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through... |
Does Knockout of DDO in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | DDO | cell proliferation | Colonic Cancer Cell Line | Gene: DDO (D-aspartate oxidase)
Type: protein-coding
Summary: The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in ... |
Does Knockout of ABRA in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | ABRA | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: ABRA (actin binding Rho activating protein)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Predicted to be involved in positive regulation of DNA-binding transcription factor activity; positive regulation of Rho protein signal transduction; and positive regulation of tra... |
Does Knockout of RAN in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | RAN | cell proliferation | Cancer Cell Line | Gene: RAN (RAN, member RAS oncogene family)
Type: protein-coding
Summary: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in co... |
Does Knockout of GNL3 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | GNL3 | cell proliferation | Gastric Cancer Cell Line | Gene: GNL3 (G protein nucleolar 3)
Type: protein-coding
Summary: The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three trans... |
Does Knockout of TMEM181 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | TMEM181 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: TMEM181 (transmembrane protein 181)
Type: protein-coding
Summary: The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010].
Gene Ontology: M... |
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