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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of USP24 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
USP24
|
response to virus
|
Hepatoma Cell Line
|
Gene: USP24 (ubiquitin specific peptidase 24)
Type: protein-coding
Summary: Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: protein deubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q9UPU5
Entrez ID: 23358
|
Does Knockout of LTV1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
LTV1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: LTV1 (LTV1 ribosome biogenesis factor)
Type: protein-coding
Summary: Predicted to be involved in ribosomal small subunit biogenesis and ribosomal small subunit export from nucleus. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus, ribosome biogenesis; CC: cytoplasm, cytosol, nucleoplasm, nucleus, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q96GA3
Entrez ID: 84946
|
Does Knockout of DTL in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
DTL
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: DTL (denticleless E3 ubiquitin protein ligase adapter)
Type: protein-coding
Summary: Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in centrosome; cytosol; and nuclear lumen. Part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA replication, mitotic G2 DNA damage checkpoint signaling, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of catabolic process, positive regulation of protein catabolic process, positive regulation of protein metabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of cell cycle, response to UV, rhythmic process, translesion synthesis, ubiquitin-dependent protein catabolic process; MF: protein binding, protein-macromolecule adaptor activity, ubiquitin-protein transferase activity; CC: Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, centrosome, chromosome, cytoplasm, cytoskeleton, cytosol, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Repair, Metabolism of proteins, Neddylation, Post-translational protein modification, Recognition of DNA damage by PCNA-containing replication complex
UniProt: Q9NZJ0
Entrez ID: 51514
|
Does Knockout of CEBPZ in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
CEBPZ
|
cell proliferation
|
Melanoma Cell Line
|
Gene: CEBPZ (CCAAT enhancer binding protein zeta)
Type: protein-coding
Summary: This gene belongs to the CBF/Mak21 family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. [provided by RefSeq, Nov 2020].
Gene Ontology: MF: DNA binding, RNA binding, protein binding, transcription coactivator activity; CC: CCAAT-binding factor complex, nucleoplasm, nucleus
Pathways: Direct p53 effectors, Gastric Cancer Network 2
UniProt: Q03701
Entrez ID: 10153
|
Does Knockout of CDH8 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
CDH8
|
cell proliferation
|
T-lymphoma cell line
|
Gene: CDH8 (cadherin 8)
Type: protein-coding
Summary: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adherens junction organization, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, chemical synaptic transmission, homophilic cell adhesion via plasma membrane adhesion molecules, regulation of synapse organization, response to cold, synaptic transmission, glutamatergic; MF: beta-catenin binding, cadherin binding, calcium ion binding, identical protein binding, metal ion binding; CC: adherens junction, axon terminus, catenin complex, glutamatergic synapse, membrane, plasma membrane, synaptic cleft, synaptic membrane
Pathways: Adherens junctions interactions, CDH11 homotypic and heterotypic interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Ectoderm Differentiation, Hippo-Merlin Signaling Dysregulation, Pathways Regulating Hippo Signaling, Regulation of CDH11 Expression and Function, Regulation of CDH11 function, Regulation of Expression and Function of Type II Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: P55286
Entrez ID: 1006
|
Does Knockout of USP5 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
USP5
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: USP5 (ubiquitin specific peptidase 5)
Type: protein-coding
Summary: Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010].
Gene Ontology: BP: negative regulation of T cell activation, negative regulation of T cell mediated immune response to tumor cell, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of proteasomal protein catabolic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of translation, protein K48-linked deubiquitination, protein deubiquitination, protein ubiquitination, proteolysis, regulation of mitotic cell cycle, regulation of protein stability, regulation protein catabolic process at presynapse; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, metal ion binding, peptidase activity, protein binding, ubiquitin binding, zinc ion binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, lysosome, nucleus, presynapse
Pathways: IL-18 signaling pathway
UniProt: P45974
Entrez ID: 8078
|
Does Knockout of SCN4A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
SCN4A
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SCN4A (sodium voltage-gated channel alpha subunit 4)
Type: protein-coding
Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is expressed in skeletal muscle, and mutations in this gene have been linked to several myotonia and periodic paralysis disorders. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: action potential, cardiac muscle cell action potential involved in contraction, monoatomic ion transmembrane transport, monoatomic ion transport, muscle contraction, regulation of skeletal muscle contraction by action potential, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: monoatomic cation channel activity, monoatomic ion channel activity, protein binding, sodium channel activity, voltage-gated sodium channel activity; CC: membrane, monoatomic ion channel complex, plasma membrane, voltage-gated sodium channel complex
Pathways: Axon guidance, Cardiac conduction, Developmental Biology, Interaction between L1 and Ankyrins, L1CAM interactions, Muscle contraction, Nervous system development, Phase 0 - rapid depolarisation
UniProt: P35499
Entrez ID: 6329
|
Does Knockout of FAM193A in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
FAM193A
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: FAM193A (family with sequence similarity 193 member A)
Type: protein-coding
Summary: family with sequence similarity 193 member A
Gene Ontology:
Pathways:
UniProt: P78312
Entrez ID: 8603
|
Does Knockout of POLR3GL in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
POLR3GL
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: POLR3GL (RNA polymerase III subunit GL)
Type: protein-coding
Summary: Predicted to enable chromatin binding activity. Involved in transcription by RNA polymerase III. Located in nucleus. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: transcription by RNA polymerase III; CC: RNA polymerase III complex, cytosol, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , Gene expression (Transcription), Immune System, Innate Immune System, Pyrimidine metabolism, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human)
UniProt: Q9BT43
Entrez ID: 84265
|
Does Knockout of FIP1L1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
FIP1L1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: FIP1L1 (factor interacting with PAPOLA and CPSF1)
Type: protein-coding
Summary: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
Gene Ontology: MF: RNA binding, protein binding; CC: cytosol, mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Disease, Diseases of signal transduction by growth factor receptors and second messengers, Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Signaling by PDGFR in disease, Signaling by cytosolic PDGFRA and PDGFRB fusion proteins, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q6UN15
Entrez ID: 81608
|
Does Knockout of BRF2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
BRF2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: BRF2 (BRF2 general transcription factor IIIB subunit)
Type: protein-coding
Summary: This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the TATA-binding protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription initiation, cellular response to oxidative stress, regulation of transcription by RNA polymerase III, transcription by RNA polymerase II, transcription preinitiation complex assembly; MF: RNA polymerase II general transcription initiation factor activity, RNA polymerase III type 3 promoter sequence-specific DNA binding, TBP-class protein binding, metal ion binding, protein binding, zinc ion binding; CC: nucleoplasm, nucleus, transcription factor TFIIIB complex, transcription preinitiation complex
Pathways: Gene expression (Transcription), RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter
UniProt: Q9HAW0
Entrez ID: 55290
|
Does Knockout of C9orf78 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
C9orf78
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: C9orf78 (chromosome 9 open reading frame 78)
Type: protein-coding
Summary: Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, chromosome segregation, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, regulation of homologous chromosome segregation; MF: RNA binding, U5 snRNA binding, protein binding; CC: chromosome, chromosome, centromeric region, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, TCR, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9NZ63
Entrez ID: 51759
|
Does Knockout of RPS3 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
RPS3
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: RPS3 (ribosomal protein S3)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: DNA damage response, DNA repair, apoptotic process, base-excision repair, cell division, cellular response to hydrogen peroxide, cellular response to reactive oxygen species, cellular response to tumor necrosis factor, chromosome segregation, cytoplasmic translation, negative regulation of DNA repair, negative regulation of protein ubiquitination, negative regulation of translation, positive regulation of DNA repair, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell receptor signaling pathway, positive regulation of activated T cell proliferation, positive regulation of apoptotic signaling pathway, positive regulation of base-excision repair, positive regulation of endodeoxyribonuclease activity, positive regulation of gene expression, positive regulation of interleukin-2 production, positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage, positive regulation of microtubule polymerization, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of protein-containing complex assembly, regulation of apoptotic process, regulation of translation, response to TNF agonist, spindle assembly, translation, translational initiation; MF: DNA N-glycosylase activity, DNA binding, DNA endonuclease activity, DNA-(apurinic or apyrimidinic site) endonuclease activity, DNA-binding transcription factor binding, Hsp70 protein binding, Hsp90 protein binding, RNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, class I DNA-(apurinic or apyrimidinic site) endonuclease activity, damaged DNA binding, enzyme binding, iron-sulfur cluster binding, kinase binding, lyase activity, mRNA binding, microtubule binding, oxidized purine DNA binding, oxidized pyrimidine DNA binding, protein binding, protein kinase A binding, protein kinase binding, protein-containing complex binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, supercoiled DNA binding, tubulin binding, ubiquitin-like protein conjugating enzyme binding; CC: NF-kappaB complex, cytoplasm, cytoskeleton, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, extracellular exosome, focal adhesion, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, mitotic spindle, nucleolus, nucleoplasm, nucleus, plasma membrane, postsynaptic density, ribonucleoprotein complex, ribosome, ruffle membrane, small ribosomal subunit, spindle, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Pathogenic Escherichia coli infection - Homo sapiens (human), Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Salmonella infection - Homo sapiens (human), Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P23396
Entrez ID: 6188
|
Does Knockout of C19orf53 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
C19orf53
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: C19orf53 (chromosome 19 open reading frame 53)
Type: protein-coding
Summary: chromosome 19 open reading frame 53
Gene Ontology:
Pathways:
UniProt: Q9UNZ5
Entrez ID: 28974
|
Does Knockout of THRSP in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
THRSP
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: THRSP (thyroid hormone responsive)
Type: protein-coding
Summary: The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: lipid metabolic process, regulation of lipid biosynthetic process, regulation of triglyceride biosynthetic process, response to bacterium; MF: identical protein binding, molecular function inhibitor activity, protein binding, protein homodimerization activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Carnitine shuttle, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Fatty acid metabolism, Gene expression (Transcription), MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids
UniProt: Q92748
Entrez ID: 7069
|
Does Knockout of CDC7 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
CDC7
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CDC7 (cell division cycle 7)
Type: protein-coding
Summary: This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell cycle phase transition, cell division, double-strand break repair via break-induced replication, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of nuclear cell cycle DNA replication, signal transduction; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, intercellular bridge, mitotic spindle, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Gene expression (Transcription), Generic Transcription Pathway, Mitotic G1 phase and G1/S transition, RNA Polymerase II Transcription, Retinoblastoma gene in cancer, Transcriptional Regulation by E2F6
UniProt: O00311
Entrez ID: 8317
|
Does Knockout of SMC5 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
SMC5
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: SMC5 (structural maintenance of chromosomes 5)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Involved in several processes, including DNA recombination; cellular senescence; and positive regulation of maintenance of mitotic sister chromatid cohesion. Located in cell junction; chromosome; and nuclear body. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell division, cellular senescence, chromatin looping, chromosome condensation, chromosome organization, chromosome segregation, double-strand break repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, host-mediated suppression of viral genome replication, mitotic cell cycle phase transition, positive regulation of chromosome segregation, positive regulation of maintenance of mitotic sister chromatid cohesion, protein localization to chromosome, centromeric region, protein sumoylation, regulation of telomere maintenance, stem cell population maintenance, telomere maintenance via recombination; MF: ATP binding, ATP hydrolysis activity, DNA secondary structure binding, nucleotide binding, protein binding, single-stranded DNA binding; CC: PML body, Smc5-Smc6 complex, cell junction, chromosome, chromosome, centromeric region, chromosome, telomeric region, cytoplasm, interchromatin granule, nuclear speck, nucleoplasm, nucleus, sex chromosome, site of double-strand break
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q8IY18
Entrez ID: 23137
|
Does Knockout of NDUFS2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
NDUFS2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2)
Type: protein-coding
Summary: The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: aerobic respiration, cellular response to oxygen levels, gliogenesis, mitochondrial ATP synthesis coupled electron transport, mitochondrial electron transport, NADH to ubiquinone, mitochondrial respiratory chain complex I assembly, neural precursor cell proliferation, neurogenesis, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: 4 iron, 4 sulfur cluster binding, NAD binding, NADH dehydrogenase (ubiquinone) activity, NADH dehydrogenase activity, electron transfer activity, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, oxygen sensor activity, protein binding, quinone binding, ubiquitin protein ligase binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Doxorubicin Metabolism Pathway, Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human), p73 transcription factor network
UniProt: O75306
Entrez ID: 4720
|
Does Knockout of ZNF224 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
ZNF224
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: ZNF224 (zinc finger protein 224)
Type: protein-coding
Summary: This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein represses transcription of the aldolase A gene, which encodes a key enzyme in glycolysis. The encoded zinc-finger protein may also function as a transcriptional co-activator with Wilms' tumor protein 1 to regulate apoptotic genes in leukemia. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: nuclear membrane, nucleoplasm, nucleus, transcription repressor complex
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: Q9NZL3
Entrez ID: 7767
|
Does Knockout of ZNF135 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
ZNF135
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: ZNF135 (zinc finger protein 135)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cytoskeleton organization and regulation of cell morphogenesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoskeleton organization, regulation of DNA-templated transcription, regulation of anatomical structure morphogenesis, regulation of cell morphogenesis, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: P52742
Entrez ID: 7694
|
Does Knockout of TTC23L in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
TTC23L
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: TTC23L (tetratricopeptide repeat domain 23 like)
Type: protein-coding
Summary: Predicted to be located in cytoplasm; microtubule cytoskeleton; and midbody. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: centrosome, cytoplasm, cytoskeleton, midbody, spindle
Pathways:
UniProt: Q6PF05
Entrez ID: 153657
|
Does Knockout of CTPS1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
CTPS1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CTPS1 (CTP synthase 1)
Type: protein-coding
Summary: This gene encodes an enzyme responsible for the catalytic conversion of UTP (uridine triphosphate) to CTP (cytidine triphospate). This reaction is an important step in the biosynthesis of phospholipids and nucleic acids. Activity of this proten is important in the immune system, and loss of function of this gene has been associated with immunodeficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: 'de novo' CTP biosynthetic process, B cell proliferation, CTP biosynthetic process, T cell proliferation, immune system process, nucleobase-containing compound metabolic process, pyrimidine nucleobase biosynthetic process, pyrimidine nucleotide biosynthetic process, response to xenobiotic stimulus, small molecule metabolic process; MF: ATP binding, CTP synthase activity, identical protein binding, ligase activity, nucleotide binding, protein binding; CC: cytoophidium, cytoplasm, cytosol, membrane, nucleus
Pathways: Beta Ureidopropionase Deficiency, Dihydropyrimidinase Deficiency, Gemcitabine Action Pathway, Gemcitabine Metabolism Pathway, Interconversion of nucleotide di- and triphosphates, MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy), Metabolism, Metabolism of nucleotides, Pyrimidine Metabolism, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), UMP Synthase Deiciency (Orotic Aciduria), UTP and CTP <i>de novo</i> biosynthesis, UTP and CTP dephosphorylation I, UTP and CTP dephosphorylation II, superpathway of pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, superpathway of pyrimidine ribonucleotides <i>de novo</i> biosynthesis
UniProt: P17812
Entrez ID: 1503
|
Does Knockout of BRCA2 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
BRCA2
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: BRCA2 (BRCA2 DNA repair associated)
Type: protein-coding
Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020].
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA recombination, DNA repair, brain development, cell population proliferation, cellular response to ionizing radiation, cellular senescence, centrosome duplication, chordate embryonic development, chromatin remodeling, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, establishment of protein localization to telomere, female gonad development, hematopoietic stem cell proliferation, hemopoiesis, inner cell mass cell proliferation, intrinsic apoptotic signaling pathway in response to DNA damage, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, male meiosis I, mitotic recombination-dependent replication fork processing, negative regulation of mammary gland epithelial cell proliferation, nucleotide-excision repair, oocyte maturation, positive regulation of DNA-templated transcription, positive regulation of mitotic cell cycle, regulation of DNA damage checkpoint, regulation of DNA-templated transcription, regulation of cytokinesis, replication fork processing, response to UV-C, response to X-ray, response to gamma radiation, spermatogenesis, stem cell proliferation, telomere maintenance via recombination; MF: DNA binding, gamma-tubulin binding, histone H3 acetyltransferase activity, histone H4 acetyltransferase activity, histone acetyltransferase activity, identical protein binding, protease binding, protein binding, single-stranded DNA binding; CC: BRCA2-MAGE-D1 complex, DNA repair complex, centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytoskeleton, cytosol, lateral element, nuclear ubiquitin ligase complex, nucleoplasm, nucleus, protein-containing complex, secretory granule
Pathways: ATR signaling pathway, Breast cancer - Homo sapiens (human), Breast cancer pathway, Cell Cycle, DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Defective homologous recombination repair (HRR) due to BRCA1 loss of function, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Defective homologous recombination repair (HRR) due to PALB2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, FOXM1 transcription factor network, Fanconi anemia pathway, Fanconi anemia pathway - Homo sapiens (human), Glioblastoma signaling pathways, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through MMEJ (alt-NHEJ), Homologous DNA Pairing and Strand Exchange, Homologous recombination, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to PALB2, Impaired BRCA2 binding to RAD51, Impaired BRCA2 binding to SEM1 (DSS1), Impaired BRCA2 translocation to the nucleus, Integrated breast cancer pathway, Male infertility, Meiosis, Meiotic recombination, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Presynaptic phase of homologous DNA pairing and strand exchange, Reproduction, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), Validated transcriptional targets of deltaNp63 isoforms, p73 transcription factor network, role of brca1 brca2 and atr in cancer susceptibility
UniProt: P51587
Entrez ID: 675
|
Does Knockout of SMC2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
SMC2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SMC2 (structural maintenance of chromosomes 2)
Type: protein-coding
Summary: Predicted to enable ATP binding activity; chromatin binding activity; and single-stranded DNA binding activity. Involved in mitotic chromosome condensation. Located in condensed chromosome; cytoplasm; and nuclear lumen. Part of condensin complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, chromosome condensation, chromosome organization, kinetochore organization, meiotic chromosome condensation, meiotic chromosome segregation, mitotic chromosome condensation, nuclear chromosome segregation, nuclear division, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation; MF: ATP binding, ATP hydrolysis activity, chromatin binding, nucleotide binding, protein binding, single-stranded DNA binding; CC: chromatin, chromosome, condensed chromosome, condensed nuclear chromosome, condensin complex, cytoplasm, cytosol, extracellular exosome, nuclear chromosome, nucleolus, nucleoplasm, nucleus
Pathways: Aurora B signaling, Cell Cycle, Cell Cycle, Mitotic, Condensation of Prometaphase Chromosomes, Condensation of Prophase Chromosomes, M Phase, Mitotic Prometaphase, Mitotic Prophase, Retinoblastoma gene in cancer
UniProt: O95347
Entrez ID: 10592
|
Does Knockout of NASP in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
NASP
|
cell proliferation
|
Cancer Cell Line
|
Gene: NASP (nuclear autoantigenic sperm protein)
Type: protein-coding
Summary: This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: CENP-A containing chromatin assembly, DNA replication, DNA replication-dependent chromatin assembly, blastocyst development, male gonad development, nucleosome assembly, protein transport, response to testosterone; MF: histone binding, protein binding, protein-containing complex binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: P49321
Entrez ID: 4678
|
Does Knockout of CDC73 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
CDC73
|
cell proliferation
|
Cancer Cell Line
|
Gene: CDC73 (cell division cycle 73)
Type: protein-coding
Summary: This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: Wnt signaling pathway, cellular response to lipopolysaccharide, endodermal cell fate commitment, mRNA 3'-end processing, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation, negative regulation of fibroblast proliferation, negative regulation of myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of Wnt signaling pathway, positive regulation of cell cycle G1/S phase transition, positive regulation of mRNA 3'-end processing, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, protein destabilization, regulation of cell growth, regulation of transcription by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, protein binding; CC: Cdc73/Paf1 complex, chromosome, telomeric region, cytosol, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Endoderm differentiation, Formation of RNA Pol II elongation complex , Formation of the beta-catenin:TCF transactivating complex, Gene expression (Transcription), Hedgehog 'on' state, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Signal Transduction, Signaling by Hedgehog, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q6P1J9
Entrez ID: 79577
|
Does Knockout of SACM1L in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
SACM1L
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SACM1L (SAC1 like phosphatidylinositide phosphatase)
Type: protein-coding
Summary: This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame, downstream translation termination codon via a stop codon readthrough mechanism.[provided by RefSeq, Dec 2017].
Gene Ontology: BP: exocytic insertion of neurotransmitter receptor to postsynaptic membrane, lipid metabolic process, phosphatidylinositol biosynthetic process, phosphatidylinositol dephosphorylation, vesicle-mediated transport in synapse; MF: hydrolase activity, phosphatase activity, phosphatidylinositol phosphate 4-phosphatase activity, phosphatidylinositol-3-phosphate phosphatase activity, phosphatidylinositol-4-phosphate phosphatase activity, protein binding; CC: AMPA glutamate receptor complex, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, glutamatergic synapse, membrane
Pathways: 3-phosphoinositide biosynthesis, 3-phosphoinositide degradation, Inositol phosphate metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, PI Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipid metabolism, Synthesis of PIPs at the ER membrane, Synthesis of PIPs at the Golgi membrane, superpathway of inositol phosphate compounds
UniProt: Q9NTJ5
Entrez ID: 22908
|
Does Knockout of FAM86B2 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
FAM86B2
|
response to virus
|
Lung Cancer Cell Line
|
Gene: FAM86B2 (family with sequence similarity 86 member B2)
Type: protein-coding
Summary: Predicted to enable methyltransferase activity. Predicted to be involved in methylation. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: methyltransferase activity, protein binding, protein-lysine N-methyltransferase activity, transferase activity; CC: protein-containing complex
Pathways:
UniProt: P0C5J1
Entrez ID: 653333
|
Does Knockout of SLBP in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
SLBP
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SLBP (stem-loop histone mRNA binding protein)
Type: protein-coding
Summary: This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cap-dependent translational initiation, mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, mRNA transport; MF: RNA binding, histone pre-mRNA DCP binding, histone pre-mRNA stem-loop binding, identical protein binding, mRNA binding, protein binding; CC: cytoplasm, cytosol, histone mRNA stem-loop binding complex, histone pre-mRNA 3'end processing complex, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA
UniProt: Q14493
Entrez ID: 7884
|
Does Knockout of DPM3 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
DPM3
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: DPM3 (dolichyl-phosphate mannosyltransferase subunit 3, regulatory)
Type: protein-coding
Summary: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: dolichol phosphate mannose biosynthetic process, protein O-linked glycosylation via mannose, protein glycosylation; MF: endoplasmic reticulum-plasma membrane adaptor activity, enzyme activator activity, protein binding; CC: dolichol-phosphate-mannose synthase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: N-Glycan biosynthesis - Homo sapiens (human), dolichyl-diphosphooligosaccharide biosynthesis
UniProt: Q9P2X0
Entrez ID: 54344
|
Does Knockout of CAPZB in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
CAPZB
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: CAPZB (capping actin protein of muscle Z-line subunit beta)
Type: protein-coding
Summary: This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013].
Gene Ontology: BP: actin cytoskeleton organization, actin filament capping, actin polymerization or depolymerization, barbed-end actin filament capping, cell projection organization, cytoskeleton organization, lamellipodium assembly, regulation of cell morphogenesis; MF: actin binding, cadherin binding, protein binding; CC: F-actin capping protein complex, Schaffer collateral - CA1 synapse, WASH complex, actin cytoskeleton, asymmetric synapse, brush border, cortical cytoskeleton, cytoplasm, cytoskeleton, cytosol, extracellular exosome, hippocampal mossy fiber to CA3 synapse, lamellipodium, membrane, postsynaptic density, sarcomere, sperm head-tail coupling apparatus
Pathways: Adaptive Immune System, Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Endocytosis - Homo sapiens (human), Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport to the Golgi and subsequent modification, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport
UniProt: P47756
Entrez ID: 832
|
Does Knockout of LDAH in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
LDAH
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: LDAH (lipid droplet associated hydrolase)
Type: protein-coding
Summary: Predicted to enable lipase activity. Predicted to be involved in lipid storage. Predicted to be located in endoplasmic reticulum. Predicted to be active in lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cholesterol homeostasis, intracellular triglyceride homeostasis, lipid catabolic process, lipid droplet fusion, lipid metabolic process, lipid storage; MF: hydrolase activity, lipase activity, sterol ester esterase activity; CC: endoplasmic reticulum, lipid droplet
Pathways:
UniProt: Q9H6V9
Entrez ID: 60526
|
Does Knockout of NUTM2G in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
NUTM2G
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: NUTM2G (NUT family member 2G)
Type: protein-coding
Summary: NUT family member 2G
Gene Ontology:
Pathways:
UniProt: Q5VZR2
Entrez ID: 441457
|
Does Knockout of CSTF1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
CSTF1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CSTF1 (cleavage stimulation factor subunit 1)
Type: protein-coding
Summary: This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mRNA 3'-end processing, mRNA processing; MF: RNA binding, protein binding; CC: mRNA cleavage stimulating factor complex, nucleoplasm, nucleus
Pathways: BARD1 signaling events, Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human), polyadenylation of mrna
UniProt: Q05048
Entrez ID: 1477
|
Does Knockout of RAB6A in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
RAB6A
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RAB6A (RAB6A, member RAS oncogene family)
Type: protein-coding
Summary: This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: antigen processing and presentation, early endosome to Golgi transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, minus-end-directed organelle transport along microtubule, neuron projection development, peptidyl-cysteine methylation, protein localization to Golgi apparatus, protein localization to Golgi membrane, protein transport, retrograde transport, endosome to Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: GTP binding, GTPase activity, hydrolase activity, myosin V binding, nucleotide binding, protein binding, protein domain specific binding; CC: Golgi apparatus, Golgi membrane, acrosomal membrane, ciliary basal body, cytoplasmic vesicle, cytosol, endomembrane system, endoplasmic reticulum membrane, endosome to plasma membrane transport vesicle, extracellular exosome, membrane, nucleoplasm, plasma membrane, secretory granule membrane, trans-Golgi network, trans-Golgi network membrane
Pathways:
UniProt: P20340
Entrez ID: 5870
|
Does Knockout of KCNIP4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
KCNIP4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: KCNIP4 (potassium voltage-gated channel interacting protein 4)
Type: protein-coding
Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein localization to plasma membrane, regulation of potassium ion transmembrane transport, regulation of signal transduction; MF: calcium ion binding, metal ion binding, potassium channel activity, potassium channel regulator activity, protein binding; CC: cytoplasm, cytosol, endoplasmic reticulum, membrane, monoatomic ion channel complex, peroxisome, plasma membrane, voltage-gated potassium channel complex
Pathways: Cardiac conduction, Muscle contraction, Phase 1 - inactivation of fast Na+ channels, Regulation of nuclear beta catenin signaling and target gene transcription
UniProt: Q6PIL6
Entrez ID: 80333
|
Does Knockout of TBC1D17 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
TBC1D17
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: TBC1D17 (TBC1 domain family member 17)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Involved in retrograde transport, endosome to Golgi. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagy, protein transport, regulation of cilium assembly, retrograde transport, endosome to Golgi; MF: GTPase activator activity, protein binding; CC: autophagosome, cytoplasm, cytoplasmic vesicle, cytosol, endosome, recycling endosome
Pathways: Membrane Trafficking, Mitophagy - animal - Homo sapiens (human), Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q9HA65
Entrez ID: 79735
|
Does Knockout of LGALS8 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
LGALS8
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: LGALS8 (galectin 8)
Type: protein-coding
Summary: This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell costimulation, autophagy, cellular response to virus, lymphatic endothelial cell migration, plasma cell differentiation, xenophagy; MF: carbohydrate binding, integrin binding, protein binding; CC: cytoplasm, cytoplasmic vesicle, cytosol, extracellular space, membrane
Pathways:
UniProt: O00214
Entrez ID: 3964
|
Does Knockout of ITM2C in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
ITM2C
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ITM2C (integral membrane protein 2C)
Type: protein-coding
Summary: Enables amyloid-beta binding activity. Involved in negative regulation of neuron projection development and neuron differentiation. Located in several cellular components, including Golgi apparatus; lysosome; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of amyloid precursor protein biosynthetic process, negative regulation of neuron projection development, neuron differentiation, positive regulation of extrinsic apoptotic signaling pathway; MF: ATP binding, amyloid-beta binding, protein binding; CC: Golgi apparatus, extracellular exosome, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: IL-18 signaling pathway
UniProt: Q9NQX7
Entrez ID: 81618
|
Does Knockout of PITX2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
PITX2
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: PITX2 (paired like homeodomain 2)
Type: protein-coding
Summary: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Wnt signaling pathway, anatomical structure morphogenesis, animal organ morphogenesis, atrial cardiac muscle tissue morphogenesis, atrioventricular valve development, branching involved in blood vessel morphogenesis, camera-type eye development, cardiac muscle cell differentiation, cardiac muscle tissue development, cardiac neural crest cell migration involved in outflow tract morphogenesis, cell proliferation involved in outflow tract morphogenesis, deltoid tuberosity development, determination of left/right symmetry, digestive system development, embryonic camera-type eye development, embryonic digestive tract morphogenesis, embryonic heart tube left/right pattern formation, embryonic hindlimb morphogenesis, endodermal digestive tract morphogenesis, extraocular skeletal muscle development, hair cell differentiation, heart development, hypothalamus cell migration, in utero embryonic development, iris morphogenesis, left lung morphogenesis, left/right axis specification, lung development, negative regulation of transcription by RNA polymerase II, neuron migration, odontogenesis, outflow tract morphogenesis, pituitary gland development, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, prolactin secreting cell differentiation, pulmonary myocardium development, pulmonary vein morphogenesis, regulation of DNA-templated transcription, regulation of cell migration, regulation of cell population proliferation, regulation of transcription by RNA polymerase II, skeletal muscle tissue development, somatotropin secreting cell differentiation, spleen development, subthalamic nucleus development, superior vena cava morphogenesis, system development, vascular associated smooth muscle cell differentiation, vasculogenesis, ventricular cardiac muscle cell development, ventricular septum morphogenesis; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, identical protein binding, phosphoprotein binding, protein binding, protein homodimerization activity, ribonucleoprotein complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus, transcription regulator complex
Pathways: 22q11.2 copy number variation syndrome, BMP Signaling Pathway in Eyelid Development, Heart Development, Mesodermal commitment pathway, Regulation of nuclear beta catenin signaling and target gene transcription, TGF-beta signaling pathway - Homo sapiens (human), multi-step regulation of transcription by pitx2
UniProt: Q99697
Entrez ID: 5308
|
Does Knockout of ZNF407 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
ZNF407
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ZNF407 (zinc finger protein 407)
Type: protein-coding
Summary: This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptional regulation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: MF: DNA binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q9C0G0
Entrez ID: 55628
|
Does Knockout of MED11 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
MED11
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MED11 (mediator complex subunit 11)
Type: protein-coding
Summary: MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II; MF: protein binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Infectious disease, Metabolism, Metabolism of lipids, PPARA activates gene expression, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9P086
Entrez ID: 400569
|
Does Knockout of GOLGA6D in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
GOLGA6D
|
response to virus
|
Hepatoma Cell Line
|
Gene: GOLGA6D (golgin A6 family member D)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi cis cisterna; Golgi cisterna membrane; and cis-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Golgi apparatus, Golgi cis cisterna, Golgi cisterna membrane, cis-Golgi network
Pathways:
UniProt: P0CG33
Entrez ID: 653643
|
Does Knockout of ANXA11 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
ANXA11
|
cell proliferation
|
Bladder Carcinoma
|
Gene: ANXA11 (annexin A11)
Type: protein-coding
Summary: This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: cell division, cytokinetic process, phagocytosis, response to calcium ion; MF: MHC class II protein complex binding, RNA binding, S100 protein binding, calcium ion binding, calcium-dependent phospholipid binding, calcium-dependent protein binding, phosphatidylethanolamine binding, phosphatidylserine binding, protein binding; CC: azurophil granule, cytoplasm, cytoskeleton, cytosol, extracellular exosome, extracellular matrix, melanosome, membrane, midbody, nuclear envelope, nucleoplasm, nucleus, phagocytic vesicle, plasma membrane, specific granule, spindle, vesicle membrane
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), TCR
UniProt: P50995
Entrez ID: 311
|
Does Knockout of ANGPTL5 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
ANGPTL5
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: ANGPTL5 (angiopoietin like 5)
Type: protein-coding
Summary: Predicted to be active in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: Q86XS5
Entrez ID: 253935
|
Does Knockout of TLCD2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
TLCD2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: TLCD2 (TLC domain containing 2)
Type: protein-coding
Summary: Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: membrane assembly, phospholipid homeostasis, plasma membrane organization, regulation of membrane lipid distribution; CC: membrane, plasma membrane
Pathways:
UniProt: A6NGC4
Entrez ID: 727910
|
Does Knockout of MED10 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
MED10
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: MED10 (mediator complex subunit 10)
Type: protein-coding
Summary: MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance; MF: protein binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9BTT4
Entrez ID: 84246
|
Does Knockout of PGD in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
PGD
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PGD (phosphogluconate dehydrogenase)
Type: protein-coding
Summary: 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: D-gluconate metabolic process, NADP+ metabolic process, NADPH regeneration, pentose biosynthetic process, pentose-phosphate shunt, pentose-phosphate shunt, oxidative branch; MF: NADP binding, carbohydrate binding, carboxylic acid binding, oxidoreductase activity, phosphogluconate dehydrogenase (decarboxylating) activity; CC: cytoplasm, cytosol, extracellular exosome, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Glutathione metabolism - Homo sapiens (human), KEAP1-NFE2L2 pathway, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, NFE2L2 regulates pentose phosphate pathway genes, NRF2 pathway, Nuclear Receptors Meta-Pathway, Nuclear events mediated by NFE2L2, Pentose Phosphate Metabolism, Pentose phosphate pathway, Pentose phosphate pathway - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, Warburg Effect, pentose phosphate pathway, pentose phosphate pathway (oxidative branch)
UniProt: P52209
Entrez ID: 5226
|
Does Activation of FAM163A in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
FAM163A
|
protein/peptide accumulation
|
T cell
|
Gene: FAM163A (family with sequence similarity 163 member A)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q96GL9
Entrez ID: 148753
|
Does Knockout of AGBL1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
AGBL1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: AGBL1 (AGBL carboxypeptidase 1)
Type: protein-coding
Summary: Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013].
Gene Ontology: BP: C-terminal protein deglutamylation, protein side chain deglutamylation, proteolysis; MF: carboxypeptidase activity, hydrolase activity, metal ion binding, metallocarboxypeptidase activity, metallopeptidase activity, peptidase activity, tubulin binding, zinc ion binding; CC: cytoplasm, cytosol, microtubule cytoskeleton
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: Q96MI9
Entrez ID: 123624
|
Does Knockout of MST1 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
MST1
|
response to chemicals
|
Melanoma Cell Line
|
Gene: MST1 (macrophage stimulating 1)
Type: protein-coding
Summary: The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010].
Gene Ontology: BP: negative regulation of gluconeogenesis, proteolysis, regulation of cAMP-dependent protein kinase activity, regulation of macromolecule metabolic process, regulation of receptor signaling pathway via JAK-STAT; MF: endopeptidase activity, protein binding, receptor tyrosine kinase binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Calcium signaling pathway - Homo sapiens (human), FoxO family signaling, Hippo-Merlin Signaling Dysregulation, Hippo-Yap signaling pathway, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Overview of leukocyte-intrinsic Hippo pathway functions, Pathways Regulating Hippo Signaling, Signal Transduction, Signaling by MST1, Signaling by Receptor Tyrosine Kinases, a6b1 and a6b4 Integrin signaling, amb2 Integrin signaling
UniProt: P26927
Entrez ID: 4485
|
Does Knockout of WDR5 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
WDR5
|
cell proliferation
|
T-lymphoma cell line
|
Gene: WDR5 (WD repeat domain 5)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin organization, gluconeogenesis, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gluconeogenesis, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II, skeletal system development, transcription initiation-coupled chromatin remodeling; MF: histone H3K4 methyltransferase activity, histone H3K4me1 reader activity, histone H3Q5ser reader activity, histone binding, protein binding; CC: ATAC complex, MLL1 complex, MLL1/2 complex, MLL3/4 complex, NSL complex, Set1C/COMPASS complex, histone acetyltransferase complex, histone methyltransferase complex, mitotic spindle, nucleoplasm, nucleus
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Adaptive Immune System, Cardiogenesis, Chromatin modifying enzymes, Chromatin organization, Circadian rhythm pathway, Co-inhibition by PD-1, Cushing syndrome - Homo sapiens (human), Developmental Biology, Disease, Disorders of Developmental Biology, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, Immune System, Loss of Function of KMT2D in Kabuki Syndrome, Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism of proteins, Neddylation, PKMTs methylate histone lysines, Post-translational protein modification, RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Transcriptional regulation by RUNX1
UniProt: P61964
Entrez ID: 11091
|
Does Knockout of PPIL6 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
PPIL6
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PPIL6 (peptidylprolyl isomerase like 6)
Type: protein-coding
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: peptidyl-prolyl cis-trans isomerase activity, protein binding
Pathways:
UniProt: Q8IXY8
Entrez ID: 285755
|
Does Knockout of MRPL54 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
MRPL54
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: MRPL54 (mitochondrial ribosomal protein L54)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q6P161
Entrez ID: 116541
|
Does Knockout of PRY2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
PRY2
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: PRY2 (PTPN13 like Y-linked 2)
Type: ncRNA
Summary: This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Two nearly identical copies of this gene exist within a palindromic region. This record represents the more centromeric copy. [provided by RefSeq, Aug 2024].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 442862
|
Does Knockout of LARGE2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
LARGE2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: LARGE2 (LARGE xylosyl- and glucuronyltransferase 2)
Type: protein-coding
Summary: Predicted to enable dystroglycan binding activity; glucuronosyltransferase activity; and xylosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: muscle cell cellular homeostasis, protein O-linked glycosylation, protein O-linked glycosylation via mannose, protein glycosylation; MF: UDP-xylosyltransferase activity, catalytic activity, glucuronosyltransferase activity, glycosyltransferase activity, manganese ion binding, metal ion binding, protein binding, transferase activity, xylosyltransferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: DAG1 glycosylations, Mannose type O-glycan biosynthesis - Homo sapiens (human), Matriglycan biosynthesis on DAG1, Metabolism of proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8N3Y3
Entrez ID: 120071
|
Does Knockout of ACTR1B in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
ACTR1B
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: ACTR1B (actin related protein 1B)
Type: protein-coding
Summary: This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008].
Gene Ontology: MF: ATP binding, nucleotide binding, protein binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, dynactin complex, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, microtubule organizing center, secretory granule lumen
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Immune System, Innate Immune System, MHC class II antigen presentation, Neutrophil degranulation, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Salmonella infection - Homo sapiens (human)
UniProt: P42025
Entrez ID: 10120
|
Does Knockout of MAPK1 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
MAPK1
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: MAPK1 (mitogen-activated protein kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: B cell receptor signaling pathway, Bergmann glial cell differentiation, DNA damage response, ERBB signaling pathway, ERBB2-ERBB3 signaling pathway, ERK1 and ERK2 cascade, MAPK cascade, Schwann cell development, T cell receptor signaling pathway, animal organ morphogenesis, apoptotic process, cardiac neural crest cell development involved in heart development, caveolin-mediated endocytosis, cell surface receptor signaling pathway, cellular response to amino acid starvation, cellular response to tumor necrosis factor, chemical synaptic transmission, chemokine-mediated signaling pathway, chemotaxis, cytosine metabolic process, epidermal growth factor receptor signaling pathway, face development, heart development, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, interleukin-34-mediated signaling pathway, intracellular signal transduction, labyrinthine layer blood vessel development, learning or memory, lipopolysaccharide-mediated signaling pathway, long-term synaptic potentiation, lung morphogenesis, mammary gland epithelial cell proliferation, myelination, negative regulation of cell differentiation, neural crest cell development, outer ear morphogenesis, peptidyl-threonine phosphorylation, positive regulation of cholesterol biosynthetic process, positive regulation of macrophage chemotaxis, positive regulation of macrophage proliferation, positive regulation of neuroinflammatory response, positive regulation of peptidyl-threonine phosphorylation, positive regulation of telomere maintenance, protein phosphorylation, regulation of Golgi inheritance, regulation of cellular pH, regulation of cytoskeleton organization, regulation of early endosome to late endosome transport, regulation of ossification, regulation of protein stability, regulation of stress-activated MAPK cascade, regulation of transcription by RNA polymerase II, response to epidermal growth factor, response to exogenous dsRNA, response to lipopolysaccharide, response to nicotine, signal transduction, stress-activated MAPK cascade, thymus development, thyroid gland development, trachea formation; MF: ATP binding, DNA binding, MAP kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, identical protein binding, kinase activity, nucleotide binding, phosphatase binding, phosphotyrosine residue binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, anchoring junction, azurophil granule lumen, caveola, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, early endosome, endoplasmic reticulum lumen, extracellular region, ficolin-1-rich granule lumen, focal adhesion, late endosome, membrane, microtubule cytoskeleton, mitochondrion, mitotic spindle, nucleoplasm, nucleus, plasma membrane, pseudopodium, spindle, synapse
Pathways: 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression, AGE-RAGE pathway, AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), ALK1 signaling events, ATF-2 transcription factor network, Activation of NMDA receptors and postsynaptic events, Activation of the AP-1 family of transcription factors, Acute myeloid leukemia - Homo sapiens (human), Acute viral myocarditis, Adherens junction - Homo sapiens (human), Adherens junctions interactions, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Advanced glycosylation endproduct receptor signaling, Alcoholism - Homo sapiens (human), Aldosterone-regulated sodium reabsorption - Homo sapiens (human), Alpha 6 Beta 4 signaling pathway, Alpha6Beta4Integrin, Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Angiogenesis, Angiopoietin Like Protein 8 Regulatory Pathway, Angiopoietin receptor Tie2-mediated signaling, Apelin signaling pathway - Homo sapiens (human), Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis-related network due to altered Notch3 in ovarian cancer, Apoptotic factor-mediated response, Arf6 downstream pathway, Aryl Hydrocarbon Receptor Netpath, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Autophagy - animal - Homo sapiens (human), Axon guidance, Axon guidance - Homo sapiens (human), B Cell Receptor Signaling Pathway, B cell receptor signaling pathway - Homo sapiens (human), BCR, BCR signaling pathway, BDNF, BDNF-TrkB Signaling, BMP receptor signaling, Bacterial Infection Pathways, Bile acids synthesis and enterohepatic circulation, Bladder cancer, Bladder cancer - Homo sapiens (human), Brain-derived neurotrophic factor (BDNF) signaling pathway, Breast cancer - Homo sapiens (human), Breast cancer pathway, C-type lectin receptor signaling pathway - Homo sapiens (human), CAMKK2 Pathway, CDC42 signaling events, CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling, CRH, CXCR3-mediated signaling events, Ca-dependent events, Cardiac Hypertrophic Response, Cell Cycle, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cellular roles of Anthrax toxin, Cellular senescence - Homo sapiens (human), Central carbon metabolism in cancer - Homo sapiens (human), Ceramide signaling pathway, Chagas disease - Homo sapiens (human), Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Choline metabolism in cancer - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Chromosomal and microsatellite instability in colorectal cancer, Chronic myeloid leukemia - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Class IB PI3K non-lipid kinase events, Colorectal cancer - Homo sapiens (human), Common Pathways Underlying Drug Addiction, Coronavirus disease - COVID-19 - Homo sapiens (human), Corticotropin-releasing hormone signaling pathway, Cushing syndrome - Homo sapiens (human), Cytochrome c-mediated apoptotic response, Cytokine Signaling in Immune system, DNA damage response (only ATM dependent), Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disruption of postsynaptic signaling by CNV, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Downstream signaling in naïve CD8+ T cells, EGF-EGFR signaling pathway, EGFR Tyrosine Kinase Inhibitor Resistance, EGFR1, EPHB forward signaling, EPO Receptor Signaling, ERK Pathway in Huntington,s Disease, ERK/MAPK targets, ERKs are inactivated, ESC Pluripotency Pathways, ESR-mediated signaling, Ebola Virus Pathway on Host, Ebstein-Barr virus LMP1 signaling, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Endothelin Pathways, Endothelins, Envelope proteins and their potential roles in EDMD physiopathology, Epithelial to mesenchymal transition in colorectal cancer, ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), ErbB1 downstream signaling, ErbB2/ErbB3 signaling events, ErbB4 signaling events, Estrogen signaling pathway, Estrogen signaling pathway - Homo sapiens (human), Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Estrogen-stimulated signaling through PRKCZ, Extra-nuclear estrogen signaling, FBXL10 enhancement of MAP-ERK signaling in diffuse large B-cell lymphoma, FCERI mediated MAPK activation, FCGR3A-mediated phagocytosis, FGF signaling pathway, FGFR3 signaling in chondrocyte proliferation and terminal differentiation, Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fc-epsilon receptor I signaling in mast cells, Fcgamma receptor (FCGR) dependent phagocytosis, Fibroblast growth factor-1, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Follicle Stimulating Hormone (FSH) signaling pathway, Formation of apoptosome, FoxO signaling pathway - Homo sapiens (human), Fragile X Syndrome, Frs2-mediated activation, G alpha (i) signalling events, G alpha (q) signalling events, G-protein mediated events, GMCSF-mediated signaling events, GPCR downstream signalling, Gap junction - Homo sapiens (human), Gastric cancer - Homo sapiens (human), Gastrin, Gastrin signaling pathway, Gastrin-CREB signalling pathway via PKC and MAPK, Gene expression (Transcription), Generic Transcription Pathway, Ghrelin, Glioblastoma signaling pathways, Glioma - Homo sapiens (human), Glucocorticoid receptor regulatory network, Glutamatergic synapse - Homo sapiens (human), GnRH secretion - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Golgi Cisternae Pericentriolar Stack Reorganization, Growth hormone receptor signaling, Growth hormone synthesis, secretion and action - Homo sapiens (human), HIF-1 signaling pathway - Homo sapiens (human), Heart Development, Hemostasis, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Host-pathogen interaction of human coronaviruses - MAPK signaling, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Hypothesized Pathways in Pathogenesis of Cardiovascular Disease, ID, IFN-gamma pathway, IFNG signaling activates MAPKs, IL-1 signaling pathway, IL-17 signaling pathway - Homo sapiens (human), IL-18 signaling pathway, IL-2 signaling pathway, IL-3 signaling pathway, IL-4 signaling pathway, IL-5 signaling pathway, IL-6 signaling pathway, IL-7, IL-7 signaling pathway, IL-9 signaling pathway, IL1, IL11, IL17 signaling pathway, IL2, IL2-mediated signaling events, IL3, IL4, IL6, IL9, Immune System, Infection with Mycobacterium tuberculosis, Infectious disease, Influenza A - Homo sapiens (human), Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells, Innate Immune System, Insulin Signaling, Insulin Signalling, Insulin receptor signalling cascade, Insulin signaling pathway - Homo sapiens (human), Integrated breast cancer pathway, Integrin-mediated Cell Adhesion, Integrins in angiogenesis, Interferon Signaling, Interferon gamma signaling, Interleukin-11 Signaling Pathway, Interleukin-17 signaling, Intracellular Signalling Through Adenosine Receptor A2a and Adenosine, Intracellular Signalling Through Adenosine Receptor A2b and Adenosine, Intracellular signaling by second messengers, Intrinsic Pathway for Apoptosis, Kallmann,s Syndrome, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Kisspeptin-kisspeptin receptor system in the ovary, Kit receptor signaling pathway, KitReceptor, L1CAM interactions, Leishmania infection, Leishmania phagocytosis, Leishmaniasis - Homo sapiens (human), Leptin, Leptin signaling pathway, Lipid and atherosclerosis - Homo sapiens (human), Long-term depression - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), M Phase, MAP kinase activation, MAP kinase cascade, MAP2K and MAPK activation, MAP3K1 role in promoting and blocking gonadal determination, MAPK Cascade, MAPK Signaling Pathway, MAPK and NFkB signaling pathways inhibited by Yersinia YopJ, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK targets/ Nuclear events mediated by MAP kinases, MAPK1 (ERK2) activation, MAPK1/MAPK3 signaling, MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement, MFAP5-mediated ovarian cancer cell motility and invasiveness, MITF-M-regulated melanocyte development, Melanogenesis - Homo sapiens (human), Melanoma, Melanoma - Homo sapiens (human), MicroRNAs in cancer - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, Mitotic Prophase, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NCAM signaling for neurite out-growth, NOD-like receptor signaling pathway - Homo sapiens (human), NPAS4 regulates expression of target genes, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Negative Regulation of CDH1 Gene Transcription, Negative feedback regulation of MAPK pathway, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of MAPK pathway, Negative regulation of the PI3K/AKT network, Neovascularisation processes, Nervous system development, Netrin-UNC5B signaling pathway, Netrin-mediated signaling events, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neurotrophic factor-mediated Trk receptor signaling, Neurotrophin signaling pathway - Homo sapiens (human), Neutrophil degranulation, Neutrophil extracellular trap formation - Homo sapiens (human), Non-genomic actions of 1,25 dihydroxyvitamin D3, Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Nongenotropic Androgen signaling, Notch, Nuclear Events (kinase and transcription factor activation), Nuclear events stimulated by ALK signaling in cancer, Oncogene Induced Senescence, Oncogenic MAPK signaling, Oncostatin M Signaling Pathway, Oncostatin_M, Oocyte meiosis - Homo sapiens (human), Opioid Signalling, Osteoblast differentiation, Osteoclast differentiation - Homo sapiens (human), Osteopontin Signaling, Osteopontin-mediated events, Oxidative Stress Induced Senescence, Oxytocin signaling pathway - Homo sapiens (human), PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), PDGF Pathway, PDGFR-beta signaling pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PLC beta mediated events, PTEN Regulation, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Paradoxical activation of RAF signaling by kinase inactive BRAF, Parasite infection, Parasitic Infection Pathways, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Pertussis - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Physiological and pathological hypertrophy of the heart, Platelet activation - Homo sapiens (human), Platelet activation, signaling and aggregation, Post NMDA receptor activation events, Presenilin action in Notch and Wnt signaling, Prion disease - Homo sapiens (human), Prion disease pathway, Progesterone-mediated oocyte maturation - Homo sapiens (human), Programmed Cell Death, Prolactin, Prolactin Signaling Pathway, Prolactin signaling pathway - Homo sapiens (human), Prolonged ERK activation events, Prostate cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, RAGE, RANKL-RANK signaling pathway, RAS and bradykinin pathways in COVID-19, RHO GTPase Effectors, RHO GTPases Activate NADPH Oxidases, RHO GTPases Activate WASPs and WAVEs, RNA Polymerase II Transcription, RSK activation, RUNX2 regulates bone development, RUNX2 regulates osteoblast differentiation, Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling in the CD4+ TCR pathway, Ras signaling pathway - Homo sapiens (human), Recycling pathway of L1, Regucalcin in proximal tubule epithelial kidney cells, Regulation of Actin Cytoskeleton, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of HSF1-mediated heat shock response, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PTEN gene transcription, Regulation of Telomerase, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Regulation of cytoplasmic and nuclear SMAD2/3 signaling, Regulation of the apoptosome activity, Regulation of toll-like receptor signaling pathway, Regulatory circuits of the STAT3 signaling pathway, Relationship between inflammation, COX-2 and EGFR, Relaxin signaling pathway - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), Resistin as a regulator of inflammation, Response of Mtb to phagocytosis, Retinoic acid receptors-mediated signaling, Retrograde endocannabinoid signaling - Homo sapiens (human), S1P1 pathway, S1P2 pathway, S1P3 pathway, S1P4 pathway, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Salmonella infection - Homo sapiens (human), Senescence and Autophagy in Cancer, Senescence-Associated Secretory Phenotype (SASP), Serotonergic synapse - Homo sapiens (human), Serotonin Receptor 2 and ELK-SRF-GATA4 signaling, Serotonin Receptor 4-6-7 and NR3C Signaling, Shigellosis - Homo sapiens (human), Signal Transduction, Signal Transduction of S1P Receptor, Signal attenuation, Signal transduction by L1, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Activin, Signaling by BRAF and RAF1 fusions, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by LTK in cancer, Signaling by MAP2K mutants, Signaling by MAPK mutants, Signaling by NODAL, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Nuclear Receptors, Signaling by RAF1 mutants, Signaling by RAS mutants, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by high-kinase activity BRAF mutants, Signaling by moderate kinase activity BRAF mutants, Signaling downstream of RAS mutants, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by PRL, Signaling events mediated by VEGFR1 and VEGFR2, Signaling events mediated by focal adhesion kinase, Signaling events regulated by Ret tyrosine kinase, Signaling of Hepatocyte Growth Factor Receptor, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Signalling to ERKs, Sphingolipid signaling pathway - Homo sapiens (human), Spinal Cord Injury, Spry regulation of FGF signaling, Structural Pathway of Interleukin 1 (IL-1), Suppression of apoptosis, Synaptic signaling pathways associated with autism spectrum disorder, Syndecan-1-mediated signaling events, Syndecan-2-mediated signaling events, T cell receptor signaling pathway - Homo sapiens (human), T-cell receptor (TCR) signaling pathway, TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer, TCR, TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, TGF-beta Signaling Pathway, TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, TNF signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, TNFalpha, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAIL signaling pathway, TRIF (TICAM1)-mediated TLR4 signaling , TSLP, TWEAK, Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Thrombin signalling through proteinase activated receptors (PARs), Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, Thyroid cancer - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid stimulating hormone (TSH) signaling pathway, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like Receptor Signaling Pathway, Toll-like Receptor Signaling related to MyD88, Toll-like receptor signaling pathway - Homo sapiens (human), Toxoplasmosis - Homo sapiens (human), Transcriptional Regulation by NPAS4, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional regulation by RUNX2, Translation inhibitors in chronically activated PDGFRA cells, Transmission across Chemical Synapses, Trk receptor signaling mediated by the MAPK pathway, Tuberculosis - Homo sapiens (human), Type II diabetes mellitus, Type II diabetes mellitus - Homo sapiens (human), VEGF signaling pathway - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, VEGFR1 specific signals, VEGFR3 signaling in lymphatic endothelium, Vascular smooth muscle contraction - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), Vitamin A and carotenoid metabolism, Wnt Signaling Pathway, Yersinia infection - Homo sapiens (human), agrin in postsynaptic differentiation, angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling, aspirin blocks signaling pathway involved in platelet activation, bioactive peptide induced signaling pathway, cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human), cadmium induces dna synthesis and proliferation in macrophages, ccr3 signaling in eosinophils, ceramide signaling pathway, erk and pi-3 kinase are necessary for collagen binding in corneal epithelia, erk1/erk2 mapk signaling pathway, fc epsilon receptor i signaling in mast cells, fmlp induced chemokine gene expression in hmc-1 cells, how progesterone initiates the oocyte maturation, human cytomegalovirus and map kinase pathways, il-2 receptor beta chain in t cell activation, influence of ras and rho proteins on g1 to s transition, keratinocyte differentiation, links between pyk2 and map kinases, mTOR signaling pathway, mTOR signaling pathway - Homo sapiens (human), mapkinase signaling pathway, mcalpain and friends in cell motility, mechanism of gene regulation by peroxisome proliferators via ppara, melanocyte development and pigmentation pathway, phospho-PLA2 pathway, phospholipids as signalling intermediaries, phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway, regulation of eif-4e and p70s6 kinase, regulation of splicing through sam68, role of -arrestins in the activation and targeting of map kinases, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, role of erbb2 in signal transduction and oncology, role of erk5 in neuronal survival pathway, role of mal in rho-mediated activation of srf, roles of arrestin dependent recruitment of src kinases in gpcr signaling, sprouty regulation of tyrosine kinase signals, stat3 signaling pathway, transcription factor creb and its extracellular signals, trefoil factors initiate mucosal healing
UniProt: P28482
Entrez ID: 5594
|
Does Knockout of PDCL3 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
PDCL3
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: PDCL3 (phosducin like 3)
Type: protein-coding
Summary: This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin cytoskeleton organization, angiogenesis, apoptotic process, negative regulation of protein folding, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of angiogenesis, positive regulation of endothelial cell proliferation, positive regulation of gene expression, protein folding, protein stabilization, regulation of peptidyl-tyrosine phosphorylation; MF: protein binding, protein folding chaperone, vascular endothelial growth factor receptor 2 binding; CC: cytoplasm, cytosol, endoplasmic reticulum, nucleoplasm, perinuclear region of cytoplasm, perinucleolar compartment, protein-containing complex
Pathways:
UniProt: Q9H2J4
Entrez ID: 79031
|
Does Knockout of FGF8 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
FGF8
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: FGF8 (fibroblast growth factor 8)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, anatomical structure morphogenesis, aorta morphogenesis, apoptotic process, blood vessel remodeling, bone development, branching involved in blood vessel morphogenesis, branching involved in salivary gland morphogenesis, branching involved in ureteric bud morphogenesis, cell differentiation, cell fate commitment, cell migration involved in mesendoderm migration, cell population proliferation, cell proliferation in forebrain, central nervous system neuron development, corticotropin hormone secreting cell differentiation, determination of left/right symmetry, dopaminergic neuron differentiation, dorsal/ventral axon guidance, dorsal/ventral pattern formation, embryo development ending in birth or egg hatching, embryonic heart tube development, embryonic hindlimb morphogenesis, embryonic neurocranium morphogenesis, epithelial to mesenchymal transition involved in endocardial cushion formation, fibroblast growth factor receptor signaling pathway, forebrain dorsal/ventral pattern formation, forebrain morphogenesis, forebrain neuron development, gastrulation, generation of neurons, gonad development, heart development, heart looping, heart morphogenesis, inner ear morphogenesis, kidney development, larynx morphogenesis, limb morphogenesis, lung development, lung morphogenesis, male genitalia development, mesodermal cell migration, mesonephros development, metanephros development, midbrain-hindbrain boundary development, mitotic nuclear division, motor neuron axon guidance, negative regulation of apoptotic process, negative regulation of cardiac muscle tissue development, negative regulation of neuron apoptotic process, neural plate morphogenesis, neuroepithelial cell differentiation, neurogenesis, neuron apoptotic process, odontogenesis, organ growth, organ induction, otic vesicle formation, outflow tract morphogenesis, outflow tract septum morphogenesis, pallium development, pharyngeal system development, positive chemotaxis, positive regulation of ERK1 and ERK2 cascade, positive regulation of G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of cell differentiation, positive regulation of cell division, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of mitotic nuclear division, positive regulation of organ growth, positive regulation of stem cell proliferation, regulation of cell migration, regulation of odontogenesis of dentin-containing tooth, response to oxidative stress, response to xenobiotic stimulus, signal transduction, signal transduction involved in regulation of gene expression, stem cell proliferation, subpallium development, telencephalon development, thyroid gland development, thyroid-stimulating hormone-secreting cell differentiation; MF: chemoattractant activity, growth factor activity, type 1 fibroblast growth factor receptor binding, type 2 fibroblast growth factor receptor binding; CC: cytoplasm, external side of plasma membrane, extracellular region, extracellular space
Pathways: 22q11.2 copy number variation syndrome, Activated point mutants of FGFR2, Breast cancer - Homo sapiens (human), Breast cancer pathway, Calcium signaling pathway - Homo sapiens (human), Constitutive Signaling by Aberrant PI3K in Cancer, Differentiation Pathway, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dopaminergic Neurogenesis, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, ESC Pluripotency Pathways, FGFR1 ligand binding and activation, FGFR1 mutant receptor activation, FGFR1c ligand binding and activation, FGFR2 ligand binding and activation, FGFR2 mutant receptor activation, FGFR2c ligand binding and activation, FGFR3 ligand binding and activation, FGFR3 mutant receptor activation, FGFR3b ligand binding and activation, FGFR3c ligand binding and activation, FGFR4 ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Gastric cancer - Homo sapiens (human), Gene regulatory network modelling somitogenesis, Genes controlling nephrogenesis, Heart Development, IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, Kallmann,s Syndrome, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, Melanoma - Homo sapiens (human), Mesodermal commitment pathway, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, Neural Crest Differentiation, Osteoblast differentiation, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Homo sapiens (human), Phospholipase C-mediated cascade: FGFR1, Phospholipase C-mediated cascade; FGFR2, Phospholipase C-mediated cascade; FGFR3, Phospholipase C-mediated cascade; FGFR4, RAF/MAP kinase cascade, Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR1, Signaling by FGFR1 in disease, Signaling by FGFR2, Signaling by FGFR2 in disease, Signaling by FGFR3, Signaling by FGFR3 in disease, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by activated point mutants of FGFR1, Signaling by activated point mutants of FGFR3, Tgif disruption of Shh signaling
UniProt: P55075
Entrez ID: 2253
|
Does Knockout of FBXO16 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
FBXO16
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: FBXO16 (F-box protein 16)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology:
Pathways:
UniProt: Q8IX29
Entrez ID: 157574
|
Does Knockout of MPHOSPH10 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
MPHOSPH10
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: MPHOSPH10 (M-phase phosphoprotein 10)
Type: protein-coding
Summary: This gene encodes a protein that is phosphorylated during mitosis. The protein localizes to the nucleolus during interphase and to the chromosomes during M phase. The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: RNA processing, RNA splicing, RNA splicing, via transesterification reactions, maturation of SSU-rRNA, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding; CC: Mpp10 complex, chromosome, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, small-subunit processome, sno(s)RNA-containing ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O00566
Entrez ID: 10199
|
Does Knockout of CTDSPL2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
CTDSPL2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CTDSPL2 (CTD small phosphatase like 2)
Type: protein-coding
Summary: Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to act upstream of or within negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; and protein dephosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of BMP signaling pathway, positive regulation of protein export from nucleus, protein export from nucleus, regulation of transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat phosphatase activity, hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q05D32
Entrez ID: 51496
|
Does Knockout of DNAL4 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
DNAL4
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: DNAL4 (dynein axonemal light chain 4)
Type: protein-coding
Summary: This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: microtubule-based movement, microtubule-based process; MF: identical protein binding, microtubule motor activity, protein binding; CC: cell projection, cilium, cytoplasm, cytoskeleton, dynein complex, microtubule, plasma membrane
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Retrograde neurotrophin signalling, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases
UniProt: O96015
Entrez ID: 10126
|
Does Knockout of KRT85 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
KRT85
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: KRT85 (keratin 85)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: epidermis development, intermediate filament organization, keratinization; MF: protein binding, structural constituent of skin epidermis, structural molecule activity; CC: cytosol, extracellular space, intermediate filament, keratin filament
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: P78386
Entrez ID: 3891
|
Does Knockout of UBAC1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
UBAC1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: UBAC1 (UBA domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in protein ubiquitination. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein maturation, protein ubiquitination; MF: polyubiquitin modification-dependent protein binding, proteasome binding, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, extracellular exosome, plasma membrane, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q9BSL1
Entrez ID: 10422
|
Does Knockout of STK11 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
STK11
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: STK11 (serine/threonine kinase 11)
Type: protein-coding
Summary: The protein encoded by this gene is a serine/threonine kinase that regulates cell polarity and energy metabolism and functions as a tumor suppressor. Mutations in this gene have been associated with the autosomal dominant Peutz-Jeghers syndrome, as well as with skin, pancreatic, and testicular cancers. [provided by RefSeq, May 2022].
Gene Ontology: BP: DNA damage response, G1 to G0 transition, Golgi localization, T cell receptor signaling pathway, activation of protein kinase activity, anoikis, apoptotic process, autophagy, axonogenesis, cell differentiation, cellular response to UV-B, dendrite extension, epithelial cell proliferation involved in prostate gland development, establishment of cell polarity, glucose homeostasis, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of TORC1 signaling, negative regulation of canonical Wnt signaling pathway, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of cold-induced thermogenesis, negative regulation of epithelial cell proliferation involved in prostate gland development, peptidyl-threonine phosphorylation, positive regulation of autophagy, positive regulation of axonogenesis, positive regulation of protein localization to nucleus, positive regulation of transforming growth factor beta receptor signaling pathway, positive regulation of vesicle transport along microtubule, positive thymic T cell selection, protein autophosphorylation, protein dephosphorylation, protein localization to nucleus, protein phosphorylation, regulation of Wnt signaling pathway, regulation of cell cycle, regulation of cell growth, regulation of dendrite morphogenesis, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of signal transduction by p53 class mediator, response to ionizing radiation, signal transduction, spermatogenesis, tissue homeostasis, vasculature development; MF: ATP binding, LRR domain binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, p53 binding, protein binding, protein kinase activator activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centrosome, cilium, cytoplasm, cytosol, extracellular exosome, intracellular protein-containing complex, membrane, mitochondrion, nucleoplasm, nucleus, serine/threonine protein kinase complex
Pathways: AMP-activated protein kinase (AMPK) signaling, AMPK inhibits chREBP transcriptional activation activity, AMPK signaling pathway - Homo sapiens (human), ATM Signaling Network in Development and Disease, Adipocytokine signaling pathway - Homo sapiens (human), Autophagy - animal - Homo sapiens (human), EGFR1, Energy dependent regulation of mTOR by LKB1-AMPK, FOXO-mediated transcription, FOXO-mediated transcription of cell death genes, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, FoxO signaling pathway - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, Head and Neck Squamous Cell Carcinoma, Integrated breast cancer pathway, Integration of energy metabolism, LKB1 signaling events, Longevity regulating pathway - Homo sapiens (human), MTOR signalling, Metabolism, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Signal Transduction, TGF_beta_Receptor, Tight junction - Homo sapiens (human), Transcriptional Regulation by TP53, mTOR signaling pathway - Homo sapiens (human), mir-124 predicted interactions with cell cycle and differentiation
UniProt: Q15831
Entrez ID: 6794
|
Does Knockout of PFDN6 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
PFDN6
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: PFDN6 (prefoldin subunit 6)
Type: protein-coding
Summary: PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010].
Gene Ontology: BP: chaperone-mediated protein complex assembly, negative regulation of amyloid fibril formation, protein folding, protein stabilization; MF: amyloid-beta binding, protein binding, protein-folding chaperone binding, unfolded protein binding; CC: RPAP3/R2TP/prefoldin-like complex, cytoplasm, prefoldin complex, protein folding chaperone complex, protein-containing complex
Pathways: Cellular Proteostasis, Chaperonin-mediated protein folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Metabolism of proteins, Prefoldin mediated transfer of substrate to CCT/TriC, Protein folding
UniProt: O15212
Entrez ID: 10471
|
Does Knockout of CNOT7 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
CNOT7
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CNOT7 (CCR4-NOT transcription complex subunit 7)
Type: protein-coding
Summary: The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016].
Gene Ontology: BP: P-body assembly, deadenylation-dependent decapping of nuclear-transcribed mRNA, defense response to virus, miRNA-mediated gene silencing by mRNA destabilization, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of type I interferon-mediated signaling pathway, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, nuclear-transcribed mRNA poly(A) tail shortening, piRNA-mediated gene silencing by mRNA destabilization, positive regulation of cell population proliferation, positive regulation of mRNA catabolic process, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of transcription by RNA polymerase II, positive regulation of viral genome replication, regulation of translation, regulation of tyrosine phosphorylation of STAT protein, regulatory ncRNA-mediated gene silencing; MF: 3'-5'-RNA exonuclease activity, DNA-binding transcription factor binding, RNA binding, RNA exonuclease activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, piRNA binding, poly(A)-specific ribonuclease activity, protein binding, transcription corepressor activity; CC: CCR4-NOT complex, CCR4-NOT core complex, P-body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, membrane, nuclear body, nuclear speck, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Developmental Biology, Gene expression (Transcription), Generic Transcription Pathway, M-decay: degradation of maternal mRNAs by maternally stored factors, Maternal to zygotic transition (MZT), Metabolism of RNA, RNA Polymerase II Transcription, RNA degradation - Homo sapiens (human), TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: Q9UIV1
Entrez ID: 29883
|
Does Knockout of ZNF207 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
ZNF207
|
cell proliferation
|
Bladder Carcinoma
|
Gene: ZNF207 (zinc finger protein 207)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in several processes, including mitotic nuclear division; mitotic spindle assembly checkpoint signaling; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, microtubule bundle formation, microtubule polymerization, mitotic sister chromatid segregation, mitotic spindle assembly, mitotic spindle assembly checkpoint signaling, protein stabilization, regulation of chromosome segregation; MF: DNA binding, RNA binding, heparin binding, metal ion binding, microtubule binding, protein binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleolus, nucleoplasm, nucleus, spindle, spindle matrix
Pathways:
UniProt: O43670
Entrez ID: 7756
|
Does Knockout of ATF4 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
ATF4
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: ATF4 (activating transcription factor 4)
Type: protein-coding
Summary: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: GDF15-GFRAL signaling pathway, HRI-mediated signaling, L-asparagine metabolic process, PERK-mediated unfolded protein response, bone mineralization, cellular response to UV, cellular response to amino acid starvation, cellular response to glucose starvation, cellular response to hypoxia, cellular response to leucine starvation, cellular response to oxidative stress, circadian regulation of gene expression, circadian rhythm, embryonic hemopoiesis, endoplasmic reticulum unfolded protein response, gamma-aminobutyric acid signaling pathway, gluconeogenesis, integrated stress response signaling, intracellular calcium ion homeostasis, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, lens fiber cell morphogenesis, mRNA transcription by RNA polymerase II, mitochondrial respirasome assembly, negative regulation of cold-induced thermogenesis, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of potassium ion transport, negative regulation of transcription by RNA polymerase II, negative regulation of translational initiation in response to stress, neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of biomineral tissue development, positive regulation of gene expression, positive regulation of neuron apoptotic process, positive regulation of sodium-dependent phosphate transport, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular endothelial growth factor production, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of osteoblast differentiation, regulation of synaptic plasticity, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to manganese-induced endoplasmic reticulum stress, response to nutrient levels, response to toxic substance, rhythmic process, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding protein binding, general transcription initiation factor binding, identical protein binding, leucine zipper domain binding, promoter-specific chromatin binding, protein binding, protein heterodimerization activity, protein kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: ATF1-ATF4 transcription factor complex, ATF4-CREB1 transcription factor complex, CHOP-ATF4 complex, Lewy body core, RNA polymerase II transcription regulator complex, centrosome, chromatin, cytoplasm, cytoskeleton, cytosol, dendrite membrane, membrane, mitochondrion, neuron projection, nuclear periphery, nuclear speck, nucleoplasm, nucleus, plasma membrane, protein-containing complex, transcription regulator complex
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, ATF6 (ATF6-alpha) activates chaperone genes, ATF6 (ATF6-alpha) activates chaperones, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alcoholism - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Amphetamine addiction - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis - Homo sapiens (human), Cellular response to chemical stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Cholinergic synapse - Homo sapiens (human), Cocaine addiction - Homo sapiens (human), Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Dopaminergic synapse - Homo sapiens (human), Estrogen signaling pathway - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glucagon signaling pathway - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Joubert Syndrome, KEAP1-NFE2L2 pathway, Lipid and atherosclerosis - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), Longevity regulating pathway - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mitophagy - animal - Homo sapiens (human), Myometrial relaxation and contraction pathways, NFE2L2 regulating ER-stress associated genes, NFE2L2 regulating anti-oxidant/detoxification enzymes, Neurotrophin signaling pathway - Homo sapiens (human), Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Nuclear events mediated by NFE2L2, PERK regulates gene expression, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Photodynamic therapy-induced unfolded protein response, Prion disease - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Renin-angiotensin-aldosterone system (RAAS), Response of EIF2AK1 (HRI) to heme deficiency, Response of EIF2AK4 (GCN2) to amino acid deficiency, TNF signaling pathway - Homo sapiens (human), Thyroid hormone synthesis - Homo sapiens (human), Unfolded Protein Response (UPR), Unfolded protein response, VEGFA-VEGFR2 Signaling Pathway, Validated transcriptional targets of AP1 family members Fra1 and Fra2, Viral carcinogenesis - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P18848
Entrez ID: 468
|
Does Knockout of EHD3 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
EHD3
|
cell proliferation
|
Cancer Cell Line
|
Gene: EHD3 (EH domain containing 3)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity. Involved in several processes, including Golgi to lysosome transport; endosomal transport; and protein homooligomerization. Acts upstream of or within protein localization to plasma membrane and regulation of cardiac muscle cell membrane potential. Located in ciliary pocket membrane and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Golgi to lysosome transport, cell projection organization, cilium assembly, early endosome to Golgi transport, endocytic recycling, endocytosis, protein homooligomerization, protein localization to plasma membrane, protein transport, receptor recycling, regulation of Golgi organization, regulation of cardiac conduction, regulation of cardiac muscle cell membrane potential, regulation of cardiac muscle contraction; MF: ATP binding, GTP binding, calcium ion binding, metal ion binding, nucleic acid binding, nucleotide binding, protein binding, protein-macromolecule adaptor activity; CC: cell projection, ciliary membrane, ciliary pocket membrane, cilium, cytoplasm, cytosol, early endosome, endocytic vesicle, endosome, endosome membrane, focal adhesion, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, recycling endosome membrane
Pathways: Ciliary landscape, Endocytosis - Homo sapiens (human), Factors involved in megakaryocyte development and platelet production, Hemostasis
UniProt: Q9NZN3
Entrez ID: 30845
|
Does Knockout of DSG3 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
DSG3
|
cell proliferation
|
Cancer Cell Line
|
Gene: DSG3 (desmoglein 3)
Type: protein-coding
Summary: This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: actin filament organization, adherens junction assembly, cell adhesion, cell-cell adhesion, desmosome assembly, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of cell migration, negative regulation of p38MAPK cascade, positive regulation of bicellular tight junction assembly, positive regulation of protein localization to adherens junction, positive regulation of protein localization to membrane, regulation of protein stability, tight junction assembly; MF: calcium ion binding, metal ion binding, protein binding, protein dimerization activity; CC: anchoring junction, bicellular tight junction, cell junction, cell-cell junction, cornified envelope, cytoplasm, cytosol, desmosome, extracellular exosome, membrane, plasma membrane, tight junction
Pathways:
UniProt: P32926
Entrez ID: 1830
|
Does Knockout of TAF1B in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
TAF1B
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: TAF1B (TATA-box binding protein associated factor, RNA polymerase I subunit B)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: DNA-templated transcription, RNA polymerase I preinitiation complex assembly, nucleolar large rRNA transcription by RNA polymerase I, transcription by RNA polymerase I; MF: DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, TBP-class protein binding, metal ion binding, protein binding, zinc ion binding; CC: RNA polymerase I core factor complex, RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, Rett syndrome causing genes, SIRT1 negatively regulates rRNA expression
UniProt: Q53T94
Entrez ID: 9014
|
Does Knockout of NCBP3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
NCBP3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NCBP3 (nuclear cap binding subunit 3)
Type: protein-coding
Summary: Enables RNA 7-methylguanosine cap binding activity and mRNA binding activity. Involved in defense response to virus. Located in cytoplasm and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 7-methylguanosine mRNA capping, defense response to virus, mRNA export from nucleus, mRNA processing, mRNA transcription by RNA polymerase II, mRNA transport, regulatory ncRNA-mediated post-transcriptional gene silencing, snRNA export from nucleus; MF: RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, mRNA binding, protein binding; CC: RNA cap binding complex, cytoplasm, nuclear cap binding complex, nuclear speck, nucleus
Pathways:
UniProt: Q53F19
Entrez ID: 55421
|
Does Knockout of CDCA3 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
CDCA3
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: CDCA3 (cell division cycle associated 3)
Type: protein-coding
Summary: Predicted to be involved in cell division and protein ubiquitination. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, protein ubiquitination; CC: adherens junction, cytoplasm, cytosol
Pathways:
UniProt: Q99618
Entrez ID: 83461
|
Does Knockout of C20orf144 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 1
| 1,480
|
Knockout
|
C20orf144
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: C20orf144 (chromosome 20 open reading frame 144)
Type: protein-coding
Summary: chromosome 20 open reading frame 144
Gene Ontology:
Pathways:
UniProt: Q9BQM9
Entrez ID: 128864
|
Does Knockout of SMG1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
SMG1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SMG1 (SMG1 nonsense mediated mRNA decay associated PI3K related kinase)
Type: protein-coding
Summary: This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: DNA damage response, DNA repair, mRNA export from nucleus, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, peptidyl-serine phosphorylation, phosphatidylinositol phosphate biosynthetic process, protein autophosphorylation, regulation of telomere maintenance; MF: ATP binding, RNA binding, diacylglycerol-dependent serine/threonine kinase activity, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, telomeric DNA binding, transferase activity; CC: chromatoid body, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q96Q15
Entrez ID: 23049
|
Does Knockout of CCR5 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
CCR5
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: CCR5 (C-C motif chemokine receptor 5)
Type: protein-coding
Summary: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, MAPK cascade, apoptotic process, calcium ion transport, calcium-mediated signaling, cell chemotaxis, cell surface receptor signaling pathway, cell-cell signaling, cellular defense response, cellular response to cytokine stimulus, cellular response to lipopolysaccharide, chemokine-mediated signaling pathway, chemotaxis, defense response, dendritic cell chemotaxis, immune response, inflammatory response, negative regulation of macrophage apoptotic process, positive regulation of cytosolic calcium ion concentration, release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, response to cholesterol, signal transduction, signaling, symbiont entry into host cell; MF: C-C chemokine binding, C-C chemokine receptor activity, G protein-coupled receptor activity, actin binding, chemokine (C-C motif) ligand 5 binding, chemokine receptor activity, coreceptor activity, identical protein binding, phosphatidylinositol-4,5-bisphosphate phospholipase C activity, protein binding, virus receptor activity; CC: cell surface, cytoplasm, endosome, external side of plasma membrane, membrane, plasma membrane
Pathways: -arrestins in gpcr desensitization, Acute viral myocarditis, Binding and entry of HIV virion, Chemokine receptors bind chemokines, Chemokine signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Disease, Early Phase of HIV Life Cycle, Endocytosis - Homo sapiens (human), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, GPCRs, Other, HIV Infection, HIV Life Cycle, Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), IL12-mediated signaling events, Immune System, Infectious disease, Interleukin-10 signaling, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Peptide GPCRs, Peptide ligand-binding receptors, Selective expression of chemokine receptors during T-cell polarization, Signal Transduction, Signaling by GPCR, Signaling by Interleukins, T-cell receptor (TCR) signaling pathway, Toxoplasmosis - Homo sapiens (human), Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human), activation of camp-dependent protein kinase pka, activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor, chrebp regulation by carbohydrates and camp, il12 and stat4 dependent signaling pathway in th1 development, ion channels and their functional role in vascular endothelium, pertussis toxin-insensitive ccr5 signaling in macrophage, role of -arrestins in the activation and targeting of map kinases, roles of arrestin dependent recruitment of src kinases in gpcr signaling
UniProt: P51681
Entrez ID: 1234
|
Does Knockout of GLCCI1 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
GLCCI1
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: GLCCI1 (glucocorticoid induced 1)
Type: protein-coding
Summary: This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012].
Gene Ontology:
Pathways:
UniProt: Q86VQ1
Entrez ID: 113263
|
Does Knockout of TSFM in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
TSFM
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: TSFM (Ts translation elongation factor, mitochondrial)
Type: protein-coding
Summary: This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010].
Gene Ontology: BP: mitochondrial translational elongation, translation, translational elongation; MF: RNA binding, protein binding, translation elongation factor activity; CC: intracellular organelle lumen, mitochondrion, nucleoplasm
Pathways: Metabolism of proteins, Mitochondrial translation, Mitochondrial translation elongation, Translation
UniProt: P43897
Entrez ID: 10102
|
Does Knockout of GPX4 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
GPX4
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: GPX4 (glutathione peroxidase 4)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. [provided by RefSeq, Dec 2018].
Gene Ontology: BP: apoptotic process, arachidonate metabolic process, cellular oxidant detoxification, cerebellum development, chromatin organization, dendrite development, lipid metabolic process, lipoxygenase pathway, long-chain fatty acid biosynthetic process, multicellular organism growth, negative regulation of ferroptosis, phospholipid metabolic process, protein polymerization, response to estradiol, response to lipopolysaccharide, response to oxidative stress, spermatogenesis; MF: glutathione peroxidase activity, identical protein binding, oxidoreductase activity, peroxidase activity, phospholipid-hydroperoxide glutathione peroxidase activity, protein binding, selenium binding; CC: cytoplasm, cytosol, extracellular exosome, mitochondrion, nuclear envelope, nucleus, protein-containing complex
Pathways: Biosynthesis of D-series resolvins, Biosynthesis of DHA-derived SPMs, Biosynthesis of E-series 18(R)-resolvins, Biosynthesis of E-series 18(S)-resolvins, Biosynthesis of EPA-derived SPMs, Biosynthesis of aspirin-triggered D-series resolvins, Biosynthesis of specialized proresolving mediators (SPMs), Ferroptosis, Ferroptosis - Homo sapiens (human), Folate Metabolism, Glutathione metabolism, Glutathione metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, Metapathway biotransformation Phase I and II, One-carbon metabolism and related pathways, Selenium Micronutrient Network, glutathione redox reactions I
UniProt: P36969
Entrez ID: 2879
|
Does Knockout of SAE1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
SAE1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SAE1 (SUMO1 activating enzyme subunit 1)
Type: protein-coding
Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010].
Gene Ontology: BP: positive regulation of protein sumoylation, positive regulation of protein targeting to mitochondrion, protein sumoylation, protein ubiquitination; MF: ATP-dependent protein binding, SUMO activating enzyme activity, enzyme activator activity, ligase activity, protein binding, protein heterodimerization activity, small protein activating enzyme binding, ubiquitin activating enzyme activity, ubiquitin-like modifier activating enzyme activity; CC: SUMO activating enzyme complex, cytoplasm, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, SUMO is conjugated to E1 (UBA2:SAE1), SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, Ubiquitin mediated proteolysis - Homo sapiens (human), basic mechanisms of sumoylation, er associated degradation (erad) pathway
UniProt: Q9UBE0
Entrez ID: 10055
|
Does Knockout of PTMS in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
PTMS
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: PTMS (parathymosin)
Type: protein-coding
Summary: Predicted to be involved in DNA replication. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA replication, immune system process, negative regulation of apoptotic process, positive regulation of transcription by RNA polymerase II; CC: nucleus
Pathways: IL-18 signaling pathway
UniProt: P20962
Entrez ID: 5763
|
Does Knockout of SLC2A1 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
SLC2A1
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: SLC2A1 (solute carrier family 2 member 1)
Type: protein-coding
Summary: This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: D-glucose import, D-glucose import across plasma membrane, D-glucose transmembrane transport, L-ascorbic acid metabolic process, cellular hyperosmotic response, cellular response to glucose starvation, cellular response to mechanical stimulus, central nervous system development, cerebral cortex development, dehydroascorbic acid transport, female pregnancy, fucose transmembrane transport, long-chain fatty acid import across plasma membrane, photoreceptor cell maintenance, protein-containing complex assembly, response to Thyroglobulin triiodothyronine, response to hypoxia, response to insulin, transmembrane transport, transport across blood-brain barrier, xenobiotic transport; MF: D-glucose transmembrane transporter activity, dehydroascorbic acid transmembrane transporter activity, fucose transmembrane transporter activity, identical protein binding, kinase binding, long-chain fatty acid transmembrane transporter activity, protein binding, transmembrane transporter activity, xenobiotic transmembrane transporter activity; CC: Golgi membrane, Z disc, apical plasma membrane, basolateral plasma membrane, blood microparticle, caveola, cell-cell junction, cortical actin cytoskeleton, cytoplasm, cytosol, extracellular exosome, female germ cell nucleus, female pronucleus, glucose transporter complex, intercalated disc, melanosome, membrane, membrane raft, midbody, photoreceptor inner segment, plasma membrane, presynapse, sarcolemma, synapse, vesicle
Pathways: Adipocytokine signaling pathway - Homo sapiens (human), Angiopoietin Like Protein 8 Regulatory Pathway, Bile secretion - Homo sapiens (human), Cellular hexose transport, Central carbon metabolism in cancer - Homo sapiens (human), Computational Model of Aerobic Glycolysis, Congenital disorder of glycosylation CDG-IId, Cori Cycle, Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1), Diabetic cardiomyopathy - Homo sapiens (human), Disease, Disorders of transmembrane transporters, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, GLUT-1 deficiency syndrome, Glucagon signaling pathway - Homo sapiens (human), Glycolysis and Gluconeogenesis, HIF-1 signaling pathway - Homo sapiens (human), HIF-1-alpha transcription factor network, HIF-2-alpha transcription factor network, HIF1A and PPARG regulation of glycolysis, Human T-cell leukemia virus 1 infection - Homo sapiens (human), IL3, Insulin Signaling, Insulin resistance - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Integration of energy metabolism, Lactose Synthesis, Lactose synthesis, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, NAD Metabolism in Oncogene-Induced Senescence and Mitochondrial Dysfunction-Associated Senescence, NRF2 pathway, Nuclear Receptors Meta-Pathway, Pathways in cancer - Homo sapiens (human), Pathways in clear cell renal cell carcinoma, Photodynamic therapy-induced HIF-1 survival signaling, Proximal tubule transport, Regulation of insulin secretion, Renal cell carcinoma - Homo sapiens (human), SLC transporter disorders, SLC-mediated transmembrane transport, Thyroid hormone signaling pathway - Homo sapiens (human), Transport of small molecules, Type 2 papillary renal cell carcinoma, Validated targets of C-MYC transcriptional activation, Vitamin C (ascorbate) metabolism, p53 transcriptional gene network
UniProt: P11166
Entrez ID: 6513
|
Does Knockout of RNPS1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
RNPS1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: RNPS1 (RNA binding protein with serine rich domain 1)
Type: protein-coding
Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].
Gene Ontology: BP: DNA-templated transcription, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, negative regulation of mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of apoptotic process, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA 3'-UTR binding, nucleic acid binding, protein binding; CC: ASAP complex, cytoplasm, cytosol, exon-exon junction complex, nuclear speck, nucleoplasm, nucleus
Pathways: RNA transport - Homo sapiens (human), mRNA Processing, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q15287
Entrez ID: 10921
|
Does Knockout of ARFRP1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
ARFRP1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ARFRP1 (ARF related protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012].
Gene Ontology: BP: Golgi to plasma membrane protein transport, gastrulation, intracellular protein transport, protein localization to Golgi apparatus, retrograde transport, endosome to Golgi, signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding; CC: Golgi apparatus, cytosol, membrane, trans-Golgi network, trans-Golgi network membrane
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q13795
Entrez ID: 10139
|
Does Knockout of RPL5 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
RPL5
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RPL5 (ribosomal protein L5)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18P family of ribosomal proteins and component of the 60S subunit. The encoded protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The encoded protein may also function to inhibit tumorigenesis through the activation of downstream tumor suppressors and the downregulation of oncoprotein expression. Mutations in this gene have been identified in patients with Diamond-Blackfan Anemia (DBA). This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: cytoplasmic translation, negative regulation of protein neddylation, negative regulation of ubiquitin protein ligase activity, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of gene expression, positive regulation of translation, protein stabilization, rRNA processing, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosomal large subunit biogenesis, translation; MF: 5S rRNA binding, RNA binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, protein binding, rRNA binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, VEGFA-VEGFR2 Signaling Pathway, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, p53 pathway, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46777
Entrez ID: 6125
|
Does Knockout of RACGAP1 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
RACGAP1
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: RACGAP1 (Rac GTPase activating protein 1)
Type: protein-coding
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: Rho protein signal transduction, actomyosin contractile ring assembly, cell differentiation, cell division, erythrocyte differentiation, mitotic cytokinesis, mitotic spindle midzone assembly, monoatomic ion transport, neuroblast proliferation, positive regulation of cytokinesis, regulation of attachment of spindle microtubules to kinetochore, regulation of embryonic development, regulation of small GTPase mediated signal transduction, signal transduction, spermatogenesis, sulfate transmembrane transport; MF: GTPase activator activity, alpha-tubulin binding, beta-tubulin binding, gamma-tubulin binding, lipid binding, metal ion binding, microtubule binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding, protein kinase binding, protein-macromolecule adaptor activity, zinc ion binding; CC: Flemming body, acrosomal vesicle, centralspindlin complex, cleavage furrow, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, cytosol, extracellular exosome, membrane, microtubule, midbody, mitochondrion, mitotic spindle, nucleoplasm, nucleus, plasma membrane, spindle, spindle midzone
Pathways: Adaptive Immune System, Aurora B signaling, CDC42 GTPase cycle, COPI-dependent Golgi-to-ER retrograde traffic, EGFR1, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, RAC1 GTPase cycle, RAC1 signaling pathway, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, Regulation of CDC42 activity, Regulation of RAC1 activity, Signal Transduction, Signal Transduction of S1P Receptor, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport, Wnt signaling pathway and pluripotency
UniProt: Q9H0H5
Entrez ID: 29127
|
Does Knockout of RAB10 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
RAB10
|
cell proliferation
|
Cancer Cell Line
|
Gene: RAB10 (RAB10, member RAS oncogene family)
Type: protein-coding
Summary: RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009].
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi to plasma membrane transport, antigen processing and presentation, axonogenesis, cell-cell adhesion, cellular response to insulin stimulus, endoplasmic reticulum tubular network organization, endosomal transport, establishment of neuroblast polarity, establishment of protein localization to endoplasmic reticulum membrane, establishment of protein localization to membrane, exocytosis, polarized epithelial cell differentiation, protein localization to basolateral plasma membrane, protein localization to plasma membrane, protein transport, regulated exocytosis, vesicle-mediated transport; MF: G protein activity, GDP binding, GTP binding, GTPase activity, cadherin binding involved in cell-cell adhesion, hydrolase activity, myosin V binding, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi membrane, adherens junction, cell projection, cilium, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, endosome, endosome membrane, exocyst, exocytic vesicle, extracellular exosome, focal adhesion, insulin-responsive compartment, lysosome, membrane, perinuclear region of cytoplasm, phagocytic vesicle membrane, plasma membrane, recycling endosome, recycling endosome membrane, secretory granule membrane, secretory vesicle, trans-Golgi network
Pathways: AMPK signaling pathway - Homo sapiens (human), Endocytosis - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Translocation of SLC2A4 (GLUT4) to the plasma membrane, Vesicle-mediated transport
UniProt: P61026
Entrez ID: 10890
|
Does Knockout of POLA2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
POLA2
|
cell proliferation
|
Cancer Cell Line
|
Gene: POLA2 (DNA polymerase alpha 2, accessory subunit)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Involved in DNA replication, synthesis of RNA primer. Located in cytosol and nucleoplasm. Part of alpha DNA polymerase:primase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA replication, DNA replication initiation, DNA replication, synthesis of primer, protein import into nucleus; MF: DNA binding, protein binding; CC: alpha DNA polymerase:primase complex, ciliary basal body, cytosol, nucleoplasm, nucleus
Pathways: Activation of the pre-replicative complex, Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA replication initiation, DNA strand elongation, Defective pyroptosis, Disease, Diseases of programmed cell death, E2F mediated regulation of DNA replication, Extension of Telomeres, G1 to S cell cycle control, G1/S Transition, Inhibition of replication initiation of damaged DNA by RB1/E2F1, Lagging Strand Synthesis, Leading Strand Synthesis, Mitotic G1 phase and G1/S transition, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the lagging strand, Pyrimidine metabolism, Removal of the Flap Intermediate, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: Q14181
Entrez ID: 23649
|
Does Knockout of RNF175 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
RNF175
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: RNF175 (ring finger protein 175)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding, ubiquitin protein ligase activity, zinc ion binding; CC: Golgi membrane, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q8N4F7
Entrez ID: 285533
|
Does Knockout of DAD1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
DAD1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: DAD1 (defender against cell death 1)
Type: protein-coding
Summary: DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, blastocyst development, negative regulation of apoptotic process, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, regulation of protein stability; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Asparagine N-linked glycosylation, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Disease, Immune System, Infectious disease, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Various types of N-glycan biosynthesis - Homo sapiens (human), Viral Infection Pathways
UniProt: P61803
Entrez ID: 1603
|
Does Knockout of LETM1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
LETM1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: LETM1 (leucine zipper and EF-hand containing transmembrane protein 1)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: calcium export from the mitochondrion, calcium ion transport, cristae formation, inner mitochondrial membrane organization, mitochondrial calcium ion homeostasis, mitochondrial calcium ion transmembrane transport, mitochondrial potassium ion transmembrane transport, mitochondrion organization, monoatomic ion transport, negative regulation of mitochondrial calcium ion concentration, potassium ion transport, protein hexamerization, protein homooligomerization, proton transmembrane transport, regulation of cellular hyperosmotic salinity response; MF: antiporter activity, calcium ion binding, calcium:proton antiporter activity, metal ion binding, protein binding, ribosome binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex III assembly, Metabolism, Mitochondrial calcium ion transport, RHO GTPase cycle, RHOG GTPase cycle, Respiratory electron transport, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport of small molecules
UniProt: O95202
Entrez ID: 3954
|
Does Knockout of TOM1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
TOM1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: TOM1 (target of myb1 membrane trafficking protein)
Type: protein-coding
Summary: This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: autophagosome-lysosome fusion, endocytosis, endosomal transport, positive regulation of autophagosome maturation, protein transport, regulation of endosome organization, signal transduction, substrate localization to autophagosome; MF: clathrin binding, clathrin heavy chain binding, myosin VI binding, phosphatidylinositol binding, phosphatidylinositol-5-phosphate binding, polyubiquitin modification-dependent protein binding, protein binding, ubiquitin binding; CC: Golgi apparatus, azurophil granule membrane, cytoplasm, cytosol, early endosome, early endosome membrane, endosome, endosome membrane, extracellular exosome, membrane, plasma membrane, specific granule membrane
Pathways: C-MYB transcription factor network, EGFR1
UniProt: O60784
Entrez ID: 10043
|
Does Activation of TAS2R50 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
TAS2R50
|
protein/peptide accumulation
|
T cell
|
Gene: TAS2R50 (taste 2 receptor member 50)
Type: protein-coding
Summary: TAS2R50 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). See also TAS2R10 (MIM 604791).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity; CC: membrane, plasma membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Signal Transduction, Signaling by GPCR, Taste transduction - Homo sapiens (human)
UniProt: P59544
Entrez ID: 259296
|
Does Knockout of SNRPE in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
SNRPE
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SNRPE (small nuclear ribonucleoprotein polypeptide E)
Type: protein-coding
Summary: The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2016].
Gene Ontology: BP: 7-methylguanosine cap hypermethylation, RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, spliceosomal complex assembly, spliceosomal snRNP assembly; MF: RNA binding, protein binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, pICln-Sm protein complex, precatalytic spliceosome, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex, telomerase holoenzyme complex
Pathways: Disease, Gene expression (Transcription), Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Homo sapiens (human), Viral Infection Pathways, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62304
Entrez ID: 6635
|
Does Knockout of FIG4 in Huh-7 Cell causally result in response to virus?
| 1
| 1,382
|
Knockout
|
FIG4
|
response to virus
|
Huh-7 Cell
|
Gene: FIG4 (FIG4 phosphoinositide 5-phosphatase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: locomotory behavior, myelin assembly, myelination, negative regulation of myelination, neuron development, phosphatidylinositol biosynthetic process, phosphatidylinositol dephosphorylation, phosphatidylinositol metabolic process, phosphatidylinositol-3-phosphate biosynthetic process, pigmentation, positive regulation of neuron projection development, vacuole organization; MF: hydrolase activity, phosphatase activity, phosphatidylinositol bisphosphate phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity, phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-3-phosphate phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, phosphatidylinositol-4-phosphate phosphatase activity, protein binding, protein serine/threonine phosphatase activity; CC: Golgi membrane, early endosome membrane, endosome, endosome membrane, intracellular membrane-bounded organelle, late endosome membrane, lipid droplet, membrane, recycling endosome
Pathways: 3-phosphoinositide biosynthesis, Amyotrophic lateral sclerosis - Homo sapiens (human), Inositol Metabolism, Inositol phosphate metabolism - Homo sapiens (human), Intracellular trafficking proteins involved in CMT neuropathy, Joubert syndrome, Metabolism, Metabolism of lipids, PI Metabolism, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phosphatidylinositol Phosphate Metabolism, Phospholipid metabolism, Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the late endosome membrane, superpathway of inositol phosphate compounds
UniProt: Q92562
Entrez ID: 9896
|
Does Knockout of KIN in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
KIN
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: KIN (Kin17 DNA and RNA binding protein)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA replication, mRNA processing; MF: DNA binding, RNA binding, double-stranded DNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol, nuclear matrix, nucleoplasm, nucleus, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Protein methylation
UniProt: O60870
Entrez ID: 22944
|
Does Knockout of GCSAML in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
GCSAML
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GCSAML (germinal center associated signaling and motility like)
Type: protein-coding
Summary: This gene encodes a protein thought to be a signaling molecule associated with germinal centers, the sites of proliferation and differentiation of mature B lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: regulation of B cell receptor signaling pathway, regulation of lymphocyte migration
Pathways:
UniProt: Q5JQS6
Entrez ID: 148823
|
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