prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Activation of CCDC158 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | CCDC158 | protein/peptide accumulation | T cell | Gene: CCDC158 (coiled-coil domain containing 158)
Type: protein-coding
Summary: coiled-coil domain containing 158
Gene Ontology: MF: clathrin binding, protein binding; CC: clathrin-coated vesicle, early endosome
Pathways:
UniProt: Q5M9N0
Entrez ID: 339965 |
Does Knockout of EFNB3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | EFNB3 | cell proliferation | Endometrial Cancer Cell Line | Gene: EFNB3 (ephrin B3)
Type: protein-coding
Summary: EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may p... |
Does Knockout of TPI1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | TPI1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: TPI1 (triosephosphate isomerase 1)
Type: protein-coding
Summary: This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gen... |
Does Knockout of FUT3 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | FUT3 | response to virus | Hepatoma Cell Line | Gene: FUT3 (fucosyltransferase 3 (Lewis blood group))
Type: protein-coding
Summary: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissu... |
Does Knockout of ALAS1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | ALAS1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ALAS1 (5'-aminolevulinate synthase 1)
Type: protein-coding
Summary: This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enz... |
Does Knockout of QPCTL in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | QPCTL | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: QPCTL (glutaminyl-peptide cyclotransferase like)
Type: protein-coding
Summary: Enables glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Acts upstream of or within peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase. Located in Golgi... |
Does Knockout of DTL in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | DTL | cell proliferation | Melanoma Cell Line | Gene: DTL (denticleless E3 ubiquitin protein ligase adapter)
Type: protein-coding
Summary: Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in ce... |
Does Knockout of RBBP8 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | RBBP8 | response to virus | Hepatoma Cell Line | Gene: RBBP8 (RB binding protein 8, endonuclease)
Type: protein-coding
Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with tr... |
Does Knockout of BUD13 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | BUD13 | cell proliferation | Monocytic Leukemia Cell Line | Gene: BUD13 (BUD13 spliceosome associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RN... |
Does Knockout of ZNF687 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | ZNF687 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ZNF687 (zinc finger protein 687)
Type: protein-coding
Summary: This gene encodes C2H2 zinc finger protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript... |
Does Knockout of TSR2 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | TSR2 | cell proliferation | Colonic Cancer Cell Line | Gene: TSR2 (TSR2 ribosome maturation factor)
Type: protein-coding
Summary: The protein encoded by this gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. [provided by RefSeq, Oct 2016].
Gene Ontol... |
Does Knockout of GOSR2 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | GOSR2 | cell proliferation | Gastric Cancer Cell Line | Gene: GOSR2 (golgi SNAP receptor complex member 2)
Type: protein-coding
Summary: This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial esse... |
Does Knockout of CDCA8 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | CDCA8 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CDCA8 (cell division cycle associated 8)
Type: protein-coding
Summary: This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule sta... |
Does Knockout of THOC3 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | THOC3 | cell proliferation | Glioblastoma Cell Line | Gene: THOC3 (THO complex subunit 3)
Type: protein-coding
Summary: This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export compl... |
Does Knockout of SDC1 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | SDC1 | cell proliferation | Melanoma Cell Line | Gene: SDC1 (syndecan 1)
Type: protein-coding
Summary: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors ar... |
Does Knockout of C20orf96 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | C20orf96 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: C20orf96 (chromosome 20 open reading frame 96)
Type: protein-coding
Summary: chromosome 20 open reading frame 96
Gene Ontology:
Pathways:
UniProt: Q9NUD7
Entrez ID: 140680 |
Does Knockout of PSAT1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | PSAT1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: PSAT1 (phosphoserine aminotransferase 1)
Type: protein-coding
Summary: This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations i... |
Does Knockout of TRPV3 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | TRPV3 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: TRPV3 (transient receptor potential cation channel subfamily V member 3)
Type: protein-coding
Summary: This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of t... |
Does Knockout of C4orf17 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | C4orf17 | response to virus | Lung Cancer Cell Line | Gene: C4orf17 (chromosome 4 open reading frame 17)
Type: protein-coding
Summary: chromosome 4 open reading frame 17
Gene Ontology:
Pathways:
UniProt: Q53FE4
Entrez ID: 84103 |
Does Knockout of AQR in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | AQR | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: AQR (aquarius intron-binding spliceosomal factor)
Type: protein-coding
Summary: Enables 3'-5' RNA helicase activity and single-stranded RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of G... |
Does Knockout of TMTC1 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | TMTC1 | response to virus | Lung Cancer Cell Line | Gene: TMTC1 (transmembrane O-mannosyltransferase targeting cadherins 1)
Type: protein-coding
Summary: Enables mannosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. [provided by Alliance ... |
Does Knockout of ELP1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | ELP1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: ELP1 (elongator acetyltransferase complex subunit 1)
Type: protein-coding
Summary: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases... |
Does Knockout of CHD4 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | CHD4 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CHD4 (chromodomain helicase DNA binding protein 4)
Type: protein-coding
Summary: The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repre... |
Does Knockout of ASH2L in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | ASH2L | cell proliferation | Neuroblastoma Cell Line | Gene: ASH2L (ASH2 like, histone lysine methyltransferase complex subunit)
Type: protein-coding
Summary: Enables beta-catenin binding activity and transcription cis-regulatory region binding activity. Contributes to histone methyltransferase activity (H3-K4 specific). Involved in histone H3-K4 methylatio... |
Does Knockout of PROX1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | PROX1 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: PROX1 (prospero homeobox 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encod... |
Does Knockout of CEMIP in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | CEMIP | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: CEMIP (cell migration inducing hyaluronidase 1)
Type: protein-coding
Summary: Enables several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process;... |
Does Knockout of NLE1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | NLE1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: NLE1 (notchless homolog 1)
Type: protein-coding
Summary: Predicted to be involved in Notch signaling pathway and ribosomal large subunit assembly. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and regulation... |
Does Knockout of ATP6V0D1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | ATP6V0D1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ATP6V0D1 (ATPase H+ transporting V0 subunit d1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intr... |
Does Activation of ADAMTS16 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | ADAMTS16 | protein/peptide accumulation | T cell | Gene: ADAMTS16 (ADAM metallopeptidase with thrombospondin type 1 motif 16)
Type: protein-coding
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a pro... |
Does Knockout of SDF2L1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | SDF2L1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: SDF2L1 (stromal cell derived factor 2 like 1)
Type: protein-coding
Summary: Enables misfolded protein binding activity. Involved in chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum. Part of chaperone complex. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of KRT17 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | KRT17 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: KRT17 (keratin 17)
Type: protein-coding
Summary: This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma ... |
Does Knockout of RBM4B in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | RBM4B | cell proliferation | Mammary Gland Tumor Cell Line | Gene: RBM4B (RNA binding motif protein 4B)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in entrainment of circadian clock by photoperiod; mRNA splicing, via spliceosome; and regulation of gene expression. Predicted to act upstream of or within positive regulation ... |
Does Knockout of TMEM220 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | TMEM220 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: TMEM220 (transmembrane protein 220)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q6QAJ8
Entrez ID: 388335 |
Does Activation of CCNB1IP1 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | CCNB1IP1 | protein/peptide accumulation | T cell | Gene: CCNB1IP1 (cyclin B1 interacting protein 1)
Type: protein-coding
Summary: HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: blastocyst formation, chiasma assembly, meiotic cell ... |
Does Knockout of OLFML1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | OLFML1 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: OLFML1 (olfactomedin like 1)
Type: protein-coding
Summary: Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q6UWY5
Entrez ID: 283... |
Does Knockout of NUS1 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | NUS1 | cell proliferation | Cancer Cell Line | Gene: NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit)
Type: protein-coding
Summary: This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded pro... |
Does Knockout of HSPE1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | HSPE1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: HSPE1 (heat shock protein family E (Hsp10) member 1)
Type: protein-coding
Summary: This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodime... |
Does Knockout of CDC42SE1 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | CDC42SE1 | cell proliferation | Melanoma Cell Line | Gene: CDC42SE1 (CDC42 small effector 1)
Type: protein-coding
Summary: Predicted to enable GTPase inhibitor activity. Predicted to be involved in signal transduction. Located in cell junction. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: phagocytosis, regulation of Rho... |
Does Knockout of MFAP1 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | MFAP1 | cell proliferation | T-lymphoma cell line | Gene: MFAP1 (microfibril associated protein 1)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in centrosome; microfibril; and nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of NCAPH in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | NCAPH | cell proliferation | Multiple Myeloma Cell Line | Gene: NCAPH (non-SMC condensin I complex subunit H)
Type: protein-coding
Summary: This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by t... |
Does Knockout of FRRS1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | FRRS1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: FRRS1 (ferric chelate reductase 1)
Type: protein-coding
Summary: Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008].
... |
Does Knockout of OR5H14 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | OR5H14 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: OR5H14 (olfactory receptor family 5 subfamily H member 14)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of NMT1 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | NMT1 | cell proliferation | T-lymphoma cell line | Gene: NMT1 (N-myristoyltransferase 1)
Type: protein-coding
Summary: Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catal... |
Does Knockout of CXCL1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | CXCL1 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: CXCL1 (C-X-C motif chemokine ligand 1)
Type: protein-coding
Summary: This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflam... |
Does Knockout of OR4K2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | OR4K2 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: OR4K2 (olfactory receptor family 4 subfamily K member 2)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Activation of ARHGAP12 in T cell causally result in protein/peptide accumulation? | 1 | 2,425 | Activation | ARHGAP12 | protein/peptide accumulation | T cell | Gene: ARHGAP12 (Rho GTPase activating protein 12)
Type: protein-coding
Summary: This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasio... |
Does Knockout of MRPL12 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | MRPL12 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: MRPL12 (mitochondrial ribosomal protein L12)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of FPGT-TNNI3K in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | FPGT-TNNI3K | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: FPGT-TNNI3K (FPGT-TNNI3K readthrough)
Type: protein-coding
Summary: This locus represents naturally occurring read-through transcription from the neighboring fucose-1-phosphate guanylyltransferase (FPGT) and TNNI3 interacting kinase (TNNI3K) genes. Alternative splicing results in multiple transcri... |
Does Knockout of CDC26 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | CDC26 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: CDC26 (cell division cycle 26)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regul... |
Does Knockout of KANSL1L in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | KANSL1L | cell proliferation | Bladder Carcinoma | Gene: KANSL1L (KAT8 regulatory NSL complex subunit 1 like)
Type: protein-coding
Summary: Predicted to enable histone acetyltransferase binding activity. Predicted to be part of NSL complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: H4 histone acetyltransferase comp... |
Does Knockout of PRPF6 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | PRPF6 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: PRPF6 (pre-mRNA processing factor 6)
Type: protein-coding
Summary: The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, pr... |
Does Knockout of CD63 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | CD63 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: CD63 (CD63 molecule)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins... |
Does Knockout of NUP205 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | NUP205 | cell proliferation | Cancer Cell Line | Gene: NUP205 (nucleoporin 205)
Type: protein-coding
Summary: This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with ... |
Does Knockout of GNAS in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | GNAS | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: GNAS (GNAS complex locus)
Type: protein-coding
Summary: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a different... |
Does Knockout of SMIM24 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | SMIM24 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: SMIM24 (small integral membrane protein 24)
Type: protein-coding
Summary: Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: O75264
Entrez I... |
Does Knockout of NUP214 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | NUP214 | cell proliferation | T-lymphoma cell line | Gene: NUP214 (nucleoporin 214)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear po... |
Does Knockout of DPH5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | DPH5 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: DPH5 (diphthamide biosynthesis 5)
Type: protein-coding
Summary: This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is ... |
Does Knockout of ENO1 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | ENO1 | cell proliferation | Hepatoma Cell Line | Gene: ENO1 (enolase 1)
Type: protein-coding
Summary: This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structur... |
Does Knockout of B3GALT2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | B3GALT2 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: B3GALT2 (beta-1,3-galactosyltransferase 2)
Type: protein-coding
Summary: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose an... |
Does Knockout of HLA-DQA2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | HLA-DQA2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: HLA-DQA2 (major histocompatibility complex, class II, DQ alpha 2)
Type: protein-coding
Summary: This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the pept... |
Does Knockout of PLK1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | PLK1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: PLK1 (polo like kinase 1)
Type: protein-coding
Summary: The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically ... |
Does Knockout of GATB in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | GATB | cell proliferation | Melanoma Cell Line | Gene: GATB (glutamyl-tRNA amidotransferase subunit B)
Type: protein-coding
Summary: Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidot... |
Does Knockout of HOXA4 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | HOXA4 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: HOXA4 (homeobox A4)
Type: protein-coding
Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic... |
Does Knockout of EIF3F in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | EIF3F | cell proliferation | Medulloblastoma Cell Line | Gene: EIF3F (eukaryotic translation initiation factor 3 subunit F)
Type: protein-coding
Summary: Enables deubiquitinase activity and identical protein binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; protein deubiquitinat... |
Does Knockout of CHMP2A in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | CHMP2A | cell proliferation | Cancer Cell Line | Gene: CHMP2A (charged multivesicular body protein 2A)
Type: protein-coding
Summary: CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved i... |
Does Knockout of MALT1 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | MALT1 | cell proliferation | Gastric Cancer Cell Line | Gene: MALT1 (MALT1 paracaspase)
Type: protein-coding
Summary: This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following... |
Does Knockout of QRFPR in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | QRFPR | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: QRFPR (pyroglutamylated RFamide peptide receptor)
Type: protein-coding
Summary: Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in non-motile cilium. Predicted to be integral component of plasma membrane. [provided by A... |
Does Knockout of CHMP2A in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | CHMP2A | cell proliferation | Colonic Cancer Cell Line | Gene: CHMP2A (charged multivesicular body protein 2A)
Type: protein-coding
Summary: CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved i... |
Does Knockout of SLC4A1AP in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | SLC4A1AP | response to chemicals | Glioblastoma Cell Line | Gene: SLC4A1AP (solute carrier family 4 member 1 adaptor protein)
Type: protein-coding
Summary: Predicted to enable mRNA binding activity. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: mRNA binding, protein binding; CC: cytop... |
Does Knockout of FGFR3 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | FGFR3 | response to chemicals | Melanoma Cell Line | Gene: FGFR3 (fibroblast growth factor receptor 3)
Type: protein-coding
Summary: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another ... |
Does Knockout of LAMTOR3 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | LAMTOR3 | cell proliferation | Multiple Myeloma Cell Line | Gene: LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3)
Type: protein-coding
Summary: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding pr... |
Does Knockout of SPACA7 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | SPACA7 | cell proliferation | Glioblastoma Cell Line | Gene: SPACA7 (sperm acrosome associated 7)
Type: protein-coding
Summary: Predicted to act upstream of or within negative regulation of cell adhesion and single fertilization. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: acrosomal lumen, a... |
Does Knockout of KLHL31 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | KLHL31 | cell proliferation | Glioblastoma Cell Line | Gene: KLHL31 (kelch like family member 31)
Type: protein-coding
Summary: Involved in negative regulation of JNK cascade and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulati... |
Does Knockout of KCNS3 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | KCNS3 | cell proliferation | Astrocytoma Cell Line | Gene: KCNS3 (potassium voltage-gated channel modifier subfamily S member 3)
Type: protein-coding
Summary: Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the re... |
Does Knockout of DPPA4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | DPPA4 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: DPPA4 (developmental pluripotency associated 4)
Type: protein-coding
Summary: This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain... |
Does Knockout of SUPV3L1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | SUPV3L1 | cell proliferation | Endometrial Cancer Cell Line | Gene: SUPV3L1 (Suv3 like RNA helicase)
Type: protein-coding
Summary: Enables helicase activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including mitochondrial RNA metabolic process; mitochondrion morphogenesis; and positive regulation of mito... |
Does Knockout of SEPSECS in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | SEPSECS | cell proliferation | Cancer Cell Line | Gene: SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)
Type: protein-coding
Summary: The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein en... |
Does Knockout of DAD1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | DAD1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: DAD1 (defender against cell death 1)
Type: protein-coding
Summary: DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells f... |
Does Knockout of TBC1D3 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | TBC1D3 | response to chemicals | Monocytic Leukemia Cell Line | Gene: TBC1D3 (TBC1 domain family member 3)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in early endosome membrane. [provided by Alliance of Genome Resou... |
Does Knockout of NOC2L in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | NOC2L | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: NOC2L (NOC2 like nucleolar associated transcriptional repressor)
Type: protein-coding
Summary: Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of hi... |
Does Knockout of SUPV3L1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | SUPV3L1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SUPV3L1 (Suv3 like RNA helicase)
Type: protein-coding
Summary: Enables helicase activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including mitochondrial RNA metabolic process; mitochondrion morphogenesis; and positive regulation of mito... |
Does Knockout of KREMEN2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | KREMEN2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: KREMEN2 (kringle containing transmembrane protein 2)
Type: protein-coding
Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein f... |
Does Activation of KLHL31 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | KLHL31 | protein/peptide accumulation | T cell | Gene: KLHL31 (kelch like family member 31)
Type: protein-coding
Summary: Involved in negative regulation of JNK cascade and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulati... |
Does Knockout of CIAO1 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | CIAO1 | cell proliferation | Prostate Cancer Cell Line | Gene: CIAO1 (cytosolic iron-sulfur assembly component 1)
Type: protein-coding
Summary: Involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in cytoplasm. Part of CIA complex and MMXD complex. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of MPL in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | MPL | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: MPL (MPL proto-oncogene, thrombopoietin receptor)
Type: protein-coding
Summary: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named... |
Does Knockout of RANBP10 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | RANBP10 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: RANBP10 (RAN binding protein 10)
Type: protein-coding
Summary: RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN... |
Does Activation of GCLM in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | GCLM | protein/peptide accumulation | T cell | Gene: GCLM (glutamate-cysteine ligase modifier subunit)
Type: protein-coding
Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulat... |
Does Knockout of GJB7 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | GJB7 | response to chemicals | Colorectal Cancer Cell Line | Gene: GJB7 (gap junction protein beta 7)
Type: protein-coding
Summary: Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which... |
Does Knockout of SPATA19 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | SPATA19 | response to chemicals | Melanoma Cell Line | Gene: SPATA19 (spermatogenesis associated 19)
Type: protein-coding
Summary: Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation... |
Does Knockout of TGOLN2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | TGOLN2 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: TGOLN2 (trans-golgi network protein 2)
Type: protein-coding
Summary: This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golg... |
Does Knockout of SNAPC3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | SNAPC3 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: SNAPC3 (small nuclear RNA activating complex polypeptide 3)
Type: protein-coding
Summary: Predicted to enable RNA polymerase III type 3 promoter sequence-specific DNA binding activity and bent DNA binding activity. Predicted to contribute to RNA polymerase II cis-regulatory region sequence-specifi... |
Does Knockout of PLPBP in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | PLPBP | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: PLPBP (pyridoxal phosphate binding protein)
Type: protein-coding
Summary: This gene encodes a pyridoxal 5'-phosphate binding protein involved in the homeostatic regulation of intracellular pyridoxal 5'-phosphate. This gene has a tumor suppressive effect on hepatocellular carcinoma and other solid ... |
Does Knockout of RPS23 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | RPS23 | response to chemicals | Glioblastoma Cell Line | Gene: RPS23 (ribosomal protein S23)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of DPM3 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | DPM3 | cell proliferation | Ovarian Cancer Cell Line | Gene: DPM3 (dolichyl-phosphate mannosyltransferase subunit 3, regulatory)
Type: protein-coding
Summary: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-an... |
Does Knockout of PWWP2B in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | PWWP2B | cell proliferation | Mammary Gland Tumor Cell Line | Gene: PWWP2B (PWWP domain containing 2B)
Type: protein-coding
Summary: Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin remodeling, positive regulation of transcription elongation by RNA polymerase II, regulation of cold-induced thermogen... |
Does Knockout of NGDN in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | NGDN | cell proliferation | Endometrial Cancer Cell Line | Gene: NGDN (neuroguidin)
Type: protein-coding
Summary: Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMI... |
Does Knockout of PSME3 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | PSME3 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: PSME3 (proteasome activator subunit 3)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are comp... |
Does Knockout of RACK1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | RACK1 | cell proliferation | Glioblastoma Cell Line | Gene: RACK1 (receptor for activated C kinase 1)
Type: protein-coding
Summary: Enables several functions, including cyclin binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulatio... |
Does Knockout of EXOC5 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | EXOC5 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: EXOC5 (exocyst complex component 5)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the c... |
Does Knockout of RPL36 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | RPL36 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: RPL36 (ribosomal protein L36)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
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