prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of GEMIN4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | GEMIN4 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: GEMIN4 (gem nuclear organelle associated protein 4)
Type: protein-coding
Summary: The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytopl... |
Does Knockout of WNT9B in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | WNT9B | cell proliferation | Cancer Cell Line | Gene: WNT9B (Wnt family member 9B)
Type: protein-coding
Summary: The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning... |
Does Knockout of ZNF622 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | ZNF622 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ZNF622 (zinc finger protein 622)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Located in Go... |
Does Knockout of ESRRA in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | ESRRA | cell proliferation | Medulloblastoma Cell Line | Gene: ESRRA (estrogen related receptor alpha)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcript... |
Does Knockout of CWC27 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | CWC27 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: CWC27 (CWC27 spliceosome associated cyclophilin)
Type: protein-coding
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Located in nucleoplasm. Part of U2-type precatalytic spliceosome and catalytic step 2 ... |
Does Knockout of MUC15 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | MUC15 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: MUC15 (mucin 15, cell surface associated)
Type: protein-coding
Summary: Predicted to be located in Golgi lumen and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Golgi lumen, extracellular region, membrane, plasma membrane
Pathways: C-typ... |
Does Knockout of GNB4 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | GNB4 | cell proliferation | Endometrial Cancer Cell Line | Gene: GNB4 (G protein subunit beta 4)
Type: protein-coding
Summary: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related g... |
Does Knockout of SNRPB2 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | SNRPB2 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: SNRPB2 (small nuclear ribonucleoprotein polypeptide B2)
Type: protein-coding
Summary: The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies... |
Does Knockout of HBEGF in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | HBEGF | cell proliferation | Renal Cancer Cell Line | Gene: HBEGF (heparin binding EGF like growth factor)
Type: protein-coding
Summary: Enables growth factor activity and heparin binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; and positive reg... |
Does Knockout of EPCAM in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | EPCAM | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: EPCAM (epithelial cell adhesion molecule)
Type: protein-coding
Summary: This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and fu... |
Does Knockout of MIR4313 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | MIR4313 | response to virus | Hepatoma Cell Line | Gene: MIR4313 (microRNA 4313)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of ACTR2 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | ACTR2 | cell proliferation | Prostate Cancer Cell Line | Gene: ACTR2 (actin related protein 2)
Type: protein-coding
Summary: The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and mot... |
Does Knockout of MDC1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 1 | 1,340 | Knockout | MDC1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: MDC1 (mediator of DNA damage checkpoint 1)
Type: protein-coding
Summary: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required ... |
Does Knockout of PRIM1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | PRIM1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: PRIM1 (DNA primase subunit 1)
Type: protein-coding
Summary: The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a... |
Does Knockout of GTF2A1 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | GTF2A1 | cell proliferation | Renal Cancer Cell Line | Gene: GTF2A1 (general transcription factor IIA subunit 1)
Type: protein-coding
Summary: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 199... |
Does Knockout of HTRA2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | HTRA2 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: HTRA2 (HtrA serine peptidase 2)
Type: protein-coding
Summary: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitocho... |
Does Knockout of RANBP2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | RANBP2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: RANBP2 (RAN binding protein 2)
Type: protein-coding
Summary: RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large... |
Does Knockout of ABCA7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | ABCA7 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: ABCA7 (ATP binding cassette subfamily A member 7)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided int... |
Does Knockout of MEGF9 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | MEGF9 | cell proliferation | Neuroblastoma Cell Line | Gene: MEGF9 (multiple EGF like domains 9)
Type: protein-coding
Summary: Predicted to be involved in several processes, including animal organ morphogenesis; cell migration; and substrate adhesion-dependent cell spreading. Predicted to be integral component of membrane. Predicted to be active in basement... |
Does Knockout of COPG1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | COPG1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: COPG1 (coat protein complex I subunit gamma 1)
Type: protein-coding
Summary: Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Located i... |
Does Knockout of RNASE1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | RNASE1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: RNASE1 (ribonuclease A family member 1, pancreatic)
Type: protein-coding
Summary: This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidin... |
Does Knockout of GALNT6 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | GALNT6 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6)
Type: protein-coding
Summary: This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi ... |
Does Knockout of DMAP1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | DMAP1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: DMAP1 (DNA methyltransferase 1 associated protein 1)
Type: protein-coding
Summary: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci t... |
Does Knockout of NAPG in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | NAPG | cell proliferation | Glioblastoma Cell Line | Gene: NAPG (NSF attachment protein gamma)
Type: protein-coding
Summary: This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components o... |
Does Knockout of CAP1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | CAP1 | cell proliferation | Colonic Cancer Cell Line | Gene: CAP1 (cyclase associated actin cytoskeleton regulatory protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein,... |
Does Knockout of FAM162A in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | FAM162A | cell proliferation | Monocytic Leukemia Cell Line | Gene: FAM162A (family with sequence similarity 162 member A)
Type: protein-coding
Summary: Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to hypoxia; and positive regulation of release of cytochrome c from mito... |
Does Knockout of CFAP126 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | CFAP126 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: CFAP126 (cilia and flagella associated protein 126)
Type: protein-coding
Summary: Predicted to be involved in cilium organization. Predicted to be located in apical plasma membrane and cilium. Predicted to be active in ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of PAQR4 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | PAQR4 | response to virus | Lung Cancer Cell Line | Gene: PAQR4 (progestin and adipoQ receptor family member 4)
Type: protein-coding
Summary: Predicted to enable signaling receptor activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein stabilization, regulation of... |
Does Knockout of DKK1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | DKK1 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: DKK1 (dickkopf Wnt signaling pathway inhibitor 1)
Type: protein-coding
Summary: This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein bind... |
Does Knockout of NMNAT1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | NMNAT1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: NMNAT1 (nicotinamide nucleotide adenylyltransferase 1)
Type: protein-coding
Summary: This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is spec... |
Does Knockout of RASL10B in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | RASL10B | cell proliferation | Neuroblastoma Cell Line | Gene: RASL10B (RAS like family 10 member B)
Type: protein-coding
Summary: Predicted to enable G protein activity and GTP binding activity. Predicted to be involved in positive regulation of peptide hormone secretion and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Predic... |
Does Knockout of KIF20A in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 1 | 1,996 | Knockout | KIF20A | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: KIF20A (kinesin family member 20A)
Type: protein-coding
Summary: Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; intercellular bridge; and midbod... |
Does Knockout of CD1E in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | CD1E | response to virus | Cervical Adenocarcinoma Cell Line | Gene: CD1E (CD1e molecule)
Type: protein-coding
Summary: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presen... |
Does Knockout of CYP3A43 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | CYP3A43 | cell proliferation | Colorectal Cancer Cell Line | Gene: CYP3A43 (cytochrome P450 family 3 subfamily A member 43)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, s... |
Does Knockout of PFAS in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | PFAS | cell proliferation | acute lymphoblastic leukemia cell line | Gene: PFAS (phosphoribosylformylglycinamidine synthase)
Type: protein-coding
Summary: Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of p... |
Does Knockout of SSBP4 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | SSBP4 | response to chemicals | Monocytic Leukemia Cell Line | Gene: SSBP4 (single stranded DNA binding protein 4)
Type: protein-coding
Summary: Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be integral component of membrane. Predicted to be active in nuc... |
Does Knockout of MRPS18B in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | MRPS18B | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: MRPS18B (mitochondrial ribosomal protein S18B)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subuni... |
Does Knockout of ERVW-1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | ERVW-1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: ERVW-1 (endogenous retrovirus group W member 1, envelope)
Type: protein-coding
Summary: Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV... |
Does Knockout of LRIG2 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | LRIG2 | response to virus | Huh-7 Cell | Gene: LRIG2 (leucine rich repeats and immunoglobulin like domains 2)
Type: protein-coding
Summary: This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferat... |
Does Knockout of CDC14A in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | CDC14A | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: CDC14A (cell division cycle 14A)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and i... |
Does Knockout of TRAPPC8 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | TRAPPC8 | cell proliferation | Multiple Myeloma Cell Line | Gene: TRAPPC8 (trafficking protein particle complex subunit 8)
Type: protein-coding
Summary: Involved in Golgi organization. Part of TRAPP complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: COPII vesicle coating, Golgi organization, collagen biosynthetic process, e... |
Does Knockout of CYC1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | CYC1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: CYC1 (cytochrome c1)
Type: protein-coding
Summary: This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitocho... |
Does Knockout of KRTAP13-3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | KRTAP13-3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: KRTAP13-3 (keratin associated protein 13-3)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: Q... |
Does Knockout of CCDC174 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | CCDC174 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: CCDC174 (coiled-coil domain containing 174)
Type: protein-coding
Summary: The protein encoded by this gene is found in the nucleus, where it interacts with eukaryotic translation initiation factor 4A, isoform 3. The encoded protein appears to be a part of the exon junction complex, which is involv... |
Does Knockout of COL22A1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | COL22A1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: COL22A1 (collagen type XXII alpha 1 chain)
Type: protein-coding
Summary: This gene encodes member of the collagen family which is thought to contribute to the stabilization of myotendinous junctions and strengthen skeletal muscle attachments during contractile activity. It belongs to the fibril-as... |
Does Knockout of POMK in Hepatoma Cell Line causally result in cell proliferation? | 1 | 1,206 | Knockout | POMK | cell proliferation | Hepatoma Cell Line | Gene: POMK (protein O-mannose kinase)
Type: protein-coding
Summary: This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleto... |
Does Knockout of FDFT1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | FDFT1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Type: protein-coding
Summary: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two mole... |
Does Knockout of MIR4748 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | MIR4748 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: MIR4748 (microRNA 4748)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of FIP1L1 in Prostate Cancer Cell Line causally result in response to chemicals? | 1 | 2,109 | Knockout | FIP1L1 | response to chemicals | Prostate Cancer Cell Line | Gene: FIP1L1 (factor interacting with PAPOLA and CPSF1)
Type: protein-coding
Summary: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), b... |
Does Knockout of MRPL15 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | MRPL15 | response to chemicals | Monocytic Leukemia Cell Line | Gene: MRPL15 (mitochondrial ribosomal protein L15)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of LSM14A in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | LSM14A | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: LSM14A (LSM14A mRNA processing body assembly factor)
Type: protein-coding
Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions sepa... |
Does Knockout of AKIRIN2 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | AKIRIN2 | cell proliferation | Multiple Myeloma Cell Line | Gene: AKIRIN2 (akirin 2)
Type: protein-coding
Summary: Enables enzyme binding activity and identical protein binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within p... |
Does Knockout of TRAPPC13 in Prostate Cancer Cell Line causally result in response to chemicals? | 1 | 2,109 | Knockout | TRAPPC13 | response to chemicals | Prostate Cancer Cell Line | Gene: TRAPPC13 (trafficking protein particle complex subunit 13)
Type: protein-coding
Summary: Predicted to be located in cytosol. Predicted to be part of TRAPPIII protein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-med... |
Does Knockout of TNFRSF19 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | TNFRSF19 | cell proliferation | Melanoma Cell Line | Gene: TNFRSF19 (TNF receptor superfamily member 19)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK sign... |
Does Knockout of SSBP1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | SSBP1 | cell proliferation | Gastric Cancer Cell Line | Gene: SSBP1 (single stranded DNA binding protein 1)
Type: protein-coding
Summary: SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stabili... |
Does Knockout of EIF2A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | EIF2A | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: EIF2A (eukaryotic translation initiation factor 2A)
Type: protein-coding
Summary: This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrati... |
Does Knockout of DEFB103A in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | DEFB103A | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: DEFB103A (defensin beta 103A)
Type: protein-coding
Summary: Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an antibiotic peptide which is induced by bac... |
Does Activation of BRDT in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | BRDT | protein/peptide accumulation | T cell | Gene: BRDT (bromodomain testis associated)
Type: protein-coding
Summary: BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular d... |
Does Knockout of GALNT9 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | GALNT9 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: GALNT9 (polypeptide N-acetylgalactosaminyltransferase 9)
Type: protein-coding
Summary: This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi ... |
Does Knockout of RPL12 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | RPL12 | cell proliferation | Cancer Cell Line | Gene: RPL12 (ribosomal protein L12)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of BRIP1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | BRIP1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: BRIP1 (BRCA1 interacting DNA helicase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair functio... |
Does Knockout of ZNF559 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | ZNF559 | cell proliferation | Melanoma Cell Line | Gene: ZNF559 (zinc finger protein 559)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation ... |
Does Knockout of MRGBP in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | MRGBP | cell proliferation | Glioblastoma Cell Line | Gene: MRGBP (MRG domain binding protein)
Type: protein-coding
Summary: Predicted to be involved in histone acetylation and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, po... |
Does Knockout of ZNF471 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | ZNF471 | cell proliferation | Gastric Cancer Cell Line | Gene: ZNF471 (zinc finger protein 471)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of FAM111B in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | FAM111B | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: FAM111B (FAM111 trypsin like peptidase B)
Type: protein-coding
Summary: This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected ind... |
Does Knockout of FXYD5 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | FXYD5 | cell proliferation | Renal Cancer Cell Line | Gene: FXYD5 (FXYD domain containing ion transport regulator 5)
Type: protein-coding
Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino a... |
Does Knockout of ZWINT in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | ZWINT | response to chemicals | Monocytic Leukemia Cell Line | Gene: ZWINT (ZW10 interacting kinetochore protein)
Type: protein-coding
Summary: This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kin... |
Does Knockout of PAQR3 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | PAQR3 | cell proliferation | Hepatoma Cell Line | Gene: PAQR3 (progestin and adipoQ receptor family member 3)
Type: protein-coding
Summary: This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor... |
Does Knockout of RECK in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | RECK | cell proliferation | Breast Cancer Cell Line | Gene: RECK (reversion inducing cysteine rich protein with kazal motifs)
Type: protein-coding
Summary: The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various ki... |
Does Activation of TTC14 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | TTC14 | protein/peptide accumulation | T cell | Gene: TTC14 (tetratricopeptide repeat domain 14)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: Ectoderm Differentiation
UniProt: Q96N46
Entrez ID: 151613 |
Does Knockout of ZNF14 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | ZNF14 | cell proliferation | Cancer Cell Line | Gene: ZNF14 (zinc finger protein 14)
Type: protein-coding
Summary: The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. [provided by RefSeq, Jul 2008]... |
Does Knockout of IGBP1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | IGBP1 | cell proliferation | Glioblastoma Cell Line | Gene: IGBP1 (immunoglobulin binding protein 1)
Type: protein-coding
Summary: The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex... |
Does Knockout of MRPL27 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | MRPL27 | cell proliferation | Monocytic Leukemia Cell Line | Gene: MRPL27 (mitochondrial ribosomal protein L27)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of ALG12 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | ALG12 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ALG12 (ALG12 alpha-1,6-mannosyltransferase)
Type: protein-coding
Summary: This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Ma... |
Does Knockout of SLCO4A1 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | SLCO4A1 | cell proliferation | Multiple Myeloma Cell Line | Gene: SLCO4A1 (solute carrier organic anion transporter family member 4A1)
Type: protein-coding
Summary: Predicted to enable sodium-independent organic anion transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Predicted to be involved in sodium-independent organic ... |
Does Knockout of ELP1 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | ELP1 | response to chemicals | Monocytic Leukemia Cell Line | Gene: ELP1 (elongator acetyltransferase complex subunit 1)
Type: protein-coding
Summary: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases... |
Does Knockout of RPS28 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | RPS28 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: RPS28 (ribosomal protein S28)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of ISG20L2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | ISG20L2 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: ISG20L2 (interferon stimulated exonuclease gene 20 like 2)
Type: protein-coding
Summary: This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014].
Gene Ont... |
Does Knockout of MAGEA12 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | MAGEA12 | cell proliferation | Endometrial Cancer Cell Line | Gene: MAGEA12 (MAGE family member A12)
Type: protein-coding
Summary: This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun... |
Does Knockout of CFC1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | CFC1 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: CFC1 (cryptic, EGF-CFC family member 1)
Type: protein-coding
Summary: This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a c... |
Does Knockout of C11orf24 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | C11orf24 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: C11orf24 (chromosome 11 open reading frame 24)
Type: protein-coding
Summary: Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Golgi apparatus, membrane, nucleoplasm, plasma membrane
Pathways:
UniProt: Q9... |
Does Knockout of RNASEH2A in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | RNASEH2A | cell proliferation | acute lymphoblastic leukemia cell line | Gene: RNASEH2A (ribonuclease H2 subunit A)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotide... |
Does Knockout of CREBBP in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | CREBBP | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: CREBBP (CREB binding lysine acetyltransferase)
Type: protein-coding
Summary: This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CRE... |
Does Knockout of XKR3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | XKR3 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: XKR3 (XK related 3)
Type: protein-coding
Summary: XKRX (MIM 300684) and XKR3 are homologs of the Kell blood group precursor XK (MIM 314850), which is a putative membrane transporter and a component of the XK/Kell complex of the Kell blood group system (Calenda et al., 2006 [PubMed 16431037]).[supp... |
Does Knockout of ANKRD17 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | ANKRD17 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: ANKRD17 (ankyrin repeat domain 17)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyri... |
Does Knockout of ZNF433 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | ZNF433 | cell proliferation | Endometrial Cancer Cell Line | Gene: ZNF433 (zinc finger protein 433)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcrip... |
Does Knockout of USP5 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | USP5 | cell proliferation | Gastric Cancer Cell Line | Gene: USP5 (ubiquitin specific peptidase 5)
Type: protein-coding
Summary: Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal protei... |
Does Knockout of NOA1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | NOA1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: NOA1 (nitric oxide associated 1)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The e... |
Does Knockout of SATB2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | SATB2 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: SATB2 (SATB homeobox 2)
Type: protein-coding
Summary: This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft pal... |
Does Knockout of RPLP0 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | RPLP0 | cell proliferation | Medulloblastoma Cell Line | Gene: RPLP0 (ribosomal protein lateral stalk subunit P0)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct prote... |
Does Knockout of ZNF587 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | ZNF587 | cell proliferation | Ovarian Cancer Cell Line | Gene: ZNF587 (zinc finger protein 587)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of CUTC in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | CUTC | response to virus | Lung Cancer Cell Line | Gene: CUTC (cutC copper transporter)
Type: protein-coding
Summary: Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[sup... |
Does Knockout of LYPD1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | LYPD1 | cell proliferation | Medulloblastoma Cell Line | Gene: LYPD1 (LY6/PLAUR domain containing 1)
Type: protein-coding
Summary: Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to act upstream of or within several proces... |
Does Knockout of THAP9 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | THAP9 | response to chemicals | Melanoma Cell Line | Gene: THAP9 (THAP domain containing 9)
Type: protein-coding
Summary: Enables sequence-specific DNA binding activity and transposase activity. Involved in DNA integration and transposition, DNA-mediated. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA integration, DNA... |
Does Knockout of ANXA1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | ANXA1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: ANXA1 (annexin A1)
Type: protein-coding
Summary: This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq... |
Does Knockout of FHOD3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | FHOD3 | cell proliferation | Endometrial Cancer Cell Line | Gene: FHOD3 (formin homology 2 domain containing 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (... |
Does Knockout of CLCN5 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | CLCN5 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: CLCN5 (chloride voltage-gated channel 5)
Type: protein-coding
Summary: This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal t... |
Does Inhibition of EIF3H in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,184 | Inhibition | EIF3H | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: EIF3H (eukaryotic translation initiation factor 3 subunit H)
Type: protein-coding
Summary: Enables deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiati... |
Does Knockout of PPIL4 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | PPIL4 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: PPIL4 (peptidylprolyl isomerase like 4)
Type: protein-coding
Summary: This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and in... |
Does Knockout of NBAS in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | NBAS | cell proliferation | Monocytic Leukemia Cell Line | Gene: NBAS (NBAS subunit of NRZ tethering complex)
Type: protein-coding
Summary: This gene encodes a protein with two leucine zipper domains, a ribosomal protein S14 signature domain and a Sec39 like domain. The protein is thought to be involved in Golgi-to-ER transport. Mutations in this gene are assoc... |
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