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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of CASS4 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
CASS4
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: CASS4 (Cas scaffold protein family member 4)
Type: protein-coding
Summary: Enables protein tyrosine kinase binding activity. Involved in several processes, including positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; and positive regulation of substrate adhesion-dependent cell spreading. Located in focal adhesion. Part of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell adhesion, cell migration, cell surface receptor protein tyrosine kinase signaling pathway, positive regulation of cell migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein tyrosine kinase activity, positive regulation of substrate adhesion-dependent cell spreading; MF: protein binding, protein tyrosine kinase binding; CC: anchoring junction, cytoplasm, cytoskeleton, focal adhesion, plasma membrane
Pathways:
UniProt: Q9NQ75
Entrez ID: 57091
|
Does Knockout of HDAC11 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
HDAC11
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: HDAC11 (histone deacetylase 11)
Type: protein-coding
Summary: This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009].
Gene Ontology: BP: chromatin organization, epigenetic regulation of gene expression; MF: DNA-binding transcription factor binding, histone deacetylase activity, histone deacetylase activity, hydrolytic mechanism, hydrolase activity, protein binding; CC: histone deacetylase complex, nucleus, plasma membrane
Pathways: Alcoholism - Homo sapiens (human), Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Gene expression (Transcription), Generic Transcription Pathway, NOTCH1 Intracellular Domain Regulates Transcription, Neural Crest Differentiation, Neutrophil extracellular trap formation - Homo sapiens (human), Notch-HLH transcription pathway, RNA Polymerase II Transcription, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling events mediated by HDAC Class II, Viral carcinogenesis - Homo sapiens (human)
UniProt: Q96DB2
Entrez ID: 79885
|
Does Knockout of RPL3 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
RPL3
|
cell proliferation
|
Cancer Cell Line
|
Gene: RPL3 (ribosomal protein L3)
Type: protein-coding
Summary: Ribosomes, the complexes that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L3P family of ribosomal proteins and it is located in the cytoplasm. The protein can bind to the HIV-1 TAR mRNA, and it has been suggested that the protein contributes to tat-mediated transactivation. This gene is co-transcribed with several small nucleolar RNA genes, which are located in several of this gene's introns. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to interleukin-4, cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, nucleolus, nucleus, protein-containing complex, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P39023
Entrez ID: 6122
|
Does Knockout of METRN in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
METRN
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: METRN (meteorin, glial cell differentiation regulator)
Type: protein-coding
Summary: Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: axonogenesis, cell differentiation, glial cell differentiation, nervous system development, positive regulation of axonogenesis, radial glial cell differentiation, signal transduction; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9UJH8
Entrez ID: 79006
|
Does Knockout of SLC16A8 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
SLC16A8
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: SLC16A8 (solute carrier family 16 member 8)
Type: protein-coding
Summary: SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010].
Gene Ontology: BP: lactate transmembrane transport, lactate transport, monocarboxylic acid transport, transmembrane transport; MF: lactate transmembrane transporter activity, monocarboxylic acid transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: apical part of cell, apical plasma membrane, basolateral plasma membrane, membrane, plasma membrane
Pathways: Basigin interactions, Cell surface interactions at the vascular wall, Hemostasis, Proton-coupled monocarboxylate transport, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: O95907
Entrez ID: 23539
|
Does Knockout of P2RX7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
P2RX7
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: P2RX7 (purinergic receptor P2X 7)
Type: protein-coding
Summary: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: MAPK cascade, NAD transport, T cell apoptotic process, T cell homeostasis, T cell mediated cytotoxicity, T cell proliferation, apoptotic signaling pathway, bleb assembly, calcium ion transmembrane transport, calcium ion transport, calcium-mediated signaling, cell morphogenesis, cell surface receptor signaling pathway, cell volume homeostasis, cellular response to ATP, cellular response to dsRNA, ceramide biosynthetic process, collagen metabolic process, defense response to Gram-positive bacterium, establishment of localization in cell, excitatory postsynaptic potential, extrinsic apoptotic signaling pathway, gamma-aminobutyric acid secretion, gene expression, glutamate secretion, homeostasis of number of cells within a tissue, inflammatory response, lymphocyte apoptotic process, membrane depolarization, membrane protein ectodomain proteolysis, mitochondrial depolarization, mitochondrion organization, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of MAPK cascade, negative regulation of bone resorption, negative regulation of cell volume, organophosphate ester transport, phagolysosome assembly, phospholipid transfer to membrane, phospholipid translocation, plasma membrane organization, plasma membrane phospholipid scrambling, pore complex assembly, positive regulation of MAPK cascade, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of T cell apoptotic process, positive regulation of T cell mediated cytotoxicity, positive regulation of apoptotic process, positive regulation of bleb assembly, positive regulation of bone mineralization, positive regulation of calcium ion transport into cytosol, positive regulation of cellular component organization, positive regulation of cytoskeleton organization, positive regulation of gamma-aminobutyric acid secretion, positive regulation of gene expression, positive regulation of glutamate secretion, positive regulation of glycolytic process, positive regulation of interleukin-1 alpha production, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, positive regulation of lymphocyte apoptotic process, positive regulation of macrophage cytokine production, positive regulation of mitochondrial depolarization, positive regulation of monoatomic ion transmembrane transport, positive regulation of ossification, positive regulation of prostaglandin secretion, positive regulation of protein secretion, potassium ion transmembrane transport, programmed cell death, prostaglandin secretion, protein catabolic process, protein homotrimerization, protein processing, protein secretion, purinergic nucleotide receptor signaling pathway, reactive oxygen species metabolic process, regulation of sodium ion transport, regulation of transport, release of sequestered calcium ion into cytosol, response to ATP, response to bacterium, response to calcium ion, response to electrical stimulus, response to fluid shear stress, response to ischemia, response to lipopolysaccharide, response to mechanical stimulus, response to xenobiotic stimulus, response to zinc ion, sensory perception of pain, skeletal system morphogenesis, sodium ion transmembrane transport, synaptic vesicle exocytosis, vesicle budding from membrane; MF: ATP binding, GTP binding, channel activity, extracellularly ATP-gated monoatomic cation channel activity, identical protein binding, lipopolysaccharide binding, metal ion binding, monoatomic ion channel activity, nucleotide binding, potassium channel activity, protein binding, purinergic nucleotide receptor activity, signaling receptor activity, signaling receptor binding, sodium channel activity; CC: bleb, cell-cell junction, cytoplasm, external side of plasma membrane, membrane, mitochondrion, neuromuscular junction, neuronal cell body, plasma membrane, postsynapse, presynapse, synapse
Pathways: Calcium signaling pathway - Homo sapiens (human), Cell recruitment (pro-inflammatory response), Cellular responses to mechanical stimuli, Cellular responses to stimuli, Disease, Elevation of cytosolic Ca2+ levels, Hemostasis, Immune System, Infectious disease, Inflammasomes, Innate Immune System, Leishmania infection, Mechanical load activates signaling by PIEZO1 and integrins in osteocytes, NOD-like receptor signaling pathway - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Parasitic Infection Pathways, Platelet calcium homeostasis, Platelet homeostasis, Purinergic signaling, Purinergic signaling in leishmaniasis infection, The NLRP3 inflammasome
UniProt: Q99572
Entrez ID: 5027
|
Does Knockout of NOMO1 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
NOMO1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: NOMO1 (NODAL modulator 1)
Type: protein-coding
Summary: This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). [provided by RefSeq, Jul 2008].
Gene Ontology: BP: determination of left/right asymmetry in lateral mesoderm, multi-pass transmembrane protein insertion into ER membrane, negative regulation of nodal signaling pathway; MF: carbohydrate binding, protein binding, ribosome binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, multi-pass translocon complex
Pathways:
UniProt: Q15155
Entrez ID: 23420
|
Does Knockout of PCDHA13 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
PCDHA13
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PCDHA13 (protocadherin alpha 13)
Type: protein-coding
Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, nervous system development; MF: calcium ion binding, cell adhesion molecule binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q9Y5I0
Entrez ID: 56136
|
Does Knockout of MRPL46 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
MRPL46
|
cell proliferation
|
Melanoma Cell Line
|
Gene: MRPL46 (mitochondrial ribosomal protein L46)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: structural constituent of ribosome; CC: cell junction, cytosol, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q9H2W6
Entrez ID: 26589
|
Does Knockout of STC1 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
STC1
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: STC1 (stanniocalcin 1)
Type: protein-coding
Summary: This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: bone development, cellular response to cAMP, cellular response to glucocorticoid stimulus, cellular response to hypoxia, chondrocyte proliferation, decidualization, embryo implantation, endothelial cell morphogenesis, growth plate cartilage axis specification, intracellular calcium ion homeostasis, negative regulation of calcium ion transport, negative regulation of cell migration, negative regulation of endothelial cell migration, negative regulation of renal phosphate excretion, ossification, positive regulation of calcium ion import, regulation of cardiac muscle cell contraction, regulation of monoatomic anion transport, response to vitamin D, signal transduction; MF: hormone activity, identical protein binding, protein binding; CC: apical plasma membrane, cytoplasm, extracellular region, extracellular space, nucleus
Pathways: Ectoderm Differentiation
UniProt: P52823
Entrez ID: 6781
|
Does Knockout of GPR89B in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
GPR89B
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: GPR89B (G protein-coupled receptor 89B)
Type: protein-coding
Summary: Enables voltage-gated anion channel activity. Involved in intracellular pH reduction. Located in Golgi cisterna membrane and Golgi-associated vesicle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: T cell differentiation, intracellular pH reduction, monoatomic anion transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, protein transport; MF: protein binding, voltage-gated monoatomic anion channel activity; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, membrane, monoatomic ion channel complex
Pathways:
UniProt: P0CG08, B7ZAQ6
Entrez ID: 51463
|
Does Knockout of TAF1A in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
TAF1A
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TAF1A (TATA-box binding protein associated factor, RNA polymerase I subunit A)
Type: protein-coding
Summary: This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011].
Gene Ontology: BP: transcription by RNA polymerase I, transcription by RNA polymerase II; MF: DNA binding, protein binding; CC: RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, microtubule cytoskeleton, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, SIRT1 negatively regulates rRNA expression
UniProt: Q15573
Entrez ID: 9015
|
Does Knockout of MAGT1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
MAGT1
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: MAGT1 (magnesium transporter 1)
Type: protein-coding
Summary: This gene encodes a ubiquitously expressed magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause a form of X-linked intellectual disability (XLID). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: cognition, magnesium ion transmembrane transport, magnesium ion transport, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, transmembrane transport; MF: magnesium ion transmembrane transporter activity; CC: azurophil granule membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex B, plasma membrane
Pathways: Adaptive Immune System, Asparagine N-linked glycosylation, Co-inhibition by PD-1, Disease, Immune System, Infectious disease, Innate Immune System, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, Miscellaneous transport and binding events, Neutrophil degranulation, PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Transport of small molecules, Viral Infection Pathways
UniProt: Q9H0U3
Entrez ID: 84061
|
Does Knockout of NEK6 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
NEK6
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: NEK6 (NIMA related kinase 6)
Type: protein-coding
Summary: The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: apoptotic process, cell division, chromosome segregation, mitotic nuclear membrane disassembly, mitotic spindle organization, peptidyl-serine phosphorylation, positive regulation of canonical NF-kappaB signal transduction, protein autophosphorylation, protein phosphorylation, regulation of cellular senescence, regulation of chromosome organization, regulation of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, spindle assembly; MF: ATP binding, DNA-binding transcription factor binding, kinase activity, kinesin binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transcription corepressor binding, transferase activity, ubiquitin protein ligase binding; CC: centriolar satellite, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule, nuclear speck, nucleoplasm, nucleus, protein-containing complex, spindle pole
Pathways:
UniProt: Q9HC98
Entrez ID: 10783
|
Does Knockout of AOC2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
AOC2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: AOC2 (amine oxidase copper containing 2)
Type: protein-coding
Summary: Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: amine metabolic process, catecholamine metabolic process, visual perception, xenobiotic metabolic process; MF: copper ion binding, electron transfer activity, metal ion binding, oxidoreductase activity, primary methylamine oxidase activity, protein binding, quinone binding; CC: cytoplasm, membrane, plasma membrane
Pathways: Biological oxidations, Glycine, serine and threonine metabolism - Homo sapiens (human), Metabolism, Phase I - Functionalization of compounds, Phenylalanine metabolism - Homo sapiens (human), Tyrosine metabolism - Homo sapiens (human), beta-Alanine metabolism - Homo sapiens (human), phenylethylamine degradation I
UniProt: O75106
Entrez ID: 314
|
Does Knockout of OR8A1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
OR8A1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: OR8A1 (olfactory receptor family 8 subfamily A member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGG7
Entrez ID: 390275
|
Does Knockout of OR5D13 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
OR5D13
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: OR5D13 (olfactory receptor family 5 subfamily D member 13)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGL4
Entrez ID: 390142
|
Does Knockout of TRRAP in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
TRRAP
|
cell proliferation
|
Bladder Carcinoma
|
Gene: TRRAP (transformation/transcription domain associated protein)
Type: protein-coding
Summary: This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: DNA repair-dependent chromatin remodeling, chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of apoptotic process, regulation of cell cycle, regulation of cellular response to stress, regulation of double-strand break repair, regulation of transcription by RNA polymerase II; MF: kinase activity, protein binding, transcription coregulator activity; CC: Golgi apparatus, NuA4 histone acetyltransferase complex, SAGA complex, Swr1 complex, nucleoplasm, nucleosome, nucleus, transcription factor TFTC complex
Pathways: C-MYC pathway, Direct p53 effectors, E2F transcription factor network, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Regulation of nuclear beta catenin signaling and target gene transcription, Rett syndrome causing genes, Validated targets of C-MYC transcriptional activation, multi-step regulation of transcription by pitx2
UniProt: Q9Y4A5
Entrez ID: 8295
|
Does Knockout of SIMC1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
SIMC1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SIMC1 (SUMO interacting motifs containing 1)
Type: protein-coding
Summary: Enables SUMO polymer binding activity and peptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Located in sarcomere. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: SUMO polymer binding, peptidase inhibitor activity, protein binding; CC: PML body, cytoplasm, nucleus, sarcomere
Pathways:
UniProt: Q8NDZ2
Entrez ID: 375484
|
Does Knockout of ZNF681 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
ZNF681
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: ZNF681 (zinc finger protein 681)
Type: protein-coding
Summary: This gene encodes a protein containing the krueppel associated box (KRAB) and zinc-finger domains, which may be involved in transcriptional regulation. Non-functional alleles of this gene are present in alternate genome assemblies including T2T-CHM13v1.1, resulting from a 'TG' deletion (rs61397759) which causes a frameshift and a premature stop codon. [provided by RefSeq, Sep 2022].
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q96N22
Entrez ID: 148213
|
Does Knockout of EIF4A1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
EIF4A1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: EIF4A1 (eukaryotic translation initiation factor 4A1)
Type: protein-coding
Summary: Enables double-stranded RNA binding activity. Predicted to be involved in cytoplasmic translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic translational initiation, positive regulation of transcription by RNA polymerase II, translation, translational initiation; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA cap binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, cytoplasmic stress granule, cytosol, eukaryotic translation initiation factor 4F complex, extracellular exosome, membrane, nuclear stress granule, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, Cytokine Signaling in Immune system, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Developmental Biology, Eukaryotic Translation Initiation, Fragile X Syndrome, GTP hydrolysis and joining of the 60S ribosomal subunit, ISG15 antiviral mechanism, Immune System, Interferon Signaling, Interferon type I signaling pathways, L13a-mediated translational silencing of Ceruloplasmin expression, M-decay: degradation of maternal mRNAs by maternally stored factors, Maternal to zygotic transition (MZT), Metabolism of RNA, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation inhibitors in chronically activated PDGFRA cells, Translation initiation complex formation, Validated targets of C-MYC transcriptional activation, Z-decay: degradation of maternal mRNAs by zygotically expressed factors, eukaryotic protein translation, internal ribosome entry pathway, mTOR signaling pathway, mtor signaling pathway, regulation of eif-4e and p70s6 kinase, skeletal muscle hypertrophy is regulated via akt-mtor pathway
UniProt: P60842
Entrez ID: 1973
|
Does Activation of CIPC in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
CIPC
|
protein/peptide accumulation
|
T cell
|
Gene: CIPC (CLOCK interacting pacemaker)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of circadian rhythm and negative regulation of transcription, DNA-templated. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of circadian rhythm, rhythmic process; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Circadian clock, Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
UniProt: Q9C0C6
Entrez ID: 85457
|
Does Knockout of BCL7B in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
BCL7B
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: BCL7B (BAF chromatin remodeling complex subunit BCL7B)
Type: protein-coding
Summary: This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010].
Gene Ontology: BP: Wnt signaling pathway, apoptotic process, cell differentiation, chromatin remodeling, negative regulation of cell differentiation, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of stem cell population maintenance, regulation of G0 to G1 transition, regulation of G1/S transition of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II; MF: actin binding, protein binding; CC: GBAF complex, SWI/SNF complex, chromatin, nucleoplasm
Pathways: ATP-dependent chromatin remodelers, Chromatin organization, Developmental Biology, Epigenetic regulation of gene expression, Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF), Formation of the canonical BAF (cBAF) complex, Formation of the embryonic stem cell BAF (esBAF) complex, Formation of the non-canonical BAF (ncBAF) complex, Formation of the polybromo-BAF (pBAF) complex, Gene expression (Transcription), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Regulation of MITF-M-dependent genes involved in pigmentation, Regulation of endogenous retroelements, Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs), SWI/SNF chromatin remodelers
UniProt: Q9BQE9
Entrez ID: 9275
|
Does Knockout of EXOC8 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
EXOC8
|
cell proliferation
|
Cancer Cell Line
|
Gene: EXOC8 (exocyst complex component 8)
Type: protein-coding
Summary: This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: Golgi to plasma membrane transport, endosome organization, exocytosis, extracellular matrix disassembly, intracellular protein localization, membrane fission, mitotic cytokinesis, protein transport, regulation of macroautophagy, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; MF: phosphatidylinositol binding, protein binding, small GTPase binding; CC: cell periphery, cell projection, cytoplasm, cytosol, exocyst, growth cone, late endosome, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Cargo trafficking to the periciliary membrane, Ciliary landscape, Cilium Assembly, Insulin processing, Membrane Trafficking, Metabolism of proteins, Organelle biogenesis and maintenance, Peptide hormone metabolism, RalA downstream regulated genes, Translocation of SLC2A4 (GLUT4) to the plasma membrane, Vesicle-mediated transport, VxPx cargo-targeting to cilium
UniProt: Q8IYI6
Entrez ID: 149371
|
Does Knockout of RAB23 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
RAB23
|
response to chemicals
|
Melanoma Cell Line
|
Gene: RAB23 (RAB23, member RAS oncogene family)
Type: protein-coding
Summary: This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: GTP metabolic process, anatomical structure morphogenesis, autophagosome assembly, cellular defense response, cilium assembly, craniofacial suture morphogenesis, intracellular protein transport, negative regulation of protein import into nucleus, protein transport, system development; MF: GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: autophagosome, cell junction, centrosome, ciliary basal body, cilium, cytoplasm, cytoplasmic vesicle, cytosol, endomembrane system, endosome, endosome membrane, membrane, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane
Pathways: Ciliopathies, Genes related to primary cilium development (based on CRISPR), Hedgehog signaling events mediated by Gli proteins, Metabolism of proteins, Post-translational protein modification, RAB geranylgeranylation
UniProt: Q9ULC3
Entrez ID: 51715
|
Does Knockout of LLPH in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
LLPH
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: LLPH (LLP homolog, long-term synaptic facilitation factor)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in dendrite extension and positive regulation of dendritic spine development. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: dendrite extension, positive regulation of dendritic spine development; MF: RNA binding, basal RNA polymerase II transcription machinery binding, protein binding; CC: chromosome, nucleolus, nucleus
Pathways:
UniProt: Q9BRT6
Entrez ID: 84298
|
Does Knockout of HSP90B1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
HSP90B1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: HSP90B1 (heat shock protein 90 beta family member 1)
Type: protein-coding
Summary: This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: ERAD pathway, actin rod assembly, cellular response to ATP, cellular response to manganese ion, negative regulation of apoptotic process, positive regulation of Wnt signaling pathway, positive regulation of toll-like receptor signaling pathway, protein folding, protein folding in endoplasmic reticulum, protein localization to plasma membrane, protein transport, response to endoplasmic reticulum stress, response to hypoxia, retrograde protein transport, ER to cytosol, sequestering of calcium ion; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, RNA binding, calcium ion binding, hydrolase activity, low-density lipoprotein particle receptor binding, nucleotide binding, protein binding, protein folding chaperone, protein phosphatase binding, protein phosphatase inhibitor activity, unfolded protein binding; CC: cytosol, endocytic vesicle lumen, endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, endoplasmic reticulum membrane, extracellular exosome, extracellular region, focal adhesion, melanosome, membrane, midbody, nucleus, perinuclear region of cytoplasm, protein-containing complex, sarcoplasmic reticulum, sarcoplasmic reticulum lumen, smooth endoplasmic reticulum, sperm plasma membrane
Pathways: ATF6 (ATF6-alpha) activates chaperone genes, ATF6 (ATF6-alpha) activates chaperones, AndrogenReceptor, Binding and Uptake of Ligands by Scavenger Receptors, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Estrogen signaling pathway - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, IL-17 signaling pathway - Homo sapiens (human), IL6-mediated signaling events, Immune System, Innate Immune System, Interleukin-4 and Interleukin-13 signaling, Lipid and atherosclerosis - Homo sapiens (human), Metabolism of proteins, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Photodynamic therapy-induced unfolded protein response, Post-translational protein modification, Post-translational protein phosphorylation, Prion disease pathway, Prostate cancer - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Salmonella infection - Homo sapiens (human), Scavenging by Class A Receptors, Signaling by Interleukins, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Thyroid hormone synthesis - Homo sapiens (human), Toll-like Receptor Cascades, Trafficking and processing of endosomal TLR, Unfolded Protein Response (UPR), Vesicle-mediated transport
UniProt: P14625
Entrez ID: 7184
|
Does Knockout of STEAP3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
STEAP3
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: STEAP3 (STEAP3 metalloreductase)
Type: protein-coding
Summary: This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: apoptotic process, copper ion import, iron ion transport, monoatomic ion transport, protein secretion; MF: FAD binding, cupric reductase (NADH) activity, ferric-chelate reductase (NADPH) activity, heme binding, identical protein binding, metal ion binding, oxidoreductase activity, protein binding; CC: cytoplasm, endosome, endosome membrane, membrane, multivesicular body, plasma membrane
Pathways: CDC42 GTPase cycle, Copper homeostasis, Direct p53 effectors, Ferroptosis, Ferroptosis - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, Iron metabolism in placenta, Iron uptake and transport, RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, RNA Polymerase II Transcription, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53, Transferrin endocytosis and recycling, Transport of small molecules, p53 signaling pathway - Homo sapiens (human)
UniProt: Q658P3
Entrez ID: 55240
|
Does Knockout of FRMD1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
FRMD1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: FRMD1 (FERM domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in positive regulation of hippo signaling. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasmic side of apical plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: Hippo signaling pathway - Homo sapiens (human), Hippo signaling pathway - multiple species - Homo sapiens (human)
UniProt: Q8N878
Entrez ID: 79981
|
Does Knockout of GOLGA8O in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
GOLGA8O
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GOLGA8O (golgin A8 family member O)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Golgi apparatus, Golgi cis cisterna, Golgi cisterna membrane, cis-Golgi network
Pathways:
UniProt: A6NCC3
Entrez ID: 728047
|
Does Knockout of NEB in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
NEB
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: NEB (nebulin)
Type: protein-coding
Summary: This gene encodes nebulin, a giant protein component of the cytoskeletal matrix that coexists with the thick and thin filaments within the sarcomeres of skeletal muscle. In most vertebrates, nebulin accounts for 3 to 4% of the total myofibrillar protein. The encoded protein contains approximately 30-amino acid long modules that can be classified into 7 types and other repeated modules. Protein isoform sizes vary from 600 to 800 kD due to alternative splicing that is tissue-, species-,and developmental stage-specific. Of the 183 exons in the nebulin gene, at least 43 are alternatively spliced, although exons 143 and 144 are not found in the same transcript. Of the several thousand transcript variants predicted for nebulin, the RefSeq Project has decided to create three representative RefSeq records. Mutations in this gene are associated with recessive nemaline myopathy. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cardiac muscle thin filament assembly, muscle organ development, regulation of actin filament length, somatic muscle development; MF: actin binding, actin filament binding, protein binding, structural constituent of muscle; CC: Z disc, actin cytoskeleton, contractile muscle fiber, cytoplasm, cytoskeleton, cytosol, extracellular exosome, myofibril, sarcomere
Pathways: Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Muscle contraction, Striated Muscle Contraction, Striated Muscle Contraction Pathway
UniProt: P20929
Entrez ID: 4703
|
Does Knockout of CNN1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
CNN1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CNN1 (calponin 1)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Involved in negative regulation of vascular associated smooth muscle cell proliferation. Located in cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin filament organization, actomyosin structure organization, negative regulation of vascular associated smooth muscle cell proliferation, regulation of smooth muscle contraction; MF: actin binding, actin filament binding, calmodulin binding, protein binding; CC: actin cytoskeleton, cytoskeleton, focal adhesion
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Developmental Lineage of Mammary Gland Myoepithelial Cells, Developmental Lineages of the Mammary Gland, Endothelin Pathways, Myometrial relaxation and contraction pathways
UniProt: P51911
Entrez ID: 1264
|
Does Knockout of NRBF2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
NRBF2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: NRBF2 (nuclear receptor binding factor 2)
Type: protein-coding
Summary: Involved in autophagy. Located in cytoplasm. Colocalizes with phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagy, response to endoplasmic reticulum stress; CC: autophagosome, cytoplasm, cytoplasmic vesicle, nucleoplasm, nucleus, phosphatidylinositol 3-kinase complex, class III
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Autophagy - animal - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Homo sapiens (human), Nuclear Receptor transcription pathway, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), RNA Polymerase II Transcription, Spinocerebellar ataxia - Homo sapiens (human)
UniProt: Q96F24
Entrez ID: 29982
|
Does Knockout of INTS3 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
INTS3
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: INTS3 (integrator complex subunit 3)
Type: protein-coding
Summary: The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016].
Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II transcription initiation surveillance, double-strand break repair via homologous recombination, mitotic G2/M transition checkpoint, regulation of transcription elongation by RNA polymerase II, response to ionizing radiation, snRNA processing; CC: INTAC complex, SOSS complex, cytoplasm, integrator complex, nucleoplasm, nucleus, site of double-strand break
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q68E01
Entrez ID: 65123
|
Does Knockout of MCM5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
MCM5
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MCM5 (minichromosome maintenance complex component 5)
Type: protein-coding
Summary: The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, DNA replication initiation, double-strand break repair via break-induced replication, regulation of DNA-templated DNA replication initiation; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA replication origin binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: CMG complex, MCM complex, chromosome, chromosome, telomeric region, membrane, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Ciliary landscape, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA strand elongation, Developmental Biology, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, TNFalpha, Unwinding of DNA, cdk regulation of dna replication
UniProt: P33992
Entrez ID: 4174
|
Does Knockout of ELP5 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
ELP5
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ELP5 (elongator acetyltransferase complex subunit 5)
Type: protein-coding
Summary: Predicted to contribute to tRNA binding activity. Predicted to be involved in positive regulation of cell migration and tRNA modification. Located in cytosol and nucleoplasm. Part of elongator holoenzyme complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of cell migration, regulation of translation, tRNA modification, tRNA processing, tRNA wobble uridine modification; MF: protein binding, tRNA binding; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q8TE02
Entrez ID: 23587
|
Does Knockout of MRPL33 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
MRPL33
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MRPL33 (mitochondrial ribosomal protein L33)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; CC: cytoplasm, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: O75394
Entrez ID: 9553
|
Does Knockout of INO80 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
INO80
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: INO80 (INO80 complex ATPase subunit)
Type: protein-coding
Summary: This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA recombination, DNA repair, DNA-templated transcription, UV-damage excision repair, cell division, cellular response to UV, cellular response to ionizing radiation, chromatin remodeling, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, mitotic sister chromatid segregation, positive regulation of DNA metabolic process, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of cell growth, positive regulation of nuclear cell cycle DNA replication, positive regulation of telomere maintenance in response to DNA damage, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, spindle assembly, telomere maintenance; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent chromatin remodeler activity, DNA binding, actin binding, alpha-tubulin binding, histone binding, hydrolase activity, nucleotide binding, protein binding; CC: Ino80 complex, chromosome, cytoplasm, cytoskeleton, cytosol, microtubule, nuclear body, nucleoplasm, nucleus, spindle
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q9ULG1
Entrez ID: 54617
|
Does Knockout of KLC2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
KLC2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: KLC2 (kinesin light chain 2)
Type: protein-coding
Summary: The protein encoded by this gene is a light chain of kinesin, a molecular motor responsible for moving vesicles and organelles along microtubules. Defects in this gene are a cause of spastic paraplegia, optic atrophy, and neuropathy (SPOAN) syndrome. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: lysosome localization, microtubule-based movement; MF: cadherin binding, kinesin binding, protein binding; CC: cytoplasm, cytoskeleton, cytosol, kinesin I complex, kinesin complex, lysosomal membrane, lysosome, membrane, microtubule, mitochondrion, nucleoplasm, plasma membrane, protein-containing complex
Pathways: Adaptive Immune System, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), RHO GTPase Effectors, RHO GTPases activate KTN1, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q9H0B6
Entrez ID: 64837
|
Does Knockout of ATP6V1G1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
ATP6V1G1
|
response to virus
|
Hepatoma Cell Line
|
Gene: ATP6V1G1 (ATPase H+ transporting V1 subunit G1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to increased oxygen levels, intracellular iron ion homeostasis, monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification; MF: ATP hydrolysis activity, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: ATPase complex, apical plasma membrane, cytosol, extracellular exosome, extrinsic component of synaptic vesicle membrane, lysosomal membrane, membrane, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Osteoclast Signaling, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, mTOR signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: O75348
Entrez ID: 9550
|
Does Knockout of GRIPAP1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
GRIPAP1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: GRIPAP1 (GRIP1 associated protein 1)
Type: protein-coding
Summary: This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: negative regulation of protein localization, negative regulation of receptor clustering, protein transport, regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane, regulation of recycling endosome localization within postsynapse; MF: guanyl-nucleotide exchange factor activity, identical protein binding, ionotropic glutamate receptor binding, protein binding; CC: axon, blood microparticle, cell projection, cytosol, dendrite, early endosome membrane, endosome, extrinsic component of postsynaptic early endosome membrane, glutamatergic synapse, membrane, neuronal cell body, nucleoplasm, presynaptic membrane, recycling endosome membrane, synapse
Pathways:
UniProt: Q4V328
Entrez ID: 56850
|
Does Knockout of HLA-DMB in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
HLA-DMB
|
cell proliferation
|
Melanoma Cell Line
|
Gene: HLA-DMB (major histocompatibility complex, class II, DM beta)
Type: protein-coding
Summary: HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MHC class II protein complex assembly, adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response, immune system process, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, positive regulation of T cell proliferation, positive regulation of immune response; MF: MHC class II protein complex binding, peptide antigen binding, protein binding; CC: MHC class II protein complex, endosome, late endosome membrane, lysosomal membrane, lysosome, membrane
Pathways: Adaptive Immune System, Allograft Rejection, Allograft rejection - Homo sapiens (human), Antigen processing and presentation - Homo sapiens (human), Asthma - Homo sapiens (human), Autoimmune thyroid disease - Homo sapiens (human), Cell adhesion molecules - Homo sapiens (human), Ebola Virus Pathway on Host, Epstein-Barr virus infection - Homo sapiens (human), Graft-versus-host disease - Homo sapiens (human), Hematopoietic cell lineage - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inflammatory bowel disease - Homo sapiens (human), Influenza A - Homo sapiens (human), Intestinal immune network for IgA production - Homo sapiens (human), Leishmaniasis - Homo sapiens (human), MHC class II antigen presentation, Phagosome - Homo sapiens (human), Rheumatoid arthritis - Homo sapiens (human), Staphylococcus aureus infection - Homo sapiens (human), Systemic lupus erythematosus - Homo sapiens (human), Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Toxoplasmosis - Homo sapiens (human), Tuberculosis - Homo sapiens (human), Type I diabetes mellitus - Homo sapiens (human), Viral myocarditis - Homo sapiens (human)
UniProt: P28068
Entrez ID: 3109
|
Does Knockout of TRAF4 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
TRAF4
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: TRAF4 (TNF receptor associated factor 4)
Type: protein-coding
Summary: This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, cell surface receptor signaling pathway, immune system process, innate immune response, positive regulation of JNK cascade, positive regulation of protein kinase activity, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of apoptotic process, regulation of canonical NF-kappaB signal transduction, respiratory gaseous exchange by respiratory system, respiratory tube development, signal transduction; MF: WW domain binding, enzyme binding, identical protein binding, metal ion binding, protein binding, protein kinase binding, signaling adaptor activity, thioesterase binding, transferase activity, tumor necrosis factor receptor binding, ubiquitin protein ligase binding, zinc ion binding; CC: anchoring junction, bicellular tight junction, cytoplasm, cytoskeleton, cytosol, fibrillar center, membrane, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: IL-17 signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), TNFalpha, Validated transcriptional targets of TAp63 isoforms, p53 transcriptional gene network
UniProt: Q9BUZ4
Entrez ID: 9618
|
Does Knockout of SIRPB2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
SIRPB2
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SIRPB2 (signal regulatory protein beta 2)
Type: protein-coding
Summary: Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q5JXA9
Entrez ID: 284759
|
Does Knockout of PLK1 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
PLK1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: PLK1 (polo like kinase 1)
Type: protein-coding
Summary: The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, Golgi inheritance, cell division, centrosome cycle, centrosome separation, double-strand break repair, double-strand break repair via alternative nonhomologous end joining, double-strand break repair via homologous recombination, establishment of mitotic spindle orientation, establishment of protein localization, female meiosis chromosome segregation, homologous chromosome segregation, metaphase/anaphase transition of mitotic cell cycle, microtubule bundle formation, mitotic G2 DNA damage checkpoint signaling, mitotic cell cycle, mitotic chromosome condensation, mitotic cytokinesis, mitotic nuclear membrane disassembly, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization, negative regulation of apoptotic process, negative regulation of double-strand break repair via homologous recombination, negative regulation of transcription by RNA polymerase II, nuclear division, nuclear membrane disassembly, peptidyl-serine phosphorylation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein localization to nucleus, positive regulation of proteolysis, positive regulation of ubiquitin protein ligase activity, positive regulation of ubiquitin-protein transferase activity, protein destabilization, protein localization to centrosome, protein localization to chromatin, protein localization to nuclear envelope, protein localization to organelle, protein localization to site of double-strand break, protein phosphorylation, protein ubiquitination, regulation of anaphase-promoting complex-dependent catabolic process, regulation of cell cycle, regulation of cell cycle process, regulation of cytokinesis, regulation of mitotic cell cycle, regulation of mitotic cell cycle phase transition, regulation of mitotic metaphase/anaphase transition, regulation of mitotic spindle assembly, regulation of protein localization to cell cortex, sister chromatid cohesion, synaptonemal complex disassembly; MF: ATP binding, anaphase-promoting complex binding, identical protein binding, kinase activity, magnesium ion binding, microtubule binding, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centriolar satellite, centriole, centrosome, chromatin, chromosome, chromosome, centromeric region, condensed chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, microtubule cytoskeleton, midbody, mitotic spindle pole, nucleoplasm, nucleus, outer kinetochore, spindle, spindle microtubule, spindle midzone, spindle pole, synaptonemal complex
Pathways: 22q11.2 copy number variation syndrome, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, ATR signaling pathway, AURKA Activation by TPX2, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NIMA Kinases NEK9, NEK6, NEK7, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Centrosome maturation, Cilium Assembly, Condensation of Prophase Chromosomes, Cyclin A/B1/B2 associated events during G2/M transition, Developmental Biology, EML4 and NUDC in mitotic spindle formation, FOXM1 transcription factor network, FoxO family signaling, FoxO signaling pathway - Homo sapiens (human), G2/M Transition, Golgi Cisternae Pericentriolar Stack Reorganization, Integrated Cancer Pathway, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Metaphase/Anaphase Transition, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Mitotic Telophase/Cytokinesis, Nuclear Envelope Breakdown, Oocyte meiosis - Homo sapiens (human), Organelle biogenesis and maintenance, PLK1 signaling events, Phosphorylation of Emi1, Phosphorylation of the APC/C, Polo-like kinase mediated events, Progesterone-mediated oocyte maturation - Homo sapiens (human), RHO GTPase Effectors, RHO GTPases Activate Formins, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of APC/C activators between G1/S and early anaphase, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation, Regulation of PLK1 Activity at G2/M Transition, Regulation of mitotic cell cycle, Regulation of toll-like receptor signaling pathway, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TNF-alpha signaling pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Validated transcriptional targets of TAp63 isoforms, p73 transcription factor network
UniProt: P53350
Entrez ID: 5347
|
Does Knockout of RPL15 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
RPL15
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: RPL15 (ribosomal protein L15)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, cadherin binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleus, ribonucleoprotein complex, ribosomal subunit, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P61313
Entrez ID: 6138
|
Does Knockout of SOS1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
SOS1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)
Type: protein-coding
Summary: This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell homeostasis, B cell receptor signaling pathway, Fc-epsilon receptor signaling pathway, Ras protein signal transduction, Schwann cell development, T cell activation, axon guidance, blood vessel morphogenesis, cardiac atrium morphogenesis, cytokine-mediated signaling pathway, epidermal growth factor receptor signaling pathway, eyelid development in camera-type eye, fibroblast growth factor receptor signaling pathway, hair follicle development, heart morphogenesis, heart trabecula morphogenesis, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, leukocyte migration, lymphocyte homeostasis, midbrain morphogenesis, multicellular organism growth, myelination, neurotrophin TRK receptor signaling pathway, pericardium morphogenesis, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of small GTPase mediated signal transduction, regulation of T cell differentiation in thymus, regulation of T cell proliferation, regulation of cell population proliferation, regulation of pro-B cell differentiation, regulation of transcription by RNA polymerase II, response to ischemia, roof of mouth development, signal transduction, small GTPase-mediated signal transduction, vitellogenesis; MF: GTPase activator activity, SH3 domain binding, epidermal growth factor receptor binding, guanyl-nucleotide exchange factor activity, molecular condensate scaffold activity, protein binding, protein heterodimerization activity, protein kinase binding; CC: GTPase complex, cytoplasm, cytosol, glutamatergic synapse, neuronal cell body, plasma membrane, postsynaptic density
Pathways: Activated NTRK2 signals through FRS2 and FRS3, Activated NTRK2 signals through RAS, Activated NTRK3 signals through RAS, Activation of RAC1, Acute myeloid leukemia - Homo sapiens (human), Acute viral myocarditis, Adaptive Immune System, Alcoholism - Homo sapiens (human), Alpha 6 Beta 4 signaling pathway, Angiopoietin Like Protein 8 Regulatory Pathway, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Axon guidance, B Cell Receptor Signaling Pathway, B cell receptor signaling pathway - Homo sapiens (human), BCR, BCR signaling pathway, BDNF-TrkB Signaling, Breast cancer - Homo sapiens (human), Breast cancer pathway, Cell death signalling via NRAGE, NRIF and NADE, Cell surface interactions at the vascular wall, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Choline metabolism in cancer - Homo sapiens (human), Chronic myeloid leukemia - Homo sapiens (human), Colorectal cancer - Homo sapiens (human), Constitutive Signaling by EGFRvIII, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Constitutive Signaling by Overexpressed ERBB2, Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, DNA damage response (only ATM dependent), Death Receptor Signaling, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downstream signal transduction, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, EGF-EGFR signaling pathway, EGFR Transactivation by Gastrin, EGFR Tyrosine Kinase Inhibitor Resistance, EGFR-dependent Endothelin signaling events, EGFR1, EPO Receptor Signaling, EPO signaling pathway, ESC Pluripotency Pathways, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Envelope proteins and their potential roles in EDMD physiopathology, Epithelial to mesenchymal transition in colorectal cancer, ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), ErbB1 downstream signaling, ErbB2/ErbB3 signaling events, Erythropoietin activates RAS, Estrogen signaling pathway - Homo sapiens (human), FCERI mediated Ca+2 mobilization, FCERI mediated MAPK activation, FGF signaling pathway, FLT3 Signaling, FLT3 signaling in disease, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), Fc epsilon receptor (FCERI) signaling, Fc-epsilon receptor I signaling in mast cells, Fibroblast growth factor-1, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), FoxO signaling pathway - Homo sapiens (human), Fragile X Syndrome, G alpha (12/13) signalling events, G alpha (q) signalling events, GMCSF-mediated signaling events, GPCR downstream signalling, GRB2 events in EGFR signaling, GRB2 events in ERBB2 signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , Gap junction - Homo sapiens (human), Gastric cancer - Homo sapiens (human), Gastrin signaling pathway, Gastrin-CREB signalling pathway via PKC and MAPK, Glioma - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hemostasis, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Hepatitis C and Hepatocellular Carcinoma, Hepatocellular carcinoma - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IGF1 pathway, IGF1R signaling cascade, IL-2 signaling pathway, IL-3 signaling pathway, IL-4 signaling pathway, IL-5 signaling pathway, IL-6 signaling pathway, IL2, IL2 signaling events mediated by PI3K, IL2 signaling events mediated by STAT5, IL2-mediated signaling events, IL5, IL6, IL6-mediated signaling events, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Infectious disease, Innate Immune System, Insulin Pathway, Insulin Signaling, Insulin Signalling, Insulin receptor signalling cascade, Insulin signaling pathway - Homo sapiens (human), Integrin signaling, Integrin-mediated Cell Adhesion, Interleukin receptor SHC signaling, Interleukin-15 signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Internalization of ErbB1, JAK-STAT signaling pathway - Homo sapiens (human), Kit receptor signaling pathway, KitReceptor, Leptin signaling pathway, MAPK Cascade, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK pathway in congenital thyroid cancer, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, MET activates RAS signaling, Melanoma, MicroRNAs in cancer - Homo sapiens (human), NCAM signaling for neurite out-growth, NRAGE signals death through JNK, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Nervous system development, Neurotrophic factor-mediated Trk receptor signaling, Neurotrophin signaling pathway - Homo sapiens (human), Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Oncostatin M Signaling Pathway, Oncostatin_M, PDGFR-alpha signaling pathway, PDGFR-beta signaling pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Pilocytic astrocytoma, Plasma membrane estrogen receptor signaling, Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Potential therapeutics for SARS, Prolactin Signaling Pathway, Prolactin signaling pathway - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAC1 GTPase cycle, RAC1-PAK1-p38-MMP2 Pathway, RAF/MAP kinase cascade, RET signaling, RHO GTPase cycle, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of KIT signaling, Regulation of RAC1 activity, Regulation of Ras family activation, Regulation of actin cytoskeleton - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), Role of LAT2/NTAL/LAB on calcium mobilization, SARS-CoV Infections, SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, SHC-related events triggered by IGF1R, SHC1 events in EGFR signaling, SHC1 events in ERBB2 signaling, SHC1 events in ERBB4 signaling, SHP2 signaling, SOS-mediated signalling, Signal Transduction, Signal attenuation, Signaling by CSF1 (M-CSF) in myeloid cells, Signaling by EGFR, Signaling by EGFR in Cancer, Signaling by EGFRvIII in Cancer, Signaling by ERBB2, Signaling by ERBB2 ECD mutants, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 TMD/JMD mutants, Signaling by ERBB2 in Cancer, Signaling by ERBB4, Signaling by Erythropoietin, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR1, Signaling by FGFR1 in disease, Signaling by FGFR2, Signaling by FGFR2 in disease, Signaling by FGFR3, Signaling by FGFR3 in disease, Signaling by FGFR4, Signaling by FGFR4 in disease, Signaling by FLT3 ITD and TKD mutants, Signaling by FLT3 fusion proteins, Signaling by GPCR, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by KIT in disease, Signaling by LTK, Signaling by Ligand-Responsive EGFR Variants in Cancer, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRK2 (TRKB), Signaling by NTRK3 (TRKC), Signaling by NTRKs, Signaling by PDGF, Signaling by PDGFR in disease, Signaling by PDGFRA extracellular domain mutants, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants, Signaling by the B Cell Receptor (BCR), Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by Stem cell factor receptor (c-Kit), Signaling events mediated by TCPTP, Signaling events mediated by focal adhesion kinase, Signaling events regulated by Ret tyrosine kinase, Signaling of Hepatocyte Growth Factor Receptor, Signalling to ERKs, Signalling to RAS, T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, T-cell receptor (TCR) signaling pathway, TCR, TCR signaling in naïve CD4+ T cells, TCR signaling in naïve CD8+ T cells, TGF-beta Signaling Pathway, TGF-beta receptor signaling, TNF-alpha signaling pathway, TNFalpha, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, Tie2 Signaling, Trk receptor signaling mediated by PI3K and PLC-gamma, VEGFR3 signaling in lymphatic endothelium, Viral Infection Pathways, angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling, bcr signaling pathway, bioactive peptide induced signaling pathway, calcium signaling by hbx of hepatitis b virus, egf signaling pathway, epo signaling pathway, erk1/erk2 mapk signaling pathway, fc epsilon receptor i signaling in mast cells, growth hormone signaling pathway, igf-1 signaling pathway, il 2 signaling pathway, il 3 signaling pathway, il 6 signaling pathway, il-2 receptor beta chain in t cell activation, inhibition of cellular proliferation by gleevec, insulin signaling pathway, integrin signaling pathway, keratinocyte differentiation, links between pyk2 and map kinases, mTOR signaling pathway - Homo sapiens (human), map kinase inactivation of smrt corepressor, mcalpain and friends in cell motility, multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation, nerve growth factor pathway (ngf), nfat and hypertrophy of the heart , p75 NTR receptor-mediated signalling, pdgf signaling pathway, phospholipids as signalling intermediaries, phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway, pten dependent cell cycle arrest and apoptosis, ras signaling pathway, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, role of erbb2 in signal transduction and oncology, role of erk5 in neuronal survival pathway, sprouty regulation of tyrosine kinase signals, t cell receptor signaling pathway, the igf-1 receptor and longevity, tpo signaling pathway, transcription factor creb and its extracellular signals, trefoil factors initiate mucosal healing, trka receptor signaling pathway, vegf hypoxia and angiogenesis
UniProt: Q07889
Entrez ID: 6654
|
Does Knockout of PIGR in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
PIGR
|
cell proliferation
|
Bladder Carcinoma
|
Gene: PIGR (polymeric immunoglobulin receptor)
Type: protein-coding
Summary: This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009].
Gene Ontology: BP: Fc receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, epidermal growth factor receptor signaling pathway, immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor, receptor clustering, signal transduction; MF: polymeric immunoglobulin binding, polymeric immunoglobulin receptor activity, transmembrane signaling receptor activity; CC: azurophil granule membrane, bounding membrane of organelle, cytoplasmic vesicle membrane, endomembrane system, extracellular exosome, extracellular region, extracellular space, membrane, plasma membrane, receptor complex, secretory IgA immunoglobulin complex
Pathways: IL4-mediated signaling events, Immune System, Innate Immune System, Intestinal immune network for IgA production - Homo sapiens (human), Neutrophil degranulation
UniProt: P01833
Entrez ID: 5284
|
Does Knockout of HDAC3 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
HDAC3
|
cell proliferation
|
Cancer Cell Line
|
Gene: HDAC3 (histone deacetylase 3)
Type: protein-coding
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA repair-dependent chromatin remodeling, cellular response to fluid shear stress, cellular response to mechanical stimulus, cellular response to parathyroid hormone stimulus, chromatin organization, circadian regulation of gene expression, cornified envelope assembly, epidermis development, epigenetic regulation of gene expression, establishment of mitotic spindle orientation, establishment of skin barrier, gene expression, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of JNK cascade, negative regulation of apoptotic process, negative regulation of cardiac muscle cell differentiation, negative regulation of ferroptosis, negative regulation of interleukin-1 production, negative regulation of myotube differentiation, negative regulation of protein export from nucleus, negative regulation of transcription by RNA polymerase II, negative regulation of tumor necrosis factor production, neural precursor cell proliferation, positive regulation of TOR signaling, positive regulation of cold-induced thermogenesis, positive regulation of ferroptosis, positive regulation of neuron apoptotic process, positive regulation of protein import into nucleus, positive regulation of protein phosphorylation, positive regulation of protein ubiquitination, positive regulation of transcription by RNA polymerase II, positive regulation of type B pancreatic cell apoptotic process, protein deacetylation, protein modification process, random inactivation of X chromosome, regulation of circadian rhythm, regulation of mitotic cell cycle, regulation of multicellular organism growth, regulation of protein stability, response to dexamethasone, response to nutrient levels, response to xenobiotic stimulus, rhythmic process, spindle assembly, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor binding, GTPase binding, NF-kappaB binding, chromatin DNA binding, chromatin binding, cyclin binding, deacetylase activity, enzyme binding, histone deacetylase activity, histone deacetylase activity, hydrolytic mechanism, histone deacetylase binding, histone decrotonylase activity, hydrolase activity, protein binding, protein de-2-hydroxyisobutyrylase activity, protein decrotonylase activity, protein lysine deacetylase activity, protein lysine delactylase activity, transcription corepressor activity, transcription corepressor binding, ubiquitin-specific protease binding; CC: Golgi apparatus, chromatin, chromosome, cytoplasm, cytosol, histone deacetylase complex, mitotic spindle, nucleoplasm, nucleus, plasma membrane, transcription repressor complex
Pathways: 16p11.2 proximal deletion syndrome, 22q11.2 copy number variation syndrome, Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Adipogenesis, Alcoholism - Homo sapiens (human), Association of TriC/CCT with target proteins during biosynthesis, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chaperonin-mediated protein folding, Chromatin modifying enzymes, Chromatin organization, Circadian clock, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Cytoprotection by HMOX1, Death Receptor Signaling, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of Developmental Biology, Disorders of Nervous System Development, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Ethanol effects on histone modifications, Expression of BMAL (ARNTL), CLOCK, and NPAS2, Gene expression (Transcription), Generic Transcription Pathway, HCMV Early Events, HCMV Infection, HDACs deacetylate histones, Heme signaling, IL-18 signaling pathway, Infectious disease, Initiation of transcription and translation elongation at the HIV-1 LTR, Intracellular signaling by second messengers, Loss of MECP2 binding ability to the NCoR/SMRT complex, Loss of function of MECP2 in Rett syndrome, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, Metabolism of proteins, Mitochondrial biogenesis, NOTCH1 Intracellular Domain Regulates Transcription, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Neural Crest Differentiation, Neutrophil extracellular trap formation - Homo sapiens (human), Notch-HLH transcription pathway, Organelle biogenesis and maintenance, PIP3 activates AKT signaling, PPARA activates gene expression, PTEN Regulation, Pervasive developmental disorders, Protein folding, RNA Polymerase II Transcription, RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression, RUNX2 regulates bone development, RUNX2 regulates osteoblast differentiation, Regulation of MECP2 expression and activity, Regulation of PTEN gene transcription, Regulation of lipid metabolism by PPARalpha, Regulation of retinoblastoma protein, Retinoic acid receptors-mediated signaling, STAT3 nuclear events downstream of ALK signaling, Signal Transduction, Signaling by ALK, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Thyroid hormone signaling pathway - Homo sapiens (human), Transcription co-factors SKI and SKIL protein partners, Transcriptional Regulation by MECP2, Transcriptional activation of mitochondrial biogenesis, Transcriptional regulation by RUNX2, Transcriptional regulation of white adipocyte differentiation, Validated targets of C-MYC transcriptional repression, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), acetylation and deacetylation of rela in nucleus, nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells, p75 NTR receptor-mediated signalling, p75NTR negatively regulates cell cycle via SC1
UniProt: O15379
Entrez ID: 8841
|
Does Knockout of JADE2 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
JADE2
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: JADE2 (jade family PHD finger 2)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Involved in histone acetylation. Located in nucleoplasm. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin remodeling, protein ubiquitination, regulation of DNA biosynthetic process, regulation of DNA replication, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell growth, regulation of transcription by RNA polymerase II; MF: histone H3K14 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: extracellular exosome, histone acetyltransferase complex, nucleoplasm
Pathways:
UniProt: Q9NQC1
Entrez ID: 23338
|
Does Knockout of DDN in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
DDN
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: DDN (dendrin)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in cell projection and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding; CC: cell projection, cytoplasm, dendrite, dendritic spine membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus, perikaryon, plasma membrane, postsynapse, postsynaptic membrane, presynapse, synapse
Pathways:
UniProt: O94850
Entrez ID: 23109
|
Does Knockout of SGO2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
SGO2
|
cell proliferation
|
Cancer Cell Line
|
Gene: SGO2 (shugoshin 2)
Type: protein-coding
Summary: Predicted to be involved in homologous chromosome segregation; meiotic sister chromatid cohesion; and mitotic sister chromatid segregation. Predicted to act upstream of or within meiotic nuclear division; positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; and protein localization. Located in chromosome, centromeric region and nuclear body. Part of mitotic cohesin complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, chromosome segregation, meiotic cell cycle, meiotic sister chromatid cohesion; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, mitotic cohesin complex, nuclear body, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q562F6
Entrez ID: 151246
|
Does Knockout of TTC14 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
TTC14
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: TTC14 (tetratricopeptide repeat domain 14)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: Ectoderm Differentiation
UniProt: Q96N46
Entrez ID: 151613
|
Does Knockout of SCGB3A2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
SCGB3A2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SCGB3A2 (secretoglobin family 3A member 2)
Type: protein-coding
Summary: The protein encoded by this gene is a secreted lung surfactant protein and a downstream target of thyroid transcription factor. A single nucleotide polymorphism in the promoter of this gene results in susceptibility to asthma.[provided by RefSeq, Mar 2010].
Gene Ontology: CC: endocytic vesicle lumen, extracellular region, extracellular space
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, Scavenging by Class A Receptors, Vesicle-mediated transport
UniProt: Q96PL1
Entrez ID: 117156
|
Does Knockout of EXOSC9 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
EXOSC9
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: EXOSC9 (exosome component 9)
Type: protein-coding
Summary: This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, U1 snRNA 3'-end processing, U4 snRNA 3'-end processing, U5 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), immune response, mRNA catabolic process, nuclear mRNA surveillance, nuclear polyadenylation-dependent rRNA catabolic process, nuclear-transcribed mRNA catabolic process, positive regulation of cell growth, positive regulation of transcription by RNA polymerase II, rRNA catabolic process, rRNA processing; MF: 3'-5'-RNA exonuclease activity, RNA binding, RNA exonuclease activity, RNA polymerase II-specific DNA-binding transcription factor binding, mRNA 3'-UTR AU-rich region binding, protein binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, exoribonuclease complex, exosome (RNase complex), extracellular exosome, nuclear chromosome, nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, PERK regulates gene expression, RNA degradation - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, Unfolded Protein Response (UPR), mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q06265
Entrez ID: 5393
|
Does Knockout of INPP5B in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
INPP5B
|
cell proliferation
|
Cancer Cell Line
|
Gene: INPP5B (inositol polyphosphate-5-phosphatase B)
Type: protein-coding
Summary: This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: flagellated sperm motility, in utero embryonic development, inositol phosphate metabolic process, lipid metabolic process, phosphatidylinositol dephosphorylation, regulation of protein processing, signal transduction, spermatogenesis; MF: hydrolase activity, inositol phosphate phosphatase activity, inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity, metal ion binding, phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, protein binding; CC: Golgi apparatus, cytoplasm, cytoplasmic vesicle, cytosol, early endosome membrane, endoplasmic reticulum-Golgi intermediate compartment, endosome, membrane, neuron projection, phagocytic vesicle membrane, plasma membrane
Pathways: 1D-<i>myo</i>-inositol hexakisphosphate biosynthesis II (mammalian), 3-phosphoinositide degradation, D-<i>myo</i>-inositol (1,3,4)-trisphosphate biosynthesis, D-<i>myo</i>-inositol (1,4,5)-trisphosphate degradation, Inositol phosphate metabolism, Inositol phosphate metabolism - Homo sapiens (human), Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Synthesis of IP2, IP, and Ins in the cytosol, Synthesis of IP3 and IP4 in the cytosol, superpathway of D-<i>myo</i>-inositol (1,4,5)-trisphosphate metabolism, superpathway of inositol phosphate compounds
UniProt: P32019
Entrez ID: 3633
|
Does Knockout of PCP2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
PCP2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PCP2 (Purkinje cell protein 2)
Type: protein-coding
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within rhodopsin mediated signaling pathway. Predicted to be located in neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase regulator activity, guanyl-nucleotide exchange factor activity, protein binding
Pathways: G alpha (i) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: Q8IVA1
Entrez ID: 126006
|
Does Knockout of COPZ1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
COPZ1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: COPZ1 (coat protein complex I subunit zeta 1)
Type: protein-coding
Summary: This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: intra-Golgi vesicle-mediated transport, intracellular protein transport, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; CC: COPI vesicle coat, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum membrane, membrane, membrane coat, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P61923
Entrez ID: 22818
|
Does Knockout of RAD51AP1 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
RAD51AP1
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: RAD51AP1 (RAD51 associated protein 1)
Type: protein-coding
Summary: Enables nucleic acid binding activity. Involved in DNA repair; cellular response to ionizing radiation; and positive regulation of DNA recombination. Located in chromatin and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cellular response to ionizing radiation, double-strand break repair via homologous recombination, interstrand cross-link repair, meiotic cell cycle, positive regulation of double-strand break repair via homologous recombination, positive regulation of reciprocal meiotic recombination, regulation of double-strand break repair via homologous recombination; MF: D-loop DNA binding, DNA binding, DNA secondary structure binding, RNA binding, double-stranded DNA binding, protein binding, single-stranded DNA binding; CC: chromatin, chromosome, chromosome, telomeric region, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q96B01
Entrez ID: 10635
|
Does Knockout of ARMC7 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
ARMC7
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: ARMC7 (armadillo repeat containing 7)
Type: protein-coding
Summary: Predicted to be involved in RNA splicing and mRNA processing. Predicted to be part of spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, mRNA processing
Pathways:
UniProt: Q9H6L4
Entrez ID: 79637
|
Does Knockout of PTPN12 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
PTPN12
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PTPN12 (protein tyrosine phosphatase non-receptor type 12)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: cellular response to epidermal growth factor stimulus, negative regulation of ERBB signaling pathway, negative regulation of platelet-derived growth factor receptor-beta signaling pathway, peptidyl-tyrosine dephosphorylation, protein dephosphorylation, regulation of epidermal growth factor receptor signaling pathway, tissue regeneration; MF: SH3 domain binding, hydrolase activity, non-membrane spanning protein tyrosine phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein tyrosine phosphatase activity; CC: anchoring junction, cell projection, cytoplasm, cytosol, focal adhesion, nucleoplasm, nucleus, podosome
Pathways: Constitutive Signaling by Overexpressed ERBB2, Cytokine Signaling in Immune system, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downregulation of ERBB2 signaling, EGF-EGFR signaling pathway, EGFR downregulation, EGFR1, Immune System, Interleukin-1 family signaling, Interleukin-37 signaling, SHC1 events in ERBB2 signaling, Signal Transduction, Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB2 in Cancer, Signaling by Interleukins, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, TCR
UniProt: Q05209
Entrez ID: 5782
|
Does Knockout of MAP7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
MAP7
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: MAP7 (microtubule associated protein 7)
Type: protein-coding
Summary: The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. Microtubule-associated proteins are thought to be involved in microtubule dynamics, which is essential for cell polarization and differentiation. This protein has been shown to be able to stabilize microtubules, and may serve to modulate microtubule functions. Studies of the related mouse protein also suggested an essential role in microtubule function required for spermatogenesis. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
Gene Ontology: BP: establishment or maintenance of cell polarity, microtubule cytoskeleton organization, protein localization to plasma membrane, response to osmotic stress; MF: protein binding, signaling receptor binding, structural molecule activity; CC: axon, basolateral plasma membrane, cytoplasm, cytoskeleton, cytosol, membrane, microtubule, microtubule associated complex, microtubule cytoskeleton, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q14244
Entrez ID: 9053
|
Does Knockout of NHP2 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
NHP2
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: NHP2 (NHP2 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: rRNA processing, rRNA pseudouridine synthesis, ribosome biogenesis, snRNA pseudouridine synthesis, snoRNA guided rRNA pseudouridine synthesis, telomerase RNA localization to Cajal body, telomere maintenance via telomerase; MF: RNA binding, U3 snoRNA binding, box H/ACA snoRNA binding, mRNA 3'-UTR binding, protein binding, telomerase RNA binding; CC: Cajal body, box H/ACA scaRNP complex, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, chromosome, telomeric region, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Telomere Extension By Telomerase, Telomere Maintenance, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NX24
Entrez ID: 55651
|
Does Knockout of ANKRD1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
ANKRD1
|
cell proliferation
|
Cancer Cell Line
|
Gene: ANKRD1 (ankyrin repeat domain 1)
Type: protein-coding
Summary: The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cardiac muscle tissue morphogenesis, cellular response to hypoxia, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to mechanical stimulus, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, cellular response to xenobiotic stimulus, negative regulation of DNA biosynthetic process, negative regulation of transcription by RNA polymerase II, phospholipase C/protein kinase C signal transduction, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of neuron projection development, positive regulation of protein secretion, regulation of transcription by RNA polymerase II, response to muscle stretch, sarcomere organization, skeletal muscle cell differentiation; MF: DNA binding, R-SMAD binding, RNA polymerase II-specific DNA-binding transcription factor binding, histone deacetylase binding, p53 binding, protein binding, titin binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity; CC: I band, cytoplasm, cytosol, fibrillar center, myofibril, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: Glucocorticoid Receptor Pathway, Hypertrophy Model, Metabolism, Metabolism of lipids, Nuclear Receptors Meta-Pathway, PPARA activates gene expression, Regulation of lipid metabolism by PPARalpha
UniProt: Q15327
Entrez ID: 27063
|
Does Knockout of RPL28 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
RPL28
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPL28 (ribosomal protein L28)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cell body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, dendrite, extracellular exosome, membrane, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46779
Entrez ID: 6158
|
Does Knockout of LAMTOR3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
LAMTOR3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3)
Type: protein-coding
Summary: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: TORC1 signaling, cellular response to amino acid stimulus, intracellular protein localization, positive regulation of MAPK cascade, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of intracellular signal transduction, protein localization to cell junction, regulation of TOR signaling; MF: guanyl-nucleotide exchange factor activity, kinase activator activity, molecular adaptor activity, protein binding; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, cytoplasm, endosome, endosome membrane, extracellular exosome, focal adhesion, late endosome, late endosome membrane, lysosomal membrane, membrane, plasma membrane, specific granule membrane, tertiary granule membrane
Pathways: Amino acids regulate mTORC1, Autophagy, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gastrin signaling pathway, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Intracellular signaling by second messengers, MAP2K and MAPK activation, MAPK Cascade, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, MTOR signalling, Macroautophagy, Melanoma, Neutrophil degranulation, PIP3 activates AKT signaling, PTEN Regulation, RAF/MAP kinase cascade, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Homo sapiens (human), mTORC1-mediated signalling
UniProt: Q9UHA4
Entrez ID: 8649
|
Does Knockout of SNRPB in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
SNRPB
|
cell proliferation
|
Melanoma Cell Line
|
Gene: SNRPB (small nuclear ribonucleoprotein polypeptides B and B1)
Type: protein-coding
Summary: The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 7-methylguanosine cap hypermethylation, RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, protein methylation, spliceosomal snRNP assembly; MF: RNA binding, U1 snRNP binding, U2 snRNP binding, histone pre-mRNA DCP binding, protein binding, snRNP binding, telomerase RNA binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type prespliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, cytoplasm, cytosol, histone pre-mRNA 3'end processing complex, methylosome, nucleoplasm, nucleus, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex, telomerase holoenzyme complex
Pathways: Spliceosome - Homo sapiens (human), Systemic lupus erythematosus - Homo sapiens (human), mRNA Processing
UniProt: P14678
Entrez ID: 6628
|
Does Knockout of SDHD in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
SDHD
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SDHD (succinate dehydrogenase complex subunit D)
Type: protein-coding
Summary: This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: cellular response to hypoxia, mitochondrial electron transport, succinate to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, regulation of catecholamine secretion, tricarboxylic acid cycle; MF: electron transfer activity, heme binding, metal ion binding, protein binding, succinate dehydrogenase (quinone) activity, ubiquinone binding; CC: membrane, mitochondrial envelope, mitochondrial inner membrane, mitochondrion, respiratory chain complex II (succinate dehydrogenase)
Pathways: 2-ketoglutarate dehydrogenase complex deficiency, Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Citrate cycle (TCA cycle) - Homo sapiens (human), Citric Acid Cycle, Citric acid cycle (TCA cycle), Congenital lactic acidosis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Fumarase deficiency, Glutaminolysis and Cancer, Huntington disease - Homo sapiens (human), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial CII Assembly, Mitochondrial Electron Transport Chain, Mitochondrial complex II deficiency, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Pyruvate dehydrogenase deficiency (E2), Pyruvate dehydrogenase deficiency (E3), Respiratory electron transport, TCA Cycle (aka Krebs or citric acid cycle), TCA cycle, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate, Thermogenesis - Homo sapiens (human), Warburg Effect, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: O14521
Entrez ID: 6392
|
Does Knockout of CD2BP2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
CD2BP2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: CD2BP2 (CD2 cytoplasmic tail binding protein 2)
Type: protein-coding
Summary: This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008].
Gene Ontology: BP: RNA splicing, mRNA processing, spliceosomal tri-snRNP complex assembly; MF: protein binding, ribonucleoprotein complex binding; CC: U4/U6 x U5 tri-snRNP complex, U5 snRNP, cytoplasm, cytosol, fibrillar center, nuclear speck, nucleoplasm, nucleus
Pathways: Ciliary landscape, mRNA Processing
UniProt: O95400
Entrez ID: 10421
|
Does Knockout of METTL22 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
METTL22
|
cell proliferation
|
Melanoma Cell Line
|
Gene: METTL22 (methyltransferase 22, Kin17 lysine)
Type: protein-coding
Summary: This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: methylation, protein methylation; MF: heat shock protein binding, methyltransferase activity, protein binding, protein methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity; CC: nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Protein methylation
UniProt: Q9BUU2
Entrez ID: 79091
|
Does Knockout of TAS2R14 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
TAS2R14
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: TAS2R14 (taste 2 receptor member 14)
Type: protein-coding
Summary: This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane, plasma membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Signal Transduction, Signaling by GPCR, Taste transduction - Homo sapiens (human)
UniProt: Q9NYV8
Entrez ID: 50840
|
Does Knockout of PTAFR in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
PTAFR
|
response to virus
|
Huh-7 Cell
|
Gene: PTAFR (platelet activating factor receptor)
Type: protein-coding
Summary: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: G protein-coupled purinergic nucleotide receptor signaling pathway, G protein-coupled receptor signaling pathway, chemotaxis, immune response, inflammatory response, inositol trisphosphate biosynthetic process, lipopolysaccharide-mediated signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, response to lipopolysaccharide, signal transduction; MF: G protein-coupled purinergic nucleotide receptor activity, G protein-coupled receptor activity, lipopolysaccharide binding, lipopolysaccharide immune receptor activity, phospholipid binding, platelet activating factor receptor activity, protein binding; CC: membrane, plasma membrane, secretory granule membrane, tertiary granule membrane
Pathways: Calcium signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Cytokine Signaling in Immune system, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Immune System, Innate Immune System, Interferon Signaling, Interferon gamma signaling, Interleukin-10 signaling, Neuroactive ligand-receptor interaction - Homo sapiens (human), Neutrophil degranulation, Signal Transduction, Signaling by GPCR, Signaling by Interleukins, Small Ligand GPCRs, Staphylococcus aureus infection - Homo sapiens (human)
UniProt: P25105
Entrez ID: 5724
|
Does Knockout of PRRG2 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
PRRG2
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: PRRG2 (proline rich and Gla domain 2)
Type: protein-coding
Summary: The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: blood coagulation, proteolysis; MF: calcium ion binding, protein binding, serine-type endopeptidase activity; CC: extracellular region, extracellular space, membrane, plasma membrane
Pathways:
UniProt: O14669
Entrez ID: 5639
|
Does Knockout of PANK3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
PANK3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PANK3 (pantothenate kinase 3)
Type: protein-coding
Summary: This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: coenzyme A biosynthetic process, phosphorylation; MF: ATP binding, acetyl-CoA binding, kinase activity, nucleotide binding, pantothenate kinase activity, protein homodimerization activity, transferase activity, vitamin binding; CC: cytoplasm, cytosol, nucleus
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA biosynthesis - Homo sapiens (human), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q9H999
Entrez ID: 79646
|
Does Knockout of PPP1R8 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
PPP1R8
|
cell proliferation
|
Bladder Carcinoma
|
Gene: PPP1R8 (protein phosphatase 1 regulatory subunit 8)
Type: protein-coding
Summary: This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA catabolic process, RNA splicing, cell population proliferation, mRNA processing; MF: DNA binding, RNA binding, RNA endonuclease activity, endonuclease activity, hydrolase activity, mRNA binding, molecular function inhibitor activity, nuclease activity, protein binding, protein phosphatase inhibitor activity, protein phosphatase regulator activity, protein serine/threonine phosphatase inhibitor activity, ribonuclease E activity; CC: cytoplasm, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways:
UniProt: Q12972
Entrez ID: 5511
|
Does Knockout of CHMP7 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
CHMP7
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CHMP7 (charged multivesicular body protein 7)
Type: protein-coding
Summary: Involved in several processes, including late endosome to vacuole transport; midbody abscission; and mitotic nuclear division. Located in cytosol; nuclear envelope; and nucleoplasm. Part of ESCRT III complex. Colocalizes with chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ESCRT III complex disassembly, autophagosome maturation, autophagy, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport, late endosome to vacuole transport via multivesicular body sorting pathway, membrane fission, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein localization to chromatin, protein transport, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, chromatin, cytoplasm, cytoplasmic side of plasma membrane, cytosol, kinetochore, kinetochore microtubule, lysosomal membrane, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleoplasm, nucleus, plasma membrane
Pathways: Autophagy, Budding and maturation of HIV virion, Cell Cycle, Cell Cycle, Mitotic, Disease, Early SARS-CoV-2 Infection Events, Endocytosis - Homo sapiens (human), Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Infectious disease, Late Phase of HIV Life Cycle, Late endosomal microautophagy, M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Homo sapiens (human), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Sealing of the nuclear envelope (NE) by ESCRT-III, Translation of Replicase and Assembly of the Replication Transcription Complex, Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q8WUX9
Entrez ID: 91782
|
Does Knockout of ELOC in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
ELOC
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ELOC (elongin C)
Type: protein-coding
Summary: This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011].
Gene Ontology: BP: protein ubiquitination, regulation of transcription by RNA polymerase II, target-directed miRNA degradation, transcription initiation at RNA polymerase II promoter, ubiquitin-dependent protein catabolic process; MF: protein binding, protein-macromolecule adaptor activity, transcription corepressor binding; CC: Cul2-RING ubiquitin ligase complex, Cul5-RING ubiquitin ligase complex, cytoplasm, cytosol, elongin complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Dual hijack model of Vif in HIV infection, HIF-1 signaling pathway - Homo sapiens (human), HIF-2-alpha transcription factor network, Hijack of ubiquitination by SARS-CoV-2, Human immunodeficiency virus 1 infection - Homo sapiens (human), Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, Pathways in cancer - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), Type 2 papillary renal cell carcinoma, Ubiquitin mediated proteolysis - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway
UniProt: Q15369
Entrez ID: 6921
|
Does Knockout of HSPA2 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
HSPA2
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: HSPA2 (heat shock protein family A (Hsp70) member 2)
Type: protein-coding
Summary: Enables disordered domain specific binding activity; enzyme binding activity; and unfolded protein binding activity. Involved in negative regulation of inclusion body assembly and protein refolding. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, male meiosis I, male meiotic nuclear division, negative regulation of inclusion body assembly, positive regulation of G2/M transition of mitotic cell cycle, protein folding, protein refolding, response to cold, response to heat, response to unfolded protein, spermatid development, spermatogenesis, synaptonemal complex disassembly; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, enzyme binding, glycolipid binding, heat shock protein binding, nucleotide binding, protein binding, protein folding chaperone, protein-folding chaperone binding, tau protein binding, unfolded protein binding; CC: CatSper complex, blood microparticle, cell surface, cytoplasm, cytoskeleton, cytosol, extracellular exosome, male germ cell nucleus, meiotic spindle, membrane, nucleus, plasma membrane, spindle, synaptonemal complex
Pathways: Antigen processing and presentation - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Attenuation phase, Cell Cycle, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Endocytosis - Homo sapiens (human), Estrogen signaling pathway - Homo sapiens (human), HSF1-dependent transactivation, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Immune System, Interferon Signaling, Legionellosis - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Longevity regulating pathway - multiple species - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Measles - Homo sapiens (human), Meiosis, Meiotic synapsis, PKR-mediated signaling, Parkin-Ubiquitin Proteasomal System pathway, Prion disease - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of HSF1-mediated heat shock response, Reproduction, Spliceosome - Homo sapiens (human), Toxoplasmosis - Homo sapiens (human)
UniProt: P54652
Entrez ID: 3306
|
Does Knockout of ADCK2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
ADCK2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ADCK2 (aarF domain containing kinase 2)
Type: protein-coding
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein serine/threonine kinase activity, transferase activity; CC: membrane, mitochondrion
Pathways:
UniProt: Q7Z695
Entrez ID: 90956
|
Does Inhibition of MRPL39 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
MRPL39
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MRPL39 (mitochondrial ribosomal protein L39)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: RNA binding, nucleotide binding; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways:
UniProt: Q9NYK5
Entrez ID: 54148
|
Does Knockout of GPR108 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
GPR108
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: GPR108 (G protein-coupled receptor 108)
Type: protein-coding
Summary: Predicted to be involved in negative regulation of toll-like receptor signaling pathway. Located in trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: defense response to virus, negative regulation of toll-like receptor signaling pathway, regulation of immune response, type I interferon-mediated signaling pathway; CC: Golgi apparatus, Golgi membrane, cis-Golgi network membrane, membrane, trans-Golgi network
Pathways:
UniProt: Q9NPR9
Entrez ID: 56927
|
Does Knockout of NUP155 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
NUP155
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: NUP155 (nucleoporin 155)
Type: protein-coding
Summary: Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013].
Gene Ontology: BP: RNA export from nucleus, atrial cardiac muscle cell action potential, mRNA export from nucleus, mRNA transport, miRNA processing, nuclear envelope organization, nucleocytoplasmic transport, protein import into nucleus, protein localization to nuclear inner membrane, protein localization to nucleus, protein transport, transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; MF: protein binding, structural constituent of nuclear pore; CC: cytosol, membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: O75694
Entrez ID: 9631
|
Does Activation of CD59 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
CD59
|
response to virus
|
Hepatoma Cell Line
|
Gene: CD59 (CD59 molecule (CD59 blood group))
Type: protein-coding
Summary: This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: blood coagulation, cell surface receptor signaling pathway, complement activation, negative regulation of activation of membrane attack complex, negative regulation of complement activation, negative regulation of complement-dependent cytotoxicity, regulation of complement activation, regulation of complement-dependent cytotoxicity; MF: complement binding, protein binding, protein sequestering activity; CC: ER to Golgi transport vesicle membrane, Golgi membrane, cell surface, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, focal adhesion, membrane, plasma membrane, side of membrane, specific granule membrane, tertiary granule membrane, transport vesicle, vesicle
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, Cargo concentration in the ER, Complement and coagulation cascades - Homo sapiens (human), Complement cascade, Complement system, EGFR1, ER to Golgi Anterograde Transport, Hematopoietic cell lineage - Homo sapiens (human), Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, Regulation of Complement cascade, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P13987
Entrez ID: 966
|
Does Activation of RRAD in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
RRAD
|
protein/peptide accumulation
|
T cell
|
Gene: RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator)
Type: protein-coding
Summary: Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Implicated in type 2 diabetes mellitus. Biomarker of congestive heart failure. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTP binding, GTPase activity, calcium channel regulator activity, calmodulin binding, nucleotide binding, protein binding; CC: cytosol, membrane, plasma membrane
Pathways: Insulin Signaling, NGF-stimulated transcription, Nuclear Events (kinase and transcription factor activation), Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Validated transcriptional targets of deltaNp63 isoforms
UniProt: P55042
Entrez ID: 6236
|
Does Knockout of CPXM2 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
CPXM2
|
response to virus
|
Hepatoma Cell Line
|
Gene: CPXM2 (carboxypeptidase X, M14 family member 2)
Type: protein-coding
Summary: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metallocarboxypeptidase activity, zinc ion binding
Pathways:
UniProt: Q8N436
Entrez ID: 119587
|
Does Knockout of GLRX5 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
GLRX5
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: GLRX5 (glutaredoxin 5)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010].
Gene Ontology: BP: [2Fe-2S] cluster assembly, cell redox homeostasis, hemopoiesis, intracellular iron ion homeostasis, iron-sulfur cluster assembly, protein maturation; MF: 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding, protein binding; CC: dendrite, iron-sulfur cluster assembly complex, mitochondrial matrix, mitochondrion, neuronal cell body
Pathways: Metabolism, Mitochondrial iron-sulfur cluster biogenesis
UniProt: Q86SX6
Entrez ID: 51218
|
Does Knockout of PAG1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
PAG1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: PAG1 (phosphoprotein membrane anchor with glycosphingolipid microdomains 1)
Type: protein-coding
Summary: The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adaptive immune response, immune system process, intracellular signal transduction, negative regulation of T cell activation, regulation of T cell activation, signal transduction; MF: SH2 domain binding, protein binding, signaling adaptor activity; CC: membrane, membrane raft, plasma membrane
Pathways: Adaptive Immune System, BCR signaling pathway, CXCR4-mediated signaling events, GAB1 signalosome, Immune System, PDGFR-beta signaling pathway, Phosphorylation of CD3 and TCR zeta chains, SHP2 signaling, Signal Transduction, Signaling by EGFR, Signaling by Receptor Tyrosine Kinases, TCR, TCR signaling, TCR signaling in naïve CD4+ T cells, TCR signaling in naïve CD8+ T cells
UniProt: Q9NWQ8
Entrez ID: 55824
|
Does Knockout of ZNF292 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
ZNF292
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ZNF292 (zinc finger protein 292)
Type: protein-coding
Summary: This gene encodes a growth hormone-dependent, zinc finger transcription factor that functions as a tumor suppressor. Naturally occurring mutations in this gene are associated with gastric cancer, colorectal cancer, and chronic lymphocytic leukemia. [provided by RefSeq, May 2017].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: O60281
Entrez ID: 23036
|
Does Knockout of MED23 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
MED23
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MED23 (mediator complex subunit 23)
Type: protein-coding
Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of T cell extravasation, positive regulation of gene expression, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: protein binding, transcription coactivator activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Hedgehog, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9ULK4
Entrez ID: 9439
|
Does Knockout of ARHGAP44 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
ARHGAP44
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: ARHGAP44 (Rho GTPase activating protein 44)
Type: protein-coding
Summary: Enables phospholipid binding activity. Predicted to be involved in several processes, including modification of dendritic spine; negative regulation of Rac protein signal transduction; and regulation of plasma membrane bounded cell projection organization. Located in leading edge membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: exocytosis, modification of postsynaptic structure, modulation of chemical synaptic transmission, negative regulation of Rac protein signal transduction, negative regulation of filopodium assembly, regulation of GTPase activity, regulation of actin cytoskeleton organization, regulation of dendritic spine morphogenesis, regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane, regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity, phospholipid binding, protein binding, small GTPase binding; CC: cell projection, cytoplasm, cytosol, dendrite, dendritic spine, endosome, glutamatergic synapse, leading edge membrane, plasma membrane, postsynapse, postsynaptic density, presynapse, presynaptic active zone, recycling endosome, synapse
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q17R89
Entrez ID: 9912
|
Does Knockout of RRM1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
RRM1
|
cell proliferation
|
Cancer Cell Line
|
Gene: RRM1 (ribonucleotide reductase catalytic subunit M1)
Type: protein-coding
Summary: This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: 2'-deoxyribonucleotide biosynthetic process, DNA repair, DNA synthesis involved in DNA repair, cell proliferation in forebrain, deoxyribonucleotide biosynthetic process, male gonad development, mitochondrial DNA replication, positive regulation of G0 to G1 transition, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of G2/M transition of mitotic cell cycle, protein heterotetramerization, pyrimidine nucleobase metabolic process, response to ionizing radiation, retina development in camera-type eye, ribonucleoside diphosphate metabolic process; MF: ATP binding, catalytic activity, disordered domain specific binding, identical protein binding, nucleotide binding, oxidoreductase activity, protein binding, purine nucleotide binding, ribonucleoside-diphosphate reductase activity, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; CC: cell projection, centriolar satellite, ciliary basal body, cytoplasm, cytosol, mitochondrion, neuronal cell body, nuclear envelope, ribonucleoside-diphosphate reductase complex
Pathways: AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Drug metabolism - other enzymes - Homo sapiens (human), E2F transcription factor network, Fluoropyrimidine Activity, Gemcitabine Action Pathway, Gemcitabine Metabolism Pathway, Glutathione metabolism - Homo sapiens (human), Gout or Kelley-Seegmiller Syndrome, Interconversion of nucleotide di- and triphosphates, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide metabolism, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), Retinoblastoma gene in cancer, Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, adenosine deoxyribonucleotides <i>de novo</i> biosynthesis, guanosine deoxyribonucleotides <i>de novo</i> biosynthesis, guanosine nucleotides <i>de novo</i> biosynthesis, purine nucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides biosynthesis from CTP, superpathway of purine nucleotide salvage, superpathway of pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis
UniProt: P23921
Entrez ID: 6240
|
Does Knockout of DUT in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
DUT
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: DUT (deoxyuridine triphosphatase)
Type: protein-coding
Summary: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, dTMP biosynthetic process, dUMP biosynthetic process, dUTP catabolic process, liver development, nucleobase-containing compound metabolic process, nucleotide metabolic process, pyrimidine deoxyribonucleoside monophosphate biosynthetic process, pyrimidine deoxyribonucleotide biosynthetic process, regulation of protein-containing complex assembly; MF: RNA binding, dUTP diphosphatase activity, hydrolase activity, identical protein binding, magnesium ion binding, peroxisome proliferator activated receptor binding, protein binding, pyrimidine deoxyribonucleotide binding, signaling receptor inhibitor activity; CC: extracellular exosome, mitochondrion, nucleoplasm, nucleus
Pathways: Beta Ureidopropionase Deficiency, Dihydropyrimidinase Deficiency, Drug metabolism - other enzymes - Homo sapiens (human), Interconversion of nucleotide di- and triphosphates, MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy), Metabolism, Metabolism of nucleotides, Pyrimidine Metabolism, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), UMP Synthase Deiciency (Orotic Aciduria), mechanism of gene regulation by peroxisome proliferators via ppara, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, superpathway of pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis
UniProt: P33316
Entrez ID: 1854
|
Does Knockout of NOL12 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
NOL12
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: NOL12 (nucleolar protein 12)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, identical protein binding, protein binding, rRNA binding, single-stranded DNA binding; CC: cytoplasm, nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9UGY1
Entrez ID: 79159
|
Does Knockout of NPLOC4 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
NPLOC4
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: NPLOC4 (NPL4 homolog, ubiquitin recognition factor)
Type: protein-coding
Summary: Predicted to enable ATPase binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and proteolysis involved in cellular protein catabolic process. Located in nucleus. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERAD pathway, Golgi organization, negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, proteasome-mediated ubiquitin-dependent protein catabolic process, retrograde protein transport, ER to cytosol, ubiquitin-dependent protein catabolic process; MF: ATPase binding, K48-linked polyubiquitin modification-dependent protein binding, K63-linked polyubiquitin modification-dependent protein binding, metal ion binding, protein binding, protein-containing complex binding, ubiquitin binding, ubiquitin protein ligase binding, zinc ion binding; CC: UFD1-NPL4 complex, VCP-NPL4-UFD1 AAA ATPase complex, cytoplasm, cytosol, endoplasmic reticulum, nuclear outer membrane-endoplasmic reticulum membrane network, nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, DNA Damage Bypass, DNA Repair, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Translation, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q8TAT6
Entrez ID: 55666
|
Does Knockout of RAD51B in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
RAD51B
|
response to virus
|
Lung Cancer Cell Line
|
Gene: RAD51B (RAD51 paralog B)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, blastocyst growth, double-strand break repair via homologous recombination, in utero embryonic development, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell population proliferation, reciprocal meiotic recombination, somite development; MF: ATP binding, ATP-dependent DNA damage sensor activity, ATP-dependent activity, acting on DNA, DNA binding, double-stranded DNA binding, four-way junction DNA binding, nucleotide binding, protein binding, single-stranded DNA binding; CC: Rad51B-Rad51C-Rad51D-XRCC2 complex, nucleoplasm, nucleus, replication fork
Pathways: DNA Double-Strand Break Repair, DNA Repair, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Defective homologous recombination repair (HRR) due to BRCA1 loss of function, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Defective homologous recombination repair (HRR) due to PALB2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Factors involved in megakaryocyte development and platelet production, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hemostasis, Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to PALB2, Presynaptic phase of homologous DNA pairing and strand exchange, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
UniProt: O15315
Entrez ID: 5890
|
Does Knockout of SND1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
SND1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: SND1 (staphylococcal nuclease and tudor domain containing 1)
Type: protein-coding
Summary: This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016].
Gene Ontology: BP: mRNA catabolic process, miRNA catabolic process, osteoblast differentiation, regulation of cell cycle process, regulatory ncRNA-mediated gene silencing; MF: RISC complex binding, RNA binding, RNA endonuclease activity, cadherin binding, endonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, protein binding, transcription coregulator activity; CC: RNAi effector complex, cytoplasm, cytosol, dense body, extracellular exosome, melanosome, membrane, nucleus
Pathways: C-MYB transcription factor network, Disease, Diseases of signal transduction by growth factor receptors and second messengers, IL4, Oncogenic MAPK signaling, Signaling by BRAF and RAF1 fusions, VEGFA-VEGFR2 Signaling Pathway, Viral carcinogenesis - Homo sapiens (human)
UniProt: Q7KZF4
Entrez ID: 27044
|
Does Knockout of RPS11 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
RPS11
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: RPS11 (ribosomal protein S11)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S17P family of ribosomal proteins that is a component of the 40S subunit. This gene is co-transcribed with the small nucleolar RNA gene U35B, which is located in the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: cytoplasmic translation, ribosomal small subunit biogenesis, translation; MF: RNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, IL-18 signaling pathway, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, TNFalpha, Translation, Translation initiation complex formation, VEGFA-VEGFR2 Signaling Pathway, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62280
Entrez ID: 6205
|
Does Knockout of CHMP5 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
CHMP5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: CHMP5 (charged multivesicular body protein 5)
Type: protein-coding
Summary: CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: ESCRT III complex disassembly, autophagosome maturation, autophagy, cellular response to lipopolysaccharide, cellular response to muramyl dipeptide, endosome to lysosome transport, erythrocyte differentiation, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, lysosome organization, membrane fission, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein transport, regulation of centrosome duplication, regulation of mitotic spindle assembly, regulation of receptor recycling, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding, viral budding from plasma membrane, viral budding via host ESCRT complex; MF: cadherin binding, protein binding; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, cytoplasm, cytosol, endosome, endosome membrane, extracellular exosome, kinetochore, kinetochore microtubule, lysosomal membrane, membrane, midbody, multivesicular body, multivesicular body membrane, nuclear pore, nucleus, plasma membrane
Pathways: Budding and maturation of HIV virion, Disease, Endocytosis - Homo sapiens (human), Endosomal Sorting Complex Required For Transport (ESCRT), HIV Infection, HIV Life Cycle, Infectious disease, Late Phase of HIV Life Cycle, Membrane Trafficking, Necroptosis - Homo sapiens (human), Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q9NZZ3
Entrez ID: 51510
|
Does Knockout of B2M in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
B2M
|
response to virus
|
Hepatoma Cell Line
|
Gene: B2M (beta-2-microglobulin)
Type: protein-coding
Summary: This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014].
Gene Ontology: BP: T cell differentiation in thymus, T cell mediated cytotoxicity, amyloid fibril formation, antibacterial humoral response, antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent, antigen processing and presentation of peptide antigen via MHC class I, antimicrobial humoral immune response mediated by antimicrobial peptide, cellular response to iron ion, cellular response to iron(III) ion, cellular response to lipopolysaccharide, cellular response to nicotine, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, immune response, immune system process, innate immune response, intracellular iron ion homeostasis, iron ion transport, learning or memory, multicellular organismal-level iron ion homeostasis, negative regulation of epithelial cell proliferation, negative regulation of forebrain neuron differentiation, negative regulation of iron ion transport, negative regulation of neurogenesis, negative regulation of neuron projection development, negative regulation of receptor-mediated endocytosis, peptide antigen assembly with MHC class I protein complex, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of T cell cytokine production, positive regulation of T cell mediated cytotoxicity, positive regulation of cellular senescence, positive regulation of immune response, positive regulation of receptor-mediated endocytosis, protein homotetramerization, protein refolding, regulation of erythrocyte differentiation, regulation of iron ion transport, regulation of membrane depolarization, response to metal ion, response to molecule of bacterial origin, sensory perception of smell, transferrin transport; MF: MHC class II protein complex binding, identical protein binding, peptide antigen binding, protein binding, protein homodimerization activity, structural molecule activity; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, HFE-transferrin receptor complex, MHC class I peptide loading complex, MHC class I protein complex, MHC class II protein complex, cell surface, cytosol, early endosome lumen, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum lumen, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, focal adhesion, late endosome membrane, lysosomal membrane, membrane, phagocytic vesicle membrane, plasma membrane, recycling endosome membrane, specific granule lumen, tertiary granule lumen
Pathways: Antigen processing and presentation - Homo sapiens (human), Downstream signaling in naïve CD8+ T cells, Epstein-Barr virus infection - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), IL-18 signaling pathway, IL12-mediated signaling events, TCR signaling in naïve CD8+ T cells, antigen processing and presentation, ras-independent pathway in nk cell-mediated cytotoxicity
UniProt: P61769
Entrez ID: 567
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Does Knockout of TBXT in Cervical Adenocarcinoma Cell Line causally result in response to virus?
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| 2,430
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Knockout
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TBXT
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response to virus
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Cervical Adenocarcinoma Cell Line
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Gene: TBXT (T-box transcription factor T)
Type: protein-coding
Summary: The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Variation in this gene was associated with susceptibility to neural tube defects and chordoma. A mutation in this gene was found in a family with sacral agenesis with vertebral anomalies. [provided by RefSeq, Sep 2018].
Gene Ontology: BP: anterior/posterior axis specification, embryo, cardiac muscle cell myoblast differentiation, cell fate specification, heart morphogenesis, mesoderm development, mesoderm formation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, primitive streak formation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, signal transduction, somitogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, sequence-specific double-stranded DNA binding, transcription corepressor activity; CC: chromatin, nucleoplasm, nucleus
Pathways: Cardiac Progenitor Differentiation, Cardiogenesis, Developmental Biology, Epithelial-Mesenchymal Transition (EMT) during gastrulation, Formation of axial mesoderm, Formation of definitive endoderm, Formation of paraxial mesoderm, Gastrulation, Germ layer formation at gastrulation, Regulation of nuclear beta catenin signaling and target gene transcription, Validated transcriptional targets of deltaNp63 isoforms
UniProt: O15178
Entrez ID: 6862
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