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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of GEMIN4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
GEMIN4
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GEMIN4 (gem nuclear organelle associated protein 4)
Type: protein-coding
Summary: The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA processing, rRNA processing, spliceosomal snRNP assembly; MF: protein binding, ribonucleoprotein complex binding; CC: Cajal body, Gemini of Cajal bodies, SMN complex, SMN-Sm protein complex, cytoplasm, cytosol, extracellular exosome, membrane, nuclear body, nucleolus, nucleoplasm, nucleus, small nuclear ribonucleoprotein complex
Pathways: Disease, Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, RNA transport - Homo sapiens (human), SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, Viral Infection Pathways, snRNP Assembly
UniProt: P57678
Entrez ID: 50628
|
Does Knockout of WNT9B in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
WNT9B
|
cell proliferation
|
Cancer Cell Line
|
Gene: WNT9B (Wnt family member 9B)
Type: protein-coding
Summary: The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: Wnt signaling pathway, Wnt signaling pathway, planar cell polarity pathway, branching involved in ureteric bud morphogenesis, branching morphogenesis of an epithelial tube, canonical Wnt signaling pathway, cell fate commitment, cellular response to retinoic acid, cellular response to starvation, collecting duct development, cornea development in camera-type eye, embryonic cranial skeleton morphogenesis, establishment of planar polarity involved in nephron morphogenesis, in utero embryonic development, kidney development, kidney morphogenesis, kidney rudiment formation, male genitalia development, mesenchymal stem cell maintenance involved in nephron morphogenesis, mesonephric duct formation, mesonephric tubule development, metanephric tubule development, metanephric tubule formation, midbrain dopaminergic neuron differentiation, negative regulation of stem cell population maintenance, nephron tubule morphogenesis, neuron differentiation, non-canonical Wnt signaling pathway, regulation of asymmetric cell division, regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis, regulation of tube size, response to retinoic acid, roof of mouth development, uterus morphogenesis; MF: co-receptor binding, cytokine activity, frizzled binding, receptor ligand activity, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Alzheimer disease - Homo sapiens (human), Basal cell carcinoma - Homo sapiens (human), Breast cancer - Homo sapiens (human), Class B/2 (Secretin family receptors), Cushing syndrome - Homo sapiens (human), Developmental Biology, ESC Pluripotency Pathways, Epithelial to mesenchymal transition in colorectal cancer, GPCR ligand binding, Gastric cancer - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Kidney development, Melanogenesis - Homo sapiens (human), Nephron development, Osteoblast differentiation, Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), WNT ligand biogenesis and trafficking, Wnt signaling in kidney disease, Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, mTOR signaling pathway - Homo sapiens (human)
UniProt: O14905
Entrez ID: 7484
|
Does Knockout of ZNF622 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
ZNF622
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ZNF622 (zinc finger protein 622)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Located in Golgi apparatus; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intrinsic apoptotic signaling pathway in response to oxidative stress, positive regulation of JNK cascade, positive regulation of MAPK cascade, positive regulation of apoptotic process, positive regulation of kinase activity, ribosomal large subunit biogenesis, ribosome biogenesis; MF: RNA binding, metal ion binding, nucleic acid binding, preribosome binding, protein binding, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q969S3
Entrez ID: 90441
|
Does Knockout of ESRRA in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
ESRRA
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ESRRA (estrogen related receptor alpha)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019].
Gene Ontology: BP: intracellular receptor signaling pathway, negative regulation of transcription by RNA polymerase II, nuclear receptor-mediated steroid hormone signaling pathway, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, estrogen response element binding, metal ion binding, nuclear receptor activity, nuclear steroid receptor activity, protein binding, protein domain specific binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, steroid binding, zinc ion binding; CC: chromatin, cytoplasm, fibrillar center, intercellular bridge, microtubule cytoskeleton, nucleoplasm, nucleus
Pathways: Energy Metabolism, Gene expression (Transcription), Generic Transcription Pathway, Metabolism, Metabolism of lipids, Mitochondrial Gene Expression, Mitochondrial biogenesis, Nuclear Receptor transcription pathway, Nuclear receptors, Organelle biogenesis and maintenance, PPARA activates gene expression, Pre-implantation embryo, RNA Polymerase II Transcription, Regulation of RUNX2 expression and activity, Regulation of lipid metabolism by PPARalpha, Transcriptional activation of mitochondrial biogenesis, Transcriptional regulation by RUNX2, regulation of pgc-1a
UniProt: P11474
Entrez ID: 2101
|
Does Knockout of CWC27 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
CWC27
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: CWC27 (CWC27 spliceosome associated cyclophilin)
Type: protein-coding
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein peptidyl-prolyl isomerization. Located in nucleoplasm. Part of U2-type precatalytic spliceosome and catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mRNA splicing, via spliceosome, protein folding; MF: peptidyl-prolyl cis-trans isomerase activity, protein binding; CC: U2-type precatalytic spliceosome, catalytic step 2 spliceosome, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q6UX04
Entrez ID: 10283
|
Does Knockout of MUC15 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
MUC15
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MUC15 (mucin 15, cell surface associated)
Type: protein-coding
Summary: Predicted to be located in Golgi lumen and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Golgi lumen, extracellular region, membrane, plasma membrane
Pathways: C-type lectin receptors (CLRs), Dectin-2 family, Defective C1GALT1C1 causes TNPS, Defective GALNT12 causes CRCS1, Defective GALNT3 causes HFTC, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Immune System, Innate Immune System, Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, Termination of O-glycan biosynthesis
UniProt: Q8N387
Entrez ID: 143662
|
Does Knockout of GNB4 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
GNB4
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: GNB4 (G protein subunit beta 4)
Type: protein-coding
Summary: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction, substantia nigra development; MF: protein binding, protein-containing complex binding, signaling receptor complex adaptor activity; CC: cytoplasm, cytosol, extracellular exosome, heterotrimeric G-protein complex, lysosomal membrane, synapse
Pathways: ADORA2B mediated anti-inflammatory cytokines production, ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of G protein gated Potassium channels, Activation of GABAB receptors, Activation of kainate receptors upon glutamate binding, Adrenaline,noradrenaline inhibits insulin secretion, Alcoholism - Homo sapiens (human), Anti-inflammatory response favouring Leishmania parasite infection, Apelin signaling pathway - Homo sapiens (human), Aquaporin-mediated transport, Beta-catenin independent WNT signaling, Ca2+ pathway, Calcium Regulation in the Cardiac Cell, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chaperonin-mediated protein folding, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Class B/2 (Secretin family receptors), Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Disease, Dopaminergic synapse - Homo sapiens (human), ESR-mediated signaling, Extra-nuclear estrogen signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, G alpha (12/13) signalling events, G alpha (i) signalling events, G alpha (q) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G beta:gamma signalling through BTK, G beta:gamma signalling through CDC42, G beta:gamma signalling through PI3Kgamma, G beta:gamma signalling through PLC beta, G protein gated Potassium channels, G-protein activation, G-protein beta:gamma signalling, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Homo sapiens (human), GPCR downstream signalling, GPCR ligand binding, GPER1 signaling, Glucagon signaling in metabolic regulation, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Glutamatergic synapse - Homo sapiens (human), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Infectious disease, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Integration of energy metabolism, Inwardly rectifying K+ channels, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Leishmania infection, Leishmania parasite growth and survival, Metabolism, Metabolism of proteins, Morphine addiction - Homo sapiens (human), Myometrial relaxation and contraction pathways, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parasitic Infection Pathways, Pathways in cancer - Homo sapiens (human), Platelet activation, signaling and aggregation, Platelet homeostasis, Potassium Channels, Presynaptic function of Kainate receptors, Prostacyclin signalling through prostacyclin receptor, Protein folding, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of insulin secretion, Relaxin signaling pathway - Homo sapiens (human), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by WNT, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, Transmission across Chemical Synapses, Transport of small molecules, Vasopressin regulates renal water homeostasis via Aquaporins
UniProt: Q9HAV0
Entrez ID: 59345
|
Does Knockout of SNRPB2 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
SNRPB2
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: SNRPB2 (small nuclear ribonucleoprotein polypeptide B2)
Type: protein-coding
Summary: The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, U1 snRNA binding, nucleic acid binding, protein binding; CC: U1 snRNP, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, cytoplasmic ribonucleoprotein granule, fibrillar center, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex, spliceosomal snRNP complex
Pathways: Ciliary landscape, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, spliceosomal assembly
UniProt: P08579
Entrez ID: 6629
|
Does Knockout of HBEGF in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
HBEGF
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: HBEGF (heparin binding EGF like growth factor)
Type: protein-coding
Summary: Enables growth factor activity and heparin binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; and positive regulation of wound healing. Located in cell surface and extracellular space. Implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERBB2-EGFR signaling pathway, ERBB2-ERBB4 signaling pathway, cell chemotaxis, cell migration, epidermal growth factor receptor signaling pathway, muscle organ development, negative regulation of glycoprotein biosynthetic process, positive regulation of cell growth, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of keratinocyte migration, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of smooth muscle cell proliferation, positive regulation of wound healing, regulation of heart contraction, signal transduction, wound healing, spreading of epidermal cells; MF: epidermal growth factor receptor binding, growth factor activity, heparin binding, protein binding, receptor ligand activity, transmembrane receptor protein tyrosine kinase activator activity; CC: cell surface, clathrin-coated endocytic vesicle membrane, endocytic vesicle membrane, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Bacterial Infection Pathways, Bladder cancer, Bladder cancer - Homo sapiens (human), Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Constitutive Signaling by Aberrant PI3K in Cancer, Coronavirus disease - COVID-19 - Homo sapiens (human), Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downregulation of ERBB2 signaling, EGFR Transactivation by Gastrin, EGFR downregulation, EGFR interacts with phospholipase C-gamma, ERBB2 Activates PTK6 Signaling, ERBB2 Regulates Cell Motility, ESR-mediated signaling, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), ErbB receptor signaling network, ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), ErbB4 signaling events, Estrogen signaling pathway - Homo sapiens (human), Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Extra-nuclear estrogen signaling, G alpha (q) signalling events, GAB1 signalosome, GPCR downstream signalling, GRB2 events in EGFR signaling, GRB2 events in ERBB2 signaling, Gastrin-CREB signalling pathway via PKC and MAPK, GnRH signaling pathway - Homo sapiens (human), Hypertrophy Model, IL1 and megakaryocytes in obesity, Infectious disease, Inhibition of Signaling by Overexpressed EGFR, Intracellular signaling by second messengers, LPA receptor mediated events, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Membrane Trafficking, NRF2 pathway, Negative regulation of the PI3K/AKT network, Nuclear Receptors Meta-Pathway, Nuclear signaling by ERBB4, PI3K events in ERBB2 signaling, PI3K events in ERBB4 signaling, PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PTK6 promotes HIF1A stabilization, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Plasma membrane estrogen receptor signaling, Proteoglycans in cancer - Homo sapiens (human), RAF/MAP kinase cascade, SHC1 events in EGFR signaling, SHC1 events in ERBB2 signaling, SHC1 events in ERBB4 signaling, Signal Transduction, Signaling by EGFR, Signaling by EGFR in Cancer, Signaling by ERBB2, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 TMD/JMD mutants, Signaling by ERBB2 in Cancer, Signaling by ERBB4, Signaling by GPCR, Signaling by Non-Receptor Tyrosine Kinases, Signaling by Nuclear Receptors, Signaling by Overexpressed Wild-Type EGFR in Cancer, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Uptake and actions of bacterial toxins, Uptake and function of diphtheria toxin, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport, nfat and hypertrophy of the heart
UniProt: Q99075
Entrez ID: 1839
|
Does Knockout of EPCAM in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
EPCAM
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: EPCAM (epithelial cell adhesion molecule)
Type: protein-coding
Summary: This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008].
Gene Ontology: BP: cell-cell adhesion, negative regulation of cell-cell adhesion mediated by cadherin, positive regulation of cell population proliferation, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, signal transduction involved in regulation of gene expression, stem cell differentiation, ureteric bud development; MF: cadherin binding involved in cell-cell adhesion, protein binding, protein-containing complex binding; CC: anchoring junction, apical plasma membrane, basolateral plasma membrane, bicellular tight junction, cell surface, extracellular exosome, lateral plasma membrane, membrane, plasma membrane
Pathways: Attachment of bacteria to epithelial cells, Bacterial Infection Pathways, Biofilm formation, Cell surface interactions at the vascular wall, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Developmental Lineage of Mammary Gland Alveolar Cells, Developmental Lineage of Mammary Gland Luminal Epithelial Cells, Developmental Lineage of Mammary Gland Myoepithelial Cells, Developmental Lineage of Mammary Stem Cells, Developmental Lineages of the Mammary Gland, Disease, Hemostasis, Infection with Enterobacteria, Infectious disease
UniProt: P16422
Entrez ID: 4072
|
Does Knockout of MIR4313 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
MIR4313
|
response to virus
|
Hepatoma Cell Line
|
Gene: MIR4313 (microRNA 4313)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100423035
|
Does Knockout of ACTR2 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
ACTR2
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: ACTR2 (actin related protein 2)
Type: protein-coding
Summary: The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin cytoskeleton organization, asymmetric cell division, cellular response to type II interferon, cilium assembly, cytosolic transport, establishment or maintenance of cell polarity, meiotic cell cycle, meiotic chromosome movement towards spindle pole, meiotic cytokinesis, positive regulation of double-strand break repair via homologous recombination, positive regulation of lamellipodium assembly, positive regulation of transcription by RNA polymerase II, regulation of double-strand break repair via nonhomologous end joining, spindle localization; MF: ATP binding, actin binding, actin filament binding, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, actin cap, actin cytoskeleton, azurophil granule lumen, cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, focal adhesion, membrane, nucleus, site of double-strand break
Pathways: Association Between Physico-Chemical Features and Toxicity Associated Pathways, Axon guidance, Bacterial invasion of epithelial cells - Homo sapiens (human), CDC42 signaling events, Clathrin-mediated endocytosis, Developmental Biology, Disease, EGFR1, EPH-Ephrin signaling, EPHB-mediated forward signaling, ESC Pluripotency Pathways, Endocytosis - Homo sapiens (human), ErbB1 downstream signaling, FCGR3A-mediated phagocytosis, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania phagocytosis, Membrane Trafficking, Nervous system development, Neutrophil degranulation, PDGFR-beta signaling pathway, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), RAC1 signaling pathway, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Homo sapiens (human), Vesicle-mediated transport, Yersinia infection - Homo sapiens (human), how does salmonella hijack a cell, role of pi3k subunit p85 in regulation of actin organization and cell migration, y branching of actin filaments
UniProt: P61160
Entrez ID: 10097
|
Does Knockout of MDC1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 1
| 1,340
|
Knockout
|
MDC1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: MDC1 (mediator of DNA damage checkpoint 1)
Type: protein-coding
Summary: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication checkpoint signaling, chromatin organization, mitotic intra-S DNA damage checkpoint signaling, positive regulation of double-strand break repair via homologous recombination, protein K6-linked ubiquitination, protein localization to site of double-strand break; MF: chromatin-protein adaptor activity, histone reader activity, protein binding; CC: chromosome, focal adhesion, nuclear body, nucleoplasm, nucleus, site of double-strand break
Pathways: ATM Signaling Network in Development and Disease, ATM pathway, Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Metabolism of proteins, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, TP53 Regulates Transcription of DNA Repair Genes, Transcriptional Regulation by TP53
UniProt: Q14676
Entrez ID: 9656
|
Does Knockout of PRIM1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
PRIM1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PRIM1 (DNA primase subunit 1)
Type: protein-coding
Summary: The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, DNA replication initiation, DNA replication, synthesis of primer; MF: DNA-directed RNA polymerase activity, magnesium ion binding, metal ion binding, nucleotidyltransferase activity, protein binding, ribonucleotide binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, alpha DNA polymerase:primase complex, membrane, nucleoplasm
Pathways: Activation of the pre-replicative complex, Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA replication initiation, DNA strand elongation, Defective pyroptosis, Disease, Diseases of programmed cell death, E2F mediated regulation of DNA replication, Extension of Telomeres, G1 to S cell cycle control, G1/S Transition, Inhibition of replication initiation of damaged DNA by RB1/E2F1, Lagging Strand Synthesis, Leading Strand Synthesis, Mitotic G1 phase and G1/S transition, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the lagging strand, Pyrimidine metabolism, Removal of the Flap Intermediate, Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: P49642
Entrez ID: 5557
|
Does Knockout of GTF2A1 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
GTF2A1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: GTF2A1 (general transcription factor IIA subunit 1)
Type: protein-coding
Summary: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II general transcription initiation factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, TBP-class protein binding, protein binding, protein heterodimerization activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, transcription factor TFIIA complex, transcription factor TFIID complex, transcription preinitiation complex
Pathways: Basal transcription factors - Homo sapiens (human), Disease, ESR-mediated signaling, Estrogen-dependent gene expression, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by Nuclear Receptors, Transcription of the HIV genome, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), carm1 and regulation of the estrogen receptor, chromatin remodeling by hswi/snf atp-dependent complexes, the information processing pathway at the ifn beta enhancer
UniProt: P52655
Entrez ID: 2957
|
Does Knockout of HTRA2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
HTRA2
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: HTRA2 (HtrA serine peptidase 2)
Type: protein-coding
Summary: This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: adult locomotory behavior, adult walking behavior, apoptotic process, cellular response to growth factor stimulus, cellular response to heat, cellular response to interferon-beta, cellular response to oxidative stress, cellular response to retinoic acid, ceramide metabolic process, execution phase of apoptosis, forebrain development, intracellular signal transduction, intrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway in response to DNA damage, mitochondrial protein catabolic process, mitochondrion organization, negative regulation of cell cycle, negative regulation of neuron apoptotic process, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of type 2 mitophagy, neuron apoptotic process, neuron development, pentacyclic triterpenoid metabolic process, positive regulation of apoptotic process, positive regulation of execution phase of apoptosis, positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of protein targeting to mitochondrion, programmed cell death, protein autoprocessing, protein catabolic process, proteolysis, regulation of autophagy of mitochondrion, regulation of multicellular organism growth, response to herbicide; MF: hydrolase activity, identical protein binding, peptidase activity, protein binding, protein serine/threonine kinase inhibitor activity, serine-type endopeptidase activity, serine-type peptidase activity, ubiquitin ligase inhibitor activity, unfolded protein binding; CC: CD40 receptor complex, chromatin, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial intermembrane space, mitochondrial membrane, mitochondrion, nucleus, protein-containing complex, serine-type endopeptidase complex
Pathways: Apoptosis - Homo sapiens (human), Apoptosis - multiple species - Homo sapiens (human), Apoptosis Modulation and Signaling, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial unfolded protein response (UPRmt), Nanomaterial induced apoptosis, Parkinson disease - Homo sapiens (human), Parkinson,s disease pathway, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
UniProt: O43464
Entrez ID: 27429
|
Does Knockout of RANBP2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
RANBP2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RANBP2 (RAN binding protein 2)
Type: protein-coding
Summary: RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: NLS-bearing protein import into nucleus, centrosome localization, cytoplasmic pattern recognition receptor signaling pathway, mRNA transport, negative regulation of RNA export from nucleus, negative regulation of innate immune response, nuclear export, nucleocytoplasmic transport, protein folding, protein sumoylation, protein transport, regulation of gluconeogenesis, response to amphetamine, toll-like receptor signaling pathway; MF: GTPase activator activity, RNA binding, SUMO ligase activity, SUMO transferase activity, kinase activator activity, metal ion binding, peptidyl-prolyl cis-trans isomerase activity, protein binding, protein-containing complex binding, small GTPase binding, transferase activity, zinc ion binding; CC: SUMO ligase complex, annulate lamellae, cytoplasm, cytoplasmic periphery of the nuclear pore complex, cytosol, membrane, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear pore, nuclear pore cytoplasmic filaments, nuclear pore nuclear basket, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, EML4 and NUDC in mitotic spindle formation, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, role of ran in mitotic spindle regulation, snRNP Assembly, sumoylation by ranbp2 regulates transcriptional repression, tRNA processing, tRNA processing in the nucleus
UniProt: P49792
Entrez ID: 5903
|
Does Knockout of ABCA7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
ABCA7
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: ABCA7 (ATP binding cassette subfamily A member 7)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: amyloid-beta clearance by cellular catabolic process, amyloid-beta formation, apolipoprotein A-I-mediated signaling pathway, cholesterol efflux, high-density lipoprotein particle assembly, lipid transport, memory, negative regulation of MAPK cascade, negative regulation of PERK-mediated unfolded protein response, negative regulation of amyloid precursor protein biosynthetic process, negative regulation of amyloid-beta formation, negative regulation of endocytosis, phagocytosis, phospholipid efflux, phospholipid translocation, plasma membrane raft organization, positive regulation of ERK1 and ERK2 cascade, positive regulation of amyloid-beta clearance, positive regulation of cholesterol efflux, positive regulation of engulfment of apoptotic cell, positive regulation of phagocytosis, positive regulation of phospholipid efflux, positive regulation of protein localization to cell surface, protein localization to nucleus, regulation of amyloid precursor protein catabolic process, regulation of lipid metabolic process, transmembrane transport, visual learning; MF: ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, ATPase-coupled transmembrane transporter activity, apolipoprotein A-I receptor activity, floppase activity, nucleotide binding, phosphatidylcholine floppase activity, phosphatidylserine floppase activity, phospholipid transporter activity; CC: Golgi apparatus, Golgi membrane, cell junction, cell projection, cell surface, cytoplasm, early endosome membrane, endoplasmic reticulum, endosome, glial cell projection, intracellular membrane-bounded organelle, membrane, phagocytic cup, plasma membrane, ruffle membrane
Pathways: ABC transporters - Homo sapiens (human), ABC transporters in lipid homeostasis, ABC-family proteins mediated transport, Transport of small molecules
UniProt: Q8IZY2
Entrez ID: 10347
|
Does Knockout of MEGF9 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
MEGF9
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: MEGF9 (multiple EGF like domains 9)
Type: protein-coding
Summary: Predicted to be involved in several processes, including animal organ morphogenesis; cell migration; and substrate adhesion-dependent cell spreading. Predicted to be integral component of membrane. Predicted to be active in basement membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: basement membrane, membrane
Pathways:
UniProt: Q9H1U4
Entrez ID: 1955
|
Does Knockout of COPG1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
COPG1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: COPG1 (coat protein complex I subunit gamma 1)
Type: protein-coding
Summary: Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of Golgi localization, intra-Golgi vesicle-mediated transport, intracellular protein transport, organelle transport along microtubule, protein secretion, protein transport, vesicle-mediated transport; MF: protein binding, structural molecule activity; CC: COPI vesicle coat, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, membrane, membrane coat, organelle membrane, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport
UniProt: Q9Y678
Entrez ID: 22820
|
Does Knockout of RNASE1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
RNASE1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RNASE1 (ribonuclease A family member 1, pancreatic)
Type: protein-coding
Summary: This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: defense response to Gram-positive bacterium, defense response to virus; MF: RNA nuclease activity, endonuclease activity, hydrolase activity, lyase activity, nuclease activity, nucleic acid binding, protein binding, ribonuclease A activity; CC: extracellular exosome, extracellular region
Pathways: Autophagy, Chaperone Mediated Autophagy, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Pancreatic Acinar Cells, Late endosomal microautophagy
UniProt: P07998
Entrez ID: 6035
|
Does Knockout of GALNT6 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
GALNT6
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6)
Type: protein-coding
Summary: This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expressed in a fibroblast cell line, indicating that it may be involved in the synthesis of oncofetal fibronectin. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: protein O-linked glycosylation, protein O-linked glycosylation via N-acetyl-galactosamine, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane, perinuclear region of cytoplasm
Pathways: Metabolism of proteins, Mucin type O-glycan biosynthesis - Homo sapiens (human), O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Homo sapiens (human), Post-translational protein modification, mucin core 1 and core 2 <i>O</i>-glycosylation
UniProt: Q8NCL4
Entrez ID: 11226
|
Does Knockout of DMAP1 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
DMAP1
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: DMAP1 (DNA methyltransferase 1 associated protein 1)
Type: protein-coding
Summary: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA repair, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of protein import into nucleus, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, response to ethanol; MF: RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, transcription corepressor activity; CC: NuA4 histone acetyltransferase complex, Swr1 complex, chromosome, cytoplasm, cytosol, nucleoplasm, nucleosome, nucleus, replication fork
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9NPF5
Entrez ID: 55929
|
Does Knockout of NAPG in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
NAPG
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: NAPG (NSF attachment protein gamma)
Type: protein-coding
Summary: This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008].
Gene Ontology: BP: intra-Golgi vesicle-mediated transport, intracellular protein transport, membrane fusion, protein stabilization, protein transport, protein-containing complex assembly, vesicle-mediated transport; MF: protein binding, soluble NSF attachment protein activity, syntaxin binding; CC: Golgi apparatus, SNARE complex, extracellular exosome, lysosomal membrane, membrane, mitochondrion
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q99747
Entrez ID: 8774
|
Does Knockout of CAP1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
CAP1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CAP1 (cyclase associated actin cytoskeleton regulatory protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: actin cytoskeleton organization, actin filament organization, activation of adenylate cyclase activity, ameboidal-type cell migration, cAMP-mediated signaling, cell morphogenesis, cytoskeleton organization, establishment or maintenance of cell polarity, modification of postsynaptic actin cytoskeleton, receptor-mediated endocytosis, signal transduction; MF: actin binding, adenylate cyclase binding, protein binding; CC: azurophil granule lumen, cortical actin cytoskeleton, cytoplasm, extracellular exosome, extracellular region, focal adhesion, glutamatergic synapse, membrane, plasma membrane, postsynapse, presynapse
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, Axon guidance, Developmental Biology, Hemostasis, Immune System, Innate Immune System, Insulin Signaling, Nervous system development, Neutrophil degranulation, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+, Role of ABL in ROBO-SLIT signaling, Signaling by ROBO receptors, how progesterone initiates the oocyte maturation
UniProt: Q01518
Entrez ID: 10487
|
Does Knockout of FAM162A in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
FAM162A
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: FAM162A (family with sequence similarity 162 member A)
Type: protein-coding
Summary: Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to hypoxia; and positive regulation of release of cytochrome c from mitochondria. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, cellular response to hypoxia, neuron apoptotic process, positive regulation of apoptotic process, positive regulation of release of cytochrome c from mitochondria; CC: cytosol, membrane, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q96A26
Entrez ID: 26355
|
Does Knockout of CFAP126 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
CFAP126
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CFAP126 (cilia and flagella associated protein 126)
Type: protein-coding
Summary: Predicted to be involved in cilium organization. Predicted to be located in apical plasma membrane and cilium. Predicted to be active in ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell projection organization, cilium organization, flagellated sperm motility; CC: apical plasma membrane, axonemal B tubule inner sheath, axonemal microtubule, cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, membrane, motile cilium, plasma membrane, sperm flagellum
Pathways:
UniProt: Q5VTH2
Entrez ID: 257177
|
Does Knockout of PAQR4 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
PAQR4
|
response to virus
|
Lung Cancer Cell Line
|
Gene: PAQR4 (progestin and adipoQ receptor family member 4)
Type: protein-coding
Summary: Predicted to enable signaling receptor activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein stabilization, regulation of ceramide biosynthetic process; MF: molecular adaptor activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways:
UniProt: Q8N4S7
Entrez ID: 124222
|
Does Knockout of DKK1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
DKK1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: DKK1 (dickkopf Wnt signaling pathway inhibitor 1)
Type: protein-coding
Summary: This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017].
Gene Ontology: BP: Wnt signaling pathway, Wnt signaling pathway involved in somitogenesis, canonical Wnt signaling pathway, cell morphogenesis, embryonic limb morphogenesis, endocardial cushion development, endoderm development, endoderm formation, face morphogenesis, forebrain development, hair follicle development, head morphogenesis, heart induction, heart valve development, learning or memory, limb development, mesoderm formation, motor learning, negative regulation of BMP signaling pathway, negative regulation of SMAD protein signal transduction, negative regulation of Wnt signaling pathway, negative regulation of Wnt-Frizzled-LRP5/6 complex assembly, negative regulation of apoptotic process, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle cell differentiation, negative regulation of mesodermal cell fate specification, negative regulation of neuron projection development, negative regulation of ossification, negative regulation of presynapse assembly, negative regulation of transcription by RNA polymerase II, positive regulation of JNK cascade, positive regulation of Wnt signaling pathway, calcium modulating pathway, positive regulation of Wnt signaling pathway, planar cell polarity pathway, positive regulation of gene expression, positive regulation of midbrain dopaminergic neuron differentiation, regulation of Wnt signaling pathway, regulation of dopaminergic neuron differentiation, regulation of endodermal cell fate specification, regulation of neuron apoptotic process, regulation of receptor internalization, regulation of synapse organization, regulation of synaptic transmission, glutamatergic, response to retinoic acid, synapse pruning; MF: co-receptor binding, growth factor activity, low-density lipoprotein particle receptor binding, protein binding, receptor antagonist activity; CC: early endosome membrane, extracellular region, extracellular space, plasma membrane
Pathways: Alzheimer disease - Homo sapiens (human), Cardiac Progenitor Differentiation, Differentiation Pathway, Direct p53 effectors, Disease, Diseases of signal transduction by growth factor receptors and second messengers, EDA signaling in hair follicle development, Endoderm differentiation, LncRNA involvement in canonical Wnt signaling and colorectal cancer, Mesodermal commitment pathway, Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Presenilin action in Notch and Wnt signaling, Primary focal segmental glomerulosclerosis (FSGS), Regulation of nuclear beta catenin signaling and target gene transcription, Role of Osx and miRNAs in tooth development, Signal Transduction, Signaling by LRP5 mutants , Signaling by WNT, Signaling by WNT in cancer, TCF dependent signaling in response to WNT, VEGFA-VEGFR2 Signaling Pathway, Validated targets of C-MYC transcriptional repression, Wnt, Wnt signaling, Wnt signaling network, Wnt signaling pathway - Homo sapiens (human), Wnt-beta-catenin signaling pathway in leukemia, inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages, multi-step regulation of transcription by pitx2, ncRNAs involved in Wnt signaling in hepatocellular carcinoma, segmentation clock, wnt lrp6 signalling, wnt signaling pathway
UniProt: O94907
Entrez ID: 22943
|
Does Knockout of NMNAT1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
NMNAT1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: NMNAT1 (nicotinamide nucleotide adenylyltransferase 1)
Type: protein-coding
Summary: This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: ATP generation from poly-ADP-D-ribose, NAD+ biosynthetic process, NAD+ biosynthetic process via the salvage pathway, negative regulation of DNA-templated transcription, negative regulation of adipose tissue development, negative regulation of apoptotic DNA fragmentation, negative regulation of neuron apoptotic process, nicotinamide metabolic process, nucleotide biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of adipose tissue development, purine nucleotide metabolic process, pyridine nucleotide biosynthetic process, response to wounding; MF: ATP binding, catalytic activity, identical protein binding, nicotinamide-nucleotide adenylyltransferase activity, nicotinate-nucleotide adenylyltransferase activity, nucleotide binding, nucleotidyltransferase activity, protein ADP-ribosyltransferase-substrate adaptor activity, protein binding, transferase activity; CC: chromatin, nuclear body, nucleoplasm, nucleus
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, NAD <i>de novo</i> biosynthesis, NAD Biosynthesis II (from tryptophan), NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde, NAD salvage, NAD+ biosynthetic pathways, NAD+ metabolism, Nicotinate and nicotinamide metabolism - Homo sapiens (human), Nicotinate metabolism, superpathway of tryptophan utilization
UniProt: Q9HAN9
Entrez ID: 64802
|
Does Knockout of RASL10B in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
RASL10B
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: RASL10B (RAS like family 10 member B)
Type: protein-coding
Summary: Predicted to enable G protein activity and GTP binding activity. Predicted to be involved in positive regulation of peptide hormone secretion and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of peptide hormone secretion, regulation of systemic arterial blood pressure by atrial natriuretic peptide; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding; CC: membrane, plasma membrane
Pathways:
UniProt: Q96S79
Entrez ID: 91608
|
Does Knockout of KIF20A in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
KIF20A
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: KIF20A (kinesin family member 20A)
Type: protein-coding
Summary: Enables protein kinase binding activity. Involved in microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Located in several cellular components, including cleavage furrow; intercellular bridge; and midbody. Implicated in restrictive cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: microtubule bundle formation, microtubule-based movement, midbody abscission, mitotic cytokinesis, protein transport, regulation of cytokinesis; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, nucleotide binding, protein binding, protein kinase binding; CC: Golgi apparatus, cleavage furrow, cytoplasm, cytoskeleton, intercellular bridge, kinesin complex, microtubule, midbody, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: Adaptive Immune System, Aurora B signaling, COPI-dependent Golgi-to-ER retrograde traffic, Cell Cycle, Cell Cycle, Mitotic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, M Phase, MHC class II antigen presentation, Membrane Trafficking, Mitotic Telophase/Cytokinesis, PLK1 signaling events, Vesicle-mediated transport
UniProt: O95235
Entrez ID: 10112
|
Does Knockout of CD1E in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
CD1E
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: CD1E (CD1e molecule)
Type: protein-coding
Summary: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: adaptive immune response, antigen processing and presentation, endogenous lipid antigen via MHC class Ib, antigen processing and presentation, exogenous lipid antigen via MHC class Ib, immune response, immune system process, positive regulation of T cell mediated cytotoxicity; MF: endogenous lipid antigen binding, exogenous lipid antigen binding, lipid binding, lipopeptide binding; CC: Golgi apparatus, Golgi membrane, early endosome, endosome, external side of plasma membrane, extracellular space, late endosome, lysosomal lumen, lysosome, membrane, nucleolus, plasma membrane
Pathways: Amoebiasis - Homo sapiens (human), Hematopoietic cell lineage - Homo sapiens (human), Tight junction - Homo sapiens (human)
UniProt: P15812
Entrez ID: 913
|
Does Knockout of CYP3A43 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
CYP3A43
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: CYP3A43 (cytochrome P450 family 3 subfamily A member 43)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: cytochrome metabolic process, oxidative demethylation, steroid metabolic process; MF: estrogen 16-alpha-hydroxylase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, testosterone 6-beta-hydroxylase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Aripiprazole Metabolic Pathway, Biological oxidations, Chemical carcinogenesis - Homo sapiens (human), Cytochrome P450 - arranged by substrate type, Metabolism, Metapathway biotransformation Phase I and II, Miscellaneous substrates, Oxidation by Cytochrome P450, Phase I - Functionalization of compounds, Retinol Metabolism, Vitamin A Deficiency, Xenobiotics
UniProt: Q9HB55
Entrez ID: 64816
|
Does Knockout of PFAS in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
PFAS
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: PFAS (phosphoribosylformylglycinamidine synthase)
Type: protein-coding
Summary: Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, anterior head development, glutamine metabolic process, purine nucleotide biosynthetic process, purine ribonucleoside monophosphate biosynthetic process, response to xenobiotic stimulus; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, phosphoribosylformylglycinamidine synthase activity; CC: cytoplasm, cytosol, extracellular exosome
Pathways: 5-aminoimidazole ribonucleotide biosynthesis, AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Gout or Kelley-Seegmiller Syndrome, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide biosynthesis, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Purine ribonucleoside monophosphate biosynthesis, Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, purine nucleotides <i>de novo</i> biosynthesis
UniProt: O15067
Entrez ID: 5198
|
Does Knockout of SSBP4 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
SSBP4
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: SSBP4 (single stranded DNA binding protein 4)
Type: protein-coding
Summary: Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be integral component of membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, protein binding, single-stranded DNA binding; CC: nucleus
Pathways:
UniProt: Q9BWG4
Entrez ID: 170463
|
Does Knockout of MRPS18B in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
MRPS18B
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MRPS18B (mitochondrial ribosomal protein S18B)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: protein binding, structural constituent of ribosome; CC: cell junction, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation, Viral carcinogenesis - Homo sapiens (human)
UniProt: Q9Y676
Entrez ID: 28973
|
Does Knockout of ERVW-1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
ERVW-1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: ERVW-1 (endogenous retrovirus group W member 1, envelope)
Type: protein-coding
Summary: Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: anatomical structure morphogenesis, myoblast fusion, syncytium formation, syncytium formation by plasma membrane fusion; CC: membrane, plasma membrane
Pathways:
UniProt: Q9UQF0
Entrez ID: 30816
|
Does Knockout of LRIG2 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
LRIG2
|
response to virus
|
Huh-7 Cell
|
Gene: LRIG2 (leucine rich repeats and immunoglobulin like domains 2)
Type: protein-coding
Summary: This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: innervation, membrane protein ectodomain proteolysis, negative regulation of axon regeneration, negative regulation of membrane protein ectodomain proteolysis, negative regulation of neuron projection development, positive regulation of protein localization to cell surface, protein localization to cell surface, regulation of axon regeneration, regulation of neuron migration, regulation of platelet-derived growth factor receptor signaling pathway, sensory perception of sound; MF: protein binding, signaling receptor activity, signaling receptor binding; CC: cytoplasm, growth cone, intracellular vesicle, membrane, plasma membrane
Pathways: Axon guidance - Homo sapiens (human)
UniProt: O94898
Entrez ID: 9860
|
Does Knockout of CDC14A in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
CDC14A
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: CDC14A (cell division cycle 14A)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell division, cilium assembly, microtubule cytoskeleton organization, positive regulation of cytokinesis, regulation of exit from mitosis, sensory perception of sound; MF: hydrolase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity; CC: cell projection, centrosome, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum, kinociliary basal body, kinocilium, microtubule organizing center, mitotic spindle, nucleolus, nucleoplasm, nucleus, spindle, spindle pole, stereocilium, stereocilium tip
Pathways: APC/C-mediated degradation of cell cycle proteins, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, MAPK family signaling cascades, MAPK6/MAPK4 signaling, Regulation of mitotic cell cycle, Signal Transduction
UniProt: Q9UNH5
Entrez ID: 8556
|
Does Knockout of TRAPPC8 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
TRAPPC8
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: TRAPPC8 (trafficking protein particle complex subunit 8)
Type: protein-coding
Summary: Involved in Golgi organization. Part of TRAPP complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: COPII vesicle coating, Golgi organization, collagen biosynthetic process, endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, TRAPP complex, TRAPPIII protein complex, cytoplasm, cytosol
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q9Y2L5
Entrez ID: 22878
|
Does Knockout of CYC1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
CYC1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CYC1 (cytochrome c1)
Type: protein-coding
Summary: This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: cellular respiration, mitochondrial electron transport, ubiquinol to cytochrome c, proton transmembrane transport, response to glucagon; MF: electron transfer activity, heme binding, metal ion binding, protein binding, quinol-cytochrome-c reductase activity; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleus, respiratory chain complex III
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Complex III assembly, Diabetic cardiomyopathy - Homo sapiens (human), Huntington disease - Homo sapiens (human), Metabolism, Mitochondrial complex III assembly, Mitochondrial protein import, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Protein localization, Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: P08574
Entrez ID: 1537
|
Does Knockout of KRTAP13-3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
KRTAP13-3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: KRTAP13-3 (keratin associated protein 13-3)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: Q3SY46
Entrez ID: 337960
|
Does Knockout of CCDC174 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
CCDC174
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: CCDC174 (coiled-coil domain containing 174)
Type: protein-coding
Summary: The protein encoded by this gene is found in the nucleus, where it interacts with eukaryotic translation initiation factor 4A, isoform 3. The encoded protein appears to be a part of the exon junction complex, which is involved in RNA processing, translation, and nonsense-mediated mRNA decay. A mutation in this gene has been associated with infantile hypotonia with psychomotor retardation. [provided by RefSeq, Mar 2016].
Gene Ontology: CC: nucleoplasm, nucleus
Pathways:
UniProt: Q6PII3
Entrez ID: 51244
|
Does Knockout of COL22A1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
COL22A1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: COL22A1 (collagen type XXII alpha 1 chain)
Type: protein-coding
Summary: This gene encodes member of the collagen family which is thought to contribute to the stabilization of myotendinous junctions and strengthen skeletal muscle attachments during contractile activity. It belongs to the fibril-associated collagens with interrupted triple helix (FACIT) subset of the collagen superfamily, which associate with collagen fibers through their C-terminal collagenous domains and mediate protein-protein interactions through their N-terminal noncollagenous domains. The encoded protein is deposited in the basement membrane zone of the myotendinous junction which is present only at the tissue junctions of muscles, tendons, the heart, articular cartilage, and skin. A knockdown of the orthologous zebrafish gene induces a muscular dystrophy by disruption of the myotendinous junction. [provided by RefSeq, May 2017].
Gene Ontology: CC: basement membrane, collagen trimer, cytoplasm, endoplasmic reticulum lumen, extracellular region
Pathways: Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen formation, Extracellular matrix organization, Protein digestion and absorption - Homo sapiens (human)
UniProt: Q8NFW1
Entrez ID: 169044
|
Does Knockout of POMK in Hepatoma Cell Line causally result in cell proliferation?
| 1
| 1,206
|
Knockout
|
POMK
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: POMK (protein O-mannose kinase)
Type: protein-coding
Summary: This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].
Gene Ontology: BP: brain development, carbohydrate phosphorylation, learning or memory, neuromuscular process, protein O-linked glycosylation, sensory perception of pain; MF: ATP binding, carbohydrate kinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein binding, protein kinase activity, transferase activity, transferase activity, transferring phosphorus-containing groups; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: DAG1 core M3 glycosylations, DAG1 glycosylations, Mannose type O-glycan biosynthesis - Homo sapiens (human), Metabolism of proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q9H5K3
Entrez ID: 84197
|
Does Knockout of FDFT1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
FDFT1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Type: protein-coding
Summary: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol metabolic process, farnesyl diphosphate metabolic process, lipid biosynthetic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: catalytic activity, metal ion binding, protein binding, squalene synthase [NAD(P)H] activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Activation of gene expression by SREBF (SREBP), Alendronate Action Pathway, Atorvastatin Action Pathway, CHILD Syndrome, Cerivastatin Action Pathway, Cholesterol Biosynthesis Pathway, Cholesterol biosynthesis, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Cholesteryl ester storage disease, Chondrodysplasia Punctata II, X Linked Dominant (CDPX2), Desmosterolosis, Fluvastatin Action Pathway, Hyper-IgD syndrome, Hypercholesterolemia, Ibandronate Action Pathway, Lovastatin Action Pathway, Lysosomal Acid Lipase Deficiency (Wolman Disease), Metabolism, Metabolism of lipids, Metabolism of steroids, Mevalonic aciduria, PPARA activates gene expression, Pamidronate Action Pathway, Pravastatin Action Pathway, Regulation of cholesterol biosynthesis by SREBP (SREBF), Regulation of lipid metabolism by PPARalpha, Risedronate Action Pathway, Rosuvastatin Action Pathway, Simvastatin Action Pathway, Smith-Lemli-Opitz Syndrome (SLOS), Statin inhibition of cholesterol production, Steroid Biosynthesis, Steroid biosynthesis - Homo sapiens (human), Sterol regulatory element-binding proteins (SREBP) signaling, Wolman disease, Zoledronate Action Pathway, cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), epoxysqualene biosynthesis, superpathway of cholesterol biosynthesis
UniProt: P37268
Entrez ID: 2222
|
Does Knockout of MIR4748 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
MIR4748
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: MIR4748 (microRNA 4748)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100616425
|
Does Knockout of FIP1L1 in Prostate Cancer Cell Line causally result in response to chemicals?
| 1
| 2,109
|
Knockout
|
FIP1L1
|
response to chemicals
|
Prostate Cancer Cell Line
|
Gene: FIP1L1 (factor interacting with PAPOLA and CPSF1)
Type: protein-coding
Summary: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].
Gene Ontology: MF: RNA binding, protein binding; CC: cytosol, mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Disease, Diseases of signal transduction by growth factor receptors and second messengers, Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Signaling by PDGFR in disease, Signaling by cytosolic PDGFRA and PDGFRB fusion proteins, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q6UN15
Entrez ID: 81608
|
Does Knockout of MRPL15 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
MRPL15
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: MRPL15 (mitochondrial ribosomal protein L15)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9P015
Entrez ID: 29088
|
Does Knockout of LSM14A in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
LSM14A
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: LSM14A (LSM14A mRNA processing body assembly factor)
Type: protein-coding
Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008].
Gene Ontology: BP: P-body assembly, RIG-I signaling pathway, defense response to virus, mitotic spindle assembly, negative regulation of translation, positive regulation of type I interferon-mediated signaling pathway, regulation of translation, stress granule assembly; MF: RNA binding, double-stranded DNA binding, double-stranded RNA binding, mRNA binding, protein binding, single-stranded RNA binding; CC: P-body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytoskeleton, cytosol, mitotic spindle, ribonucleoprotein complex, spindle
Pathways:
UniProt: Q8ND56
Entrez ID: 26065
|
Does Knockout of AKIRIN2 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
AKIRIN2
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: AKIRIN2 (akirin 2)
Type: protein-coding
Summary: Enables enzyme binding activity and identical protein binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of interleukin-6 production and response to lipopolysaccharide. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: adaptive immune response, cerebral cortex development, defense response to bacterium, embryo development ending in birth or egg hatching, immune system process, innate immune response, nuclear protein quality control by the ubiquitin-proteasome system, positive regulation of B cell activation, positive regulation of adaptive immune response, positive regulation of innate immune response, positive regulation of interleukin-6 production, positive regulation of transcription by RNA polymerase II, proteasomal protein catabolic process, proteasome localization, protein import into nucleus, protein transport, regulation of muscle cell differentiation, response to lipopolysaccharide; MF: enzyme binding, identical protein binding, protein binding, protein-macromolecule adaptor activity, transcription coregulator activity; CC: chromatin, cytoplasm, membrane, nucleoplasm, nucleus, transcription repressor complex
Pathways:
UniProt: Q53H80
Entrez ID: 55122
|
Does Knockout of TRAPPC13 in Prostate Cancer Cell Line causally result in response to chemicals?
| 1
| 2,109
|
Knockout
|
TRAPPC13
|
response to chemicals
|
Prostate Cancer Cell Line
|
Gene: TRAPPC13 (trafficking protein particle complex subunit 13)
Type: protein-coding
Summary: Predicted to be located in cytosol. Predicted to be part of TRAPPIII protein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering; CC: TRAPPII protein complex, TRAPPIII protein complex, cytoplasm, cytosol
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: A5PLN9
Entrez ID: 80006
|
Does Knockout of TNFRSF19 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
TNFRSF19
|
cell proliferation
|
Melanoma Cell Line
|
Gene: TNFRSF19 (TNF receptor superfamily member 19)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: JNK cascade, apoptotic process, hair follicle development, positive regulation of JNK cascade, positive regulation of canonical NF-kappaB signal transduction, tumor necrosis factor-mediated signaling pathway; MF: protein binding, signaling receptor activity, tumor necrosis factor receptor activity; CC: membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human)
UniProt: Q9NS68
Entrez ID: 55504
|
Does Knockout of SSBP1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
SSBP1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SSBP1 (single stranded DNA binding protein 1)
Type: protein-coding
Summary: SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010].
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, positive regulation of helicase activity, positive regulation of mitochondrial DNA replication, protein homotetramerization; MF: DNA binding, RNA binding, chromatin binding, enzyme activator activity, identical protein binding, protein binding, protein homodimerization activity, single-stranded DNA binding; CC: extracellular exosome, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleus
Pathways: DNA Replication, DNA replication - Homo sapiens (human), Homologous recombination - Homo sapiens (human), Metabolism of proteins, Mismatch repair - Homo sapiens (human), Mitochondrial biogenesis, Mitochondrial protein degradation, Organelle biogenesis and maintenance, Strand-asynchronous mitochondrial DNA replication, Transcriptional activation of mitochondrial biogenesis
UniProt: Q04837
Entrez ID: 6742
|
Does Knockout of EIF2A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
EIF2A
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: EIF2A (eukaryotic translation initiation factor 2A)
Type: protein-coding
Summary: This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: SREBP signaling pathway, positive regulation of signal transduction, regulation of translation, response to amino acid starvation, ribosome assembly, translation, translational initiation; MF: cadherin binding, mRNA binding, protein binding, ribosome binding, tRNA binding, translation initiation factor activity; CC: blood microparticle, cytoplasm, eukaryotic translation initiation factor 2 complex, extracellular space
Pathways: Ceramide signaling pathway, IL6, Photodynamic therapy-induced unfolded protein response, Signaling events mediated by TCPTP, TGF-beta receptor signaling, VEGFA-VEGFR2 Signaling Pathway
UniProt: Q9BY44
Entrez ID: 83939
|
Does Knockout of DEFB103A in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
DEFB103A
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: DEFB103A (defensin beta 103A)
Type: protein-coding
Summary: Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cell chemotaxis, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, defense response to symbiont, killing by host of symbiont cells, killing of cells of another organism, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity, protein binding; CC: Golgi lumen, extracellular region, extracellular space
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System, NOD-like receptor signaling pathway - Homo sapiens (human), Staphylococcus aureus infection - Homo sapiens (human)
UniProt: P81534
Entrez ID: 414325
|
Does Activation of BRDT in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
BRDT
|
protein/peptide accumulation
|
T cell
|
Gene: BRDT (bromodomain testis associated)
Type: protein-coding
Summary: BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: RNA splicing, cell differentiation, chromatin organization, chromatin remodeling, mRNA processing, male meiosis I, male meiotic nuclear division, meiotic cell cycle, positive regulation of DNA-templated transcription, positive regulation of gene expression, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of transcription by RNA polymerase II, sperm DNA condensation, spermatogenesis; MF: chromatin binding, histone H4 reader activity, histone binding, protein serine/threonine kinase activity, protein-macromolecule adaptor activity, transcription coactivator activity; CC: chromatin, nucleus
Pathways: Male infertility
UniProt: Q58F21
Entrez ID: 676
|
Does Knockout of GALNT9 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
GALNT9
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: GALNT9 (polypeptide N-acetylgalactosaminyltransferase 9)
Type: protein-coding
Summary: This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. This gene is expressed specifically in the brain, with highest expression in the cerebellum. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: protein O-linked glycosylation, protein O-linked glycosylation via N-acetyl-galactosamine, protein glycosylation; MF: carbohydrate binding, glycosyltransferase activity, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Metabolism of proteins, Mucin type O-glycan biosynthesis - Homo sapiens (human), O-linked glycosylation, O-linked glycosylation of mucins, Other types of O-glycan biosynthesis - Homo sapiens (human), Post-translational protein modification, mucin core 1 and core 2 <i>O</i>-glycosylation
UniProt: Q9HCQ5
Entrez ID: 50614
|
Does Knockout of RPL12 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
RPL12
|
cell proliferation
|
Cancer Cell Line
|
Gene: RPL12 (ribosomal protein L12)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, large ribosomal subunit rRNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, membrane, postsynaptic density, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P30050
Entrez ID: 6136
|
Does Knockout of BRIP1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
BRIP1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: BRIP1 (BRCA1 interacting DNA helicase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, chiasma assembly, double-strand break repair, double-strand break repair involved in meiotic recombination, homologous chromosome pairing at meiosis, homologous recombination, interstrand cross-link repair, male gonad development, meiotic DNA double-strand break processing involved in reciprocal meiotic recombination, nucleobase-containing compound metabolic process, nucleotide-excision repair, protein-DNA covalent cross-linking repair, regulation of transcription by RNA polymerase II, seminiferous tubule development, spermatid development, spermatogenesis, spermatogonial cell division; MF: 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, RNA helicase activity, catalytic activity, acting on a nucleic acid, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, iron-sulfur cluster binding, isomerase activity, metal ion binding, nucleic acid binding, nucleotide binding, protein binding; CC: BRCA1-B complex, cytoplasm, nuclear membrane, nucleoplasm, nucleus, replication fork
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cytosolic iron-sulfur cluster assembly, DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Defective homologous recombination repair (HRR) due to BRCA1 loss of function, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Defective homologous recombination repair (HRR) due to PALB2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Fanconi anemia pathway, Fanconi anemia pathway - Homo sapiens (human), G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to PALB2, Impaired BRCA2 binding to RAD51, Metabolism, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), Transcriptional Regulation by TP53
UniProt: Q9BX63
Entrez ID: 83990
|
Does Knockout of ZNF559 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
ZNF559
|
cell proliferation
|
Melanoma Cell Line
|
Gene: ZNF559 (zinc finger protein 559)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9BR84
Entrez ID: 84527
|
Does Knockout of MRGBP in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
MRGBP
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: MRGBP (MRG domain binding protein)
Type: protein-coding
Summary: Predicted to be involved in histone acetylation and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, regulation of transcription by RNA polymerase II; CC: H4/H2A histone acetyltransferase complex, NuA4 histone acetyltransferase complex, nucleoplasm, nucleosome, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9NV56
Entrez ID: 55257
|
Does Knockout of ZNF471 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
ZNF471
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ZNF471 (zinc finger protein 471)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9BX82
Entrez ID: 57573
|
Does Knockout of FAM111B in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
FAM111B
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: FAM111B (FAM111 trypsin like peptidase B)
Type: protein-coding
Summary: This gene encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A paralog of this gene which also has a trypsin‐like peptidase domain, FAM111A, is located only 16 kb from this gene on human chromosome 11q12.1. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: DNA replication, proteolysis; MF: hydrolase activity, peptidase activity, protein binding, serine-type peptidase activity; CC: chromatin, cytoplasm, nuclear lamina, nucleus
Pathways:
UniProt: Q6SJ93
Entrez ID: 374393
|
Does Knockout of FXYD5 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
FXYD5
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: FXYD5 (FXYD domain containing ion transport regulator 5)
Type: protein-coding
Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009].
Gene Ontology: BP: microvillus assembly, monoatomic ion transport, negative regulation of calcium-dependent cell-cell adhesion, positive regulation of sodium ion export across plasma membrane, potassium ion transport, regulation of monoatomic ion transport, sodium ion transport; MF: actin binding, cadherin binding, ion channel regulator activity, protein binding, sodium channel regulator activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q96DB9
Entrez ID: 53827
|
Does Knockout of ZWINT in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
ZWINT
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: ZWINT (ZW10 interacting kinetochore protein)
Type: protein-coding
Summary: This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell division, establishment of localization in cell, homologous chromosome orientation in meiotic metaphase I, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, regulation of meiosis I spindle assembly checkpoint; CC: Knl1/Spc105 complex, chromosome, chromosome, centromeric region, cytoplasm, cytosol, dendrite, kinetochore, nuclear body, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O95229
Entrez ID: 11130
|
Does Knockout of PAQR3 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
PAQR3
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: PAQR3 (progestin and adipoQ receptor family member 3)
Type: protein-coding
Summary: This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017].
Gene Ontology: BP: NLS-bearing protein import into nucleus, negative regulation of MAP kinase activity, negative regulation of neuron projection development, negative regulation of peptidyl-serine phosphorylation, negative regulation of peroxisome proliferator activated receptor signaling pathway, negative regulation of protein phosphorylation, peroxisome proliferator activated receptor signaling pathway, positive regulation of SREBP signaling pathway, positive regulation of cholesterol biosynthetic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein localization to Golgi apparatus, protein maturation; MF: protein binding, protein-membrane adaptor activity, ubiquitin-like ligase-substrate adaptor activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of MAPK pathway, RAF/MAP kinase cascade, Signal Transduction
UniProt: Q6TCH7
Entrez ID: 152559
|
Does Knockout of RECK in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
RECK
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: RECK (reversion inducing cysteine rich protein with kazal motifs)
Type: protein-coding
Summary: The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: Wnt signaling pathway, blood vessel maturation, canonical Wnt signaling pathway, embryo implantation, embryonic forelimb morphogenesis, extracellular matrix organization, negative regulation of cell migration, negative regulation of extracellular matrix disassembly, positive regulation of canonical Wnt signaling pathway, regulation of angiogenesis, regulation of canonical Wnt signaling pathway, regulation of establishment of blood-brain barrier, regulation of extracellular matrix organization, sprouting angiogenesis; MF: Wnt-protein binding, coreceptor activity, endopeptidase inhibitor activity, metalloendopeptidase inhibitor activity, peptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity; CC: Wnt signalosome, extracellular region, membrane, plasma membrane, side of membrane
Pathways: Metabolism of proteins, MicroRNAs in cancer - Homo sapiens (human), Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, inhibition of matrix metalloproteinases
UniProt: O95980
Entrez ID: 8434
|
Does Activation of TTC14 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
TTC14
|
protein/peptide accumulation
|
T cell
|
Gene: TTC14 (tetratricopeptide repeat domain 14)
Type: protein-coding
Summary: Predicted to enable nucleic acid binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: Ectoderm Differentiation
UniProt: Q96N46
Entrez ID: 151613
|
Does Knockout of ZNF14 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
ZNF14
|
cell proliferation
|
Cancer Cell Line
|
Gene: ZNF14 (zinc finger protein 14)
Type: protein-coding
Summary: The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription, Validated nuclear estrogen receptor beta network
UniProt: P17017
Entrez ID: 7561
|
Does Knockout of IGBP1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
IGBP1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: IGBP1 (immunoglobulin binding protein 1)
Type: protein-coding
Summary: The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell activation, intracellular signal transduction, negative regulation of stress-activated MAPK cascade, negative regulation of transcription by RNA polymerase II, regulation of dephosphorylation, regulation of microtubule-based movement, regulation of signal transduction, response to interleukin-1, response to tumor necrosis factor, signal transduction; MF: protein binding, protein phosphatase 2A binding, protein phosphatase regulator activity; CC: cytoplasm, cytosol
Pathways: 16p11.2 proximal deletion syndrome, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human)
UniProt: P78318
Entrez ID: 3476
|
Does Knockout of MRPL27 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
MRPL27
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MRPL27 (mitochondrial ribosomal protein L27)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9P0M9
Entrez ID: 51264
|
Does Knockout of ALG12 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
ALG12
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ALG12 (ALG12 alpha-1,6-mannosyltransferase)
Type: protein-coding
Summary: This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein folding, protein glycosylation; MF: alpha-1,6-mannosyltransferase activity, dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity, glycosyltransferase activity, mannosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, lumenal side of endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective ALG12 causes CDG-1g, Disease, Diseases associated with N-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), Post-translational protein modification, Various types of N-glycan biosynthesis - Homo sapiens (human)
UniProt: Q9BV10
Entrez ID: 79087
|
Does Knockout of SLCO4A1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
SLCO4A1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: SLCO4A1 (solute carrier organic anion transporter family member 4A1)
Type: protein-coding
Summary: Predicted to enable sodium-independent organic anion transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: monoatomic ion transport, organic anion transport, prostaglandin transport, sodium-independent organic anion transport, thyroid hormone transport, transmembrane transport; MF: organic anion transmembrane transporter activity, prostaglandin transmembrane transporter activity, protein binding, sodium-independent organic anion transmembrane transporter activity, thyroid hormone transmembrane transporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, membrane, plasma membrane
Pathways: Organic anion transport by SLCO transporters, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: Q96BD0
Entrez ID: 28231
|
Does Knockout of ELP1 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
ELP1
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: ELP1 (elongator acetyltransferase complex subunit 1)
Type: protein-coding
Summary: The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: regulation of translation, tRNA processing, tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation, tRNA wobble uridine modification; MF: protein binding, tRNA binding; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, IL1, TNFalpha
UniProt: O95163
Entrez ID: 8518
|
Does Knockout of RPS28 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
RPS28
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: RPS28 (ribosomal protein S28)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maturation of SSU-rRNA, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, extracellular exosome, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62857
Entrez ID: 6234
|
Does Knockout of ISG20L2 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
ISG20L2
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: ISG20L2 (interferon stimulated exonuclease gene 20 like 2)
Type: protein-coding
Summary: This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: DNA metabolic process, RNA processing, ribosome biogenesis; MF: 3'-5'-RNA exonuclease activity, RNA binding, exonuclease activity, hydrolase activity, nuclease activity, nucleic acid binding, protein binding; CC: nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9H9L3
Entrez ID: 81875
|
Does Knockout of MAGEA12 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
MAGEA12
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MAGEA12 (MAGE family member A12)
Type: protein-coding
Summary: This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014].
Gene Ontology: MF: histone deacetylase binding, protein binding
Pathways:
UniProt: P43365
Entrez ID: 4111
|
Does Knockout of CFC1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
CFC1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: CFC1 (cryptic, EGF-CFC family member 1)
Type: protein-coding
Summary: This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: anterior/posterior pattern specification, blood vessel development, determination of left/right symmetry, gastrulation, heart development, nodal signaling pathway, signal transduction; MF: activin receptor binding, nodal binding; CC: cell surface, extracellular region, membrane, plasma membrane, side of membrane
Pathways: Developmental Biology, Regulation of signaling by NODAL, Signaling by NODAL
UniProt: P0CG37
Entrez ID: 55997
|
Does Knockout of C11orf24 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
C11orf24
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: C11orf24 (chromosome 11 open reading frame 24)
Type: protein-coding
Summary: Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Golgi apparatus, membrane, nucleoplasm, plasma membrane
Pathways:
UniProt: Q96F05
Entrez ID: 53838
|
Does Knockout of RNASEH2A in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
RNASEH2A
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: RNASEH2A (ribonuclease H2 subunit A)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].
Gene Ontology: BP: DNA replication, DNA replication, removal of RNA primer, RNA catabolic process, RNA metabolic process, mismatch repair; MF: RNA binding, RNA nuclease activity, RNA-DNA hybrid ribonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, protein binding; CC: cytosol, nucleoplasm, nucleus, ribonuclease H2 complex
Pathways: DNA replication - Homo sapiens (human)
UniProt: O75792
Entrez ID: 10535
|
Does Knockout of CREBBP in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
CREBBP
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: CREBBP (CREB binding lysine acetyltransferase)
Type: protein-coding
Summary: This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009].
Gene Ontology: BP: N-terminal peptidyl-lysine acetylation, canonical NF-kappaB signal transduction, cellular response to UV, cellular response to nutrient levels, chromatin remodeling, double-strand break repair via homologous recombination, embryonic digit morphogenesis, energy homeostasis, homeostatic process, negative regulation of transcription by RNA polymerase I, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of protein localization to nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, protein K48-linked deubiquitination, protein acetylation, protein destabilization, protein stabilization, protein-containing complex assembly, regulation of DNA-templated transcription, regulation of cellular response to heat, regulation of smoothened signaling pathway, regulation of transcription by RNA polymerase II, response to hypoxia, rhythmic process, signal transduction, stimulatory C-type lectin receptor signaling pathway; MF: DNA-binding transcription factor binding, MRF binding, RNA polymerase II-specific DNA-binding transcription factor binding, acetyltransferase activity, acyltransferase activity, chromatin DNA binding, chromatin binding, damaged DNA binding, histone H3K18 acetyltransferase activity, histone H3K27 acetyltransferase activity, histone acetyltransferase activity, metal ion binding, p53 binding, peptide lactyltransferase (CoA-dependent) activity, protein binding, protein-lysine-acetyltransferase activity, tau protein binding, transcription coactivator activity, transcription coactivator binding, transcription coregulator activity, transcription corepressor activity, transferase activity, zinc ion binding; CC: chromatin, cytoplasm, cytosol, histone acetyltransferase complex, nuclear body, nucleoplasm, nucleus, transcription regulator complex
Pathways: 15q13.3 copy number variation syndrome, Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Activation of gene expression by SREBF (SREBP), Activation of the TFAP2 (AP-2) family of transcription factors, Adaptive Immune System, Adherens junction - Homo sapiens (human), Adipogenesis, Androgen receptor signaling pathway, Angiogenesis, Attenuation phase, BMAL1:CLOCK,NPAS2 activates circadian expression, C-MYB transcription factor network, C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, Cell cycle - Homo sapiens (human), Cellular response to chemical stress, Cellular response to heat stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Ciliary landscape, Circadian clock, Co-inhibition by PD-1, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Cytoprotection by HMOX1, Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, Developmental Biology, Direct p53 effectors, Disease, Diseases of signal transduction by growth factor receptors and second messengers, E2F transcription factor network, ESR-mediated signaling, Ebola Virus Pathway on Host, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Estrogen-dependent gene expression, Evasion by RSV of host interferon responses, Expression of BMAL (ARNTL), CLOCK, and NPAS2, FOXA1 transcription factor network, FOXM1 transcription factor network, FOXO-mediated transcription, FOXO-mediated transcription of cell death genes, Formation of paraxial mesoderm, Formation of the beta-catenin:TCF transactivating complex, FoxO family signaling, FoxO signaling pathway - Homo sapiens (human), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling pathway - Homo sapiens (human), Glucocorticoid receptor regulatory network, Growth hormone synthesis, secretion and action - Homo sapiens (human), HATs acetylate histones, HIF-1 signaling pathway - Homo sapiens (human), HIF-1-alpha transcription factor network, HIF-2-alpha transcription factor network, HSF1-dependent transactivation, Hedgehog signaling events mediated by Gli proteins, Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex, Heme signaling, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), IFN-gamma pathway, IL-6 signaling pathway, IL12 signaling mediated by STAT4, IL4, IL6, Immune System, Infectious disease, Influenza A - Homo sapiens (human), Initiation of transcription and translation elongation at the HIV-1 LTR, Innate Immune System, JAK-STAT signaling pathway - Homo sapiens (human), KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production, Long-term potentiation - Homo sapiens (human), MITF-M-regulated melanocyte development, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Male infertility, Maternal to zygotic transition (MZT), Melanogenesis - Homo sapiens (human), Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, MicroRNAs in cancer - Homo sapiens (human), Mitochondrial biogenesis, NFE2L2 regulates pentose phosphate pathway genes, NFE2L2 regulating ER-stress associated genes, NFE2L2 regulating MDR associated enzymes, NFE2L2 regulating anti-oxidant/detoxification enzymes, NFE2L2 regulating inflammation associated genes, NFE2L2 regulating tumorigenic genes, NOTCH1 Intracellular Domain Regulates Transcription, NOTCH3 Intracellular Domain Regulates Transcription, NOTCH4 Intracellular Domain Regulates Transcription, NPAS4 regulates expression of target genes, Notch Signaling, Notch signaling pathway - Homo sapiens (human), Notch-HLH transcription pathway, Notch-mediated HES/HEY network, Nuclear events mediated by NFE2L2, Organelle biogenesis and maintenance, PPARA activates gene expression, Pathways affected in adenoid cystic carcinoma, Pathways in cancer - Homo sapiens (human), Pathways in clear cell renal cell carcinoma, Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes, Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters, Post-translational protein modification, Posttranslational regulation of adherens junction stability and dissassembly, Pre-NOTCH Expression and Processing, Pre-NOTCH Transcription and Translation, Presenilin action in Notch and Wnt signaling, Prolactin, Prostate cancer - Homo sapiens (human), RNA Polymerase II Transcription, RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression, RSV-host interactions, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells, RUNX3 regulates NOTCH signaling, Regulation of Androgen receptor activity, Regulation of FOXO transcriptional activity by acetylation, Regulation of NFE2L2 gene expression, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Regulation of beta-cell development, Regulation of cholesterol biosynthesis by SREBP (SREBF), Regulation of gene expression by Hypoxia-inducible Factor, Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Regulation of lipid metabolism by PPARalpha, Regulation of nuclear SMAD2/3 signaling, Regulation of retinoblastoma protein, Regulatory circuits of the STAT3 signaling pathway, Renal cell carcinoma - Homo sapiens (human), Respiratory Syncytial Virus Infection Pathway, Retinoic acid receptors-mediated signaling, Role of Calcineurin-dependent NFAT signaling in lymphocytes, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription cofactors, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH3, Signaling by NOTCH4, Signaling by Nuclear Receptors, Signaling by WNT, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class III, Signaling events mediated by Stem cell factor receptor (c-Kit), Signaling events mediated by TCPTP, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, TCF dependent signaling in response to WNT, TCR, TGF-beta Receptor Signaling, TGF-beta Signaling Pathway, TGF-beta receptor signaling in skeletal dysplasias, TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, TNF-alpha signaling pathway, TNFalpha, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, TRAF3-dependent IRF activation pathway, TRAF6 mediated IRF7 activation, The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex, The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, Thyroid hormone signaling pathway - Homo sapiens (human), Transcriptional Regulation by NPAS4, Transcriptional Regulation by TP53, Transcriptional activation of mitochondrial biogenesis, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX3, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Transcriptional regulation of white adipocyte differentiation, Tuberculosis - Homo sapiens (human), Type 2 papillary renal cell carcinoma, VEGFA-VEGFR2 Signaling Pathway, Validated targets of C-MYC transcriptional activation, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, Zygotic genome activation (ZGA), acetylation and deacetylation of rela in nucleus, activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor, cAMP signaling pathway - Homo sapiens (human), carm1 and regulation of the estrogen receptor, il-7 signal transduction, inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors, mechanism of gene regulation by peroxisome proliferators via ppara, multi-step regulation of transcription by pitx2, nfat and hypertrophy of the heart , nfkb activation by nontypeable hemophilus influenzae, p53 pathway, pelp1 modulation of estrogen receptor activity, regulation of transcriptional activity by pml, tgf beta signaling pathway, the information processing pathway at the ifn beta enhancer, transcription regulation by methyltransferase of carm1, wnt signaling pathway
UniProt: Q92793
Entrez ID: 1387
|
Does Knockout of XKR3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
XKR3
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: XKR3 (XK related 3)
Type: protein-coding
Summary: XKRX (MIM 300684) and XKR3 are homologs of the Kell blood group precursor XK (MIM 314850), which is a putative membrane transporter and a component of the XK/Kell complex of the Kell blood group system (Calenda et al., 2006 [PubMed 16431037]).[supplied by OMIM, Mar 2008].
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q5GH77
Entrez ID: 150165
|
Does Knockout of ANKRD17 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
ANKRD17
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: ANKRD17 (ankyrin repeat domain 17)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: defense response to bacterium, immune system process, innate immune response, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of MDA-5 signaling pathway, positive regulation of RIG-I signaling pathway, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell cycle, regulation of DNA replication; MF: RNA binding, chromatin binding, nucleic acid binding, protein binding; CC: chromatin, cytoplasm, membrane, nuclear membrane, nucleoplasm, nucleus
Pathways:
UniProt: O75179
Entrez ID: 26057
|
Does Knockout of ZNF433 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
ZNF433
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ZNF433 (zinc finger protein 433)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q8N7K0
Entrez ID: 163059
|
Does Knockout of USP5 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
USP5
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: USP5 (ubiquitin specific peptidase 5)
Type: protein-coding
Summary: Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010].
Gene Ontology: BP: negative regulation of T cell activation, negative regulation of T cell mediated immune response to tumor cell, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of proteasomal protein catabolic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of translation, protein K48-linked deubiquitination, protein deubiquitination, protein ubiquitination, proteolysis, regulation of mitotic cell cycle, regulation of protein stability, regulation protein catabolic process at presynapse; MF: cysteine-type deubiquitinase activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, metal ion binding, peptidase activity, protein binding, ubiquitin binding, zinc ion binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, lysosome, nucleus, presynapse
Pathways: IL-18 signaling pathway
UniProt: P45974
Entrez ID: 8078
|
Does Knockout of NOA1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
NOA1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: NOA1 (nitric oxide associated 1)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: apoptotic process, mitochondrial ribosome assembly, mitochondrion organization; MF: GTP binding, RNA binding, nucleotide binding, protein binding; CC: matrix side of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q8NC60
Entrez ID: 84273
|
Does Knockout of SATB2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
SATB2
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: SATB2 (SATB homeobox 2)
Type: protein-coding
Summary: This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010].
Gene Ontology: BP: cartilage development, chromatin organization, chromatin remodeling, embryonic pattern specification, embryonic skeletal system morphogenesis, negative regulation of transcription by RNA polymerase II, neuron migration, osteoblast development, positive regulation of transcription by RNA polymerase II, regulation of gene expression, regulation of transcription by RNA polymerase II, roof of mouth development; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, histone deacetylase binding, protein binding, sequence-specific DNA binding; CC: chromatin, histone deacetylase complex, nuclear lumen, nuclear matrix, nucleoplasm, nucleus, transcription regulator complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II Transcription, RUNX2 regulates bone development, RUNX2 regulates osteoblast differentiation, Rett syndrome causing genes, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of chromatin organization proteins, Transcription co-factors SKI and SKIL protein partners, Transcriptional regulation by RUNX2
UniProt: Q9UPW6
Entrez ID: 23314
|
Does Knockout of RPLP0 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
RPLP0
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RPLP0 (ribosomal protein lateral stalk subunit P0)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, ribosome biogenesis, translation; MF: RNA binding, large ribosomal subunit rRNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, extracellular exosome, focal adhesion, membrane, nucleus, postsynapse, postsynaptic density, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytokine Signaling in Immune system, Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, EGFR1, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Interleukin-12 family signaling, Interleukin-12 signaling, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by Interleukins, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P05388
Entrez ID: 6175
|
Does Knockout of ZNF587 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
ZNF587
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: ZNF587 (zinc finger protein 587)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q96SQ5
Entrez ID: 84914
|
Does Knockout of CUTC in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
CUTC
|
response to virus
|
Lung Cancer Cell Line
|
Gene: CUTC (cutC copper transporter)
Type: protein-coding
Summary: Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: copper ion homeostasis, copper ion transport, protein tetramerization; MF: copper ion binding, metal ion binding, protein binding; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: Q9NTM9
Entrez ID: 51076
|
Does Knockout of LYPD1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
LYPD1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: LYPD1 (LY6/PLAUR domain containing 1)
Type: protein-coding
Summary: Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Predicted to be involved in acetylcholine receptor signaling pathway. Predicted to act upstream of or within several processes, including behavioral fear response; cholinergic synaptic transmission; and negative regulation of protein localization to plasma membrane. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: acetylcholine receptor signaling pathway, behavioral fear response, negative regulation of protein localization to plasma membrane, protein localization to plasma membrane, response to nicotine, synaptic transmission, cholinergic; MF: acetylcholine receptor binding, acetylcholine receptor inhibitor activity, protein binding; CC: extracellular region, membrane, plasma membrane, side of membrane, synapse
Pathways: Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q8N2G4
Entrez ID: 116372
|
Does Knockout of THAP9 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
THAP9
|
response to chemicals
|
Melanoma Cell Line
|
Gene: THAP9 (THAP domain containing 9)
Type: protein-coding
Summary: Enables sequence-specific DNA binding activity and transposase activity. Involved in DNA integration and transposition, DNA-mediated. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA integration, DNA recombination, DNA transposition; MF: DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, transferase activity, transposase activity, zinc ion binding
Pathways:
UniProt: Q9H5L6
Entrez ID: 79725
|
Does Knockout of ANXA1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
ANXA1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: ANXA1 (annexin A1)
Type: protein-coding
Summary: This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, actin cytoskeleton organization, adaptive immune response, alpha-beta T cell differentiation, arachidonate secretion, cell surface receptor signaling pathway, cell-cell adhesion, cellular response to glucocorticoid stimulus, cellular response to vascular endothelial growth factor stimulus, granulocyte chemotaxis, immune system process, inflammatory response, innate immune response, keratinocyte differentiation, monocyte chemotaxis, myoblast migration involved in skeletal muscle regeneration, negative regulation of T-helper 2 cell differentiation, negative regulation of apoptotic process, negative regulation of exocytosis, negative regulation of interleukin-8 production, negative regulation of transport, neutrophil activation, neutrophil clearance, neutrophil homeostasis, peptide cross-linking, phagocytosis, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of T cell proliferation, positive regulation of T-helper 1 cell differentiation, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of interleukin-2 production, positive regulation of multicellular organismal process, positive regulation of neutrophil apoptotic process, positive regulation of vesicle fusion, positive regulation of wound healing, regulation of cell population proliferation, regulation of cell shape, regulation of hormone secretion, regulation of inflammatory response, regulation of interleukin-1 production, regulation of leukocyte migration, signal transduction; MF: cadherin binding involved in cell-cell adhesion, calcium ion binding, calcium-dependent phospholipid binding, calcium-dependent protein binding, lipid binding, metal ion binding, phosphatidylserine binding, phospholipase A2 inhibitor activity, phospholipase inhibitor activity, phospholipid binding, protein binding, signaling receptor binding; CC: actin filament, adherens junction, apical plasma membrane, basolateral plasma membrane, cell projection, cell surface, cilium, cornified envelope, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, early endosome, early endosome membrane, endosome, endosome membrane, extracellular exosome, extracellular matrix, extracellular region, extracellular space, focal adhesion, lateral plasma membrane, membrane, motile cilium, nucleoplasm, nucleus, phagocytic cup, plasma membrane, sarcolemma, vesicle, vesicle membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Cytokine Signaling in Immune system, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Pancreatic Ductal Cells, EGFR1, Formyl peptide receptors bind formyl peptides and many other ligands, G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Immune System, Integrated breast cancer pathway, Interleukin-4 and Interleukin-13 signaling, Muscle contraction, Peptide ligand-binding receptors, Prostaglandin Synthesis and Regulation, Signal Transduction, Signaling by GPCR, Signaling by Interleukins, Smooth Muscle Contraction, Spinal Cord Injury, VEGFA-VEGFR2 Signaling Pathway, corticosteroids and cardioprotection
UniProt: P04083
Entrez ID: 301
|
Does Knockout of FHOD3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
FHOD3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: FHOD3 (formin homology 2 domain containing 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: actin filament organization, cardiac myofibril assembly, positive regulation of stress fiber assembly, sarcomere organization; MF: actin binding, actin filament binding, protein binding; CC: Z disc, cytoplasm, cytoskeleton
Pathways:
UniProt: Q2V2M9
Entrez ID: 80206
|
Does Knockout of CLCN5 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
CLCN5
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CLCN5 (chloride voltage-gated channel 5)
Type: protein-coding
Summary: This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: chloride transmembrane transport, chloride transport, endocytosis, monoatomic ion transmembrane transport, monoatomic ion transport, renal system process, transmembrane transport; MF: ATP binding, antiporter activity, chloride channel activity, chloride transmembrane transporter activity, identical protein binding, nucleotide binding, protein binding, voltage-gated chloride channel activity; CC: Golgi apparatus, Golgi membrane, apical part of cell, cytosol, early endosome, endosome, endosome membrane, lysosomal membrane, membrane, plasma membrane, synaptic vesicle
Pathways: Ion channel transport, Neutrophil extracellular trap formation - Homo sapiens (human), Stimuli-sensing channels, Transport of small molecules
UniProt: P51795
Entrez ID: 1184
|
Does Inhibition of EIF3H in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
EIF3H
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: EIF3H (eukaryotic translation initiation factor 3 subunit H)
Type: protein-coding
Summary: Enables deubiquitinase activity. Contributes to translation initiation factor activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Located in extracellular exosome and membrane. Part of eukaryotic translation initiation factor 3 complex. Implicated in breast cancer; prostate cancer; and prostate carcinoma. Biomarker of prostate cancer. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of translational initiation, translation, translational initiation; MF: RNA binding, metal-dependent deubiquitinase activity, metallopeptidase activity, peptidase activity, protein binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, extracellular exosome, membrane
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Measles - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, VEGFA-VEGFR2 Signaling Pathway, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: O15372
Entrez ID: 8667
|
Does Knockout of PPIL4 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
PPIL4
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: PPIL4 (peptidylprolyl isomerase like 4)
Type: protein-coding
Summary: This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: RNA binding, isomerase activity, nucleic acid binding, peptidyl-prolyl cis-trans isomerase activity, protein binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8WUA2
Entrez ID: 85313
|
Does Knockout of NBAS in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
NBAS
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NBAS (NBAS subunit of NRZ tethering complex)
Type: protein-coding
Summary: This gene encodes a protein with two leucine zipper domains, a ribosomal protein S14 signature domain and a Sec39 like domain. The protein is thought to be involved in Golgi-to-ER transport. Mutations in this gene are associated with short stature, optic nerve atrophy, and Pelger-Huet anomaly. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; MF: SNARE binding, protein binding; CC: Dsl1/NZR complex, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Vesicle-mediated transport
UniProt: A2RRP1
Entrez ID: 51594
|
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