prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of KMT2A in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | KMT2A | cell proliferation | Monocytic Leukemia Cell Line | Gene: KMT2A (lysine methyltransferase 2A)
Type: protein-coding
Summary: This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these ... |
Does Knockout of BZW2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | BZW2 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: BZW2 (basic leucine zipper and W2 domains 2)
Type: protein-coding
Summary: Enables cadherin binding activity. Predicted to be involved in cell differentiation and nervous system development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regu... |
Does Knockout of USPL1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | USPL1 | cell proliferation | Glioblastoma Cell Line | Gene: USPL1 (ubiquitin specific peptidase like 1)
Type: protein-coding
Summary: Enables SUMO binding activity and SUMO-specific isopeptidase activity. Involved in several processes, including Cajal body organization; protein desumoylation; and snRNA transcription. Located in Cajal body. [provided by All... |
Does Knockout of LYN in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | LYN | cell proliferation | Bladder Carcinoma | Gene: LYN (LYN proto-oncogene, Src family tyrosine kinase)
Type: protein-coding
Summary: This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms ha... |
Does Activation of ASNSD1 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | ASNSD1 | protein/peptide accumulation | T cell | Gene: ASNSD1 (asparagine synthetase domain containing 1)
Type: protein-coding
Summary: Predicted to enable asparagine synthase (glutamine-hydrolyzing) activity. Predicted to be involved in asparagine biosynthetic process and glutamine metabolic process. [provided by Alliance of Genome Resources, Apr 202... |
Does Knockout of BET1 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | BET1 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: BET1 (Bet1 golgi vesicular membrane trafficking protein)
Type: protein-coding
Summary: This gene encodes a golgi-associated membrane protein that participates in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex. The encoded protein functions as a soluble N-ethylaleimide... |
Does Knockout of CTSC in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | CTSC | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: CTSC (cathepsin C)
Type: protein-coding
Summary: This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transc... |
Does Knockout of ADIPOR1 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | ADIPOR1 | response to virus | Lung Cancer Cell Line | Gene: ADIPOR1 (adiponectin receptor 1)
Type: protein-coding
Summary: This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an ... |
Does Knockout of TPSAB1 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | TPSAB1 | response to virus | Hepatoma Cell Line | Gene: TPSAB1 (tryptase alpha/beta 1)
Type: protein-coding
Summary: Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several... |
Does Knockout of NEURL2 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | NEURL2 | cell proliferation | Cancer Cell Line | Gene: NEURL2 (neuralized E3 ubiquitin protein ligase 2)
Type: protein-coding
Summary: This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquit... |
Does Knockout of GPR183 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | GPR183 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: GPR183 (G protein-coupled receptor 183)
Type: protein-coding
Summary: This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thromb... |
Does Knockout of MED4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | MED4 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: MED4 (mediator complex subunit 4)
Type: protein-coding
Summary: This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encod... |
Does Knockout of RPL36AL in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | RPL36AL | cell proliferation | T-lymphoma cell line | Gene: RPL36AL (ribosomal protein L36a like)
Type: protein-coding
Summary: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. ... |
Does Knockout of COG4 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | COG4 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: COG4 (component of oligomeric golgi complex 4)
Type: protein-coding
Summary: The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation t... |
Does Knockout of SLF1 in Prostate Cancer Cell Line causally result in response to chemicals? | 1 | 2,109 | Knockout | SLF1 | response to chemicals | Prostate Cancer Cell Line | Gene: SLF1 (SMC5/6 complex localization factor 1)
Type: protein-coding
Summary: Enables ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of double-strand break repair; and protein localization ... |
Does Knockout of MARVELD3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | MARVELD3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: MARVELD3 (MARVEL domain containing 3)
Type: protein-coding
Summary: Enables mitogen-activated protein kinase kinase kinase binding activity. Involved in bicellular tight junction assembly. Acts upstream of or within several processes, including negative regulation of JNK cascade; negative regulati... |
Does Knockout of PRR23A in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | PRR23A | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: PRR23A (proline rich 23A)
Type: protein-coding
Summary: proline rich 23A
Gene Ontology:
Pathways:
UniProt: A6NEV1
Entrez ID: 729627 |
Does Knockout of ACTR2 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | ACTR2 | cell proliferation | Cancer Cell Line | Gene: ACTR2 (actin related protein 2)
Type: protein-coding
Summary: The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and mot... |
Does Knockout of PSMD2 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 1 | 1,480 | Knockout | PSMD2 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical s... |
Does Knockout of BHLHE41 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | BHLHE41 | response to virus | Hepatoma Cell Line | Gene: BHLHE41 (basic helix-loop-helix family member e41)
Type: protein-coding
Summary: This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTL's transac... |
Does Knockout of TOP1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | TOP1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: TOP1 (DNA topoisomerase I)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass... |
Does Knockout of COPA in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | COPA | cell proliferation | Endometrial Cancer Cell Line | Gene: COPA (coat protein complex I subunit alpha)
Type: protein-coding
Summary: In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they re... |
Does Knockout of DRD1 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | DRD1 | cell proliferation | Hepatoma Cell Line | Gene: DRD1 (dopamine receptor D1)
Type: protein-coding
Summary: This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent p... |
Does Knockout of PPP2CA in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | PPP2CA | cell proliferation | Gastric Cancer Cell Line | Gene: PPP2CA (protein phosphatase 2 catalytic subunit alpha)
Type: protein-coding
Summary: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists o... |
Does Knockout of CCL25 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | CCL25 | cell proliferation | Neuroblastoma Cell Line | Gene: CCL25 (C-C motif chemokine ligand 25)
Type: protein-coding
Summary: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two a... |
Does Knockout of TUBGCP5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | TUBGCP5 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: TUBGCP5 (tubulin gamma complex component 5)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: B... |
Does Knockout of POTEG in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | POTEG | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: POTEG (POTE ankyrin domain family member G)
Type: protein-coding
Summary: POTE ankyrin domain family member G
Gene Ontology:
Pathways:
UniProt: Q6S5H5
Entrez ID: 404785 |
Does Knockout of PRR18 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | PRR18 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: PRR18 (proline rich 18)
Type: protein-coding
Summary: proline rich 18
Gene Ontology:
Pathways:
UniProt: Q8N4B5
Entrez ID: 285800 |
Does Knockout of ATG14 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | ATG14 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: ATG14 (autophagy related 14)
Type: protein-coding
Summary: Enables GTPase binding activity. Involved in several processes, including macroautophagy; regulation of phosphorylation; and response to mitochondrial depolarisation. Acts upstream of or within endosome to lysosome transport. Located in au... |
Does Activation of NRCAM in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | NRCAM | response to virus | Hepatoma Cell Line | Gene: NRCAM (neuronal cell adhesion molecule)
Type: protein-coding
Summary: Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-b... |
Does Knockout of ZBP1 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | ZBP1 | cell proliferation | Gastric Cancer Cell Line | Gene: ZBP1 (Z-DNA binding protein 1)
Type: protein-coding
Summary: This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple is... |
Does Knockout of SEC31B in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | SEC31B | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: SEC31B (SEC31 homolog B, COPII component)
Type: protein-coding
Summary: This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylat... |
Does Knockout of CFAP20 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | CFAP20 | cell proliferation | Endometrial Cancer Cell Line | Gene: CFAP20 (cilia and flagella associated protein 20)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in several processes, including positive regulation of feeding behavior; protein polyglutamylation; and regulation of cell motility. Located in centriole; ciliary basal body; and ... |
Does Knockout of NEMP2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | NEMP2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: NEMP2 (nuclear envelope integral membrane protein 2)
Type: protein-coding
Summary: Predicted to be located in nuclear inner membrane. Predicted to be integral component of membrane. Predicted to be active in nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontol... |
Does Knockout of NEK8 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | NEK8 | response to chemicals | Colorectal Cancer Cell Line | Gene: NEK8 (NIMA related kinase 8)
Type: protein-coding
Summary: This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in th... |
Does Knockout of GADD45B in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | GADD45B | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: GADD45B (growth arrest and DNA damage inducible beta)
Type: protein-coding
Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental ... |
Does Knockout of DDX23 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | DDX23 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: DDX23 (DEAD-box helicase 23)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alterati... |
Does Knockout of DPY19L2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | DPY19L2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: DPY19L2 (dpy-19 like 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility ... |
Does Knockout of DNA2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | DNA2 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: DNA2 (DNA replication helicase/nuclease 2)
Type: protein-coding
Summary: This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated w... |
Does Inhibition of SF3B3 in Gastric tumor organoid model causally result in response to chemicals? | 0 | 2,482 | Inhibition | SF3B3 | response to chemicals | Gastric tumor organoid model | Gene: SF3B3 (splicing factor 3b subunit 3)
Type: protein-coding
Summary: This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3... |
Does Knockout of MED11 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | MED11 | cell proliferation | Cancer Cell Line | Gene: MED11 (mediator complex subunit 11)
Type: protein-coding
Summary: MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008].
Gene Ontolog... |
Does Knockout of CDC7 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | CDC7 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: CDC7 (cell division cycle 7)
Type: protein-coding
Summary: This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene produ... |
Does Knockout of GGN in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | GGN | response to chemicals | Monocytic Leukemia Cell Line | Gene: GGN (gametogenetin)
Type: protein-coding
Summary: This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin prot... |
Does Knockout of VEGFB in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | VEGFB | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: VEGFB (vascular endothelial growth factor B)
Type: protein-coding
Summary: This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell ... |
Does Knockout of PGAM1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | PGAM1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PGAM1 (phosphoglycerate mutase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been f... |
Does Knockout of RND1 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | RND1 | cell proliferation | Cancer Cell Line | Gene: RND1 (Rho family GTPase 1)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule ... |
Does Knockout of THY1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | THY1 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: THY1 (Thy-1 cell surface antigen)
Type: protein-coding
Summary: This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the i... |
Does Knockout of KRTDAP in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | KRTDAP | cell proliferation | Medulloblastoma Cell Line | Gene: KRTDAP (keratinocyte differentiation associated protein)
Type: protein-coding
Summary: This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance of stratified epithelia. Multiple transcript variants encoding different isoforms have been found ... |
Does Knockout of SLC35G5 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | SLC35G5 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: SLC35G5 (solute carrier family 35 member G5)
Type: protein-coding
Summary: This gene is intronless and probably arose from retrotransposition of a similar gene. It has high sequence similarity to the gene encoding acyl-malonyl condensing enzyme on chromosome 17. [provided by RefSeq, Aug 2011].
... |
Does Knockout of FAM83F in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | FAM83F | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: FAM83F (family with sequence similarity 83 member F)
Type: protein-coding
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, protein kinase ... |
Does Knockout of RMND5A in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | RMND5A | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: RMND5A (required for meiotic nuclear division 5 homolog A)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquiti... |
Does Knockout of DDX59 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | DDX59 | cell proliferation | Glioblastoma Cell Line | Gene: DDX59 (DEAD-box helicase 59)
Type: protein-coding
Summary: Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be located in cytoplasm and nucleus. Predicted to be integral component of membrane. Implicated in orofaciodigital syndrome V. [provided by Alliance of Genome... |
Does Knockout of SNHG28 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | SNHG28 | response to virus | Huh-7 Cell | Gene: SNHG28 (small nucleolar RNA host gene 28)
Type: ncRNA
Summary: Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 284677 |
Does Knockout of DTL in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | DTL | cell proliferation | Monocytic Leukemia Cell Line | Gene: DTL (denticleless E3 ubiquitin protein ligase adapter)
Type: protein-coding
Summary: Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in ce... |
Does Knockout of TOPBP1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | TOPBP1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: TOPBP1 (DNA topoisomerase II binding protein 1)
Type: protein-coding
Summary: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta th... |
Does Knockout of ACVR1B in Glioma Cell Line causally result in protein/peptide accumulation? | 0 | 589 | Knockout | ACVR1B | protein/peptide accumulation | Glioma Cell Line | Gene: ACVR1B (activin A receptor type 1B)
Type: protein-coding
Summary: This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins... |
Does Knockout of DNM2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | DNM2 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: DNM2 (dynamin 2)
Type: protein-coding
Summary: Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They hav... |
Does Knockout of CXXC4 in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | CXXC4 | cell proliferation | Bladder Carcinoma | Gene: CXXC4 (CXXC finger protein 4)
Type: protein-coding
Summary: This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through int... |
Does Knockout of WEE1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | WEE1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: WEE1 (WEE1 G2 checkpoint kinase)
Type: protein-coding
Summary: This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the t... |
Does Knockout of KMT5C in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | KMT5C | response to virus | Cervical Adenocarcinoma Cell Line | Gene: KMT5C (lysine methyltransferase 5C)
Type: protein-coding
Summary: SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplie... |
Does Knockout of TSG101 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | TSG101 | cell proliferation | Breast Cancer Cell Line | Gene: TSG101 (tumor susceptibility 101)
Type: protein-coding
Summary: The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated i... |
Does Knockout of UXT in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | UXT | cell proliferation | Colonic Cancer Cell Line | Gene: UXT (ubiquitously expressed prefoldin like chaperone)
Type: protein-coding
Summary: The protein encoded by this gene functions as a cofactor that modulates androgen receptor-dependent transcription, and also plays a critical role in tumor necrosis factor-induced apoptosis. Expression of this gene ... |
Does Knockout of OLFML3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | OLFML3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: OLFML3 (olfactomedin like 3)
Type: protein-coding
Summary: This gene encodes a member of the olfactomedin-like gene family which also includes genes encoding noelin, tiarin, myocilin, amassin, optimedin, photomedin, and latrophilin. The encoded protein is a secreted extracellular matrix glycoprote... |
Does Knockout of ZNF585B in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | ZNF585B | cell proliferation | Prostate Cancer Cell Line | Gene: ZNF585B (zinc finger protein 585B)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription ... |
Does Knockout of RIC8B in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | RIC8B | cell proliferation | Melanoma Cell Line | Gene: RIC8B (RIC8 guanine nucleotide exchange factor B)
Type: protein-coding
Summary: Enables G-protein alpha-subunit binding activity. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources... |
Does Activation of BEND5 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | BEND5 | protein/peptide accumulation | T cell | Gene: BEND5 (BEN domain containing 5)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Involved in negative regulation of transcription, DNA-templated. Predicted to be located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: nega... |
Does Knockout of SPANXB1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | SPANXB1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SPANXB1 (SPANX family member B1)
Type: protein-coding
Summary: Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatoz... |
Does Knockout of KCTD1 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | KCTD1 | cell proliferation | Gastric Cancer Cell Line | Gene: KCTD1 (potassium channel tetramerization domain containing 1)
Type: protein-coding
Summary: This gene encodes a protein containing a BTB (Broad-complex, tramtrack and bric a brac), also known as a POZ (POxvirus and zinc finger) protein-protein interaction domain. The encoded protein negatively reg... |
Does Knockout of NUP153 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | NUP153 | cell proliferation | Bladder Carcinoma | Gene: NUP153 (nucleoporin 153)
Type: protein-coding
Summary: Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins... |
Does Knockout of MDFIC in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | MDFIC | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: MDFIC (MyoD family inhibitor domain containing)
Type: protein-coding
Summary: This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initi... |
Does Knockout of PSG5 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | PSG5 | response to virus | Huh-7 Cell | Gene: PSG5 (pregnancy specific beta-1-glycoprotein 5)
Type: protein-coding
Summary: The human pregnancy-specific glycoproteins (PSGs) are a group of molecules that are mainly produced by the placental syncytiotrophoblasts during pregnancy. PSGs comprise a subgroup of the carcinoembryonic antigen (CEA) f... |
Does Knockout of CD163L1 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | CD163L1 | cell proliferation | Glioblastoma Cell Line | Gene: CD163L1 (CD163 molecule like 1)
Type: protein-coding
Summary: This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined... |
Does Knockout of ZMPSTE24 in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | ZMPSTE24 | cell proliferation | Prostate Cancer Cell Line | Gene: ZMPSTE24 (zinc metallopeptidase STE24)
Type: protein-coding
Summary: This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to ... |
Does Knockout of ORC3 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | ORC3 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: ORC3 (origin recognition complex subunit 3)
Type: protein-coding
Summary: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to or... |
Does Knockout of RPP25L in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | RPP25L | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: RPP25L (ribonuclease P/MRP subunit p25 like)
Type: protein-coding
Summary: This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that may share one or more domains in common. Members of this family are small archaebacterial proteins with no know... |
Does Knockout of ANAPC1 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | ANAPC1 | cell proliferation | Astrocytoma Cell Line | Gene: ANAPC1 (anaphase promoting complex subunit 1)
Type: protein-coding
Summary: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which ... |
Does Knockout of SNX4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | SNX4 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: SNX4 (sorting nexin 4)
Type: protein-coding
Summary: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform o... |
Does Knockout of PERP in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | PERP | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PERP (p53 apoptosis effector related to PMP22)
Type: protein-coding
Summary: Involved in activation of cysteine-type endopeptidase activity. Predicted to be located in plasma membrane. Predicted to be active in cell-cell junction. Implicated in erythrokeratodermia variabilis and mutilating palmopl... |
Does Knockout of TPR in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | TPR | cell proliferation | Medulloblastoma Cell Line | Gene: TPR (translocated promoter region, nuclear basket protein)
Type: protein-coding
Summary: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC... |
Does Knockout of MS4A5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | MS4A5 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: MS4A5 (membrane spanning 4-domains A5)
Type: protein-coding
Summary: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression pa... |
Does Knockout of MBD3L2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | MBD3L2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: MBD3L2 (methyl-CpG binding domain protein 3 like 2)
Type: protein-coding
Summary: This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein has been found in germ cell tumors and some somatic tissues. [provided by RefSeq, Jul 20... |
Does Knockout of SRSF7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | SRSF7 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: SRSF7 (serine and arginine rich splicing factor 7)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an N-terminal RNA recognition... |
Does Knockout of MTFR1L in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | MTFR1L | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: MTFR1L (mitochondrial fission regulator 1 like)
Type: protein-coding
Summary: Predicted to be involved in aerobic respiration and mitochondrial fission. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: aerobic respiration, mi... |
Does Knockout of NR2F1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | NR2F1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: NR2F1 (nuclear receptor subfamily 2 group F member 1)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boo... |
Does Knockout of EEF1AKMT3 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | EEF1AKMT3 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: EEF1AKMT3 (EEF1A lysine methyltransferase 3)
Type: protein-coding
Summary: Enables heat shock protein binding activity and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine methylation. Located in several cellular components, including centrosome; chromosome; and nucleoplasm... |
Does Knockout of DHRS4L2 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | DHRS4L2 | response to chemicals | Melanoma Cell Line | Gene: DHRS4L2 (dehydrogenase/reductase 4 like 2)
Type: protein-coding
Summary: This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefS... |
Does Knockout of CCER1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | CCER1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: CCER1 (coiled-coil glutamate rich protein 1)
Type: protein-coding
Summary: coiled-coil glutamate rich protein 1
Gene Ontology: BP: cell differentiation, sperm DNA condensation, spermatogenesis; CC: nucleus
Pathways:
UniProt: Q8TC90
Entrez ID: 196477 |
Does Knockout of IL19 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | IL19 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: IL19 (interleukin 19)
Type: protein-coding
Summary: The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transdu... |
Does Knockout of GKN2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | GKN2 | cell proliferation | Colonic Cancer Cell Line | Gene: GKN2 (gastrokine 2)
Type: protein-coding
Summary: The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric ... |
Does Knockout of GJD4 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | GJD4 | response to chemicals | Colorectal Cancer Cell Line | Gene: GJD4 (gap junction protein delta 4)
Type: protein-coding
Summary: Connexins, such as GJD4, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of whic... |
Does Knockout of IFNA13 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | IFNA13 | cell proliferation | Ovarian Cancer Cell Line | Gene: IFNA13 (interferon alpha 13)
Type: protein-coding
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation o... |
Does Knockout of DROSHA in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | DROSHA | cell proliferation | Prostate Cancer Cell Line | Gene: DROSHA (drosha ribonuclease III)
Type: protein-coding
Summary: This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cl... |
Does Knockout of SEM1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | SEM1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SEM1 (SEM1 26S proteasome subunit)
Type: protein-coding
Summary: The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmenta... |
Does Knockout of RCHY1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | RCHY1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: RCHY1 (ring finger and CHY zinc finger domain containing 1)
Type: protein-coding
Summary: The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and c... |
Does Knockout of MBLAC2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | MBLAC2 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: MBLAC2 (metallo-beta-lactamase domain containing 2)
Type: protein-coding
Summary: Enables palmitoyl-CoA hydrolase activity. Located in endoplasmic reticulum membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: fatty acid metabolic process, ... |
Does Knockout of TTC27 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | TTC27 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: TTC27 (tetratricopeptide repeat domain 27)
Type: protein-coding
Summary: tetratricopeptide repeat domain 27
Gene Ontology:
Pathways:
UniProt: Q6P3X3
Entrez ID: 55622 |
Does Knockout of PPP4C in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | PPP4C | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: PPP4C (protein phosphatase 4 catalytic subunit)
Type: protein-coding
Summary: Enables protein serine/threonine phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Gen... |
Does Knockout of SKP2 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | SKP2 | cell proliferation | Endometrial Cancer Cell Line | Gene: SKP2 (S-phase kinase associated protein 2)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex call... |
Does Knockout of MC2R in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | MC2R | cell proliferation | Prostate Cancer Cell Line | Gene: MC2R (melanocortin 2 receptor)
Type: protein-coding
Summary: MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is ... |
Does Knockout of CYC1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | CYC1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: CYC1 (cytochrome c1)
Type: protein-coding
Summary: This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitocho... |
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