prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Activation of CCDC158 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
CCDC158
|
protein/peptide accumulation
|
T cell
|
Gene: CCDC158 (coiled-coil domain containing 158)
Type: protein-coding
Summary: coiled-coil domain containing 158
Gene Ontology: MF: clathrin binding, protein binding; CC: clathrin-coated vesicle, early endosome
Pathways:
UniProt: Q5M9N0
Entrez ID: 339965
|
Does Knockout of EFNB3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
EFNB3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: EFNB3 (ephrin B3)
Type: protein-coding
Summary: EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell costimulation, adult walking behavior, axon choice point recognition, axon guidance, cell differentiation, cell-cell signaling, ephrin receptor signaling pathway, negative regulation of axonogenesis, nervous system development, symbiont entry into host cell, trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission; MF: ephrin receptor binding, protein binding, transmembrane-ephrin receptor activity, virus receptor activity; CC: glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, membrane, plasma membrane, presynaptic membrane
Pathways: Axon guidance, Axon guidance - Homo sapiens (human), Cell migration and invasion through p75NTR, Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHB forward signaling, EPHB-mediated forward signaling, Ephrin signaling, Nervous system development
UniProt: Q15768
Entrez ID: 1949
|
Does Knockout of TPI1 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
TPI1
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: TPI1 (triosephosphate isomerase 1)
Type: protein-coding
Summary: This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009].
Gene Ontology: BP: canonical glycolysis, gluconeogenesis, glucose metabolic process, glyceraldehyde-3-phosphate biosynthetic process, glyceraldehyde-3-phosphate metabolic process, glycerol catabolic process, glycolytic process, methylglyoxal biosynthetic process; MF: isomerase activity, lyase activity, methylglyoxal synthase activity, protein binding, protein homodimerization activity, triose-phosphate isomerase activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, extracellular exosome, extracellular space, nucleus
Pathways: Computational Model of Aerobic Glycolysis, Cori Cycle, Fanconi-bickel syndrome, Fatty acid beta-oxidation, Fructose and Mannose Degradation, Fructose and mannose metabolism - Homo sapiens (human), Fructose intolerance, hereditary, Fructose-1,6-diphosphatase deficiency, Fructosuria, Gluconeogenesis, Glucose metabolism, Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycogenosis, Type VII. Tarui disease, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, HIF1A and PPARG regulation of glycolysis, Inositol phosphate metabolism - Homo sapiens (human), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pathways in clear cell renal cell carcinoma, Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Triosephosphate isomerase, gluconeogenesis, glycolysis, sucrose degradation, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P60174
Entrez ID: 7167
|
Does Knockout of FUT3 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
FUT3
|
response to virus
|
Hepatoma Cell Line
|
Gene: FUT3 (fucosyltransferase 3 (Lewis blood group))
Type: protein-coding
Summary: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Differences in the expression of this gene are associated with host susceptibility to viral infection. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: cell-cell recognition, ceramide metabolic process, fucosylation, lipid metabolic process, macromolecule glycosylation, oligosaccharide biosynthetic process, oligosaccharide metabolic process, positive regulation of cell-cell adhesion, protein N-linked glycosylation, protein O-linked glycosylation, protein glycosylation, regulation of cell migration, regulation of cell population proliferation, sphingolipid metabolic process; MF: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity, 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity, alpha-(1->3)-fucosyltransferase activity, fucosyltransferase activity, glycosyltransferase activity, protein binding, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, extracellular exosome, membrane
Pathways: Asparagine N-linked glycosylation, Blood group systems biosynthesis, Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human), Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, N-glycan antennae elongation in the medial/trans-Golgi, Post-translational protein modification, Reactions specific to the complex N-glycan synthesis pathway, Transport to the Golgi and subsequent modification
UniProt: P21217
Entrez ID: 2525
|
Does Knockout of ALAS1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
ALAS1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ALAS1 (5'-aminolevulinate synthase 1)
Type: protein-coding
Summary: This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015].
Gene Ontology: BP: cellular response to insulin stimulus, erythrocyte development, heme A biosynthetic process, heme B biosynthetic process, heme O biosynthetic process, heme biosynthetic process, hemoglobin biosynthetic process, porphyrin-containing compound metabolic process, protoporphyrinogen IX biosynthetic process, response to bile acid, response to cAMP, response to cobalt ion, response to ethanol, response to gonadotropin, response to herbicide, response to hypoxia, response to nickel cation, response to nutrient levels, response to platinum ion, response to xenobiotic stimulus, tetrapyrrole biosynthetic process; MF: 5-aminolevulinate synthase activity, acyltransferase activity, identical protein binding, protein binding, pyridoxal phosphate binding, transferase activity; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, nucleoplasm
Pathways: 3-Phosphoglycerate dehydrogenase deficiency, Acute Intermittent Porphyria, Congenital Erythropoietic Porphyria (CEP) or Gunther Disease, Constitutive Androstane Receptor Pathway, Dihydropyrimidine Dehydrogenase Deficiency (DHPD), Dimethylglycine Dehydrogenase Deficiency, FOXA2 and FOXA3 transcription factor networks, Glycine and Serine Metabolism, Glycine, serine and threonine metabolism - Homo sapiens (human), Heme Biosynthesis, Heme biosynthesis, Hereditary Coproporphyria (HCP), Hyperglycinemia, non-ketotic, Metabolism, Metabolism of lipids, Metabolism of porphyrins, Metabolism of proteins, Mitochondrial biogenesis, Mitochondrial protein degradation, Non Ketotic Hyperglycinemia, Nuclear Receptors Meta-Pathway, Organelle biogenesis and maintenance, PPARA activates gene expression, Porphyria Variegata (PV), Porphyrin Metabolism, Porphyrin and chlorophyll metabolism - Homo sapiens (human), Regulation of lipid metabolism by PPARalpha, Sarcosinemia, Transcriptional activation of mitochondrial biogenesis, heme biosynthesis, hemoglobins chaperone, tetrapyrrole biosynthesis
UniProt: P13196
Entrez ID: 211
|
Does Knockout of QPCTL in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
QPCTL
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: QPCTL (glutaminyl-peptide cyclotransferase like)
Type: protein-coding
Summary: Enables glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Acts upstream of or within peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase; MF: acyltransferase activity, glutaminyl-peptide cyclotransferase activity, metal ion binding, protein binding, transferase activity, zinc ion binding; CC: Golgi apparatus, Golgi membrane, membrane
Pathways:
UniProt: Q9NXS2
Entrez ID: 54814
|
Does Knockout of DTL in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
DTL
|
cell proliferation
|
Melanoma Cell Line
|
Gene: DTL (denticleless E3 ubiquitin protein ligase adapter)
Type: protein-coding
Summary: Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in centrosome; cytosol; and nuclear lumen. Part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA replication, mitotic G2 DNA damage checkpoint signaling, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of catabolic process, positive regulation of protein catabolic process, positive regulation of protein metabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of cell cycle, response to UV, rhythmic process, translesion synthesis, ubiquitin-dependent protein catabolic process; MF: protein binding, protein-macromolecule adaptor activity, ubiquitin-protein transferase activity; CC: Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, centrosome, chromosome, cytoplasm, cytoskeleton, cytosol, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Repair, Metabolism of proteins, Neddylation, Post-translational protein modification, Recognition of DNA damage by PCNA-containing replication complex
UniProt: Q9NZJ0
Entrez ID: 51514
|
Does Knockout of RBBP8 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
RBBP8
|
response to virus
|
Hepatoma Cell Line
|
Gene: RBBP8 (RB binding protein 8, endonuclease)
Type: protein-coding
Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA double-strand break processing involved in repair via single-strand annealing, DNA repair, DNA strand resection involved in replication fork processing, G1/S transition of mitotic cell cycle, blastocyst hatching, cell division, double-strand break repair via homologous recombination, homologous recombination, meiotic cell cycle, mitotic G2/M transition checkpoint, negative regulation of DNA-templated transcription; MF: DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, damaged DNA binding, endonuclease activity, hydrolase activity, identical protein binding, metal ion binding, nuclease activity, protein binding, single-stranded DNA endodeoxyribonuclease activity, transcription corepressor activity; CC: BRCA1-C complex, chromosome, nucleoplasm, nucleus, site of double-strand break, transcription repressor complex
Pathways: ATM Signaling Network in Development and Disease, ATM pathway, BARD1 signaling events, E2F transcription factor network, Homologous recombination - Homo sapiens (human), Notch signaling pathway, Notch-mediated HES/HEY network, atm signaling pathway
UniProt: Q99708
Entrez ID: 5932
|
Does Knockout of BUD13 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
BUD13
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: BUD13 (BUD13 spliceosome associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: RES complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9BRD0
Entrez ID: 84811
|
Does Knockout of ZNF687 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
ZNF687
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ZNF687 (zinc finger protein 687)
Type: protein-coding
Summary: This gene encodes C2H2 zinc finger protein. The encoded protein may play a role in bone differentiation and development. Mutations in this gene are the cause of Paget disease of bone-6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8N1G0
Entrez ID: 57592
|
Does Knockout of TSR2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
TSR2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TSR2 (TSR2 ribosome maturation factor)
Type: protein-coding
Summary: The protein encoded by this gene appears to repress the transcription of NF-kappaB and may be involved in apoptosis. Defects in this gene are a cause of Diamond-Blackfan anemia. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing
Pathways:
UniProt: Q969E8
Entrez ID: 90121
|
Does Knockout of GOSR2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
GOSR2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: GOSR2 (golgi SNAP receptor complex member 2)
Type: protein-coding
Summary: This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, protein transport, vesicle fusion, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding, protein binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, SNARE complex, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, late endosome membrane, membrane, nucleoplasm
Pathways: Arf1 pathway, Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, Cargo concentration in the ER, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, IRE1alpha activates chaperones, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Homo sapiens (human), Transport to the Golgi and subsequent modification, Unfolded Protein Response (UPR), Vesicle-mediated transport, XBP1(S) activates chaperone genes
UniProt: O14653
Entrez ID: 9570
|
Does Knockout of CDCA8 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
CDCA8
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CDCA8 (cell division cycle associated 8)
Type: protein-coding
Summary: This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: cell division, chromosome organization, mitotic cell cycle, mitotic cytokinesis, mitotic metaphase chromosome alignment, mitotic sister chromatid segregation, mitotic spindle assembly, mitotic spindle midzone assembly, positive regulation of attachment of mitotic spindle microtubules to kinetochore, positive regulation of mitotic cell cycle spindle assembly checkpoint, positive regulation of mitotic cytokinesis, positive regulation of mitotic sister chromatid separation; CC: chromocenter, chromosome, chromosome passenger complex, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, intercellular bridge, microtubule cytoskeleton, midbody, nucleolus, nucleoplasm, nucleus, protein-containing complex, spindle, spindle midzone
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Aurora B signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q53HL2
Entrez ID: 55143
|
Does Knockout of THOC3 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
THOC3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: THOC3 (THO complex subunit 3)
Type: protein-coding
Summary: This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013].
Gene Ontology: BP: RNA splicing, mRNA export from nucleus, mRNA processing, mRNA transport; CC: THO complex part of transcription export complex, chromosome, telomeric region, nuclear speck, nucleoplasm, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, RNA transport - Homo sapiens (human), Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q96J01
Entrez ID: 84321
|
Does Knockout of SDC1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
SDC1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: SDC1 (syndecan 1)
Type: protein-coding
Summary: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: canonical Wnt signaling pathway, cell migration, myoblast development, positive regulation of exosomal secretion, positive regulation of extracellular exosome assembly, receptor-mediated endocytosis, striated muscle cell development; MF: cargo receptor activity, identical protein binding, protein binding; CC: Golgi lumen, cell surface, external side of plasma membrane, extracellular exosome, extracellular region, lysosomal lumen, membrane, plasma membrane
Pathways: Attachment and Entry, Beta3 integrin cell surface interactions, Beta5 beta6 beta7 and beta8 integrin cell surface interactions, Cell adhesion molecules - Homo sapiens (human), Cell surface interactions at the vascular wall, Cytokine Signaling in Immune system, Defective B3GALT6 causes EDSP2 and SEMDJL1, Defective B3GAT3 causes JDSSDHD, Defective B4GALT7 causes EDS, progeroid type, Defective EXT1 causes exostoses 1, TRPS2 and CHDS, Defective EXT2 causes exostoses 2, Disease, Diseases associated with glycosaminoglycan metabolism, Diseases of glycosylation, Diseases of metabolism, ECM-receptor interaction - Homo sapiens (human), EGFR1, Early SARS-CoV-2 Infection Events, Extracellular matrix organization, Fibroblast growth factor-1, Fluid shear stress and atherosclerosis - Homo sapiens (human), Glycosaminoglycan metabolism, Glycosaminoglycan-protein linkage region biosynthesis, HS-GAG biosynthesis, HS-GAG degradation, Hemostasis, Heparan sulfate/heparin (HS-GAG) metabolism, Immune System, Infectious disease, Integrins in angiogenesis, Malaria - Homo sapiens (human), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Non-integrin membrane-ECM interactions, Other interleukin signaling, Proteoglycan syndecan-mediated signaling events, Proteoglycans in cancer - Homo sapiens (human), RSV-host interactions, Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) attachment and entry, Retinoid metabolism and transport, SARS-CoV Infections, SARS-CoV-2 Infection, Sensory Perception, Signaling by Interleukins, Syndecan interactions, Syndecan-1-mediated signaling events, Viral Infection Pathways, Visual phototransduction
UniProt: P18827
Entrez ID: 6382
|
Does Knockout of C20orf96 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
C20orf96
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: C20orf96 (chromosome 20 open reading frame 96)
Type: protein-coding
Summary: chromosome 20 open reading frame 96
Gene Ontology:
Pathways:
UniProt: Q9NUD7
Entrez ID: 140680
|
Does Knockout of PSAT1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
PSAT1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PSAT1 (phosphoserine aminotransferase 1)
Type: protein-coding
Summary: This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, and 8. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: L-serine biosynthetic process, L-serine metabolic process, amino acid biosynthetic process, pyridoxine biosynthetic process; MF: O-phospho-L-serine:2-oxoglutarate aminotransferase activity, identical protein binding, protein binding, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: cytoplasm, cytosol, extracellular exosome
Pathways: 3-Phosphoglycerate dehydrogenase deficiency, Cysteine and methionine metabolism - Homo sapiens (human), Dihydropyrimidine Dehydrogenase Deficiency (DHPD), Dimethylglycine Dehydrogenase Deficiency, Glycine and Serine Metabolism, Glycine, serine and threonine metabolism - Homo sapiens (human), Hyperglycinemia, non-ketotic, Male infertility, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of amino acids and derivatives, Non Ketotic Hyperglycinemia, Pathways in clear cell renal cell carcinoma, Sarcosinemia, Serine metabolism, Trans-sulfuration and one-carbon metabolism, Vitamin B6 metabolism - Homo sapiens (human), serine and glycine biosynthesis, serine biosynthesis (phosphorylated route)
UniProt: Q9Y617
Entrez ID: 29968
|
Does Knockout of TRPV3 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
TRPV3
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: TRPV3 (transient receptor potential cation channel subfamily V member 3)
Type: protein-coding
Summary: This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: actin filament organization, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of hair cycle, osmosensory signaling pathway, positive regulation of calcium ion import, response to temperature stimulus, sodium ion transmembrane transport, transmembrane transport; MF: calcium channel activity, identical protein binding, metal ion binding, monoatomic cation channel activity, monoatomic ion channel activity, protein binding, sodium channel activity; CC: cilium, cytoplasm, lysosome, membrane, plasma membrane, receptor complex
Pathways: Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Ion channel transport, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q8NET8
Entrez ID: 162514
|
Does Knockout of C4orf17 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
C4orf17
|
response to virus
|
Lung Cancer Cell Line
|
Gene: C4orf17 (chromosome 4 open reading frame 17)
Type: protein-coding
Summary: chromosome 4 open reading frame 17
Gene Ontology:
Pathways:
UniProt: Q53FE4
Entrez ID: 84103
|
Does Knockout of AQR in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
AQR
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: AQR (aquarius intron-binding spliceosomal factor)
Type: protein-coding
Summary: Enables 3'-5' RNA helicase activity and single-stranded RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: 3'-5' RNA helicase activity, ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, mRNA binding, nucleotide binding, protein binding, single-stranded RNA binding; CC: U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, membrane, nucleoplasm, nucleus, spliceosomal complex
Pathways: DNA Repair, Dual incision in TC-NER, Formation of TC-NER Pre-Incision Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Metabolism of RNA, Nucleotide Excision Repair, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), Transcription-Coupled Nucleotide Excision Repair (TC-NER), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O60306
Entrez ID: 9716
|
Does Knockout of TMTC1 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
TMTC1
|
response to virus
|
Lung Cancer Cell Line
|
Gene: TMTC1 (transmembrane O-mannosyltransferase targeting cadherins 1)
Type: protein-coding
Summary: Enables mannosyltransferase activity. Involved in protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA processing, protein O-linked glycosylation via mannose, protein glycosylation; MF: dolichyl-phosphate-mannose-protein mannosyltransferase activity, mannosyltransferase activity, protein binding, transferase activity; CC: endoplasmic reticulum, membrane
Pathways:
UniProt: Q8IUR5
Entrez ID: 83857
|
Does Knockout of ELP1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
ELP1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: ELP1 (elongator acetyltransferase complex subunit 1)
Type: protein-coding
Summary: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: regulation of translation, tRNA processing, tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation, tRNA wobble uridine modification; MF: protein binding, tRNA binding; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, IL1, TNFalpha
UniProt: O95163
Entrez ID: 8518
|
Does Knockout of CHD4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
CHD4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CHD4 (chromodomain helicase DNA binding protein 4)
Type: protein-coding
Summary: The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: chromatin organization, chromatin remodeling, double-strand break repair via homologous recombination, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, oxygen transport, positive regulation of DNA-templated transcription, regulation of cell fate specification, regulation of stem cell differentiation, regulation of synapse assembly, terminal button organization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent chromatin remodeler activity, DNA binding, DNA-binding transcription factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, histone binding, histone deacetylase binding, hydrolase activity, metal ion binding, nucleosomal DNA binding, nucleotide binding, protein binding, transcription coregulator binding, transcription corepressor activity, zinc ion binding; CC: NuRD complex, RNA polymerase II transcription regulator complex, centrosome, cerebellar granule cell to Purkinje cell synapse, chromatin, chromosome, telomeric region, cytoplasm, cytoskeleton, membrane, nucleoplasm, nucleus, protein-containing complex, site of DNA damage
Pathways: Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome, Human papillomavirus infection - Homo sapiens (human), Rett syndrome causing genes, Signaling events mediated by HDAC Class I, Viral carcinogenesis - Homo sapiens (human)
UniProt: Q14839
Entrez ID: 1108
|
Does Knockout of ASH2L in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
ASH2L
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: ASH2L (ASH2 like, histone lysine methyltransferase complex subunit)
Type: protein-coding
Summary: Enables beta-catenin binding activity and transcription cis-regulatory region binding activity. Contributes to histone methyltransferase activity (H3-K4 specific). Involved in histone H3-K4 methylation; positive regulation of cell population proliferation; and response to estrogen. Acts upstream of or within cellular response to DNA damage stimulus. Located in nucleus. Part of MLL3/4 complex and Set1C/COMPASS complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, chromatin organization, hemopoiesis, positive regulation of cell population proliferation, positive regulation of macromolecule biosynthetic process, regulation of gene expression, response to estrogen, transcription initiation-coupled chromatin remodeling; MF: DNA binding, beta-catenin binding, metal ion binding, protein binding, transcription cis-regulatory region binding, zinc ion binding; CC: MLL1 complex, MLL1/2 complex, MLL3/4 complex, Set1C/COMPASS complex, histone methyltransferase complex, nucleoplasm, nucleus
Pathways: Cushing syndrome - Homo sapiens (human)
UniProt: Q9UBL3
Entrez ID: 9070
|
Does Knockout of PROX1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
PROX1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: PROX1 (prospero homeobox 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: acinar cell differentiation, anatomical structure formation involved in morphogenesis, aorta smooth muscle tissue morphogenesis, atrial cardiac muscle tissue morphogenesis, blood vessel endothelial cell differentiation, brain development, branching involved in pancreas morphogenesis, cell fate commitment, cell population proliferation, central nervous system development, cerebellar granule cell differentiation, circadian rhythm, dentate gyrus development, dorsal spinal cord development, embryonic retina morphogenesis in camera-type eye, endocardium formation, epithelial cell migration, hepatocyte cell migration, hepatocyte differentiation, hepatocyte proliferation, inner ear development, kidney development, lens development in camera-type eye, lens fiber cell morphogenesis, lens morphogenesis in camera-type eye, lens placode formation involved in camera-type eye formation, liver development, lung development, lymph vessel development, lymphangiogenesis, lymphatic endothelial cell differentiation, lymphatic endothelial cell fate commitment, negative regulation of DNA-templated transcription, negative regulation of bile acid biosynthetic process, negative regulation of cell population proliferation, negative regulation of neuroblast proliferation, negative regulation of transcription by RNA polymerase II, negative regulation of viral genome replication, neural tube development, neuroblast proliferation, neuron fate determination, neuronal stem cell population maintenance, olfactory placode formation, otic placode formation, pancreas development, positive regulation of cell cycle, positive regulation of cell cycle checkpoint, positive regulation of cell population proliferation, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of forebrain neuron differentiation, positive regulation of heart growth, positive regulation of neural precursor cell proliferation, positive regulation of sarcomere organization, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial growth factor signaling pathway, regulation of DNA-templated transcription, regulation of circadian rhythm, regulation of gene expression, regulation of transcription by RNA polymerase II, response to nutrient levels, retina morphogenesis in camera-type eye, rhythmic process, skeletal muscle thin filament assembly, transcription by RNA polymerase II, tube development, venous blood vessel morphogenesis, ventricular cardiac muscle tissue morphogenesis, ventricular cardiac myofibril assembly, ventricular septum morphogenesis; MF: DNA binding, DNA binding domain binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, LBD domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, nuclear receptor binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Epithelial to mesenchymal transition in colorectal cancer, PTF1A related regulatory pathway
UniProt: Q92786
Entrez ID: 5629
|
Does Knockout of CEMIP in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
CEMIP
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CEMIP (cell migration inducing hyaluronidase 1)
Type: protein-coding
Summary: Enables several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of protein phosphorylation; and positive regulation of transport. Located in clathrin-coated endocytic vesicle; endoplasmic reticulum; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: hyaluronan biosynthetic process, hyaluronan catabolic process, hyaluronan metabolic process, positive regulation of cell migration, positive regulation of peptidyl-threonine phosphorylation, positive regulation of protein kinase C activity, positive regulation of protein targeting to membrane, positive regulation of release of sequestered calcium ion into cytosol, sensory perception of sound; MF: ER retention sequence binding, carbohydrate binding, clathrin heavy chain binding, hyaluronic acid binding, hyalurononglucosaminidase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, protein binding; CC: clathrin-coated endocytic vesicle, clathrin-coated pit, clathrin-coated vesicle membrane, cytoplasm, endoplasmic reticulum, extracellular region, fibrillar center, membrane, nuclear membrane, nucleus, plasma membrane
Pathways: Glycosaminoglycan metabolism, Hyaluronan degradation, Hyaluronan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q8WUJ3
Entrez ID: 57214
|
Does Knockout of NLE1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
NLE1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: NLE1 (notchless homolog 1)
Type: protein-coding
Summary: Predicted to be involved in Notch signaling pathway and ribosomal large subunit assembly. Predicted to act upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and regulation of signal transduction. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Notch signaling pathway, hematopoietic stem cell homeostasis, inner cell mass cell differentiation, kidney development, mitotic cell cycle, negative regulation of mitotic cell cycle, positive regulation of canonical Wnt signaling pathway, regulation of Notch signaling pathway, ribosomal large subunit biogenesis, skeletal system morphogenesis, somitogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9NVX2
Entrez ID: 54475
|
Does Knockout of ATP6V0D1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
ATP6V0D1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ATP6V0D1 (ATPase H+ transporting V0 subunit d1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell projection organization, cellular response to increased oxygen levels, cilium assembly, homeostatic process, intracellular iron ion homeostasis, monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification, vacuolar acidification, vacuolar transport; MF: protein binding, protein-containing complex binding, proton-transporting ATPase activity, rotational mechanism; CC: apical plasma membrane, axon terminus, centrosome, clathrin-coated vesicle membrane, cytoplasmic vesicle, early endosome, endosome membrane, extracellular exosome, lysosomal membrane, lysosome, membrane, phagocytic vesicle membrane, plasma membrane proton-transporting V-type ATPase complex, protein-containing complex, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V0 domain, synaptic vesicle, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IRE1alpha activates chaperones, Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Homo sapiens (human), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Homo sapiens (human), Unfolded Protein Response (UPR), VEGFA-VEGFR2 Signaling Pathway, Vibrio cholerae infection - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), XBP1(S) activates chaperone genes, adenosine ribonucleotides <i>de novo</i> biosynthesis, purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: P61421
Entrez ID: 9114
|
Does Activation of ADAMTS16 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
ADAMTS16
|
protein/peptide accumulation
|
T cell
|
Gene: ADAMTS16 (ADAM metallopeptidase with thrombospondin type 1 motif 16)
Type: protein-coding
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016].
Gene Ontology: BP: branching involved in ureteric bud morphogenesis, extracellular matrix organization, male gamete generation, proteolysis, regulation of cilium assembly, regulation of systemic arterial blood pressure; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity; CC: extracellular matrix, extracellular region
Pathways: Defective B3GALTL causes PpS, Degradation of the extracellular matrix, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Extracellular matrix organization, Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8TE57
Entrez ID: 170690
|
Does Knockout of SDF2L1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
SDF2L1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: SDF2L1 (stromal cell derived factor 2 like 1)
Type: protein-coding
Summary: Enables misfolded protein binding activity. Involved in chaperone cofactor-dependent protein refolding. Located in endoplasmic reticulum. Part of chaperone complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERAD pathway, cellular response to misfolded protein, protein refolding, regulation of apoptotic process, response to endoplasmic reticulum stress; MF: ATPase binding, misfolded protein binding, protein binding, protein-folding chaperone binding; CC: endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, membrane, protein folding chaperone complex
Pathways: Acetaminophen Metabolism Pathway, Etoposide Action Pathway, Etoposide Metabolism Pathway, Ibuprofen Action Pathway, Ibuprofen Metabolism Pathway, Irinotecan Action Pathway, Irinotecan Metabolism Pathway, Morphine Action Pathway, Morphine Metabolism Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Retinol Metabolism, Sorafenib Metabolism Pathway, VEGFA-VEGFR2 Signaling Pathway, Vitamin A Deficiency
UniProt: Q9HCN8
Entrez ID: 23753
|
Does Knockout of KRT17 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
KRT17
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: KRT17 (keratin 17)
Type: protein-coding
Summary: This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: epithelial cell differentiation, hair follicle morphogenesis, intermediate filament organization, keratinization, morphogenesis of an epithelium, positive regulation of cell growth, positive regulation of hair follicle development, positive regulation of translation; MF: protein binding, structural constituent of skin epidermis, structural molecule activity; CC: cell periphery, cornified envelope, cytoplasm, cytoskeleton, cytosol, intermediate filament, intermediate filament cytoskeleton, keratin filament
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Pancreatic Ductal Cells, EGFR1, Estrogen signaling pathway - Homo sapiens (human), Formation of the cornified envelope, Glucocorticoid receptor regulatory network, Keratinization, Staphylococcus aureus infection - Homo sapiens (human)
UniProt: Q04695
Entrez ID: 3872
|
Does Knockout of RBM4B in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
RBM4B
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: RBM4B (RNA binding motif protein 4B)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in entrainment of circadian clock by photoperiod; mRNA splicing, via spliceosome; and regulation of gene expression. Predicted to act upstream of or within positive regulation of gene expression. Located in cytosol and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, circadian regulation of gene expression, circadian rhythm, entrainment of circadian clock by photoperiod, mRNA processing, positive regulation of gene expression, regulation of alternative mRNA splicing, via spliceosome, regulation of translation; MF: RNA binding, mRNA binding, metal ion binding, nucleic acid binding, protein binding, zinc ion binding; CC: cytosol, nuclear speck, nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q9BQ04
Entrez ID: 83759
|
Does Knockout of TMEM220 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
TMEM220
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: TMEM220 (transmembrane protein 220)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q6QAJ8
Entrez ID: 388335
|
Does Activation of CCNB1IP1 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
CCNB1IP1
|
protein/peptide accumulation
|
T cell
|
Gene: CCNB1IP1 (cyclin B1 interacting protein 1)
Type: protein-coding
Summary: HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: blastocyst formation, chiasma assembly, meiotic cell cycle, protein ubiquitination, reciprocal meiotic recombination, spermatid development; MF: identical protein binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: chromosome, condensed nuclear chromosome, nucleus, synaptonemal complex
Pathways:
UniProt: Q9NPC3
Entrez ID: 57820
|
Does Knockout of OLFML1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
OLFML1
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: OLFML1 (olfactomedin like 1)
Type: protein-coding
Summary: Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular region, extracellular space
Pathways:
UniProt: Q6UWY5
Entrez ID: 283298
|
Does Knockout of NUS1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
NUS1
|
cell proliferation
|
Cancer Cell Line
|
Gene: NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit)
Type: protein-coding
Summary: This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017].
Gene Ontology: BP: angiogenesis, cell differentiation, cholesterol homeostasis, dolichyl diphosphate biosynthetic process, dolichyl monophosphate biosynthetic process, lipid metabolic process, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, positive regulation of cell migration involved in sprouting angiogenesis, protein glycosylation, regulation of intracellular cholesterol transport, sterol homeostasis, vascular endothelial growth factor signaling pathway; MF: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity, metal ion binding, prenyltransferase activity, protein binding, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: dehydrodolichyl diphosphate synthase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective DHDDS causes RP59, Disease, Diseases associated with glycosylation precursor biosynthesis, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, Post-translational protein modification, Synthesis of dolichyl-phosphate, Synthesis of substrates in N-glycan biosythesis, Terpenoid backbone biosynthesis - Homo sapiens (human)
UniProt: Q96E22
Entrez ID: 116150
|
Does Knockout of HSPE1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
HSPE1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: HSPE1 (heat shock protein family E (Hsp10) member 1)
Type: protein-coding
Summary: This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011].
Gene Ontology: BP: intrinsic apoptotic signaling pathway, osteoblast differentiation, protein folding, response to unfolded protein; MF: ATP binding, RNA binding, metal ion binding, protein binding, protein folding chaperone, protein-folding chaperone binding, unfolded protein binding; CC: extracellular exosome, membrane, mitochondrial matrix, mitochondrion
Pathways: Cellular responses to stimuli, Cellular responses to stress, EGFR1, Mitochondrial unfolded protein response (UPRmt), RHO GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P61604
Entrez ID: 3336
|
Does Knockout of CDC42SE1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
CDC42SE1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: CDC42SE1 (CDC42 small effector 1)
Type: protein-coding
Summary: Predicted to enable GTPase inhibitor activity. Predicted to be involved in signal transduction. Located in cell junction. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: phagocytosis, regulation of Rho protein signal transduction, regulation of cell shape, signal transduction; MF: GTPase inhibitor activity, protein binding, small GTPase binding; CC: cell junction, cytoplasm, cytoskeleton, membrane, plasma membrane
Pathways:
UniProt: Q9NRR8
Entrez ID: 56882
|
Does Knockout of MFAP1 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
MFAP1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: MFAP1 (microfibril associated protein 1)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in centrosome; microfibril; and nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: U2-type precatalytic spliceosome, U2-type spliceosomal complex, centrosome, microfibril, nucleoplasm, nucleus, spliceosomal complex
Pathways: Canonical and non-canonical Notch signaling, Ciliary landscape, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P55081
Entrez ID: 4236
|
Does Knockout of NCAPH in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
NCAPH
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: NCAPH (non-SMC condensin I complex subunit H)
Type: protein-coding
Summary: This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: cell division, chromosome condensation, female meiosis chromosome separation, female meiotic nuclear division, meiotic chromosome condensation, meiotic chromosome segregation, mitotic chromosome condensation, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation; MF: chromatin binding, protein binding; CC: chromosome, condensed nuclear chromosome, condensin complex, cytoplasm, cytosol, membrane, nucleoplasm, nucleus
Pathways: Aurora B signaling, Cell Cycle, Cell Cycle, Mitotic, Condensation of Prometaphase Chromosomes, M Phase, Mitotic Prometaphase
UniProt: Q15003
Entrez ID: 23397
|
Does Knockout of FRRS1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
FRRS1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: FRRS1 (ferric chelate reductase 1)
Type: protein-coding
Summary: Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: intracellular iron ion homeostasis; MF: metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on metal ions; CC: membrane
Pathways:
UniProt: Q6ZNA5
Entrez ID: 391059
|
Does Knockout of OR5H14 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
OR5H14
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: OR5H14 (olfactory receptor family 5 subfamily H member 14)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: A6NHG9
Entrez ID: 403273
|
Does Knockout of NMT1 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
NMT1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: NMT1 (N-myristoyltransferase 1)
Type: protein-coding
Summary: Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008].
Gene Ontology: BP: N-terminal peptidyl-glycine N-myristoylation, cellular response to nutrient levels, in utero embryonic development, ketone metabolic process, positive regulation of TORC1 signaling, positive regulation of establishment of protein localization to mitochondrion, positive regulation of protein localization to lysosome, protein localization to membrane, regulation of opsin-mediated signaling pathway; MF: acyltransferase activity, glycylpeptide N-tetradecanoyltransferase activity, myristoyltransferase activity, peptidyl-lysine N6-myristoyltransferase activity, protein binding, transferase activity; CC: cytoplasm, cytosol, membrane, plasma membrane
Pathways:
UniProt: P30419
Entrez ID: 4836
|
Does Knockout of CXCL1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
CXCL1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: CXCL1 (C-X-C motif chemokine ligand 1)
Type: protein-coding
Summary: This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, actin cytoskeleton organization, antimicrobial humoral immune response mediated by antimicrobial peptide, cell chemotaxis, chemotaxis, defense response, immune response, inflammatory response, intracellular signal transduction, killing of cells of another organism, negative regulation of cell population proliferation, nervous system development, signal transduction; MF: chemokine activity, cytokine activity, enzyme activator activity, growth factor activity, protein binding, signaling receptor binding; CC: extracellular region, extracellular space, specific granule lumen, tertiary granule lumen
Pathways: Amoebiasis - Homo sapiens (human), Chemokine receptors bind chemokines, Chemokine signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Cytokines and Inflammatory Response, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, IL-17 signaling pathway - Homo sapiens (human), IL23-mediated signaling events, Immune System, Innate Immune System, Interleukin-10 signaling, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Legionellosis - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), NF-kappa B signaling pathway - Homo sapiens (human), NOD-like receptor signaling pathway - Homo sapiens (human), Neutrophil degranulation, Peptide ligand-binding receptors, Rheumatoid arthritis - Homo sapiens (human), SARS-CoV-2 innate immunity evasion and cell-specific immune response, Senescence and Autophagy in Cancer, Signal Transduction, Signaling by GPCR, Signaling by Interleukins, Spinal Cord Injury, TNF signaling pathway - Homo sapiens (human), Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: P09341
Entrez ID: 2919
|
Does Knockout of OR4K2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
OR4K2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: OR4K2 (olfactory receptor family 4 subfamily K member 2)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGD2
Entrez ID: 390431
|
Does Activation of ARHGAP12 in T cell causally result in protein/peptide accumulation?
| 1
| 2,425
|
Activation
|
ARHGAP12
|
protein/peptide accumulation
|
T cell
|
Gene: ARHGAP12 (Rho GTPase activating protein 12)
Type: protein-coding
Summary: This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: actin filament organization, morphogenesis of an epithelial sheet, negative regulation of small GTPase mediated signal transduction, phagocytosis, engulfment, regulation of postsynapse assembly, signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity, protein binding; CC: cytoplasm, glutamatergic synapse, phagocytic cup, plasma membrane, postsynapse
Pathways:
UniProt: Q8IWW6
Entrez ID: 94134
|
Does Knockout of MRPL12 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
MRPL12
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MRPL12 (mitochondrial ribosomal protein L12)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial transcription, mitochondrial translation, positive regulation of DNA-templated transcription, translation; MF: RNA binding, mRNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial matrix, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: P52815
Entrez ID: 6182
|
Does Knockout of FPGT-TNNI3K in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
FPGT-TNNI3K
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: FPGT-TNNI3K (FPGT-TNNI3K readthrough)
Type: protein-coding
Summary: This locus represents naturally occurring read-through transcription from the neighboring fucose-1-phosphate guanylyltransferase (FPGT) and TNNI3 interacting kinase (TNNI3K) genes. Alternative splicing results in multiple transcript variants that are composed of in-frame exons from each individual gene. [provided by RefSeq, Dec 2010]
Gene Ontology:
Pathways:
UniProt: Q59H18
Entrez ID: 100526835
|
Does Knockout of CDC26 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
CDC26
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CDC26 (cell division cycle 26)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; CC: anaphase-promoting complex, cytosol, nucleoplasm, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q8NHZ8
Entrez ID: 246184
|
Does Knockout of KANSL1L in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
KANSL1L
|
cell proliferation
|
Bladder Carcinoma
|
Gene: KANSL1L (KAT8 regulatory NSL complex subunit 1 like)
Type: protein-coding
Summary: Predicted to enable histone acetyltransferase binding activity. Predicted to be part of NSL complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: H4 histone acetyltransferase complex, NSL complex, histone acetyltransferase complex
Pathways:
UniProt: A0AUZ9
Entrez ID: 151050
|
Does Knockout of PRPF6 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
PRPF6
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PRPF6 (pre-mRNA processing factor 6)
Type: protein-coding
Summary: The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA localization, RNA processing, RNA splicing, RNA splicing, via transesterification reactions, mRNA processing, mRNA splicing, via spliceosome, positive regulation of transcription by RNA polymerase II, spliceosomal complex assembly, spliceosomal tri-snRNP complex assembly; MF: RNA binding, identical protein binding, protein binding, protein-macromolecule adaptor activity, ribonucleoprotein complex binding; CC: U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, centrosome, ciliary basal body, cytosol, membrane, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: O94906
Entrez ID: 24148
|
Does Knockout of CD63 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
CD63
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: CD63 (CD63 molecule)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: cell differentiation, cell migration, cell-matrix adhesion, endosome to melanosome transport, epithelial cell differentiation, negative regulation of epithelial cell migration, pigment cell differentiation, pigment granule maturation, pigmentation, positive regulation of cell adhesion, positive regulation of endocytosis, positive regulation of integrin-mediated signaling pathway, positive regulation of receptor internalization, protein transport, regulation of potassium ion transmembrane transport, regulation of vascular endothelial growth factor signaling pathway; MF: protein binding, protein-containing complex binding; CC: azurophil granule membrane, cell surface, endosome, endosome lumen, endosome membrane, extracellular exosome, extracellular region, extracellular space, late endosome, late endosome membrane, lysosomal membrane, lysosome, melanosome, membrane, multivesicular body, multivesicular body membrane, multivesicular body, internal vesicle, nucleoplasm, plasma membrane, platelet dense granule membrane, protein-containing complex, vesicle
Pathways: Extracellular vesicles in the crosstalk of cardiac cells, Hemostasis, Immune System, Innate Immune System, Lysosome - Homo sapiens (human), Neutrophil degranulation, Platelet activation, signaling and aggregation, Platelet degranulation , Proteoglycans in cancer - Homo sapiens (human), Response to elevated platelet cytosolic Ca2+
UniProt: P08962
Entrez ID: 967
|
Does Knockout of NUP205 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
NUP205
|
cell proliferation
|
Cancer Cell Line
|
Gene: NUP205 (nucleoporin 205)
Type: protein-coding
Summary: This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with steroid-resistant nephrotic syndrome. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: mRNA transport, nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport, protein transport; MF: protein binding, structural constituent of nuclear pore; CC: cytosol, membrane, nuclear envelope, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q92621
Entrez ID: 23165
|
Does Knockout of GNAS in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
GNAS
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GNAS (GNAS complex locus)
Type: protein-coding
Summary: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, activation of adenylate cyclase activity, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-activating dopamine receptor signaling pathway, adenylate cyclase-activating serotonin receptor signaling pathway, bone development, cellular response to acidic pH, cellular response to catecholamine stimulus, cellular response to glucagon stimulus, cellular response to prostaglandin E stimulus, cognition, developmental growth, female pregnancy, hair follicle placode formation, intracellular transport, negative regulation of inflammatory response to antigenic stimulus, negative regulation of multicellular organism growth, platelet aggregation, positive regulation of cold-induced thermogenesis, positive regulation of phagocytosis, protein secretion, regulation of insulin secretion, regulation of signal transduction, regulation of skeletal muscle contraction, renal water homeostasis, response to parathyroid hormone, response to prostaglandin E, sensory perception of chemical stimulus, sensory perception of smell, signal transduction, vascular endothelial cell response to laminar fluid shear stress; MF: D1 dopamine receptor binding, G protein activity, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, adenylate cyclase activator activity, adenylate cyclase regulator activity, beta-2 adrenergic receptor binding, corticotropin-releasing hormone receptor 1 binding, guanyl nucleotide binding, hydrolase activity, insulin-like growth factor receptor binding, ionotropic glutamate receptor binding, metal ion binding, mu-type opioid receptor binding, nucleotide binding, protein binding; CC: apical plasma membrane, cell projection, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, extracellular region, heterotrimeric G-protein complex, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, ruffle, trans-Golgi network membrane, transport vesicle
Pathways: -arrestins in gpcr desensitization, ADORA2B mediated anti-inflammatory cytokines production, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alcoholism - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Amoebiasis - Homo sapiens (human), Amphetamine addiction - Homo sapiens (human), Anti-inflammatory response favouring Leishmania parasite infection, Aquaporin-mediated transport, Bile secretion - Homo sapiens (human), CRH, Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chagas disease - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Class B/2 (Secretin family receptors), Cocaine addiction - Homo sapiens (human), Common Pathways Underlying Drug Addiction, Corticotropin Activation of Cortisol Production, Corticotropin-releasing hormone signaling pathway, Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Dilated cardiomyopathy - Homo sapiens (human), Disease, Dopamine Activation of Neurological Reward System, Dopaminergic synapse - Homo sapiens (human), Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), Endothelin Pathways, Endothelins, Estrogen signaling pathway, Estrogen signaling pathway - Homo sapiens (human), Excitatory Neural Signalling Through 5-HTR 4 and Serotonin, Excitatory Neural Signalling Through 5-HTR 6 and Serotonin , Excitatory Neural Signalling Through 5-HTR 7 and Serotonin , G Protein Signaling Pathways, G alpha (i) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, GPCR downstream signalling, GPCR ligand binding, GPER1 signaling, Gap junction - Homo sapiens (human), Gastric acid secretion - Homo sapiens (human), Glucagon signaling in metabolic regulation, Glucagon signaling pathway - Homo sapiens (human), Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Glutamatergic synapse - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hedgehog 'off' state, Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Infectious disease, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Integration of energy metabolism, Intracellular Signalling Through Adenosine Receptor A2a and Adenosine, Intracellular Signalling Through Adenosine Receptor A2b and Adenosine, Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone, Intracellular Signalling Through Histamine H2 Receptor and Histamine, Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin, Intracellular Signalling Through PGD2 receptor and Prostaglandin D2, Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin, LPA4-mediated signaling events, Leishmania infection, Leishmania parasite growth and survival, Long-term depression - Homo sapiens (human), Melanogenesis - Homo sapiens (human), Metabolism, Morphine addiction - Homo sapiens (human), Myometrial relaxation and contraction pathways, Ovarian steroidogenesis - Homo sapiens (human), Oxytocin signaling pathway - Homo sapiens (human), PKA activation in glucagon signalling, Pancreatic secretion - Homo sapiens (human), Parasitic Infection Pathways, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways Regulating Hippo Signaling, Pathways in cancer - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Plasma membrane estrogen receptor signaling, Platelet activation - Homo sapiens (human), Platelet homeostasis, Prostacyclin signalling through prostacyclin receptor, Purinergic signaling, Rap1 signaling pathway - Homo sapiens (human), Rapid glucocorticoid signaling, Regulation of insulin secretion, Regulation of lipolysis in adipocytes - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Renin secretion - Homo sapiens (human), Response of endothelial cells to shear stress, Salivary secretion - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Serotonin Receptor 4-6-7 and NR3C Signaling, Signal Transduction, Signaling by GPCR, Signaling by Hedgehog, TSH, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormone synthesis - Homo sapiens (human), Thyroid stimulating hormone (TSH) signaling pathway, Transport of small molecules, Vascular smooth muscle contraction - Homo sapiens (human), Vasopressin Regulation of Water Homeostasis, Vasopressin regulates renal water homeostasis via Aquaporins, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vibrio cholerae infection - Homo sapiens (human), activation of camp-dependent protein kinase pka, activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor, attenuation of gpcr signaling, cAMP signaling pathway - Homo sapiens (human), ccr3 signaling in eosinophils, chrebp regulation by carbohydrates and camp, corticosteroids and cardioprotection, cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway, gata3 participate in activating the th2 cytokine genes expression, how progesterone initiates the oocyte maturation, ion channels and their functional role in vascular endothelium, phospholipase c-epsilon pathway, regulation of ck1/cdk5 by type 1 glutamate receptors, regulation of spermatogenesis by crem, role of -arrestins in the activation and targeting of map kinases, roles of arrestin dependent recruitment of src kinases in gpcr signaling, signaling pathway from g-protein families, transcription factor creb and its extracellular signals
UniProt: Q5JWF2, P84996, P63092, O95467
Entrez ID: 2778
|
Does Knockout of SMIM24 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
SMIM24
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: SMIM24 (small integral membrane protein 24)
Type: protein-coding
Summary: Predicted to be located in membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: O75264
Entrez ID: 284422
|
Does Knockout of NUP214 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
NUP214
|
cell proliferation
|
T-lymphoma cell line
|
Gene: NUP214 (nucleoporin 214)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: RNA export from nucleus, intracellular protein transport, mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein export from nucleus, protein import into nucleus, protein transport, regulation of cell cycle, regulation of nucleocytoplasmic transport; MF: nuclear export signal receptor activity, nuclear localization sequence binding, protein binding, structural constituent of nuclear pore; CC: cytoplasmic side of nuclear pore, cytosol, nuclear envelope, nuclear pore, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, BMP receptor signaling, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, HuR (ELAVL1) binds and stabilizes mRNA, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Regulation of cytoplasmic and nuclear SMAD2/3 signaling, Regulation of mRNA stability by proteins that bind AU-rich elements, Rev-mediated nuclear export of HIV RNA, Role of Calcineurin-dependent NFAT signaling in lymphocytes, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TGF-beta Signaling Pathway, TGF_beta_Receptor, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, snRNP Assembly, sumoylation by ranbp2 regulates transcriptional repression, tRNA processing, tRNA processing in the nucleus
UniProt: P35658
Entrez ID: 8021
|
Does Knockout of DPH5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
DPH5
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DPH5 (diphthamide biosynthesis 5)
Type: protein-coding
Summary: This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: methylation, protein histidyl modification to diphthamide; MF: diphthine methyl ester synthase activity, methyltransferase activity, transferase activity; CC: cytosol
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Synthesis of diphthamide-EEF2, diphthamide biosynthesis
UniProt: Q9H2P9
Entrez ID: 51611
|
Does Knockout of ENO1 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
ENO1
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: ENO1 (enolase 1)
Type: protein-coding
Summary: This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: canonical glycolysis, gluconeogenesis, glycolytic process, negative regulation of DNA-templated transcription, negative regulation of cell growth, negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of ATP biosynthetic process, positive regulation of muscle contraction, positive regulation of plasminogen activation, response to virus; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, GTPase binding, RNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, cadherin binding, lyase activity, magnesium ion binding, metal ion binding, phosphopyruvate hydratase activity, protein binding, protein homodimerization activity, transcription corepressor activity, transcription corepressor binding; CC: M band, cell cortex, cell surface, cytoplasm, cytosol, extracellular exosome, extracellular space, membrane, nuclear outer membrane, nucleus, phosphopyruvate hydratase complex, plasma membrane
Pathways: Bacterial Infection Pathways, Computational Model of Aerobic Glycolysis, Disease, EGFR1, Fanconi-bickel syndrome, Fructose-1,6-diphosphatase deficiency, Gluconeogenesis, Glucose metabolism, Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycogenosis, Type VII. Tarui disease, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, HIF-1 signaling pathway - Homo sapiens (human), HIF-1-alpha transcription factor network, IL-18 signaling pathway, Infection with Mycobacterium tuberculosis, Infectious disease, Manipulation of host energy metabolism, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Notch signaling pathway, Pathways in clear cell renal cell carcinoma, Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), RNA degradation - Homo sapiens (human), Response of Mtb to phagocytosis, Triosephosphate isomerase, Validated targets of C-MYC transcriptional activation, Warburg Effect, gluconeogenesis, glycolysis, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P06733
Entrez ID: 2023
|
Does Knockout of B3GALT2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
B3GALT2
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: B3GALT2 (beta-1,3-galactosyltransferase 2)
Type: protein-coding
Summary: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene encodes a protein that functions in N-linked glycoprotein glycosylation and shows strict donor substrate specificity for UDP-galactose. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate derivative biosynthetic process, galactosylceramide biosynthetic process, lipid metabolic process, oligosaccharide biosynthetic process, protein O-linked glycosylation, protein glycosylation; MF: N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Blood group systems biosynthesis, Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human), Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: O43825
Entrez ID: 8707
|
Does Knockout of HLA-DQA2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
HLA-DQA2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: HLA-DQA2 (major histocompatibility complex, class II, DQ alpha 2)
Type: protein-coding
Summary: This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: adaptive immune response, antigen processing and presentation, antigen processing and presentation of exogenous peptide antigen via MHC class II, antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, immune response, immune system process, peptide antigen assembly with MHC class II protein complex, positive regulation of T cell activation, positive regulation of immune response; MF: MHC class II protein complex binding, MHC class II receptor activity, peptide antigen binding, protein binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, MHC class II protein complex, clathrin-coated endocytic vesicle membrane, endocytic vesicle membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, late endosome membrane, lumenal side of endoplasmic reticulum membrane, lysosomal membrane, lysosome, membrane, plasma membrane, trans-Golgi network membrane, transport vesicle membrane
Pathways: Adaptive Immune System, Allograft Rejection, Allograft rejection - Homo sapiens (human), Antigen processing and presentation - Homo sapiens (human), Asthma - Homo sapiens (human), Autoimmune thyroid disease - Homo sapiens (human), Cell adhesion molecules - Homo sapiens (human), Co-inhibition by PD-1, Cytokine Signaling in Immune system, Downstream TCR signaling, Ebola Virus Pathway on Host, Epstein-Barr virus infection - Homo sapiens (human), Generation of second messenger molecules, Graft-versus-host disease - Homo sapiens (human), Hematopoietic cell lineage - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inflammatory bowel disease - Homo sapiens (human), Influenza A - Homo sapiens (human), Interferon Signaling, Interferon gamma signaling, Intestinal immune network for IgA production - Homo sapiens (human), Leishmaniasis - Homo sapiens (human), MHC class II antigen presentation, Phagosome - Homo sapiens (human), Phosphorylation of CD3 and TCR zeta chains, Regulation of T cell activation by CD28 family, Rheumatoid arthritis - Homo sapiens (human), Staphylococcus aureus infection - Homo sapiens (human), Systemic lupus erythematosus - Homo sapiens (human), TCR signaling, Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Toxoplasmosis - Homo sapiens (human), Translocation of ZAP-70 to Immunological synapse, Tuberculosis - Homo sapiens (human), Type I diabetes mellitus - Homo sapiens (human), Viral myocarditis - Homo sapiens (human)
UniProt: P01906
Entrez ID: 3118
|
Does Knockout of PLK1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
PLK1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: PLK1 (polo like kinase 1)
Type: protein-coding
Summary: The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, Golgi inheritance, cell division, centrosome cycle, centrosome separation, double-strand break repair, double-strand break repair via alternative nonhomologous end joining, double-strand break repair via homologous recombination, establishment of mitotic spindle orientation, establishment of protein localization, female meiosis chromosome segregation, homologous chromosome segregation, metaphase/anaphase transition of mitotic cell cycle, microtubule bundle formation, mitotic G2 DNA damage checkpoint signaling, mitotic cell cycle, mitotic chromosome condensation, mitotic cytokinesis, mitotic nuclear membrane disassembly, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization, negative regulation of apoptotic process, negative regulation of double-strand break repair via homologous recombination, negative regulation of transcription by RNA polymerase II, nuclear division, nuclear membrane disassembly, peptidyl-serine phosphorylation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein localization to nucleus, positive regulation of proteolysis, positive regulation of ubiquitin protein ligase activity, positive regulation of ubiquitin-protein transferase activity, protein destabilization, protein localization to centrosome, protein localization to chromatin, protein localization to nuclear envelope, protein localization to organelle, protein localization to site of double-strand break, protein phosphorylation, protein ubiquitination, regulation of anaphase-promoting complex-dependent catabolic process, regulation of cell cycle, regulation of cell cycle process, regulation of cytokinesis, regulation of mitotic cell cycle, regulation of mitotic cell cycle phase transition, regulation of mitotic metaphase/anaphase transition, regulation of mitotic spindle assembly, regulation of protein localization to cell cortex, sister chromatid cohesion, synaptonemal complex disassembly; MF: ATP binding, anaphase-promoting complex binding, identical protein binding, kinase activity, magnesium ion binding, microtubule binding, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: centriolar satellite, centriole, centrosome, chromatin, chromosome, chromosome, centromeric region, condensed chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, microtubule cytoskeleton, midbody, mitotic spindle pole, nucleoplasm, nucleus, outer kinetochore, spindle, spindle microtubule, spindle midzone, spindle pole, synaptonemal complex
Pathways: 22q11.2 copy number variation syndrome, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, ATR signaling pathway, AURKA Activation by TPX2, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NIMA Kinases NEK9, NEK6, NEK7, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Centrosome maturation, Cilium Assembly, Condensation of Prophase Chromosomes, Cyclin A/B1/B2 associated events during G2/M transition, Developmental Biology, EML4 and NUDC in mitotic spindle formation, FOXM1 transcription factor network, FoxO family signaling, FoxO signaling pathway - Homo sapiens (human), G2/M Transition, Golgi Cisternae Pericentriolar Stack Reorganization, Integrated Cancer Pathway, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Metaphase/Anaphase Transition, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, Mitotic Telophase/Cytokinesis, Nuclear Envelope Breakdown, Oocyte meiosis - Homo sapiens (human), Organelle biogenesis and maintenance, PLK1 signaling events, Phosphorylation of Emi1, Phosphorylation of the APC/C, Polo-like kinase mediated events, Progesterone-mediated oocyte maturation - Homo sapiens (human), RHO GTPase Effectors, RHO GTPases Activate Formins, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of APC/C activators between G1/S and early anaphase, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation, Regulation of PLK1 Activity at G2/M Transition, Regulation of mitotic cell cycle, Regulation of toll-like receptor signaling pathway, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TNF-alpha signaling pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Validated transcriptional targets of TAp63 isoforms, p73 transcription factor network
UniProt: P53350
Entrez ID: 5347
|
Does Knockout of GATB in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
GATB
|
cell proliferation
|
Melanoma Cell Line
|
Gene: GATB (glutamyl-tRNA amidotransferase subunit B)
Type: protein-coding
Summary: Enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Located in mitochondrion. Part of glutamyl-tRNA(Gln) amidotransferase complex. Implicated in combined oxidative phosphorylation deficiency 41. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: glutaminyl-tRNAGln biosynthesis via transamidation, mitochondrial translation, translation; MF: ATP binding, carbon-nitrogen ligase activity, with glutamine as amido-N-donor, catalytic activity, glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, ligase activity, nucleotide binding, protein binding; CC: glutamyl-tRNA(Gln) amidotransferase complex, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), L-glutamine tRNA biosynthesis
UniProt: O75879
Entrez ID: 5188
|
Does Knockout of HOXA4 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
HOXA4
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: HOXA4 (homeobox A4)
Type: protein-coding
Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anatomical structure morphogenesis, anterior/posterior pattern specification, embryonic skeletal system morphogenesis, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nuclear body, nucleoplasm, nucleus
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Developmental Biology
UniProt: Q00056
Entrez ID: 3201
|
Does Knockout of EIF3F in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
EIF3F
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: EIF3F (eukaryotic translation initiation factor 3 subunit F)
Type: protein-coding
Summary: Enables deubiquitinase activity and identical protein binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; protein deubiquitination; and translational initiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: IRES-dependent viral translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, proteolysis, translation, translational initiation; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, identical protein binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, protein binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, membrane, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, VEGFA-VEGFR2 Signaling Pathway, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: O00303
Entrez ID: 8665
|
Does Knockout of CHMP2A in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
CHMP2A
|
cell proliferation
|
Cancer Cell Line
|
Gene: CHMP2A (charged multivesicular body protein 2A)
Type: protein-coding
Summary: CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: ESCRT III complex disassembly, autophagosome maturation, autophagy, endosome transport via multivesicular body sorting pathway, establishment of protein localization, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport, macroautophagy, membrane fission, membrane invagination, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, negative regulation of centriole elongation, nuclear membrane reassembly, nucleus organization, plasma membrane repair, positive regulation of exosomal secretion, protein homooligomerization, protein polymerization, protein transport, regulation of centrosome duplication, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex, viral release from host cell; MF: phosphatidylcholine binding, protein binding, protein domain specific binding; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, chromatin, cytosol, endosome, extracellular exosome, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, membrane coat, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleus, plasma membrane
Pathways: Autophagy, Budding and maturation of HIV virion, Cell Cycle, Cell Cycle, Mitotic, Disease, Early SARS-CoV-2 Infection Events, Endocytosis - Homo sapiens (human), Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Infectious disease, Late Phase of HIV Life Cycle, Late endosomal microautophagy, Lysosome Vesicle Biogenesis, M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Homo sapiens (human), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Sealing of the nuclear envelope (NE) by ESCRT-III, Translation of Replicase and Assembly of the Replication Transcription Complex, Vesicle-mediated transport, Viral Infection Pathways, trans-Golgi Network Vesicle Budding
UniProt: O43633
Entrez ID: 27243
|
Does Knockout of MALT1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
MALT1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: MALT1 (MALT1 paracaspase)
Type: protein-coding
Summary: This gene encodes a caspase-like protease that plays a role in BCL10-induced activation of NF-kappaB. The protein is a component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers NF-kappaB signaling and lymphoctye activation following antigen-receptor stimulation. Mutations in this gene result in immunodeficiency 12 (IMD12). This gene has been found to be recurrently rearranged in chromosomal translocations with other genes in mucosa-associated lymphoid tissue lymphomas, including a t(11;18)(q21;q21) translocation with the baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation with the immunoglobulin heavy chain locus (IGH-MALT1). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2018].
Gene Ontology: BP: B cell activation, B-1 B cell differentiation, T cell proliferation, T cell receptor signaling pathway, cellular response to lipopolysaccharide, defense response, immune system process, innate immune response, lipopolysaccharide-mediated signaling pathway, negative regulation of apoptotic process, nuclear export, positive regulation of T cell activation, positive regulation of T cell cytokine production, positive regulation of T-helper 17 cell differentiation, positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, positive regulation of canonical NF-kappaB signal transduction, positive regulation of immune effector process, positive regulation of interleukin-1 beta production, positive regulation of interleukin-2 production, positive regulation of multicellular organismal process, positive regulation of protein ubiquitination, proteolysis, proteolysis involved in protein catabolic process, regulation of T cell receptor signaling pathway, regulation of apoptotic process, regulation of signal transduction, response to fungus; MF: cysteine-type endopeptidase activity, endopeptidase activator activity, endopeptidase activity, hydrolase activity, identical protein binding, kinase activator activity, peptidase activity, protease binding, protein binding, small molecule binding, ubiquitin-protein transferase activity; CC: CBM complex, cytoplasm, cytosol, fibrillar center, nucleus, perinuclear region of cytoplasm, polkadots, protein-containing complex
Pathways: 22q11.2 copy number variation syndrome, B Cell Receptor Signaling Pathway, B cell receptor signaling pathway - Homo sapiens (human), BCR, BCR signaling pathway, C-type lectin receptor signaling pathway - Homo sapiens (human), Canonical NF-kappaB pathway, Modulators of TCR signaling and T cell activation, NF-kappa B signaling pathway - Homo sapiens (human), Shigellosis - Homo sapiens (human), T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, T-cell receptor (TCR) signaling pathway, TCR, TCR signaling in naïve CD4+ T cells, TCR signaling in naïve CD8+ T cells, Tuberculosis - Homo sapiens (human)
UniProt: Q9UDY8
Entrez ID: 10892
|
Does Knockout of QRFPR in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
QRFPR
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: QRFPR (pyroglutamylated RFamide peptide receptor)
Type: protein-coding
Summary: Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in non-motile cilium. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to hormone stimulus, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled receptor activity, neuropeptide Y receptor activity, protein binding; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Orexin and neuropeptides FF and QRFP bind to their respective receptors, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q96P65
Entrez ID: 84109
|
Does Knockout of CHMP2A in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
CHMP2A
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CHMP2A (charged multivesicular body protein 2A)
Type: protein-coding
Summary: CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: ESCRT III complex disassembly, autophagosome maturation, autophagy, endosome transport via multivesicular body sorting pathway, establishment of protein localization, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport, macroautophagy, membrane fission, membrane invagination, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, negative regulation of centriole elongation, nuclear membrane reassembly, nucleus organization, plasma membrane repair, positive regulation of exosomal secretion, protein homooligomerization, protein polymerization, protein transport, regulation of centrosome duplication, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex, viral release from host cell; MF: phosphatidylcholine binding, protein binding, protein domain specific binding; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, chromatin, cytosol, endosome, extracellular exosome, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, membrane coat, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleus, plasma membrane
Pathways: Autophagy, Budding and maturation of HIV virion, Cell Cycle, Cell Cycle, Mitotic, Disease, Early SARS-CoV-2 Infection Events, Endocytosis - Homo sapiens (human), Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Infectious disease, Late Phase of HIV Life Cycle, Late endosomal microautophagy, Lysosome Vesicle Biogenesis, M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Homo sapiens (human), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Sealing of the nuclear envelope (NE) by ESCRT-III, Translation of Replicase and Assembly of the Replication Transcription Complex, Vesicle-mediated transport, Viral Infection Pathways, trans-Golgi Network Vesicle Budding
UniProt: O43633
Entrez ID: 27243
|
Does Knockout of SLC4A1AP in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
SLC4A1AP
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: SLC4A1AP (solute carrier family 4 member 1 adaptor protein)
Type: protein-coding
Summary: Predicted to enable mRNA binding activity. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: mRNA binding, protein binding; CC: cytoplasm, nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q9BWU0
Entrez ID: 22950
|
Does Knockout of FGFR3 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
FGFR3
|
response to chemicals
|
Melanoma Cell Line
|
Gene: FGFR3 (fibroblast growth factor receptor 3)
Type: protein-coding
Summary: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: MAPK cascade, apoptotic process, bone maturation, bone mineralization, bone morphogenesis, cartilage development, cell population proliferation, cell surface receptor signaling pathway via JAK-STAT, cell-cell signaling, chondrocyte differentiation, chondrocyte proliferation, endochondral bone growth, endochondral ossification, fibroblast growth factor receptor apoptotic signaling pathway, fibroblast growth factor receptor signaling pathway, negative regulation of developmental growth, ossification, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAPK cascade, positive regulation of cell population proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of phospholipase activity, positive regulation of tyrosine phosphorylation of STAT protein, skeletal system development; MF: ATP binding, fibroblast growth factor binding, fibroblast growth factor receptor activity, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: Golgi apparatus, cell surface, cytoplasmic vesicle, endoplasmic reticulum, extracellular region, focal adhesion, membrane, plasma membrane, receptor complex, transport vesicle
Pathways: Bladder cancer, Bladder cancer - Homo sapiens (human), Calcium signaling pathway - Homo sapiens (human), Central carbon metabolism in cancer - Homo sapiens (human), Constitutive Signaling by Aberrant PI3K in Cancer, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downstream signaling of activated FGFR3, EGFR Tyrosine Kinase Inhibitor Resistance, ESC Pluripotency Pathways, Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, Endocytosis - Homo sapiens (human), Endometrial cancer, FGF signaling pathway, FGF23 signaling in hypophosphatemic rickets and related disorders, FGFR3 ligand binding and activation, FGFR3 mutant receptor activation, FGFR3 signaling in chondrocyte proliferation and terminal differentiation, FGFR3b ligand binding and activation, FRS-mediated FGFR3 signaling, Fibroblast growth factor-1, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Head and Neck Squamous Cell Carcinoma, Hippo-Merlin Signaling Dysregulation, IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, MicroRNAs in cancer - Homo sapiens (human), NOTCH1 regulation of endothelial cell calcification, Negative regulation of FGFR3 signaling, Negative regulation of the PI3K/AKT network, Neural Crest Differentiation, Osteoblast differentiation, PI-3K cascade:FGFR3, PI3K Cascade, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways Regulating Hippo Signaling, Pathways in cancer - Homo sapiens (human), Phospholipase C-mediated cascade; FGFR3, RAF/MAP kinase cascade, Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), SHC-mediated cascade:FGFR3, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR3, Signaling by FGFR3 in disease, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by activated point mutants of FGFR3, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Syndecan-1-mediated signaling events, Syndecan-2-mediated signaling events, Syndecan-3-mediated signaling events
UniProt: P22607
Entrez ID: 2261
|
Does Knockout of LAMTOR3 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
LAMTOR3
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: LAMTOR3 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 3)
Type: protein-coding
Summary: This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: TORC1 signaling, cellular response to amino acid stimulus, intracellular protein localization, positive regulation of MAPK cascade, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of intracellular signal transduction, protein localization to cell junction, regulation of TOR signaling; MF: guanyl-nucleotide exchange factor activity, kinase activator activity, molecular adaptor activity, protein binding; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, cytoplasm, endosome, endosome membrane, extracellular exosome, focal adhesion, late endosome, late endosome membrane, lysosomal membrane, membrane, plasma membrane, specific granule membrane, tertiary granule membrane
Pathways: Amino acids regulate mTORC1, Autophagy, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gastrin signaling pathway, Gene expression (Transcription), Generic Transcription Pathway, Immune System, Innate Immune System, Intracellular signaling by second messengers, MAP2K and MAPK activation, MAPK Cascade, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, MTOR signalling, Macroautophagy, Melanoma, Neutrophil degranulation, PIP3 activates AKT signaling, PTEN Regulation, RAF/MAP kinase cascade, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Homo sapiens (human), mTORC1-mediated signalling
UniProt: Q9UHA4
Entrez ID: 8649
|
Does Knockout of SPACA7 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
SPACA7
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SPACA7 (sperm acrosome associated 7)
Type: protein-coding
Summary: Predicted to act upstream of or within negative regulation of cell adhesion and single fertilization. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: acrosomal lumen, acrosomal vesicle, cytoplasmic vesicle, extracellular region
Pathways:
UniProt: Q96KW9
Entrez ID: 122258
|
Does Knockout of KLHL31 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
KLHL31
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: KLHL31 (kelch like family member 31)
Type: protein-coding
Summary: Involved in negative regulation of JNK cascade and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of JNK cascade, negative regulation of protein phosphorylation; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9H511
Entrez ID: 401265
|
Does Knockout of KCNS3 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
KCNS3
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: KCNS3 (potassium voltage-gated channel modifier subfamily S member 3)
Type: protein-coding
Summary: Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of potassium ion transmembrane transport, transmembrane transport; MF: delayed rectifier potassium channel activity, monoatomic ion channel activity, potassium channel activity, potassium channel regulator activity, voltage-gated potassium channel activity; CC: Golgi apparatus, cytoplasm, cytosol, membrane, monoatomic ion channel complex, plasma membrane, voltage-gated potassium channel complex
Pathways: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Integration of energy metabolism, Metabolism, Neuronal System, Potassium Channels, Regulation of insulin secretion, Voltage gated Potassium channels
UniProt: Q9BQ31
Entrez ID: 3790
|
Does Knockout of DPPA4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
DPPA4
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: DPPA4 (developmental pluripotency associated 4)
Type: protein-coding
Summary: This gene encodes a nuclear factor that is involved in the maintenance of pluripotency in stem cells and essential for embryogenesis. The encoded protein has a scaffold-attachment factor A/B, acinus and PIAS (SAP) domain that binds DNA and is thought to modify chromatin. Mice with a homozygous knockout of the orthologous gene die during late embryonic development or within hours after birth. Knockout embryos are normal in size at embryonic day 18.5 but exhibit skeletal and lung tissue abnormalities. This gene, when mutated, is highly expressed in embryonal carcinomas, pluripotent germ cell tumors, and other cancers and is thought to play an important role in tumor progression. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
Gene Ontology: BP: lung-associated mesenchyme development, system development; MF: chromatin binding, protein binding; CC: nucleoplasm, nucleus
Pathways: Developmental Biology, Maternal to zygotic transition (MZT), POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation, Transcriptional regulation of pluripotent stem cells, Zygotic genome activation (ZGA)
UniProt: Q7L190
Entrez ID: 55211
|
Does Knockout of SUPV3L1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
SUPV3L1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: SUPV3L1 (Suv3 like RNA helicase)
Type: protein-coding
Summary: Enables helicase activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including mitochondrial RNA metabolic process; mitochondrion morphogenesis; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrial nucleoid and nucleus. Part of mitochondrial degradosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA recombination, RNA catabolic process, mitochondrial RNA 3'-end processing, mitochondrial RNA catabolic process, mitochondrial RNA surveillance, mitochondrial mRNA catabolic process, mitochondrial mRNA surveillance, mitochondrial ncRNA surveillance, mitochondrion organization, negative regulation of apoptotic process, positive regulation of cell growth, positive regulation of mitochondrial RNA catabolic process; MF: 3'-5' RNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding, protein homodimerization activity; CC: mitochondrial degradosome, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleus
Pathways: Metabolism of RNA, Mitochondrial RNA degradation
UniProt: Q8IYB8
Entrez ID: 6832
|
Does Knockout of SEPSECS in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
SEPSECS
|
cell proliferation
|
Cancer Cell Line
|
Gene: SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)
Type: protein-coding
Summary: The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011].
Gene Ontology: BP: conversion of seryl-tRNAsec to selenocys-tRNAsec, selenocysteine incorporation, translation; MF: O-phosphoseryl-tRNA(Sec) selenium transferase activity, RNA binding, protein binding, tRNA binding, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Metabolism, Metabolism of amino acids and derivatives, Selenoamino acid metabolism, Selenocompound metabolism - Homo sapiens (human), Selenocysteine synthesis, selenocysteine biosynthesis
UniProt: Q9HD40
Entrez ID: 51091
|
Does Knockout of DAD1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
DAD1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DAD1 (defender against cell death 1)
Type: protein-coding
Summary: DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, blastocyst development, negative regulation of apoptotic process, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, regulation of protein stability; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Asparagine N-linked glycosylation, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Disease, Immune System, Infectious disease, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Various types of N-glycan biosynthesis - Homo sapiens (human), Viral Infection Pathways
UniProt: P61803
Entrez ID: 1603
|
Does Knockout of TBC1D3 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
TBC1D3
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: TBC1D3 (TBC1 domain family member 3)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Predicted to be located in early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase activator activity; CC: early endosome membrane, endosome, membrane, plasma membrane
Pathways: Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q6IPX1, Q8IZP1
Entrez ID: 729873
|
Does Knockout of NOC2L in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
NOC2L
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: NOC2L (NOC2 like nucleolar associated transcriptional repressor)
Type: protein-coding
Summary: Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: apoptotic process, cellular response to UV, negative regulation of B cell apoptotic process, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of transcription by RNA polymerase II, ribosomal large subunit biogenesis, transcription initiation-coupled chromatin remodeling; MF: DNA-binding transcription factor binding, RNA binding, chromatin binding, histone binding, nucleosome binding, protein binding, transcription corepressor activity; CC: Noc1p-Noc2p complex, Noc2p-Noc3p complex, chromosome, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53, Validated transcriptional targets of TAp63 isoforms
UniProt: Q9Y3T9
Entrez ID: 26155
|
Does Knockout of SUPV3L1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
SUPV3L1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SUPV3L1 (Suv3 like RNA helicase)
Type: protein-coding
Summary: Enables helicase activity; nucleic acid binding activity; and protein homodimerization activity. Involved in several processes, including mitochondrial RNA metabolic process; mitochondrion morphogenesis; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrial nucleoid and nucleus. Part of mitochondrial degradosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA recombination, RNA catabolic process, mitochondrial RNA 3'-end processing, mitochondrial RNA catabolic process, mitochondrial RNA surveillance, mitochondrial mRNA catabolic process, mitochondrial mRNA surveillance, mitochondrial ncRNA surveillance, mitochondrion organization, negative regulation of apoptotic process, positive regulation of cell growth, positive regulation of mitochondrial RNA catabolic process; MF: 3'-5' RNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, nucleotide binding, protein binding, protein homodimerization activity; CC: mitochondrial degradosome, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleus
Pathways: Metabolism of RNA, Mitochondrial RNA degradation
UniProt: Q8IYB8
Entrez ID: 6832
|
Does Knockout of KREMEN2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
KREMEN2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: KREMEN2 (kringle containing transmembrane protein 2)
Type: protein-coding
Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: Wnt signaling pathway, limb development, negative regulation of ossification, signal transduction; CC: early endosome membrane, membrane, plasma membrane
Pathways: Disease, Diseases of signal transduction by growth factor receptors and second messengers, Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Presenilin action in Notch and Wnt signaling, Signal Transduction, Signaling by LRP5 mutants , Signaling by WNT, Signaling by WNT in cancer, TCF dependent signaling in response to WNT, Wnt signaling network, inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages, multi-step regulation of transcription by pitx2, segmentation clock, wnt lrp6 signalling, wnt signaling pathway
UniProt: Q8NCW0
Entrez ID: 79412
|
Does Activation of KLHL31 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
KLHL31
|
protein/peptide accumulation
|
T cell
|
Gene: KLHL31 (kelch like family member 31)
Type: protein-coding
Summary: Involved in negative regulation of JNK cascade and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of JNK cascade, negative regulation of protein phosphorylation; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9H511
Entrez ID: 401265
|
Does Knockout of CIAO1 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
CIAO1
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: CIAO1 (cytosolic iron-sulfur assembly component 1)
Type: protein-coding
Summary: Involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Located in cytoplasm. Part of CIA complex and MMXD complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromosome segregation, iron-sulfur cluster assembly, protein maturation, regulation of transcription by RNA polymerase II; CC: MMXD complex, cytoplasm, cytosolic [4Fe-4S] assembly targeting complex
Pathways: Cytosolic iron-sulfur cluster assembly, Metabolism
UniProt: O76071
Entrez ID: 9391
|
Does Knockout of MPL in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
MPL
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: MPL (MPL proto-oncogene, thrombopoietin receptor)
Type: protein-coding
Summary: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: basophil homeostasis, cellular response to hypoxia, eosinophil homeostasis, monocyte homeostasis, neutrophil homeostasis, platelet formation, positive regulation of lymphocyte proliferation, positive regulation of platelet formation, thrombopoietin-mediated signaling pathway; MF: cytokine receptor activity, protein binding, thrombopoietin receptor activity; CC: Golgi apparatus, cell surface, external side of plasma membrane, membrane, neuronal cell body, nuclear membrane, plasma membrane
Pathways: 16p11.2 distal deletion syndrome, Cytokine-cytokine receptor interaction - Homo sapiens (human), Hemostasis, JAK-STAT signaling pathway - Homo sapiens (human), Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Regulatory circuits of the STAT3 signaling pathway, tpo signaling pathway
UniProt: P40238
Entrez ID: 4352
|
Does Knockout of RANBP10 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
RANBP10
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RANBP10 (RAN binding protein 10)
Type: protein-coding
Summary: RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cytoskeleton organization, microtubule cytoskeleton organization; MF: beta-tubulin binding, guanyl-nucleotide exchange factor activity, protein binding, small GTPase binding; CC: cytoplasm, cytosol, microtubule cytoskeleton, nucleus, ubiquitin ligase complex
Pathways: Ciliary landscape, MET activates RAS signaling, Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
UniProt: Q6VN20
Entrez ID: 57610
|
Does Activation of GCLM in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
GCLM
|
protein/peptide accumulation
|
T cell
|
Gene: GCLM (glutamate-cysteine ligase modifier subunit)
Type: protein-coding
Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: apoptotic mitochondrial changes, blood vessel diameter maintenance, cellular response to fibroblast growth factor stimulus, cellular response to follicle-stimulating hormone stimulus, cellular response to glucose stimulus, cellular response to hepatocyte growth factor stimulus, cellular response to leukemia inhibitory factor, cellular response to thyroxine stimulus, cysteine metabolic process, glutamate metabolic process, glutathione biosynthetic process, glutathione metabolic process, hepatic stellate cell activation, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of neuron apoptotic process, regulation of mitochondrial depolarization, response to activity, response to human chorionic gonadotropin, response to nitrosative stress, response to nutrient, response to oxidative stress, response to xenobiotic stimulus; MF: glutamate-cysteine ligase activity, glutamate-cysteine ligase catalytic subunit binding, glutamate-cysteine ligase regulator activity, protein binding, protein-containing complex binding; CC: cytosol, glutamate-cysteine ligase complex
Pathways: γ-glutamyl cycle, 2-Hydroxyglutric Aciduria (D And L Form), 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency, 5-Oxoprolinuria, 5-oxoprolinase deficiency, Amino Acid metabolism, Beta-mercaptolactate-cysteine disulfiduria, Biological oxidations, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cysteine Metabolism, Cysteine and methionine metabolism - Homo sapiens (human), Cystinosis, ocular nonnephropathic, Defective GCLC causes HAGGSD, Disease, Diseases of metabolism, Ferroptosis, Ferroptosis - Homo sapiens (human), Gamma-Glutamyltransferase Deficiency, Gamma-glutamyl-transpeptidase deficiency, Glutamate Metabolism, Glutathione Metabolism, Glutathione Synthetase Deficiency, Glutathione conjugation, Glutathione metabolism, Glutathione metabolism - Homo sapiens (human), Glutathione synthesis and recycling, Homocarnosinosis, Hyperinsulinism-Hyperammonemia Syndrome, KEAP1-NFE2L2 pathway, Metabolic disorders of biological oxidation enzymes, Metabolism, NFE2L2 regulating anti-oxidant/detoxification enzymes, NRF2 pathway, NRF2-ARE regulation, Nuclear Receptors Meta-Pathway, Nuclear events mediated by NFE2L2, One-carbon metabolism and related pathways, Phase II - Conjugation of compounds, Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, Phytochemical activity on NRF2 transcriptional activation, Succinic semialdehyde dehydrogenase deficiency, Trans-sulfuration and one-carbon metabolism, Trans-sulfuration pathway, glutathione biosynthesis
UniProt: P48507
Entrez ID: 2730
|
Does Knockout of GJB7 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
GJB7
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: GJB7 (gap junction protein beta 7)
Type: protein-coding
Summary: Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell communication, cell-cell signaling, transmembrane transport; MF: gap junction channel activity; CC: anchoring junction, connexin complex, gap junction, membrane, plasma membrane
Pathways: Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q6PEY0
Entrez ID: 375519
|
Does Knockout of SPATA19 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
SPATA19
|
response to chemicals
|
Melanoma Cell Line
|
Gene: SPATA19 (spermatogenesis associated 19)
Type: protein-coding
Summary: Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, sperm mitochondrion organization, spermatogenesis; CC: cell projection, cilium, membrane, mitochondrial outer membrane, mitochondrion, motile cilium, sperm flagellum, sperm midpiece
Pathways:
UniProt: Q7Z5L4
Entrez ID: 219938
|
Does Knockout of TGOLN2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
TGOLN2
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: TGOLN2 (trans-golgi network protein 2)
Type: protein-coding
Summary: This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: CC: Golgi apparatus, clathrin-coated endocytic vesicle membrane, endoplasmic reticulum lumen, endosome, membrane, nucleoplasm, plasma membrane, trans-Golgi network, trans-Golgi network transport vesicle, transport vesicle
Pathways:
UniProt: O43493
Entrez ID: 10618
|
Does Knockout of SNAPC3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
SNAPC3
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: SNAPC3 (small nuclear RNA activating complex polypeptide 3)
Type: protein-coding
Summary: Predicted to enable RNA polymerase III type 3 promoter sequence-specific DNA binding activity and bent DNA binding activity. Predicted to contribute to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and core promoter sequence-specific DNA binding activity. Predicted to be involved in snRNA transcription by RNA polymerase II and snRNA transcription by RNA polymerase III. Located in nuclear body and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: snRNA transcription, snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III, transcription by RNA polymerase II, transcription by RNA polymerase III; MF: DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase III general transcription initiation factor activity, RNA polymerase III type 3 promoter sequence-specific DNA binding, bent DNA binding, core promoter sequence-specific DNA binding, protein binding; CC: nuclear body, nucleolus, nucleoplasm, nucleus, snRNA-activating protein complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes
UniProt: Q92966
Entrez ID: 6619
|
Does Knockout of PLPBP in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
PLPBP
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: PLPBP (pyridoxal phosphate binding protein)
Type: protein-coding
Summary: This gene encodes a pyridoxal 5'-phosphate binding protein involved in the homeostatic regulation of intracellular pyridoxal 5'-phosphate. This gene has a tumor suppressive effect on hepatocellular carcinoma and other solid tumors of epithelial origin. Naturally occurring mutations in this gene are associated with a pyridoxine-dependent epilepsy. [provided by RefSeq, Mar 2017].
Gene Ontology: MF: pyridoxal phosphate binding; CC: cytoplasm, cytosol, mitochondrion
Pathways:
UniProt: O94903
Entrez ID: 11212
|
Does Knockout of RPS23 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
RPS23
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: RPS23 (ribosomal protein S23)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant amino acid similarity with S. cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maintenance of translational fidelity, ribosomal small subunit biogenesis, stress granule assembly, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Post-translational protein modification, Protein hydroxylation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62266
Entrez ID: 6228
|
Does Knockout of DPM3 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
DPM3
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: DPM3 (dolichyl-phosphate mannosyltransferase subunit 3, regulatory)
Type: protein-coding
Summary: Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: dolichol phosphate mannose biosynthetic process, protein O-linked glycosylation via mannose, protein glycosylation; MF: endoplasmic reticulum-plasma membrane adaptor activity, enzyme activator activity, protein binding; CC: dolichol-phosphate-mannose synthase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: N-Glycan biosynthesis - Homo sapiens (human), dolichyl-diphosphooligosaccharide biosynthesis
UniProt: Q9P2X0
Entrez ID: 54344
|
Does Knockout of PWWP2B in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
PWWP2B
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: PWWP2B (PWWP domain containing 2B)
Type: protein-coding
Summary: Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin remodeling, positive regulation of transcription elongation by RNA polymerase II, regulation of cold-induced thermogenesis; MF: NuRD complex binding, protein binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q6NUJ5
Entrez ID: 170394
|
Does Knockout of NGDN in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
NGDN
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: NGDN (neuroguidin)
Type: protein-coding
Summary: Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), regulation of translation, ribosomal small subunit biogenesis; MF: RNA binding, protein binding; CC: axon, cell projection, chromosome, chromosome, centromeric region, cytoplasm, dendrite, filopodium, mitochondrion, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways:
UniProt: Q8NEJ9
Entrez ID: 25983
|
Does Knockout of PSME3 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
PSME3
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: PSME3 (proteasome activator subunit 3)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012].
Gene Ontology: BP: apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, regulation of G1/S transition of mitotic cell cycle, regulation of proteasomal protein catabolic process; MF: MDM2/MDM4 family protein binding, endopeptidase activator activity, identical protein binding, p53 binding, protein binding; CC: ciliary basal body, cilium, cytoplasm, cytosol, membrane, nucleoplasm, nucleus, proteasome activator complex, proteasome complex
Pathways: Antigen processing and presentation - Homo sapiens (human), Hepatitis C - Homo sapiens (human), Metabolism of proteins, Post-translational protein modification, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly
UniProt: P61289
Entrez ID: 10197
|
Does Knockout of RACK1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
RACK1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: RACK1 (receptor for activated C kinase 1)
Type: protein-coding
Summary: Enables several functions, including cyclin binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulation of cellular protein metabolic process; and regulation of signal transduction. Located in several cellular components, including midbody; perinuclear region of cytoplasm; and phagocytic cup. Part of IRE1-RACK1-PP2A complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, cellular response to glucose stimulus, cellular response to growth factor stimulus, cytoplasmic translation, gastrulation, negative regulation of Wnt signaling pathway, negative regulation of cell growth, negative regulation of endoplasmic reticulum unfolded protein response, negative regulation of gene expression, negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide, negative regulation of phagocytosis, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of protein binding, negative regulation of smoothened signaling pathway, negative regulation of translation, negative regulation of translational frameshifting, pigmentation, positive regulation of GTPase activity, positive regulation of Golgi to plasma membrane protein transport, positive regulation of apoptotic process, positive regulation of cell migration, positive regulation of gastrulation, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of mitochondrial depolarization, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein phosphorylation, positive regulation of protein-containing complex assembly, protein ubiquitination, regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of cell cycle, regulation of cell division, regulation of establishment of cell polarity, regulation of protein localization, regulation of translation, rescue of stalled ribosome, rhythmic process, translation; MF: BH3 domain binding, RNA binding, SH2 domain binding, cadherin binding, cyclin binding, cysteine-type endopeptidase activator activity involved in apoptotic process, enzyme activator activity, enzyme binding, identical protein binding, ion channel inhibitor activity, molecular adaptor activity, protein binding, protein homodimerization activity, protein kinase C binding, protein phosphatase binding, protein serine/threonine kinase inhibitor activity, protein tyrosine kinase inhibitor activity, receptor tyrosine kinase binding, ribosome binding, signaling adaptor activity, signaling receptor binding, translation regulator activity; CC: IRE1-RACK1-PP2A complex, cell body, cell projection, cytoplasm, cytosol, cytosolic small ribosomal subunit, dendrite, extracellular exosome, membrane, midbody, mitochondrion, neuron projection, neuronal cell body, nucleoplasm, nucleus, perikaryon, perinuclear region of cytoplasm, phagocytic cup, plasma membrane, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Adherens junctions interactions, Androgen receptor signaling pathway, AndrogenReceptor, Brain-derived neurotrophic factor (BDNF) signaling pathway, CXCR4-mediated signaling events, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Death Receptor Signaling, Degradation of CDH1, Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, IGF1 pathway, IL3, IL5, Interferon type I signaling pathways, Measles - Homo sapiens (human), Regulation of Androgen receptor activity, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of TNFR1 signaling, Signal Transduction, Syndecan-2-mediated signaling events, TNF receptor signaling pathway , TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR1-mediated ceramide production, TNFalpha, VEGFA-VEGFR2 Signaling Pathway, Validated transcriptional targets of deltaNp63 isoforms, p73 transcription factor network
UniProt: P63244
Entrez ID: 10399
|
Does Knockout of EXOC5 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
EXOC5
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: EXOC5 (exocyst complex component 5)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi to plasma membrane transport, epithelial cell apoptotic process, establishment of planar polarity, exocytosis, membrane fission, mitotic cytokinesis, non-motile cilium assembly, post-Golgi vesicle-mediated transport, protein localization to plasma membrane, protein transport, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; MF: protein binding, small GTPase binding; CC: cytoplasm, cytosol, exocyst, midbody
Pathways: Arf6 trafficking events, Cargo trafficking to the periciliary membrane, Ciliary landscape, Cilium Assembly, Insulin Pathway, Insulin processing, Membrane Trafficking, Metabolism of proteins, Organelle biogenesis and maintenance, Peptide hormone metabolism, Salmonella infection - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, Vesicle-mediated transport, VxPx cargo-targeting to cilium
UniProt: O00471
Entrez ID: 10640
|
Does Knockout of RPL36 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
RPL36
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: RPL36 (ribosomal protein L36)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L36E family of ribosomal proteins. It is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, membrane, nucleolus, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y3U8
Entrez ID: 25873
|
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