prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of ETFB in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
ETFB
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ETFB (electron transfer flavoprotein subunit beta)
Type: protein-coding
Summary: This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: amino acid catabolic process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, respiratory electron transport chain; MF: electron transfer activity, protein binding; CC: electron transfer flavoprotein complex, mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Metabolism of proteins, Post-translational protein modification, Protein methylation, Respiratory electron transport
UniProt: P38117
Entrez ID: 2109
|
Does Knockout of OSGIN1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
OSGIN1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: OSGIN1 (oxidative stress induced growth inhibitor 1)
Type: protein-coding
Summary: This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: cell differentiation, negative regulation of cell growth, signal transduction; MF: growth factor activity, monooxygenase activity, oxidoreductase activity, protein binding
Pathways:
UniProt: Q9UJX0
Entrez ID: 29948
|
Does Knockout of NHP2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
NHP2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: NHP2 (NHP2 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: rRNA processing, rRNA pseudouridine synthesis, ribosome biogenesis, snRNA pseudouridine synthesis, snoRNA guided rRNA pseudouridine synthesis, telomerase RNA localization to Cajal body, telomere maintenance via telomerase; MF: RNA binding, U3 snoRNA binding, box H/ACA snoRNA binding, mRNA 3'-UTR binding, protein binding, telomerase RNA binding; CC: Cajal body, box H/ACA scaRNP complex, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, chromosome, telomeric region, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Telomere Extension By Telomerase, Telomere Maintenance, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NX24
Entrez ID: 55651
|
Does Knockout of SPRR2G in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
SPRR2G
|
cell proliferation
|
Melanoma Cell Line
|
Gene: SPRR2G (small proline rich protein 2G)
Type: protein-coding
Summary: Predicted to be involved in keratinization. Predicted to be located in cornified envelope and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epidermis development, keratinization, keratinocyte differentiation; CC: cornified envelope, cytoplasm, cytosol
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q9BYE4
Entrez ID: 6706
|
Does Knockout of IQCE in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
IQCE
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: IQCE (IQ motif containing E)
Type: protein-coding
Summary: Involved in limb morphogenesis. Predicted to be extrinsic component of membrane. Predicted to be part of plasma membrane protein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell projection, ciliary membrane, cilium, membrane, plasma membrane
Pathways: Activation of SMO, Genes related to primary cilium development (based on CRISPR), Hedgehog 'on' state, Hedgehog signaling pathway - Homo sapiens (human), Signal Transduction, Signaling by Hedgehog
UniProt: Q6IPM2
Entrez ID: 23288
|
Does Knockout of DNAJA1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
DNAJA1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1)
Type: protein-coding
Summary: This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: negative regulation of JUN kinase activity, negative regulation of apoptotic process, negative regulation of establishment of protein localization to mitochondrion, negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway, negative regulation of protein ubiquitination, positive regulation of apoptotic process, protein folding, protein localization to mitochondrion, protein refolding, regulation of protein transport, response to heat, response to unfolded protein; MF: ATP binding, ATPase activator activity, C3HC4-type RING finger domain binding, G protein-coupled receptor binding, Hsp70 protein binding, Tat protein binding, heat shock protein binding, low-density lipoprotein particle receptor binding, metal ion binding, protein binding, protein-folding chaperone binding, ubiquitin protein ligase binding, unfolded protein binding, zinc ion binding; CC: cytoplasm, cytoplasmic side of endoplasmic reticulum membrane, cytosol, endoplasmic reticulum, extracellular exosome, membrane, microtubule cytoskeleton, mitochondrion, nucleus, perinuclear region of cytoplasm
Pathways: Cellular responses to stimuli, Cellular responses to stress, Exercise-induced Circadian Regulation, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Mitochondrial unfolded protein response (UPRmt), Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of Androgen receptor activity, VEGFA-VEGFR2 Signaling Pathway
UniProt: P31689
Entrez ID: 3301
|
Does Knockout of AVL9 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
AVL9
|
response to virus
|
Hepatoma Cell Line
|
Gene: AVL9 (AVL9 cell migration associated)
Type: protein-coding
Summary: Involved in cell migration. Located in recycling endosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, endosome, membrane, recycling endosome
Pathways:
UniProt: Q8NBF6
Entrez ID: 23080
|
Does Knockout of CCAR1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
CCAR1
|
response to virus
|
Hepatoma Cell Line
|
Gene: CCAR1 (cell division cycle and apoptosis regulator 1)
Type: protein-coding
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; nuclear receptor coactivator activity; and transcription corepressor activity. Involved in positive regulation of cell migration and positive regulation of cell population proliferation. Acts upstream of or within positive regulation of apoptotic process. Located in nuclear envelope lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of cell migration, positive regulation of cell population proliferation, protein ubiquitination, regulation of DNA-templated transcription, ubiquitin-dependent protein catabolic process; MF: RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, transcription coactivator activity, transcription corepressor activity, ubiquitin protein ligase activity; CC: cytoplasm, nuclear envelope lumen, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8IX12
Entrez ID: 55749
|
Does Knockout of IMP4 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
IMP4
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: IMP4 (IMP U3 small nucleolar ribonucleoprotein 4)
Type: protein-coding
Summary: The protein encoded by this gene, along with IMP3 and MPP10, is part of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex. This complex is necessary for the early cleavage steps of pre-18S ribosomal RNA processing. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: maturation of SSU-rRNA, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: protein binding, rRNA binding, rRNA primary transcript binding, snoRNA binding; CC: Mpp10 complex, fibrillar center, nucleolus, nucleoplasm, nucleus, preribosome, ribonucleoprotein complex, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q96G21
Entrez ID: 92856
|
Does Knockout of CPEB3 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
CPEB3
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: CPEB3 (cytoplasmic polyadenylation element binding protein 3)
Type: protein-coding
Summary: Enables mRNA 3'-UTR binding activity and translation factor activity, RNA binding. Involved in cellular response to amino acid stimulus; negative regulation of transcription by RNA polymerase II; and positive regulation of mRNA catabolic process. Located in several cellular components, including cytosol; midbody; and nucleoplasm. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, cellular response to amino acid stimulus, long-term memory, negative regulation of cytoplasmic translation, negative regulation of cytoplasmic translational elongation, negative regulation of transcription by RNA polymerase II, negative regulation of translation, positive regulation of dendritic spine development, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of translation, regulation of dendritic spine development, regulation of postsynapse assembly, regulation of synaptic plasticity, regulation of translation, translation; MF: RNA binding, RNA stem-loop binding, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, mRNA regulatory element binding translation repressor activity, nucleic acid binding, protein binding, ribosome binding, translation factor activity, RNA binding, translation regulator activity; CC: CCR4-NOT complex, apical dendrite, cell projection, cytoplasm, cytosol, dendrite, midbody, neuron projection, nucleoplasm, nucleus, plasma membrane, postsynapse, postsynaptic density, synapse
Pathways: Oocyte meiosis - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human)
UniProt: Q8NE35
Entrez ID: 22849
|
Does Knockout of YRDC in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,459
|
Knockout
|
YRDC
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: YRDC (yrdC N6-threonylcarbamoyltransferase domain containing)
Type: protein-coding
Summary: Predicted to enable nucleotidyltransferase activity and tRNA binding activity. Acts upstream of or within negative regulation of transport. Predicted to be located in membrane and mitochondrion. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transport, regulation of translational fidelity, tRNA threonylcarbamoyladenosine modification; MF: L-threonylcarbamoyladenylate synthase, double-stranded RNA binding, nucleotidyltransferase activity, protein binding, tRNA binding, transferase activity; CC: cytoplasm, membrane, mitochondrion, plasma membrane
Pathways: Metabolism of RNA, tRNA modification in the mitochondrion, tRNA processing
UniProt: Q86U90
Entrez ID: 79693
|
Does Knockout of COX6B1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
COX6B1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: COX6B1 (cytochrome c oxidase subunit 6B1)
Type: protein-coding
Summary: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIb. Mutations in this gene are associated with severe infantile encephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 and COX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2, respectively. [provided by RefSeq, Jan 2010].
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, cytochrome c to oxygen, oxidative phosphorylation, proton transmembrane transport, substantia nigra development; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Homo sapiens (human), Metabolism, Mitochondrial CIV Assembly, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Homo sapiens (human), Transcriptional Regulation by TP53
UniProt: P14854
Entrez ID: 1340
|
Does Activation of SLIT3 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
SLIT3
|
response to virus
|
Hepatoma Cell Line
|
Gene: SLIT3 (slit guidance ligand 3)
Type: protein-coding
Summary: The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: Roundabout signaling pathway, animal organ morphogenesis, aortic valve morphogenesis, apoptotic process involved in luteolysis, atrioventricular valve morphogenesis, axon extension involved in axon guidance, axon guidance, cell differentiation, cellular response to hormone stimulus, chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration, negative chemotaxis, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of chemokine-mediated signaling pathway, negative regulation of gene expression, nervous system development, response to cortisol, ventricular septum morphogenesis; MF: Roundabout binding, calcium ion binding, heparin binding; CC: extracellular region, extracellular space, mitochondrion
Pathways: Axon guidance, Axon guidance - Homo sapiens (human), Developmental Biology, Nervous system development, Netrin-1 signaling, Regulation of commissural axon pathfinding by SLIT and ROBO, Signaling by ROBO receptors, Spinal Cord Injury
UniProt: O75094
Entrez ID: 6586
|
Does Knockout of PARN in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
PARN
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: PARN (poly(A)-specific ribonuclease)
Type: protein-coding
Summary: The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: RNA catabolic process, RNA modification, box H/ACA sno(s)RNA 3'-end processing, female gamete generation, lncRNA processing, mRNA catabolic process, miRNA catabolic process, negative regulation of macromolecule metabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA poly(A) tail shortening, poly(A)-dependent snoRNA 3'-end processing, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of telomere maintenance via telomerase, priRNA 3'-end processing, regulation of RNA stability, regulation of telomerase RNA localization to Cajal body, siRNA 3'-end processing, telomerase RNA stabilization; MF: 3'-5'-RNA exonuclease activity, RNA binding, cation binding, exonuclease activity, hydrolase activity, mRNA 3'-UTR binding, metal ion binding, nuclease activity, nucleic acid binding, poly(A)-specific ribonuclease activity, protein binding, protein kinase binding, telomerase RNA binding; CC: cytoplasm, cytosol, glutamatergic synapse, nuclear speck, nucleolus, nucleus, postsynapse
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, Cellular responses to stimuli, Cellular responses to stress, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Lung fibrosis, Metabolism of RNA, PERK regulates gene expression, RNA degradation - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Unfolded Protein Response (UPR)
UniProt: O95453
Entrez ID: 5073
|
Does Knockout of PIK3C3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
PIK3C3
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3)
Type: protein-coding
Summary: Enables 1-phosphatidylinositol-3-kinase activity. Involved in early endosome to late endosome transport and regulation of cytokinesis. Acts upstream of or within autophagy and protein lipidation. Located in autolysosome; late endosome; and midbody. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagosome assembly, autophagosome maturation, autophagy, cell division, cellular response to glucose starvation, cellular response to starvation, early endosome to late endosome transport, endocytosis, endosome organization, host-mediated activation of viral genome replication, interleukin-6-mediated signaling pathway, lipid metabolic process, macroautophagy, pexophagy, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, positive regulation of natural killer cell mediated cytotoxicity, positive regulation of protein lipidation, protein localization to phagophore assembly site, protein processing, protein targeting to lysosome, regulation of autophagy, regulation of cytokinesis, regulation of macroautophagy, response to L-leucine, synaptic vesicle endocytosis, type II interferon-mediated signaling pathway; MF: 1-phosphatidylinositol-3-kinase activity, ATP binding, kinase activity, nucleotide binding, phosphatidylinositol kinase activity, phosphotransferase activity, alcohol group as acceptor, protein binding, protein kinase activity, transferase activity; CC: GABA-ergic synapse, autolysosome, autophagosome, axoneme, cytoplasm, cytoplasmic vesicle, cytosol, endosome, glutamatergic synapse, late endosome, membrane, midbody, peroxisome, phagocytic vesicle, phagocytic vesicle membrane, phagophore assembly site, phosphatidylinositol 3-kinase complex, class III, phosphatidylinositol 3-kinase complex, class III, type I, phosphatidylinositol 3-kinase complex, class III, type II, plasma membrane, postsynapse, postsynaptic endosome, presynaptic endosome
Pathways: 3-phosphoinositide biosynthesis, AMP-activated protein kinase (AMPK) signaling, Adaptive Immune System, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Angiopoietin Like Protein 8 Regulatory Pathway, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Apelin signaling pathway - Homo sapiens (human), Autophagy, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, DNA damage response (only ATM dependent), Disease, Early SARS-CoV-2 Infection Events, Huntington disease - Homo sapiens (human), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Infectious disease, Innate Immune System, Inositol Metabolism, Inositol phosphate metabolism - Homo sapiens (human), Insulin Signaling, Insulin receptor signalling cascade, Joubert syndrome, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Macroautophagy, Metabolism, Metabolism of lipids, Microglia Pathogen Phagocytosis Pathway, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Osteoblast differentiation, PI Metabolism, PI3K Cascade, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phagosome - Homo sapiens (human), Phosphatidylinositol Phosphate Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipid metabolism, RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, Regulation of Actin Cytoskeleton, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Salmonella infection - Homo sapiens (human), Senescence and Autophagy in Cancer, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Spinocerebellar ataxia - Homo sapiens (human), Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Translation of Replicase and Assembly of the Replication Transcription Complex, Tuberculosis - Homo sapiens (human), Viral Infection Pathways, superpathway of inositol phosphate compounds
UniProt: Q8NEB9
Entrez ID: 5289
|
Does Knockout of HRH4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
HRH4
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: HRH4 (histamine receptor H4)
Type: protein-coding
Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway, chemical synaptic transmission, inflammatory response, positive regulation of cytosolic calcium ion concentration, regulation of MAPK cascade, signal transduction; MF: G protein-coupled receptor activity, histamine receptor activity, neurotransmitter receptor activity; CC: dendrite, membrane, plasma membrane, synapse
Pathways: Amine ligand-binding receptors, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Other, Histamine receptors, Neuroactive ligand-receptor interaction - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q9H3N8
Entrez ID: 59340
|
Does Activation of OS9 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
OS9
|
protein/peptide accumulation
|
T cell
|
Gene: OS9 (OS9 endoplasmic reticulum lectin)
Type: protein-coding
Summary: This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ERAD pathway, endoplasmic reticulum unfolded protein response, intracellular protein localization, negative regulation of retrograde protein transport, ER to cytosol, protein retention in ER lumen, protein targeting, protein ubiquitination, response to endoplasmic reticulum stress, retrograde protein transport, ER to cytosol, ubiquitin-dependent protein catabolic process; MF: carbohydrate binding, glycosylation-dependent protein binding, protease binding, protein binding; CC: Hrd1p ubiquitin ligase complex, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, Co-inhibition by PD-1, Defective CFTR causes cystic fibrosis, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, ER Quality Control Compartment (ERQC), Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, Immune System, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by Hedgehog, Transport of small molecules
UniProt: Q13438
Entrez ID: 10956
|
Does Knockout of SLC35G3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
SLC35G3
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: SLC35G3 (solute carrier family 35 member G3)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane
Pathways:
UniProt: Q8N808
Entrez ID: 146861
|
Does Knockout of HSCB in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
HSCB
|
cell proliferation
|
Bladder Carcinoma
|
Gene: HSCB (HscB mitochondrial iron-sulfur cluster cochaperone)
Type: protein-coding
Summary: This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: [2Fe-2S] cluster assembly, iron-sulfur cluster assembly, primitive erythrocyte differentiation, primitive hemopoiesis, protein complex oligomerization; MF: ATPase activator activity, identical protein binding, metal ion binding, molecular_function, protein binding, protein-folding chaperone binding; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Complex III assembly, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Mitochondrial protein import, Protein localization, Respiratory electron transport
UniProt: Q8IWL3
Entrez ID: 150274
|
Does Knockout of AP4E1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
AP4E1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: AP4E1 (adaptor related protein complex 4 subunit epsilon 1)
Type: protein-coding
Summary: This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: establishment of protein localization, intracellular protein localization, intracellular protein transport, protein targeting, protein transport, vesicle-mediated transport; MF: cargo adaptor activity, protein binding; CC: AP-4 adaptor complex, Golgi apparatus, endosome lumen, membrane, membrane coat, trans-Golgi network, trans-Golgi network membrane
Pathways: Golgi Associated Vesicle Biogenesis, Lysosome - Homo sapiens (human), Lysosome Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q9UPM8
Entrez ID: 23431
|
Does Knockout of HS6ST2 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
HS6ST2
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: HS6ST2 (heparan sulfate 6-O-sulfotransferase 2)
Type: protein-coding
Summary: Heparan sulfate proteoglycans are ubiquitous components of the cell surface, extracellular matrix, and basement membranes, and interact with various ligands to influence cell growth, differentiation, adhesion, and migration. This gene encodes a member of the heparan sulfate (HS) sulfotransferase gene family, which catalyze the transfer of sulfate to HS. Different family members and isoforms are thought to synthesize heparan sulfates with tissue-specific structures and functions. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: heparan sulfate proteoglycan biosynthetic process; MF: heparan sulfate 6-sulfotransferase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human), Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metapathway biotransformation Phase I and II, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: Q96MM7
Entrez ID: 90161
|
Does Knockout of LILRB5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
LILRB5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: LILRB5 (leukocyte immunoglobulin like receptor B5)
Type: protein-coding
Summary: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adaptive immune response, cell surface receptor signaling pathway, cytokine-mediated signaling pathway, defense response, immune response-regulating signaling pathway, immune system process; MF: inhibitory MHC class I receptor activity, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Adaptive Immune System, B cell receptor signaling pathway - Homo sapiens (human), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Osteoclast differentiation - Homo sapiens (human)
UniProt: O75023
Entrez ID: 10990
|
Does Knockout of PRMT1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
PRMT1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PRMT1 (protein arginine methyltransferase 1)
Type: protein-coding
Summary: This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: BMP signaling pathway, DNA damage response, RNA splicing, TORC1 signaling, cardiac muscle tissue development, cell surface receptor signaling pathway, cellular response to amino acid starvation, cellular response to methionine, cellular response to nutrient levels, chromatin remodeling, double-strand break repair via homologous recombination, in utero embryonic development, membraneless organelle assembly, methylation, negative regulation of BMP signaling pathway, negative regulation of JNK cascade, negative regulation of TORC1 signaling, negative regulation of double-strand break repair via homologous recombination, negative regulation of megakaryocyte differentiation, negative regulation of translation, negative regulation of translational initiation, neuron projection development, peptidyl-arginine methylation, positive regulation of TORC1 signaling, positive regulation of cell population proliferation, positive regulation of double-strand break repair via homologous recombination, positive regulation of erythrocyte differentiation, positive regulation of hemoglobin biosynthetic process, positive regulation of p38MAPK cascade, positive regulation of translation, protein homooligomerization, protein localization to lysosome, protein methylation, regulation of BMP signaling pathway, regulation of DNA-templated transcription, regulation of megakaryocyte differentiation, viral protein processing; MF: GATOR1 complex binding, N-methyltransferase activity, RNA binding, S-adenosyl-L-methionine binding, enzyme binding, histone H4 methyltransferase activity, histone H4R3 methyltransferase activity, histone methyltransferase activity, identical protein binding, methyl-CpG binding, methyltransferase activity, mitogen-activated protein kinase p38 binding, protein binding, protein methyltransferase activity, protein-arginine N-methyltransferase activity, protein-arginine omega-N asymmetric methyltransferase activity, protein-arginine omega-N monomethyltransferase activity, transferase activity; CC: cytoplasm, cytosol, lysosomal membrane, lysosome, membrane, methylosome, nucleoplasm, nucleus
Pathways: 16p11.2 distal deletion syndrome, AndrogenReceptor, Direct p53 effectors, Energy Metabolism, FoxO signaling pathway - Homo sapiens (human), Glucagon signaling pathway - Homo sapiens (human), Interferon type I signaling pathways, NO metabolism in cystic fibrosis, Tryptophan metabolism, btg family proteins and cell cycle regulation, mRNA Processing
UniProt: Q99873
Entrez ID: 3276
|
Does Knockout of ALG11 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
ALG11
|
cell proliferation
|
Bladder Carcinoma
|
Gene: ALG11 (ALG11 alpha-1,2-mannosyltransferase)
Type: protein-coding
Summary: This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation; MF: GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity, alpha-1,2-mannosyltransferase activity, glycosyltransferase activity, protein binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective ALG11 causes CDG-1p, Disease, Diseases associated with N-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), Post-translational protein modification, Various types of N-glycan biosynthesis - Homo sapiens (human)
UniProt: Q2TAA5
Entrez ID: 440138
|
Does Knockout of UBE2M in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
UBE2M
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: UBE2M (ubiquitin conjugating enzyme E2 M)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: post-translational protein modification, protein modification by small protein conjugation, protein modification process, protein neddylation, regulation of postsynapse assembly; MF: ATP binding, NEDD8 conjugating enzyme activity, NEDD8 transferase activity, nucleotide binding, protein binding, transferase activity, ubiquitin-like protein transferase activity, ubiquitin-protein transferase activity; CC: cytosol, glutamatergic synapse, nucleoplasm, nucleus, postsynapse, presynapse
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, Immune System, Innate Immune System, Metabolism of proteins, NIK-->noncanonical NF-kB signaling, Neddylation, Post-translational protein modification, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, TNFR2 non-canonical NF-kB pathway, Ubiquitin mediated proteolysis - Homo sapiens (human), Validated nuclear estrogen receptor alpha network, Validated nuclear estrogen receptor beta network, regulation of p27 phosphorylation during cell cycle progression
UniProt: P61081
Entrez ID: 9040
|
Does Knockout of SUPT4H1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
SUPT4H1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit)
Type: protein-coding
Summary: This gene encodes the small subunit of DRB (5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole) sensitivity-inducing factor (DSIF) complex, which regulates mRNA processing and transcription elongation by RNA polymerase II. The encoded protein is localized to the nucleus and interacts with the large subunit (SUPT5H) to form the DSIF complex. Related pseudogenes have been identified on chromosomes 2 and 12. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: negative regulation of DNA-templated transcription, elongation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription elongation by RNA polymerase II, transcription elongation by RNA polymerase II, transcription elongation-coupled chromatin remodeling; MF: RNA polymerase II complex binding, metal ion binding, protein binding, protein heterodimerization activity, zinc ion binding; CC: DSIF complex, nucleoplasm, nucleus
Pathways: Abortive elongation of HIV-1 transcript in the absence of Tat, Disease, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV elongation arrest and recovery, Infectious disease, Initiation of transcription and translation elongation at the HIV-1 LTR, Late Phase of HIV Life Cycle, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA polymerase II transcribes snRNA genes, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcriptional Regulation by TP53, Viral Infection Pathways
UniProt: P63272
Entrez ID: 6827
|
Does Knockout of SELP in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
SELP
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: SELP (selectin P)
Type: protein-coding
Summary: This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell-cell adhesion, cell-cell adhesion via plasma-membrane adhesion molecules, defense response to Gram-negative bacterium, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, inflammatory response, leukocyte cell-cell adhesion, leukocyte migration, leukocyte tethering or rolling, positive regulation of leukocyte migration, positive regulation of leukocyte tethering or rolling, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of platelet activation, regulation of integrin activation, response to cytokine, response to lipopolysaccharide; MF: calcium ion binding, calcium-dependent protein binding, carbohydrate binding, fucose binding, glycosphingolipid binding, heparin binding, integrin binding, lipopolysaccharide binding, metal ion binding, oligosaccharide binding, protein binding, sialic acid binding; CC: external side of plasma membrane, extracellular space, membrane, plasma membrane, platelet alpha granule membrane, platelet dense granule membrane
Pathways: Cell adhesion molecules - Homo sapiens (human), Cell surface interactions at the vascular wall, Cells and molecules involved in local acute inflammatory response, Complement system, Coronavirus disease - COVID-19 - Homo sapiens (human), Hemostasis, IL4-mediated signaling events, Lipid and atherosclerosis - Homo sapiens (human), Malaria - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, Spinal Cord Injury, Staphylococcus aureus infection - Homo sapiens (human), amb2 Integrin signaling
UniProt: P16109
Entrez ID: 6403
|
Does Knockout of OR9G4 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
OR9G4
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: OR9G4 (olfactory receptor family 9 subfamily G member 4)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGQ1
Entrez ID: 283189
|
Does Knockout of POLD3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
POLD3
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: POLD3 (DNA polymerase delta 3, accessory subunit)
Type: protein-coding
Summary: This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA synthesis involved in DNA repair, DNA synthesis involved in UV-damage excision repair, DNA-templated DNA replication, error-prone translesion synthesis, mismatch repair, nucleotide-excision repair, DNA gap filling; MF: DNA-directed DNA polymerase activity, protein binding, protein-macromolecule adaptor activity; CC: cytoplasm, delta DNA polymerase complex, nucleoplasm, nucleus, zeta DNA polymerase complex
Pathways: Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Pyrimidine metabolism, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q15054
Entrez ID: 10714
|
Does Knockout of OR2J3 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
OR2J3
|
response to virus
|
Lung Cancer Cell Line
|
Gene: OR2J3 (olfactory receptor family 2 subfamily J member 3)
Type: protein-coding
Summary: This gene encodes a G-protein-coupled receptor (GPCR) that functions as an olfactory receptor. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The protein encoded by this gene responds to cis-3-hexen-1-ol, which is released by wounded plants, including cut grass. This gene is situated in a cluster of similar olfactory-receptor coding genes on chromosome 6. [provided by RefSeq, May 2013].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, GPCRs, Class A Rhodopsin-like, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: O76001
Entrez ID: 442186
|
Does Knockout of MYBL2 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
MYBL2
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: MYBL2 (MYB proto-oncogene like 2)
Type: protein-coding
Summary: The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, mitotic cell cycle, mitotic spindle assembly, positive regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: Myb complex, cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cellular senescence - Homo sapiens (human), E2F transcription factor network, EGF-EGFR signaling pathway, G0 and Early G1, G2/M Transition, Gastric Cancer Network 1, Gene expression (Transcription), Generic Transcription Pathway, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Polo-like kinase mediated events, RNA Polymerase II Transcription, TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
UniProt: P10244
Entrez ID: 4605
|
Does Knockout of EIF2B1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
EIF2B1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha)
Type: protein-coding
Summary: This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: T cell receptor signaling pathway, cytoplasmic translational initiation, oligodendrocyte development, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, identical protein binding, protein binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex, membrane, plasma membrane
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Translation, Translation Factors
UniProt: Q14232
Entrez ID: 1967
|
Does Knockout of TFIP11 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
TFIP11
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: TFIP11 (tuftelin interacting protein 11)
Type: protein-coding
Summary: This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].
Gene Ontology: BP: RNA processing, RNA splicing, biomineral tissue development, mRNA processing, mRNA splicing, via spliceosome, negative regulation of double-strand break repair via nonhomologous end joining, negative regulation of protein-containing complex assembly, protection from non-homologous end joining at telomere, spliceosomal complex disassembly; MF: nucleic acid binding, protein binding; CC: U2-type post-mRNA release spliceosomal complex, catalytic step 2 spliceosome, chromosome, telomeric region, cytoplasm, extracellular matrix, nuclear speck, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9UBB9
Entrez ID: 24144
|
Does Knockout of SRP68 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
SRP68
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: SRP68 (signal recognition particle 68)
Type: protein-coding
Summary: This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012].
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, response to xenobiotic stimulus; MF: 7S RNA binding, RNA binding, endoplasmic reticulum signal peptide binding, protein binding, protein domain specific binding, ribosome binding, signal recognition particle binding; CC: cytoplasm, cytosol, endoplasmic reticulum, focal adhesion, nucleolus, nucleus, ribonucleoprotein complex, ribosome, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Homo sapiens (human), SRP-dependent cotranslational protein targeting to membrane, Translation
UniProt: Q9UHB9
Entrez ID: 6730
|
Does Knockout of PSENEN in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
PSENEN
|
cell proliferation
|
T-lymphoma cell line
|
Gene: PSENEN (presenilin enhancer, gamma-secretase subunit)
Type: protein-coding
Summary: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: Notch receptor processing, Notch signaling pathway, amyloid precursor protein catabolic process, amyloid precursor protein metabolic process, amyloid-beta formation, membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, positive regulation of endopeptidase activity, protein processing; MF: endopeptidase activator activity, enzyme binding, protein binding; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome membrane, gamma-secretase complex, membrane, plasma membrane, presynaptic membrane
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amyloid fiber formation, Axon guidance, Cell death signalling via NRAGE, NRIF and NADE, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Death Receptor Signaling, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, Metabolism of proteins, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, NOTCH4 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Nervous system development, Noncanonical activation of NOTCH3, Notch, Notch Signaling Pathway Netpath, Notch signaling pathway, Notch signaling pathway - Homo sapiens (human), Nuclear signaling by ERBB4, Presenilin action in Notch and Wnt signaling, Regulated proteolysis of p75NTR, Signal Transduction, Signaling by ERBB4, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by NOTCH4, Signaling by Receptor Tyrosine Kinases, Signaling by TGFB family members, Signaling by TGFBR3, Syndecan-3-mediated signaling events, TGFBR3 PTM regulation, p75 NTR receptor-mediated signalling, p75(NTR)-mediated signaling
UniProt: Q9NZ42
Entrez ID: 55851
|
Does Knockout of KATNB1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
KATNB1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: KATNB1 (katanin regulatory subunit B1)
Type: protein-coding
Summary: Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell division, cytoplasmic microtubule organization, microtubule depolymerization, microtubule severing, mitotic chromosome movement towards spindle pole, negative regulation of microtubule depolymerization, positive regulation of apoptotic process, positive regulation of microtubule depolymerization, positive regulation of neuron projection development, protein targeting; MF: ATPase regulator activity, dynein complex binding, microtubule binding, protein binding, protein heterodimerization activity; CC: axon, centrosome, cytoplasm, cytoskeleton, cytosol, growth cone, katanin complex, membrane, microtubule, microtubule cytoskeleton, microtubule organizing center, midbody, neuronal cell body, nucleus, plasma membrane, spindle, spindle pole
Pathways: Genes related to primary cilium development (based on CRISPR)
UniProt: Q9BVA0
Entrez ID: 10300
|
Does Knockout of FOLH1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
FOLH1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: FOLH1 (folate hydrolase 1)
Type: protein-coding
Summary: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: folic acid-containing compound metabolic process, glutamate biosynthetic process, intestinal folate absorption, positive regulation of glutamate receptor signaling pathway, proteolysis; MF: Ac-Asp-Glu binding, carboxypeptidase activity, catalytic activity, dipeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, protein binding, tetrahydrofolyl-poly(glutamate) polymer binding; CC: cell surface, cytoplasm, extracellular exosome, membrane, plasma membrane
Pathways: Alanine, aspartate and glutamate metabolism - Homo sapiens (human), Aspartate and asparagine metabolism, Male infertility, Metabolism, Metabolism of amino acids and derivatives, One-carbon metabolism, Vitamin digestion and absorption - Homo sapiens (human)
UniProt: Q04609
Entrez ID: 2346
|
Does Knockout of ZSCAN9 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
ZSCAN9
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ZSCAN9 (zinc finger and SCAN domain containing 9)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: O15535
Entrez ID: 7746
|
Does Knockout of SF3B3 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
SF3B3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SF3B3 (splicing factor 3b subunit 3)
Type: protein-coding
Summary: This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, negative regulation of protein catabolic process, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing; MF: U2 snRNA binding, nucleic acid binding, protein binding, protein-containing complex binding; CC: SAGA complex, U12-type spliceosomal complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q15393
Entrez ID: 23450
|
Does Knockout of SEMG1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
SEMG1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SEMG1 (semenogelin 1)
Type: protein-coding
Summary: The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, coagulation, insemination, killing of cells of another organism, negative regulation of calcium ion import, negative regulation of flagellated sperm motility, positive regulation of serine-type endopeptidase activity, sperm capacitation; MF: protein binding, zinc ion binding; CC: acrosomal vesicle, extracellular exosome, extracellular region, extracellular space, nucleus, protein-containing complex
Pathways: Male infertility
UniProt: P04279
Entrez ID: 6406
|
Does Knockout of SMAD2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
SMAD2
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: SMAD2 (SMAD family member 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: DNA-templated transcription, SMAD protein signal transduction, activin receptor signaling pathway, anatomical structure morphogenesis, anterior/posterior pattern specification, aortic valve morphogenesis, cell differentiation, cell fate commitment, cell population proliferation, determination of left/right asymmetry in lateral mesoderm, developmental growth, embryonic cranial skeleton morphogenesis, embryonic foregut morphogenesis, embryonic pattern specification, endocardial cushion morphogenesis, endoderm development, endoderm formation, gastrulation, heart development, in utero embryonic development, insulin secretion, intracellular signal transduction, lung development, mesenchyme development, mesoderm development, mesoderm formation, negative regulation of DNA-templated transcription, negative regulation of cell differentiation, negative regulation of gene expression, negative regulation of ossification, nodal signaling pathway, odontoblast differentiation, organ growth, pancreas development, paraxial mesoderm morphogenesis, pattern specification process, pericardium development, positive regulation of BMP signaling pathway, positive regulation of DNA-templated transcription, positive regulation of epithelial to mesenchymal transition, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, post-embryonic development, primary miRNA processing, pulmonary valve morphogenesis, regionalization, regulation of DNA-templated transcription, regulation of multicellular organismal process, regulation of transforming growth factor beta receptor signaling pathway, response to cholesterol, response to glucose, response to transforming growth factor beta, secondary palate development, transforming growth factor beta receptor signaling pathway, trophoblast cell migration, ureteric bud development, zygotic specification of dorsal/ventral axis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, I-SMAD binding, R-SMAD binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, SMAD binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, co-SMAD binding, disordered domain specific binding, double-stranded DNA binding, identical protein binding, metal ion binding, phosphatase binding, protein binding, tau protein binding, transforming growth factor beta receptor binding, type I transforming growth factor beta receptor binding, ubiquitin protein ligase binding; CC: SMAD protein complex, activin responsive factor complex, chromatin, cytoplasm, cytosol, heteromeric SMAD protein complex, homomeric SMAD protein complex, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: AGE-RAGE pathway, AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Alpha6Beta4Integrin, Apelin signaling pathway - Homo sapiens (human), Canonical and non-canonical TGF-B signaling, Cell cycle, Cell cycle - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Chagas disease - Homo sapiens (human), Chromosomal and microsatellite instability in colorectal cancer, Colorectal cancer - Homo sapiens (human), Deubiquitination, Developmental Biology, Diabetic cardiomyopathy - Homo sapiens (human), Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Downregulation of TGF-beta receptor signaling, EGFR1, Endocytosis - Homo sapiens (human), Endoderm differentiation, Envelope proteins and their potential roles in EDMD physiopathology, Epithelial to mesenchymal transition in colorectal cancer, Extracellular vesicle-mediated signaling in recipient cells, FOXO-mediated transcription, FOXO-mediated transcription of cell cycle genes, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Formation of axial mesoderm, Formation of definitive endoderm, Gastric cancer - Homo sapiens (human), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, Germ layer formation at gastrulation, Glypican 1 network, Hepatitis B infection, Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Hypothesized Pathways in Pathogenesis of Cardiovascular Disease, Inflammatory bowel disease - Homo sapiens (human), LDLRAD4 and what we know about it, Loss of Function of SMAD2/3 in Cancer, Loss of Function of SMAD4 in Cancer, Loss of Function of TGFBR1 in Cancer, Mesodermal commitment pathway, Metabolism of proteins, Neovascularisation processes, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways Regulating Hippo Signaling, Pathways in cancer - Homo sapiens (human), Post-translational protein modification, Proteoglycans in cancer - Homo sapiens (human), RNA Polymerase II Transcription, Regucalcin in proximal tubule epithelial kidney cells, Regulation of cytoplasmic and nuclear SMAD2/3 signaling, Regulation of nuclear SMAD2/3 signaling, Relaxin signaling pathway - Homo sapiens (human), SMAD2/3 MH2 Domain Mutants in Cancer, SMAD2/3 Phosphorylation Motif Mutants in Cancer, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, SMAD4 MH2 Domain Mutants in Cancer, Signal Transduction, Signaling by Activin, Signaling by NODAL, Signaling by TGF-beta Receptor Complex, Signaling by TGF-beta Receptor Complex in Cancer, Signaling by TGFB family members, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, TGF-beta Receptor Signaling, TGF-beta Signaling Pathway, TGF-beta receptor signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in skeletal dysplasias, TGF-beta signaling pathway - Homo sapiens (human), TGFBR1 KD Mutants in Cancer, TGF_beta_Receptor, Tgif disruption of Shh signaling, Th17 cell differentiation - Homo sapiens (human), The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation of pluripotent stem cells, Ub-specific processing proteases, Validated targets of C-MYC transcriptional repression, tgf beta signaling pathway
UniProt: Q15796
Entrez ID: 4087
|
Does Knockout of SNRPC in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
SNRPC
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: SNRPC (small nuclear ribonucleoprotein polypeptide C)
Type: protein-coding
Summary: This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: mRNA 5'-splice site recognition, mRNA splicing, via spliceosome, spliceosomal snRNP assembly; MF: RNA binding, U1 snRNA binding, mRNA binding, metal ion binding, nucleic acid binding, pre-mRNA 5'-splice site binding, protein binding, protein homodimerization activity, single-stranded RNA binding, zinc ion binding; CC: Cajal body, U1 snRNP, U2-type prespliceosome, commitment complex, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, spliceosomal assembly
UniProt: P09234
Entrez ID: 6631
|
Does Knockout of MRPS5 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
MRPS5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: MRPS5 (mitochondrial ribosomal protein S5)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: P82675
Entrez ID: 64969
|
Does Knockout of CHKB in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
CHKB
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: CHKB (choline kinase beta)
Type: protein-coding
Summary: Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: CDP-choline pathway, lipid metabolic process, muscle organ development, phosphatidylcholine biosynthetic process, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process; MF: ATP binding, choline kinase activity, ethanolamine kinase activity, kinase activity, nucleotide binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Choline metabolism in cancer - Homo sapiens (human), FOXA2 and FOXA3 transcription factor networks, Fatty acid beta-oxidation, Glycerolipids and Glycerophospholipids, Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Kennedy pathway from sphingolipids, Metabolism, Metabolism of lipids, One-carbon metabolism and related pathways, Phospholipid metabolism, Synthesis of PC, Synthesis of PE, mitochondrial L-carnitine shuttle, phosphatidylcholine biosynthesis, phosphatidylethanolamine biosynthesis II
UniProt: Q9Y259
Entrez ID: 1120
|
Does Knockout of VSTM4 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
VSTM4
|
response to virus
|
Lung Cancer Cell Line
|
Gene: VSTM4 (V-set and transmembrane domain containing 4)
Type: protein-coding
Summary: Predicted to act upstream of or within several processes, including endothelial cell migration; retina blood vessel maintenance; and vasculature development. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endothelial cell migration, endothelial cell proliferation, retina blood vessel maintenance, retina vasculature development in camera-type eye, sprouting angiogenesis, vasodilation; CC: extracellular region, membrane, plasma membrane
Pathways:
UniProt: Q8IW00
Entrez ID: 196740
|
Does Knockout of SLC5A1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
SLC5A1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SLC5A1 (solute carrier family 5 member 1)
Type: protein-coding
Summary: This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: D-glucose import across plasma membrane, D-glucose transmembrane transport, alpha-glucoside transport, chloride transmembrane transport, fucose transmembrane transport, galactose transmembrane transport, intestinal D-glucose absorption, intestinal hexose absorption, monoatomic ion transport, myo-inositol transport, pentose transmembrane transport, renal D-glucose absorption, sodium ion import across plasma membrane, sodium ion transport, transepithelial water transport, transmembrane transport, transport across blood-brain barrier; MF: D-glucose transmembrane transporter activity, D-glucose:sodium symporter activity, alpha-glucoside transmembrane transporter activity, fucose transmembrane transporter activity, galactose transmembrane transporter activity, galactose:sodium symporter activity, myo-inositol:sodium symporter activity, pentose transmembrane transporter activity, protein binding, solute:sodium symporter activity, symporter activity, transmembrane transporter activity, water transmembrane transporter activity; CC: Golgi apparatus, apical plasma membrane, brush border membrane, early endosome, extracellular exosome, intracellular vesicle, membrane, nuclear membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Bile secretion - Homo sapiens (human), Carbohydrate digestion and absorption - Homo sapiens (human), Cellular hexose transport, Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM), Digestion and absorption, Disease, Disorders of transmembrane transporters, Intestinal absorption, Intestinal hexose absorption, Lactose Degradation, Lactose Intolerance, Mineral absorption - Homo sapiens (human), NRF2 pathway, Nuclear Receptors Meta-Pathway, Proximal tubule transport, SLC transporter disorders, SLC-mediated transmembrane transport, Transport of small molecules, Trehalose Degradation
UniProt: P13866
Entrez ID: 6523
|
Does Knockout of MRPL43 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
MRPL43
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: MRPL43 (mitochondrial ribosomal protein L43)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene and the gene for a semaphorin class 4 protein (SEMA4G) overlap at map location 10q24.31 and are transcribed in opposite directions. Sequence analysis identified multiple transcript variants encoding at least four different protein isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways:
UniProt: Q8N983
Entrez ID: 84545
|
Does Knockout of ZNF607 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
ZNF607
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: ZNF607 (zinc finger protein 607)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q96SK3
Entrez ID: 84775
|
Does Knockout of CHM in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
CHM
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: CHM (CHM Rab escort protein)
Type: protein-coding
Summary: This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: intracellular protein transport, protein geranylgeranylation, protein targeting to membrane, small GTPase-mediated signal transduction, vesicle-mediated transport, visual perception; MF: GDP-dissociation inhibitor activity, GTPase activator activity, Rab geranylgeranyltransferase activity, protein binding, small GTPase binding; CC: Rab-protein geranylgeranyltransferase complex, cytoplasm, cytosol, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, RNA Polymerase II Transcription, Rab regulation of trafficking, TP53 Regulates Transcription of Cell Death Genes, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, Transcriptional Regulation by TP53, Vesicle-mediated transport
UniProt: P24386
Entrez ID: 1121
|
Does Knockout of DPPA2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
DPPA2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: DPPA2 (developmental pluripotency associated 2)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity. Predicted to be involved in system development. Predicted to act upstream of or within several processes, including lung-associated mesenchyme development; positive regulation of stem cell proliferation; and regulation of histone methylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: chromatin binding, protein binding; CC: nucleoplasm, nucleus
Pathways: Developmental Biology, Maternal to zygotic transition (MZT), Zygotic genome activation (ZGA)
UniProt: Q7Z7J5
Entrez ID: 151871
|
Does Knockout of TSC22D2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
TSC22D2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: TSC22D2 (TSC22 domain family member 2)
Type: protein-coding
Summary: Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within response to osmotic stress. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of cell cycle, regulation of transcription by RNA polymerase II, response to osmotic stress
Pathways:
UniProt: O75157
Entrez ID: 9819
|
Does Knockout of ATOH1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
ATOH1
|
response to virus
|
Hepatoma Cell Line
|
Gene: ATOH1 (atonal bHLH transcription factor 1)
Type: protein-coding
Summary: This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]
Gene Ontology: BP: Notch signaling pathway, auditory receptor cell fate determination, auditory receptor cell fate specification, axon development, axon guidance, brain development, cell differentiation, central nervous system development, central nervous system neuron differentiation, cerebral cortex development, epithelial cell apoptotic process, inner ear auditory receptor cell differentiation, inner ear development, inner ear morphogenesis, negative regulation of epithelial cell apoptotic process, negative regulation of gliogenesis, nervous system development, neuroblast migration, neuron fate commitment, neuron migration, positive regulation of inner ear auditory receptor cell differentiation, positive regulation of inner ear receptor cell differentiation, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of neuron differentiation, sensory organ development, system development, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, protein dimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: Q92858
Entrez ID: 474
|
Does Knockout of PCK1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
PCK1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PCK1 (phosphoenolpyruvate carboxykinase 1)
Type: protein-coding
Summary: This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: NLS-bearing protein import into nucleus, SREBP-SCAP complex retention in endoplasmic reticulum, cellular response to dexamethasone stimulus, cellular response to glucose stimulus, cellular response to insulin stimulus, cellular response to potassium ion starvation, dicarboxylic acid metabolic process, gluconeogenesis, glucose homeostasis, glucose metabolic process, glyceraldehyde-3-phosphate biosynthetic process, glycerol biosynthetic process from pyruvate, hepatocyte differentiation, lipid metabolic process, oxaloacetate metabolic process, peptidyl-serine phosphorylation, positive regulation of cholesterol biosynthetic process, positive regulation of lipid biosynthetic process, positive regulation of memory T cell differentiation, positive regulation of transcription by RNA polymerase II, propionate catabolic process, protein maturation, regulation of lipid biosynthetic process, response to bacterium, response to insulin, response to starvation, tricarboxylic acid metabolic process; MF: GTP binding, carboxy-lyase activity, carboxylic acid binding, kinase activity, lyase activity, magnesium ion binding, manganese ion binding, metal ion binding, nucleotide binding, phosphoenolpyruvate carboxykinase (GTP) activity, phosphoenolpyruvate carboxykinase activity, protein serine kinase activity (using GTP as donor), purine nucleotide binding, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, mitochondrion
Pathways: AMPK signaling pathway - Homo sapiens (human), Abacavir ADME, Abacavir metabolism, Adipocytokine signaling pathway - Homo sapiens (human), Adipogenesis, Amino Acid metabolism, Angiopoietin Like Protein 8 Regulatory Pathway, Citrate cycle (TCA cycle) - Homo sapiens (human), Developmental Biology, Drug ADME, Estrogen Receptor Pathway, FOXA2 and FOXA3 transcription factor networks, FOXO-mediated transcription, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, FoxO signaling pathway - Homo sapiens (human), Fructose-1,6-diphosphatase deficiency, Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling pathway - Homo sapiens (human), Gluconeogenesis, Glucose metabolism, Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, Insulin resistance - Homo sapiens (human), Insulin signaling pathway - Homo sapiens (human), Leigh Syndrome, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis , NR1H2 and NR1H3-mediated signaling, Nuclear Receptors Meta-Pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PPAR signaling pathway, PPAR signaling pathway - Homo sapiens (human), Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Primary hyperoxaluria II, PH2, Proximal tubule bicarbonate reclamation - Homo sapiens (human), Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency), Pyruvate Dehydrogenase Complex Deficiency, Pyruvate Metabolism, Pyruvate kinase deficiency, Pyruvate metabolism - Homo sapiens (human), RNA Polymerase II Transcription, Signal Transduction, Signaling by Nuclear Receptors, TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc), Transcriptional regulation of white adipocyte differentiation, Triosephosphate isomerase, gluconeogenesis
UniProt: P35558
Entrez ID: 5105
|
Does Knockout of TNS1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
TNS1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: TNS1 (tensin 1)
Type: protein-coding
Summary: The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cell-substrate junction assembly, fibroblast migration; MF: RNA binding, actin binding, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, zinc ion binding; CC: anchoring junction, cell surface, cell-substrate junction, cytoplasm, cytoskeleton, focal adhesion
Pathways: EGFR1, Integrin-linked kinase signaling, Integrin-mediated Cell Adhesion, erk and pi-3 kinase are necessary for collagen binding in corneal epithelia, integrin signaling pathway
UniProt: Q9HBL0
Entrez ID: 7145
|
Does Knockout of LCNL1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
LCNL1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: LCNL1 (lipocalin like 1)
Type: protein-coding
Summary: Predicted to enable small molecule binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q6ZST4
Entrez ID: 401562
|
Does Knockout of PUF60 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
PUF60
|
cell proliferation
|
Cancer Cell Line
|
Gene: PUF60 (poly(U) binding splicing factor 60)
Type: protein-coding
Summary: This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, apoptotic process, mRNA processing, mRNA splice site recognition, regulation of alternative mRNA splicing, via spliceosome; MF: DNA binding, RNA binding, cadherin binding, identical protein binding, nucleic acid binding, protein binding; CC: cell junction, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Spliceosome - Homo sapiens (human)
UniProt: Q9UHX1
Entrez ID: 22827
|
Does Knockout of TTK in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
TTK
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: TTK (TTK protein kinase)
Type: protein-coding
Summary: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009].
Gene Ontology: BP: chromosome segregation, female meiosis chromosome segregation, meiotic spindle assembly checkpoint signaling, mitotic spindle assembly checkpoint signaling, mitotic spindle organization, nuclear chromosome segregation, nuclear division, positive regulation of SMAD protein signal transduction, positive regulation of cell population proliferation, protein localization to chromosome, protein localization to kinetochore, protein localization to meiotic spindle midzone, repair of mitotic kinetochore microtubule attachment defect, spindle organization; MF: ATP binding, identical protein binding, kinase activity, kinetochore binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, kinetochore, membrane, nucleus, spindle
Pathways: Cell cycle, Cell cycle - Homo sapiens (human), Retinoblastoma gene in cancer
UniProt: P33981
Entrez ID: 7272
|
Does Knockout of PDCD5 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
PDCD5
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: PDCD5 (programmed cell death 5)
Type: protein-coding
Summary: This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010].
Gene Ontology: BP: apoptotic process, cellular response to transforming growth factor beta stimulus, negative regulation of protein folding, positive regulation of apoptotic process, positive regulation of gene expression, regulation of apoptotic process; MF: DNA binding, acetyltransferase activator activity, beta-tubulin binding, heparin binding, protein binding; CC: cytoplasm, cytosol, extracellular exosome, nucleus
Pathways:
UniProt: O14737
Entrez ID: 9141
|
Does Knockout of MDH2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
MDH2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: MDH2 (malate dehydrogenase 2)
Type: protein-coding
Summary: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: NAD+ metabolic process, aerobic respiration, carboxylic acid metabolic process, gluconeogenesis, malate metabolic process, malate-aspartate shuttle, tricarboxylic acid cycle; MF: L-malate dehydrogenase (NAD+) activity, L-malate dehydrogenase (NADP+) activity, RNA binding, catalytic activity, identical protein binding, malate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; CC: cytoplasm, extracellular exosome, membrane, mitochondrial matrix, mitochondrion, nucleus
Pathways: 2-ketoglutarate dehydrogenase complex deficiency, Aerobic respiration and respiratory electron transport, Amino Acid metabolism, Citrate cycle (TCA cycle) - Homo sapiens (human), Citric Acid Cycle, Citric acid cycle (TCA cycle), Congenital lactic acidosis, Cysteine and methionine metabolism - Homo sapiens (human), Fructose-1,6-diphosphatase deficiency, Fumarase deficiency, Gluconeogenesis, Glutaminolysis and Cancer, Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycolysis and Gluconeogenesis, Glyoxylate and dicarboxylate metabolism - Homo sapiens (human), Malate-Aspartate Shuttle, Malate-aspartate shuttle, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of proteins, Mitochondrial complex II deficiency, Mitochondrial protein degradation, NAD Metabolism in Oncogene-Induced Senescence and Mitochondrial Dysfunction-Associated Senescence, Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Pyruvate dehydrogenase deficiency (E2), Pyruvate dehydrogenase deficiency (E3), Pyruvate metabolism - Homo sapiens (human), Respiratory electron transport, TCA Cycle (aka Krebs or citric acid cycle), TCA cycle, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate, Triosephosphate isomerase, gluconeogenesis, malate-aspartate shuttle, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P40926
Entrez ID: 4191
|
Does Knockout of KBTBD4 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
KBTBD4
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: KBTBD4 (kelch repeat and BTB domain containing 4)
Type: protein-coding
Summary: kelch repeat and BTB domain containing 4
Gene Ontology:
Pathways:
UniProt: Q9NVX7
Entrez ID: 55709
|
Does Knockout of ARFIP2 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
ARFIP2
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: ARFIP2 (ARF interacting protein 2)
Type: protein-coding
Summary: Enables several functions, including GTP-dependent protein binding activity; membrane curvature sensor activity; and phosphatidylinositol-4-phosphate binding activity. Involved in actin cytoskeleton organization. Located in cell cortex; ruffle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin cytoskeleton organization, autophagy, intracellular protein localization, intracellular protein transport, lamellipodium assembly, mitophagy, protein localization to phagophore assembly site, regulation of Arp2/3 complex-mediated actin nucleation, ruffle organization, small GTPase-mediated signal transduction; MF: GTP binding, GTP-dependent protein binding, cadherin binding, identical protein binding, membrane curvature sensor activity, phosphatidylinositol-4-phosphate binding, phospholipid binding, protein binding, protein domain specific binding, small GTPase binding; CC: Golgi apparatus, cell cortex, cytoplasm, cytosol, membrane, nucleolus, plasma membrane, ruffle, trans-Golgi network membrane
Pathways: Arf1 pathway, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport, rac1 cell motility signaling pathway
UniProt: P53365
Entrez ID: 23647
|
Does Knockout of WDR83 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
WDR83
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: WDR83 (WD repeat domain 83)
Type: protein-coding
Summary: This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, inflammatory response to wounding, mRNA processing, mRNA splicing, via spliceosome, neural tube closure, placenta blood vessel development, regulation of canonical NF-kappaB signal transduction, response to hypoxia, response to lipopolysaccharide, response to wounding; CC: catalytic step 2 spliceosome, cytoplasm, endosome membrane, lysosome, nucleus, spliceosomal complex
Pathways: MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Signal Transduction
UniProt: Q9BRX9
Entrez ID: 84292
|
Does Knockout of NPAS2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
NPAS2
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: NPAS2 (neuronal PAS domain protein 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, central nervous system development, circadian regulation of gene expression, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of behavioral fear response, regulation of DNA-templated transcription, regulation of gene expression, regulation of transcription by RNA polymerase II, response to redox state, response to xenobiotic stimulus, rhythmic process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, Hsp90 protein binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: CLOCK-BMAL transcription complex, chromatin, cytoplasm, cytosol, nucleoplasm, nucleus, transcription regulator complex
Pathways: BMAL1:CLOCK,NPAS2 activates circadian expression, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Circadian rhythm - Homo sapiens (human), Circadian rhythm pathway, Expression of BMAL (ARNTL), CLOCK, and NPAS2, Heme signaling, Metabolism, Metabolism of lipids, PPARA activates gene expression, Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes, Regulation of lipid metabolism by PPARalpha, The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
UniProt: Q99743
Entrez ID: 4862
|
Does Knockout of FOXRED2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
FOXRED2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: FOXRED2 (FAD dependent oxidoreductase domain containing 2)
Type: protein-coding
Summary: Enables flavin adenine dinucleotide binding activity. Involved in ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERAD pathway; MF: flavin adenine dinucleotide binding, monooxygenase activity, oxidoreductase activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum lumen
Pathways:
UniProt: Q8IWF2
Entrez ID: 80020
|
Does Knockout of SGCD in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
SGCD
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SGCD (sarcoglycan delta)
Type: protein-coding
Summary: The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion homeostasis, calcium-mediated signaling, cardiac muscle cell contraction, cardiac muscle cell development, cardiac muscle contraction, cardiac muscle tissue development, coronary vasculature morphogenesis, heart contraction, heart process, muscle organ development, protein-containing complex localization; CC: Golgi membrane, cytoplasm, cytoskeleton, dystroglycan complex, dystrophin-associated glycoprotein complex, endoplasmic reticulum membrane, membrane, plasma membrane, sarcoglycan complex, sarcolemma, sarcoplasmic reticulum
Pathways: Acute viral myocarditis, Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Dilated cardiomyopathy - Homo sapiens (human), Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Hypertrophic cardiomyopathy - Homo sapiens (human), Non-integrin membrane-ECM interactions, Viral myocarditis - Homo sapiens (human)
UniProt: Q92629
Entrez ID: 6444
|
Does Knockout of DEGS2 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
DEGS2
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: DEGS2 (delta 4-desaturase, sphingolipid 2)
Type: protein-coding
Summary: This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: ceramide biosynthetic process, lipid metabolic process, sphinganine metabolic process, sphingolipid biosynthetic process; MF: oxidoreductase activity, sphingolipid C4-monooxygenase activity, sphingolipid delta-4 desaturase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Fabry disease, Gaucher Disease, Globoid Cell Leukodystrophy, Krabbe disease, Metabolism, Metabolism of lipids, Metachromatic Leukodystrophy (MLD), Sphingolipid Metabolism, Sphingolipid Metabolism (general overview), Sphingolipid Metabolism (integrated pathway), Sphingolipid de novo biosynthesis, Sphingolipid metabolism, Sphingolipid metabolism - Homo sapiens (human), Sphingolipid signaling pathway - Homo sapiens (human), ceramide <i>de novo</i> biosynthesis
UniProt: Q6QHC5
Entrez ID: 123099
|
Does Knockout of CASQ1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
CASQ1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CASQ1 (calsequestrin 1)
Type: protein-coding
Summary: This gene encodes the skeletal muscle specific member of the calsequestrin protein family. Calsequestrin functions as a luminal sarcoplasmic reticulum calcium sensor in both cardiac and skeletal muscle cells. This protein, also known as calmitine, functions as a calcium regulator in the mitochondria of skeletal muscle. This protein is absent in patients with Duchenne and Becker types of muscular dystrophy. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: endoplasmic reticulum organization, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of store-operated calcium channel activity, protein polymerization, regulation of release of sequestered calcium ion into cytosol, regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, regulation of sequestering of calcium ion, regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion, regulation of store-operated calcium entry, response to denervation involved in regulation of muscle adaptation, response to heat, response to muscle inactivity, sarcomere organization, skeletal muscle tissue development; MF: calcium ion binding, identical protein binding, metal ion binding, protein binding; CC: I band, T-tubule, Z disc, endoplasmic reticulum, membrane, mitochondrial matrix, mitochondrion, myofibril, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum lumen, sarcoplasmic reticulum membrane, smooth endoplasmic reticulum, terminal cisterna, terminal cisterna lumen
Pathways: Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Cardiac conduction, Ion channel transport, Ion homeostasis, Muscle contraction, Stimuli-sensing channels, Transport of small molecules
UniProt: P31415
Entrez ID: 844
|
Does Knockout of SLFN12 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
SLFN12
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: SLFN12 (schlafen family member 12)
Type: protein-coding
Summary: Predicted to act upstream of or within negative regulation of cell population proliferation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic signaling pathway, rRNA catabolic process; MF: RNA nuclease activity, hydrolase activity, protein binding, ribosome binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8IYM2
Entrez ID: 55106
|
Does Knockout of KANSL2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
KANSL2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: KANSL2 (KAT8 regulatory NSL complex subunit 2)
Type: protein-coding
Summary: Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in several cellular components, including actin cytoskeleton; cytosol; and nucleoplasm. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription; CC: NSL complex, actin cytoskeleton, cytosol, histone acetyltransferase complex, mitochondrion, nucleoplasm, nucleus, plasma membrane
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones
UniProt: Q9H9L4
Entrez ID: 54934
|
Does Knockout of ARHGDIG in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
ARHGDIG
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: ARHGDIG (Rho GDP dissociation inhibitor gamma)
Type: protein-coding
Summary: The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: Rho protein signal transduction, blastocyst hatching, negative regulation of cell adhesion, regulation of protein localization; MF: GDP-dissociation inhibitor activity, GTPase activator activity, GTPase regulator activity, Rho GDP-dissociation inhibitor activity, protein binding; CC: cytoplasm, cytoplasmic vesicle, cytosol, membrane, plasma membrane
Pathways: CDC42 GTPase cycle, Ectoderm Differentiation, G13 Signaling Pathway, Neurotrophin signaling pathway - Homo sapiens (human), RHO GTPase cycle, RHOB GTPase cycle, RHOG GTPase cycle, RHOH GTPase cycle, Regulation of RhoA activity, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vasopressin-regulated water reabsorption - Homo sapiens (human)
UniProt: Q99819
Entrez ID: 398
|
Does Knockout of PRAMEF10 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
PRAMEF10
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: PRAMEF10 (PRAME family member 10)
Type: protein-coding
Summary: Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: O60809
Entrez ID: 343071
|
Does Knockout of ORC3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
ORC3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ORC3 (origin recognition complex subunit 3)
Type: protein-coding
Summary: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, DNA replication initiation, glial cell proliferation, neural precursor cell proliferation, regulation of DNA replication; MF: DNA binding, DNA replication origin binding, protein binding; CC: DNA replication preinitiation complex, chromatin, chromosome, chromosome, telomeric region, nuclear body, nuclear origin of replication recognition complex, nuclear pre-replicative complex, nucleoplasm, nucleus, origin recognition complex
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the ORC complex at the origin of replication, Assembly of the pre-replicative complex, CDC6 association with the ORC:origin complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), DNA Replication, DNA Replication Pre-Initiation, E2F mediated regulation of DNA replication, E2F-enabled inhibition of pre-replication complex formation, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, cdk regulation of dna replication
UniProt: Q9UBD5
Entrez ID: 23595
|
Does Knockout of EIF3A in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
EIF3A
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: EIF3A (eukaryotic translation initiation factor 3 subunit A)
Type: protein-coding
Summary: Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and viral translational termination-reinitiation. Located in cytosol; nucleolus; and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: IRES-dependent viral translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, negative regulation of ERK1 and ERK2 cascade, translation, translation reinitiation, translational initiation, viral translational termination-reinitiation; MF: RNA binding, mRNA binding, protein binding, receptor tyrosine kinase binding, structural molecule activity, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3e, eukaryotic translation initiation factor 3 complex, eIF3m, membrane, microtubule, multi-eIF complex, nucleolus, nucleoplasm, organelle, postsynaptic density, protein-containing complex
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, IL2 signaling events mediated by PI3K, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, eukaryotic protein translation, internal ribosome entry pathway, mtor signaling pathway, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: Q14152
Entrez ID: 8661
|
Does Knockout of MAT2A in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
MAT2A
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: MAT2A (methionine adenosyltransferase 2A)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: S-adenosylmethionine biosynthetic process, TORC1 signaling, cellular response to amino acid starvation, cellular response to leukemia inhibitory factor, cellular response to methionine, cellular response to nutrient levels, negative regulation of TORC1 signaling, one-carbon metabolic process, positive regulation of TORC1 signaling, protein complex oligomerization, protein heterooligomerization, protein hexamerization, protein localization to lysosome, protein-containing complex localization; MF: ATP binding, identical protein binding, metal ion binding, methionine adenosyltransferase activity, nucleotide binding, protein binding, small molecule binding, transferase activity; CC: cytosol, methionine adenosyltransferase complex
Pathways: Betaine Metabolism, Biological oxidations, C-MYB transcription factor network, Cystathionine Beta-Synthase Deficiency, Cysteine and methionine metabolism - Homo sapiens (human), Glycine N-methyltransferase Deficiency, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, Metabolism, Methionine Adenosyltransferase Deficiency, Methionine De Novo and Salvage Pathway, Methionine Metabolism, Methylation, Methylation Pathways, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), One-carbon metabolism and related pathways, Phase II - Conjugation of compounds, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, S-adenosyl-L-methionine biosynthesis, Selenoamino Acid Metabolism, Spermidine and Spermine Biosynthesis, Trans-sulfuration and one-carbon metabolism, cysteine biosynthesis, methionine degradation, sarcosine oncometabolite pathway , superpathway of methionine degradation
UniProt: P31153
Entrez ID: 4144
|
Does Knockout of MED20 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
MED20
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: MED20 (mediator complex subunit 20)
Type: protein-coding
Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: DNA-templated transcription, RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II, skeletal muscle cell differentiation, transcription by RNA polymerase II; MF: DNA-directed RNA polymerase activity, protein binding, transcription coactivator activity, transcription coregulator activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, protein-containing complex
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9H944
Entrez ID: 9477
|
Does Knockout of FIP1L1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
FIP1L1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: FIP1L1 (factor interacting with PAPOLA and CPSF1)
Type: protein-coding
Summary: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
Gene Ontology: MF: RNA binding, protein binding; CC: cytosol, mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Disease, Diseases of signal transduction by growth factor receptors and second messengers, Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Signaling by PDGFR in disease, Signaling by cytosolic PDGFRA and PDGFRB fusion proteins, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q6UN15
Entrez ID: 81608
|
Does Knockout of GABRA1 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
GABRA1
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1)
Type: protein-coding
Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chloride transmembrane transport, chloride transport, gamma-aminobutyric acid signaling pathway, inhibitory synapse assembly, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of postsynaptic membrane potential, synaptic transmission, GABAergic; MF: GABA receptor activity, GABA-A receptor activity, GABA-gated chloride ion channel activity, benzodiazepine receptor activity, chloride channel activity, extracellular ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, signaling receptor activity, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: GABA receptor complex, GABA-A receptor complex, GABA-ergic synapse, chloride channel complex, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendrite membrane, dendritic spine, membrane, plasma membrane, postsynapse, postsynaptic membrane, postsynaptic specialization membrane, synapse
Pathways: Fragile X Syndrome, GABA receptor Signaling, GABA receptor activation, GABAergic synapse - Homo sapiens (human), Morphine addiction - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Homo sapiens (human), Retrograde endocannabinoid signaling - Homo sapiens (human), Serotonin and anxiety, Signal Transduction, Signaling by ERBB4, Signaling by Receptor Tyrosine Kinases, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Taste transduction - Homo sapiens (human), Transmission across Chemical Synapses, cardiac protection against ros, gamma-aminobutyric acid receptor life cycle pathway, mBDNF and proBDNF regulation of GABA neurotransmission
UniProt: P14867
Entrez ID: 2554
|
Does Knockout of ZNF292 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
ZNF292
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: ZNF292 (zinc finger protein 292)
Type: protein-coding
Summary: This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: O60281
Entrez ID: 23036
|
Does Knockout of UNC13A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
UNC13A
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: UNC13A (unc-13 homolog A)
Type: protein-coding
Summary: This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: cell differentiation, chemical synaptic transmission, dense core granule priming, exocytosis, neuronal dense core vesicle exocytosis, neurotransmitter secretion, positive regulation of dendrite extension, regulation of synaptic transmission, glutamatergic, synaptic transmission, glutamatergic, synaptic vesicle docking, synaptic vesicle priming; MF: calcium ion binding, calmodulin binding, diacylglycerol binding, metal ion binding, phospholipid binding, syntaxin-1 binding, zinc ion binding; CC: cell projection, cytoplasm, membrane, neuromuscular junction, neuron projection, plasma membrane, presynaptic active zone, presynaptic membrane, synapse, synaptic vesicle membrane, terminal bouton
Pathways: 16p11.2 proximal deletion syndrome, Synaptic Vesicle Pathway, Synaptic vesicle cycle - Homo sapiens (human)
UniProt: Q9UPW8
Entrez ID: 23025
|
Does Knockout of U2AF1 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
U2AF1
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: U2AF1 (U2 small nuclear RNA auxiliary factor 1)
Type: protein-coding
Summary: This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, RS domain binding, metal ion binding, nucleic acid binding, pre-mRNA 3'-splice site binding, protein binding, zinc ion binding; CC: Cajal body, U2AF complex, catalytic step 2 spliceosome, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Shigellosis - Homo sapiens (human), Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, spliceosomal assembly
UniProt: Q01081
Entrez ID: 7307
|
Does Knockout of VPS54 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
VPS54
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: VPS54 (VPS54 subunit of GARP complex)
Type: protein-coding
Summary: This gene encodes for a protein that in yeast forms part of a trimeric vacuolar-protein-sorting complex that is required for retrograde transport of proteins from prevacuoles to the late Golgi compartment. As in yeast, mammalian Vps54 proteins contain a coiled-coil region and dileucine motifs. Alternative splicing results in multiple transcript variants encoding different isoforms [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi to vacuole transport, L-glutamate import, apoptotic DNA fragmentation, astrocyte differentiation, cellular response to progesterone stimulus, gene expression, homeostasis of number of cells, homeostasis of number of cells within a tissue, in utero embryonic development, intracellular calcium ion homeostasis, intracellular protein localization, limb development, limb morphogenesis, lysosomal transport, microglia differentiation, mitochondrion organization, motor behavior, motor neuron apoptotic process, musculoskeletal movement, negative regulation of motor neuron apoptotic process, neural tissue regeneration, neurofilament cytoskeleton organization, neuroinflammatory response, neuromuscular synaptic transmission, neuron apoptotic process, neuron projection morphogenesis, post-embryonic forelimb morphogenesis, protein localization to cell surface, protein targeting to ER, protein targeting to lysosome, protein targeting to vacuole, protein transport, regulation of growth, respiratory electron transport chain, response to antibiotic, response to calcium ion, retrograde transport, endosome to Golgi, skeletal muscle tissue development, skeletal muscle tissue growth, spermatid differentiation, sphingolipid catabolic process, striated muscle contraction, synaptic transmission, GABAergic, synaptic transmission, glutamatergic, thrombin-activated receptor signaling pathway, ubiquitin recycling, vacuole organization, vesicle-mediated cholesterol transport; MF: protein binding, syntaxin binding; CC: GARP complex, Golgi apparatus, cytoplasm, cytosol, membrane, mitochondrion, nucleoplasm, perinuclear region of cytoplasm, synapse, trans-Golgi network, trans-Golgi network membrane
Pathways:
UniProt: Q9P1Q0
Entrez ID: 51542
|
Does Knockout of PRAC1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
PRAC1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PRAC1 (PRAC1 small nuclear protein)
Type: protein-coding
Summary: This gene is reported to be specifically expressed in prostate, rectum and distal colon. Sequence analysis suggests that it may play a regulatory role in the nucleus. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q96KF2
Entrez ID: 84366
|
Does Knockout of PRR7 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
PRR7
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: PRR7 (proline rich 7, synaptic)
Type: protein-coding
Summary: Enables long-chain fatty acid binding activity; protein tyrosine kinase binding activity; and ubiquitin-like protein ligase binding activity. Involved in negative regulation of protein ubiquitination; positive regulation of apoptotic process; and positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: T cell differentiation in thymus, adaptive immune response, alpha-beta T cell differentiation, immune system process, positive regulation of apoptotic process, postsynapse to nucleus signaling pathway, regulation of transcription by RNA polymerase I; MF: long-chain fatty acid binding, protein binding, protein tyrosine kinase binding, protein-containing complex binding, ubiquitin-like protein ligase binding; CC: cell projection, cytoplasm, cytosol, dendrite, glutamatergic synapse, membrane, neuron projection, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynaptic density, postsynaptic density membrane, postsynaptic density, intracellular component, postsynaptic membrane, synapse
Pathways:
UniProt: Q8TB68
Entrez ID: 80758
|
Does Knockout of RASA4 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
RASA4
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: RASA4 (RAS p21 protein activator 4)
Type: protein-coding
Summary: This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to calcium ion, intracellular signal transduction, negative regulation of GTPase activity, negative regulation of Ras protein signal transduction, regulation of intracellular signal transduction; MF: GTPase activator activity, metal ion binding, phospholipid binding, zinc ion binding; CC: cytoplasm, cytosol, membrane, plasma membrane
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of RAS by GAPs, Regulation of Ras family activation, Signal Transduction
UniProt: O43374
Entrez ID: 10156
|
Does Knockout of METTL15 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
METTL15
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: METTL15 (methyltransferase 15, mitochondrial 12S rRNA N4-cytidine)
Type: protein-coding
Summary: Predicted to enable rRNA (cytosine-N4-)-methyltransferase activity. Predicted to be involved in rRNA base methylation. Predicted to be located in mitochondrial matrix. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: methylation, rRNA base methylation; MF: methyltransferase activity, protein binding, rRNA (cytosine-N4-)-methyltransferase activity, transferase activity; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: A6NJ78
Entrez ID: 196074
|
Does Knockout of SLC12A9 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
SLC12A9
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SLC12A9 (solute carrier family 12 member 9)
Type: protein-coding
Summary: Predicted to enable potassium:chloride symporter activity. Predicted to be involved in cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell volume homeostasis, chloride ion homeostasis, chloride transmembrane transport, monoatomic ion transport, potassium ion homeostasis, potassium ion transmembrane transport, transmembrane transport; MF: chloride:monoatomic cation symporter activity, potassium:chloride symporter activity, transmembrane transporter activity; CC: extracellular exosome, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways:
UniProt: Q9BXP2
Entrez ID: 56996
|
Does Knockout of SETD7 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
SETD7
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SETD7 (SET domain containing 7, histone lysine methyltransferase)
Type: protein-coding
Summary: Enables histone-lysine N-methyltransferase activity and p53 binding activity. Involved in peptidyl-lysine dimethylation and peptidyl-lysine monomethylation. Acts upstream of or within cellular response to DNA damage stimulus and heterochromatin organization. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, chromatin organization, chromatin remodeling, heterochromatin organization, methylation, peptidyl-lysine dimethylation, peptidyl-lysine monomethylation, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of DNA-templated transcription, response to alcohol, response to ethanol; MF: chromatin binding, histone H3 methyltransferase activity, histone H3K4 monomethyltransferase activity, histone methyltransferase activity, methyltransferase activity, p53 binding, protein binding, protein-lysine N-methyltransferase activity, transferase activity; CC: chromosome, nucleolus, nucleoplasm, nucleus
Pathways: Carnitine Synthesis, Chromatin modifying enzymes, Chromatin organization, FoxO signaling pathway - Homo sapiens (human), Histone Modifications, Lysine degradation - Homo sapiens (human), PKMTs methylate histone lysines, Regulatory circuits of the STAT3 signaling pathway, p53 pathway
UniProt: Q8WTS6
Entrez ID: 80854
|
Does Inhibition of TMX2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
TMX2
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TMX2 (thioredoxin related transmembrane protein 2)
Type: protein-coding
Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: brain development; MF: disulfide oxidoreductase activity, identical protein binding, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q9Y320
Entrez ID: 51075
|
Does Knockout of HMGCS1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
HMGCS1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Type: protein-coding
Summary: Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: acetyl-CoA metabolic process, cholesterol biosynthetic process, cholesterol metabolic process, farnesyl diphosphate biosynthetic process, mevalonate pathway, isoprenoid biosynthetic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: acyltransferase activity, hydroxymethylglutaryl-CoA synthase activity, protein binding, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Activation of gene expression by SREBF (SREBP), Alendronate Action Pathway, Atorvastatin Action Pathway, Butanoate metabolism - Homo sapiens (human), CHILD Syndrome, Cerivastatin Action Pathway, Cholesterol Biosynthesis Pathway, Cholesterol biosynthesis, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Cholesteryl ester storage disease, Chondrodysplasia Punctata II, X Linked Dominant (CDPX2), Desmosterolosis, Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, FOXA2 and FOXA3 transcription factor networks, Fluvastatin Action Pathway, Hyper-IgD syndrome, Hypercholesterolemia, Ibandronate Action Pathway, Lovastatin Action Pathway, Lysosomal Acid Lipase Deficiency (Wolman Disease), Metabolism, Metabolism of lipids, Metabolism of steroids, Mevalonic aciduria, PPAR signaling pathway - Homo sapiens (human), PPARA activates gene expression, Pamidronate Action Pathway, Pravastatin Action Pathway, Regulation of cholesterol biosynthesis by SREBP (SREBF), Regulation of lipid metabolism by PPARalpha, Risedronate Action Pathway, Rosuvastatin Action Pathway, SREBF and miR33 in cholesterol and lipid homeostasis, Simvastatin Action Pathway, Smith-Lemli-Opitz Syndrome (SLOS), Steroid Biosynthesis, Sterol regulatory element-binding proteins (SREBP) signaling, Synthesis and degradation of ketone bodies - Homo sapiens (human), Terpenoid backbone biosynthesis - Homo sapiens (human), Valine, leucine and isoleucine degradation - Homo sapiens (human), Wolman disease, Zoledronate Action Pathway, ketogenesis, mevalonate pathway, srebp control of lipid synthesis, superpathway of cholesterol biosynthesis, superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
UniProt: Q01581
Entrez ID: 3157
|
Does Knockout of TIMM22 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
TIMM22
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: TIMM22 (translocase of inner mitochondrial membrane 22)
Type: protein-coding
Summary: Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: protein insertion into mitochondrial inner membrane, protein transmembrane transport, protein transport; MF: mitochondrion targeting sequence binding, protein binding, protein transmembrane transporter activity, protein transporter activity; CC: TIM22 mitochondrial import inner membrane insertion complex, membrane, mitochondrial inner membrane, mitochondrion
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial protein import, Protein localization
UniProt: Q9Y584
Entrez ID: 29928
|
Does Knockout of GRAMD1A in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
GRAMD1A
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: GRAMD1A (GRAM domain containing 1A)
Type: protein-coding
Summary: Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol. Located in cytosol; organelle membrane contact site; and plasma membrane. Is extrinsic component of cytoplasmic side of plasma membrane and intrinsic component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagy, cellular response to cholesterol, intracellular sterol transport, lipid transport; MF: cholesterol binding, cholesterol transfer activity, lipid binding, protein binding; CC: autophagosome, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, membrane, organelle membrane contact site, plasma membrane
Pathways:
UniProt: Q96CP6
Entrez ID: 57655
|
Does Knockout of CCT6A in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
CCT6A
|
cell proliferation
|
Melanoma Cell Line
|
Gene: CCT6A (chaperonin containing TCP1 subunit 6A)
Type: protein-coding
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: positive regulation of establishment of protein localization to telomere, positive regulation of protein localization to Cajal body, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, RNA binding, WD40-repeat domain binding, hydrolase activity, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: chaperonin-containing T-complex, cytoplasm, cytosol, extracellular exosome, microtubule
Pathways: 16p11.2 proximal deletion syndrome, Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Folding of actin by CCT/TriC, Formation of tubulin folding intermediates by CCT/TriC, Metabolism of proteins, Prefoldin mediated transfer of substrate to CCT/TriC, Protein folding, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P40227
Entrez ID: 908
|
Does Knockout of NCAPH2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
NCAPH2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NCAPH2 (non-SMC condensin II complex subunit H2)
Type: protein-coding
Summary: This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants.[provided by RefSeq, May 2010].
Gene Ontology: BP: T cell differentiation in thymus, chromosome condensation, female meiosis chromosome separation, female meiotic nuclear division, meiotic chromosome condensation, mitotic chromosome condensation, mitotic sister chromatid separation, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation; MF: chromatin binding, protein binding; CC: cell junction, chromosome, condensed chromosome, condensed nuclear chromosome, condensin complex, intercellular bridge, membrane, nucleoplasm, nucleus
Pathways: IL-18 signaling pathway
UniProt: Q6IBW4
Entrez ID: 29781
|
Does Knockout of GDAP1L1 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
GDAP1L1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: GDAP1L1 (ganglioside induced differentiation associated protein 1 like 1)
Type: protein-coding
Summary: The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several genes is upregulated, including one that encodes a protein termed ganglioside-induced differentiation-associated protein 1 (Gdap1). A similar gene was found in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The protein encoded by this gene is similar in sequence to the human GDAP1 protein. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been found for this gene. [provided by RefSeq, Feb 2012].
Gene Ontology:
Pathways:
UniProt: Q96MZ0
Entrez ID: 78997
|
Does Knockout of TIE1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
TIE1
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1)
Type: protein-coding
Summary: This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: angiogenesis, aortic valve morphogenesis, blood vessel development, branching involved in lymph vessel morphogenesis, cell surface receptor protein tyrosine kinase signaling pathway, in utero embryonic development, lymphatic endothelial cell differentiation, mesoderm development, negative regulation of angiogenesis, negative regulation of cell migration, plasma membrane fusion, positive regulation of angiogenesis, regulation of endothelial cell proliferation, regulation of extracellular matrix assembly, response to retinoic acid, signal transduction, tissue development, tissue remodeling, vasculogenesis; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: membrane, plasma membrane, receptor complex
Pathways: RAC1-PAK1-p38-MMP2 Pathway
UniProt: P35590
Entrez ID: 7075
|
Does Knockout of DDO in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
DDO
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: DDO (D-aspartate oxidase)
Type: protein-coding
Summary: The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2019].
Gene Ontology: BP: D-amino acid catabolic process, D-amino acid metabolic process, L-amino acid catabolic process, L-aspartate catabolic process, aspartate metabolic process, grooming behavior, hormone metabolic process, insemination, nervous system process, proteinogenic amino acid catabolic process, regulation of cell communication; MF: D-amino-acid oxidase activity, D-aspartate oxidase activity, D-glutamate oxidase activity, FAD binding, oxidoreductase activity, protein binding; CC: cytoplasm, cytosol, peroxisomal matrix, peroxisome
Pathways: Alanine, aspartate and glutamate metabolism - Homo sapiens (human), Aspartate Metabolism, Canavan Disease, Glyoxylate metabolism and glycine degradation, Hypoacetylaspartia, Metabolism, Metabolism of amino acids and derivatives, Peroxisomal protein import, Peroxisome - Homo sapiens (human), Protein localization
UniProt: Q99489
Entrez ID: 8528
|
Does Knockout of ABRA in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
ABRA
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: ABRA (actin binding Rho activating protein)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Predicted to be involved in positive regulation of DNA-binding transcription factor activity; positive regulation of Rho protein signal transduction; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription, DNA-templated and protein import into nucleus. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin cytoskeleton organization, positive regulation of DNA-templated transcription, positive regulation of Rho protein signal transduction, positive regulation of transcription by RNA polymerase II, protein import into nucleus, protein transport, transcription by RNA polymerase II; MF: actin binding, protein binding; CC: actin cytoskeleton, cytoplasm, cytoskeleton, myofibril, plasma membrane, sarcomere
Pathways:
UniProt: Q8N0Z2
Entrez ID: 137735
|
Does Knockout of RAN in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
RAN
|
cell proliferation
|
Cancer Cell Line
|
Gene: RAN (RAN, member RAS oncogene family)
Type: protein-coding
Summary: RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA metabolic process, GTP metabolic process, actin cytoskeleton organization, cell division, cellular response to mineralocorticoid stimulus, glycolytic process, hippocampus development, intracellular protein localization, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle organization, nucleocytoplasmic transport, positive regulation of protein import into nucleus, pre-miRNA export from nucleus, protein export from nucleus, protein import into nucleus, protein localization to nucleolus, protein transport, protein-containing complex localization, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus, ribosomal subunit export from nucleus, snRNA import into nucleus, spermatid development, viral process; MF: G protein activity, GDP binding, GTP binding, GTPase activity, RNA binding, cadherin binding, chromatin binding, dynein intermediate chain binding, hydrolase activity, importin-alpha family protein binding, magnesium ion binding, metal ion binding, nuclear export signal receptor activity, nucleotide binding, pre-miRNA binding, protein binding, protein domain specific binding, protein heterodimerization activity, protein-containing complex binding; CC: Flemming body, RNA nuclear export complex, centriole, chromatin, cytoplasm, cytosol, extracellular exosome, male germ cell nucleus, manchette, melanosome, membrane, midbody, nuclear envelope, nuclear pore, nucleolus, nucleoplasm, nucleus, protein-containing complex, recycling endosome, sperm flagellum
Pathways: 22q11.2 copy number variation syndrome, Androgen receptor signaling pathway, AndrogenReceptor, Aurora A signaling, Canonical NF-kappaB pathway, Cell Cycle, Cell Cycle, Mitotic, Disease, Export of Viral Ribonucleoproteins from Nucleus, Fibroblast growth factor-1, FoxO family signaling, Gene Silencing by RNA, Gene expression (Transcription), HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Infectious disease, Influenza Infection, Interactions of Rev with host cellular proteins, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of lipids, Metabolism of steroids, MicroRNA (miRNA) biogenesis, Mitotic Anaphase, Mitotic Metaphase and Anaphase, NEP/NS2 Interacts with the Cellular Export Machinery, Nuclear Envelope (NE) Reassembly, Nuclear import of Rev protein, Postmitotic nuclear pore complex (NPC) reformation, RNA transport - Homo sapiens (human), Regulation of cholesterol biosynthesis by SREBP (SREBF), Rev-mediated nuclear export of HIV RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Role of Calcineurin-dependent NFAT signaling in lymphocytes, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TCR, Transcriptional regulation by small RNAs, Viral Infection Pathways, cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, miRNA Biogenesis, role of ran in mitotic spindle regulation, sumoylation by ranbp2 regulates transcriptional repression, tRNA processing, tRNA processing in the nucleus
UniProt: P62826
Entrez ID: 5901
|
Does Knockout of GNL3 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
GNL3
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: GNL3 (G protein nucleolar 3)
Type: protein-coding
Summary: The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: positive regulation of miRNA transcription, positive regulation of protein localization to chromosome, telomeric region, positive regulation of protein sumoylation, positive regulation of telomere maintenance, regulation of cell population proliferation, stem cell division, stem cell population maintenance; MF: GTP binding, RNA binding, mRNA 5'-UTR binding, nucleotide binding, protein binding; CC: chromosome, extracellular space, membrane, midbody, nuclear body, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9BVP2
Entrez ID: 26354
|
Does Knockout of TMEM181 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
TMEM181
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: TMEM181 (transmembrane protein 181)
Type: protein-coding
Summary: The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010].
Gene Ontology: MF: toxic substance binding
Pathways:
UniProt: Q9P2C4
Entrez ID: 57583
|
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