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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of CIAPIN1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
CIAPIN1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CIAPIN1 (cytokine induced apoptosis inhibitor 1)
Type: protein-coding
Summary: CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: apoptotic process, hemopoiesis, iron-sulfur cluster assembly, negative regulation of apoptotic process; MF: 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, electron transfer activity, iron ion binding, iron-sulfur cluster binding, metal ion binding, protein binding; CC: cytoplasm, mitochondrial intermembrane space, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q6FI81
Entrez ID: 57019
|
Does Knockout of SART1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
SART1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SART1 (spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP)
Type: protein-coding
Summary: This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, maturation of 5S rRNA, positive regulation of cytotoxic T cell differentiation, spliceosomal snRNP assembly; MF: RNA binding, protein binding; CC: Cajal body, Golgi apparatus, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, catalytic step 2 spliceosome, cytoplasm, cytosol, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O43290
Entrez ID: 9092
|
Does Knockout of MAP4 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
MAP4
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: MAP4 (microtubule associated protein 4)
Type: protein-coding
Summary: The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: cell division, cilium disassembly, establishment of spindle orientation, microtubule cytoskeleton organization, microtubule polymerization, microtubule sliding, mitotic spindle organization, negative regulation of non-motile cilium assembly, neuron projection development; MF: RNA binding, microtubule binding, microtubule stabilizing activity, protein binding, structural molecule activity, tubulin binding; CC: axon, axoneme, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, microtubule, microtubule associated complex, microtubule cytoskeleton, microtubule organizing center, mitotic spindle, neuron projection, plasma membrane
Pathways: Splicing factor NOVA regulated synaptic proteins
UniProt: P27816
Entrez ID: 4134
|
Does Knockout of NCBP1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
NCBP1
|
cell proliferation
|
Cancer Cell Line
|
Gene: NCBP1 (nuclear cap binding protein subunit 1)
Type: protein-coding
Summary: The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 7-methylguanosine mRNA capping, RNA catabolic process, RNA metabolic process, RNA splicing, alternative mRNA splicing, via spliceosome, cap-dependent translational initiation, defense response to virus, histone mRNA metabolic process, mRNA 3'-end processing, mRNA export from nucleus, mRNA metabolic process, mRNA processing, mRNA splicing, via spliceosome, mRNA transcription by RNA polymerase II, mRNA transport, miRNA-mediated post-transcriptional gene silencing, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of RNA binding, positive regulation of cell growth, positive regulation of mRNA 3'-end processing, positive regulation of mRNA splicing, via spliceosome, positive regulation of transcription elongation by RNA polymerase II, primary miRNA processing, regulation of mRNA processing, regulation of translation, regulation of translational initiation, regulatory ncRNA-mediated gene silencing, regulatory ncRNA-mediated post-transcriptional gene silencing, snRNA export from nucleus, spliceosomal complex assembly; MF: RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, mRNA binding, molecular adaptor activity, protein binding; CC: RNA cap binding complex, cytoplasm, cytosol, mitochondrion, nuclear cap binding complex, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: 3q29 copy number variation syndrome, Abortive elongation of HIV-1 transcript in the absence of Tat, Amyotrophic lateral sclerosis - Homo sapiens (human), Axon guidance, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Metabolism of non-coding RNA, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear RNA decay, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Termination, RNA polymerase II transcribes snRNA genes, RNA transport - Homo sapiens (human), Regulation of expression of SLITs and ROBOs, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Spliceosome - Homo sapiens (human), Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, mRNA 3'-end processing, mRNA Capping, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, mRNA surveillance pathway - Homo sapiens (human), snRNP Assembly
UniProt: Q09161
Entrez ID: 4686
|
Does Knockout of RALB in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
RALB
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: RALB (RAS like proto-oncogene B)
Type: protein-coding
Summary: This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Ras protein signal transduction, apoptotic process, cell division, positive regulation of autophagosome assembly, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of innate immune response, receptor internalization, regulation of exocyst assembly, regulation of exocyst localization, signal transduction; MF: ATPase binding, G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding, ubiquitin protein ligase binding; CC: extracellular exosome, membrane, midbody, plasma membrane
Pathways: CXCR4-mediated signaling events, Chromosomal and microsatellite instability in colorectal cancer, Ciliary landscape, Colorectal cancer - Homo sapiens (human), EGF-EGFR signaling pathway, EGFR1, FoxO family signaling, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of p38-alpha and p38-beta, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, Signalling to ERKs, Signalling to RAS, p38MAPK events
UniProt: P11234
Entrez ID: 5899
|
Does Knockout of RNF128 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
RNF128
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: RNF128 (ring finger protein 128)
Type: protein-coding
Summary: The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: negative regulation of cytokine production, positive regulation of protein catabolic process in the vacuole, protein localization to lysosome, protein ubiquitination, regulation of protein stability, ubiquitin-dependent protein catabolic process; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytoskeleton, cytosol, endomembrane system, endoplasmic reticulum, late endosome, membrane, perinuclear region of cytoplasm
Pathways: Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Deubiquitination, Metabolism of proteins, Ovarian tumor domain proteases, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q8TEB7
Entrez ID: 79589
|
Does Knockout of ANAPC2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
ANAPC2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ANAPC2 (anaphase promoting complex subunit 2)
Type: protein-coding
Summary: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell differentiation, cell division, metaphase/anaphase transition of mitotic cell cycle, negative regulation of gene expression, nervous system development, positive regulation of axon extension, positive regulation of dendrite morphogenesis, positive regulation of synapse maturation, positive regulation of synaptic plasticity, proteasomal protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle, ubiquitin-dependent protein catabolic process; MF: protein binding, ubiquitin protein ligase binding; CC: anaphase-promoting complex, cullin-RING ubiquitin ligase complex, cytosol, nucleoplasm
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, Regulation of sister chromatid separation at the metaphase-anaphase transition, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9UJX6
Entrez ID: 29882
|
Does Knockout of FRMPD1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
FRMPD1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: FRMPD1 (FERM and PDZ domain containing 1)
Type: protein-coding
Summary: Involved in establishment of protein localization to membrane and regulation of G protein-coupled receptor signaling pathway. Located in plasma membrane. Part of protein-containing complex. Colocalizes with cell cortex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: establishment of protein localization, establishment of protein localization to membrane, light adaption, protein transport, regulation of G protein-coupled receptor signaling pathway, response to light intensity; CC: cell cortex, cytoplasm, cytosol, membrane, plasma membrane, protein-containing complex
Pathways:
UniProt: Q5SYB0
Entrez ID: 22844
|
Does Knockout of SLC18B1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
SLC18B1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: SLC18B1 (solute carrier family 18 member B1)
Type: protein-coding
Summary: This gene encodes a protein, which has high sequence similarity to rat, xenopus and zebrafish proteins. The protein function is unknown. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: polyamine transmembrane transport, proton transmembrane transport, serotonin uptake, spermidine transport, spermine transport, transmembrane transport; MF: monoamine:proton antiporter activity, polyamine:proton antiporter activity, transmembrane transporter activity; CC: cytoplasmic vesicle, membrane, secretory granule membrane, synapse, synaptic vesicle membrane, transport vesicle membrane
Pathways:
UniProt: Q6NT16
Entrez ID: 116843
|
Does Knockout of PET117 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
PET117
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: PET117 (PET117 cytochrome c oxidase chaperone)
Type: protein-coding
Summary: Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Implicated in cytochrome-c oxidase deficiency disease. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Mitochondrial CIV Assembly, Respiratory electron transport
UniProt: Q6UWS5
Entrez ID: 100303755
|
Does Activation of SERPINI2 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
SERPINI2
|
response to virus
|
Hepatoma Cell Line
|
Gene: SERPINI2 (serpin family I member 2)
Type: protein-coding
Summary: The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013].
Gene Ontology: MF: peptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity; CC: extracellular exosome, extracellular region, extracellular space
Pathways:
UniProt: O75830
Entrez ID: 5276
|
Does Knockout of DENND2D in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
DENND2D
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DENND2D (DENN domain containing 2D)
Type: protein-coding
Summary: Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, protein binding; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q9H6A0
Entrez ID: 79961
|
Does Knockout of SFRP2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
SFRP2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: SFRP2 (secreted frizzled related protein 2)
Type: protein-coding
Summary: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: BMP signaling pathway, Wnt signaling pathway, Wnt signaling pathway involved in somitogenesis, anterior/posterior pattern specification, apoptotic process, branching involved in blood vessel morphogenesis, canonical Wnt signaling pathway, cardiac left ventricle morphogenesis, cardiac muscle cell apoptotic process, cartilage development, cell differentiation, cell-cell signaling, cellular response to X-ray, chondrocyte development, collagen fibril organization, convergent extension involved in axis elongation, development of primary male sexual characteristics, digestive tract morphogenesis, embryonic digit morphogenesis, hematopoietic stem cell proliferation, male gonad development, mesodermal cell fate specification, negative regulation of BMP signaling pathway, negative regulation of DNA-templated transcription, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell growth, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of dermatome development, negative regulation of epithelial cell proliferation, negative regulation of epithelial to mesenchymal transition, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of gene expression, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of mesodermal cell fate specification, negative regulation of peptidyl-tyrosine phosphorylation, neural tube closure, neural tube development, non-canonical Wnt signaling pathway, outflow tract morphogenesis, positive regulation of angiogenesis, positive regulation of apoptotic process, positive regulation of canonical Wnt signaling pathway, positive regulation of cell adhesion mediated by integrin, positive regulation of cell growth, positive regulation of cell population proliferation, positive regulation of fat cell differentiation, positive regulation of osteoblast differentiation, positive regulation of transcription by RNA polymerase II, post-anal tail morphogenesis, regulation of Wnt signaling pathway, regulation of apoptotic process, regulation of cell growth, regulation of cell population proliferation, regulation of establishment of planar polarity, regulation of midbrain dopaminergic neuron differentiation, regulation of neuron projection development, regulation of stem cell division, response to nutrient, response to xenobiotic stimulus, sclerotome development, somitogenesis, stem cell fate specification; MF: Wnt-protein binding, endopeptidase activator activity, enzyme activator activity, fibronectin binding, integrin binding, receptor ligand activity; CC: extracellular matrix, extracellular region, extracellular space
Pathways: LncRNA involvement in canonical Wnt signaling and colorectal cancer, Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), ncRNAs involved in Wnt signaling in hepatocellular carcinoma
UniProt: Q96HF1
Entrez ID: 6423
|
Does Activation of KCNK9 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
KCNK9
|
response to virus
|
Hepatoma Cell Line
|
Gene: KCNK9 (potassium two pore domain channel subfamily K member 9)
Type: protein-coding
Summary: This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: cellular response to acidic pH, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of aldosterone secretion, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of action potential firing rate, regulation of resting membrane potential, sodium ion transmembrane transport, sodium ion transport, visual perception; MF: identical protein binding, metal ion binding, outward rectifier potassium channel activity, potassium channel activity, potassium ion leak channel activity, protein binding, protein heterodimerization activity, sodium channel activity, voltage-gated potassium channel activity; CC: cell projection, dendrite, membrane, mitochondrial inner membrane, mitochondrion, plasma membrane, synaptic vesicle
Pathways: Aldosterone synthesis and secretion - Homo sapiens (human), Cardiac conduction, Muscle contraction, Neuronal System, Nicotine Activity on Dopaminergic Neurons, Phase 4 - resting membrane potential, Potassium Channels, TWIK-releated acid-sensitive K+ channel (TASK), Tandem pore domain potassium channels
UniProt: Q9NPC2
Entrez ID: 51305
|
Does Knockout of SCTR in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
SCTR
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: SCTR (secretin receptor)
Type: protein-coding
Summary: The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, diet induced thermogenesis, intracellular water homeostasis, regulation of appetite, regulation of synaptic plasticity, response to nutrient levels, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, peptide hormone binding, secretin receptor activity, transmembrane signaling receptor activity; CC: basolateral plasma membrane, cytoplasmic microtubule, membrane, plasma membrane
Pathways: Bile secretion - Homo sapiens (human), Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class B Secretin-like, Glucagon-type ligand receptors, Neuroactive ligand-receptor interaction - Homo sapiens (human), Pancreatic secretion - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: P47872
Entrez ID: 6344
|
Does Knockout of WDR81 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
WDR81
|
response to virus
|
Hepatoma Cell Line
|
Gene: WDR81 (WD repeat domain 81)
Type: protein-coding
Summary: This gene encodes a multi-domain transmembrane protein which is predominantly expressed in the brain and is thought to play a role in endolysosomal trafficking. Mutations in this gene are associated with an autosomal recessive form of a syndrome exhibiting cerebellar ataxia, cognitive disability, and disequilibrium (CAMRQ2). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: aggrephagy, early endosome to late endosome transport, mitochondrion organization, protein stabilization, ubiquitin-dependent protein catabolic process; MF: K63-linked polyubiquitin modification-dependent protein binding, phosphatidylinositol 3-kinase inhibitor activity, phosphatidylinositol 3-kinase regulator activity, protein binding; CC: Golgi apparatus, autophagosome membrane, cytoplasm, cytoplasmic vesicle, cytosol, early endosome membrane, endoplasmic reticulum membrane, endosome, endosome membrane, late endosome membrane, lysosomal membrane, lysosome, membrane, mitochondrion
Pathways: CDC42 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q562E7
Entrez ID: 124997
|
Does Knockout of CAMK2B in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
CAMK2B
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: CAMK2B (calcium/calmodulin dependent protein kinase II beta)
Type: protein-coding
Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
Gene Ontology: BP: cell differentiation, long-term synaptic potentiation, nervous system development, positive regulation of dendritic spine morphogenesis, positive regulation of neuron projection development, positive regulation of synapse maturation, protein autophosphorylation, protein phosphorylation, regulation of calcium ion transport, regulation of dendritic spine development, regulation of long-term neuronal synaptic plasticity, regulation of neuron migration, regulation of neuronal synaptic plasticity, regulation of protein localization to plasma membrane, regulation of skeletal muscle adaptation, regulation of synapse structural plasticity, signal transduction; MF: ATP binding, actin binding, calcium/calmodulin-dependent protein kinase activity, calmodulin binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: calcium- and calmodulin-dependent protein kinase complex, centrosome, cytoplasm, cytoskeleton, cytosol, endocytic vesicle membrane, membrane, neuron projection, nucleoplasm, postsynaptic density, sarcoplasmic reticulum, sarcoplasmic reticulum membrane, synapse
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Amphetamine addiction - Homo sapiens (human), Axon guidance - Homo sapiens (human), Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Diabetic cardiomyopathy - Homo sapiens (human), Disruption of postsynaptic signaling by CNV, Dopaminergic synapse - Homo sapiens (human), ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), Fragile X Syndrome, Gastric acid secretion - Homo sapiens (human), Glioma - Homo sapiens (human), Glucagon signaling pathway - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), HIF-1 signaling pathway - Homo sapiens (human), IFN-gamma pathway, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), Melanogenesis - Homo sapiens (human), Myometrial relaxation and contraction pathways, NO-cGMP-PKG mediated Neuroprotection, Necroptosis - Homo sapiens (human), Neurotrophin signaling pathway - Homo sapiens (human), Non-genomic actions of 1,25 dihydroxyvitamin D3, Olfactory transduction - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Oxytocin signaling pathway - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Primary focal segmental glomerulosclerosis (FSGS), Proteoglycans in cancer - Homo sapiens (human), Regulation of Ras family activation, Renin-angiotensin-aldosterone system (RAAS), Serotonin and anxiety, Synaptic signaling pathways associated with autism spectrum disorder, Tuberculosis - Homo sapiens (human), Wnt signaling, Wnt signaling pathway - Homo sapiens (human), actions of nitric oxide in the heart, angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling, bcr signaling pathway, bioactive peptide induced signaling pathway, cAMP signaling pathway - Homo sapiens (human), ca-calmodulin-dependent protein kinase activation, calcium signaling by hbx of hepatitis b virus, control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk), corticosteroids and cardioprotection, effects of calcineurin in keratinocyte differentiation, endocytotic role of ndk phosphins and dynamin, fmlp induced chemokine gene expression in hmc-1 cells, ion channels and their functional role in vascular endothelium, links between pyk2 and map kinases, nfat and hypertrophy of the heart , nitric oxide signaling pathway, p38 MAPK signaling pathway, pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase, regulation of ck1/cdk5 by type 1 glutamate receptors, regulation of pgc-1a, role of mef2d in t-cell apoptosis, signal dependent regulation of myogenesis by corepressor mitr, signaling pathway from g-protein families, stathmin and breast cancer resistance to antimicrotubule agents, t cell receptor signaling pathway, transcription factor creb and its extracellular signals, vegf hypoxia and angiogenesis
UniProt: Q13554
Entrez ID: 816
|
Does Knockout of ZBTB14 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
ZBTB14
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: ZBTB14 (zinc finger and BTB domain containing 14)
Type: protein-coding
Summary: Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription, DNA-templated. Located in aggresome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cardiac septum development, coronary vasculature development, heart valve development, kidney development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: aggresome, cytosol, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: O43829
Entrez ID: 7541
|
Does Knockout of KCNC1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
KCNC1
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: KCNC1 (potassium voltage-gated channel subfamily C member 1)
Type: protein-coding
Summary: This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both 'b' and 'alpha', while the shorter isoform has been called both 'a' and 'beta' (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014].
Gene Ontology: BP: action potential, cellular response to xenobiotic stimulus, cerebellum development, corpus callosum development, globus pallidus development, monoatomic ion transmembrane transport, monoatomic ion transport, optic nerve development, positive regulation of monoatomic ion transmembrane transport, positive regulation of potassium ion transmembrane transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, protein tetramerization, regulation of monoatomic ion transmembrane transport, regulation of potassium ion transmembrane transport, regulation of presynaptic membrane potential, response to amine, response to auditory stimulus, response to fibroblast growth factor, response to light intensity, response to nerve growth factor, response to potassium ion, response to toxic substance, transmembrane transport; MF: delayed rectifier potassium channel activity, gated channel activity, kinesin binding, monoatomic ion channel activity, potassium channel activity, protein binding, transmembrane transporter binding, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, voltage-gated potassium channel activity; CC: axolemma, axon, axon terminus, calyx of Held, cell projection, cell surface, dendrite, dendrite membrane, membrane, monoatomic ion channel complex, neuron projection membrane, neuronal cell body, neuronal cell body membrane, plasma membrane, postsynaptic membrane, presynaptic membrane, synapse, voltage-gated potassium channel complex
Pathways: Fragile X Syndrome, Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: P48547
Entrez ID: 3746
|
Does Knockout of OR5C1 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
OR5C1
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: OR5C1 (olfactory receptor family 5 subfamily C member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGR4
Entrez ID: 392391
|
Does Knockout of TAS2R16 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
TAS2R16
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TAS2R16 (taste 2 receptor member 16)
Type: protein-coding
Summary: This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, protein binding; CC: endoplasmic reticulum, external side of plasma membrane, membrane, plasma membrane, trans-Golgi network
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Signal Transduction, Signaling by GPCR, Taste transduction - Homo sapiens (human)
UniProt: Q9NYV7
Entrez ID: 50833
|
Does Knockout of DDA1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
DDA1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: DDA1 (DET1 and DDB1 associated 1)
Type: protein-coding
Summary: Involved in protein polyubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of proteasomal ubiquitin-dependent protein catabolic process; CC: Cul4-RING E3 ubiquitin ligase complex, nucleoplasm
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9BW61
Entrez ID: 79016
|
Does Knockout of PLA2G7 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
PLA2G7
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: PLA2G7 (phospholipase A2 group VII)
Type: protein-coding
Summary: The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009].
Gene Ontology: BP: lipid catabolic process, lipid metabolic process, lipid oxidation, low-density lipoprotein particle remodeling, peptide hormone processing, phosphatidylcholine catabolic process, phospholipid catabolic process, plasma lipoprotein particle oxidation, platelet activating factor catabolic process, platelet activating factor metabolic process, positive regulation of inflammatory response, positive regulation of monocyte chemotaxis; MF: 1-alkyl-2-acetylglycerophosphocholine esterase activity, calcium-independent phospholipase A2 activity, hydrolase activity, hydrolase activity, acting on ester bonds, phospholipid binding, protein binding; CC: extracellular region, extracellular space, high-density lipoprotein particle, low-density lipoprotein particle
Pathways: Ether lipid metabolism - Homo sapiens (human), IL-18 signaling pathway, IL1 and megakaryocytes in obesity, Lissencephaly gene (LIS1) in neuronal migration and development, Metabolism of proteins, Peptide hormone metabolism, Synthesis, secretion, and deacylation of Ghrelin
UniProt: Q13093
Entrez ID: 7941
|
Does Knockout of NOC4L in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
NOC4L
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: NOC4L (nucleolar complex associated 4 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: rRNA processing, ribosome biogenesis; MF: RNA binding, protein binding; CC: Noc4p-Nop14p complex, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9BVI4
Entrez ID: 79050
|
Does Knockout of DOC2A in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
DOC2A
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: DOC2A (double C2 domain alpha)
Type: protein-coding
Summary: There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: calcium-dependent activation of synaptic vesicle fusion, chemical synaptic transmission, exocytosis, nervous system development, positive regulation of calcium ion-dependent exocytosis, regulation of calcium ion-dependent exocytosis, spontaneous neurotransmitter secretion, synaptic vesicle exocytosis; MF: calcium-dependent phospholipid binding, metal ion binding, protein binding; CC: cytoplasmic vesicle, extrinsic component of synaptic vesicle membrane, glutamatergic synapse, lysosome, membrane, neuron projection, synapse, synaptic vesicle membrane
Pathways: 16p11.2 proximal deletion syndrome
UniProt: Q14183
Entrez ID: 8448
|
Does Knockout of SPCS2 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
SPCS2
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: SPCS2 (signal peptidase complex subunit 2)
Type: protein-coding
Summary: Predicted to enable peptidase activity. Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein targeting to ER, signal peptide processing; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, signal peptidase complex
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Disease, Incretin synthesis, secretion, and inactivation, Infectious disease, Maturation of hRSV A proteins, Metabolism of proteins, Peptide hormone metabolism, Protein export - Homo sapiens (human), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) genome replication, transcription and translation, SRP-dependent cotranslational protein targeting to membrane, Synthesis, secretion, and deacylation of Ghrelin, Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), Translation, Viral Infection Pathways
UniProt: Q15005
Entrez ID: 9789
|
Does Knockout of NUP62 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
NUP62
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: NUP62 (nucleoporin 62)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA export from nucleus, cell surface receptor signaling pathway, cellular senescence, centriole assembly, centrosome cycle, mRNA transport, mitotic centrosome separation, mitotic metaphase chromosome alignment, negative regulation of Ras protein signal transduction, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of programmed cell death, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, positive regulation of canonical NF-kappaB signal transduction, positive regulation of centriole replication, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of mitotic cytokinetic process, positive regulation of mitotic nuclear division, positive regulation of protein localization to centrosome, protein import into nucleus, protein transport, regulation of Ras protein signal transduction, regulation of mitotic spindle organization, regulation of signal transduction; MF: Hsp70 protein binding, Hsp90 protein binding, PTB domain binding, SH2 domain binding, chromatin binding, phospholipid binding, protein binding, signaling receptor complex adaptor activity, structural constituent of nuclear pore, ubiquitin binding; CC: Flemming body, centrosome, cytoplasm, cytoskeleton, mitotic spindle, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore central transport channel, nucleoplasm, nucleus, ribonucleoprotein complex, spindle pole
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, snRNP Assembly, sumoylation by ranbp2 regulates transcriptional repression, tRNA processing, tRNA processing in the nucleus
UniProt: P37198
Entrez ID: 23636
|
Does Knockout of PALB2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
PALB2
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: PALB2 (partner and localizer of BRCA2)
Type: protein-coding
Summary: This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, animal organ morphogenesis, apoptotic process, double-strand break repair via homologous recombination, embryonic organ development, in utero embryonic development, inner cell mass cell proliferation, mesoderm development, multicellular organism growth, negative regulation of apoptotic process, post-anal tail morphogenesis, somitogenesis; MF: DNA binding, protein binding; CC: DNA repair complex, nuclear speck, nucleoplasm, nucleus, protein-containing complex
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Defective homologous recombination repair (HRR) due to BRCA1 loss of function, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Defective homologous recombination repair (HRR) due to PALB2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Fanconi anemia pathway, Fanconi anemia pathway - Homo sapiens (human), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to PALB2, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Post-translational protein modification, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
UniProt: Q86YC2
Entrez ID: 79728
|
Does Knockout of NAPA in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
NAPA
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: NAPA (NSF attachment protein alpha)
Type: protein-coding
Summary: This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: SNARE complex disassembly, apical protein localization, brain development, intra-Golgi vesicle-mediated transport, intracellular protein transport, membrane fusion, neuron differentiation, protein transport, protein-containing complex disassembly, regulation of synaptic vesicle priming, synaptic transmission, glutamatergic, synaptic vesicle priming, vesicle-mediated transport; MF: SNARE binding, protein binding, protein-containing complex binding, soluble NSF attachment protein activity, syntaxin binding; CC: cytosol, extracellular exosome, glutamatergic synapse, membrane, neuromuscular junction, plasma membrane, postsynapse, presynapse, presynaptic active zone membrane, synaptobrevin 2-SNAP-25-syntaxin-1a complex
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Golgi Associated Vesicle Biogenesis, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Synaptic Vesicle Pathway, Synaptic vesicle cycle - Homo sapiens (human), Transport to the Golgi and subsequent modification, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: P54920
Entrez ID: 8775
|
Does Knockout of DMAP1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
DMAP1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: DMAP1 (DNA methyltransferase 1 associated protein 1)
Type: protein-coding
Summary: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of protein import into nucleus, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, response to ethanol; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, transcription corepressor activity; CC: NuA4 histone acetyltransferase complex, Swr1 complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleosome, nucleus, replication fork
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9NPF5
Entrez ID: 55929
|
Does Knockout of MID2 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
MID2
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: MID2 (midline 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009].
Gene Ontology: BP: host-mediated suppression of symbiont invasion, innate immune response, negative regulation of viral transcription, positive regulation of DNA-templated transcription, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of intracellular signal transduction, protein localization to microtubule, protein ubiquitination, suppression of viral release by host; MF: enzyme binding, identical protein binding, metal ion binding, microtubule binding, phosphoprotein binding, protein binding, protein homodimerization activity, transcription coactivator activity, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytoskeleton, extracellular exosome, microtubule
Pathways:
UniProt: Q9UJV3
Entrez ID: 11043
|
Does Knockout of PSMA1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
PSMA1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: PSMA1 (proteasome 20S subunit alpha 1)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009].
Gene Ontology: BP: immune system process, negative regulation of inflammatory response to antigenic stimulus, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: lipopolysaccharide binding, protein binding; CC: centrosome, cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), proteasome complex
UniProt: P25786
Entrez ID: 5682
|
Does Knockout of FAM171B in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
FAM171B
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: FAM171B (family with sequence similarity 171 member B)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, synapse
Pathways:
UniProt: Q6P995
Entrez ID: 165215
|
Does Knockout of HMGB1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
HMGB1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: HMGB1 (high mobility group box 1)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: DNA damage response, DNA geometric change, DNA metabolic process, DNA recombination, DNA repair, DNA topological change, T-helper 1 cell activation, T-helper 1 cell differentiation, V(D)J recombination, activation of innate immune response, adaptive immune response, apoptotic cell clearance, autophagy, base-excision repair, cell development, cellular response to interleukin-7, cellular response to lipopolysaccharide, chemotaxis, chromatin organization, chromatin remodeling, dendritic cell chemotaxis, double-strand break repair, double-strand break repair via nonhomologous end joining, endothelial cell chemotaxis, endothelial cell proliferation, eye development, glycogen catabolic process, heterochromatin formation, immune response, immune system process, inflammatory response, inflammatory response to antigenic stimulus, innate immune response, lung development, macrophage activation involved in immune response, myeloid cell differentiation, myeloid dendritic cell activation, myeloid progenitor cell differentiation, negative regulation of CD4-positive, alpha-beta T cell differentiation, negative regulation of RNA polymerase II transcription preinitiation complex assembly, negative regulation of apoptotic cell clearance, negative regulation of blood vessel endothelial cell migration, negative regulation of endothelial cell migration, negative regulation of transcription by RNA polymerase II, negative regulation of type II interferon production, neuron projection development, neutrophil clearance, plasmacytoid dendritic cell activation, positive chemotaxis, positive regulation of DNA binding, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of activated T cell proliferation, positive regulation of apoptotic process, positive regulation of autophagy, positive regulation of blood vessel endothelial cell migration, positive regulation of cell differentiation, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of chemokine production, positive regulation of cytosolic calcium ion concentration, positive regulation of dendritic cell differentiation, positive regulation of endothelial cell proliferation, positive regulation of glycogen catabolic process, positive regulation of innate immune response, positive regulation of interferon-alpha production, positive regulation of interferon-beta production, positive regulation of interleukin-1 beta production, positive regulation of interleukin-1 production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of mismatch repair, positive regulation of monocyte chemotactic protein-1 production, positive regulation of monocyte chemotaxis, positive regulation of myeloid cell differentiation, positive regulation of myeloid progenitor cell differentiation, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of sprouting angiogenesis, positive regulation of toll-like receptor 2 signaling pathway, positive regulation of toll-like receptor 4 signaling pathway, positive regulation of toll-like receptor 9 signaling pathway, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of vascular endothelial cell proliferation, positive regulation of viral entry into host cell, positive regulation of wound healing, regulation of DNA metabolic process, regulation of T cell mediated immune response to tumor cell, regulation of hemopoiesis, regulation of nucleotide-excision repair, regulation of restriction endodeoxyribonuclease activity, regulation of tolerance induction, regulation of viral process, response to glucocorticoid, signal transduction, transcription by RNA polymerase II; MF: C-X-C chemokine binding, DNA binding, DNA binding, bending, DNA polymerase binding, DNA-binding transcription factor binding, RAGE receptor binding, RNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, bubble DNA binding, calcium-dependent protein kinase regulator activity, chemoattractant activity, cytokine activity, damaged DNA binding, double-stranded DNA binding, double-stranded RNA binding, four-way junction DNA binding, integrin binding, lipid binding, lipopolysaccharide binding, lyase activity, phosphatidylserine binding, protein binding, protein kinase activator activity, receptor ligand activity, single-stranded DNA binding, single-stranded RNA binding, supercoiled DNA binding, transcription cis-regulatory region binding, transcription coactivator activity, transcription corepressor activity; CC: alphav-beta3 integrin-HMGB1 complex, cell surface, chromosome, condensed chromosome, cytoplasm, early endosome, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, endosome, extracellular region, extracellular space, ficolin-1-rich granule lumen, membrane, neuron projection, nucleoplasm, nucleus, plasma membrane, secretory granule lumen, transcription repressor complex
Pathways: Adaptive Immune System, Advanced glycosylation endproduct receptor signaling, Antigen processing-Cross presentation, Apoptosis, Apoptosis induced DNA fragmentation, Apoptotic execution phase, Autophagy - animal - Homo sapiens (human), Base Excision Repair, Base excision repair - Homo sapiens (human), Beta3 integrin cell surface interactions, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, DDX58/IFIH1-mediated induction of interferon-alpha/beta, DNA Repair Pathways Full Network, DNA damage response (only ATM dependent), Disease, Diseases associated with the TLR signaling cascade, Diseases of Immune System, ER-Phagosome pathway, Endogenous TLR signaling, IRAK4 deficiency (TLR2/4), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, MyD88 cascade initiated on plasma membrane, MyD88 deficiency (TLR2/4), MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Necroptosis - Homo sapiens (human), Neutrophil degranulation, Neutrophil extracellular trap formation - Homo sapiens (human), Programmed Cell Death, Pyroptosis, Regulated Necrosis, Regulation of TLR by endogenous ligand, Retinoblastoma gene in cancer, Signaling by Interleukins, Supression of HMGB1 mediated inflammation by THBD, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated NF-kB activation, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, VEGFA-VEGFR2 Signaling Pathway, amb2 Integrin signaling, apoptotic dna-fragmentation and tissue homeostasis, the information processing pathway at the ifn beta enhancer
UniProt: P09429
Entrez ID: 3146
|
Does Knockout of OR10G2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
OR10G2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: OR10G2 (olfactory receptor family 10 subfamily G member 2)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGC3
Entrez ID: 26534
|
Does Knockout of MINDY2 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
MINDY2
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: MINDY2 (MINDY lysine 48 deubiquitinase 2)
Type: protein-coding
Summary: Enables cysteine-type peptidase activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in protein K48-linked deubiquitination. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: K11-linked polyubiquitin modification-dependent protein binding, K48-linked deubiquitinase activity, K48-linked polyubiquitin modification-dependent protein binding, K6-linked polyubiquitin modification-dependent protein binding, K63-linked polyubiquitin modification-dependent protein binding, cysteine-type carboxypeptidase activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: cell periphery, nucleoplasm
Pathways:
UniProt: Q8NBR6
Entrez ID: 54629
|
Does Knockout of ADAM10 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
ADAM10
|
cell proliferation
|
Cancer Cell Line
|
Gene: ADAM10 (ADAM metallopeptidase domain 10)
Type: protein-coding
Summary: Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: Notch signaling pathway, adherens junction organization, amyloid precursor protein catabolic process, cell-cell signaling, cochlea development, constitutive protein ectodomain proteolysis, epidermal growth factor receptor ligand maturation, extracellular matrix disassembly, in utero embryonic development, integrin-mediated signaling pathway, membrane protein ectodomain proteolysis, monocyte activation, negative regulation of cell adhesion, negative regulation of gene expression, pore complex assembly, positive regulation of T cell chemotaxis, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of tumor necrosis factor production, positive regulation of tumor necrosis factor-mediated signaling pathway, postsynapse organization, protein catabolic process at postsynapse, protein processing, proteolysis, regulation of Notch signaling pathway, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, regulation of postsynapse organization, regulation of vasculature development, response to tumor necrosis factor, signaling receptor ligand precursor processing; MF: SH3 domain binding, endopeptidase activity, hydrolase activity, integrin binding, metal ion binding, metallodipeptidase activity, metalloendopeptidase activity, metalloendopeptidase activity involved in amyloid precursor protein catabolic process, metallopeptidase activity, peptidase activity, protein binding, protein homodimerization activity, protein kinase binding; CC: Golgi apparatus, Golgi membrane, Golgi-associated vesicle, adherens junction, anchoring junction, axon, cell projection, cell surface, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, dendrite, endoplasmic reticulum lumen, extracellular exosome, focal adhesion, glutamatergic synapse, membrane, nucleus, perinuclear endoplasmic reticulum, plasma membrane, pore complex, postsynaptic density, specific granule membrane, synaptic membrane, tertiary granule membrane, tetraspanin-enriched microdomain
Pathways: 3q29 copy number variation syndrome, Activated NOTCH1 Transmits Signal to the Nucleus, Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amyloid fiber formation, Axon guidance, Canonical and non-canonical Notch signaling, Collagen degradation, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, Copper homeostasis, Degradation of the extracellular matrix, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Extracellular matrix organization, Hypertrophy Model, Immune System, Innate Immune System, Metabolism of proteins, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, NOTCH4 Activation and Transmission of Signal to the Nucleus, Nervous system development, Neutrophil degranulation, Notch signaling pathway, Post-translational protein modification, Post-translational protein phosphorylation, Posttranslational regulation of adherens junction stability and dissassembly, Presenilin action in Notch and Wnt signaling, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Signal Transduction, Signaling by EGFR, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD Domain Mutants in Cancer, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by NOTCH4, Signaling by Receptor Tyrosine Kinases, VEGFA-VEGFR2 Signaling Pathway, generation of amyloid b-peptide by ps1
UniProt: O14672
Entrez ID: 102
|
Does Knockout of SCN11A in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
SCN11A
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: SCN11A (sodium voltage-gated channel alpha subunit 11)
Type: protein-coding
Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, action potential, action potential initiation, acute inflammatory response, artery development, axonogenesis, behavioral response to acetic acid induced pain, behavioral response to formalin induced pain, behavioral response to pain, cAMP/PKA signal transduction, calcitonin gene-related peptide receptor signaling pathway, calcium ion transmembrane transport, cardiac muscle cell action potential involved in contraction, cell motility, cellular response to cold, chemosensory behavior, chronic inflammatory response, circadian rhythm, detection of mechanical stimulus involved in sensory perception, detection of mechanical stimulus involved in sensory perception of pain, detection of temperature stimulus involved in sensory perception of pain, establishment of localization in cell, inflammatory response, mast cell degranulation, membrane depolarization during action potential, micturition, monoatomic ion transmembrane transport, monoatomic ion transport, neuronal action potential, reflex, regulation of membrane potential, response to auditory stimulus, response to cold, response to heat, response to high light intensity, response to nitric oxide, response to pain, response to prostaglandin E, response to toxic substance, response to xenobiotic stimulus, sensory perception of itch, sensory perception of pain, skeletal muscle organ development, small intestine smooth muscle contraction, sodium ion transmembrane transport, sodium ion transport, thermosensory behavior, thigmotaxis, transmembrane transport, transmission of nerve impulse; MF: monoatomic cation channel activity, monoatomic ion channel activity, sodium channel activity, voltage-gated sodium channel activity; CC: C-fiber, axon, axonal growth cone, cell body, extracellular exosome, membrane, monoatomic ion channel complex, neuronal cell body, plasma membrane, voltage-gated sodium channel complex
Pathways: Axon guidance, Cardiac conduction, Developmental Biology, Interaction between L1 and Ankyrins, L1CAM interactions, Muscle contraction, Nervous system development, Phase 0 - rapid depolarisation
UniProt: Q9UI33
Entrez ID: 11280
|
Does Knockout of TSACC in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
TSACC
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: TSACC (TSSK6 activating cochaperone)
Type: protein-coding
Summary: Enables chaperone binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, protein-folding chaperone binding; CC: cytoplasm
Pathways:
UniProt: Q96A04
Entrez ID: 128229
|
Does Knockout of RPL15 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
RPL15
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RPL15 (ribosomal protein L15)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, cadherin binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, nucleus, ribonucleoprotein complex, ribosomal subunit, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P61313
Entrez ID: 6138
|
Does Knockout of NXF5 in Glioma Cell Line causally result in protein/peptide accumulation?
| 0
| 589
|
Knockout
|
NXF5
|
protein/peptide accumulation
|
Glioma Cell Line
|
Gene: NXF5 (nuclear RNA export factor 5)
Type: pseudo
Summary: This gene is one member of a family of nuclear RNA export factor genes. Most transcript variants are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo. [provided by RefSeq, Sep 2022].
Gene Ontology: BP: RNA transport, mRNA export from nucleus, mRNA transport, poly(A)+ mRNA export from nucleus; MF: RNA binding, nucleic acid binding, protein binding; CC: cytoplasm, nuclear RNA export factor complex, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Influenza A - Homo sapiens (human), RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt:
Entrez ID: 55998
|
Does Knockout of ZNF586 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
ZNF586
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: ZNF586 (zinc finger protein 586)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q9NXT0
Entrez ID: 54807
|
Does Knockout of ATP6V1A in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
ATP6V1A
|
cell proliferation
|
Cancer Cell Line
|
Gene: ATP6V1A (ATPase H+ transporting V1 subunit A)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ATP metabolic process, Golgi lumen acidification, cellular response to increased oxygen levels, endosomal lumen acidification, homeostatic process, intracellular iron ion homeostasis, intracellular pH reduction, lysosomal lumen acidification, monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification, vacuolar acidification; MF: ATP binding, ATP hydrolysis activity, nucleotide binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: ATPase complex, Golgi membrane, apical plasma membrane, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytosol, endosome membrane, extracellular exosome, extrinsic component of synaptic vesicle membrane, lysosomal membrane, lysosome, membrane, microvillus, nucleoplasm, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, proton-transporting two-sector ATPase complex, secretory granule, transport vesicle, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, mTOR signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: P38606
Entrez ID: 523
|
Does Knockout of RSPH14 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
RSPH14
|
cell proliferation
|
Cancer Cell Line
|
Gene: RSPH14 (radial spoke head 14 homolog)
Type: protein-coding
Summary: This gene encodes a protein with no known function but with slight similarity to a yeast vacuolar protein. The gene is located in a region deleted in pediatric rhabdoid tumors of the brain, kidney and soft tissues, but mutations in this gene have not been associated with the disease. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: cell projection, cilium, cytoplasm, cytoskeleton, motile cilium, radial spoke
Pathways:
UniProt: Q9UHP6
Entrez ID: 27156
|
Does Knockout of OR9Q1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
OR9Q1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: OR9Q1 (olfactory receptor family 9 subfamily Q member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGQ5
Entrez ID: 219956
|
Does Knockout of CTBP2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
CTBP2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CTBP2 (C-terminal binding protein 2)
Type: protein-coding
Summary: This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, positive regulation of retinoic acid receptor signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, viral genome replication, white fat cell differentiation; MF: DNA-binding transcription factor binding, NAD binding, identical protein binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein binding, protein kinase binding, protein-containing complex binding, transcription coactivator activity, transcription coregulator binding, transcription corepressor activity, transcription corepressor binding; CC: nucleus, synapse, transcription repressor complex
Pathways: Chronic myeloid leukemia - Homo sapiens (human), Ciliary landscape, LncRNA involvement in canonical Wnt signaling and colorectal cancer, Mesodermal commitment pathway, Neural Crest Differentiation, Notch Signaling, Notch signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Wnt signaling, Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, ncRNAs involved in Wnt signaling in hepatocellular carcinoma
UniProt: P56545
Entrez ID: 1488
|
Does Knockout of CHAF1A in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
CHAF1A
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CHAF1A (chromatin assembly factor 1 subunit A)
Type: protein-coding
Summary: Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin assembly, chromatin organization, nucleosome assembly; MF: chromatin binding, chromo shadow domain binding, identical protein binding, protein binding, unfolded protein binding; CC: CAF-1 complex, chromatin, nucleus, protein-containing complex
Pathways: Nanoparticle triggered autophagic cell death, btg family proteins and cell cycle regulation
UniProt: Q13111
Entrez ID: 10036
|
Does Knockout of GTF3C1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
GTF3C1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GTF3C1 (general transcription factor IIIC subunit 1)
Type: protein-coding
Summary: Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation from RNA polymerase III promoter. Located in nucleolus and nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 5S class rRNA transcription by RNA polymerase III, rRNA transcription, tRNA transcription, tRNA transcription by RNA polymerase III, transcription by RNA polymerase III, transcription initiation at RNA polymerase III promoter; MF: DNA binding, RNA polymerase III general transcription initiation factor activity, protein binding; CC: membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, transcription factor TFIIIC complex
Pathways: Gene expression (Transcription), RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, rna polymerase iii transcription
UniProt: Q12789
Entrez ID: 2975
|
Does Knockout of RPL39L in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
RPL39L
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RPL39L (ribosomal protein L39 like)
Type: protein-coding
Summary: This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: spermatogenesis, translation; MF: protein binding, structural constituent of ribosome; CC: cytoplasm, cytosolic large ribosomal subunit, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q96EH5
Entrez ID: 116832
|
Does Knockout of CASP7 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
CASP7
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: CASP7 (caspase 7)
Type: protein-coding
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: apoptotic process, cellular response to lipopolysaccharide, cellular response to staurosporine, ceramide biosynthetic process, defense response to bacterium, execution phase of apoptosis, fibroblast apoptotic process, heart development, leukocyte apoptotic process, lymphocyte apoptotic process, negative regulation of transcription by RNA polymerase II, neuron apoptotic process, plasma membrane repair, positive regulation of canonical NF-kappaB signal transduction, positive regulation of neuron apoptotic process, positive regulation of plasma membrane repair, protein catabolic process, protein maturation, protein poly-ADP-ribosylation, protein processing, proteolysis, pyroptotic inflammatory response, regulation of transcription by RNA polymerase II, response to UV, striated muscle cell differentiation; MF: RNA binding, aspartic-type endopeptidase activity, catalytic activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding; CC: cytoplasm, cytosol, extracellular region, extracellular space, fibrillar center, nucleoplasm, nucleus, plasma membrane
Pathways: 3q29 copy number variation syndrome, 5-Oxoprolinuria, 5-oxoprolinase deficiency, Acute viral myocarditis, Allograft Rejection, Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, AndrogenReceptor, Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis - multiple species - Homo sapiens (human), Apoptosis Modulation and Signaling, Apoptosis Modulation by HSP70, Apoptosis-related network due to altered Notch3 in ovarian cancer, BCR, Caspase Cascade in Apoptosis, E2F transcription factor network, ERK Pathway in Huntington,s Disease, Fas ligand pathway and stress induction of heat shock proteins, Gamma-Glutamyltransferase Deficiency, Gamma-glutamyl-transpeptidase deficiency, Glutathione Metabolism, Glutathione Synthetase Deficiency, HIV-1 Nef: Negative effector of Fas and TNF-alpha, Hepatitis C and Hepatocellular Carcinoma, Host-pathogen interaction of human coronaviruses - apoptosis, Legionellosis - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Nanomaterial induced apoptosis, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Nucleotide-binding Oligomerization Domain (NOD) pathway, Oncostatin M Signaling Pathway, Parkinson,s disease pathway, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Pertussis - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, Salmonella infection - Homo sapiens (human), TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, TNF signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, TNFalpha, a6b1 and a6b4 Integrin signaling, apoptotic dna-fragmentation and tissue homeostasis, apoptotic signaling in response to dna damage, b cell survival pathway, caspase cascade in apoptosis, fas signaling pathway (cd95), hiv-1 nef: negative effector of fas and tnf, induction of apoptosis through dr3 and dr4/5 death receptors, internal ribosome entry pathway, regulation of cell cycle progression by plk3, trefoil factors initiate mucosal healing, west nile virus
UniProt: P55210
Entrez ID: 840
|
Does Knockout of TUBA1B in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
TUBA1B
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: TUBA1B (tubulin alpha 1b)
Type: protein-coding
Summary: Enables double-stranded RNA binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within cellular response to interleukin-4. Located in microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, cellular response to interleukin-4, cytoskeleton-dependent intracellular transport, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, GTPase activity, double-stranded RNA binding, hydrolase activity, nucleotide binding, protein binding, structural constituent of cytoskeleton, structural molecule activity, ubiquitin protein ligase binding; CC: cilium, cytoplasm, cytoplasmic microtubule, cytoskeleton, microtubule, microtubule cytoskeleton
Pathways: Activation of AMPK downstream of NMDARs, Activation of NMDA receptors and postsynaptic events, Adaptive Immune System, Aggrephagy, Allograft Rejection, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Apoptosis - Homo sapiens (human), Asparagine N-linked glycosylation, Assembly and cell surface presentation of NMDA receptors, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Chaperonin-mediated protein folding, Cilium Assembly, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Cytokine Signaling in Immune system, Developmental Biology, Disease, Docetaxel Action Pathway, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, Formation of tubulin folding intermediates by CCT/TriC, G2/M Transition, Gap junction - Homo sapiens (human), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HCMV Early Events, HCMV Infection, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hedgehog 'off' state, Hemostasis, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, L1CAM interactions, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Paclitaxel Action Pathway, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phagosome - Homo sapiens (human), Post NMDA receptor activation events, Post-chaperonin tubulin folding pathway, Post-translational protein modification, Prion disease - Homo sapiens (human), Protein folding, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, RHOH GTPase cycle, Recruitment of NuMA to mitotic centrosomes, Recycling pathway of L1, Resolution of Sister Chromatid Cohesion, Salmonella infection - Homo sapiens (human), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling events mediated by HDAC Class II, Signaling events mediated by HDAC Class III, Signaling events mediated by PRL, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, Transmission across Chemical Synapses, Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, Vinblastine Action Pathway, Vincristine Action Pathway, Vindesine Action Pathway, Vinorelbine Action Pathway, Viral Infection Pathways
UniProt: P68363
Entrez ID: 10376
|
Does Knockout of CTCF in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
CTCF
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CTCF (CCCTC-binding factor)
Type: protein-coding
Summary: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cardiac muscle cell development, cardiac muscle cell differentiation, chromatin looping, chromatin organization, chromosome segregation, epigenetic regulation of gene expression, gene expression, genomic imprinting, heart development, in utero embryonic development, mitochondrion organization, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, protein localization to chromosome, protein localization to chromosome, centromeric region, regulation of DNA-templated transcription, regulation of centromeric sister chromatid cohesion, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, chromatin insulator sequence binding, chromatin loop anchoring activity, cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coregulator binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, male germ cell nucleus, nucleolus, nucleoplasm, nucleus
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Developmental Biology, MECP2 and Associated Rett Syndrome, Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors, Prion disease pathway, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, TGF_beta_Receptor, ctcf: first multivalent nuclear factor
UniProt: P49711
Entrez ID: 10664
|
Does Knockout of RNF103 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
RNF103
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: RNF103 (ring finger protein 103)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: ERAD pathway, central nervous system development, endoplasmic reticulum mannose trimming, protein ubiquitination; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, membrane
Pathways: Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, ER Quality Control Compartment (ERQC), Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Post-translational protein modification
UniProt: O00237
Entrez ID: 7844
|
Does Activation of PPIAL4G in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
PPIAL4G
|
response to virus
|
Hepatoma Cell Line
|
Gene: PPIAL4G (peptidylprolyl isomerase A like 4G)
Type: protein-coding
Summary: Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein folding; MF: cyclosporin A binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity; CC: cytoplasm
Pathways:
UniProt: P0DN37
Entrez ID: 644591
|
Does Knockout of PROSER3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
PROSER3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PROSER3 (proline and serine rich 3)
Type: protein-coding
Summary: Located in centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: centrosome, cytoplasm, cytoskeleton
Pathways:
UniProt: Q2NL68
Entrez ID: 148137
|
Does Knockout of FAF2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
FAF2
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: FAF2 (Fas associated factor family member 2)
Type: protein-coding
Summary: The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ERAD pathway, lipid droplet organization, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, response to unfolded protein, retrograde protein transport, ER to cytosol, stress granule disassembly; MF: lipase binding, lipase inhibitor activity, protein binding, protein-macromolecule adaptor activity, ubiquitin binding, ubiquitin protein ligase binding; CC: VCP-NPL4-UFD1 AAA ATPase complex, azurophil granule lumen, cytoplasm, endoplasmic reticulum, extracellular region, lipid droplet
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q96CS3
Entrez ID: 23197
|
Does Knockout of ZNF578 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
ZNF578
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: ZNF578 (zinc finger protein 578)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, nucleus
Pathways: Herpes simplex virus 1 infection - Homo sapiens (human)
UniProt: Q96N58
Entrez ID: 147660
|
Does Knockout of CENPE in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
CENPE
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CENPE (centromere protein E)
Type: protein-coding
Summary: Centrosome-associated protein E (CENPE) is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. This protein is required for stable spindle microtubule capture at kinetochores which is a necessary step in chromosome alignment during prometaphase. This protein also couples chromosome position to microtubule depolymerizing activity. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore assembly, lateral attachment of mitotic spindle microtubules to kinetochore, membraneless organelle assembly, metaphase chromosome alignment, microtubule plus-end directed mitotic chromosome migration, microtubule-based movement, mitotic cell cycle, mitotic chromosome movement towards spindle pole, mitotic metaphase chromosome alignment, mitotic spindle organization, nuclear division, positive regulation of protein kinase activity, regulation of mitotic metaphase/anaphase transition, spindle organization; MF: ATP binding, kinetochore binding, microtubule binding, microtubule motor activity, nucleotide binding, protein binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, intercellular bridge, kinetochore, kinetochore microtubule, membrane, microtubule, microtubule cytoskeleton, midbody, mitotic spindle, mitotic spindle midzone, nucleus, spindle, spindle midzone
Pathways: Adaptive Immune System, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, COPI-dependent Golgi-to-ER retrograde traffic, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, Factors involved in megakaryocyte development and platelet production, Genotoxicity pathway, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, M Phase, MHC class II antigen presentation, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, PLK1 signaling events, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of sister chromatid separation at the metaphase-anaphase transition, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: Q02224
Entrez ID: 1062
|
Does Knockout of NUP160 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
NUP160
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: NUP160 (nucleoporin 160)
Type: protein-coding
Summary: NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM, Apr 2004]
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, nephron development, nucleocytoplasmic transport, protein transport; MF: protein binding, structural constituent of nuclear pore; CC: cytosol, kinetochore, nuclear envelope, nuclear pore, nuclear pore outer ring, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, EML4 and NUDC in mitotic spindle formation, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q12769
Entrez ID: 23279
|
Does Knockout of LAMTOR4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
LAMTOR4
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: LAMTOR4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4)
Type: protein-coding
Summary: Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cellular response to amino acid stimulus; positive regulation of TOR signaling; and protein localization to lysosome. Located in lysosome. Part of Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: TORC1 signaling, cellular response to amino acid stimulus, positive regulation of TOR signaling, positive regulation of TORC1 signaling, protein localization to lysosome, regulation of cell size; MF: guanyl-nucleotide exchange factor activity, molecular adaptor activity, protein binding; CC: FNIP-folliculin RagC/D GAP, Ragulator complex, late endosome membrane, lysosomal membrane, lysosome
Pathways: Amino acids regulate mTORC1, Autophagy, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, MTOR signalling, Macroautophagy, PIP3 activates AKT signaling, PTEN Regulation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Signal Transduction, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, mTOR signaling pathway - Homo sapiens (human), mTORC1-mediated signalling
UniProt: Q0VGL1
Entrez ID: 389541
|
Does Knockout of FDPS in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
FDPS
|
cell proliferation
|
Cancer Cell Line
|
Gene: FDPS (farnesyl diphosphate synthase)
Type: protein-coding
Summary: This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008].
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol metabolic process, farnesyl diphosphate biosynthetic process, geranyl diphosphate biosynthetic process, isoprenoid biosynthetic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: (2E,6E)-farnesyl diphosphate synthase activity, RNA binding, dimethylallyltranstransferase activity, metal ion binding, prenyltransferase activity, protein binding, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: cytoplasm, cytosol, mitochondrial matrix, nucleoplasm, peroxisome
Pathways: <i>trans, trans</i>-farnesyl diphosphate biosynthesis, Activation of gene expression by SREBF (SREBP), Alendronate Action Pathway, Atorvastatin Action Pathway, CHILD Syndrome, Cerivastatin Action Pathway, Cholesterol Biosynthesis Pathway, Cholesterol biosynthesis, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Cholesteryl ester storage disease, Chondrodysplasia Punctata II, X Linked Dominant (CDPX2), Desmosterolosis, Fluvastatin Action Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Hyper-IgD syndrome, Hypercholesterolemia, Ibandronate Action Pathway, Influenza A - Homo sapiens (human), Lovastatin Action Pathway, Lysosomal Acid Lipase Deficiency (Wolman Disease), Metabolism, Metabolism of lipids, Metabolism of steroids, Mevalonic aciduria, Pamidronate Action Pathway, Pravastatin Action Pathway, Regulation of cholesterol biosynthesis by SREBP (SREBF), Risedronate Action Pathway, Rosuvastatin Action Pathway, Simvastatin Action Pathway, Smith-Lemli-Opitz Syndrome (SLOS), Steroid Biosynthesis, Sterol regulatory element-binding proteins (SREBP) signaling, Terpenoid backbone biosynthesis - Homo sapiens (human), Wolman disease, Zoledronate Action Pathway, superpathway of cholesterol biosynthesis, superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
UniProt: P14324
Entrez ID: 2224
|
Does Knockout of SREK1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
SREK1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SREK1 (splicing regulatory glutamic acid and lysine rich protein 1)
Type: protein-coding
Summary: This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: RNA splicing, mRNA processing; MF: RNA binding, nucleic acid binding, protein binding; CC: nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: mRNA Processing
UniProt: Q8WXA9
Entrez ID: 140890
|
Does Knockout of OR6M1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
OR6M1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: OR6M1 (olfactory receptor family 6 subfamily M member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGM8
Entrez ID: 390261
|
Does Knockout of SLC4A5 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
SLC4A5
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: SLC4A5 (solute carrier family 4 member 5)
Type: protein-coding
Summary: This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: bicarbonate transport, cerebrospinal fluid secretion, epithelial cell development, inorganic anion transport, mitochondrion distribution, monoatomic anion transmembrane transport, monoatomic anion transport, monoatomic ion transport, regulation of gene expression, regulation of intracellular pH, regulation of systemic arterial blood pressure, renal system process, retina development in camera-type eye, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: antiporter activity, bicarbonate transmembrane transporter activity, monoatomic anion transmembrane transporter activity, sodium:bicarbonate symporter activity, solute:inorganic anion antiporter activity, solute:sodium symporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, plasma membrane
Pathways: Bicarbonate transporters, Bile secretion - Homo sapiens (human), SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Transport of small molecules
UniProt: Q9BY07
Entrez ID: 57835
|
Does Knockout of NEO1 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
NEO1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: NEO1 (neogenin 1)
Type: protein-coding
Summary: This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
Gene Ontology: BP: axon guidance, cell adhesion, cell-cell adhesion, intracellular iron ion homeostasis, multicellular organismal-level iron ion homeostasis, myoblast fusion, negative regulation of axon regeneration, negative regulation of protein secretion, neuron migration, positive regulation of BMP signaling pathway, protein secretion, regulation of DNA-templated transcription, regulation of axon regeneration, trans-synaptic signaling, modulating synaptic transmission; MF: BMP receptor binding, cadherin binding, co-receptor binding, protein binding, signaling receptor activity; CC: Golgi apparatus, cell surface, glutamatergic synapse, growth cone, intracellular vesicle, membrane, nucleoplasm, plasma membrane, plasma membrane protein complex, postsynaptic density membrane
Pathways: Axon guidance, Axon guidance - Homo sapiens (human), Cell adhesion molecules - Homo sapiens (human), Developmental Biology, Myogenesis, Nervous system development, Netrin-1 signaling, Netrin-UNC5B signaling pathway, Splicing factor NOVA regulated synaptic proteins, TGF-beta signaling pathway - Homo sapiens (human)
UniProt: Q92859
Entrez ID: 4756
|
Does Knockout of SPTLC1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
SPTLC1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: SPTLC1 (serine palmitoyltransferase long chain base subunit 1)
Type: protein-coding
Summary: This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: amide biosynthetic process, ceramide biosynthetic process, lipid metabolic process, positive regulation of lipophagy, regulation of fat cell apoptotic process, sphinganine biosynthetic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingomyelin biosynthetic process, sphingosine biosynthetic process; MF: acyltransferase activity, protein binding, pyridoxal phosphate binding, serine C-palmitoyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, serine palmitoyltransferase complex
Pathways: Fabry disease, Gaucher Disease, Globoid Cell Leukodystrophy, Krabbe disease, Metachromatic Leukodystrophy (MLD), Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Sphingolipid Metabolism, Sphingolipid Metabolism (general overview), Sphingolipid Metabolism (integrated pathway), Sphingolipid metabolism - Homo sapiens (human), Sphingolipid pathway, Sphingolipid signaling pathway - Homo sapiens (human), ceramide <i>de novo</i> biosynthesis
UniProt: O15269
Entrez ID: 10558
|
Does Knockout of LAGE3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
LAGE3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: LAGE3 (L antigen family member 3)
Type: protein-coding
Summary: This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: tRNA processing, tRNA threonylcarbamoyladenosine metabolic process; CC: EKC/KEOPS complex, cytoplasm, nuclear body, nucleoplasm, nucleus
Pathways: Metabolism of RNA, tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q14657
Entrez ID: 8270
|
Does Knockout of CLK2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
CLK2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: CLK2 (CDC like kinase 2)
Type: protein-coding
Summary: This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
Gene Ontology: BP: negative regulation of gluconeogenesis, protein autophosphorylation, protein phosphorylation, regulation of RNA splicing, response to ionizing radiation; MF: ATP binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: nuclear body, nuclear speck, nucleoplasm, nucleus
Pathways: mRNA Processing
UniProt: P49760
Entrez ID: 1196
|
Does Knockout of LTF in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
LTF
|
cell proliferation
|
Melanoma Cell Line
|
Gene: LTF (lactotransferrin)
Type: protein-coding
Summary: This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Activity against both DNA and RNA viruses has been found, including activity against SARS-CoV-2, and HIV. [provided by RefSeq, Jul 2021].
Gene Ontology: BP: antibacterial humoral response, antifungal humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, bone morphogenesis, cytolysis by host of symbiont cells, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, host-mediated suppression of viral proces, humoral immune response, immune system process, innate immune response, innate immune response in mucosa, iron ion transport, killing of cells of another organism, monoatomic ion transport, negative regulation of ATP-dependent activity, negative regulation of apoptotic process, negative regulation of lipopolysaccharide-mediated signaling pathway, negative regulation of membrane potential, negative regulation of osteoclast development, negative regulation of single-species biofilm formation in or on host organism, negative regulation of tumor necrosis factor (ligand) superfamily member 11 production, negative regulation of viral genome replication, negative regulation of viral process, ossification, positive regulation of NF-kappaB transcription factor activity, positive regulation of bone mineralization involved in bone maturation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of chondrocyte proliferation, positive regulation of osteoblast differentiation, positive regulation of osteoblast proliferation, positive regulation of protein serine/threonine kinase activity, positive regulation of toll-like receptor 4 signaling pathway, proteolysis, regulation of cytokine production, regulation of tumor necrosis factor production; MF: DNA binding, cysteine-type endopeptidase inhibitor activity, heparin binding, hydrolase activity, iron ion binding, lipopolysaccharide binding, membrane destabilizing activity, metal ion binding, peptidase activity, protein binding, protein serine/threonine kinase activator activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cell surface, cytoplasm, early endosome, extracellular exosome, extracellular region, extracellular space, nucleus, phagocytic vesicle lumen, plasma membrane, protein-containing complex, recycling endosome, secretory granule, specific granule, specific granule lumen, tertiary granule lumen
Pathways: Amyloid fiber formation, Antimicrobial peptides, Bacterial Infection Pathways, Disease, Immune System, Infection with Mycobacterium tuberculosis, Infectious disease, Innate Immune System, Latent infection - Other responses of Mtb to phagocytosis, Male infertility, Metabolism of proteins, Metal sequestration by antimicrobial proteins, Mtb iron assimilation by chelation, Neutrophil degranulation
UniProt: P02788
Entrez ID: 4057
|
Does Knockout of GABRG1 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
GABRG1
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: GABRG1 (gamma-aminobutyric acid type A receptor subunit gamma1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chemical synaptic transmission, chloride transmembrane transport, chloride transport, gamma-aminobutyric acid signaling pathway, inhibitory synapse assembly, monoatomic ion transmembrane transport, monoatomic ion transport, synaptic transmission, GABAergic; MF: GABA receptor binding, GABA-A receptor activity, GABA-gated chloride ion channel activity, benzodiazepine receptor activity, chloride channel activity, extracellular ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, protein binding, transmembrane signaling receptor activity; CC: GABA-A receptor complex, chloride channel complex, dendrite membrane, membrane, plasma membrane, postsynapse, postsynaptic membrane, receptor complex, synapse
Pathways: GABA receptor Signaling, GABAergic synapse - Homo sapiens (human), Morphine addiction - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Nicotine addiction - Homo sapiens (human), Prader-Willi and Angelman Syndrome, Retrograde endocannabinoid signaling - Homo sapiens (human), mBDNF and proBDNF regulation of GABA neurotransmission
UniProt: Q8N1C3
Entrez ID: 2565
|
Does Knockout of NTNG1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
NTNG1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: NTNG1 (netrin G1)
Type: protein-coding
Summary: This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: axonogenesis, cell differentiation, modulation of chemical synaptic transmission, nervous system development, regulation of neuron migration, regulation of neuron projection arborization, regulation of neuron projection development, synaptic membrane adhesion; MF: cell adhesion molecule binding, cell-cell adhesion mediator activity, protein binding; CC: Schaffer collateral - CA1 synapse, extracellular region, glutamatergic synapse, membrane, plasma membrane, presynaptic active zone membrane, side of membrane
Pathways: Axon guidance - Homo sapiens (human), Cell adhesion molecules - Homo sapiens (human), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Splicing factor NOVA regulated synaptic proteins
UniProt: Q9Y2I2
Entrez ID: 22854
|
Does Knockout of GLMN in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
GLMN
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GLMN (glomulin, FKBP associated protein)
Type: protein-coding
Summary: This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: cell surface receptor signaling pathway, circulatory system development, epigenetic regulation of gene expression, muscle cell differentiation, negative regulation of T cell proliferation, negative regulation of cell population proliferation, neural tube closure, positive regulation of cytokine production, positive regulation of interleukin-2 production, positive regulation of phosphorylation, regulation of proteasomal ubiquitin-dependent protein catabolic process, vasculogenesis; MF: hepatocyte growth factor receptor binding, protein binding, signaling receptor binding, ubiquitin protein ligase binding, ubiquitin-protein transferase inhibitor activity; CC: Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, cytoplasm
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Shigellosis - Homo sapiens (human)
UniProt: Q92990
Entrez ID: 11146
|
Does Knockout of SIRT3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
SIRT3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SIRT3 (sirtuin 3)
Type: protein-coding
Summary: SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019].
Gene Ontology: BP: aerobic respiration, cellular response to stress, negative regulation of ERK1 and ERK2 cascade, negative regulation of reactive oxygen species metabolic process, peptidyl-lysine deacetylation, positive regulation of catalase activity, positive regulation of ceramide biosynthetic process, positive regulation of insulin secretion, positive regulation of oxidative phosphorylation, positive regulation of superoxide dismutase activity, protein deacetylation; MF: NAD+ binding, NAD+ poly-ADP-ribosyltransferase activity, NAD+-protein mono-ADP-ribosyltransferase activity, NAD-dependent protein lysine deacetylase activity, NAD-dependent protein lysine delactylase activity, acyltransferase activity, transferring groups other than amino-acyl groups, enzyme binding, histone deacetylase activity, NAD-dependent, metal ion binding, protein binding, protein lysine deacetylase activity, sequence-specific DNA binding, transferase activity, zinc ion binding; CC: mitochondrial matrix, mitochondrion, nucleoplasm, nucleus, protein-containing complex
Pathways: Aerobic respiration and respiratory electron transport, Cellular responses to stimuli, Cellular responses to stress, Central carbon metabolism in cancer - Homo sapiens (human), Citric acid cycle (TCA cycle), Energy Metabolism, FOXO-mediated transcription, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Gene expression (Transcription), Generic Transcription Pathway, Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial biogenesis, Mitochondrial unfolded protein response (UPRmt), NAD Metabolism in Oncogene-Induced Senescence and Mitochondrial Dysfunction-Associated Senescence, NAD metabolism, sirtuins and aging, NAD+ biosynthetic pathways, NAD+ metabolism, Nicotinate and nicotinamide metabolism - Homo sapiens (human), Organelle biogenesis and maintenance, RNA Polymerase II Transcription, Regulation of FOXO transcriptional activity by acetylation, Signaling events mediated by HDAC Class III, Transcriptional activation of mitochondrial biogenesis
UniProt: Q9NTG7
Entrez ID: 23410
|
Does Knockout of INTS5 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
INTS5
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: INTS5 (integrator complex subunit 5)
Type: protein-coding
Summary: The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, regulation of transcription elongation by RNA polymerase II, snRNA 3'-end processing, snRNA processing; CC: INTAC complex, cytoplasm, cytosol, integrator complex, membrane, nuclear membrane, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q6P9B9
Entrez ID: 80789
|
Does Knockout of DNAL4 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,391
|
Knockout
|
DNAL4
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: DNAL4 (dynein axonemal light chain 4)
Type: protein-coding
Summary: This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: microtubule-based movement, microtubule-based process; MF: identical protein binding, microtubule motor activity, protein binding; CC: cell projection, cilium, cytoplasm, cytoskeleton, dynein complex, microtubule, plasma membrane
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Retrograde neurotrophin signalling, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases
UniProt: O96015
Entrez ID: 10126
|
Does Knockout of STMN1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
STMN1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: STMN1 (stathmin 1)
Type: protein-coding
Summary: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
Gene Ontology: BP: axonogenesis, cell differentiation, establishment of skin barrier, hepatocyte growth factor receptor signaling pathway, intracellular signal transduction, microtubule depolymerization, mitotic cytokinesis, mitotic spindle organization, negative regulation of Rho protein signal transduction, negative regulation of guanyl-nucleotide exchange factor activity, negative regulation of microtubule polymerization, negative regulation of stress fiber assembly, negative regulation of thrombin-activated receptor signaling pathway, nervous system development, neuron projection development, regulation of cell migration, regulation of microtubule polymerization or depolymerization, response to virus, signal transduction; MF: protein binding, tubulin binding; CC: cytoplasm, cytoskeleton, cytosol, extracellular exosome, membrane, microtubule, neuron projection
Pathways: Aurora B signaling, EGF-EGFR signaling pathway, IL-18 signaling pathway, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), MicroRNAs in cancer - Homo sapiens (human), Nuclear signaling by ERBB4, RAC1-PAK1-p38-MMP2 Pathway, Regulation of Microtubule Cytoskeleton, Regulatory circuits of the STAT3 signaling pathway, Retinoblastoma gene in cancer, Signal Transduction, Signaling by ERBB4, Signaling by Receptor Tyrosine Kinases, Signaling mediated by p38-gamma and p38-delta, stathmin and breast cancer resistance to antimicrotubule agents
UniProt: P16949
Entrez ID: 3925
|
Does Knockout of UNC5C in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
UNC5C
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: UNC5C (unc-5 netrin receptor C)
Type: protein-coding
Summary: This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anterior/posterior axon guidance, apoptotic process, axon guidance, brain development, chemorepulsion of axon, dorsal root ganglion development, ectopic germ cell programmed cell death, netrin-activated signaling pathway, positive regulation of apoptotic process, positive regulation of developmental process, positive regulation of reproductive process, regulation of cell migration, regulation of neuron migration, signal transduction; MF: netrin receptor activity, netrin receptor activity involved in chemorepulsion, protein binding, protein kinase binding, tubulin binding; CC: axon, cell projection, cell surface, dendrite, filopodium, growth cone, lamellipodium, membrane, neuron projection, neuronal cell body, plasma membrane, synapse
Pathways: Axon guidance, Axon guidance - Homo sapiens (human), Developmental Biology, Nervous system development, Netrin mediated repulsion signals, Netrin-1 signaling, Netrin-mediated signaling events
UniProt: O95185
Entrez ID: 8633
|
Does Knockout of RELB in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
RELB
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: RELB (RELB proto-oncogene, NF-kB subunit)
Type: protein-coding
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in cytosol and nucleoplasm. Part of chromatin; nucleus; and transcription repressor complex. Colocalizes with centrosome. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: T-helper 1 cell differentiation, T-helper 1 type immune response, antigen processing and presentation, canonical NF-kappaB signal transduction, cellular response to osmotic stress, circadian regulation of gene expression, inflammatory response, innate immune response, lymphocyte differentiation, myeloid dendritic cell differentiation, negative regulation of DNA-templated transcription, negative regulation of interferon-beta production, negative regulation of macromolecule biosynthetic process, non-canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of gene expression, response to cytokine, rhythmic process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein binding, protein kinase binding; CC: NF-kappaB complex, centrosome, chromatin, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus, protein-containing complex, synapse, transcription repressor complex
Pathways: Alternative NF-kappaB pathway, C-type lectin receptor signaling pathway - Homo sapiens (human), C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, CLEC7A (Dectin-1) signaling, Cytokine Signaling in Immune system, Dectin-1 mediated noncanonical NF-kB signaling, EDA signaling in hair follicle development, Ebola Virus Pathway on Host, Epstein-Barr virus infection - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), IL12-mediated signaling events, Immune System, Innate Immune System, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), NF-kappa B signaling pathway - Homo sapiens (human), NIK-->noncanonical NF-kB signaling, Non-genomic actions of 1,25 dihydroxyvitamin D3, Osteoclast differentiation - Homo sapiens (human), Photodynamic therapy-induced NF-kB survival signaling, RANKL-RANK signaling pathway, TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, TNFR2 non-canonical NF-kB pathway, TNFalpha, TSLP, Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, Toll-like Receptor Signaling related to MyD88, miRNAs involvement in the immune response in sepsis
UniProt: Q01201
Entrez ID: 5971
|
Does Knockout of TTC34 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
TTC34
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: TTC34 (tetratricopeptide repeat domain 34)
Type: protein-coding
Summary: tetratricopeptide repeat domain 34
Gene Ontology:
Pathways:
UniProt: A8MYJ7
Entrez ID: 100287898
|
Does Knockout of AURKB in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
AURKB
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: AURKB (aurora kinase B)
Type: protein-coding
Summary: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, cGAS/STING signaling pathway, cell cycle G2/M phase transition, cell division, cellular response to UV, cleavage furrow formation, midbody abscission, mitotic cell cycle, mitotic cytokinesis, mitotic cytokinesis checkpoint signaling, mitotic sister chromatid biorientation, mitotic spindle assembly, mitotic spindle midzone assembly, mitotic spindle organization, negative regulation of B cell apoptotic process, negative regulation of cGAS/STING signaling pathway, negative regulation of cytokinesis, negative regulation of innate immune response, negative regulation of transcription by RNA polymerase II, positive regulation of attachment of mitotic spindle microtubules to kinetochore, positive regulation of cell cycle process, positive regulation of cytokinesis, positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore, positive regulation of microtubule depolymerization, positive regulation of mitotic cell cycle spindle assembly checkpoint, positive regulation of mitotic cytokinesis, positive regulation of mitotic sister chromatid segregation, positive regulation of mitotic sister chromatid separation, positive regulation of telomere maintenance, post-translational protein modification, protein localization to kinetochore, regulation of chromosome segregation, regulation of cytokinesis, regulation of microtubule-based process, regulation of signal transduction by p53 class mediator, repair of mitotic kinetochore microtubule attachment defect, spindle organization; MF: ATP binding, kinase activity, kinase binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, transferase activity; CC: centrosome, chromocenter, chromosome, chromosome passenger complex, chromosome, centromeric region, condensed chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, microtubule cytoskeleton, midbody, mitotic spindle midzone, mitotic spindle pole, nucleoplasm, nucleus, spindle, spindle microtubule, spindle midzone, spindle pole
Pathways: APC/C-mediated degradation of cell cycle proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, ATM Signaling Network in Development and Disease, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Aurora A signaling, Aurora B signaling, Aurora C signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, FOXM1 transcription factor network, Gene expression (Transcription), Generic Transcription Pathway, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, Regulation of MECP2 expression and activity, Regulation of Microtubule Cytoskeleton, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of mitotic cell cycle, Resolution of Sister Chromatid Cohesion, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional Regulation by MECP2, Transcriptional Regulation by TP53
UniProt: Q96GD4
Entrez ID: 9212
|
Does Knockout of GPX4 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
GPX4
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: GPX4 (glutathione peroxidase 4)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. [provided by RefSeq, Dec 2018].
Gene Ontology: BP: apoptotic process, arachidonate metabolic process, cellular oxidant detoxification, cerebellum development, chromatin organization, dendrite development, lipid metabolic process, lipoxygenase pathway, long-chain fatty acid biosynthetic process, multicellular organism growth, negative regulation of ferroptosis, phospholipid metabolic process, protein polymerization, response to estradiol, response to lipopolysaccharide, response to oxidative stress, spermatogenesis; MF: glutathione peroxidase activity, identical protein binding, oxidoreductase activity, peroxidase activity, phospholipid-hydroperoxide glutathione peroxidase activity, protein binding, selenium binding; CC: cytoplasm, cytosol, extracellular exosome, mitochondrion, nuclear envelope, nucleus, protein-containing complex
Pathways: Biosynthesis of D-series resolvins, Biosynthesis of DHA-derived SPMs, Biosynthesis of E-series 18(R)-resolvins, Biosynthesis of E-series 18(S)-resolvins, Biosynthesis of EPA-derived SPMs, Biosynthesis of aspirin-triggered D-series resolvins, Biosynthesis of specialized proresolving mediators (SPMs), Ferroptosis, Ferroptosis - Homo sapiens (human), Folate Metabolism, Glutathione metabolism, Glutathione metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, Metapathway biotransformation Phase I and II, One-carbon metabolism and related pathways, Selenium Micronutrient Network, glutathione redox reactions I
UniProt: P36969
Entrez ID: 2879
|
Does Knockout of ANP32E in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
ANP32E
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ANP32E (acidic nuclear phosphoprotein 32 family member E)
Type: protein-coding
Summary: Enables histone binding activity. Involved in histone exchange. Located in nucleus. Part of Swr1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, protein folding, regulation of apoptotic process; MF: histone binding, histone chaperone activity, phosphatase inhibitor activity, protein binding, protein folding chaperone; CC: Swr1 complex, cytoplasm, cytoplasmic vesicle, glutamatergic synapse, nucleus, postsynaptic density membrane, postsynaptic endosome membrane, synaptic vesicle membrane
Pathways:
UniProt: Q9BTT0
Entrez ID: 81611
|
Does Knockout of SNCAIP in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
SNCAIP
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: SNCAIP (synuclein alpha interacting protein)
Type: protein-coding
Summary: This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cell death, dopamine metabolic process, regulation of inclusion body assembly, regulation of neurotransmitter secretion; MF: identical protein binding, protein binding, ubiquitin protein ligase binding; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, neuronal cell body, nucleoplasm, presynaptic membrane, synaptic vesicle
Pathways: Alpha-synuclein signaling, Amyloid fiber formation, Metabolism of proteins, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Parkinson,s disease pathway, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
UniProt: Q9Y6H5
Entrez ID: 9627
|
Does Knockout of TNS4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
TNS4
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: TNS4 (tensin 4)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: actin binding, protein binding; CC: anchoring junction, cytoplasm, cytoskeleton, cytosol, focal adhesion
Pathways: EGFR1, Glucocorticoid Receptor Pathway, MET interacts with TNS proteins, MET promotes cell motility, Nuclear Receptors Meta-Pathway, Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases
UniProt: Q8IZW8
Entrez ID: 84951
|
Does Knockout of XRN2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
XRN2
|
cell proliferation
|
Cancer Cell Line
|
Gene: XRN2 (5'-3' exoribonuclease 2)
Type: protein-coding
Summary: This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: DNA-templated transcription termination, RNA catabolic process, RNA metabolic process, RNA processing, hippocampus development, mRNA processing, neuron differentiation, nuclear-transcribed mRNA catabolic process, nucleobase-containing compound metabolic process, rRNA processing, retina development in camera-type eye, spermatogenesis, termination of RNA polymerase II transcription; MF: 3'-5'-RNA exonuclease activity, 5'-3' RNA exonuclease activity, 5'-3' exonuclease activity, DNA binding, RNA binding, exonuclease activity, hydrolase activity, identical protein binding, metal ion binding, nuclease activity, nucleic acid binding, protein binding, transcription termination site sequence-specific DNA binding, zinc ion binding; CC: aggresome, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nuclear RNA decay, Protein folding, RNA degradation - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), mRNA Processing, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9H0D6
Entrez ID: 22803
|
Does Knockout of STK3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
STK3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: STK3 (serine/threonine kinase 3)
Type: protein-coding
Summary: This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: JNK cascade, apoptotic process, canonical Wnt signaling pathway, cell differentiation involved in embryonic placenta development, cell population proliferation, central nervous system development, centrosome separation, endocardium development, epithelial cell proliferation, extrinsic apoptotic signaling pathway via death domain receptors, hepatocyte apoptotic process, hippo signaling, intracellular signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation, negative regulation of organ growth, neural tube formation, organ growth, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of JNK cascade, positive regulation of apoptotic process, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of fat cell differentiation, positive regulation of hippo signaling, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, primitive hemopoiesis, protein import into nucleus, protein localization to centrosome, protein phosphorylation, protein stabilization, protein tetramerization, regulation of MAPK cascade, regulation of cell differentiation involved in embryonic placenta development, regulation of gene expression, signal transduction; MF: ATP binding, identical protein binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activator activity, protein serine/threonine kinase activity, transcription regulator activator activity, transferase activity; CC: centrosome, cytoplasm, cytoskeleton, cytosol, nucleus, protein-containing complex
Pathways: Hippo signaling pathway - Homo sapiens (human), Hippo signaling pathway - multiple species - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Hippo-Yap signaling pathway, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Overview of leukocyte-intrinsic Hippo pathway functions, Pathways Regulating Hippo Signaling, Signal Transduction, Signaling by Hippo, Transcription co-factors SKI and SKIL protein partners
UniProt: Q13188
Entrez ID: 6788
|
Does Knockout of NOTO in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
NOTO
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: NOTO (notochord homeobox)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in central nervous system development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic organ development; motile cilium assembly; and regulation of cilium assembly. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: brain development, central nervous system development, determination of left/right symmetry, dorsal/ventral pattern formation, embryonic pattern specification, heart looping, motile cilium assembly, neuron differentiation, notochord development, regulation of cilium assembly, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways: Developmental Biology, Formation of axial mesoderm, Gastrulation
UniProt: A8MTQ0
Entrez ID: 344022
|
Does Knockout of RSRC1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
RSRC1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RSRC1 (arginine and serine rich coiled-coil 1)
Type: protein-coding
Summary: This gene encodes a member of the serine and arginine rich-related protein family. The encoded protein is involved in both constitutive and alternative mRNA splicing. This gene may be associated with schizophrenia. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, nucleocytoplasmic transport, response to antibiotic; CC: cytoplasm, nuclear speck, nucleus
Pathways:
UniProt: Q96IZ7
Entrez ID: 51319
|
Does Knockout of RNF130 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
RNF130
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: RNF130 (ring finger protein 130)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: apoptotic process, programmed cell death, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, membrane
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q86XS8
Entrez ID: 55819
|
Does Knockout of MAN1C1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
MAN1C1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MAN1C1 (mannosidase alpha class 1C member 1)
Type: protein-coding
Summary: Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERAD pathway, Golgi apparatus mannose trimming, N-glycan processing, carbohydrate metabolic process, protein N-linked glycosylation, protein glycosylation; MF: calcium ion binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, mannosyl-oligosaccharide 1,2-alpha-mannosidase activity, metal ion binding, protein binding; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, extracellular exosome, membrane
Pathways: Asparagine N-linked glycosylation, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), N-glycan trimming and elongation in the cis-Golgi, Post-translational protein modification, Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2, Protein processing in endoplasmic reticulum - Homo sapiens (human), Transport to the Golgi and subsequent modification, Various types of N-glycan biosynthesis - Homo sapiens (human), Vesicle-mediated transport, er associated degradation (erad) pathway
UniProt: Q9NR34
Entrez ID: 57134
|
Does Knockout of EIF3M in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
EIF3M
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: EIF3M (eukaryotic translation initiation factor 3 subunit M)
Type: protein-coding
Summary: This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation; MF: protein binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, protein-containing complex
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, Ribosomal scanning and start codon recognition, TCR, Translation, Translation initiation complex formation
UniProt: Q7L2H7
Entrez ID: 10480
|
Does Knockout of NCMAP in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
NCMAP
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: NCMAP (non-compact myelin associated protein)
Type: protein-coding
Summary: Predicted to be a structural constituent of myelin sheath. Predicted to be involved in peripheral nervous system myelin formation and positive regulation of myelination. Predicted to be integral component of plasma membrane. Predicted to be active in Schmidt-Lanterman incisure and paranode region of axon. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: peripheral nervous system myelin formation, positive regulation of myelination, regulation of myelination; MF: structural constituent of myelin sheath; CC: Schmidt-Lanterman incisure, membrane, paranode region of axon, plasma membrane
Pathways:
UniProt: Q5T1S8
Entrez ID: 400746
|
Does Knockout of PRMT5 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
PRMT5
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PRMT5 (protein arginine methyltransferase 5)
Type: protein-coding
Summary: This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: DNA-templated transcription termination, Golgi ribbon formation, chromatin organization, chromatin remodeling, circadian regulation of gene expression, endothelial cell activation, liver regeneration, methylation, negative regulation of DNA-templated transcription, negative regulation of cell differentiation, negative regulation of gene expression via chromosomal CpG island methylation, peptidyl-arginine N-methylation, peptidyl-arginine methylation, positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway, positive regulation of mRNA splicing, via spliceosome, positive regulation of oligodendrocyte differentiation, regulation of DNA-templated transcription, regulation of ERK1 and ERK2 cascade, regulation of gene expression, regulation of mitotic nuclear division, regulation of signal transduction by p53 class mediator, rhythmic process, spliceosomal snRNP assembly; MF: E-box binding, histone H3 methyltransferase activity, histone H4R3 methyltransferase activity, histone arginine N-methyltransferase activity, histone methyltransferase activity, identical protein binding, methyl-CpG binding, methyltransferase activity, p53 binding, protein binding, protein heterodimerization activity, protein-arginine N-methyltransferase activity, protein-arginine omega-N symmetric methyltransferase activity, protein-containing complex binding, ribonucleoprotein complex binding, transcription corepressor activity, transferase activity; CC: Golgi apparatus, chromatin, chromosome, cytoplasm, cytosol, histone methyltransferase complex, methylosome, nucleoplasm, nucleus, protein-containing complex
Pathways: Chromatin modifying enzymes, Chromatin organization, E2F transcription factor network, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, Metabolism of non-coding RNA, NO metabolism in cystic fibrosis, RMTs methylate histone arginines, RNA Polymerase II Transcription, RNA transport - Homo sapiens (human), Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Signaling events mediated by HDAC Class I, Transcription co-factors SKI and SKIL protein partners, Transcriptional Regulation by TP53, p53 pathway, snRNP Assembly
UniProt: O14744
Entrez ID: 10419
|
Does Knockout of TMSB4Y in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
TMSB4Y
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: TMSB4Y (thymosin beta 4 Y-linked)
Type: protein-coding
Summary: This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin filament organization, regulation of actin polymerization or depolymerization, regulation of cell migration; MF: actin binding, actin monomer binding, protein binding, protein sequestering activity; CC: cytoplasm, cytoskeleton, cytosol, nucleus
Pathways: Regulation of actin cytoskeleton - Homo sapiens (human)
UniProt: O14604
Entrez ID: 9087
|
Does Knockout of NAGK in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
NAGK
|
cell proliferation
|
T-lymphoma cell line
|
Gene: NAGK (N-acetylglucosamine kinase)
Type: protein-coding
Summary: This gene encodes a member of the N-acetylhexosamine kinase family. The encoded protein catalyzes the conversion of N-acetyl-D-glucosamine to N-acetyl-D-glucosamine 6-phosphate, and is the major mammalian enzyme which recovers amino sugars. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: N-acetylglucosamine catabolic process, N-acetylglucosamine metabolic process, N-acetylmannosamine metabolic process, N-acetylneuraminate catabolic process, UDP-N-acetylglucosamine biosynthetic process, canonical NF-kappaB signal transduction, carbohydrate phosphorylation, defense response to bacterium, immune system process, innate immune response, negative regulation of canonical NF-kappaB signal transduction, nucleotide-binding oligomerization domain containing 2 signaling pathway, p38MAPK cascade, positive regulation of canonical NF-kappaB signal transduction, positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway, protein K63-linked ubiquitination, protein linear polyubiquitination, response to muramyl dipeptide; MF: ATP binding, N-acetylglucosamine kinase activity, N-acylmannosamine kinase activity, kinase activity, muramyl dipeptide kinase activity, nucleotide binding, protein binding, transferase activity; CC: cytosol, extracellular exosome
Pathways: 2-Hydroxyglutric Aciduria (D And L Form), 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency, <i>N</i>-acetylglucosamine degradation II, Amino Sugar Metabolism, Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), G(M2)-Gangliosidosis: Variant B, Tay-sachs disease, Glutamate Metabolism, Homocarnosinosis, Hyperinsulinism-Hyperammonemia Syndrome, Salla Disease/Infantile Sialic Acid Storage Disease, Sialuria or French Type Sialuria, Succinic semialdehyde dehydrogenase deficiency, Tay-Sachs Disease
UniProt: Q9UJ70
Entrez ID: 55577
|
Does Knockout of LRRC14 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
LRRC14
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: LRRC14 (leucine rich repeat containing 14)
Type: protein-coding
Summary: This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: negative regulation of NF-kappaB transcription factor activity, negative regulation of toll-like receptor signaling pathway; MF: kinase binding, protein binding; CC: cytoplasm, cytosol
Pathways: Cytokine Signaling in Immune system, Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Regulation of NF-kappa B signaling, Signaling by Interleukins, TAK1-dependent IKK and NF-kappa-B activation , TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: Q15048
Entrez ID: 9684
|
Does Knockout of MMS19 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
MMS19
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: MMS19 (MMS19 cytosolic iron-sulfur assembly component)
Type: protein-coding
Summary: Enables estrogen receptor binding activity and transcription coactivator activity. Involved in several processes, including iron-sulfur cluster assembly; positive regulation of nucleobase-containing compound metabolic process; and protein maturation by iron-sulfur cluster transfer. Located in cytosol; nucleoplasm; and spindle. Part of CIA complex and MMXD complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, chromosome segregation, positive regulation of DNA-templated transcription, protein maturation; MF: enzyme binding, nuclear estrogen receptor binding, protein binding, protein-macromolecule adaptor activity, signaling receptor complex adaptor activity, transcription coactivator activity; CC: MMXD complex, centrosome, cytoplasm, cytoskeleton, cytosol, cytosolic [4Fe-4S] assembly targeting complex, membrane, nucleoplasm, nucleus, spindle, transcription factor TFIIH holo complex
Pathways: Cytosolic iron-sulfur cluster assembly, Metabolism
UniProt: Q96T76
Entrez ID: 64210
|
Does Knockout of ZSCAN12 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
ZSCAN12
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: ZSCAN12 (zinc finger and SCAN domain containing 12)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: O43309
Entrez ID: 9753
|
Does Knockout of HAUS5 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
HAUS5
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: HAUS5 (HAUS augmin like complex subunit 5)
Type: protein-coding
Summary: HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010].
Gene Ontology: BP: cell division, centrosome cycle, regulation of microtubule nucleation, spindle assembly; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule, mitotic spindle microtubule, spindle
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: O94927
Entrez ID: 23354
|
Does Knockout of TMSB10 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
TMSB10
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TMSB10 (thymosin beta 10)
Type: protein-coding
Summary: Predicted to enable actin monomer binding activity. Predicted to be involved in regulation of cell migration and sequestering of actin monomers. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin filament organization, regulation of cell migration; MF: actin binding, actin monomer binding, protein binding, protein sequestering activity; CC: cytoplasm, cytoskeleton
Pathways: VEGFA-VEGFR2 Signaling Pathway
UniProt: P63313
Entrez ID: 9168
|
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