prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of USP24 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | USP24 | response to virus | Hepatoma Cell Line | Gene: USP24 (ubiquitin specific peptidase 24)
Type: protein-coding
Summary: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine... |
Does Knockout of LTV1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | LTV1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: LTV1 (LTV1 ribosome biogenesis factor)
Type: protein-coding
Summary: Predicted to be involved in ribosomal small subunit biogenesis and ribosomal small subunit export from nucleus. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ... |
Does Knockout of DTL in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | DTL | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: DTL (denticleless E3 ubiquitin protein ligase adapter)
Type: protein-coding
Summary: Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in ce... |
Does Knockout of CEBPZ in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | CEBPZ | cell proliferation | Melanoma Cell Line | Gene: CEBPZ (CCAAT enhancer binding protein zeta)
Type: protein-coding
Summary: This gene belongs to the CBF/Mak21 family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock... |
Does Knockout of CDH8 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | CDH8 | cell proliferation | T-lymphoma cell line | Gene: CDH8 (cadherin 8)
Type: protein-coding
Summary: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single mem... |
Does Knockout of USP5 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | USP5 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: USP5 (ubiquitin specific peptidase 5)
Type: protein-coding
Summary: Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal protei... |
Does Knockout of SCN4A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | SCN4A | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SCN4A (sodium voltage-gated channel alpha subunit 4)
Type: protein-coding
Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generatio... |
Does Knockout of FAM193A in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | FAM193A | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: FAM193A (family with sequence similarity 193 member A)
Type: protein-coding
Summary: family with sequence similarity 193 member A
Gene Ontology:
Pathways:
UniProt: P78312
Entrez ID: 8603 |
Does Knockout of POLR3GL in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | POLR3GL | cell proliferation | Neuroblastoma Cell Line | Gene: POLR3GL (RNA polymerase III subunit GL)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity. Involved in transcription by RNA polymerase III. Located in nucleus. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology... |
Does Knockout of FIP1L1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | FIP1L1 | cell proliferation | Bladder Carcinoma | Gene: FIP1L1 (factor interacting with PAPOLA and CPSF1)
Type: protein-coding
Summary: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), b... |
Does Knockout of BRF2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | BRF2 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: BRF2 (BRF2 general transcription factor IIIB subunit)
Type: protein-coding
Summary: This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this ... |
Does Knockout of C9orf78 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | C9orf78 | cell proliferation | Breast Cancer Cell Line | Gene: C9orf78 (chromosome 9 open reading frame 78)
Type: protein-coding
Summary: Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, chromosome segregation, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, ... |
Does Knockout of RPS3 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 1 | 1,996 | Knockout | RPS3 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: RPS3 (ribosomal protein S3)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ... |
Does Knockout of C19orf53 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | C19orf53 | cell proliferation | Glioblastoma Cell Line | Gene: C19orf53 (chromosome 19 open reading frame 53)
Type: protein-coding
Summary: chromosome 19 open reading frame 53
Gene Ontology:
Pathways:
UniProt: Q9UNZ5
Entrez ID: 28974 |
Does Knockout of THRSP in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | THRSP | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: THRSP (thyroid hormone responsive)
Type: protein-coding
Summary: The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expresse... |
Does Knockout of CDC7 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | CDC7 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CDC7 (cell division cycle 7)
Type: protein-coding
Summary: This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene produ... |
Does Knockout of SMC5 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | SMC5 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: SMC5 (structural maintenance of chromosomes 5)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Involved in several processes, including DNA recombination; cellular senescence; and positive regulation of maintenance of mitotic sister chromatid cohesion. Located in cell junct... |
Does Knockout of NDUFS2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | NDUFS2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)
Type: protein-coding
Summary: The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, ... |
Does Knockout of ZNF224 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | ZNF224 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: ZNF224 (zinc finger protein 224)
Type: protein-coding
Summary: This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also... |
Does Knockout of ZNF135 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | ZNF135 | response to chemicals | Monocytic Leukemia Cell Line | Gene: ZNF135 (zinc finger protein 135)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cytoskeleton organization and regulation of cell ... |
Does Knockout of TTC23L in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | TTC23L | cell proliferation | Glioblastoma Cell Line | Gene: TTC23L (tetratricopeptide repeat domain 23 like)
Type: protein-coding
Summary: Predicted to be located in cytoplasm; microtubule cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: centrosome, cytoplasm, cytoskeleton, midbody, spindle
... |
Does Knockout of CTPS1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | CTPS1 | cell proliferation | Gastric Cancer Cell Line | Gene: CTPS1 (CTP synthase 1)
Type: protein-coding
Summary: This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten ... |
Does Knockout of BRCA2 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | BRCA2 | cell proliferation | Breast Cancer Cell Line | Gene: BRCA2 (BRCA2 DNA repair associated)
Type: protein-coding
Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombinatio... |
Does Knockout of SMC2 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | SMC2 | cell proliferation | Colonic Cancer Cell Line | Gene: SMC2 (structural maintenance of chromosomes 2)
Type: protein-coding
Summary: Predicted to enable ATP binding activity; chromatin binding activity; and single-stranded DNA binding activity. Involved in mitotic chromosome condensation. Located in condensed chromosome; cytoplasm; and nuclear lumen. P... |
Does Knockout of NASP in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | NASP | cell proliferation | Cancer Cell Line | Gene: NASP (nuclear autoantigenic sperm protein)
Type: protein-coding
Summary: This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in ... |
Does Knockout of CDC73 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | CDC73 | cell proliferation | Cancer Cell Line | Gene: CDC73 (cell division cycle 73)
Type: protein-coding
Summary: This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and... |
Does Knockout of SACM1L in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | SACM1L | cell proliferation | Gastric Cancer Cell Line | Gene: SACM1L (SAC1 like phosphatidylinositide phosphatase)
Type: protein-coding
Summary: This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol... |
Does Knockout of FAM86B2 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | FAM86B2 | response to virus | Lung Cancer Cell Line | Gene: FAM86B2 (family with sequence similarity 86 member B2)
Type: protein-coding
Summary: Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: methylt... |
Does Knockout of SLBP in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | SLBP | cell proliferation | Glioblastoma Cell Line | Gene: SLBP (stem-loop histone mRNA binding protein)
Type: protein-coding
Summary: This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The ... |
Does Knockout of DPM3 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | DPM3 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: DPM3 (dolichyl-phosphate mannosyltransferase subunit 3, regulatory)
Type: protein-coding
Summary: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-an... |
Does Knockout of CAPZB in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | CAPZB | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: CAPZB (capping actin protein of muscle Z-line subunit beta)
Type: protein-coding
Summary: This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin ... |
Does Knockout of LDAH in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | LDAH | cell proliferation | Gastric Cancer Cell Line | Gene: LDAH (lipid droplet associated hydrolase)
Type: protein-coding
Summary: Predicted to enable lipase activity. Predicted to be involved in lipid storage. Predicted to be located in endoplasmic reticulum. Predicted to be active in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of NUTM2G in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | NUTM2G | cell proliferation | Mammary Gland Tumor Cell Line | Gene: NUTM2G (NUT family member 2G)
Type: protein-coding
Summary: NUT family member 2G
Gene Ontology:
Pathways:
UniProt: Q5VZR2
Entrez ID: 441457 |
Does Knockout of CSTF1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | CSTF1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: CSTF1 (cleavage stimulation factor subunit 1)
Type: protein-coding
Summary: This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this ... |
Does Knockout of RAB6A in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | RAB6A | cell proliferation | Colonic Cancer Cell Line | Gene: RAB6A (RAB6A, member RAS oncogene family)
Type: protein-coding
Summary: This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartmen... |
Does Knockout of KCNIP4 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | KCNIP4 | cell proliferation | Colonic Cancer Cell Line | Gene: KCNIP4 (potassium voltage-gated channel interacting protein 4)
Type: protein-coding
Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family ... |
Does Knockout of TBC1D17 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | TBC1D17 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: TBC1D17 (TBC1 domain family member 17)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Involved in retrograde transport, endosome to Golgi. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagy, protein transport... |
Does Knockout of LGALS8 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | LGALS8 | cell proliferation | Colorectal Cancer Cell Line | Gene: LGALS8 (galectin 8)
Type: protein-coding
Summary: This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differen... |
Does Knockout of ITM2C in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | ITM2C | cell proliferation | Endometrial Cancer Cell Line | Gene: ITM2C (integral membrane protein 2C)
Type: protein-coding
Summary: Enables amyloid-beta binding activity. Involved in negative regulation of neuron projection development and neuron differentiation. Located in several cellular components, including Golgi apparatus; lysosome; and perinuclear region... |
Does Knockout of PITX2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | PITX2 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: PITX2 (paired like homeodomain 2)
Type: protein-coding
Summary: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This pr... |
Does Knockout of ZNF407 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | ZNF407 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ZNF407 (zinc finger protein 407)
Type: protein-coding
Summary: This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptional regulation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [... |
Does Knockout of MED11 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | MED11 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: MED11 (mediator complex subunit 11)
Type: protein-coding
Summary: MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008].
Gene Ontolog... |
Does Knockout of GOLGA6D in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | GOLGA6D | response to virus | Hepatoma Cell Line | Gene: GOLGA6D (golgin A6 family member D)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Apr... |
Does Knockout of ANXA11 in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | ANXA11 | cell proliferation | Bladder Carcinoma | Gene: ANXA11 (annexin A11)
Type: protein-coding
Summary: This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The... |
Does Knockout of ANGPTL5 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | ANGPTL5 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: ANGPTL5 (angiopoietin like 5)
Type: protein-coding
Summary: Predicted to be active in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular matrix, extracellular region, extracellular space
... |
Does Knockout of TLCD2 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | TLCD2 | cell proliferation | Medulloblastoma Cell Line | Gene: TLCD2 (TLC domain containing 2)
Type: protein-coding
Summary: Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology... |
Does Knockout of MED10 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | MED10 | cell proliferation | Colonic Cancer Cell Line | Gene: MED10 (mediator complex subunit 10)
Type: protein-coding
Summary: MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008].
Gene Ontolog... |
Does Knockout of PGD in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | PGD | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: PGD (phosphogluconate dehydrogenase)
Type: protein-coding
Summary: 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from co... |
Does Activation of FAM163A in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | FAM163A | protein/peptide accumulation | T cell | Gene: FAM163A (family with sequence similarity 163 member A)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q96GL9
Entrez ID: 148753 |
Does Knockout of AGBL1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | AGBL1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: AGBL1 (AGBL carboxypeptidase 1)
Type: protein-coding
Summary: Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the... |
Does Knockout of MST1 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | MST1 | response to chemicals | Melanoma Cell Line | Gene: MST1 (macrophage stimulating 1)
Type: protein-coding
Summary: The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteo... |
Does Knockout of WDR5 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | WDR5 | cell proliferation | T-lymphoma cell line | Gene: WDR5 (WD repeat domain 5)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or mul... |
Does Knockout of PPIL6 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | PPIL6 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: PPIL6 (peptidylprolyl isomerase like 6)
Type: protein-coding
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resour... |
Does Knockout of MRPL54 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | MRPL54 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: MRPL54 (mitochondrial ribosomal protein L54)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of PRY2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | PRY2 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: PRY2 (PTPN13 like Y-linked 2)
Type: ncRNA
Summary: This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more centromeric copy. [provided b... |
Does Knockout of LARGE2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | LARGE2 | cell proliferation | Colonic Cancer Cell Line | Gene: LARGE2 (LARGE xylosyl- and glucuronyltransferase 2)
Type: protein-coding
Summary: Predicted to enable dystroglycan binding activity; glucuronosyltransferase activity; and xylosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in intracellular membrane-boun... |
Does Knockout of ACTR1B in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | ACTR1B | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: ACTR1B (actin related protein 1B)
Type: protein-coding
Summary: This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of ce... |
Does Knockout of MAPK1 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | MAPK1 | cell proliferation | Neuroblastoma Cell Line | Gene: MAPK1 (mitogen-activated protein kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety o... |
Does Knockout of PDCL3 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | PDCL3 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: PDCL3 (phosducin like 3)
Type: protein-coding
Summary: This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family ha... |
Does Knockout of FGF8 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | FGF8 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: FGF8 (fibroblast growth factor 8)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embry... |
Does Knockout of FBXO16 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | FBXO16 | response to chemicals | Glioblastoma Cell Line | Gene: FBXO16 (F-box protein 16)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called S... |
Does Knockout of MPHOSPH10 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | MPHOSPH10 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: MPHOSPH10 (M-phase phosphoprotein 10)
Type: protein-coding
Summary: This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotei... |
Does Knockout of CTDSPL2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | CTDSPL2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CTDSPL2 (CTD small phosphatase like 2)
Type: protein-coding
Summary: Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to act upstream of or within negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; and protein dephosph... |
Does Knockout of DNAL4 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | DNAL4 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: DNAL4 (dynein axonemal light chain 4)
Type: protein-coding
Summary: This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encod... |
Does Knockout of KRT85 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | KRT85 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: KRT85 (keratin 85)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chrom... |
Does Knockout of UBAC1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | UBAC1 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: UBAC1 (UBA domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in protein ubiquitination. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein maturation, protein ubiquitination; M... |
Does Knockout of STK11 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | STK11 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: STK11 (serine/threonine kinase 11)
Type: protein-coding
Summary: The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghe... |
Does Knockout of PFDN6 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | PFDN6 | cell proliferation | Breast Cancer Cell Line | Gene: PFDN6 (prefoldin subunit 6)
Type: protein-coding
Summary: PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin conta... |
Does Knockout of CNOT7 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | CNOT7 | cell proliferation | Gastric Cancer Cell Line | Gene: CNOT7 (CCR4-NOT transcription complex subunit 7)
Type: protein-coding
Summary: The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of ... |
Does Knockout of ZNF207 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | ZNF207 | cell proliferation | Bladder Carcinoma | Gene: ZNF207 (zinc finger protein 207)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in several processes, including mitotic nuclear division; mitotic spindle assembly checkpoint signaling; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matri... |
Does Knockout of ATF4 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | ATF4 | cell proliferation | Colorectal Cancer Cell Line | Gene: ATF4 (activating transcription factor 4)
Type: protein-coding
Summary: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also is... |
Does Knockout of EHD3 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | EHD3 | cell proliferation | Cancer Cell Line | Gene: EHD3 (EH domain containing 3)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity. Involved in several processes, including Golgi to lysosome transport; endosomal transport; and protein homooligomerization. Acts upstream of or within protein localization to plasma membr... |
Does Knockout of DSG3 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | DSG3 | cell proliferation | Cancer Cell Line | Gene: DSG3 (desmoglein 3)
Type: protein-coding
Summary: This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial... |
Does Knockout of TAF1B in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | TAF1B | cell proliferation | Breast Cancer Cell Line | Gene: TAF1B (TATA-box binding protein associated factor, RNA polymerase I subunit B)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polym... |
Does Knockout of NCBP3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | NCBP3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: NCBP3 (nuclear cap binding subunit 3)
Type: protein-coding
Summary: Enables RNA 7-methylguanosine cap binding activity and mRNA binding activity. Involved in defense response to virus. Located in cytoplasm and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontolo... |
Does Knockout of CDCA3 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | CDCA3 | cell proliferation | Astrocytoma Cell Line | Gene: CDCA3 (cell division cycle associated 3)
Type: protein-coding
Summary: Predicted to be involved in cell division and protein ubiquitination. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, protein ubiquitination; CC: adh... |
Does Knockout of C20orf144 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 1 | 1,480 | Knockout | C20orf144 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: C20orf144 (chromosome 20 open reading frame 144)
Type: protein-coding
Summary: chromosome 20 open reading frame 144
Gene Ontology:
Pathways:
UniProt: Q9BQM9
Entrez ID: 128864 |
Does Knockout of SMG1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | SMG1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase)
Type: protein-coding
Summary: This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphoryl... |
Does Knockout of CCR5 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | CCR5 | cell proliferation | Astrocytoma Cell Line | Gene: CCR5 (C-C motif chemokine receptor 5)
Type: protein-coding
Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to... |
Does Knockout of GLCCI1 in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | GLCCI1 | cell proliferation | Prostate Cancer Cell Line | Gene: GLCCI1 (glucocorticoid induced 1)
Type: protein-coding
Summary: This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a... |
Does Knockout of TSFM in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | TSFM | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: TSFM (Ts translation elongation factor, mitochondrial)
Type: protein-coding
Summary: This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation st... |
Does Knockout of GPX4 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | GPX4 | cell proliferation | Medulloblastoma Cell Line | Gene: GPX4 (glutathione peroxidase 4)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative da... |
Does Knockout of SAE1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | SAE1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SAE1 (SUMO1 activating enzyme subunit 1)
Type: protein-coding
Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterod... |
Does Knockout of PTMS in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | PTMS | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: PTMS (parathymosin)
Type: protein-coding
Summary: Predicted to be involved in DNA replication. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA replication, immune system process, negative regulation of apoptotic process, posi... |
Does Knockout of SLC2A1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | SLC2A1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: SLC2A1 (solute carrier family 2 member 1)
Type: protein-coding
Summary: This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell... |
Does Knockout of RNPS1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | RNPS1 | cell proliferation | Gastric Cancer Cell Line | Gene: RNPS1 (RNA binding protein with serine rich domain 1)
Type: protein-coding
Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading fram... |
Does Knockout of ARFRP1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | ARFRP1 | cell proliferation | Glioblastoma Cell Line | Gene: ARFRP1 (ARF related protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking betw... |
Does Knockout of RPL5 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | RPL5 | cell proliferation | Medulloblastoma Cell Line | Gene: RPL5 (ribosomal protein L5)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encod... |
Does Knockout of RACGAP1 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | RACGAP1 | cell proliferation | Neuroblastoma Cell Line | Gene: RACGAP1 (Rac GTPase activating protein 1)
Type: protein-coding
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of R... |
Does Knockout of RAB10 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | RAB10 | cell proliferation | Cancer Cell Line | Gene: RAB10 (RAB10, member RAS oncogene family)
Type: protein-coding
Summary: RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[sup... |
Does Knockout of POLA2 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | POLA2 | cell proliferation | Cancer Cell Line | Gene: POLA2 (DNA polymerase alpha 2, accessory subunit)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Involved in DNA replication, synthesis of RNA primer. Located in cytosol and nucleoplasm. Part of alpha DNA polymerase:primase complex. [provided by Alliance of Genome Resource... |
Does Knockout of RNF175 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | RNF175 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: RNF175 (ring finger protein 175)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum mem... |
Does Knockout of DAD1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | DAD1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: DAD1 (defender against cell death 1)
Type: protein-coding
Summary: DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells f... |
Does Knockout of LETM1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | LETM1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: LETM1 (leucine zipper and EF-hand containing transmembrane protein 1)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphol... |
Does Knockout of TOM1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | TOM1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: TOM1 (target of myb1 membrane trafficking protein)
Type: protein-coding
Summary: This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endoso... |
Does Activation of TAS2R50 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | TAS2R50 | protein/peptide accumulation | T cell | Gene: TAS2R50 (taste 2 receptor member 50)
Type: protein-coding
Summary: TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubM... |
Does Knockout of SNRPE in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | SNRPE | cell proliferation | Monocytic Leukemia Cell Line | Gene: SNRPE (small nuclear ribonucleoprotein polypeptide E)
Type: protein-coding
Summary: The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing... |
Does Knockout of FIG4 in Huh-7 Cell causally result in response to virus? | 1 | 1,382 | Knockout | FIG4 | response to virus | Huh-7 Cell | Gene: FIG4 (FIG4 phosphoinositide 5-phosphatase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoino... |
Does Knockout of KIN in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | KIN | cell proliferation | Astrocytoma Cell Line | Gene: KIN (Kin17 DNA and RNA binding protein)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of t... |
Does Knockout of GCSAML in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | GCSAML | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: GCSAML (germinal center associated signaling and motility like)
Type: protein-coding
Summary: This gene encodes a protein thought to be a signaling molecule associated with germinal centers, the sites of proliferation and differentiation of mature B lymphocytes. Alternate splicing results in multi... |
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