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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of PRC1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
PRC1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PRC1 (protein regulator of cytokinesis 1)
Type: protein-coding
Summary: This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: cell division, microtubule cytoskeleton organization, mitotic spindle elongation, mitotic spindle midzone assembly, positive regulation of cell population proliferation, regulation of cytokinesis; MF: identical protein binding, kinesin binding, microtubule binding, protein binding, protein kinase binding; CC: chromosome, contractile ring, cytoplasm, cytoskeleton, cytosol, intercellular bridge, microtubule, microtubule cytoskeleton, midbody, mitotic spindle midzone, nucleoplasm, nucleus, plasma membrane, spindle, spindle microtubule, spindle pole
Pathways: PLK1 signaling events, RHO GTPase Effectors, RHO GTPases activate CIT, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TNFalpha
UniProt: O43663
Entrez ID: 9055
|
Does Knockout of HOXD8 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
HOXD8
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: HOXD8 (homeobox D8)
Type: protein-coding
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].
Gene Ontology: BP: anterior/posterior axis specification, embryo, anterior/posterior pattern specification, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal system morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways: IL-18 signaling pathway
UniProt: P13378
Entrez ID: 3234
|
Does Knockout of UQCRQ in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
UQCRQ
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: UQCRQ (ubiquinol-cytochrome c reductase complex III subunit VII)
Type: protein-coding
Summary: This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular respiration, cerebellar Purkinje cell layer development, hippocampus development, hypothalamus development, midbrain development, mitochondrial electron transport, ubiquinol to cytochrome c, pons development, pyramidal neuron development, subthalamus development, thalamus development; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Complex III assembly, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Metabolism of proteins, Mitochondrial complex III assembly, Mitochondrial protein degradation, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: O14949
Entrez ID: 27089
|
Does Knockout of DBN1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
DBN1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: DBN1 (drebrin 1)
Type: protein-coding
Summary: The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin filament organization, cell communication by chemical coupling, cell communication by electrical coupling, cell differentiation, generation of neurons, in utero embryonic development, maintenance of protein location in cell, nervous system development, neural precursor cell proliferation, positive regulation of dendritic spine morphogenesis, positive regulation of receptor localization to synapse, positive regulation of synaptic plasticity, regulation of dendrite development, regulation of neuronal synaptic plasticity; MF: actin binding, cadherin binding, profilin binding, protein binding, protein sequestering activity; CC: actin cytoskeleton, actomyosin, anchoring junction, cell cortex, cell periphery, cell projection, cell-cell junction, cortical cytoskeleton, cytoplasm, cytoskeleton, dendrite, gap junction, glutamatergic synapse, growth cone, membrane, neuron projection, plasma membrane, postsynaptic cytosol, postsynaptic density, postsynaptic membrane
Pathways: RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, RHOBTB2 GTPase cycle, RHOD GTPase cycle, RHOH GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q16643
Entrez ID: 1627
|
Does Knockout of ACTB in Glioma Cell Line causally result in protein/peptide accumulation?
| 1
| 589
|
Knockout
|
ACTB
|
protein/peptide accumulation
|
Glioma Cell Line
|
Gene: ACTB (actin beta)
Type: protein-coding
Summary: This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: adherens junction assembly, apical protein localization, axonogenesis, cell motility, cellular response to cytochalasin B, chromatin remodeling, cytoskeleton organization, establishment or maintenance of cell polarity, maintenance of blood-brain barrier, morphogenesis of a polarized epithelium, negative regulation of cell differentiation, platelet aggregation, positive regulation of DNA-templated transcription, positive regulation of T cell differentiation, positive regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of double-strand break repair via homologous recombination, positive regulation of myoblast differentiation, positive regulation of norepinephrine uptake, positive regulation of stem cell population maintenance, postsynaptic actin cytoskeleton organization, protein localization to adherens junction, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, regulation of mitotic metaphase/anaphase transition, regulation of norepinephrine uptake, regulation of nucleotide-excision repair, regulation of protein localization to plasma membrane, regulation of synaptic vesicle endocytosis, regulation of transcription by RNA polymerase II, regulation of transepithelial transport, substantia nigra development; MF: ATP binding, ATP hydrolysis activity, Tat protein binding, hydrolase activity, identical protein binding, kinesin binding, nitric-oxide synthase binding, nitric-oxide synthase regulator activity, nucleosomal DNA binding, nucleotide binding, protein binding, protein kinase binding, structural constituent of cytoskeleton, structural constituent of postsynaptic actin cytoskeleton, tau protein binding, transporter regulator activity; CC: GBAF complex, NuA4 histone acetyltransferase complex, RSC-type complex, SWI/SNF complex, Schaffer collateral - CA1 synapse, actin cytoskeleton, actin filament, adherens junction, apical junction complex, axon, bBAF complex, blood microparticle, brahma complex, brush border, calyx of Held, cell-cell junction, chromatin, cortical cytoskeleton, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoskeleton, cytosol, dense body, extracellular exosome, extracellular space, focal adhesion, glutamatergic synapse, kinetochore, lamellipodium, membrane, nBAF complex, npBAF complex, nuclear matrix, nucleoplasm, nucleosome, nucleus, plasma membrane, postsynaptic actin cytoskeleton, presynapse, protein-containing complex, ribonucleoprotein complex, synapse, tight junction, vesicle
Pathways: ATP-dependent chromatin remodelers, Acute viral myocarditis, Adherens junction - Homo sapiens (human), Adherens junctions interactions, Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis - Homo sapiens (human), Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Axon guidance, B-WICH complex positively regulates rRNA expression, Bacterial invasion of epithelial cells - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cell-extracellular matrix interactions, Chaperonin-mediated protein folding, Chromatin modifying enzymes, Chromatin organization, Clathrin-mediated endocytosis, Common Pathways Underlying Drug Addiction, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Developmental Biology, Dilated cardiomyopathy - Homo sapiens (human), Disease, Diseases of signal transduction by growth factor receptors and second messengers, EGFR1, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHB-mediated forward signaling, Ebola Virus Pathway on Host, Epigenetic regulation of gene expression, Extracellular matrix organization, FCGR3A-mediated phagocytosis, Factors involved in megakaryocyte development and platelet production, Fas ligand pathway and stress induction of heat shock proteins, Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion, Focal adhesion - Homo sapiens (human), Folding of actin by CCT/TriC, Formation of annular gap junctions, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the dystrophin-glycoprotein complex (DGC), Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Gastric acid secretion - Homo sapiens (human), Gene expression (Transcription), Global Genome Nucleotide Excision Repair (GG-NER), HATs acetylate histones, Hemostasis, Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Immune System, Infectious disease, Influenza A - Homo sapiens (human), Innate Immune System, Interaction between L1 and Ankyrins, L1CAM interactions, Leishmania infection, Leishmania phagocytosis, Leukocyte transendothelial migration - Homo sapiens (human), MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Membrane Trafficking, Metabolism of proteins, Myometrial relaxation and contraction pathways, Nervous system development, Neutrophil extracellular trap formation - Homo sapiens (human), Non-integrin membrane-ECM interactions, Nucleotide Excision Repair, Oncogenic MAPK signaling, Oxytocin signaling pathway - Homo sapiens (human), Paradoxical activation of RAF signaling by kinase inactive BRAF, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Phagosome - Homo sapiens (human), Platelet activation - Homo sapiens (human), Positive epigenetic regulation of rRNA expression, Post-translational protein modification, Prefoldin mediated transfer of substrate to CCT/TriC, Protein folding, Proteoglycans in cancer - Homo sapiens (human), RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases Activate WASPs and WAVEs, RHO GTPases activate IQGAPs, RHOF GTPase cycle, Rap1 signaling pathway - Homo sapiens (human), Recycling pathway of L1, Regulation of Actin Cytoskeleton, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of MITF-M-dependent genes involved in pigmentation, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Regulation of endogenous retroelements, Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs), SWI/SNF chromatin remodelers, Salmonella infection - Homo sapiens (human), Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by BRAF and RAF1 fusions, Signaling by RAF1 mutants, Signaling by RAS mutants, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Signaling by high-kinase activity BRAF mutants, Signaling by moderate kinase activity BRAF mutants, Signaling downstream of RAS mutants, The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Tight junction - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, UCH proteinases, VEGFA-VEGFR2 Pathway, Vesicle-mediated transport, Vibrio cholerae infection - Homo sapiens (human), Viral myocarditis - Homo sapiens (human), Yersinia infection - Homo sapiens (human), chromatin remodeling by hswi/snf atp-dependent complexes, the information processing pathway at the ifn beta enhancer
UniProt: P60709
Entrez ID: 60
|
Does Knockout of KLHDC10 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
KLHDC10
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: KLHDC10 (kelch domain containing 10)
Type: protein-coding
Summary: Enables ubiquitin ligase-substrate adaptor activity. Involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in nucleoplasm. Is active in Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of stress-activated MAPK cascade, protein ubiquitination, rescue of stalled ribosome, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Translation
UniProt: Q6PID8
Entrez ID: 23008
|
Does Knockout of ZFC3H1 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
ZFC3H1
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: ZFC3H1 (zinc finger C3H1-type containing)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in RNA processing. Located in nucleus. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding, zinc ion binding; CC: MTREC complex, extracellular space, nucleolus, nucleus
Pathways: Metabolism of RNA, Nuclear RNA decay
UniProt: O60293
Entrez ID: 196441
|
Does Knockout of DPH5 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
DPH5
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: DPH5 (diphthamide biosynthesis 5)
Type: protein-coding
Summary: This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: methylation, protein histidyl modification to diphthamide; MF: diphthine methyl ester synthase activity, methyltransferase activity, transferase activity; CC: cytosol
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Synthesis of diphthamide-EEF2, diphthamide biosynthesis
UniProt: Q9H2P9
Entrez ID: 51611
|
Does Knockout of BDKRB2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
BDKRB2
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: BDKRB2 (bradykinin receptor B2)
Type: protein-coding
Summary: This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, arachidonate secretion, blood circulation, cell surface receptor protein tyrosine kinase signaling pathway, cell surface receptor signaling pathway, inflammatory response, intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress, negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator, positive regulation of cytosolic calcium ion concentration, regulation of vascular permeability, regulation of vasoconstriction, response to salt stress, signal transduction, smooth muscle contraction, system process, vasoconstriction, vasodilation; MF: G protein-coupled receptor activity, bradykinin receptor activity, phosphatidylinositol-4,5-bisphosphate phospholipase C activity, protease binding, protein binding, protein heterodimerization activity, type 1 angiotensin receptor binding; CC: endosome, membrane, plasma membrane
Pathways: ACE Inhibitor Pathway, Calcium signaling pathway - Homo sapiens (human), Chagas disease - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Complement and coagulation cascades - Homo sapiens (human), Direct p53 effectors, Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Peptide GPCRs, Peptide ligand-binding receptors, RAS and bradykinin pathways in COVID-19, Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Sphingolipid signaling pathway - Homo sapiens (human), Validated transcriptional targets of deltaNp63 isoforms, actions of nitric oxide in the heart, cGMP-PKG signaling pathway - Homo sapiens (human), corticosteroids and cardioprotection, ion channels and their functional role in vascular endothelium, vegf hypoxia and angiogenesis
UniProt: P30411
Entrez ID: 624
|
Does Knockout of TBC1D3F in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
TBC1D3F
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: TBC1D3F (TBC1 domain family member 3F)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase activator activity, protein binding; CC: endosome, membrane, plasma membrane
Pathways:
UniProt: A6NER0
Entrez ID: 84218
|
Does Knockout of C3orf18 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
C3orf18
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: C3orf18 (chromosome 3 open reading frame 18)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q9UK00
Entrez ID: 51161
|
Does Activation of ABHD15 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
ABHD15
|
protein/peptide accumulation
|
T cell
|
Gene: ABHD15 (abhydrolase domain containing 15)
Type: protein-coding
Summary: Predicted to enable acylglycerol lipase activity and short-chain carboxylesterase activity. Predicted to be involved in cellular lipid metabolic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: adipose tissue development, lipid catabolic process, lipid metabolic process; MF: monoacylglycerol lipase activity, protein binding, short-chain carboxylesterase activity; CC: extracellular region, membrane
Pathways:
UniProt: Q6UXT9
Entrez ID: 116236
|
Does Knockout of EIF2B1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
EIF2B1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha)
Type: protein-coding
Summary: This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: T cell receptor signaling pathway, cytoplasmic translational initiation, oligodendrocyte development, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, identical protein binding, protein binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex, membrane, plasma membrane
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Translation, Translation Factors
UniProt: Q14232
Entrez ID: 1967
|
Does Knockout of PGAM1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
PGAM1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: PGAM1 (phosphoglycerate mutase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: canonical glycolysis, gluconeogenesis, glycolytic process; MF: bisphosphoglycerate mutase activity, catalytic activity, hydrolase activity, intramolecular phosphotransferase activity, isomerase activity, phosphoglycerate mutase activity, protein binding, protein kinase binding; CC: cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, secretory granule lumen
Pathways: Central carbon metabolism in cancer - Homo sapiens (human), Cori Cycle, EGFR1, Fanconi-bickel syndrome, Fructose-1,6-diphosphatase deficiency, Glucagon signaling pathway - Homo sapiens (human), Gluconeogenesis, Glucose metabolism, Glycine, serine and threonine metabolism - Homo sapiens (human), Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycogenosis, Type VII. Tarui disease, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, Immune System, Innate Immune System, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Rapoport-Luebering glycolytic shunt, TCR, Triosephosphate isomerase, gluconeogenesis, glycolysis, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P18669
Entrez ID: 5223
|
Does Knockout of OTOP1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
OTOP1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: OTOP1 (otopetrin 1)
Type: protein-coding
Summary: This gene encodes a transmembrane protein which belongs to the otopetrin domain protein family and is required for the formation of otoconia and otoliths, calcium carbonate biominerals within the inner ear of mammals that are required for the detection of linear acceleration and gravity. This gene modulates purinergic control of intracellular calcium in vestibular supporting cells. Naturally occurring mutations in the orthologous mouse gene are associated with nonsyndromic otoconia agenesis and a consequent balance defect. The orthologous mouse gene is also induced in white adipose tissue during obesity. The encoded protein is a component of a counterinflammatory pathway that attenuates obesity-induced adipose tissue inflammation and plays an adaptive role in maintaining metabolic homeostasis in obesity. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: biomineral tissue development, cellular response to insulin stimulus, detection of gravity, inner ear morphogenesis, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of type II interferon-mediated signaling pathway, otolith formation, otolith mineralization, proton transmembrane transport; MF: identical protein binding, proton channel activity; CC: cell projection, membrane, microvillus, plasma membrane
Pathways: Sensory Perception, Sensory perception of sour taste, Sensory perception of taste
UniProt: Q7RTM1
Entrez ID: 133060
|
Does Knockout of TRIM28 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
TRIM28
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TRIM28 (tripartite motif containing 28)
Type: protein-coding
Summary: The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, DNA repair, chromatin organization, convergent extension involved in axis elongation, embryo implantation, embryonic placenta morphogenesis, epigenetic programming of gene expression, epithelial to mesenchymal transition, genomic imprinting, in utero embryonic development, innate immune response, negative regulation of DNA-templated transcription, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of macromolecule metabolic process, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein import into nucleus, proteasome-mediated ubiquitin-dependent protein catabolic process, protein sumoylation, suppression of viral release by host; MF: DNA binding, Krueppel-associated box domain binding, RNA binding, SUMO transferase activity, chromatin binding, chromo shadow domain binding, metal ion binding, promoter-specific chromatin binding, protein binding, protein kinase activity, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-like protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: RNA polymerase II transcription regulator complex, chromatin, euchromatin, heterochromatin, nucleoplasm, nucleus, protein-containing complex
Pathways: ATM Signaling Network in Development and Disease, ATM pathway, C-MYB transcription factor network, Corticotropin-releasing hormone signaling pathway, Disease, E2F transcription factor network, Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, HCMV Early Events, HCMV Infection, Infectious disease, Mesodermal commitment pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins, Regulatory circuits of the STAT3 signaling pathway, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Viral Infection Pathways, p53 pathway
UniProt: Q13263
Entrez ID: 10155
|
Does Knockout of NUF2 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
NUF2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: NUF2 (NUF2 component of NDC80 kinetochore complex)
Type: protein-coding
Summary: This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore organization, meiotic chromosome segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization; MF: microtubule binding, protein binding, protein-containing complex binding; CC: Ndc80 complex, chromosome, chromosome, centromeric region, cytosol, kinetochore, membrane, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9BZD4
Entrez ID: 83540
|
Does Knockout of PAK1IP1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
PAK1IP1
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: PAK1IP1 (PAK1 interacting protein 1)
Type: protein-coding
Summary: Involved in regulation of signal transduction by p53 class mediator and ribosomal large subunit biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell population proliferation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of signal transduction, regulation of signal transduction by p53 class mediator, ribosomal large subunit biogenesis, ribosome biogenesis, roof of mouth development; MF: protein binding, protein kinase inhibitor activity; CC: nucleolus, nucleus
Pathways:
UniProt: Q9NWT1
Entrez ID: 55003
|
Does Knockout of HOXD1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
HOXD1
|
cell proliferation
|
Cancer Cell Line
|
Gene: HOXD1 (homeobox D1)
Type: protein-coding
Summary: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: embryonic skeletal system development, neuron differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, sensory perception of pain; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Developmental Biology, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
UniProt: Q9GZZ0
Entrez ID: 3231
|
Does Knockout of TCFL5 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
TCFL5
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: TCFL5 (transcription factor like 5)
Type: protein-coding
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell population proliferation; and spermatogenesis. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell differentiation, regulation of cell population proliferation, spermatogenesis, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: chromatin, male germ cell nucleus, nucleus
Pathways:
UniProt: Q9UL49
Entrez ID: 10732
|
Does Knockout of KRT82 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
KRT82
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: KRT82 (keratin 82)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this keratin appears to be a hair cuticle-specific keratin. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: intermediate filament organization, keratinization; MF: protein binding, structural constituent of skin epidermis; CC: cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q9NSB4
Entrez ID: 3888
|
Does Knockout of TRAPPC3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
TRAPPC3
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: TRAPPC3 (trafficking protein particle complex subunit 3)
Type: protein-coding
Summary: This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: COPII vesicle coating, Golgi vesicle transport, endoplasmic reticulum to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, Golgi membrane, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, cis-Golgi network membrane, cytoplasm, cytosol, endoplasmic reticulum
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O43617
Entrez ID: 27095
|
Does Knockout of NFYC in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
NFYC
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: NFYC (nuclear transcription factor Y subunit gamma)
Type: protein-coding
Summary: This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
Gene Ontology: BP: positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, protein folding, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, protein heterodimerization activity, transcription cis-regulatory region binding; CC: CCAAT-binding factor complex, RNA polymerase II transcription regulator complex, chromatin, nucleoplasm, nucleus, protein-DNA complex, transcription regulator complex
Pathways: Antigen processing and presentation - Homo sapiens (human), Direct p53 effectors, TGF_beta_Receptor, Tuberculosis - Homo sapiens (human), Validated targets of C-MYC transcriptional repression, overview of telomerase rna component gene hterc transcriptional regulation
UniProt: Q13952
Entrez ID: 4802
|
Does Knockout of DPPA3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
DPPA3
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: DPPA3 (developmental pluripotency associated 3)
Type: protein-coding
Summary: This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin organization, epigenetic programing of female pronucleus; MF: histone H3K9me2/3 reader activity, protein binding; CC: cytoplasm, female pronucleus, male pronucleus, nucleus
Pathways: Chromatin modifications during the maternal to zygotic transition (MZT), Developmental Biology, Maternal to zygotic transition (MZT), Pre-implantation embryo
UniProt: Q6W0C5
Entrez ID: 359787
|
Does Knockout of DNAJC14 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
DNAJC14
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: DNAJC14 (DnaJ heat shock protein family (Hsp40) member C14)
Type: protein-coding
Summary: Predicted to be involved in protein transport. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: G protein-coupled receptor binding, dopamine receptor binding, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q6Y2X3
Entrez ID: 85406
|
Does Inhibition of MED16 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
MED16
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MED16 (mediator complex subunit 16)
Type: protein-coding
Summary: Enables thyroid hormone receptor binding activity and transcription coactivator activity. Involved in positive regulation of transcription initiation from RNA polymerase II promoter. Located in membrane. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, protein binding, transcription coactivator activity; CC: core mediator complex, mediator complex, membrane, nucleoplasm, nucleus
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Thyroid hormone signaling pathway - Homo sapiens (human), Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9Y2X0
Entrez ID: 10025
|
Does Knockout of SLFN12 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
SLFN12
|
cell proliferation
|
T-lymphoma cell line
|
Gene: SLFN12 (schlafen family member 12)
Type: protein-coding
Summary: Predicted to act upstream of or within negative regulation of cell population proliferation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic signaling pathway, rRNA catabolic process; MF: RNA nuclease activity, hydrolase activity, protein binding, ribosome binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8IYM2
Entrez ID: 55106
|
Does Knockout of SERINC2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
SERINC2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SERINC2 (serine incorporator 2)
Type: protein-coding
Summary: Predicted to be involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: phosphatidylserine metabolic process, plasma membrane phospholipid scrambling; MF: acetyltransferase activator activity, phospholipid scramblase activity; CC: extracellular exosome, membrane, plasma membrane
Pathways: Metabolism, Metabolism of amino acids and derivatives, Serine metabolism
UniProt: Q96SA4
Entrez ID: 347735
|
Does Knockout of NF2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
NF2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor)
Type: protein-coding
Summary: This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. [provided by RefSeq, May 2022].
Gene Ontology: BP: MAPK cascade, Schwann cell proliferation, actin cytoskeleton organization, brain development, cell differentiation, cell-cell junction organization, ectoderm development, hippocampus development, lens fiber cell differentiation, mesoderm formation, negative regulation of MAPK cascade, negative regulation of Schwann cell proliferation, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of cell-cell adhesion, negative regulation of cell-matrix adhesion, negative regulation of osteoblast proliferation, negative regulation of receptor signaling pathway via JAK-STAT, odontogenesis of dentin-containing tooth, osteoblast proliferation, positive regulation of cell differentiation, positive regulation of early endosome to late endosome transport, positive regulation of protein localization to early endosome, positive regulation of stress fiber assembly, regulation of apoptotic process, regulation of cell cycle, regulation of cell population proliferation, regulation of cell shape, regulation of gliogenesis, regulation of hippo signaling, regulation of neural precursor cell proliferation, regulation of neurogenesis, regulation of organelle assembly, regulation of protein localization to nucleus, regulation of protein stability, regulation of stem cell proliferation; MF: actin binding, cytoskeletal protein binding, integrin binding, protein binding; CC: adherens junction, apical part of cell, cell body, cell projection, cleavage furrow, cortical actin cytoskeleton, cytoplasm, cytoskeleton, cytosol, early endosome, filopodium, filopodium membrane, lamellipodium, membrane, neuron projection, nucleolus, nucleus, perinuclear region of cytoplasm, plasma membrane, ruffle, ruffle membrane
Pathways: 3q29 copy number variation syndrome, Ectoderm Differentiation, ErbB2/ErbB3 signaling events, Hippo signaling pathway - Homo sapiens (human), Hippo signaling pathway - multiple species - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Hippo-Yap signaling pathway, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Pathways Regulating Hippo Signaling, Tight junction - Homo sapiens (human)
UniProt: P35240
Entrez ID: 4771
|
Does Knockout of LDLRAD2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
LDLRAD2
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: LDLRAD2 (low density lipoprotein receptor class A domain containing 2)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q5SZI1
Entrez ID: 401944
|
Does Knockout of GREM2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
GREM2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: GREM2 (gremlin 2, DAN family BMP antagonist)
Type: protein-coding
Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytokine-mediated signaling pathway, determination of dorsal identity, embryonic body morphogenesis, negative regulation of BMP signaling pathway, regulation of cytokine activity, sequestering of BMP from receptor via BMP binding; MF: BMP binding, cytokine activity, heparin binding, identical protein binding, receptor ligand activity; CC: extracellular region, extracellular space
Pathways: BMP Signalling Pathway, Signal Transduction, Signaling by BMP, Signaling by TGFB family members, TGF-beta signaling pathway - Homo sapiens (human)
UniProt: Q9H772
Entrez ID: 64388
|
Does Knockout of PSMD6 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
PSMD6
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: PSMD6 (proteasome 26S subunit, non-ATPase 6)
Type: protein-coding
Summary: This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process; CC: cytosol, extracellular region, ficolin-1-rich granule lumen, nucleoplasm, proteasome accessory complex, proteasome complex, proteasome regulatory particle, protein-containing complex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q15008
Entrez ID: 9861
|
Does Knockout of TAPT1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
TAPT1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: TAPT1 (transmembrane anterior posterior transformation 1)
Type: protein-coding
Summary: This gene encodes a highly conserved protein that localizes to the centrosome and/or ciliary basal body. Mutations in this gene disrupt Golgi morphology and trafficking and normal primary cilium formation and these mutations are congenitally manifested by severe undermineralization of the intra-uterine skeleton. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. In mouse, this gene is thought to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cartilage development, cell differentiation, cell projection organization, embryonic skeletal system development, neural crest cell development, ossification, positive regulation of bone development, positive regulation of cartilage development, positive regulation of cilium assembly; CC: cell projection, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum membrane, membrane, nucleoplasm
Pathways: Ciliopathies
UniProt: Q6NXT6
Entrez ID: 202018
|
Does Knockout of GNL2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
GNL2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: GNL2 (G protein nucleolar 2)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in ribosome biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTP binding, GTPase activity, RNA binding, nucleotide binding; CC: membrane, nucleolus, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q13823
Entrez ID: 29889
|
Does Knockout of DCXR in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
DCXR
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: DCXR (dicarbonyl and L-xylulose reductase)
Type: protein-coding
Summary: The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010].
Gene Ontology: BP: D-glucuronate catabolic process to D-xylulose 5-phosphate, D-xylose metabolic process, NADP+ metabolic process, glucose metabolic process, positive regulation of reactive oxygen species metabolic process, xylulose metabolic process; MF: L-xylulose reductase (NADPH) activity, carbonyl reductase (NADPH) activity, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors, oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, protein binding; CC: brush border, cytoplasmic microtubule, cytosol, extracellular exosome, membrane, microvillus, mitochondrion, nucleus, plasma membrane
Pathways: D-glucuronate degradation, Disease, Diseases of carbohydrate metabolism, Diseases of metabolism, Essential pentosuria, Formation of xylulose-5-phosphate, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose and glucuronate interconversions - Homo sapiens (human)
UniProt: Q7Z4W1
Entrez ID: 51181
|
Does Knockout of MFSD6L in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
MFSD6L
|
response to chemicals
|
Melanoma Cell Line
|
Gene: MFSD6L (major facilitator superfamily domain containing 6 like)
Type: protein-coding
Summary: Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane
Pathways:
UniProt: Q8IWD5
Entrez ID: 162387
|
Does Knockout of CXCL17 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
CXCL17
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: CXCL17 (C-X-C motif chemokine ligand 17)
Type: protein-coding
Summary: The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: angiogenesis, cell differentiation, chemotaxis, macrophage chemotaxis, negative regulation of inflammatory response, positive regulation of ERK1 and ERK2 cascade, positive regulation of macrophage chemotaxis, positive regulation of monocyte chemotaxis, positive regulation of vascular endothelial growth factor production; CC: extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human), SARS-CoV-2 innate immunity evasion and cell-specific immune response
UniProt: Q6UXB2
Entrez ID: 284340
|
Does Knockout of PLA2G6 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
PLA2G6
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: PLA2G6 (phospholipase A2 group VI)
Type: protein-coding
Summary: The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: Fc-gamma receptor signaling pathway involved in phagocytosis, antibacterial humoral response, cardiolipin acyl-chain remodeling, chemotaxis, lipid metabolic process, phosphatidic acid metabolic process, phosphatidylcholine catabolic process, phosphatidylethanolamine catabolic process, platelet activating factor metabolic process, positive regulation of ceramide biosynthetic process, positive regulation of insulin secretion involved in cellular response to glucose stimulus; MF: 1-alkyl-2-acetylglycerophosphocholine esterase activity, calcium-independent phospholipase A2 activity, calmodulin binding, hydrolase activity, identical protein binding, long-chain fatty acyl-CoA hydrolase activity, phosphatidylcholine lysophospholipase activity, phospholipase A2 activity, protein binding, serine hydrolase activity; CC: cell projection, cytoplasm, cytosol, extracellular space, membrane, microtubule cytoskeleton, mitochondrion, nuclear speck, plasma membrane, pseudopodium
Pathways: Acyl chain remodeling of CL, Acyl chain remodelling of PC, Acyl chain remodelling of PE, Arachidonic acid metabolism - Homo sapiens (human), COPI-independent Golgi-to-ER retrograde traffic, Eicosanoid Synthesis, Eicosanoid metabolism via cyclooxygenases (COX), Ether lipid metabolism - Homo sapiens (human), Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Golgi-to-ER retrograde transport, Immune System, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Linoleic acid metabolism - Homo sapiens (human), Membrane Trafficking, Metabolism, Metabolism of lipids, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Omega-3-Omega-6 FA synthesis, Phospholipid metabolism, Ras signaling, Ras signaling pathway - Homo sapiens (human), Role of phospholipids in phagocytosis, Spinal Cord Injury, Vascular smooth muscle contraction - Homo sapiens (human), Vesicle-mediated transport, alpha-Linolenic acid metabolism - Homo sapiens (human), phospholipases
UniProt: O60733
Entrez ID: 8398
|
Does Knockout of VIRMA in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
VIRMA
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: VIRMA (vir like m6A methyltransferase associated)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA alternative polyadenylation and mRNA methylation. Located in cytosol and nuclear speck. Colocalizes with RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing; MF: RNA binding, protein binding; CC: RNA N6-methyladenosine methyltransferase complex, cytoplasm, cytosol, nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q69YN4
Entrez ID: 25962
|
Does Knockout of NUP133 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
NUP133
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: NUP133 (nucleoporin 133)
Type: protein-coding
Summary: The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: animal organ development, mRNA export from nucleus, mRNA transport, nephron development, neural tube development, neurogenesis, nuclear pore organization, nucleocytoplasmic transport, paraxial mesoderm development, poly(A)+ mRNA export from nucleus, protein import into nucleus, protein transport, somite development, system development, transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; MF: protein binding, structural constituent of nuclear pore; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore outer ring, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, EML4 and NUDC in mitotic spindle formation, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q8WUM0
Entrez ID: 55746
|
Does Knockout of RTN4IP1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
RTN4IP1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RTN4IP1 (reticulon 4 interacting protein 1)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, cognitive disability, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: nervous system development, regulation of dendrite development, ubiquinone biosynthetic process; MF: NADPH dehydrogenase (quinone) activity, nucleotide binding, oxidoreductase activity, protein binding, zinc ion binding; CC: membrane, mitochondrial matrix, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q8WWV3
Entrez ID: 84816
|
Does Knockout of SH3BP1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
SH3BP1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: SH3BP1 (SH3 domain binding protein 1)
Type: protein-coding
Summary: This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: actin filament organization, cell junction assembly, cell migration, establishment of epithelial cell apical/basal polarity, negative regulation of small GTPase mediated signal transduction, phagocytosis, phagocytosis, engulfment, positive regulation of GTPase activity, regulation of Rac protein signal transduction, regulation of actin cytoskeleton organization, regulation of actin filament depolymerization, regulation of blood vessel endothelial cell migration, regulation of small GTPase mediated signal transduction, ruffle assembly, semaphorin-plexin signaling pathway, signal transduction; MF: GTPase activator activity, SH3 domain binding, protein binding, semaphorin receptor binding; CC: adherens junction, anchoring junction, bicellular tight junction, cell leading edge, cell projection, cytoplasm, cytosol, exocyst, lamellipodium, nucleus, phagocytic cup, plasma membrane
Pathways: RAC1 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9Y3L3
Entrez ID: 23616
|
Does Knockout of TMEM86B in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
TMEM86B
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: TMEM86B (transmembrane protein 86B)
Type: protein-coding
Summary: Enables alkenylglycerophosphocholine hydrolase activity; alkenylglycerophosphoethanolamine hydrolase activity; and identical protein binding activity. Involved in ether lipid metabolic process. Located in cytoplasm and membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ether lipid metabolic process, lipid metabolic process, phosphatidylcholine acyl-chain remodeling; MF: D-lysine 5,6-aminomutase activity, alkenylglycerophosphocholine hydrolase activity, ether hydrolase activity, hydrolase activity, identical protein binding, protein binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Acyl chain remodelling of PC, Ether lipid metabolism - Homo sapiens (human), Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism
UniProt: Q8N661
Entrez ID: 255043
|
Does Activation of TRNP1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
TRNP1
|
response to virus
|
Hepatoma Cell Line
|
Gene: TRNP1 (TMF1 regulated nuclear protein 1)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be involved in several processes, including cerebellar cortex morphogenesis; neural precursor cell proliferation; and regulation of cell population proliferation. Predicted to be active in nucleus. Predicted to colocalize with euchromatin. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cerebellar cortex morphogenesis, nervous system development, neural precursor cell proliferation, regulation of cell cycle, regulation of cell population proliferation; MF: DNA binding; CC: euchromatin, nucleus
Pathways:
UniProt: Q6NT89
Entrez ID: 388610
|
Does Knockout of PHYHIPL in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
PHYHIPL
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: PHYHIPL (phytanoyl-CoA 2-hydroxylase interacting protein like)
Type: protein-coding
Summary: Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm
Pathways:
UniProt: Q96FC7
Entrez ID: 84457
|
Does Knockout of PRELID1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
PRELID1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PRELID1 (PRELI domain containing 1)
Type: protein-coding
Summary: This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: apoptotic process, intermembrane lipid transfer, lipid transport, negative regulation of apoptotic process, negative regulation of mitochondrial membrane potential, negative regulation of release of cytochrome c from mitochondria, phospholipid transport, positive regulation of T cell apoptotic process, positive regulation of cellular respiration, positive regulation of endopeptidase activity, positive regulation of phospholipid transport, regulation of T cell differentiation, regulation of membrane lipid distribution, regulation of mitochondrial membrane potential; MF: phosphatidic acid transfer activity, protein binding; CC: mitochondrial intermembrane space, mitochondrion, nucleoplasm, protein-containing complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Mitochondrial protein degradation, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53
UniProt: Q9Y255
Entrez ID: 27166
|
Does Knockout of UBQLN3 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
UBQLN3
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: UBQLN3 (ubiquilin 3)
Type: protein-coding
Summary: This gene encodes a ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis. It has been suggested that this gene may regulate cell-cycle progression during spermatogenesis, however, it has been shown that the ortholgous mouse gene is dispensable for embryonic development and spermatogenesis. [provided by RefSeq, Nov 2016].
Gene Ontology: BP: cellular response to stress, regulation of proteasomal protein catabolic process, ubiquitin-dependent protein catabolic process; MF: polyubiquitin modification-dependent protein binding, protein binding
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human)
UniProt: Q9H347
Entrez ID: 50613
|
Does Knockout of DHRS12 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
DHRS12
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: DHRS12 (dehydrogenase/reductase 12)
Type: protein-coding
Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012].
Gene Ontology:
Pathways:
UniProt: A0PJE2
Entrez ID: 79758
|
Does Knockout of NUCB1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
NUCB1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NUCB1 (nucleobindin 1)
Type: protein-coding
Summary: This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010].
Gene Ontology: MF: DNA binding, G-protein alpha-subunit binding, calcium ion binding, guanyl-nucleotide exchange factor activity, metal ion binding, protein binding; CC: Golgi apparatus, cytoplasm, endomembrane system, endoplasmic reticulum lumen, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, extracellular region, extracellular space, membrane
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q02818
Entrez ID: 4924
|
Does Knockout of C21orf58 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
C21orf58
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: C21orf58 (chromosome 21 open reading frame 58)
Type: protein-coding
Summary: chromosome 21 open reading frame 58
Gene Ontology:
Pathways:
UniProt: P58505
Entrez ID: 54058
|
Does Knockout of HUWE1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
HUWE1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1)
Type: protein-coding
Summary: This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: DNA damage response, DNA repair, Golgi organization, base-excision repair, canonical NF-kappaB signal transduction, cell differentiation, chromatin remodeling, circadian regulation of gene expression, defense response to bacterium, membrane fusion, negative regulation of canonical NF-kappaB signal transduction, negative regulation of mitochondrial fusion, negative regulation of peroxisome proliferator activated receptor signaling pathway, peroxisome proliferator activated receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of protein targeting to mitochondrion, positive regulation of protein ubiquitination, positive regulation of type 2 mitophagy, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein branched polyubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, rhythmic process, ubiquitin-dependent protein catabolic process; MF: DNA binding, RNA binding, histone ubiquitin ligase activity, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity; CC: Golgi membrane, cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, mitochondrion, nucleoplasm, nucleus, secretory granule lumen
Pathways: EGFR1, Ubiquitin mediated proteolysis - Homo sapiens (human), Validated targets of C-MYC transcriptional activation, p53 pathway
UniProt: Q7Z6Z7
Entrez ID: 10075
|
Does Knockout of CENPW in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
CENPW
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CENPW (centromere protein W)
Type: protein-coding
Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Involved in chromosome segregation; kinetochore assembly; and mitotic cell cycle. Located in kinetochore and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CENP-A containing chromatin assembly, cell division, chromosome organization, chromosome segregation, kinetochore assembly, mitotic cell cycle; MF: DNA binding, protein binding, protein heterodimerization activity; CC: chromosome, chromosome, centromeric region, inner kinetochore, kinetochore, nuclear matrix, nucleolus, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, Nucleosome assembly
UniProt: Q5EE01
Entrez ID: 387103
|
Does Knockout of CEBPZ in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
CEBPZ
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CEBPZ (CCAAT enhancer binding protein zeta)
Type: protein-coding
Summary: This gene belongs to the CBF/Mak21 family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. [provided by RefSeq, Nov 2020].
Gene Ontology: MF: DNA binding, RNA binding, protein binding, transcription coactivator activity; CC: CCAAT-binding factor complex, nucleoplasm, nucleus
Pathways: Direct p53 effectors, Gastric Cancer Network 2
UniProt: Q03701
Entrez ID: 10153
|
Does Knockout of RHOBTB1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
RHOBTB1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: RHOBTB1 (Rho related BTB domain containing 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].
Gene Ontology: BP: actin filament organization, cortical cytoskeleton organization, establishment or maintenance of cell polarity, regulation of actin cytoskeleton organization, regulation of cell shape, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding; CC: cell projection, cytoplasmic vesicle, cytoskeleton, endosome membrane, plasma membrane
Pathways: RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: O94844
Entrez ID: 9886
|
Does Knockout of MON1A in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
MON1A
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: MON1A (MON1 vesicular trafficking associated A)
Type: protein-coding
Summary: Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in protein secretion. Predicted to act upstream of or within cellular iron ion homeostasis and protein transport. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein secretion, protein targeting to vacuole, vesicle-mediated transport; MF: guanyl-nucleotide exchange factor activity, protein binding; CC: Mon1-Ccz1 complex, cytosol
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q86VX9
Entrez ID: 84315
|
Does Knockout of VDAC3 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
VDAC3
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: VDAC3 (voltage dependent anion channel 3)
Type: protein-coding
Summary: This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: adenine transport, behavioral fear response, chemical synaptic transmission, learning, monoatomic anion transmembrane transport, monoatomic ion transport, neuron-neuron synaptic transmission, sperm mitochondrial sheath assembly, spermatogenesis, transmembrane transport; MF: nucleotide binding, porin activity, protein binding, voltage-gated monoatomic anion channel activity, voltage-gated monoatomic ion channel activity; CC: extracellular exosome, membrane, mitochondrial outer membrane, mitochondrion, nucleus, pore complex, synapse
Pathways: Alzheimer disease - Homo sapiens (human), Autophagy, Calcium signaling pathway - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Cholesterol metabolism - Homo sapiens (human), Deubiquitination, Diabetic cardiomyopathy - Homo sapiens (human), Ferroptosis, Ferroptosis - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), Macroautophagy, Metabolism of proteins, Mitochondrial calcium ion transport, Mitophagy, NOD-like receptor signaling pathway - Homo sapiens (human), Necroptosis - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), PINK1-PRKN Mediated Mitophagy, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Selective autophagy, Spinocerebellar ataxia - Homo sapiens (human), Transport of small molecules, Ub-specific processing proteases, Viral carcinogenesis - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: Q9Y277
Entrez ID: 7419
|
Does Knockout of APH1A in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
APH1A
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: APH1A (aph-1A gamma-secretase subunit)
Type: protein-coding
Summary: This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: Notch receptor processing, Notch signaling pathway, amyloid precursor protein catabolic process, amyloid precursor protein metabolic process, amyloid-beta formation, membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, metanephros development, protein processing, proteolysis; MF: endopeptidase activator activity, enzyme binding, protein binding, protein-macromolecule adaptor activity; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, early endosome, endoplasmic reticulum, endoplasmic reticulum membrane, endosome membrane, gamma-secretase complex, membrane, plasma membrane, presynaptic membrane, synaptic membrane, synaptic vesicle
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amyloid fiber formation, Axon guidance, Cell death signalling via NRAGE, NRIF and NADE, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Death Receptor Signaling, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, Metabolism of proteins, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, NOTCH4 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Nervous system development, Noncanonical activation of NOTCH3, Notch, Notch Signaling, Notch Signaling Pathway Netpath, Notch signaling pathway, Notch signaling pathway - Homo sapiens (human), Nuclear signaling by ERBB4, Presenilin action in Notch and Wnt signaling, Regulated proteolysis of p75NTR, Signal Transduction, Signaling by ERBB4, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by NOTCH4, Signaling by Receptor Tyrosine Kinases, Signaling by TGFB family members, Signaling by TGFBR3, Syndecan-3-mediated signaling events, TGFBR3 PTM regulation, p75 NTR receptor-mediated signalling, p75(NTR)-mediated signaling
UniProt: Q96BI3
Entrez ID: 51107
|
Does Knockout of PRPH in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
PRPH
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PRPH (peripherin)
Type: protein-coding
Summary: This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: protein binding, structural constituent of cytoskeleton, structural molecule activity; CC: axon, cell projection, cytoplasm, cytoskeleton, extracellular exosome, intermediate filament, membrane, perikaryon, plasma membrane, type III intermediate filament
Pathways: Amyotrophic lateral sclerosis (ALS), Amyotrophic lateral sclerosis - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
UniProt: P41219
Entrez ID: 5630
|
Does Knockout of TMEM41B in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
TMEM41B
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: TMEM41B (transmembrane protein 41B)
Type: protein-coding
Summary: Involved in autophagosome assembly. Located in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagosome assembly, autophagy, host-mediated perturbation of viral RNA genome replication, intracellular lipid transport, lipid transport, nervous system development, plasma membrane phospholipid scrambling; MF: phospholipid scramblase activity, protein binding; CC: cytoplasm, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondria-associated endoplasmic reticulum membrane contact site
Pathways:
UniProt: Q5BJD5
Entrez ID: 440026
|
Does Knockout of COX15 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
COX15
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: COX15 (cytochrome c oxidase assembly factor COX15)
Type: protein-coding
Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytochrome complex assembly, heme A biosynthetic process, heme biosynthetic process; MF: heme A synthase activity, heme binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor, oxidoreductase activity, acting on the CH-CH group of donors, protein binding; CC: cytochrome complex, membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm, respiratory chain complex
Pathways: Acute Intermittent Porphyria, Aerobic respiration and respiratory electron transport, Complex IV assembly, Congenital Erythropoietic Porphyria (CEP) or Gunther Disease, Electron Transport Chain (OXPHOS system in mitochondria), Heme biosynthesis, Hereditary Coproporphyria (HCP), Metabolism, Metabolism of porphyrins, Mitochondrial CIV Assembly, Oxidative phosphorylation - Homo sapiens (human), Porphyria Variegata (PV), Porphyrin Metabolism, Porphyrin and chlorophyll metabolism - Homo sapiens (human), Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: Q7KZN9
Entrez ID: 1355
|
Does Knockout of UPF2 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
UPF2
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: UPF2 (UPF2 regulator of nonsense mediated mRNA decay)
Type: protein-coding
Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: animal organ regeneration, liver development, mRNA export from nucleus, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; MF: RNA binding, protein binding, telomeric DNA binding; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, exon-exon junction complex, nucleus, perinuclear region of cytoplasm
Pathways: Axon guidance, Developmental Biology, Metabolism of RNA, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), RNA transport - Homo sapiens (human), Regulation of expression of SLITs and ROBOs, Signaling by ROBO receptors, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9HAU5
Entrez ID: 26019
|
Does Knockout of MANSC1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
MANSC1
|
cell proliferation
|
Cancer Cell Line
|
Gene: MANSC1 (MANSC domain containing 1)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Golgi apparatus, membrane
Pathways:
UniProt: Q9H8J5
Entrez ID: 54682
|
Does Knockout of MT1A in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
MT1A
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: MT1A (metallothionein 1A)
Type: protein-coding
Summary: This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017].
Gene Ontology: BP: cellular response to cadmium ion, cellular response to copper ion, cellular response to zinc ion, detoxification of copper ion, intracellular zinc ion homeostasis, negative regulation of growth; MF: metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol, nucleus
Pathways: Cellular responses to stimuli, Copper homeostasis, Metallothioneins bind metals, Mineral absorption - Homo sapiens (human), Response to metal ions, Zinc homeostasis
UniProt: P04731
Entrez ID: 4489
|
Does Activation of ITGA8 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
ITGA8
|
response to virus
|
Hepatoma Cell Line
|
Gene: ITGA8 (integrin subunit alpha 8)
Type: protein-coding
Summary: Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: cell adhesion, cell differentiation, cell projection organization, cell-cell adhesion, cell-matrix adhesion, cell-substrate adhesion, establishment of protein localization, extracellular matrix organization, formation of primary germ layer, inner ear morphogenesis, integrin-mediated signaling pathway, kidney development, memory, mesodermal cell differentiation, metanephros development, nervous system development, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, smooth muscle cell differentiation, smooth muscle tissue development, substrate adhesion-dependent cell spreading, tissue development, transforming growth factor beta receptor signaling pathway; MF: metal ion binding, signaling receptor activity; CC: apical part of cell, cell surface, dendritic spine membrane, endoplasmic reticulum, focal adhesion, glutamatergic synapse, integrin alpha8-beta1 complex, integrin complex, membrane, perikaryon, plasma membrane, postsynaptic density membrane
Pathways: Arf6 trafficking events, Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Beta1 integrin cell surface interactions, Cell adhesion molecules - Homo sapiens (human), Development of ureteric collection system, Developmental Biology, Dilated cardiomyopathy - Homo sapiens (human), ECM proteoglycans, ECM-receptor interaction - Homo sapiens (human), Elastic fibre formation, Extracellular matrix organization, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Formation of the ureteric bud, Genes controlling nephrogenesis, Hippo-Merlin Signaling Dysregulation, Human papillomavirus infection - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Integrin cell surface interactions, Integrin-mediated Cell Adhesion, Kidney development, Molecules associated with elastic fibres, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Plexin-D1 Signaling, Regulation of actin cytoskeleton - Homo sapiens (human), Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs
UniProt: P53708
Entrez ID: 8516
|
Does Knockout of ADAM33 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
ADAM33
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ADAM33 (ADAM metallopeptidase domain 33)
Type: protein-coding
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: proteolysis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein binding, zinc ion binding; CC: membrane
Pathways:
UniProt: Q9BZ11
Entrez ID: 80332
|
Does Knockout of SRM in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
SRM
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: SRM (spermidine synthase)
Type: protein-coding
Summary: The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, polyamine biosynthetic process, polyamine metabolic process, spermidine biosynthetic process; MF: catalytic activity, identical protein binding, protein binding, protein homodimerization activity, spermidine synthase activity, transferase activity; CC: cytosol
Pathways: Amino Acid metabolism, Arginine and proline metabolism - Homo sapiens (human), Cystathionine Beta-Synthase Deficiency, Cysteine and methionine metabolism - Homo sapiens (human), Glutathione metabolism - Homo sapiens (human), Glycine N-methyltransferase Deficiency, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, Metabolism, Metabolism of amino acids and derivatives, Metabolism of polyamines, Methionine Adenosyltransferase Deficiency, Methionine De Novo and Salvage Pathway, Methionine Metabolism, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), Nucleotide metabolism, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, Spermidine and Spermine Biosynthesis, spermidine biosynthesis
UniProt: P19623
Entrez ID: 6723
|
Does Knockout of ATP7A in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
ATP7A
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: ATP7A (ATPase copper transporting alpha)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: ATP metabolic process, L-tryptophan metabolic process, T-helper cell differentiation, blood vessel development, blood vessel remodeling, cartilage development, catecholamine metabolic process, central nervous system neuron development, cerebellar Purkinje cell differentiation, collagen fibril organization, copper ion export, copper ion import, copper ion transport, dendrite morphogenesis, detoxification of copper ion, dopamine metabolic process, elastic fiber assembly, epinephrine metabolic process, establishment of localization in cell, extracellular matrix organization, glycoprotein biosynthetic process, hair follicle morphogenesis, intracellular copper ion homeostasis, locomotory behavior, lung alveolus development, mitochondrion organization, monoatomic cation transport, monoatomic ion transport, negative regulation of catecholamine metabolic process, negative regulation of neuron apoptotic process, neuron apoptotic process, neuron cellular homeostasis, neuron projection morphogenesis, norepinephrine biosynthetic process, norepinephrine metabolic process, pigmentation, positive regulation of melanin biosynthetic process, pyramidal neuron development, regulation of gene expression, regulation of oxidative phosphorylation, release of cytochrome c from mitochondria, removal of superoxide radicals, serotonin metabolic process, skin development, tyrosine metabolic process; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled monoatomic cation transmembrane transporter activity, P-type divalent copper transporter activity, P-type ion transporter activity, P-type monovalent copper transporter activity, copper ion binding, copper ion transmembrane transporter activity, copper-dependent protein binding, cuprous ion binding, metal ion binding, nucleotide binding, protein binding, superoxide dismutase copper chaperone activity; CC: Golgi apparatus, axon, basolateral plasma membrane, bounding membrane of organelle, cell projection, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, dendrite, early endosome membrane, endoplasmic reticulum, endosome, late endosome, melanosome membrane, membrane, neuron projection, neuronal cell body, perinuclear region of cytoplasm, phagocytic vesicle membrane, plasma membrane, postsynaptic density, synapse, trans-Golgi network, trans-Golgi network membrane, trans-Golgi network transport vesicle
Pathways: Antimicrobial peptides, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Copper homeostasis, Detoxification of Reactive Oxygen Species, Immune System, Innate Immune System, Ion channel transport, Ion influx/efflux at host-pathogen interface, Ion transport by P-type ATPases, Mineral absorption - Homo sapiens (human), Transport of small molecules
UniProt: Q04656
Entrez ID: 538
|
Does Activation of LOC105377134 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
LOC105377134
|
protein/peptide accumulation
|
T cell
|
Gene: LOC105377134 (uncharacterized LOC105377134)
Type: ncRNA
Summary: uncharacterized LOC105377134
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 105377134
|
Does Knockout of LAS1L in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
LAS1L
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: LAS1L (LAS1 like ribosome biogenesis factor)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in membrane. Part of MLL1 complex. Implicated in Wilson-Turner syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing; MF: RNA binding, endonuclease activity, hydrolase activity, protein binding; CC: Las1 complex, MLL1 complex, cytoplasm, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y4W2
Entrez ID: 81887
|
Does Knockout of FECH in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
FECH
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: FECH (ferrochelatase)
Type: protein-coding
Summary: The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010].
Gene Ontology: BP: cellular response to dexamethasone stimulus, cholesterol metabolic process, detection of UV, erythrocyte differentiation, generation of precursor metabolites and energy, heme A biosynthetic process, heme B biosynthetic process, heme O biosynthetic process, heme biosynthetic process, multicellular organismal-level iron ion homeostasis, porphyrin-containing compound biosynthetic process, protoporphyrinogen IX metabolic process, regulation of hemoglobin biosynthetic process, response to arsenic-containing substance, response to ethanol, response to insecticide, response to lead ion, response to light stimulus, response to metal ion, response to methylmercury, response to platinum ion, response to xenobiotic stimulus, very-low-density lipoprotein particle assembly; MF: 2 iron, 2 sulfur cluster binding, ferrochelatase activity, ferrous iron binding, heme binding, identical protein binding, iron ion binding, iron-responsive element binding, iron-sulfur cluster binding, lyase activity, metal ion binding, protein binding, protein homodimerization activity, tetrapyrrole binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Acute Intermittent Porphyria, Congenital Erythropoietic Porphyria (CEP) or Gunther Disease, HIF-1-alpha transcription factor network, Heme Biosynthesis, Heme biosynthesis, Hereditary Coproporphyria (HCP), Metabolism, Metabolism of porphyrins, Metabolism of proteins, Mitochondrial protein degradation, Porphyria Variegata (PV), Porphyrin Metabolism, Porphyrin and chlorophyll metabolism - Homo sapiens (human), heme biosynthesis, heme biosynthesis from uroporphyrinogen-III I, hemoglobins chaperone
UniProt: P22830
Entrez ID: 2235
|
Does Knockout of SLC9C1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
SLC9C1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: SLC9C1 (solute carrier family 9 member C1)
Type: protein-coding
Summary: SLC9A10 is a member of the sodium-hydrogen exchanger (NHE) family (see SLC9A1, MIM 107310) and is required for male fertility and sperm motility (Wang et al., 2003 [PubMed 14634667]).[supplied by OMIM, Apr 2009]
Gene Ontology: BP: cell differentiation, flagellated sperm motility, monoatomic cation transport, monoatomic ion transport, potassium ion transmembrane transport, proton transmembrane transport, regulation of intracellular pH, sodium ion import across plasma membrane, sodium ion transport, spermatogenesis, transmembrane transport; MF: antiporter activity, monoatomic ion channel activity, potassium:proton antiporter activity, sodium:proton antiporter activity; CC: cell projection, cilium, membrane, motile cilium, plasma membrane
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q4G0N8
Entrez ID: 285335
|
Does Knockout of OTUD4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
OTUD4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: OTUD4 (OTU deubiquitinase 4)
Type: protein-coding
Summary: Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: DNA alkylation repair, antiviral innate immune response, immune system process, innate immune response, negative regulation of interleukin-1-mediated signaling pathway, negative regulation of toll-like receptor signaling pathway, protein K11-linked deubiquitination, protein K27-linked ubiquitination, protein K48-linked deubiquitination, protein K63-linked deubiquitination, proteolysis, regulation of protein K48-linked deubiquitination; MF: K63-linked deubiquitinase activity, RNA binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, molecular adaptor activity, peptidase activity, protein binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q01804
Entrez ID: 54726
|
Does Knockout of METTL14 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
METTL14
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: METTL14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit)
Type: protein-coding
Summary: Enables mRNA binding activity. Contributes to mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA metabolic process; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of translation. Located in nucleoplasm. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA methylation, cell differentiation, forebrain radial glial cell differentiation, gliogenesis, mRNA destabilization, mRNA export from nucleus, mRNA modification, mRNA processing, mRNA splicing, via spliceosome, mRNA stabilization, negative regulation of hematopoietic progenitor cell differentiation, positive regulation of translation, regulation of neuron differentiation, response to nutrient levels, spermatogenesis, stem cell population maintenance; MF: RNA binding, S-adenosyl-L-methionine binding, S-adenosylmethionine-dependent methyltransferase activity, catalytic activity, acting on a nucleic acid, mRNA binding, mRNA m(6)A methyltransferase activity, protein binding; CC: RNA N6-methyladenosine methyltransferase complex, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA
UniProt: Q9HCE5
Entrez ID: 57721
|
Does Knockout of ENPEP in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
ENPEP
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: ENPEP (glutamyl aminopeptidase)
Type: protein-coding
Summary: The ENPEP gene encodes glutamyl aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19. [provided by RefSeq, Apr 2020].
Gene Ontology: BP: angiogenesis, angiotensin maturation, cell migration, cell population proliferation, cell-cell signaling, glomerulus development, peptide catabolic process, proteolysis, regulation of systemic arterial blood pressure by renin-angiotensin; MF: aminopeptidase activity, glutamyl aminopeptidase activity, hydrolase activity, metal ion binding, metalloaminopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: apical part of cell, apical plasma membrane, brush border, cytoplasmic vesicle, external side of plasma membrane, extracellular exosome, extracellular space, lysosomal membrane, membrane, plasma membrane
Pathways: Metabolism of Angiotensinogen to Angiotensins, Metabolism of proteins, Peptide hormone metabolism, Renin-angiotensin system - Homo sapiens (human)
UniProt: Q07075
Entrez ID: 2028
|
Does Knockout of MTG1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
MTG1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: MTG1 (mitochondrial ribosome associated GTPase 1)
Type: protein-coding
Summary: Enables GTPase activity. Involved in regulation of mitochondrial translation and regulation of respiratory system process. Located in mitochondrial inner membrane and mitochondrial ribosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mitochondrial large ribosomal subunit assembly, regulation of mitochondrial translation, regulation of respiratory system process, regulation of translation; MF: GTP binding, GTPase activity, nucleotide binding, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrion, nucleoplasm
Pathways:
UniProt: Q9BT17
Entrez ID: 92170
|
Does Knockout of SDC2 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
SDC2
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: SDC2 (syndecan 2)
Type: protein-coding
Summary: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, cell migration, dendrite morphogenesis, nervous system development, regulation of dendrite morphogenesis; MF: PDZ domain binding, identical protein binding, protein binding; CC: Golgi lumen, cell surface, endoplasmic reticulum lumen, extracellular matrix, lysosomal lumen, membrane, plasma membrane
Pathways: Attachment and Entry, Axon guidance, Cell adhesion molecules - Homo sapiens (human), Cell surface interactions at the vascular wall, Defective B3GALT6 causes EDSP2 and SEMDJL1, Defective B3GAT3 causes JDSSDHD, Defective B4GALT7 causes EDS, progeroid type, Defective EXT1 causes exostoses 1, TRPS2 and CHDS, Defective EXT2 causes exostoses 2, Developmental Biology, Disease, Diseases associated with glycosaminoglycan metabolism, Diseases of glycosylation, Diseases of metabolism, EPH-Ephrin signaling, EPHB-mediated forward signaling, Early SARS-CoV-2 Infection Events, Extracellular matrix organization, FGF signaling pathway, Fluid shear stress and atherosclerosis - Homo sapiens (human), Glycosaminoglycan metabolism, Glycosaminoglycan-protein linkage region biosynthesis, HS-GAG biosynthesis, HS-GAG degradation, Hemostasis, Heparan sulfate/heparin (HS-GAG) metabolism, Infectious disease, Malaria - Homo sapiens (human), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of fat-soluble vitamins, Metabolism of proteins, Metabolism of vitamins and cofactors, Nervous system development, Non-integrin membrane-ECM interactions, Post-translational protein modification, Post-translational protein phosphorylation, Proteoglycan syndecan-mediated signaling events, Proteoglycans in cancer - Homo sapiens (human), RSV-host interactions, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) attachment and entry, Retinoid metabolism and transport, SARS-CoV Infections, SARS-CoV-2 Infection, SHP2 signaling, Sensory Perception, Syndecan interactions, Syndecan-2-mediated signaling events, TGF_beta_Receptor, Viral Infection Pathways, Visual phototransduction, miRNA targets in ECM and membrane receptors
UniProt: P34741
Entrez ID: 6383
|
Does Knockout of KAAG1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
KAAG1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: KAAG1 (kidney associated DCDC2 antisense RNA 1)
Type: ncRNA
Summary: Predicted to be involved in immune response. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 353219
|
Does Knockout of NISCH in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
NISCH
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: NISCH (nischarin)
Type: protein-coding
Summary: This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: Rac protein signal transduction, actin cytoskeleton organization, apoptotic process, negative regulation of cell migration; MF: identical protein binding, integrin binding, phosphatidylinositol binding, protein binding; CC: cytoplasm, cytosol, early endosome, endosome, intercellular bridge, membrane, microtubule cytoskeleton, nucleoplasm, plasma membrane, recycling endosome
Pathways: RAC1 GTPase cycle, RHO GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9Y2I1
Entrez ID: 11188
|
Does Knockout of TVP23A in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
TVP23A
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TVP23A (trans-golgi network vesicle protein 23 homolog A)
Type: protein-coding
Summary: This gene encodes a membrane protein associated with the Golgi apparatus, which plays a crucial role in intracellular vesicular transport. The encoded protein is likely associated with the late (trans) Golgi compartments, which are involved in the delivery of secretory and membrane proteins to the endosome, lysosome or the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: protein secretion, vesicle-mediated transport; CC: Golgi membrane, membrane
Pathways:
UniProt: A6NH52
Entrez ID: 780776
|
Does Knockout of BUB1 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
BUB1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: BUB1 (BUB1 mitotic checkpoint serine/threonine kinase)
Type: protein-coding
Summary: This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: apoptotic process, cell division, chromatin remodeling, chromosome segregation, intracellular signal transduction, meiotic sister chromatid cohesion, centromeric, mitotic spindle assembly checkpoint signaling, positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric, regulation of chromosome segregation, regulation of sister chromatid cohesion; MF: ATP binding, histone H2A kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, membrane, nucleoplasm, nucleus, outer kinetochore
Pathways: ATM Signaling Network in Development and Disease, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Aurora B signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), PLK1 signaling events, Progesterone-mediated oocyte maturation - Homo sapiens (human), RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of sister chromatid separation at the metaphase-anaphase transition, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, p73 transcription factor network
UniProt: O43683
Entrez ID: 699
|
Does Knockout of RRM1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
RRM1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: RRM1 (ribonucleotide reductase catalytic subunit M1)
Type: protein-coding
Summary: This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: 2'-deoxyribonucleotide biosynthetic process, DNA repair, DNA synthesis involved in DNA repair, cell proliferation in forebrain, deoxyribonucleotide biosynthetic process, male gonad development, mitochondrial DNA replication, positive regulation of G0 to G1 transition, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of G2/M transition of mitotic cell cycle, protein heterotetramerization, pyrimidine nucleobase metabolic process, response to ionizing radiation, retina development in camera-type eye, ribonucleoside diphosphate metabolic process; MF: ATP binding, catalytic activity, disordered domain specific binding, identical protein binding, nucleotide binding, oxidoreductase activity, protein binding, purine nucleotide binding, ribonucleoside-diphosphate reductase activity, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; CC: cell projection, centriolar satellite, ciliary basal body, cytoplasm, cytosol, mitochondrion, neuronal cell body, nuclear envelope, ribonucleoside-diphosphate reductase complex
Pathways: AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Drug metabolism - other enzymes - Homo sapiens (human), E2F transcription factor network, Fluoropyrimidine Activity, Gemcitabine Action Pathway, Gemcitabine Metabolism Pathway, Glutathione metabolism - Homo sapiens (human), Gout or Kelley-Seegmiller Syndrome, Interconversion of nucleotide di- and triphosphates, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide metabolism, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), Retinoblastoma gene in cancer, Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, adenosine deoxyribonucleotides <i>de novo</i> biosynthesis, guanosine deoxyribonucleotides <i>de novo</i> biosynthesis, guanosine nucleotides <i>de novo</i> biosynthesis, purine nucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides biosynthesis from CTP, superpathway of purine nucleotide salvage, superpathway of pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis
UniProt: P23921
Entrez ID: 6240
|
Does Knockout of PITRM1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
PITRM1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PITRM1 (pitrilysin metallopeptidase 1)
Type: protein-coding
Summary: The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. [provided by RefSeq, Dec 2016].
Gene Ontology: BP: protein processing, protein targeting to mitochondrion, proteolysis; MF: enzyme activator activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein binding, zinc ion binding; CC: mitochondrial matrix, mitochondrion
Pathways: Mitochondrial protein import, Protein localization
UniProt: Q5JRX3
Entrez ID: 10531
|
Does Knockout of GTF2H2C in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
GTF2H2C
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: GTF2H2C (GTF2H2 family member C)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in nucleotide-excision repair and regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: metal ion binding, protein binding, zinc ion binding; CC: nuclear speck, nucleus, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Homo sapiens (human), Nucleotide excision repair - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human)
UniProt: Q6P1K8
Entrez ID: 728340
|
Does Knockout of VPS35 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
VPS35
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: VPS35 (VPS35 retromer complex component)
Type: protein-coding
Summary: This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Wnt signaling pathway, endocytic recycling, intracellular protein transport, lysosome organization, mitochondrial fragmentation involved in apoptotic process, mitochondrion to lysosome vesicle-mediated transport, modulation of chemical synaptic transmission, negative regulation of gene expression, negative regulation of inflammatory response, negative regulation of late endosome to lysosome transport, negative regulation of lysosomal protein catabolic process, negative regulation of protein homooligomerization, negative regulation of protein localization, neurotransmitter receptor transport, endosome to plasma membrane, neurotransmitter receptor transport, endosome to postsynaptic membrane, positive regulation of Wnt protein secretion, positive regulation of canonical Wnt signaling pathway, positive regulation of dopamine biosynthetic process, positive regulation of dopamine receptor signaling pathway, positive regulation of gene expression, positive regulation of locomotion involved in locomotory behavior, positive regulation of mitochondrial fission, positive regulation of protein catabolic process, positive regulation of protein localization, positive regulation of protein localization to cell periphery, positive regulation of signal transduction, protein destabilization, protein localization to endosome, protein localization to organelle, protein transport, regulation of dendritic spine maintenance, regulation of developmental process, regulation of macroautophagy, regulation of mitochondrion organization, regulation of postsynapse assembly, regulation of postsynapse organization, regulation of presynapse assembly, regulation of protein catabolic process, regulation of protein metabolic process, regulation of protein stability, regulation of synapse maturation, regulation of terminal button organization, regulation of transport, retrograde transport, endosome to Golgi, transcytosis, vesicle-mediated transport in synapse, voluntary musculoskeletal movement; MF: D1 dopamine receptor binding, protein binding; CC: cytoplasm, cytosol, dopaminergic synapse, early endosome, endosome, endosome membrane, extracellular exosome, glutamatergic synapse, late endosome, lysosomal membrane, lysosome, membrane, mitochondrion, mitochondrion-derived vesicle, neuron projection, neuronal cell body, perinuclear region of cytoplasm, postsynapse, postsynaptic density, presynapse, retromer complex, retromer, cargo-selective complex, synapse, tubular endosome
Pathways: Endocytosis - Homo sapiens (human), Signal Transduction, Signaling by WNT, WNT ligand biogenesis and trafficking
UniProt: Q96QK1
Entrez ID: 55737
|
Does Knockout of CMC2 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
CMC2
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: CMC2 (C-X9-C motif containing 2)
Type: protein-coding
Summary: Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, mitochondrion
Pathways: Mitochondrial protein import, Protein localization
UniProt: Q9NRP2
Entrez ID: 56942
|
Does Activation of SLC35B1 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
SLC35B1
|
protein/peptide accumulation
|
T cell
|
Gene: SLC35B1 (solute carrier family 35 member B1)
Type: protein-coding
Summary: This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: ADP transport, ATP transport, UDP-galactose transmembrane transport, UDP-glucose transmembrane transport, transmembrane transport; MF: ATP:ADP antiporter activity, UDP-galactose transmembrane transporter activity, UDP-glucose transmembrane transporter activity, antiporter activity, protein binding; CC: Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, nucleoplasm
Pathways:
UniProt: P78383
Entrez ID: 10237
|
Does Knockout of TRIM56 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,510
|
Knockout
|
TRIM56
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: TRIM56 (tripartite motif containing 56)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of macromolecule metabolic process; and protein K63-linked ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cGAS/STING signaling pathway, defense response to virus, immune system process, innate immune response, positive regulation of innate immune response, positive regulation of interferon-beta production, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of type I interferon-mediated signaling pathway, protein K63-linked ubiquitination, protein monoubiquitination, protein ubiquitination, regulation of type I interferon production, response to type I interferon; MF: RNA binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Cytosolic sensors of pathogen-associated DNA , Immune System, Innate Immune System, Regulation of innate immune responses to cytosolic DNA
UniProt: Q9BRZ2
Entrez ID: 81844
|
Does Knockout of OXA1L in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
OXA1L
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: OXA1L (OXA1L mitochondrial inner membrane insertase)
Type: protein-coding
Summary: This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: aerobic respiration, mitochondrial protein quality control, mitochondrial proton-transporting ATP synthase complex assembly, mitochondrial respiratory chain complex I assembly, mitochondrial translation, negative regulation of ATP-dependent activity, negative regulation of oxidoreductase activity, protein insertion into mitochondrial inner membrane from matrix, protein tetramerization; MF: membrane insertase activity, mitochondrial ribosome binding, protein binding, protein homodimerization activity; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, protein-containing complex
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Protein export - Homo sapiens (human), Respiratory electron transport, Translation
UniProt: Q15070
Entrez ID: 5018
|
Does Activation of DMAP1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
DMAP1
|
response to virus
|
Hepatoma Cell Line
|
Gene: DMAP1 (DNA methyltransferase 1 associated protein 1)
Type: protein-coding
Summary: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of protein import into nucleus, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, response to ethanol; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, transcription corepressor activity; CC: NuA4 histone acetyltransferase complex, Swr1 complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleosome, nucleus, replication fork
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9NPF5
Entrez ID: 55929
|
Does Knockout of MYO1H in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
MYO1H
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: MYO1H (myosin IH)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin filament organization, actin filament-based movement, endocytosis; MF: ATP binding, actin binding, actin filament binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding; CC: actin cytoskeleton, actin filament, cytoplasm, microvillus, myosin complex, plasma membrane
Pathways: Pathogenic Escherichia coli infection - Homo sapiens (human)
UniProt: A0A140TA25, B4DNW6, S4R387
Entrez ID: 283446
|
Does Knockout of UROS in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
UROS
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: UROS (uroporphyrinogen III synthase)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to amine stimulus, cellular response to arsenic-containing substance, heme A biosynthetic process, heme B biosynthetic process, heme O biosynthetic process, heme biosynthetic process, porphyrin-containing compound biosynthetic process, protoporphyrinogen IX biosynthetic process, response to platinum ion, tetrapyrrole biosynthetic process, uroporphyrinogen III biosynthetic process; MF: folic acid binding, lyase activity, uroporphyrinogen-III synthase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Acute Intermittent Porphyria, Congenital Erythropoietic Porphyria (CEP) or Gunther Disease, Heme Biosynthesis, Heme biosynthesis, Hereditary Coproporphyria (HCP), Metabolism, Metabolism of porphyrins, Porphyria Variegata (PV), Porphyrin Metabolism, Porphyrin and chlorophyll metabolism - Homo sapiens (human), heme biosynthesis, hemoglobins chaperone, tetrapyrrole biosynthesis
UniProt: P10746
Entrez ID: 7390
|
Does Knockout of INTS5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
INTS5
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: INTS5 (integrator complex subunit 5)
Type: protein-coding
Summary: The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, regulation of transcription elongation by RNA polymerase II, snRNA 3'-end processing, snRNA processing; CC: INTAC complex, cytoplasm, cytosol, integrator complex, membrane, nuclear membrane, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q6P9B9
Entrez ID: 80789
|
Does Knockout of CCDC185 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
CCDC185
|
cell proliferation
|
Cancer Cell Line
|
Gene: CCDC185 (coiled-coil domain containing 185)
Type: protein-coding
Summary: coiled-coil domain containing 185
Gene Ontology:
Pathways:
UniProt: Q8N715
Entrez ID: 164127
|
Does Knockout of NEB in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
NEB
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NEB (nebulin)
Type: protein-coding
Summary: This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kD due to alternative splicing that is tissue-, species-,and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Of the several thousand transcript variants predicted for nebulin, the RefSeq Project has decided to create three representative RefSeq records. Mutations in this gene are associated with recessive nemaline myopathy. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cardiac muscle thin filament assembly, muscle organ development, regulation of actin filament length, somatic muscle development; MF: actin binding, actin filament binding, protein binding, structural constituent of muscle; CC: Z disc, actin cytoskeleton, contractile muscle fiber, cytoplasm, cytoskeleton, cytosol, extracellular exosome, myofibril, sarcomere
Pathways: Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Muscle contraction, Striated Muscle Contraction, Striated Muscle Contraction Pathway
UniProt: P20929
Entrez ID: 4703
|
Does Knockout of USP54 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
USP54
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: USP54 (ubiquitin specific peptidase 54)
Type: protein-coding
Summary: Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein deubiquitination, proteolysis; MF: K63-linked deubiquitinase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding
Pathways:
UniProt: Q70EL1
Entrez ID: 159195
|
Does Knockout of SLC25A31 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
SLC25A31
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: SLC25A31 (solute carrier family 25 member 31)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the ADP/ATP carrier family of proteins that exchange cytosolic ADP for matrix ATP in the mitochondria. Cells over-expressing this gene have been shown to display an anti-apoptotic phenotype. This protein is also thought to play a role in spermatogenesis, where it is believed to associate with a part of the flagellar cytoskeleton and with glycolytic enzymes. Male mice with mutations in the mouse ortholog of this gene are sterile and spermatocytes display an early meiotic arrest phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: cell differentiation, male meiosis I, mitochondrial ADP transmembrane transport, mitochondrial ATP transmembrane transport, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, regulation of mitochondrial membrane permeability, spermatogenesis, transmembrane transport; MF: ATP:ADP antiporter activity, antiporter activity, protein binding; CC: cell projection, cilium, membrane, mitochondrial inner membrane, mitochondrial permeability transition pore complex, mitochondrion, motile cilium, nucleus, plasma membrane
Pathways: Alzheimer disease - Homo sapiens (human), Calcium signaling pathway - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Diabetic cardiomyopathy - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), Influenza A - Homo sapiens (human), Necroptosis - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Spinocerebellar ataxia - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: Q9H0C2
Entrez ID: 83447
|
Does Knockout of GGACT in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
GGACT
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: GGACT (gamma-glutamylamine cyclotransferase)
Type: protein-coding
Summary: The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Aug 2010].
Gene Ontology: MF: gamma-glutamylaminecyclotransferase activity, lyase activity, protein binding; CC: cytosol, extracellular exosome
Pathways:
UniProt: Q9BVM4
Entrez ID: 87769
|
Does Knockout of ZNF497 in Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 674
|
Knockout
|
ZNF497
|
cell proliferation
|
Lung Cancer Cell Line
|
Gene: ZNF497 (zinc finger protein 497)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding
Pathways:
UniProt: Q6ZNH5
Entrez ID: 162968
|
Does Knockout of MAT2A in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
MAT2A
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: MAT2A (methionine adenosyltransferase 2A)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: S-adenosylmethionine biosynthetic process, TORC1 signaling, cellular response to amino acid starvation, cellular response to leukemia inhibitory factor, cellular response to methionine, cellular response to nutrient levels, negative regulation of TORC1 signaling, one-carbon metabolic process, positive regulation of TORC1 signaling, protein complex oligomerization, protein heterooligomerization, protein hexamerization, protein localization to lysosome, protein-containing complex localization; MF: ATP binding, identical protein binding, metal ion binding, methionine adenosyltransferase activity, nucleotide binding, protein binding, small molecule binding, transferase activity; CC: cytosol, methionine adenosyltransferase complex
Pathways: Betaine Metabolism, Biological oxidations, C-MYB transcription factor network, Cystathionine Beta-Synthase Deficiency, Cysteine and methionine metabolism - Homo sapiens (human), Glycine N-methyltransferase Deficiency, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, Metabolism, Methionine Adenosyltransferase Deficiency, Methionine De Novo and Salvage Pathway, Methionine Metabolism, Methylation, Methylation Pathways, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), One-carbon metabolism and related pathways, Phase II - Conjugation of compounds, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, S-adenosyl-L-methionine biosynthesis, Selenoamino Acid Metabolism, Spermidine and Spermine Biosynthesis, Trans-sulfuration and one-carbon metabolism, cysteine biosynthesis, methionine degradation, sarcosine oncometabolite pathway , superpathway of methionine degradation
UniProt: P31153
Entrez ID: 4144
|
Does Knockout of NOL6 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
NOL6
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: NOL6 (nucleolar protein 6)
Type: protein-coding
Summary: The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, tRNA export from nucleus; MF: RNA binding, protein binding; CC: CURI complex, UTP-C complex, chromosome, condensed nuclear chromosome, mitochondrion, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q9H6R4
Entrez ID: 65083
|
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