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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of KMT2A in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
KMT2A
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: KMT2A (lysine methyltransferase 2A)
Type: protein-coding
Summary: This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010].
Gene Ontology: BP: T-helper 2 cell differentiation, anterior/posterior pattern specification, apoptotic process, cellular response to transforming growth factor beta stimulus, chromatin organization, circadian regulation of gene expression, cognition, definitive hemopoiesis, embryonic hemopoiesis, epigenetic regulation of gene expression, exploration behavior, fibroblast proliferation, homeostasis of number of cells within a tissue, immune system process, membrane depolarization, methylation, negative regulation of DNA methylation-dependent heterochromatin formation, negative regulation of fibroblast proliferation, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, post-embryonic development, protein modification process, protein-containing complex assembly, regulation of DNA-templated transcription, regulation of gene expression, regulation of short-term neuronal synaptic plasticity, response to light stimulus, response to potassium ion, rhythmic process, spleen development, transcription initiation-coupled chromatin remodeling, visual learning; MF: DNA binding, chromatin binding, histone H3K4 methyltransferase activity, histone H3K4 monomethyltransferase activity, histone H3K4 trimethyltransferase activity, identical protein binding, metal ion binding, methyltransferase activity, minor groove of adenine-thymine-rich DNA binding, protein binding, protein homodimerization activity, protein-cysteine methyltransferase activity, transferase activity, unmethylated CpG binding, zinc ion binding; CC: MLL1 complex, MLL1/2 complex, cytosol, histone methyltransferase complex, nucleoplasm, nucleus
Pathways: Cushing syndrome - Homo sapiens (human), Histone Modifications, Lysine degradation - Homo sapiens (human), Senescence and Autophagy in Cancer, Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: Q03164
Entrez ID: 4297
|
Does Knockout of BZW2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
BZW2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: BZW2 (basic leucine zipper and W2 domains 2)
Type: protein-coding
Summary: Enables cadherin binding activity. Predicted to be involved in cell differentiation and nervous system development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of translation, regulation of translational initiation; MF: cadherin binding, protein binding; CC: cytoplasm, membrane
Pathways:
UniProt: Q9Y6E2
Entrez ID: 28969
|
Does Knockout of USPL1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
USPL1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: USPL1 (ubiquitin specific peptidase like 1)
Type: protein-coding
Summary: Enables SUMO binding activity and SUMO-specific isopeptidase activity. Involved in several processes, including Cajal body organization; protein desumoylation; and snRNA transcription. Located in Cajal body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Cajal body organization, cell population proliferation, protein desumoylation, proteolysis, snRNA transcription; MF: SUMO binding, cysteine-type peptidase activity, deSUMOylase activity, hydrolase activity, peptidase activity, protein binding, ubiquitin binding; CC: Cajal body, extracellular space, nucleus
Pathways:
UniProt: Q5W0Q7
Entrez ID: 10208
|
Does Knockout of LYN in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
LYN
|
cell proliferation
|
Bladder Carcinoma
|
Gene: LYN (LYN proto-oncogene, Src family tyrosine kinase)
Type: protein-coding
Summary: This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: B cell homeostasis, B cell proliferation, B cell receptor signaling pathway, C-X-C chemokine receptor CXCR4 signaling pathway, DNA damage checkpoint signaling, DNA damage response, Fc receptor mediated inhibitory signaling pathway, Fc receptor mediated stimulatory signaling pathway, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, T cell costimulation, adaptive immune response, autophagy, cell morphogenesis, cell surface receptor protein tyrosine kinase signaling pathway, cellular response to heat, cellular response to lipid, cellular response to retinoic acid, dendritic cell differentiation, eosinophil differentiation, ephrin receptor signaling pathway, erythrocyte differentiation, fatty acid transport, growth hormone receptor signaling pathway via JAK-STAT, hematopoietic progenitor cell differentiation, hemopoiesis, histamine secretion by mast cell, immune response-regulating cell surface receptor signaling pathway, immune system process, inflammatory response, innate immune response, innate immune response-activating signaling pathway, interleukin-5-mediated signaling pathway, intracellular signal transduction, leukocyte migration, lipopolysaccharide-mediated signaling pathway, negative regulation of B cell proliferation, negative regulation of B cell receptor signaling pathway, negative regulation of ERK1 and ERK2 cascade, negative regulation of MAP kinase activity, negative regulation of cell population proliferation, negative regulation of immune response, negative regulation of inflammatory response to antigenic stimulus, negative regulation of intracellular signal transduction, negative regulation of mast cell proliferation, negative regulation of myeloid leukocyte differentiation, negative regulation of protein phosphorylation, negative regulation of toll-like receptor 2 signaling pathway, negative regulation of toll-like receptor 4 signaling pathway, neuroinflammatory response, neuron projection development, oligodendrocyte development, peptidyl-tyrosine phosphorylation, platelet degranulation, positive regulation of Fc receptor mediated stimulatory signaling pathway, positive regulation of MAPK cascade, positive regulation of amyloid precursor protein catabolic process, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of dendritic cell apoptotic process, positive regulation of glial cell proliferation, positive regulation of mast cell proliferation, positive regulation of neuron projection development, positive regulation of oligodendrocyte progenitor proliferation, positive regulation of phosphorylation, positive regulation of protein localization to plasma membrane, protein autophosphorylation, protein phosphorylation, regulation of B cell apoptotic process, regulation of B cell receptor signaling pathway, regulation of ERK1 and ERK2 cascade, regulation of cell adhesion mediated by integrin, regulation of cytokine production, regulation of erythrocyte differentiation, regulation of inflammatory response, regulation of mast cell activation, regulation of mast cell degranulation, regulation of monocyte chemotaxis, regulation of platelet aggregation, regulation of protein phosphorylation, regulation of release of sequestered calcium ion into cytosol, response to amino acid, response to axon injury, response to carbohydrate, response to hormone, response to insulin, response to peptide hormone, response to sterol depletion, response to stress, response to toxic substance, response to xenobiotic stimulus, signal transduction, stimulatory C-type lectin receptor signaling pathway, tolerance induction to self antigen, toll-like receptor 4 signaling pathway; MF: ATP binding, SH3 domain binding, enzyme binding, ephrin receptor binding, gamma-tubulin binding, glycosphingolipid binding, integrin binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, phosphatidylinositol 3-kinase activator activity, phosphoprotein binding, phosphorylation-dependent protein binding, platelet-derived growth factor receptor binding, protein binding, protein kinase activity, protein tyrosine kinase activity, protein-containing complex binding, scaffold protein binding, signaling receptor activator activity, signaling receptor binding, transferase activity, transmembrane transporter binding, ubiquitin protein ligase binding; CC: Golgi apparatus, adherens junction, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endocytic vesicle membrane, extracellular exosome, glutamatergic synapse, integrin alpha2-beta1 complex, lysosomal membrane, lysosome, membrane, membrane raft, mitochondrial crista, mitochondrial membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynaptic specialization, intracellular component, protein-containing complex
Pathways: Alpha-synuclein signaling, B Cell Receptor Signaling Pathway, B cell receptor signaling pathway - Homo sapiens (human), BCR, BCR signaling pathway, CXCR4-mediated signaling events, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Class I PI3K signaling events, EGFR1, EPHA forward signaling, EPO signaling pathway, Ephrin B reverse signaling, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fc-epsilon receptor I signaling in mast cells, GMCSF-mediated signaling events, Glypican 1 network, IL-3 signaling pathway, IL-5 signaling pathway, IL2, IL3, IL5, IL5-mediated signaling events, IL6, IL8- and CXCR1-mediated signaling events, IL8- and CXCR2-mediated signaling events, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Kit receptor signaling pathway, KitReceptor, LPA receptor mediated events, Lipid and atherosclerosis - Homo sapiens (human), Long-term depression - Homo sapiens (human), Microglia Pathogen Phagocytosis Pathway, NF-kappa B signaling pathway - Homo sapiens (human), PDGFR-beta signaling pathway, Platelet activation - Homo sapiens (human), RANKL-RANK signaling pathway, Regulation of p38-alpha and p38-beta, Signaling events mediated by PTP1B, Signaling events mediated by Stem cell factor receptor (c-Kit), TCR, Thromboxane A2 receptor signaling, Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, Viral carcinogenesis - Homo sapiens (human), bcr signaling pathway, fc epsilon receptor i signaling in mast cells, phosphoinositides and their downstream targets
UniProt: P07948
Entrez ID: 4067
|
Does Activation of ASNSD1 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
ASNSD1
|
protein/peptide accumulation
|
T cell
|
Gene: ASNSD1 (asparagine synthetase domain containing 1)
Type: protein-coding
Summary: Predicted to enable asparagine synthase (glutamine-hydrolyzing) activity. Predicted to be involved in asparagine biosynthetic process and glutamine metabolic process. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: adipose tissue development, amino acid biosynthetic process, asparagine biosynthetic process, biological_process, muscle organ development, skeletal muscle organ development, skeletal muscle tissue development, transdifferentiation; MF: asparagine synthase (glutamine-hydrolyzing) activity, molecular_function
Pathways:
UniProt: Q9NWL6
Entrez ID: 54529
|
Does Knockout of BET1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
BET1
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: BET1 (Bet1 golgi vesicular membrane trafficking protein)
Type: protein-coding
Summary: This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide-sensitive factor attachment protein receptor and may be involved in the docking of ER-derived vesicles with the cis-Golgi membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, protein binding; CC: Golgi apparatus, Golgi membrane, SNARE complex, cis-Golgi network, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O15155
Entrez ID: 10282
|
Does Knockout of CTSC in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
CTSC
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CTSC (cathepsin C)
Type: protein-coding
Summary: This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: T cell mediated cytotoxicity, apoptotic process, immune response, negative regulation of myelination, positive regulation of apoptotic signaling pathway, positive regulation of microglial cell activation, positive regulation of proteolysis involved in protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: chloride ion binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, dipeptidyl-peptidase activity, hydrolase activity, identical protein binding, peptidase activator activity involved in apoptotic process, peptidase activity, phosphatase binding, protein binding, protein-folding chaperone binding, serine-type endopeptidase activity; CC: COPII-coated ER to Golgi transport vesicle, azurophil granule lumen, centrosome, cytoplasm, endoplasmic reticulum lumen, endoplasmic reticulum-Golgi intermediate compartment membrane, extracellular exosome, extracellular matrix, extracellular region, extracellular space, lysosome, membrane, nucleoplasm
Pathways: Adaptive Immune System, Apoptosis - Homo sapiens (human), Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, ER to Golgi Anterograde Transport, Immune System, Innate Immune System, Lysosome - Homo sapiens (human), MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P53634
Entrez ID: 1075
|
Does Knockout of ADIPOR1 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
ADIPOR1
|
response to virus
|
Lung Cancer Cell Line
|
Gene: ADIPOR1 (adiponectin receptor 1)
Type: protein-coding
Summary: This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: adiponectin-activated signaling pathway, fatty acid metabolic process, fatty acid oxidation, glucose homeostasis, hormone-mediated signaling pathway, leptin-mediated signaling pathway, lipid metabolic process, negative regulation of cell growth, negative regulation of epithelial cell migration, negative regulation of epithelial to mesenchymal transition, negative regulation of non-canonical NF-kappaB signal transduction, negative regulation of receptor signaling pathway via JAK-STAT, positive regulation of cold-induced thermogenesis, positive regulation of insulin receptor signaling pathway, positive regulation of receptor signaling pathway via JAK-STAT, regulation of glucose metabolic process, regulation of lipid metabolic process; MF: adipokinetic hormone receptor activity, adiponectin binding, identical protein binding, metal ion binding, protein binding, protein kinase binding, signaling receptor activity; CC: membrane, plasma membrane
Pathways: AMP-activated protein kinase (AMPK) signaling, AMPK inhibits chREBP transcriptional activation activity, AMPK signaling pathway - Homo sapiens (human), Adipocytokine signaling pathway - Homo sapiens (human), Integration of energy metabolism, Leptin and adiponectin, Longevity regulating pathway - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease
UniProt: Q96A54
Entrez ID: 51094
|
Does Knockout of TPSAB1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
TPSAB1
|
response to virus
|
Hepatoma Cell Line
|
Gene: TPSAB1 (tryptase alpha/beta 1)
Type: protein-coding
Summary: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: defense response, extracellular matrix disassembly, proteolysis; MF: hydrolase activity, identical protein binding, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, Influenza A - Homo sapiens (human)
UniProt: Q15661
Entrez ID: 7177
|
Does Knockout of NEURL2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
NEURL2
|
cell proliferation
|
Cancer Cell Line
|
Gene: NEURL2 (neuralized E3 ubiquitin protein ligase 2)
Type: protein-coding
Summary: This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: intracellular signal transduction, protein ubiquitination; CC: cytoplasm, cytosol
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9BR09
Entrez ID: 140825
|
Does Knockout of GPR183 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
GPR183
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: GPR183 (G protein-coupled receptor 183)
Type: protein-coding
Summary: This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell activation involved in immune response, G protein-coupled receptor signaling pathway, T cell chemotaxis, T follicular helper cell differentiation, adaptive immune response, cell chemotaxis, dendritic cell chemotaxis, dendritic cell homeostasis, humoral immune response, immune response, immune system process, leukocyte chemotaxis, mature B cell differentiation involved in immune response, osteoclast differentiation, positive regulation of B cell proliferation, positive regulation of ERK1 and ERK2 cascade, regulation of astrocyte chemotaxis, signal transduction; MF: G protein-coupled receptor activity, oxysterol binding; CC: membrane, nucleoplasm, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Other, Signal Transduction, Signaling by GPCR
UniProt: P32249
Entrez ID: 1880
|
Does Knockout of MED4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
MED4
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: MED4 (mediator complex subunit 4)
Type: protein-coding
Summary: This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, protein binding, transcription coactivator activity, transcription coregulator activity; CC: core mediator complex, mediator complex, membrane, nucleoplasm, nucleus
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Thyroid hormone signaling pathway - Homo sapiens (human), Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9NPJ6
Entrez ID: 29079
|
Does Knockout of RPL36AL in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
RPL36AL
|
cell proliferation
|
T-lymphoma cell line
|
Gene: RPL36AL (ribosomal protein L36a like)
Type: protein-coding
Summary: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. This gene and the human gene officially named ribosomal protein L36a (RPL36A) encode nearly identical proteins; however, they are distinct genes. Although the name of this gene has been referred to as ribosomal protein L36a (RPL36A), its official name is ribosomal protein L36a-like (RPL36AL). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, endoplasmic reticulum, nucleus, plasma membrane, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q969Q0
Entrez ID: 6166
|
Does Knockout of COG4 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
COG4
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: COG4 (component of oligomeric golgi complex 4)
Type: protein-coding
Summary: The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010].
Gene Ontology: BP: Golgi organization, glycosylation, protein transport, retrograde transport, vesicle recycling within Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; MF: identical protein binding, protein binding; CC: Golgi apparatus, Golgi membrane, Golgi transport complex, cytoplasm, cytosol, membrane, trans-Golgi network membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9H9E3
Entrez ID: 25839
|
Does Knockout of SLF1 in Prostate Cancer Cell Line causally result in response to chemicals?
| 1
| 2,109
|
Knockout
|
SLF1
|
response to chemicals
|
Prostate Cancer Cell Line
|
Gene: SLF1 (SMC5/6 complex localization factor 1)
Type: protein-coding
Summary: Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization to site of double-strand break. Located in nucleoplasm and site of double-strand break. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, chromatin looping, double-strand break repair via homologous recombination, positive regulation of double-strand break repair, positive regulation of maintenance of mitotic sister chromatid cohesion, positive regulation of protein-containing complex assembly, protein localization to site of double-strand break, protein sumoylation, regulation of telomere maintenance; MF: protein binding, protein-containing complex binding, ubiquitin protein ligase binding; CC: Smc5-Smc6 complex, centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytoskeleton, nuclear inclusion body, nucleoplasm, nucleosome, nucleus, site of double-strand break
Pathways:
UniProt: Q9BQI6
Entrez ID: 84250
|
Does Knockout of MARVELD3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
MARVELD3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MARVELD3 (MARVEL domain containing 3)
Type: protein-coding
Summary: Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in bicellular tight junction assembly. Acts upstream of or within several processes, including negative regulation of JNK cascade; negative regulation of epithelial cell migration; and negative regulation of epithelial cell proliferation. Located in bicellular tight junction and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: bicellular tight junction assembly, cell-cell junction organization, negative regulation of JNK cascade, negative regulation of epithelial cell migration, negative regulation of epithelial cell proliferation, protein localization to cell junction, response to osmotic stress; MF: mitogen-activated protein kinase kinase kinase binding, protein binding; CC: anchoring junction, bicellular tight junction, cytoplasmic vesicle, membrane
Pathways: Tight junction - Homo sapiens (human)
UniProt: Q96A59
Entrez ID: 91862
|
Does Knockout of PRR23A in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
PRR23A
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: PRR23A (proline rich 23A)
Type: protein-coding
Summary: proline rich 23A
Gene Ontology:
Pathways:
UniProt: A6NEV1
Entrez ID: 729627
|
Does Knockout of ACTR2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
ACTR2
|
cell proliferation
|
Cancer Cell Line
|
Gene: ACTR2 (actin related protein 2)
Type: protein-coding
Summary: The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin cytoskeleton organization, asymmetric cell division, cellular response to type II interferon, cilium assembly, cytosolic transport, establishment or maintenance of cell polarity, meiotic cell cycle, meiotic chromosome movement towards spindle pole, meiotic cytokinesis, positive regulation of double-strand break repair via homologous recombination, positive regulation of lamellipodium assembly, positive regulation of transcription by RNA polymerase II, regulation of double-strand break repair via nonhomologous end joining, spindle localization; MF: ATP binding, actin binding, actin filament binding, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, actin cap, actin cytoskeleton, azurophil granule lumen, cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, focal adhesion, membrane, nucleus, site of double-strand break
Pathways: Association Between Physico-Chemical Features and Toxicity Associated Pathways, Axon guidance, Bacterial invasion of epithelial cells - Homo sapiens (human), CDC42 signaling events, Clathrin-mediated endocytosis, Developmental Biology, Disease, EGFR1, EPH-Ephrin signaling, EPHB-mediated forward signaling, ESC Pluripotency Pathways, Endocytosis - Homo sapiens (human), ErbB1 downstream signaling, FCGR3A-mediated phagocytosis, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania phagocytosis, Membrane Trafficking, Nervous system development, Neutrophil degranulation, PDGFR-beta signaling pathway, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), RAC1 signaling pathway, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Homo sapiens (human), Vesicle-mediated transport, Yersinia infection - Homo sapiens (human), how does salmonella hijack a cell, role of pi3k subunit p85 in regulation of actin organization and cell migration, y branching of actin filaments
UniProt: P61160
Entrez ID: 10097
|
Does Knockout of PSMD2 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 1
| 1,480
|
Knockout
|
PSMD2
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of protein catabolic process; MF: enzyme regulator activity, protein binding; CC: cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, base subcomplex, proteasome storage granule, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNF-alpha signaling pathway, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q13200
Entrez ID: 5708
|
Does Knockout of BHLHE41 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
BHLHE41
|
response to virus
|
Hepatoma Cell Line
|
Gene: BHLHE41 (basic helix-loop-helix family member e41)
Type: protein-coding
Summary: This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: anterior/posterior pattern specification, circadian regulation of gene expression, circadian rhythm, negative regulation of DNA-templated transcription, negative regulation of myotube differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription by competitive promoter binding, regulation of DNA-templated transcription, regulation of neurogenesis, regulation of transcription by RNA polymerase II, rhythmic process; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, MRF binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, bHLH transcription factor binding, histone deacetylase binding, protein binding, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways: BMAL1:CLOCK,NPAS2 activates circadian expression, Circadian clock, Circadian rhythm - Homo sapiens (human), HIF-1-alpha transcription factor network, Pathways in clear cell renal cell carcinoma
UniProt: Q9C0J9
Entrez ID: 79365
|
Does Knockout of TOP1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
TOP1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: TOP1 (DNA topoisomerase I)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, DNA topological change, animal organ regeneration, cellular response to luteinizing hormone stimulus, chromatin remodeling, chromosome segregation, circadian regulation of gene expression, circadian rhythm, embryonic cleavage, peptidyl-serine phosphorylation, programmed cell death, rRNA transcription, response to cAMP, response to gamma radiation, response to temperature stimulus, response to xenobiotic stimulus, rhythmic process; MF: ATP binding, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, double-stranded DNA binding, isomerase activity, protein binding, protein domain specific binding, protein serine/threonine kinase activity, protein-containing complex binding, single-stranded DNA binding, supercoiled DNA binding; CC: P-body, chromosome, cytoplasm, dense fibrillar component, fibrillar center, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, perikaryon, protein-DNA complex
Pathways: AndrogenReceptor, Caspase Cascade in Apoptosis, Ebola Virus Pathway on Host, Irinotecan Action Pathway, Irinotecan Metabolism Pathway, Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins
UniProt: P11387
Entrez ID: 7150
|
Does Knockout of COPA in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
COPA
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: COPA (coat protein complex I subunit alpha)
Type: protein-coding
Summary: In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, pancreatic juice secretion, protein localization to axon, protein localization to cell leading edge, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, signal transduction, vesicle-mediated transport; MF: hormone activity, mRNA binding, protein binding, structural molecule activity; CC: COPI vesicle coat, COPI-coated vesicle, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum membrane, extracellular exosome, extracellular region, extracellular space, growth cone, membrane, membrane coat, transport vesicle
Pathways: Arf1 pathway, Asparagine N-linked glycosylation, C-MYB transcription factor network, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, adp-ribosylation factor
UniProt: P53621
Entrez ID: 1314
|
Does Knockout of DRD1 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
DRD1
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: DRD1 (dopamine receptor D1)
Type: protein-coding
Summary: This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: D-glucose import, G protein-coupled dopamine receptor signaling pathway, G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-activating dopamine receptor signaling pathway, adult walking behavior, associative learning, astrocyte development, behavioral fear response, behavioral response to cocaine, cell migration, cellular response to catecholamine stimulus, cerebral cortex GABAergic interneuron migration, conditioned taste aversion, dentate gyrus development, dopamine metabolic process, dopamine transport, feeding behavior, grooming behavior, habituation, hippocampus development, learning, locomotory behavior, long-term synaptic depression, long-term synaptic potentiation, maternal behavior, mating behavior, memory, modification of postsynaptic structure, muscle contraction, neuron migration, neuronal action potential, operant conditioning, peristalsis, phospholipase C-activating dopamine receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of cell migration, positive regulation of neuron migration, positive regulation of potassium ion transport, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of synaptic transmission, glutamatergic, prepulse inhibition, presynaptic modulation of chemical synaptic transmission, protein import into nucleus, regulation of dopamine metabolic process, regulation of dopamine uptake involved in synaptic transmission, response to amphetamine, response to cocaine, response to xenobiotic stimulus, sensitization, signal transduction, striatum development, synapse assembly, synaptic transmission, dopaminergic, synaptic transmission, glutamatergic, temperature homeostasis, transmission of nerve impulse, vasodilation, visual learning; MF: G protein-coupled receptor activity, G-protein alpha-subunit binding, arrestin family protein binding, dopamine binding, dopamine neurotransmitter receptor activity, dopamine neurotransmitter receptor activity, coupled via Gs, heterotrimeric G-protein binding, protein binding; CC: G protein-coupled receptor complex, GABA-ergic synapse, cell projection, ciliary membrane, cilium, dendrite, dendritic spine, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, glutamatergic synapse, membrane, non-motile cilium, nucleus, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse
Pathways: 3-Methylthiofentanyl Action Pathway, Alcoholism - Homo sapiens (human), Alfentanil Action Pathway, Alvimopan Action Pathway, Amine ligand-binding receptors, Amphetamine addiction - Homo sapiens (human), Anileridine Action Pathway, Benzocaine Action Pathway, Bupivacaine Action Pathway, Buprenorphine Action Pathway, Calcium signaling pathway - Homo sapiens (human), Carfentanil Action Pathway, Chloroprocaine Action Pathway, Citalopram Action Pathway, Class A/1 (Rhodopsin-like receptors), Cocaine Action Pathway, Cocaine addiction - Homo sapiens (human), Codeine Action Pathway, Common Pathways Underlying Drug Addiction, Desipramine Action Pathway, Dezocine Action Pathway, Dibucaine Action Pathway, Dihydromorphine Action Pathway, Dimethylthiambutene Action Pathway, Diphenoxylate Action Pathway, Dopamine Activation of Neurological Reward System, Dopamine receptors, Dopaminergic synapse - Homo sapiens (human), Escitalopram Action Pathway, Ethylmorphine Action Pathway, Fentanyl Action Pathway, Fluoxetine Action Pathway, G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Gap junction - Homo sapiens (human), Ghrelin, Heroin Action Pathway, Hydrocodone Action Pathway, Hydromorphone Action Pathway, Imipramine Action Pathway, Ketobemidone Action Pathway, Levallorphan Action Pathway, Levobupivacaine Action Pathway, Levomethadyl Acetate Action Action Pathway, Levorphanol Action Pathway, Lidocaine (Local Anaesthetic) Action Pathway, Mepivacaine Action Pathway, Methadone Action Pathway, Methadyl Acetate Action Pathway, Monoamine GPCRs, Morphine Action Pathway, Morphine addiction - Homo sapiens (human), Nalbuphine Action Pathway, Naloxone Action Pathway, Naltrexone Action Pathway, Neuroactive ligand-receptor interaction - Homo sapiens (human), Nicotine Action Pathway, Oxybuprocaine Action Pathway, Oxycodone Action Pathway, Oxymorphone Action Pathway, Parkinson disease - Homo sapiens (human), Pentazocine Action Pathway, Phosphodiesterases in neuronal function, Prilocaine Action Pathway, Procaine Action Pathway, Proparacaine Action Pathway, Propoxyphene Action Pathway, Remifentanil Action Pathway, Ropivacaine Action Pathway, Signal Transduction, Signaling by GPCR, Sufentanil Action Pathway, Tramadol Action Action Pathway, cAMP signaling pathway - Homo sapiens (human), regulation of ck1/cdk5 by type 1 glutamate receptors
UniProt: P21728
Entrez ID: 1812
|
Does Knockout of PPP2CA in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
PPP2CA
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PPP2CA (protein phosphatase 2 catalytic subunit alpha)
Type: protein-coding
Summary: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, T cell homeostasis, intracellular signal transduction, meiotic cell cycle, mesoderm development, mitotic cell cycle, negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial to mesenchymal transition, negative regulation of glycolytic process through fructose-6-phosphate, negative regulation of hippo signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, peptidyl-threonine dephosphorylation, positive regulation of NLRP3 inflammasome complex assembly, protein dephosphorylation, regulation of G1/S transition of mitotic cell cycle, regulation of cell differentiation, regulation of growth, regulation of microtubule polymerization, regulation of transcription by RNA polymerase II, response to lead ion, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, vascular endothelial cell response to oscillatory fluid shear stress; MF: GABA receptor binding, RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein heterodimerization activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, tau protein binding; CC: FAR/SIN/STRIPAK complex, INTAC complex, chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, extracellular exosome, membrane, membrane raft, microtubule cytoskeleton, mitochondrion, nucleus, plasma membrane, protein phosphatase type 2A complex, protein serine/threonine phosphatase complex, spindle pole, synapse
Pathways: 16p11.2 proximal deletion syndrome, AMPK signaling pathway - Homo sapiens (human), ATR signaling pathway, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Association Between Physico-Chemical Features and Toxicity Associated Pathways, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), Brain-derived neurotrophic factor (BDNF) signaling pathway, C-MYC pathway, Cancer immunotherapy by CTLA4 blockade, Chagas disease - Homo sapiens (human), Dopamine metabolism, Dopaminergic synapse - Homo sapiens (human), ErbB1 downstream signaling, FGFR3 signaling in chondrocyte proliferation and terminal differentiation, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glycogen Synthesis and Degradation, Hepatitis C - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IL3, IL8- and CXCR2-mediated signaling events, Long-term depression - Homo sapiens (human), Mesodermal commitment pathway, Oocyte meiosis - Homo sapiens (human), PDGFR-beta signaling pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PLK1 signaling events, Regulation of retinoblastoma protein, Sphingolipid pathway, Sphingolipid signaling pathway - Homo sapiens (human), TGF-beta receptor signaling, TGF-beta signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, Tight junction - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, Wnt, Wnt signaling pathway and pluripotency, akt signaling pathway, mRNA surveillance pathway - Homo sapiens (human), p53 pathway, regulation of eif-4e and p70s6 kinase
UniProt: P67775
Entrez ID: 5515
|
Does Knockout of CCL25 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
CCL25
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: CCL25 (C-C motif chemokine ligand 25)
Type: protein-coding
Summary: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, antimicrobial humoral immune response mediated by antimicrobial peptide, cell chemotaxis, cell surface receptor signaling pathway, chemokine-mediated signaling pathway, chemotaxis, eosinophil chemotaxis, immune response, immune system process, inflammatory response, killing of cells of another organism, negative regulation of leukocyte tethering or rolling, positive regulation of cell migration, positive regulation of cell-matrix adhesion; MF: CCR chemokine receptor binding, CCR10 chemokine receptor binding, chemokine activity, chemokine receptor binding, cytokine activity, hormone activity, protein binding; CC: extracellular region, extracellular space
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Homo sapiens (human), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Intestinal immune network for IgA production - Homo sapiens (human), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: O15444
Entrez ID: 6370
|
Does Knockout of TUBGCP5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
TUBGCP5
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TUBGCP5 (tubulin gamma complex component 5)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, spindle assembly; MF: gamma-tubulin binding, microtubule binding, microtubule minus-end binding, protein binding; CC: centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, gamma-tubulin complex, gamma-tubulin ring complex, microtubule, microtubule organizing center, spindle pole
Pathways: 15q11.2 copy number variation syndrome, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Prader-Willi and Angelman Syndrome, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes
UniProt: Q96RT8
Entrez ID: 114791
|
Does Knockout of POTEG in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
POTEG
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: POTEG (POTE ankyrin domain family member G)
Type: protein-coding
Summary: POTE ankyrin domain family member G
Gene Ontology:
Pathways:
UniProt: Q6S5H5
Entrez ID: 404785
|
Does Knockout of PRR18 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
PRR18
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: PRR18 (proline rich 18)
Type: protein-coding
Summary: proline rich 18
Gene Ontology:
Pathways:
UniProt: Q8N4B5
Entrez ID: 285800
|
Does Knockout of ATG14 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
ATG14
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: ATG14 (autophagy related 14)
Type: protein-coding
Summary: Enables GTPase binding activity. Involved in several processes, including macroautophagy; regulation of phosphorylation; and response to mitochondrial depolarisation. Acts upstream of or within endosome to lysosome transport. Located in autophagosome and phagophore assembly site membrane. Is extrinsic component of omegasome membrane and extrinsic component of phagophore assembly site membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagosome assembly, autophagosome maturation, autophagosome membrane docking, autophagy, cellular response to glucose starvation, cellular response to starvation, defense response to virus, early endosome to late endosome transport, endosome to lysosome transport, innate immune response, macroautophagy, mitophagy, negative regulation of protein phosphorylation, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol-3-phosphate biosynthetic process, positive regulation of protein phosphorylation, post-transcriptional regulation of gene expression, protein targeting to lysosome, regulation of macroautophagy, regulation of protein complex stability, regulation of triglyceride metabolic process, response to mitochondrial depolarisation; MF: GTPase binding, phosphatidylinositol 3-kinase inhibitor activity, phosphatidylinositol 3-kinase regulator activity, protein binding, protein-membrane adaptor activity; CC: autophagosome, autophagosome membrane, axoneme, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extrinsic component of omegasome membrane, extrinsic component of phagophore assembly site membrane, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, phagocytic vesicle, phagophore assembly site, phagophore assembly site membrane, phosphatidylinositol 3-kinase complex, class III, protein-containing complex
Pathways: Adaptive Immune System, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Autophagy, Autophagy - animal - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, Disease, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Macroautophagy, Nanoparticle triggered autophagic cell death, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Senescence and Autophagy in Cancer, Shigellosis - Homo sapiens (human), Spinocerebellar ataxia - Homo sapiens (human), Viral Infection Pathways
UniProt: Q6ZNE5
Entrez ID: 22863
|
Does Activation of NRCAM in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
NRCAM
|
response to virus
|
Hepatoma Cell Line
|
Gene: NRCAM (neuronal cell adhesion molecule)
Type: protein-coding
Summary: Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: angiogenesis, axon guidance, axonal fasciculation, axonogenesis, brain development, cell adhesion, cell-cell adhesion, central nervous system development, clustering of voltage-gated sodium channels, heterotypic cell-cell adhesion, intracellular protein localization, neuron migration, neuronal action potential propagation, positive regulation of neuron differentiation, regulation of axon extension, regulation of neuron projection development, regulation of postsynapse organization, retinal ganglion cell axon guidance, synapse assembly, synapse organization; MF: ankyrin binding, cell-cell adhesion mediator activity, protein binding, protein binding involved in heterotypic cell-cell adhesion; CC: axon, axon initial segment, cell projection, external side of plasma membrane, extracellular region, glutamatergic synapse, membrane, neuron projection, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse
Pathways: Axon guidance, Cell adhesion molecules - Homo sapiens (human), Developmental Biology, Interaction between L1 and Ankyrins, L1CAM interactions, Nervous system development, Neurofascin interactions, NrCAM interactions
UniProt: Q92823
Entrez ID: 4897
|
Does Knockout of ZBP1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
ZBP1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ZBP1 (Z-DNA binding protein 1)
Type: protein-coding
Summary: This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: activation of innate immune response, antiviral innate immune response, apoptotic process, defense response to fungus, defense response to virus, execution phase of necroptosis, immune system process, innate immune response, necroptotic signaling pathway, positive regulation of apoptotic process, positive regulation of inflammatory response, positive regulation of necroptotic process, positive regulation of type I interferon-mediated signaling pathway, programmed cell death, pyroptotic inflammatory response, regulation of inflammatory response, regulation of interleukin-1-mediated signaling pathway; MF: DNA binding, RNA binding, double-stranded RNA adenosine deaminase activity, double-stranded RNA binding, identical protein binding, left-handed Z-DNA binding, protein binding; CC: cytoplasm, cytosol, nucleus
Pathways: Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , Disease, IRF3 mediated activation of type 1 IFN, Immune System, Infectious disease, Innate Immune System, Necroptosis - Homo sapiens (human), Potential therapeutics for SARS, RIP-mediated NFkB activation via ZBP1, Regulation of innate immune responses to cytosolic DNA, SARS-CoV Infections, Viral Infection Pathways, ZBP1(DAI) mediated induction of type I IFNs
UniProt: Q9H171
Entrez ID: 81030
|
Does Knockout of SEC31B in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
SEC31B
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: SEC31B (SEC31 homolog B, COPII component)
Type: protein-coding
Summary: This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: COPII-coated vesicle cargo loading, endoplasmic reticulum organization, endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle-mediated transport; CC: COPII vesicle coat, ER to Golgi transport vesicle membrane, cytoplasm, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, membrane, vesicle coat
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Sterol regulatory element-binding proteins (SREBP) signaling, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9NQW1
Entrez ID: 25956
|
Does Knockout of CFAP20 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
CFAP20
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CFAP20 (cilia and flagella associated protein 20)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in several processes, including positive regulation of feeding behavior; protein polyglutamylation; and regulation of cell motility. Located in centriole; ciliary basal body; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cilium assembly, flagellated sperm motility, positive regulation of cell motility, positive regulation of feeding behavior, protein polyglutamylation, regulation of cilium beat frequency involved in ciliary motility; MF: RNA binding, protein binding; CC: axonemal B tubule inner sheath, axonemal microtubule, cell projection, centriole, ciliary basal body, cilium, cytoplasm, cytoskeleton, extracellular exosome, microtubule, motile cilium, nucleoplasm, nucleus, sperm flagellum
Pathways:
UniProt: Q9Y6A4
Entrez ID: 29105
|
Does Knockout of NEMP2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
NEMP2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: NEMP2 (nuclear envelope integral membrane protein 2)
Type: protein-coding
Summary: Predicted to be located in nuclear inner membrane. Predicted to be integral component of membrane. Predicted to be active in nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, nuclear envelope, nuclear inner membrane, nucleus
Pathways:
UniProt: A6NFY4
Entrez ID: 100131211
|
Does Knockout of NEK8 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
NEK8
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: NEK8 (NIMA related kinase 8)
Type: protein-coding
Summary: This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: animal organ development, animal organ morphogenesis, determination of left/right symmetry, heart development, regulation of hippo signaling; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cell projection, centrosome, ciliary base, ciliary inversin compartment, cilium, cytoplasm, cytoskeleton
Pathways: Ciliary landscape, Ciliopathies, Joubert Syndrome
UniProt: Q86SG6
Entrez ID: 284086
|
Does Knockout of GADD45B in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
GADD45B
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GADD45B (growth arrest and DNA damage inducible beta)
Type: protein-coding
Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, cell differentiation, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of apoptotic process, positive regulation of p38MAPK cascade, regulation of cell cycle; CC: cytoplasm, nucleus
Pathways: Adipogenesis, Apoptosis - Homo sapiens (human), Basal cell carcinoma - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, Cell cycle, Cell cycle - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Chromosomal and microsatellite instability in colorectal cancer, Chronic myeloid leukemia - Homo sapiens (human), Colorectal cancer - Homo sapiens (human), DNA damage response, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), FoxO signaling pathway - Homo sapiens (human), Gastric cancer - Homo sapiens (human), Glioma - Homo sapiens (human), Glucocorticoid Receptor Pathway, Hepatocellular carcinoma - Homo sapiens (human), IL12-mediated signaling events, MAPK signaling pathway - Homo sapiens (human), Melanoma, Melanoma - Homo sapiens (human), NF-kappa B signaling pathway - Homo sapiens (human), Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Nuclear Receptors Meta-Pathway, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Thyroid cancer - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), miRNA regulation of DNA damage response, p38 MAPK signaling pathway, p53 signaling pathway - Homo sapiens (human)
UniProt: O75293
Entrez ID: 4616
|
Does Knockout of DDX23 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
DDX23
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: DDX23 (DEAD-box helicase 23)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: R-loop processing, RNA splicing, RNA splicing, via transesterification reactions, cis assembly of pre-catalytic spliceosome, mRNA processing, mRNA splicing, via spliceosome; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding; CC: U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, chromatin, chromosome, extracellular exosome, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q9BUQ8
Entrez ID: 9416
|
Does Knockout of DPY19L2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
DPY19L2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DPY19L2 (dpy-19 like 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011].
Gene Ontology: BP: cell differentiation, spermatid development, spermatogenesis; MF: glycosyltransferase activity, mannosyltransferase activity, transferase activity; CC: membrane, nuclear inner membrane, nucleus
Pathways:
UniProt: Q6NUT2
Entrez ID: 283417
|
Does Knockout of DNA2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
DNA2
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: DNA2 (DNA replication helicase/nuclease 2)
Type: protein-coding
Summary: This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA geometric change, DNA repair, DNA replication, DNA replication checkpoint signaling, DNA replication, Okazaki fragment processing, DNA replication, removal of RNA primer, base-excision repair, mitochondrial DNA repair, mitochondrial DNA replication, mitotic telomere maintenance via semi-conservative replication, positive regulation of DNA replication, replication fork reversal, t-circle formation, telomere maintenance, telomere maintenance via semi-conservative replication; MF: 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, 5'-flap endonuclease activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, RNA binding, catalytic activity, deoxyribonuclease (pyrimidine dimer) activity, endonuclease activity, helicase activity, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nuclease activity, nucleotide binding, protein binding, single-stranded DNA helicase activity; CC: chromosome, telomeric region, cytoplasm, gamma DNA polymerase complex, mitochondrial nucleoid, mitochondrion, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Defective homologous recombination repair (HRR) due to BRCA1 loss of function, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Defective homologous recombination repair (HRR) due to PALB2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Extension of Telomeres, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Impaired BRCA2 binding to PALB2, Impaired BRCA2 binding to RAD51, Lagging Strand Synthesis, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Transcriptional Regulation by TP53
UniProt: P51530
Entrez ID: 1763
|
Does Inhibition of SF3B3 in Gastric tumor organoid model causally result in response to chemicals?
| 0
| 2,482
|
Inhibition
|
SF3B3
|
response to chemicals
|
Gastric tumor organoid model
|
Gene: SF3B3 (splicing factor 3b subunit 3)
Type: protein-coding
Summary: This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, negative regulation of protein catabolic process, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing; MF: U2 snRNA binding, nucleic acid binding, protein binding, protein-containing complex binding; CC: SAGA complex, U12-type spliceosomal complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q15393
Entrez ID: 23450
|
Does Knockout of MED11 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
MED11
|
cell proliferation
|
Cancer Cell Line
|
Gene: MED11 (mediator complex subunit 11)
Type: protein-coding
Summary: MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II; MF: protein binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Infectious disease, Metabolism, Metabolism of lipids, PPARA activates gene expression, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9P086
Entrez ID: 400569
|
Does Knockout of CDC7 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
CDC7
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: CDC7 (cell division cycle 7)
Type: protein-coding
Summary: This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell cycle phase transition, cell division, double-strand break repair via break-induced replication, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of nuclear cell cycle DNA replication, signal transduction; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, intercellular bridge, mitotic spindle, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G2/M Checkpoints, Gene expression (Transcription), Generic Transcription Pathway, Mitotic G1 phase and G1/S transition, RNA Polymerase II Transcription, Retinoblastoma gene in cancer, Transcriptional Regulation by E2F6
UniProt: O00311
Entrez ID: 8317
|
Does Knockout of GGN in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
GGN
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: GGN (gametogenetin)
Type: protein-coding
Summary: This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, double-strand break repair, gamete generation, spermatogenesis; MF: protein binding, ubiquitin protein ligase binding
Pathways:
UniProt: Q86UU5
Entrez ID: 199720
|
Does Knockout of VEGFB in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
VEGFB
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: VEGFB (vascular endothelial growth factor B)
Type: protein-coding
Summary: This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: cardiac muscle contraction, coronary vasculature development, heart development, induction of positive chemotaxis, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of neuron apoptotic process, positive chemotaxis, positive regulation of ERK1 and ERK2 cascade, positive regulation of cell division, positive regulation of cell population proliferation, positive regulation of endothelial cell proliferation, positive regulation of mast cell chemotaxis, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of vascular permeability, positive regulation of vascular wound healing, protein O-linked glycosylation, response to hypoxia, sprouting angiogenesis, vascular endothelial growth factor receptor signaling pathway, vascular endothelial growth factor signaling pathway; MF: chemoattractant activity, growth factor activity, heparin binding, identical protein binding, protein binding, receptor ligand activity, vascular endothelial growth factor receptor 1 binding, vascular endothelial growth factor receptor binding; CC: extracellular region, extracellular space, membrane, platelet alpha granule lumen
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Calcium signaling pathway - Homo sapiens (human), Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Heart Development, Hemostasis, MAPK signaling pathway - Homo sapiens (human), MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Platelet activation, signaling and aggregation, Platelet degranulation , Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Response to elevated platelet cytosolic Ca2+, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, VEGF and VEGFR signaling network, VEGF binds to VEGFR leading to receptor dimerization, VEGF ligand-receptor interactions, VEGFR1 specific signals
UniProt: P49765
Entrez ID: 7423
|
Does Knockout of PGAM1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
PGAM1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PGAM1 (phosphoglycerate mutase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: canonical glycolysis, gluconeogenesis, glycolytic process; MF: bisphosphoglycerate mutase activity, catalytic activity, hydrolase activity, intramolecular phosphotransferase activity, isomerase activity, phosphoglycerate mutase activity, protein binding, protein kinase binding; CC: cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, secretory granule lumen
Pathways: Central carbon metabolism in cancer - Homo sapiens (human), Cori Cycle, EGFR1, Fanconi-bickel syndrome, Fructose-1,6-diphosphatase deficiency, Glucagon signaling pathway - Homo sapiens (human), Gluconeogenesis, Glucose metabolism, Glycine, serine and threonine metabolism - Homo sapiens (human), Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycogenosis, Type VII. Tarui disease, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, Immune System, Innate Immune System, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Rapoport-Luebering glycolytic shunt, TCR, Triosephosphate isomerase, gluconeogenesis, glycolysis, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P18669
Entrez ID: 5223
|
Does Knockout of RND1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
RND1
|
cell proliferation
|
Cancer Cell Line
|
Gene: RND1 (Rho family GTPase 1)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: actin filament organization, negative regulation of cell adhesion, neuron remodeling, regulation of actin cytoskeleton organization, signal transduction, small GTPase-mediated signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding, protein kinase binding, signaling receptor binding; CC: actin cytoskeleton, adherens junction, cytoplasm, cytoskeleton, cytosol, membrane, plasma membrane
Pathways: Axon guidance, Axon guidance - Homo sapiens (human), Developmental Biology, Nervous system development, RHO GTPase cycle, RND1 GTPase cycle, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion, Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Sema4D mediated inhibition of cell attachment and migration, Semaphorin interactions, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, VEGFA-VEGFR2 Signaling Pathway
UniProt: Q92730
Entrez ID: 27289
|
Does Knockout of THY1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
THY1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: THY1 (Thy-1 cell surface antigen)
Type: protein-coding
Summary: This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: T cell receptor signaling pathway, angiogenesis, cell adhesion, cell surface receptor signaling pathway, cell-cell adhesion, cell-cell signaling, cytoskeleton organization, focal adhesion assembly, heterotypic cell-cell adhesion, integrin-mediated signaling pathway, negative regulation of T cell receptor signaling pathway, negative regulation of axonogenesis, negative regulation of cell migration, negative regulation of neuron projection regeneration, negative regulation of protein kinase activity, positive regulation of GTPase activity, positive regulation of T cell activation, positive regulation of cell adhesion, positive regulation of cellular extravasation, positive regulation of focal adhesion assembly, positive regulation of release of sequestered calcium ion into cytosol, receptor clustering, regulation of cell migration, regulation of cell-matrix adhesion, regulation of immune system process, retinal cone cell development; MF: GPI anchor binding, GTPase activator activity, integrin binding, protein binding; CC: apical plasma membrane, axolemma, cell surface, dendrite, dendrite membrane, endoplasmic reticulum, external side of plasma membrane, extracellular exosome, extracellular region, focal adhesion, glutamatergic synapse, growth cone, membrane, membrane raft, neuronal cell body membrane, plasma membrane, postsynapse, presynapse, side of membrane
Pathways: Beta2 integrin cell surface interactions, Beta3 integrin cell surface interactions, Cardiac Progenitor Differentiation, IL4-mediated signaling events, Leukocyte transendothelial migration - Homo sapiens (human), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, amb2 Integrin signaling
UniProt: P04216
Entrez ID: 7070
|
Does Knockout of KRTDAP in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
KRTDAP
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: KRTDAP (keratinocyte differentiation associated protein)
Type: protein-coding
Summary: This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance of stratified epithelia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: cell differentiation, epidermis development; CC: extracellular region, extracellular space, lamellar body
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
UniProt: P60985
Entrez ID: 388533
|
Does Knockout of SLC35G5 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
SLC35G5
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: SLC35G5 (solute carrier family 35 member G5)
Type: protein-coding
Summary: This gene is intronless and probably arose from retrotransposition of a similar gene. It has high sequence similarity to the gene encoding acyl-malonyl condensing enzyme on chromosome 17. [provided by RefSeq, Aug 2011].
Gene Ontology: CC: membrane
Pathways:
UniProt: Q96KT7
Entrez ID: 83650
|
Does Knockout of FAM83F in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
FAM83F
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: FAM83F (family with sequence similarity 83 member F)
Type: protein-coding
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, protein kinase binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q8NEG4
Entrez ID: 113828
|
Does Knockout of RMND5A in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
RMND5A
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: RMND5A (required for meiotic nuclear division 5 homolog A)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Located in cytoplasm and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: GID complex, cytoplasm, cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Ciliary landscape, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: Q9H871
Entrez ID: 64795
|
Does Knockout of DDX59 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
DDX59
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: DDX59 (DEAD-box helicase 59)
Type: protein-coding
Summary: Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be located in cytoplasm and nucleus. Predicted to be integral component of membrane. Implicated in orofaciodigital syndrome V. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, mRNA binding, metal ion binding, nucleic acid binding, nucleotide binding, zinc ion binding; CC: cytoplasm, nucleus
Pathways: Ciliopathies
UniProt: Q5T1V6
Entrez ID: 83479
|
Does Knockout of SNHG28 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
SNHG28
|
response to virus
|
Huh-7 Cell
|
Gene: SNHG28 (small nucleolar RNA host gene 28)
Type: ncRNA
Summary: Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 284677
|
Does Knockout of DTL in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
DTL
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DTL (denticleless E3 ubiquitin protein ligase adapter)
Type: protein-coding
Summary: Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in centrosome; cytosol; and nuclear lumen. Part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA replication, mitotic G2 DNA damage checkpoint signaling, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of catabolic process, positive regulation of protein catabolic process, positive regulation of protein metabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, regulation of cell cycle, response to UV, rhythmic process, translesion synthesis, ubiquitin-dependent protein catabolic process; MF: protein binding, protein-macromolecule adaptor activity, ubiquitin-protein transferase activity; CC: Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, centrosome, chromosome, cytoplasm, cytoskeleton, cytosol, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Repair, Metabolism of proteins, Neddylation, Post-translational protein modification, Recognition of DNA damage by PCNA-containing replication complex
UniProt: Q9NZJ0
Entrez ID: 51514
|
Does Knockout of TOPBP1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
TOPBP1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TOPBP1 (DNA topoisomerase II binding protein 1)
Type: protein-coding
Summary: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA metabolic process, DNA repair, DNA replication checkpoint signaling, DNA replication initiation, broken chromosome clustering, chromatin organization, chromosome organization, double-strand break repair, double-strand break repair via alternative nonhomologous end joining, double-strand break repair via classical nonhomologous end joining, double-strand break repair via homologous recombination, homologous recombination, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, protein localization to site of double-strand break, response to ionizing radiation; MF: DNA binding, chromatin-protein adaptor activity, identical protein binding, phosphorylation-dependent protein binding, protein binding, protein serine/threonine kinase activator activity; CC: BRCA1-B complex, PML body, actin cytoskeleton, centrosome, chromosome, condensed nuclear chromosome, cytoplasm, cytoskeleton, male germ cell nucleus, nuclear body, nucleoplasm, nucleus, plasma membrane, site of DNA damage, site of double-strand break, spindle pole
Pathways: ATR Signaling, ATR signaling pathway, BARD1 signaling events, Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, E2F transcription factor network, Fanconi anemia pathway, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to RAD51, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53
UniProt: Q92547
Entrez ID: 11073
|
Does Knockout of ACVR1B in Glioma Cell Line causally result in protein/peptide accumulation?
| 0
| 589
|
Knockout
|
ACVR1B
|
protein/peptide accumulation
|
Glioma Cell Line
|
Gene: ACVR1B (activin A receptor type 1B)
Type: protein-coding
Summary: This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, activin receptor signaling pathway, cell surface receptor protein serine/threonine kinase signaling pathway, cellular response to growth factor stimulus, extrinsic apoptotic signaling pathway, hair follicle development, in utero embryonic development, negative regulation of cell differentiation, negative regulation of cell growth, negative regulation of gene expression, negative regulation of ossification, nervous system development, nodal signaling pathway, peptidyl-threonine phosphorylation, positive regulation of activin receptor signaling pathway, positive regulation of erythrocyte differentiation, positive regulation of gene expression, positive regulation of trophoblast cell migration, protein autophosphorylation, regulation of DNA-templated transcription, regulation of cell migration, regulation of gene expression, regulation of multicellular organismal process, regulation of signal transduction, signal transduction; MF: ATP binding, I-SMAD binding, SMAD binding, activin binding, activin receptor activity, activin receptor activity, type I, growth factor binding, inhibin binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity, transmembrane receptor protein serine/threonine kinase activity, ubiquitin protein ligase binding; CC: activin receptor complex, cell surface, membrane, plasma membrane, receptor complex, serine/threonine protein kinase complex
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human), Developmental Biology, Regulation of signaling by NODAL, Signal Transduction, Signaling by Activin, Signaling by NODAL, Signaling by TGFB family members, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), TGF-beta signaling pathway - Homo sapiens (human)
UniProt: P36896
Entrez ID: 91
|
Does Knockout of DNM2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
DNM2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: DNM2 (dynamin 2)
Type: protein-coding
Summary: Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, actin filament bundle organization, antigen processing and presentation of exogenous peptide antigen via MHC class II, autophagy, centrosome cycle, endocytosis, membrane organization, membrane tubulation, negative regulation of membrane tubulation, neuron projection morphogenesis, phagocytosis, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, post-Golgi vesicle-mediated transport, protein polymerization, receptor internalization, receptor-mediated endocytosis, regulation of DNA-templated transcription, regulation of axon extension, signal transduction, stress fiber assembly, synaptic vesicle budding from presynaptic endocytic zone membrane, synaptic vesicle transport, transferrin transport, vesicle scission; MF: GTP binding, GTPase activity, SH3 domain binding, enzyme binding, hydrolase activity, microtubule binding, nucleotide binding, phosphatidylinositol-4,5-bisphosphate binding, protein binding; CC: Golgi apparatus, Golgi membrane, anchoring junction, cell projection, centriole, centrosome, clathrin-coated pit, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endocytic vesicle membrane, endomembrane system, endosome, extracellular exosome, focal adhesion, growth cone, membrane, microtubule, midbody, neuron projection, phagocytic cup, phagocytic vesicle membrane, plasma membrane, podosome, postsynaptic density, postsynaptic membrane, presynapse, recycling endosome, synapse, uropod
Pathways: Arf6 trafficking events, Bacterial invasion of epithelial cells - Homo sapiens (human), Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), Endocytosis - Homo sapiens (human), Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fragile X Syndrome, IL5, Intracellular trafficking proteins involved in CMT neuropathy, PAR1-mediated thrombin signaling events, PDGFR-beta signaling pathway, Phospholipase D signaling pathway - Homo sapiens (human), Posttranslational regulation of adherens junction stability and dissassembly, Prolactin, Salmonella infection - Homo sapiens (human), Signaling events mediated by VEGFR1 and VEGFR2, Synaptic Vesicle Pathway, Synaptic vesicle cycle - Homo sapiens (human), Syndecan-4-mediated signaling events, TCR
UniProt: P50570
Entrez ID: 1785
|
Does Knockout of CXXC4 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
CXXC4
|
cell proliferation
|
Bladder Carcinoma
|
Gene: CXXC4 (CXXC finger protein 4)
Type: protein-coding
Summary: This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: Wnt signaling pathway, negative regulation of Wnt signaling pathway, zygotic specification of dorsal/ventral axis; MF: DNA binding, PDZ domain binding, metal ion binding, methyl-CpG binding, zinc ion binding; CC: cytoplasm, cytoplasmic vesicle, nucleus
Pathways: LncRNA involvement in canonical Wnt signaling and colorectal cancer, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), ncRNAs involved in Wnt signaling in hepatocellular carcinoma
UniProt: A0A8V8TLX0, J9JIF5
Entrez ID: 80319
|
Does Knockout of WEE1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
WEE1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: WEE1 (WEE1 G2 checkpoint kinase)
Type: protein-coding
Summary: This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, cell division, establishment of cell polarity, microtubule cytoskeleton organization, mitotic cell cycle, mitotic nuclear membrane disassembly, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of G2/M transition of mitotic cell cycle, neuron projection morphogenesis, nuclear envelope organization, positive regulation of DNA replication, positive regulation of G2/M transition of mitotic cell cycle; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, Ciliary landscape, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Factors involved in megakaryocyte development and platelet production, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, G2/M DNA damage checkpoint, G2/M DNA replication checkpoint, G2/M Transition, Hemostasis, Human immunodeficiency virus 1 infection - Homo sapiens (human), Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, PLK1 signaling events, Polo-like kinase mediated events, Retinoblastoma gene in cancer, S Phase, cdc25 and chk1 regulatory pathway in response to dna damage, cell cycle: g2/m checkpoint, rb tumor suppressor/checkpoint signaling in response to dna damage
UniProt: P30291
Entrez ID: 7465
|
Does Knockout of KMT5C in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
KMT5C
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: KMT5C (lysine methyltransferase 5C)
Type: protein-coding
Summary: SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009].
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, methylation, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of isotype switching; MF: S-adenosyl-L-methionine binding, chromatin binding, histone H4 methyltransferase activity, histone H4K20 methyltransferase activity, histone H4K20 monomethyltransferase activity, histone H4K20me methyltransferase activity, histone binding, metal ion binding, methyltransferase activity, protein binding, transferase activity; CC: chromosome, condensed chromosome, centromeric region, heterochromatin, nucleoplasm, nucleus, pericentric heterochromatin
Pathways: Chromatin modifying enzymes, Chromatin organization, Histone Modifications, Lysine degradation - Homo sapiens (human), PKMTs methylate histone lysines
UniProt: Q86Y97
Entrez ID: 84787
|
Does Knockout of TSG101 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
TSG101
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: TSG101 (tumor susceptibility 101)
Type: protein-coding
Summary: The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: autophagosome maturation, cell differentiation, cell division, endosome to lysosome transport, exosomal secretion, extracellular transport, keratinocyte differentiation, macroautophagy, membrane fission, multivesicular body assembly, negative regulation of cell population proliferation, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of epidermal growth factor-activated receptor activity, negative regulation of transcription by RNA polymerase II, positive regulation of exosomal secretion, positive regulation of ubiquitin-dependent endocytosis, positive regulation of viral budding via host ESCRT complex, protein transport, protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, regulation of MAP kinase activity, regulation of cell cycle, regulation of cell growth, regulation of extracellular exosome assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, viral budding, viral budding via host ESCRT complex, viral release from host cell; MF: DNA binding, calcium-dependent protein binding, protein binding, protein homodimerization activity, protein-containing complex binding, transcription corepressor activity, ubiquitin binding, ubiquitin protein ligase binding, virion binding; CC: ESCRT I complex, Flemming body, centrosome, cytoplasm, cytoskeleton, cytosol, early endosome, early endosome membrane, endosome, endosome membrane, extracellular exosome, late endosome, late endosome membrane, membrane, multivesicular body, nucleolus, nucleus, plasma membrane
Pathways: Ebola Virus Pathway on Host, Endocytosis - Homo sapiens (human), Internalization of ErbB1, TCR
UniProt: Q99816
Entrez ID: 7251
|
Does Knockout of UXT in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
UXT
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: UXT (ubiquitously expressed prefoldin like chaperone)
Type: protein-coding
Summary: The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene may play a role in tumorigenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: apoptotic process, centrosome cycle, microtubule cytoskeleton organization, mitochondrion transport along microtubule, negative regulation of transcription by RNA polymerase II, protein stabilization; MF: actin filament binding, beta-tubulin binding, chromatin binding, microtubule binding, protein binding, transcription corepressor activity; CC: RPAP3/R2TP/prefoldin-like complex, centrosome, chromatin, cytoplasm, cytoskeleton, mediator complex, nucleoplasm, nucleus, protein folding chaperone complex, protein-containing complex, spindle pole
Pathways: E2F transcription factor network, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Transcriptional Regulation by E2F6
UniProt: Q9UBK9
Entrez ID: 8409
|
Does Knockout of OLFML3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
OLFML3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: OLFML3 (olfactomedin like 3)
Type: protein-coding
Summary: This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprotein with a C-terminal olfactomedin domain that facilitates protein-protein interactions, cell adhesion, and intercellular interactions. It serves as both a scaffold protein that recruits bone morphogenetic protein 1 to its substrate chordin, and as a vascular tissue remodeler with pro-angiogenic properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
Gene Ontology: CC: extracellular region, extracellular space, extracellular vesicle
Pathways:
UniProt: Q9NRN5
Entrez ID: 56944
|
Does Knockout of ZNF585B in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
ZNF585B
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: ZNF585B (zinc finger protein 585B)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: developmental process, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q52M93
Entrez ID: 92285
|
Does Knockout of RIC8B in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
RIC8B
|
cell proliferation
|
Melanoma Cell Line
|
Gene: RIC8B (RIC8 guanine nucleotide exchange factor B)
Type: protein-coding
Summary: Enables G-protein alpha-subunit binding activity. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, protein folding, regulation of G protein-coupled receptor signaling pathway, sensory perception of smell; MF: G-protein alpha-subunit binding, guanyl-nucleotide exchange factor activity, protein folding chaperone; CC: cell cortex, centrosome, cytoplasm, cytosol, plasma membrane
Pathways:
UniProt: Q9NVN3
Entrez ID: 55188
|
Does Activation of BEND5 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
BEND5
|
protein/peptide accumulation
|
T cell
|
Gene: BEND5 (BEN domain containing 5)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Involved in negative regulation of transcription, DNA-templated. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription; MF: DNA binding, protein binding
Pathways:
UniProt: Q7L4P6
Entrez ID: 79656
|
Does Knockout of SPANXB1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
SPANXB1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SPANXB1 (SPANX family member B1)
Type: protein-coding
Summary: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular family member contains an additional 18 nucleotides in its coding region compared to the other family members in the same gene cluster. This family member is also subject to gene copy number variation. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Apr 2014].
Gene Ontology: CC: cytoplasm, nucleus
Pathways:
UniProt: Q9NS25
Entrez ID: 728695
|
Does Knockout of KCTD1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
KCTD1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: KCTD1 (potassium channel tetramerization domain containing 1)
Type: protein-coding
Summary: This gene encodes a protein containing a BTB (Broad-complex, tramtrack and bric a brac), also known as a POZ (POxvirus and zinc finger) protein-protein interaction domain. The encoded protein negatively regulates the AP-2 family of transcription factors and the Wnt signaling pathway. A mechanism for the modulation of Wnt signaling has been proposed in which the encoded protein enhances ubiquitination and degradation of the beta-catenin protein. Mutations in this gene have been identified in Scalp-ear-nipple (SEN) syndrome. [provided by RefSeq, May 2017].
Gene Ontology: BP: negative regulation of DNA-templated transcription, protein homooligomerization; MF: identical protein binding, protein binding, transcription corepressor activity, transcription factor binding; CC: nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Negative regulation of activity of TFAP2 (AP-2) family transcription factors, RNA Polymerase II Transcription, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
UniProt: Q719H9
Entrez ID: 284252
|
Does Knockout of NUP153 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
NUP153
|
cell proliferation
|
Bladder Carcinoma
|
Gene: NUP153 (nucleoporin 153)
Type: protein-coding
Summary: Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013].
Gene Ontology: BP: RNA export from nucleus, amyloid fibril formation, mRNA transport, negative regulation of RNA export from nucleus, nuclear pore complex assembly, nucleocytoplasmic transport, protein import into nucleus, protein transport, symbiont entry into host cell, viral penetration into host nucleus; MF: DNA binding, identical protein binding, metal ion binding, molecular condensate scaffold activity, nuclear localization sequence binding, protein binding, protein-membrane adaptor activity, structural constituent of nuclear pore, zinc ion binding; CC: cytosol, host cell, membrane, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore nuclear basket, nucleolus, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Regulation of cytoplasmic and nuclear SMAD2/3 signaling, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TGF-beta Signaling Pathway, TGF_beta_Receptor, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, snRNP Assembly, sumoylation by ranbp2 regulates transcriptional repression, tRNA processing, tRNA processing in the nucleus
UniProt: P49790
Entrez ID: 9972
|
Does Knockout of MDFIC in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
MDFIC
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: MDFIC (MyoD family inhibitor domain containing)
Type: protein-coding
Summary: This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of protein import into nucleus, positive regulation of DNA-templated transcription, positive regulation of viral transcription, regulation of JNK cascade, regulation of Wnt signaling pathway, regulation of gene expression; MF: DNA-binding transcription factor binding, Tat protein binding, cyclin binding, protein binding; CC: cytoplasm, extracellular region, nucleolus, nucleus
Pathways: Regulation of nuclear beta catenin signaling and target gene transcription
UniProt: Q9P1T7
Entrez ID: 29969
|
Does Knockout of PSG5 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
PSG5
|
response to virus
|
Huh-7 Cell
|
Gene: PSG5 (pregnancy specific beta-1-glycoprotein 5)
Type: protein-coding
Summary: The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) family, which belongs to the immunoglobulin superfamily. For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009].
Gene Ontology: BP: female pregnancy, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; CC: cell surface, extracellular region
Pathways: Cell surface interactions at the vascular wall, Hemostasis
UniProt: Q15238
Entrez ID: 5673
|
Does Knockout of CD163L1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
CD163L1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CD163L1 (CD163 molecule like 1)
Type: protein-coding
Summary: This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: CC: cytoplasm, external side of plasma membrane, extracellular region, membrane, plasma membrane
Pathways:
UniProt: Q9NR16
Entrez ID: 283316
|
Does Knockout of ZMPSTE24 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
ZMPSTE24
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: ZMPSTE24 (zinc metallopeptidase STE24)
Type: protein-coding
Summary: This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: CAAX-box protein processing, CAMKK-AMPK signaling cascade, DNA damage response, DNA repair, adult walking behavior, bone mineralization, calcium ion import into sarcoplasmic reticulum, cardiac conduction, cardiac muscle cell development, cardiac ventricle development, cellular response to gamma radiation, chromatin organization, chromosome organization, determination of adult lifespan, epidermis development, epigenetic regulation of gene expression, growth plate cartilage development, hair follicle development, heart morphogenesis, inflammatory cell apoptotic process, kidney morphogenesis, lipid metabolic process, liver development, maintenance of rDNA, multicellular organism growth, negative regulation of gene expression, negative regulation of miRNA processing, neuromuscular process, nuclear envelope organization, nucleus organization, positive regulation of gene expression, positive regulation of gene expression via chromosomal CpG island demethylation, prenylated protein catabolic process, protein maturation, protein processing, proteolysis, regulation of DNA damage response, signal transduction by p53 class mediator, regulation of DNA-templated transcription, regulation of TOR signaling, regulation of autophagy, regulation of blood circulation, regulation of bone mineralization, regulation of cell shape, regulation of cellular senescence, regulation of defense response to virus, regulation of fibroblast proliferation, regulation of glucose metabolic process, regulation of heart contraction, regulation of hormone metabolic process, regulation of lipid metabolic process, regulation of mitotic cell cycle, regulation of mitotic cell cycle DNA replication, regulation of multicellular organism growth, regulation of stress-activated protein kinase signaling cascade, regulation of termination of RNA polymerase I transcription, regulation of ventricular cardiac muscle cell membrane repolarization, response to DNA damage checkpoint signaling, thymus development, ventricular cardiac muscle tissue development; MF: double-stranded DNA binding, endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metalloexopeptidase activity, metallopeptidase activity, peptidase activity, protein binding; CC: early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, extracellular exosome, late endosome membrane, membrane, nuclear envelope, nuclear inner membrane, nucleus, protein-containing complex
Pathways: Adipogenesis, Lamin A-processing pathway, Nephrotic syndrome, Terpenoid backbone biosynthesis - Homo sapiens (human), The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, The influence of laminopathies on Wnt signaling
UniProt: O75844
Entrez ID: 10269
|
Does Knockout of ORC3 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
ORC3
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: ORC3 (origin recognition complex subunit 3)
Type: protein-coding
Summary: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, DNA replication initiation, glial cell proliferation, neural precursor cell proliferation, regulation of DNA replication; MF: DNA binding, DNA replication origin binding, protein binding; CC: DNA replication preinitiation complex, chromatin, chromosome, chromosome, telomeric region, nuclear body, nuclear origin of replication recognition complex, nuclear pre-replicative complex, nucleoplasm, nucleus, origin recognition complex
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the ORC complex at the origin of replication, Assembly of the pre-replicative complex, CDC6 association with the ORC:origin complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), DNA Replication, DNA Replication Pre-Initiation, E2F mediated regulation of DNA replication, E2F-enabled inhibition of pre-replication complex formation, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, cdk regulation of dna replication
UniProt: Q9UBD5
Entrez ID: 23595
|
Does Knockout of RPP25L in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
RPP25L
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: RPP25L (ribonuclease P/MRP subunit p25 like)
Type: protein-coding
Summary: This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that may share one or more domains in common. Members of this family are small archaebacterial proteins with no known function. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: RNA binding, nucleic acid binding, protein binding; CC: nucleus, ribonuclease MRP complex
Pathways: RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q8N5L8
Entrez ID: 138716
|
Does Knockout of ANAPC1 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
ANAPC1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: ANAPC1 (anaphase promoting complex subunit 1)
Type: protein-coding
Summary: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, metaphase/anaphase transition of mitotic cell cycle, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; CC: anaphase-promoting complex, cytosol, nucleoplasm, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9H1A4
Entrez ID: 64682
|
Does Knockout of SNX4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
SNX4
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: SNX4 (sorting nexin 4)
Type: protein-coding
Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: endocytic recycling, positive regulation of autophagosome assembly, positive regulation of histamine secretion by mast cell, protein transport; MF: epidermal growth factor receptor binding, insulin receptor binding, leptin receptor binding, lipid binding, phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, protein binding, transferrin receptor binding; CC: SNARE complex, cytoplasm, cytoplasmic dynein complex, early endosome, early endosome membrane, endosome, membrane, plasma membrane, presynaptic endosome, protein-containing complex
Pathways: Endocytosis - Homo sapiens (human), TGF_beta_Receptor
UniProt: O95219
Entrez ID: 8723
|
Does Knockout of PERP in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
PERP
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PERP (p53 apoptosis effector related to PMP22)
Type: protein-coding
Summary: Involved in activation of cysteine-type endopeptidase activity. Predicted to be located in plasma membrane. Predicted to be active in cell-cell junction. Implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Notch signaling pathway, amelogenesis, apoptotic process, cell adhesion, cell-cell adhesion, desmosome organization, heterotypic cell-cell adhesion, intrinsic apoptotic signaling pathway by p53 class mediator, mammary gland duct morphogenesis, positive regulation of T cell apoptotic process, positive regulation of neutrophil chemotaxis, positive regulation of proteolysis, tissue homeostasis; CC: Golgi apparatus, anchoring junction, cell-cell junction, cytoplasm, desmosome, membrane, mitochondrion, plasma membrane
Pathways: Developmental Biology, Direct p53 effectors, Formation of the cornified envelope, Gene expression (Transcription), Generic Transcription Pathway, Keratinization, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, Transcriptional Regulation by TP53, Validated transcriptional targets of TAp63 isoforms, Validated transcriptional targets of deltaNp63 isoforms, miRNA regulation of p53 pathway in prostate cancer, p53 signaling pathway - Homo sapiens (human), p53 transcriptional gene network
UniProt: Q96FX8
Entrez ID: 64065
|
Does Knockout of TPR in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
TPR
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: TPR (translocated promoter region, nuclear basket protein)
Type: protein-coding
Summary: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA export from nucleus, RNA import into nucleus, cell division, cellular response to heat, cellular response to interferon-alpha, intracellular protein transport, mRNA export from nucleus, mRNA export from nucleus in response to heat stress, mRNA transport, mitotic spindle assembly checkpoint signaling, negative regulation of RNA export from nucleus, negative regulation of transcription by RNA polymerase II, negative regulation of translational initiation, nuclear export, nuclear matrix organization, nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport, positive regulation of heterochromatin formation, positive regulation of intracellular protein transport, positive regulation of mitotic cell cycle spindle assembly checkpoint, positive regulation of nucleocytoplasmic transport, positive regulation of protein export from nucleus, positive regulation of protein import into nucleus, protein export from nucleus, protein import into nucleus, protein transport, regulation of mRNA export from nucleus, regulation of mitotic sister chromatid separation, regulation of mitotic spindle assembly, regulation of protein export from nucleus, regulation of protein import into nucleus, regulation of protein localization, regulation of protein stability, response to epidermal growth factor; MF: RNA binding, chromatin binding, dynein complex binding, heat shock protein binding, mRNA binding, mitogen-activated protein kinase binding, protein binding, protein homodimerization activity, protein-membrane adaptor activity, structural constituent of nuclear pore, tubulin binding; CC: chromosome, chromosome, centromeric region, cytoplasm, cytoplasmic dynein complex, cytoskeleton, kinetochore, membrane, mitotic spindle, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore nuclear basket, nucleoplasm, nucleus, spindle
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Pathways in cancer - Homo sapiens (human), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Thyroid cancer - Homo sapiens (human), Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: P12270
Entrez ID: 7175
|
Does Knockout of MS4A5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
MS4A5
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: MS4A5 (membrane spanning 4-domains A5)
Type: protein-coding
Summary: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. Though this member is not expressed in hematopoietic cells specifically, it may be involved in signal transduction like many of its related family members. The gene encoding this protein is localized to 11q12, among a cluster of family members. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q9H3V2
Entrez ID: 64232
|
Does Knockout of MBD3L2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
MBD3L2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MBD3L2 (methyl-CpG binding domain protein 3 like 2)
Type: protein-coding
Summary: This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein has been found in germ cell tumors and some somatic tissues. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, negative regulation of transcription by RNA polymerase II, regulation of chromatin organization, regulation of transcription by RNA polymerase II; MF: methyl-CpG binding, protein binding; CC: nucleus
Pathways: Signaling events mediated by HDAC Class I
UniProt: Q8NHZ7
Entrez ID: 125997
|
Does Knockout of SRSF7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
SRSF7
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: SRSF7 (serine and arginine rich splicing factor 7)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an N-terminal RNA recognition motif (RRM) for binding RNA and a C-terminal RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2018].
Gene Ontology: BP: RNA splicing, cellular response to leukemia inhibitory factor, mRNA processing, mRNA transport, negative regulation of mRNA splicing, via spliceosome, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, metal ion binding, nucleic acid binding, protein binding, protein domain specific binding, zinc ion binding; CC: cytoplasm, extracellular exosome, nuclear speck, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Gene expression (Transcription), Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q16629
Entrez ID: 6432
|
Does Knockout of MTFR1L in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
MTFR1L
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: MTFR1L (mitochondrial fission regulator 1 like)
Type: protein-coding
Summary: Predicted to be involved in aerobic respiration and mitochondrial fission. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: aerobic respiration, mitochondrial fission; CC: membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q9H019
Entrez ID: 56181
|
Does Knockout of NR2F1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
NR2F1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: NR2F1 (nuclear receptor subfamily 2 group F member 1)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014].
Gene Ontology: BP: cell differentiation, intracellular receptor signaling pathway, negative regulation of neuron projection development, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, signal transduction; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, nuclear receptor activity, protein binding, retinoic acid-responsive element binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Adipogenesis, Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, Nuclear receptors, RNA Polymerase II Transcription, mechanism of gene regulation by peroxisome proliferators via ppara
UniProt: P10589
Entrez ID: 7025
|
Does Knockout of EEF1AKMT3 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
EEF1AKMT3
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: EEF1AKMT3 (EEF1A lysine methyltransferase 3)
Type: protein-coding
Summary: Enables heat shock protein binding activity and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Located in several cellular components, including centrosome; chromosome; and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: methylation, peptidyl-lysine methylation; MF: heat shock protein binding, methyltransferase activity, protein binding, protein-lysine N-methyltransferase activity, transferase activity; CC: centrosome, chromosome, cytoplasm, cytoskeleton, cytosol, nucleoplasm, protein-containing complex
Pathways:
UniProt: Q96AZ1
Entrez ID: 25895
|
Does Knockout of DHRS4L2 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
DHRS4L2
|
response to chemicals
|
Melanoma Cell Line
|
Gene: DHRS4L2 (dehydrogenase/reductase 4 like 2)
Type: protein-coding
Summary: This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010].
Gene Ontology: MF: carbonyl reductase (NADPH) activity, oxidoreductase activity; CC: extracellular region, mitochondrion, peroxisome
Pathways: Retinol metabolism - Homo sapiens (human)
UniProt: Q6PKH6
Entrez ID: 317749
|
Does Knockout of CCER1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
CCER1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: CCER1 (coiled-coil glutamate rich protein 1)
Type: protein-coding
Summary: coiled-coil glutamate rich protein 1
Gene Ontology: BP: cell differentiation, sperm DNA condensation, spermatogenesis; CC: nucleus
Pathways:
UniProt: Q8TC90
Entrez ID: 196477
|
Does Knockout of IL19 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
IL19
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: IL19 (interleukin 19)
Type: protein-coding
Summary: The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, immune response, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of low-density lipoprotein particle clearance, positive regulation of apoptotic signaling pathway, positive regulation of intrinsic apoptotic signaling pathway, reactive oxygen species metabolic process, signal transduction; MF: cytokine activity, protein binding; CC: extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human), IL23-mediated signaling events, JAK-STAT signaling pathway - Homo sapiens (human), Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: Q9UHD0
Entrez ID: 29949
|
Does Knockout of GKN2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
GKN2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: GKN2 (gastrokine 2)
Type: protein-coding
Summary: The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: NLRP3 inflammasome complex assembly, gene expression, inflammatory response, neutrophil activation involved in immune response, regulation of cell population proliferation, response to bacterium, response to cortisol, response to stress, response to wounding; CC: basal part of cell, extracellular region, extracellular space
Pathways:
UniProt: Q86XP6
Entrez ID: 200504
|
Does Knockout of GJD4 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
GJD4
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: GJD4 (gap junction protein delta 4)
Type: protein-coding
Summary: Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell communication, cell-cell signaling, regulation of satellite cell activation involved in skeletal muscle regeneration, transmembrane transport; CC: anchoring junction, connexin complex, gap junction, membrane, plasma membrane
Pathways: Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q96KN9
Entrez ID: 219770
|
Does Knockout of IFNA13 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
IFNA13
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: IFNA13 (interferon alpha 13)
Type: protein-coding
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: Autoimmune thyroid disease - Homo sapiens (human), Coronavirus disease - COVID-19 - Homo sapiens (human), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), DDX58/IFIH1-mediated induction of interferon-alpha/beta, Disease, Downstream signaling in naïve CD8+ T cells, Epstein-Barr virus infection - Homo sapiens (human), Evasion by RSV of host interferon responses, Factors involved in megakaryocyte development and platelet production, Hemostasis, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Infectious disease, Influenza A - Homo sapiens (human), Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, JAK-STAT signaling pathway - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Measles - Homo sapiens (human), NOD-like receptor signaling pathway - Homo sapiens (human), Natural killer cell mediated cytotoxicity - Homo sapiens (human), Necroptosis - Homo sapiens (human), Overview of interferons-mediated signaling pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), RIG-I-like receptor signaling pathway - Homo sapiens (human), RSV-host interactions, Regulation of IFNA/IFNB signaling, Regulation of toll-like receptor signaling pathway, Respiratory Syncytial Virus Infection Pathway, SARS coronavirus and innate immunity, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, TRAF6 mediated IRF7 activation, Toll-like Receptor Signaling Pathway, Toll-like receptor signaling pathway - Homo sapiens (human), Tuberculosis - Homo sapiens (human), Viral Infection Pathways, double stranded rna induced gene expression, ifn alpha signaling pathway, signal transduction through il1r
UniProt: P01562
Entrez ID: 3447
|
Does Knockout of DROSHA in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
DROSHA
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: DROSHA (drosha ribonuclease III)
Type: protein-coding
Summary: This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: RNA processing, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, miRNA metabolic process, miRNA processing, positive regulation of gene expression, pre-miRNA processing, primary miRNA processing, rRNA processing, regulation of gene expression, regulation of inflammatory response, regulation of miRNA metabolic process, regulation of regulatory T cell differentiation, regulatory ncRNA-mediated gene silencing, ribosome biogenesis; MF: DEAD/H-box RNA helicase binding, R-SMAD binding, RNA binding, RNA endonuclease activity, SMAD binding, endonuclease activity, hydrolase activity, lipopolysaccharide binding, metal ion binding, nuclease activity, primary miRNA binding, protein binding, protein homodimerization activity, ribonuclease III activity; CC: cytoplasm, cytosol, glutamatergic synapse, microprocessor complex, nucleolus, nucleoplasm, nucleus, organelle, postsynaptic density
Pathways: 22q11.2 copy number variation syndrome, DDX1 as a regulatory component of the Drosha microprocessor, Direct p53 effectors, Gene Silencing by RNA, Gene expression (Transcription), MicroRNA (miRNA) biogenesis, Proteoglycans in cancer - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), exRNA mechanism of action and biogenesis, miRNA Biogenesis
UniProt: Q9NRR4
Entrez ID: 29102
|
Does Knockout of SEM1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
SEM1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SEM1 (SEM1 26S proteasome subunit)
Type: protein-coding
Summary: The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: double-strand break repair via homologous recombination, mRNA export from nucleus, proteasome assembly, proteasome-mediated ubiquitin-dependent protein catabolic process; CC: cytosol, integrator complex, nucleoplasm, nucleus, proteasome complex, proteasome regulatory particle, lid subcomplex, protein-containing complex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Defective homologous recombination repair (HRR) due to BRCA1 loss of function, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Defective homologous recombination repair (HRR) due to PALB2 loss of function, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Impaired BRCA2 binding to RAD51, Impaired BRCA2 binding to SEM1 (DSS1), Impaired BRCA2 translocation to the nucleus, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Presynaptic phase of homologous DNA pairing and strand exchange, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q6ZVN7, P60896
Entrez ID: 7979
|
Does Knockout of RCHY1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
RCHY1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RCHY1 (ring finger and CHY zinc finger domain containing 1)
Type: protein-coding
Summary: The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013].
Gene Ontology: BP: error-free translesion synthesis, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein ubiquitination, protein autoubiquitination, protein ubiquitination, rescue of stalled ribosome, ubiquitin-dependent protein catabolic process; MF: metal ion binding, p53 binding, protein binding, protein homodimerization activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nuclear speck, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adaptive Immune System, AndrogenReceptor, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, DNA Damage Bypass, DNA Repair, Direct p53 effectors, Immune System, Measles - Homo sapiens (human), Metabolism of proteins, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Translation, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Ubiquitin mediated proteolysis - Homo sapiens (human), p53 signaling pathway - Homo sapiens (human), p73 transcription factor network
UniProt: Q96PM5
Entrez ID: 25898
|
Does Knockout of MBLAC2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
MBLAC2
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: MBLAC2 (metallo-beta-lactamase domain containing 2)
Type: protein-coding
Summary: Enables palmitoyl-CoA hydrolase activity. Located in endoplasmic reticulum membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: fatty acid metabolic process, lipid metabolic process; MF: beta-lactamase activity, hydrolase activity, long-chain fatty acyl-CoA hydrolase activity, metal ion binding, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, membrane, mitochondrion, plasma membrane
Pathways:
UniProt: Q68D91
Entrez ID: 153364
|
Does Knockout of TTC27 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
TTC27
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TTC27 (tetratricopeptide repeat domain 27)
Type: protein-coding
Summary: tetratricopeptide repeat domain 27
Gene Ontology:
Pathways:
UniProt: Q6P3X3
Entrez ID: 55622
|
Does Knockout of PPP4C in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
PPP4C
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: PPP4C (protein phosphatase 4 catalytic subunit)
Type: protein-coding
Summary: Enables protein serine/threonine phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: double-strand break repair via homologous recombination, regulation of double-strand break repair, regulation of double-strand break repair via homologous recombination; MF: hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity; CC: centrosome, chromatin, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, plasma membrane, protein phosphatase 4 complex
Pathways: 16p11.2 proximal deletion syndrome, DNA Double-Strand Break Repair, DNA Repair, Glucagon signaling pathway - Homo sapiens (human), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends
UniProt: P60510
Entrez ID: 5531
|
Does Knockout of SKP2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
SKP2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: SKP2 (S-phase kinase associated protein 2)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: DNA double-strand break processing, G1/S transition of mitotic cell cycle, G2/M transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cellular response to cell-matrix adhesion, defense response to virus, immune system process, innate immune response, positive regulation of double-strand break repair via homologous recombination, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of protein polyubiquitination, positive regulation of smooth muscle cell proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein K63-linked ubiquitination, protein localization to site of double-strand break, protein polyubiquitination, protein ubiquitination, regulation of apoptotic process, regulation of cell cycle, ubiquitin-dependent protein catabolic process; MF: identical protein binding, protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: SCF ubiquitin ligase complex, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: C-MYC pathway, Cell cycle, Cell cycle - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), FOXM1 transcription factor network, FoxO family signaling, FoxO signaling pathway - Homo sapiens (human), Imatinib and Chronic Myeloid Leukemia, Notch, Notch signaling pathway, Pathways in cancer - Homo sapiens (human), Regulation of retinoblastoma protein, Retinoblastoma gene in cancer, Small cell lung cancer - Homo sapiens (human), Ubiquitin mediated proteolysis - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), e2f1 destruction pathway, mTOR signaling pathway - Homo sapiens (human), p53 pathway, regulation of p27 phosphorylation during cell cycle progression
UniProt: Q13309
Entrez ID: 6502
|
Does Knockout of MC2R in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
MC2R
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: MC2R (melanocortin 2 receptor)
Type: protein-coding
Summary: MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, adenylate cyclase-activating G protein-coupled receptor signaling pathway, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled receptor activity, corticotropin receptor activity, melanocortin receptor activity, protein binding; CC: cytoplasm, membrane, plasma membrane
Pathways: Aldosterone synthesis and secretion - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), Corticotropin Activation of Cortisol Production, Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Defective ACTH causes obesity and POMCD, Disease, Diseases of metabolism, G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide GPCRs, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Homo sapiens (human)
UniProt: Q01718
Entrez ID: 4158
|
Does Knockout of CYC1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
CYC1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: CYC1 (cytochrome c1)
Type: protein-coding
Summary: This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, proton transmembrane transport, response to glucagon; MF: electron transfer activity, heme binding, metal ion binding, protein binding, quinol-cytochrome-c reductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleus, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Complex III assembly, Diabetic cardiomyopathy - Homo sapiens (human), Huntington disease - Homo sapiens (human), Metabolism, Mitochondrial complex III assembly, Mitochondrial protein import, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Protein localization, Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: P08574
Entrez ID: 1537
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