prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of CASS4 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | CASS4 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: CASS4 (Cas scaffold protein family member 4)
Type: protein-coding
Summary: Enables protein tyrosine kinase binding activity. Involved in several processes, including positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; and positive regulation ... |
Does Knockout of HDAC11 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | HDAC11 | cell proliferation | Glioblastoma Cell Line | Gene: HDAC11 (histone deacetylase 11)
Type: protein-coding
Summary: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided... |
Does Knockout of RPL3 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | RPL3 | cell proliferation | Cancer Cell Line | Gene: RPL3 (ribosomal protein L3)
Type: protein-coding
Summary: Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a... |
Does Knockout of METRN in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | METRN | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: METRN (meteorin, glial cell differentiation regulator)
Type: protein-coding
Summary: Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: ax... |
Does Knockout of SLC16A8 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | SLC16A8 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: SLC16A8 (solute carrier family 16 member 8)
Type: protein-coding
Summary: SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010].
Gene Ontology: ... |
Does Knockout of P2RX7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | P2RX7 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: P2RX7 (purinergic receptor P2X 7)
Type: protein-coding
Summary: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable... |
Does Knockout of NOMO1 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | NOMO1 | cell proliferation | T-lymphoma cell line | Gene: NOMO1 (NODAL modulator 1)
Type: protein-coding
Summary: This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely rel... |
Does Knockout of PCDHA13 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | PCDHA13 | cell proliferation | Gastric Cancer Cell Line | Gene: PCDHA13 (protocadherin alpha 13)
Type: protein-coding
Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene cl... |
Does Knockout of MRPL46 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | MRPL46 | cell proliferation | Melanoma Cell Line | Gene: MRPL46 (mitochondrial ribosomal protein L46)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of STC1 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | STC1 | cell proliferation | Hepatoma Cell Line | Gene: STC1 (stanniocalcin 1)
Type: protein-coding
Summary: This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 co... |
Does Knockout of GPR89B in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | GPR89B | cell proliferation | Multiple Myeloma Cell Line | Gene: GPR89B (G protein-coupled receptor 89B)
Type: protein-coding
Summary: Enables voltage-gated anion channel activity. Involved in intracellular pH reduction. Located in Golgi cisterna membrane and Golgi-associated vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene O... |
Does Knockout of TAF1A in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | TAF1A | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: TAF1A (TATA-box binding protein associated factor, RNA polymerase I subunit A)
Type: protein-coding
Summary: This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembl... |
Does Knockout of MAGT1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | MAGT1 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: MAGT1 (magnesium transporter 1)
Type: protein-coding
Summary: This gene encodes a ubiquitously expressed magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutati... |
Does Knockout of NEK6 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | NEK6 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: NEK6 (NIMA related kinase 6)
Type: protein-coding
Summary: The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell ... |
Does Knockout of AOC2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | AOC2 | cell proliferation | Colonic Cancer Cell Line | Gene: AOC2 (amine oxidase copper containing 2)
Type: protein-coding
Summary: Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species r... |
Does Knockout of OR8A1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | OR8A1 | cell proliferation | Bladder Carcinoma | Gene: OR8A1 (olfactory receptor family 8 subfamily A member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of OR5D13 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | OR5D13 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: OR5D13 (olfactory receptor family 5 subfamily D member 13)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of TRRAP in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | TRRAP | cell proliferation | Bladder Carcinoma | Gene: TRRAP (transformation/transcription domain associated protein)
Type: protein-coding
Summary: This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and... |
Does Knockout of SIMC1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | SIMC1 | cell proliferation | Colonic Cancer Cell Line | Gene: SIMC1 (SUMO interacting motifs containing 1)
Type: protein-coding
Summary: Enables SUMO polymer binding activity and peptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Located in sarcomere. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of ZNF681 in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | ZNF681 | cell proliferation | Prostate Cancer Cell Line | Gene: ZNF681 (zinc finger protein 681)
Type: protein-coding
Summary: This gene encodes a protein containing the krueppel associated box (KRAB) and zinc-finger domains, which may be involved in transcriptional regulation. Non-functional alleles of this gene are present in alternate genome assemblies incl... |
Does Knockout of EIF4A1 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | EIF4A1 | cell proliferation | Melanoma Cell Line | Gene: EIF4A1 (eukaryotic translation initiation factor 4A1)
Type: protein-coding
Summary: Enables double-stranded RNA binding activity. Predicted to be involved in cytoplasmic translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP:... |
Does Activation of CIPC in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | CIPC | protein/peptide accumulation | T cell | Gene: CIPC (CLOCK interacting pacemaker)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of circadian rhythm and negative regulation of transcription, DNA-templated. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of BCL7B in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | BCL7B | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: BCL7B (BAF chromatin remodeling complex subunit BCL7B)
Type: protein-coding
Summary: This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. T... |
Does Knockout of EXOC8 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | EXOC8 | cell proliferation | Cancer Cell Line | Gene: EXOC8 (exocyst complex component 8)
Type: protein-coding
Summary: This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma mem... |
Does Knockout of RAB23 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | RAB23 | response to chemicals | Melanoma Cell Line | Gene: RAB23 (RAB23, member RAS oncogene family)
Type: protein-coding
Summary: This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to ... |
Does Knockout of LLPH in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | LLPH | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: LLPH (LLP homolog, long-term synaptic facilitation factor)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in dendrite extension and positive regulation of dendritic spine development. Located in chromosome and nucleolus. [provided by Alliance of Genome Resourc... |
Does Knockout of HSP90B1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | HSP90B1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: HSP90B1 (heat shock protein 90 beta family member 1)
Type: protein-coding
Summary: This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the e... |
Does Knockout of STEAP3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | STEAP3 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: STEAP3 (STEAP3 metalloreductase)
Type: protein-coding
Summary: This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting ... |
Does Knockout of FRMD1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | FRMD1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: FRMD1 (FERM domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in positive regulation of hippo signaling. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasmic side of apical plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of GOLGA8O in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | GOLGA8O | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: GOLGA8O (golgin A8 family member O)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Apr... |
Does Knockout of NEB in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | NEB | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: NEB (nebulin)
Type: protein-coding
Summary: This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein.... |
Does Knockout of CNN1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | CNN1 | cell proliferation | Endometrial Cancer Cell Line | Gene: CNN1 (calponin 1)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Involved in negative regulation of vascular associated smooth muscle cell proliferation. Located in cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin filam... |
Does Knockout of NRBF2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | NRBF2 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: NRBF2 (nuclear receptor binding factor 2)
Type: protein-coding
Summary: Involved in autophagy. Located in cytoplasm. Colocalizes with phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagy, response to endoplasmi... |
Does Knockout of INTS3 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | INTS3 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: INTS3 (integrator complex subunit 3)
Type: protein-coding
Summary: The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part... |
Does Knockout of MCM5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | MCM5 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: MCM5 (minichromosome maintenance complex component 5)
Type: protein-coding
Summary: The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of c... |
Does Knockout of ELP5 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | ELP5 | cell proliferation | Gastric Cancer Cell Line | Gene: ELP5 (elongator acetyltransferase complex subunit 5)
Type: protein-coding
Summary: Predicted to contribute to tRNA binding activity. Predicted to be involved in positive regulation of cell migration and tRNA modification. Located in cytosol and nucleoplasm. Part of elongator holoenzyme complex. [p... |
Does Knockout of MRPL33 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | MRPL33 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: MRPL33 (mitochondrial ribosomal protein L33)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of INO80 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | INO80 | cell proliferation | Monocytic Leukemia Cell Line | Gene: INO80 (INO80 complex ATPase subunit)
Type: protein-coding
Summary: This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 ... |
Does Knockout of KLC2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | KLC2 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: KLC2 (kinesin light chain 2)
Type: protein-coding
Summary: The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN... |
Does Knockout of ATP6V1G1 in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | ATP6V1G1 | response to virus | Hepatoma Cell Line | Gene: ATP6V1G1 (ATPase H+ transporting V1 subunit G1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intr... |
Does Knockout of GRIPAP1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | GRIPAP1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: GRIPAP1 (GRIP1 associated protein 1)
Type: protein-coding
Summary: This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regula... |
Does Knockout of HLA-DMB in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | HLA-DMB | cell proliferation | Melanoma Cell Line | Gene: HLA-DMB (major histocompatibility complex, class II, DM beta)
Type: protein-coding
Summary: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intrac... |
Does Knockout of TRAF4 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | TRAF4 | cell proliferation | Breast Cancer Cell Line | Gene: TRAF4 (TNF receptor associated factor 4)
Type: protein-coding
Summary: This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown... |
Does Knockout of SIRPB2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | SIRPB2 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: SIRPB2 (signal regulatory protein beta 2)
Type: protein-coding
Summary: Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, plasma membrane
Pathways:
... |
Does Knockout of PLK1 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | PLK1 | cell proliferation | Breast Cancer Cell Line | Gene: PLK1 (polo like kinase 1)
Type: protein-coding
Summary: The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically ... |
Does Knockout of RPL15 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | RPL15 | cell proliferation | Glioblastoma Cell Line | Gene: RPL15 (ribosomal protein L15)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene enc... |
Does Knockout of SOS1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | SOS1 | cell proliferation | Glioblastoma Cell Line | Gene: SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Type: protein-coding
Summary: This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates an... |
Does Knockout of PIGR in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | PIGR | cell proliferation | Bladder Carcinoma | Gene: PIGR (polymeric immunoglobulin receptor)
Type: protein-coding
Summary: This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to b... |
Does Knockout of HDAC3 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | HDAC3 | cell proliferation | Cancer Cell Line | Gene: HDAC3 (histone deacetylase 3)
Type: protein-coding
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encod... |
Does Knockout of JADE2 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | JADE2 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: JADE2 (jade family PHD finger 2)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Involved in histone acetylation. Located in nucleoplasm. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP:... |
Does Knockout of DDN in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | DDN | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: DDN (dendrin)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within positive regulation of transcription by R... |
Does Knockout of SGO2 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | SGO2 | cell proliferation | Cancer Cell Line | Gene: SGO2 (shugoshin 2)
Type: protein-coding
Summary: Predicted to be involved in homologous chromosome segregation; meiotic sister chromatid cohesion; and mitotic sister chromatid segregation. Predicted to act upstream of or within meiotic nuclear division; positive regulation of maintenance of meioti... |
Does Knockout of TTC14 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | TTC14 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: TTC14 (tetratricopeptide repeat domain 14)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: Ectoderm Differentiation
UniProt: Q96N46
Entrez ID: 151613 |
Does Knockout of SCGB3A2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | SCGB3A2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SCGB3A2 (secretoglobin family 3A member 2)
Type: protein-coding
Summary: The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma... |
Does Knockout of EXOSC9 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | EXOSC9 | cell proliferation | Glioblastoma Cell Line | Gene: EXOSC9 (exosome component 9)
Type: protein-coding
Summary: This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen co... |
Does Knockout of INPP5B in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | INPP5B | cell proliferation | Cancer Cell Line | Gene: INPP5B (inositol polyphosphate-5-phosphatase B)
Type: protein-coding
Summary: This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the ... |
Does Knockout of PCP2 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | PCP2 | cell proliferation | Gastric Cancer Cell Line | Gene: PCP2 (Purkinje cell protein 2)
Type: protein-coding
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within rhodopsin mediated signaling pathway. Predicted to be located in neurona... |
Does Knockout of COPZ1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | COPZ1 | cell proliferation | Gastric Cancer Cell Line | Gene: COPZ1 (coat protein complex I subunit zeta 1)
Type: protein-coding
Summary: This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as th... |
Does Knockout of RAD51AP1 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | RAD51AP1 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: RAD51AP1 (RAD51 associated protein 1)
Type: protein-coding
Summary: Enables nucleic acid binding activity. Involved in DNA repair; cellular response to ionizing radiation; and positive regulation of DNA recombination. Located in chromatin and nucleus. Part of protein-containing complex. [provided ... |
Does Knockout of ARMC7 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | ARMC7 | cell proliferation | Neuroblastoma Cell Line | Gene: ARMC7 (armadillo repeat containing 7)
Type: protein-coding
Summary: Predicted to be involved in RNA splicing and mRNA processing. Predicted to be part of spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing
Pa... |
Does Knockout of PTPN12 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | PTPN12 | cell proliferation | Colonic Cancer Cell Line | Gene: PTPN12 (protein tyrosine phosphatase non-receptor type 12)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation,... |
Does Knockout of MAP7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | MAP7 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: MAP7 (microtubule associated protein 7)
Type: protein-coding
Summary: The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential f... |
Does Knockout of NHP2 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | NHP2 | cell proliferation | Breast Cancer Cell Line | Gene: NHP2 (NHP2 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA ... |
Does Knockout of ANKRD1 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | ANKRD1 | cell proliferation | Cancer Cell Line | Gene: ANKRD1 (ankyrin repeat domain 1)
Type: protein-coding
Summary: The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions ... |
Does Knockout of RPL28 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | RPL28 | cell proliferation | Colonic Cancer Cell Line | Gene: RPL28 (ribosomal protein L28)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of LAMTOR3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | LAMTOR3 | cell proliferation | Endometrial Cancer Cell Line | Gene: LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3)
Type: protein-coding
Summary: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding pr... |
Does Knockout of SNRPB in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | SNRPB | cell proliferation | Melanoma Cell Line | Gene: SNRPB (small nuclear ribonucleoprotein polypeptides B and B1)
Type: protein-coding
Summary: The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA spl... |
Does Knockout of SDHD in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | SDHD | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SDHD (succinate dehydrogenase complex subunit D)
Type: protein-coding
Summary: This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix si... |
Does Knockout of CD2BP2 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | CD2BP2 | cell proliferation | Medulloblastoma Cell Line | Gene: CD2BP2 (CD2 cytoplasmic tail binding protein 2)
Type: protein-coding
Summary: This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. ... |
Does Knockout of METTL22 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | METTL22 | cell proliferation | Melanoma Cell Line | Gene: METTL22 (methyltransferase 22, Kin17 lysine)
Type: protein-coding
Summary: This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple ... |
Does Knockout of TAS2R14 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | TAS2R14 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: TAS2R14 (taste 2 receptor member 14)
Type: protein-coding
Summary: This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epi... |
Does Knockout of PTAFR in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | PTAFR | response to virus | Huh-7 Cell | Gene: PTAFR (platelet activating factor receptor)
Type: protein-coding
Summary: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholi... |
Does Knockout of PRRG2 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | PRRG2 | cell proliferation | Breast Cancer Cell Line | Gene: PRRG2 (proline rich and Gla domain 2)
Type: protein-coding
Summary: The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed o... |
Does Knockout of PANK3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | PANK3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: PANK3 (pantothenate kinase 3)
Type: protein-coding
Summary: This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the ... |
Does Knockout of PPP1R8 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | PPP1R8 | cell proliferation | Bladder Carcinoma | Gene: PPP1R8 (protein phosphatase 1 regulatory subunit 8)
Type: protein-coding
Summary: This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not... |
Does Knockout of CHMP7 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | CHMP7 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CHMP7 (charged multivesicular body protein 7)
Type: protein-coding
Summary: Involved in several processes, including late endosome to vacuole transport; midbody abscission; and mitotic nuclear division. Located in cytosol; nuclear envelope; and nucleoplasm. Part of ESCRT III complex. Colocalizes w... |
Does Knockout of ELOC in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | ELOC | cell proliferation | Endometrial Cancer Cell Line | Gene: ELOC (elongin C)
Type: protein-coding
Summary: This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the poly... |
Does Knockout of HSPA2 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | HSPA2 | cell proliferation | Hepatoma Cell Line | Gene: HSPA2 (heat shock protein family A (Hsp70) member 2)
Type: protein-coding
Summary: Enables disordered domain specific binding activity; enzyme binding activity; and unfolded protein binding activity. Involved in negative regulation of inclusion body assembly and protein refolding. Located in cytos... |
Does Knockout of ADCK2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | ADCK2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ADCK2 (aarF domain containing kinase 2)
Type: protein-coding
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resource... |
Does Inhibition of MRPL39 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,184 | Inhibition | MRPL39 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: MRPL39 (mitochondrial ribosomal protein L39)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of GPR108 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | GPR108 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: GPR108 (G protein-coupled receptor 108)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of toll-like receptor signaling pathway. Located in trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: defense response to virus,... |
Does Knockout of NUP155 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | NUP155 | cell proliferation | Colonic Cancer Cell Line | Gene: NUP155 (nucleoporin 155)
Type: protein-coding
Summary: Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a r... |
Does Activation of CD59 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | CD59 | response to virus | Hepatoma Cell Line | Gene: CD59 (CD59 molecule (CD59 blood group))
Type: protein-coding
Summary: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whe... |
Does Activation of RRAD in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | RRAD | protein/peptide accumulation | T cell | Gene: RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator)
Type: protein-coding
Summary: Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to be located in cytosol. Pred... |
Does Knockout of CPXM2 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | CPXM2 | response to virus | Hepatoma Cell Line | Gene: CPXM2 (carboxypeptidase X, M14 family member 2)
Type: protein-coding
Summary: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources... |
Does Knockout of GLRX5 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | GLRX5 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: GLRX5 (glutaredoxin 5)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessiv... |
Does Knockout of PAG1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | PAG1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1)
Type: protein-coding
Summary: The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.... |
Does Knockout of ZNF292 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | ZNF292 | cell proliferation | Colonic Cancer Cell Line | Gene: ZNF292 (zinc finger protein 292)
Type: protein-coding
Summary: This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocy... |
Does Knockout of MED23 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | MED23 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: MED23 (mediator complex subunit 23)
Type: protein-coding
Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA pol... |
Does Knockout of ARHGAP44 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | ARHGAP44 | response to chemicals | Monocytic Leukemia Cell Line | Gene: ARHGAP44 (Rho GTPase activating protein 44)
Type: protein-coding
Summary: Enables phospholipid binding activity. Predicted to be involved in several processes, including modification of dendritic spine; negative regulation of Rac protein signal transduction; and regulation of plasma membrane bound... |
Does Knockout of RRM1 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | RRM1 | cell proliferation | Cancer Cell Line | Gene: RRM1 (ribonucleotide reductase catalytic subunit M1)
Type: protein-coding
Summary: This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is importa... |
Does Knockout of DUT in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | DUT | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: DUT (deoxyuridine triphosphatase)
Type: protein-coding
Summary: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a prec... |
Does Knockout of NOL12 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | NOL12 | cell proliferation | Medulloblastoma Cell Line | Gene: NOL12 (nucleolar protein 12)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, identical protein binding, protein binding, rRNA binding, single... |
Does Knockout of NPLOC4 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | NPLOC4 | cell proliferation | Multiple Myeloma Cell Line | Gene: NPLOC4 (NPL4 homolog, ubiquitin recognition factor)
Type: protein-coding
Summary: Predicted to enable ATPase binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activ... |
Does Knockout of RAD51B in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | RAD51B | response to virus | Lung Cancer Cell Line | Gene: RAD51B (RAD51 paralog B)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer... |
Does Knockout of SND1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | SND1 | cell proliferation | Melanoma Cell Line | Gene: SND1 (staphylococcal nuclease and tudor domain containing 1)
Type: protein-coding
Summary: This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transfor... |
Does Knockout of RPS11 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | RPS11 | cell proliferation | Colorectal Cancer Cell Line | Gene: RPS11 (ribosomal protein S11)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of CHMP5 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | CHMP5 | cell proliferation | Melanoma Cell Line | Gene: CHMP5 (charged multivesicular body protein 5)
Type: protein-coding
Summary: CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in d... |
Does Knockout of B2M in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | B2M | response to virus | Hepatoma Cell Line | Gene: B2M (beta-2-microglobulin)
Type: protein-coding
Summary: This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can fo... |
Does Knockout of TBXT in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | TBXT | response to virus | Cervical Adenocarcinoma Cell Line | Gene: TBXT (T-box transcription factor T)
Type: protein-coding
Summary: The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of ... |
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