prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of TRAPPC3 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | TRAPPC3 | cell proliferation | Neuroblastoma Cell Line | Gene: TRAPPC3 (trafficking protein particle complex subunit 3)
Type: protein-coding
Summary: This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the end... |
Does Knockout of CCDC59 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | CCDC59 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: CCDC59 (coiled-coil domain containing 59)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protein binding; CC: nucleoplasm, nucleus
Pathways: M... |
Does Knockout of OR10J5 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | OR10J5 | response to virus | Huh-7 Cell | Gene: OR10J5 (olfactory receptor family 10 subfamily J member 5)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of SCRT1 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | SCRT1 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: SCRT1 (scratch family transcriptional repressor 1)
Type: protein-coding
Summary: This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provide... |
Does Knockout of ABCB8 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | ABCB8 | cell proliferation | Glioblastoma Cell Line | Gene: ABCB8 (ATP binding cassette subfamily B member 8)
Type: protein-coding
Summary: This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic mo... |
Does Knockout of DDX20 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | DDX20 | cell proliferation | T-lymphoma cell line | Gene: DDX20 (DEAD-box helicase 20)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiatio... |
Does Knockout of LRRC36 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | LRRC36 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: LRRC36 (leucine rich repeat containing 36)
Type: protein-coding
Summary: leucine rich repeat containing 36
Gene Ontology:
Pathways:
UniProt: Q1X8D7
Entrez ID: 55282 |
Does Knockout of ATP6V1C1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | ATP6V1C1 | cell proliferation | Ovarian Cancer Cell Line | Gene: ATP6V1C1 (ATPase H+ transporting V1 subunit C1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such int... |
Does Knockout of CDH15 in Cancer Cell Line causally result in cell proliferation? | 0 | 193 | Knockout | CDH15 | cell proliferation | Cancer Cell Line | Gene: CDH15 (cadherin 15)
Type: protein-coding
Summary: This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytopla... |
Does Knockout of CDC16 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | CDC16 | cell proliferation | Astrocytoma Cell Line | Gene: CDC16 (cell division cycle 16)
Type: protein-coding
Summary: The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins f... |
Does Knockout of RARRES2 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | RARRES2 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: RARRES2 (retinoic acid receptor responder 2)
Type: protein-coding
Summary: This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and... |
Does Knockout of CEP55 in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | CEP55 | cell proliferation | Prostate Cancer Cell Line | Gene: CEP55 (centrosomal protein 55)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Acts upstream of or within mitotic cytokinesis. Located in Flemming body; centrio... |
Does Knockout of B4GALT4 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | B4GALT4 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: B4GALT4 (beta-1,4-galactosyltransferase 4)
Type: protein-coding
Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galact... |
Does Knockout of CASP7 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | CASP7 | cell proliferation | Glioblastoma Cell Line | Gene: CASP7 (caspase 7)
Type: protein-coding
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic proce... |
Does Knockout of GSTT2B in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | GSTT2B | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: GSTT2B (glutathione S-transferase theta 2B)
Type: protein-coding
Summary: The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic... |
Does Knockout of KRTAP12-1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | KRTAP12-1 | cell proliferation | Melanoma Cell Line | Gene: KRTAP12-1 (keratin associated protein 12-1)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
... |
Does Knockout of GTF2E1 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | GTF2E1 | cell proliferation | Glioblastoma Cell Line | Gene: GTF2E1 (general transcription factor IIE subunit 1)
Type: protein-coding
Summary: Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of transcription factor TFIID complex and transcrip... |
Does Knockout of TRIM2 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | TRIM2 | cell proliferation | Breast Cancer Cell Line | Gene: TRIM2 (tripartite motif containing 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to ... |
Does Knockout of TICRR in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | TICRR | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: TICRR (TOPBP1 interacting checkpoint and replication regulator)
Type: protein-coding
Summary: Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication,... |
Does Knockout of EFNA1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | EFNA1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: EFNA1 (ephrin A1)
Type: protein-coding
Summary: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous sys... |
Does Knockout of SLC7A6OS in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | SLC7A6OS | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SLC7A6OS (solute carrier family 7 member 6 opposite strand)
Type: protein-coding
Summary: Predicted to be involved in developmental process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm and nucleus. Implicated in progres... |
Does Knockout of KRTAP10-2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | KRTAP10-2 | cell proliferation | Colonic Cancer Cell Line | Gene: KRTAP10-2 (keratin associated protein 10-2)
Type: protein-coding
Summary: This gene encodes a member of the high sulfur-type keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. This gene is loca... |
Does Knockout of MAP1LC3C in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | MAP1LC3C | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: MAP1LC3C (microtubule associated protein 1 light chain 3 gamma)
Type: protein-coding
Summary: Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2... |
Does Knockout of COL27A1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | COL27A1 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: COL27A1 (collagen type XXVII alpha 1 chain)
Type: protein-coding
Summary: This gene encodes a member of the fibrillar collagen family, and plays a role during the calcification of cartilage and the transition of cartilage to bone. The encoded protein product is a preproprotein. It includes an N-te... |
Does Knockout of FAM163A in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | FAM163A | cell proliferation | T-lymphoma cell line | Gene: FAM163A (family with sequence similarity 163 member A)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q96GL9
Entrez ID: 148753 |
Does Knockout of PSMD12 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | PSMD12 | cell proliferation | Melanoma Cell Line | Gene: PSMD12 (proteasome 26S subunit, non-ATPase 12)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings ... |
Does Knockout of CENPL in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | CENPL | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: CENPL (centromere protein L)
Type: protein-coding
Summary: CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMe... |
Does Knockout of CHCHD10 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | CHCHD10 | cell proliferation | Endometrial Cancer Cell Line | Gene: CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein that is enriched at cristae junctions in the intermembrane space. It may play a role in cristae morphology maintenance or oxidative phosphorylation. Mutations ... |
Does Knockout of BCAS3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | BCAS3 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: BCAS3 (BCAS3 microtubule associated cell migration factor)
Type: protein-coding
Summary: Enables several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and histone acetyltransferase binding activity. Involved in cellular response to estrogen stimulus; pos... |
Does Knockout of MBNL1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | MBNL1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: MBNL1 (muscleblind like splicing regulator 1)
Type: protein-coding
Summary: This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs.... |
Does Knockout of TMEM18 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | TMEM18 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: TMEM18 (transmembrane protein 18)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Involved in cell migration. Located in nuclear membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell migration, eating behavior, energy homeostasis; M... |
Does Knockout of CCDC137 in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | CCDC137 | response to virus | Hepatoma Cell Line | Gene: CCDC137 (coiled-coil domain containing 137)
Type: protein-coding
Summary: Enables RNA binding activity. Located in chromosome and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protein binding; CC: chromosome, nucleolus, nucleoplasm,... |
Does Knockout of RPS13 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | RPS13 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: RPS13 (ribosomal protein S13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of PIANP in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | PIANP | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: PIANP (PILR alpha associated neural protein)
Type: protein-coding
Summary: This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins. [provid... |
Does Knockout of CDYL in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | CDYL | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: CDYL (chromodomain Y like)
Type: protein-coding
Summary: Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked ge... |
Does Knockout of WASHC2A in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | WASHC2A | cell proliferation | Breast Cancer Cell Line | Gene: WASHC2A (WASH complex subunit 2A)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol phosphate binding activity and retromer complex binding activity. Involved in protein localization to endosome. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Apr ... |
Does Knockout of HSPD1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | HSPD1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: HSPD1 (heat shock protein family D (Hsp60) member 1)
Type: protein-coding
Summary: This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newl... |
Does Knockout of ATP6V1G1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | ATP6V1G1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: ATP6V1G1 (ATPase H+ transporting V1 subunit G1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intr... |
Does Knockout of DEFA5 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | DEFA5 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: DEFA5 (defensin alpha 5)
Type: protein-coding
Summary: Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respira... |
Does Knockout of ELOB in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | ELOB | cell proliferation | Multiple Myeloma Cell Line | Gene: ELOB (elongin B)
Type: protein-coding
Summary: This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the poly... |
Does Knockout of CCDC86 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | CCDC86 | cell proliferation | Renal Cancer Cell Line | Gene: CCDC86 (coiled-coil domain containing 86)
Type: protein-coding
Summary: Enables RNA binding activity. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromosome segregation, mitotic nuclear division; MF: RNA bindin... |
Does Knockout of PSMC3 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | PSMC3 | response to virus | Lung Cancer Cell Line | Gene: PSMC3 (proteasome 26S subunit, ATPase 3)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are co... |
Does Knockout of GAR1 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | GAR1 | cell proliferation | Cancer Cell Line | Gene: GAR1 (GAR1 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA ... |
Does Knockout of SEC13 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | SEC13 | cell proliferation | Cancer Cell Line | Gene: SEC13 (SEC13 homolog, nuclear pore and COPII component)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, whi... |
Does Knockout of SLC27A6 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | SLC27A6 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: SLC27A6 (solute carrier family 27 member 6)
Type: protein-coding
Summary: This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding... |
Does Activation of NHLRC2 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | NHLRC2 | protein/peptide accumulation | T cell | Gene: NHLRC2 (NHL repeat containing 2)
Type: protein-coding
Summary: Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, cytosol, extracellular region, platelet alpha granule lumen
Pathways:
UniProt: Q8NBF2
Entrez ID:... |
Does Knockout of CUL5 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | CUL5 | cell proliferation | Gastric Cancer Cell Line | Gene: CUL5 (cullin 5)
Type: protein-coding
Summary: Enables ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within cerebral cortex radially oriented ... |
Does Knockout of SEPSECS in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | SEPSECS | cell proliferation | Melanoma Cell Line | Gene: SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)
Type: protein-coding
Summary: The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein en... |
Does Knockout of TDRD12 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | TDRD12 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: TDRD12 (tudor domain containing 12)
Type: protein-coding
Summary: Predicted to enable ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be involved in several processes, including gamete generation; gene silencing by RNA; and piRNA metabolic process. Pred... |
Does Knockout of AMOTL1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | AMOTL1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: AMOTL1 (angiomotin like 1)
Type: protein-coding
Summary: The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is... |
Does Knockout of TAF1C in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | TAF1C | cell proliferation | Bladder Carcinoma | Gene: TAF1C (TATA-box binding protein associated factor, RNA polymerase I subunit C)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polym... |
Does Knockout of BRIX1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | BRIX1 | cell proliferation | Ovarian Cancer Cell Line | Gene: BRIX1 (biogenesis of ribosomes BRX1)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in ribosomal large subunit assembly. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: rRNA processing, ribo... |
Does Knockout of MAP2K4 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | MAP2K4 | cell proliferation | Monocytic Leukemia Cell Line | Gene: MAP2K4 (mitogen-activated protein kinase kinase 4)
Type: protein-coding
Summary: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular proc... |
Does Knockout of CCAR2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | CCAR2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: CCAR2 (cell cycle and apoptosis regulator 2)
Type: protein-coding
Summary: Enables RNA polymerase II complex binding activity and enzyme inhibitor activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of signal transduction; and regulation ... |
Does Activation of MICA in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | MICA | protein/peptide accumulation | T cell | Gene: MICA (MHC class I polypeptide-related sequence A)
Type: protein-coding
Summary: This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not s... |
Does Knockout of NOP16 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | NOP16 | cell proliferation | Prostate Cancer Cell Line | Gene: NOP16 (NOP16 nucleolar protein)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcri... |
Does Knockout of NUP43 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | NUP43 | cell proliferation | Neuroblastoma Cell Line | Gene: NUP43 (nucleoporin 43)
Type: protein-coding
Summary: Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (L... |
Does Knockout of FOXI2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | FOXI2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: FOXI2 (forkhead box I2)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell d... |
Does Knockout of HPCAL4 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | HPCAL4 | cell proliferation | Medulloblastoma Cell Line | Gene: HPCAL4 (hippocalcin like 4)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involv... |
Does Knockout of RPL41 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | RPL41 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: RPL41 (ribosomal protein L41)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of PAGE1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | PAGE1 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PAGE1 (PAGE family member 1)
Type: protein-coding
Summary: This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. Unlike the other gene family members, this gene does not encode an antigenic peptide. Nothing is presently k... |
Does Knockout of MRPL27 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | MRPL27 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: MRPL27 (mitochondrial ribosomal protein L27)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of PLA2G10 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | PLA2G10 | cell proliferation | Bladder Carcinoma | Gene: PLA2G10 (phospholipase A2 group X)
Type: protein-coding
Summary: This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the matu... |
Does Knockout of NUP214 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | NUP214 | cell proliferation | Breast Cancer Cell Line | Gene: NUP214 (nucleoporin 214)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear po... |
Does Knockout of ATG16L1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | ATG16L1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ATG16L1 (autophagy related 16 like 1)
Type: protein-coding
Summary: The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause o... |
Does Knockout of MUC21 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | MUC21 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: MUC21 (mucin 21, cell surface associated)
Type: protein-coding
Summary: This gene encodes a large membrane-bound glycoprotein which is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These pr... |
Does Knockout of RPL18 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | RPL18 | cell proliferation | Medulloblastoma Cell Line | Gene: RPL18 (ribosomal protein L18)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of PRELID3B in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | PRELID3B | cell proliferation | Gastric Cancer Cell Line | Gene: PRELID3B (PRELI domain containing 3B)
Type: protein-coding
Summary: Predicted to enable phosphatidic acid transfer activity. Predicted to be involved in phospholipid transport. Predicted to be active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of KCNJ4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | KCNJ4 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: KCNJ4 (potassium inwardly rectifying channel subfamily J member 4)
Type: protein-coding
Summary: Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are ref... |
Does Knockout of PAN2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | PAN2 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: PAN2 (poly(A) specific ribonuclease subunit PAN2)
Type: protein-coding
Summary: This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease tha... |
Does Knockout of RFC3 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | RFC3 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: RFC3 (replication factor C subunit 3)
Type: protein-coding
Summary: The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a ... |
Does Knockout of DBNDD2 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | DBNDD2 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: DBNDD2 (dysbindin domain containing 2)
Type: protein-coding
Summary: Involved in negative regulation of protein kinase activity. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERK1 and ERK2 cascade, apoptotic process, monoatom... |
Does Knockout of NOL10 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | NOL10 | response to chemicals | Colorectal Cancer Cell Line | Gene: NOL10 (nucleolar protein 10)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene On... |
Does Knockout of ARHGAP30 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | ARHGAP30 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ARHGAP30 (Rho GTPase activating protein 30)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase mediated signal transduction. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of POLR2E in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | POLR2E | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: POLR2E (RNA polymerase II, I and III subunit E)
Type: protein-coding
Summary: This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is prese... |
Does Knockout of SESN1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | SESN1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: SESN1 (sestrin 1)
Type: protein-coding
Summary: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by acti... |
Does Knockout of AAGAB in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | AAGAB | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: AAGAB (alpha and gamma adaptin binding protein)
Type: protein-coding
Summary: The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmop... |
Does Knockout of CCDC169 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | CCDC169 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: CCDC169 (coiled-coil domain containing 169)
Type: protein-coding
Summary: coiled-coil domain containing 169
Gene Ontology:
Pathways:
UniProt: A6NNP5
Entrez ID: 728591 |
Does Knockout of COG4 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | COG4 | response to chemicals | Monocytic Leukemia Cell Line | Gene: COG4 (component of oligomeric golgi complex 4)
Type: protein-coding
Summary: The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation t... |
Does Knockout of PPCDC in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | PPCDC | response to chemicals | Monocytic Leukemia Cell Line | Gene: PPCDC (phosphopantothenoylcysteine decarboxylase)
Type: protein-coding
Summary: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantoth... |
Does Knockout of SMC3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | SMC3 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: SMC3 (structural maintenance of chromosomes 3)
Type: protein-coding
Summary: This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenanc... |
Does Knockout of RPS15 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | RPS15 | cell proliferation | Breast Cancer Cell Line | Gene: RPS15 (ribosomal protein S15)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of ZMYND8 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | ZMYND8 | cell proliferation | Renal Cancer Cell Line | Gene: ZMYND8 (zinc finger MYND-type containing 8)
Type: protein-coding
Summary: The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell ... |
Does Activation of OSTM1 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | OSTM1 | response to virus | Hepatoma Cell Line | Gene: OSTM1 (osteoclastogenesis associated transmembrane protein 1)
Type: protein-coding
Summary: This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the ... |
Does Knockout of IRX4 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | IRX4 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: IRX4 (iroquois homeobox 4)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; neuron differentiatio... |
Does Knockout of ZFP69B in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | ZFP69B | cell proliferation | Renal Cancer Cell Line | Gene: ZFP69B (ZFP69 zinc finger protein B)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Golgi organization. Located in n... |
Does Knockout of PLEKHF2 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | PLEKHF2 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: PLEKHF2 (pleckstrin homology and FYVE domain containing 2)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in protein transport. Located in transport vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontolo... |
Does Knockout of KIF21A in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | KIF21A | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: KIF21A (kinesin family member 21A)
Type: protein-coding
Summary: This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be ... |
Does Knockout of ITGB5 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | ITGB5 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ITGB5 (integrin subunit beta 5)
Type: protein-coding
Summary: This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surf... |
Does Knockout of POTEG in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | POTEG | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: POTEG (POTE ankyrin domain family member G)
Type: protein-coding
Summary: POTE ankyrin domain family member G
Gene Ontology:
Pathways:
UniProt: Q6S5H5
Entrez ID: 404785 |
Does Knockout of TTYH1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | TTYH1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: TTYH1 (tweety family member 1)
Type: protein-coding
Summary: This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. ... |
Does Knockout of NRM in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | NRM | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: NRM (nurim)
Type: protein-coding
Summary: The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternativ... |
Does Knockout of POLR2A in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | POLR2A | cell proliferation | Endometrial Cancer Cell Line | Gene: POLR2A (RNA polymerase II subunit A)
Type: protein-coding
Summary: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that ... |
Does Activation of ARHGAP11B in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | ARHGAP11B | protein/peptide accumulation | T cell | Gene: ARHGAP11B (Rho GTPase activating protein 11B)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process.... |
Does Knockout of SPRTN in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | SPRTN | cell proliferation | Bladder Carcinoma | Gene: SPRTN (SprT-like N-terminal domain)
Type: protein-coding
Summary: The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional D... |
Does Knockout of IKZF5 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | IKZF5 | cell proliferation | Breast Cancer Cell Line | Gene: IKZF5 (IKAROS family zinc finger 5)
Type: protein-coding
Summary: Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002].
Gene ... |
Does Knockout of UBE2I in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | UBE2I | cell proliferation | Prostate Cancer Cell Line | Gene: UBE2I (ubiquitin conjugating enzyme E2 I)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enz... |
Does Knockout of NAF1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | NAF1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: NAF1 (nuclear assembly factor 1 ribonucleoprotein)
Type: protein-coding
Summary: Enables identical protein binding activity and telomerase RNA binding activity. Involved in regulation of nucleobase-containing compound metabolic process; ribosome biogenesis; and telomerase holoenzyme complex assemb... |
Does Knockout of ZSWIM7 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | ZSWIM7 | cell proliferation | Bladder Carcinoma | Gene: ZSWIM7 (zinc finger SWIM-type containing 7)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Involved in double-strand break repair via homologous recombination and protein stabilization. Part of Shu complex. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of UTP15 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | UTP15 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: UTP15 (UTP15 small subunit processome component)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in endoplasmic reticulum and fibrillar center. [provided by Alliance... |
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