prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of NSG1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | NSG1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: NSG1 (neuronal vesicle trafficking associated 1)
Type: protein-coding
Summary: Predicted to enable clathrin light chain binding activity. Involved in apoptotic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: amyloid precur... |
Does Knockout of KLHL11 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | KLHL11 | cell proliferation | Colonic Cancer Cell Line | Gene: KLHL11 (kelch like family member 11)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, cytopla... |
Does Knockout of TNFSF11 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | TNFSF11 | cell proliferation | T-lymphoma cell line | Gene: TNFSF11 (TNF superfamily member 11)
Type: protein-coding
Summary: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentriti... |
Does Knockout of PSMB4 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | PSMB4 | cell proliferation | Colonic Cancer Cell Line | Gene: PSMB4 (proteasome 20S subunit beta 4)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rin... |
Does Knockout of OR6P1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | OR6P1 | cell proliferation | Medulloblastoma Cell Line | Gene: OR6P1 (olfactory receptor family 6 subfamily P member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of MIR302B in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | MIR302B | response to chemicals | Glioblastoma Cell Line | Gene: MIR302B (microRNA 302b)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of MIR100 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | MIR100 | response to chemicals | Monocytic Leukemia Cell Line | Gene: MIR100 (microRNA 100)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I... |
Does Knockout of PKMYT1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 1 | 1,339 | Knockout | PKMYT1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphory... |
Does Knockout of METTL3 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | METTL3 | cell proliferation | Medulloblastoma Cell Line | Gene: METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)
Type: protein-coding
Summary: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine re... |
Does Knockout of MRTO4 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | MRTO4 | cell proliferation | Endometrial Cancer Cell Line | Gene: MRTO4 (MRT4 homolog, ribosome maturation factor)
Type: protein-coding
Summary: This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ri... |
Does Activation of RELT in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | RELT | protein/peptide accumulation | T cell | Gene: RELT (RELT TNF receptor)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor ... |
Does Knockout of ZNF648 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | ZNF648 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: ZNF648 (zinc finger protein 648)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-... |
Does Knockout of DEPDC1B in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | DEPDC1B | response to virus | Lung Cancer Cell Line | Gene: DEPDC1B (DEP domain containing 1B)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Involved in cell migration and positive regulation of Wnt signaling pathway. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell migration, intracellula... |
Does Knockout of IGDCC4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | IGDCC4 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: IGDCC4 (immunoglobulin superfamily DCC subclass member 4)
Type: protein-coding
Summary: Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell-cell adhesion, negative regulati... |
Does Activation of TES in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | TES | response to virus | Hepatoma Cell Line | Gene: TES (testin LIM domain protein)
Type: protein-coding
Summary: Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a common fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene en... |
Does Knockout of NCAPH in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | NCAPH | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: NCAPH (non-SMC condensin I complex subunit H)
Type: protein-coding
Summary: This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by t... |
Does Knockout of MRPS9 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | MRPS9 | cell proliferation | Melanoma Cell Line | Gene: MRPS9 (mitochondrial ribosomal protein S9)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. T... |
Does Knockout of WIPF1 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | WIPF1 | response to chemicals | Glioblastoma Cell Line | Gene: WIPF1 (WAS/WASL interacting protein family member 1)
Type: protein-coding
Summary: This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott... |
Does Knockout of TTC27 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | TTC27 | cell proliferation | Renal Cancer Cell Line | Gene: TTC27 (tetratricopeptide repeat domain 27)
Type: protein-coding
Summary: tetratricopeptide repeat domain 27
Gene Ontology:
Pathways:
UniProt: Q6P3X3
Entrez ID: 55622 |
Does Knockout of SPINK8 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | SPINK8 | response to virus | Huh-7 Cell | Gene: SPINK8 (serine peptidase inhibitor Kazal type 8 (putative))
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular region. [provided by Allia... |
Does Knockout of CYTH4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | CYTH4 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: CYTH4 (cytohesin 4)
Type: protein-coding
Summary: This gene encodes a member of the PSCD family of proteins, which have an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain c... |
Does Knockout of AMH in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | AMH | cell proliferation | Monocytic Leukemia Cell Line | Gene: AMH (anti-Mullerian hormone)
Type: protein-coding
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factor... |
Does Knockout of RACK1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | RACK1 | cell proliferation | Medulloblastoma Cell Line | Gene: RACK1 (receptor for activated C kinase 1)
Type: protein-coding
Summary: Enables several functions, including cyclin binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulatio... |
Does Knockout of TSPAN6 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | TSPAN6 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: TSPAN6 (tetraspanin 6)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The protei... |
Does Knockout of DDX54 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | DDX54 | cell proliferation | Endometrial Cancer Cell Line | Gene: DDX54 (DEAD-box helicase 54)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alterati... |
Does Activation of MAP3K1 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | MAP3K1 | response to virus | Hepatoma Cell Line | Gene: MAP3K1 (mitogen-activated protein kinase kinase kinase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein i... |
Does Knockout of MYBL1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | MYBL1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: MYBL1 (MYB proto-oncogene like 1)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II... |
Does Knockout of NOC2L in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | NOC2L | cell proliferation | Cancer Cell Line | Gene: NOC2L (NOC2 like nucleolar associated transcriptional repressor)
Type: protein-coding
Summary: Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of hi... |
Does Knockout of PIH1D2 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | PIH1D2 | cell proliferation | Neuroblastoma Cell Line | Gene: PIH1D2 (PIH1 domain containing 2)
Type: protein-coding
Summary: Enables small GTPase binding activity. Predicted to be involved in box C/D snoRNP assembly and rRNA processing. Predicted to be part of R2TP complex and ribonucleoprotein complex. Predicted to be active in cytoplasm. [provided by Alli... |
Does Knockout of DBF4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | DBF4 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: DBF4 (DBF4-CDC7 kinase regulatory subunit)
Type: protein-coding
Summary: Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Located in nuclear b... |
Does Knockout of TCEAL7 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | TCEAL7 | cell proliferation | Cancer Cell Line | Gene: TCEAL7 (transcription elongation factor A like 7)
Type: protein-coding
Summary: Predicted to enable WW domain binding activity. Involved in negative regulation of NF-kappaB transcription factor activity and negative regulation of transcription, DNA-templated. Located in nucleoplasm. [provided by A... |
Does Knockout of SARS2 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | SARS2 | cell proliferation | Renal Cancer Cell Line | Gene: SARS2 (seryl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis o... |
Does Knockout of STK32B in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | STK32B | cell proliferation | Gastric Cancer Cell Line | Gene: STK32B (serine/threonine kinase 32B)
Type: protein-coding
Summary: This gene encodes a serine-threonine protein kinase. Serine-threonine kinases transfer phosphate molecules to the oxygen atoms of serine and threonine. A genomic deletion affecting this gene has been associated with Ellis-van Creve... |
Does Knockout of EVPL in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | EVPL | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: EVPL (envoplakin)
Type: protein-coding
Summary: This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated wi... |
Does Knockout of CDK2 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | CDK2 | cell proliferation | Cancer Cell Line | Gene: CDK2 (cyclin dependent kinase 2)
Type: protein-coding
Summary: This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progress... |
Does Knockout of GALNT4 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | GALNT4 | cell proliferation | Gastric Cancer Cell Line | Gene: GALNT4 (polypeptide N-acetylgalactosaminyltransferase 4)
Type: protein-coding
Summary: This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi ... |
Does Knockout of ATF6 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | ATF6 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ATF6 (activating transcription factor 6)
Type: protein-coding
Summary: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is... |
Does Knockout of SNAPC1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | SNAPC1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SNAPC1 (small nuclear RNA activating complex polypeptide 1)
Type: protein-coding
Summary: Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in snRNA transcription by RNA polymerase II and snRNA transcription by RNA polymerase III. Located in nucleolus and nucleop... |
Does Activation of TRIM28 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | TRIM28 | protein/peptide accumulation | T cell | Gene: TRIM28 (tripartite motif containing 28)
Type: protein-coding
Summary: The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to assoc... |
Does Knockout of DGCR2 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | DGCR2 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: DGCR2 (DiGeorge syndrome critical region gene 2)
Type: protein-coding
Summary: Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects)... |
Does Knockout of MRFAP1L1 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | MRFAP1L1 | cell proliferation | Cancer Cell Line | Gene: MRFAP1L1 (Morf4 family associated protein 1 like 1)
Type: protein-coding
Summary: Enables identical protein binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: identical protein binding, protein binding
Pathways:
UniProt: Q96HT8
... |
Does Knockout of GTF2H4 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | GTF2H4 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: GTF2H4 (general transcription factor IIH subunit 4)
Type: protein-coding
Summary: Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and trans... |
Does Knockout of NOL7 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | NOL7 | cell proliferation | Bladder Carcinoma | Gene: NOL7 (nucleolar protein 7)
Type: protein-coding
Summary: The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene r... |
Does Knockout of LYST in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | LYST | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: LYST (lysosomal trafficking regulator)
Type: protein-coding
Summary: This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Al... |
Does Knockout of XRCC6 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | XRCC6 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: XRCC6 (X-ray repair cross complementing 6)
Type: protein-coding
Summary: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be... |
Does Knockout of SNRNP25 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | SNRNP25 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SNRNP25 (small nuclear ribonucleoprotein U11/U12 subunit 25)
Type: protein-coding
Summary: Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U1... |
Does Knockout of RALBP1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | RALBP1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: RALBP1 (ralA binding protein 1)
Type: protein-coding
Summary: RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shif... |
Does Knockout of GC in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | GC | response to chemicals | Colorectal Cancer Cell Line | Gene: GC (GC vitamin D binding protein)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metab... |
Does Knockout of RPL32 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | RPL32 | cell proliferation | Glioblastoma Cell Line | Gene: RPL32 (ribosomal protein L32)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of RREB1 in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | RREB1 | response to virus | Hepatoma Cell Line | Gene: RREB1 (ras responsive element binding protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the enc... |
Does Knockout of GCSH in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | GCSH | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: GCSH (glycine cleavage system protein H)
Type: protein-coding
Summary: Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-con... |
Does Knockout of PPP1R11 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | PPP1R11 | cell proliferation | Medulloblastoma Cell Line | Gene: PPP1R11 (protein phosphatase 1 regulatory inhibitor subunit 11)
Type: protein-coding
Summary: This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major hi... |
Does Knockout of POLR2G in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | POLR2G | cell proliferation | Medulloblastoma Cell Line | Gene: POLR2G (RNA polymerase II subunit G)
Type: protein-coding
Summary: This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize t... |
Does Knockout of KCNQ4 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | KCNQ4 | cell proliferation | Monocytic Leukemia Cell Line | Gene: KCNQ4 (potassium voltage-gated channel subfamily Q member 4)
Type: protein-coding
Summary: The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current genera... |
Does Knockout of TWNK in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | TWNK | cell proliferation | Monocytic Leukemia Cell Line | Gene: TWNK (twinkle mtDNA helicase)
Type: protein-coding
Summary: This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a k... |
Does Knockout of B3GALNT2 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | B3GALNT2 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: B3GALNT2 (beta-1,3-N-acetylgalactosaminyltransferase 2)
Type: protein-coding
Summary: This gene encodes a member of the glycosyltransferase 31 family. The encoded protein synthesizes GalNAc:beta-1,3GlcNAc, a novel carbohydrate structure, on N- and O-glycans. Alternatively spliced transcript varian... |
Does Knockout of MCHR1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | MCHR1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: MCHR1 (melanin concentrating hormone receptor 1)
Type: protein-coding
Summary: The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation ... |
Does Knockout of GNG4 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | GNG4 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: GNG4 (G protein subunit gamma 4)
Type: protein-coding
Summary: Predicted to enable G-protein beta-subunit binding activity. Involved in negative regulation of cell growth. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-c... |
Does Knockout of SLK in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | SLK | response to virus | Hepatoma Cell Line | Gene: SLK (STE20 like kinase)
Type: protein-coding
Summary: Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including cytoplasmic microtubule organization; protein autophosphorylation; and regulation of focal adhesion assembly. Locat... |
Does Knockout of CSNK1A1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | CSNK1A1 | cell proliferation | Glioblastoma Cell Line | Gene: CSNK1A1 (casein kinase 1 alpha 1)
Type: protein-coding
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-depen... |
Does Knockout of MRPS5 in Colonic Adenocarcinoma Cell Line causally result in response to virus? | 1 | 1,387 | Knockout | MRPS5 | response to virus | Colonic Adenocarcinoma Cell Line | Gene: MRPS5 (mitochondrial ribosomal protein S5)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. T... |
Does Knockout of GYPB in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | GYPB | cell proliferation | Colonic Cancer Cell Line | Gene: GYPB (glycophorin B (MNS blood group))
Type: protein-coding
Summary: Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology w... |
Does Knockout of PSMD12 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | PSMD12 | cell proliferation | Cancer Cell Line | Gene: PSMD12 (proteasome 26S subunit, non-ATPase 12)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings ... |
Does Knockout of ANKLE2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | ANKLE2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ANKLE2 (ankyrin repeat and LEM domain containing 2)
Type: protein-coding
Summary: This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene caus... |
Does Knockout of DHX36 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | DHX36 | cell proliferation | Astrocytoma Cell Line | Gene: DHX36 (DEAH-box helicase 36)
Type: protein-coding
Summary: This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and dec... |
Does Knockout of MED24 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | MED24 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: MED24 (mediator complex subunit 24)
Type: protein-coding
Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited b... |
Does Knockout of NCR1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | NCR1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: NCR1 (natural cytotoxicity triggering receptor 1)
Type: protein-coding
Summary: Predicted to be involved in cellular defense response; regulation of natural killer cell mediated cytotoxicity; and signal transduction. Predicted to act upstream of or within defense response to virus and detection of... |
Does Knockout of PRMT1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | PRMT1 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: PRMT1 (protein arginine methyltransferase 1)
Type: protein-coding
Summary: This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMT... |
Does Knockout of TAF1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | TAF1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: TAF1 (TATA-box binding protein associated factor 1)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core pr... |
Does Knockout of CSTF1 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | CSTF1 | response to chemicals | Glioblastoma Cell Line | Gene: CSTF1 (cleavage stimulation factor subunit 1)
Type: protein-coding
Summary: This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this ... |
Does Knockout of CLNS1A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | CLNS1A | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: CLNS1A (chloride nucleotide-sensitive channel 1A)
Type: protein-coding
Summary: This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleo... |
Does Knockout of SH2D3A in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | SH2D3A | response to chemicals | Colorectal Cancer Cell Line | Gene: SH2D3A (SH2 domain containing 3A)
Type: protein-coding
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and phosphotyrosine residue binding activity. Predicted to be involved in positive regulation of peptidyl-serine phosphorylation. [provided by Alliance of Genome Resources... |
Does Knockout of STEAP1 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | STEAP1 | cell proliferation | Gastric Cancer Cell Line | Gene: STEAP1 (STEAP family member 1)
Type: protein-coding
Summary: This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significan... |
Does Knockout of SIX1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | SIX1 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: SIX1 (SIX homeobox 1)
Type: protein-coding
Summary: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in t... |
Does Knockout of IFITM3 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | IFITM3 | cell proliferation | Prostate Cancer Cell Line | Gene: IFITM3 (interferon induced transmembrane protein 3)
Type: protein-coding
Summary: Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The ... |
Does Knockout of ZKSCAN2 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | ZKSCAN2 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: ZKSCAN2 (zinc finger with KRAB and SCAN domains 2)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of t... |
Does Knockout of EIF1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | EIF1 | cell proliferation | Bladder Carcinoma | Gene: EIF1 (eukaryotic translation initiation factor 1)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in regulation of translational initiation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of gene ex... |
Does Knockout of TRNAU1AP in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | TRNAU1AP | response to virus | Hepatoma Cell Line | Gene: TRNAU1AP (tRNA selenocysteine 1 associated protein 1)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of NACC2 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | NACC2 | response to virus | Lung Cancer Cell Line | Gene: NACC2 (NACC family member 2)
Type: protein-coding
Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including negative r... |
Does Knockout of ANAPC4 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | ANAPC4 | cell proliferation | Renal Cancer Cell Line | Gene: ANAPC4 (anaphase promoting complex subunit 4)
Type: protein-coding
Summary: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which... |
Does Knockout of RANBP2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | RANBP2 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: RANBP2 (RAN binding protein 2)
Type: protein-coding
Summary: RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large... |
Does Knockout of LAMTOR4 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | LAMTOR4 | cell proliferation | Medulloblastoma Cell Line | Gene: LAMTOR4 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 4)
Type: protein-coding
Summary: Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cellular response to amino acid stimulus; positive regulation of TO... |
Does Knockout of SEL1L in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | SEL1L | cell proliferation | Neuroblastoma Cell Line | Gene: SEL1L (SEL1L adaptor subunit of SYVN1 ubiquitin ligase)
Type: protein-coding
Summary: The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded ... |
Does Knockout of RAB3IP in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | RAB3IP | cell proliferation | Neuroblastoma Cell Line | Gene: RAB3IP (RAB3A interacting protein)
Type: protein-coding
Summary: Enables guanyl-nucleotide exchange factor activity and identical protein binding activity. Involved in cilium assembly; protein localization to organelle; and protein targeting to membrane. Located in centrosome; cytosol; and nucleus... |
Does Knockout of ZBTB17 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | ZBTB17 | cell proliferation | Colorectal Cancer Cell Line | Gene: ZBTB17 (zinc finger and BTB domain containing 17)
Type: protein-coding
Summary: This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008].
... |
Does Knockout of TLR7 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | TLR7 | cell proliferation | Colonic Cancer Cell Line | Gene: TLR7 (toll like receptor 7)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share stru... |
Does Knockout of SLC16A1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | SLC16A1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: SLC16A1 (solute carrier family 16 member 1)
Type: protein-coding
Summary: The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are assoc... |
Does Knockout of LRRC74A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | LRRC74A | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: LRRC74A (leucine rich repeat containing 74A)
Type: protein-coding
Summary: leucine rich repeat containing 74A
Gene Ontology:
Pathways:
UniProt: Q0VAA2
Entrez ID: 145497 |
Does Knockout of METTL3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | METTL3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit)
Type: protein-coding
Summary: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine re... |
Does Knockout of KIF4B in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | KIF4B | response to virus | Cervical Adenocarcinoma Cell Line | Gene: KIF4B (kinesin family member 4B)
Type: protein-coding
Summary: This gene is an intronless retrocopy of kinesin family member 4A. The protein encoded by this gene is a microtubule-based motor protein that plays vital roles in anaphase spindle dynamics and cytokinesis. [provided by RefSeq, Jul 2016]... |
Does Knockout of TKFC in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | TKFC | cell proliferation | Endometrial Cancer Cell Line | Gene: TKFC (triokinase and FMN cyclase)
Type: protein-coding
Summary: This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5... |
Does Knockout of AGFG2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | AGFG2 | cell proliferation | Colonic Cancer Cell Line | Gene: AGFG2 (ArfGAP with FG repeats 2)
Type: protein-coding
Summary: This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (... |
Does Knockout of GATA4 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | GATA4 | response to chemicals | Melanoma Cell Line | Gene: GATA4 (GATA binding protein 4)
Type: protein-coding
Summary: This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in em... |
Does Knockout of GEN1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | GEN1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: GEN1 (GEN1 Holliday junction 5' flap endonuclease)
Type: protein-coding
Summary: This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin... |
Does Knockout of DHPS in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | DHPS | cell proliferation | Medulloblastoma Cell Line | Gene: DHPS (deoxyhypusine synthase)
Type: protein-coding
Summary: This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes t... |
Does Knockout of GIMAP6 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | GIMAP6 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: GIMAP6 (GTPase, IMAP family member 6)
Type: protein-coding
Summary: This gene encodes a member of the GTPases of immunity-associated proteins (GIMAP) family. GIMAP proteins contain GTP-binding and coiled-coil motifs, and may play roles in the regulation of cell survival. Decreased expression of th... |
Does Knockout of TIMM29 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | TIMM29 | cell proliferation | Breast Cancer Cell Line | Gene: TIMM29 (translocase of inner mitochondrial membrane 29)
Type: protein-coding
Summary: Enables protein transporter activity. Involved in protein insertion into mitochondrial inner membrane. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of TIM22 mitochondrial im... |
Does Knockout of UGT2B4 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | UGT2B4 | cell proliferation | Melanoma Cell Line | Gene: UGT2B4 (UDP glucuronosyltransferase family 2 member B4)
Type: protein-coding
Summary: Enables glucuronosyltransferase activity. Involved in cellular glucuronidation and estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of memb... |
Does Knockout of DDX19B in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | DDX19B | cell proliferation | Mammary Gland Tumor Cell Line | Gene: DDX19B (DEAD-box helicase 19B)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiat... |
Does Activation of SLC13A5 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | SLC13A5 | response to virus | Hepatoma Cell Line | Gene: SLC13A5 (solute carrier family 13 member 5)
Type: protein-coding
Summary: This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause earl... |
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