prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of TRAPPC3 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
TRAPPC3
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: TRAPPC3 (trafficking protein particle complex subunit 3)
Type: protein-coding
Summary: This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: COPII vesicle coating, Golgi vesicle transport, endoplasmic reticulum to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, vesicle coating, vesicle tethering, vesicle-mediated transport; CC: Golgi apparatus, Golgi membrane, TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, cis-Golgi network membrane, cytoplasm, cytosol, endoplasmic reticulum
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O43617
Entrez ID: 27095
|
Does Knockout of CCDC59 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
CCDC59
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CCDC59 (coiled-coil domain containing 59)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protein binding; CC: nucleoplasm, nucleus
Pathways: Metabolism of proteins, Surfactant metabolism
UniProt: Q9P031
Entrez ID: 29080
|
Does Knockout of OR10J5 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
OR10J5
|
response to virus
|
Huh-7 Cell
|
Gene: OR10J5 (olfactory receptor family 10 subfamily J member 5)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, angiogenesis, chemotaxis, detection of chemical stimulus involved in sensory perception of smell, lipid homeostasis, muscle organ development, regulation of angiogenesis, regulation of muscle cell differentiation, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NHC4
Entrez ID: 127385
|
Does Knockout of SCRT1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
SCRT1
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: SCRT1 (scratch family transcriptional repressor 1)
Type: protein-coding
Summary: This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of neuron migration, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nuclear body, nucleus
Pathways:
UniProt: Q9BWW7
Entrez ID: 83482
|
Does Knockout of ABCB8 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
ABCB8
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ABCB8 (ATP binding cassette subfamily B member 8)
Type: protein-coding
Summary: This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: cell volume homeostasis, mitochondrial potassium ion transmembrane transport, mitochondrial transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, transmembrane transport; MF: ABC-type transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled transmembrane transporter activity, nucleotide binding, protein binding; CC: ATP-binding cassette (ABC) transporter complex, membrane, mitochondrial ATP-gated potassium channel complex, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleolus, nucleoplasm
Pathways: ABC transporters - Homo sapiens (human), ABC-family proteins mediated transport, Mitochondrial ABC transporters, Transport of small molecules
UniProt: Q9NUT2
Entrez ID: 11194
|
Does Knockout of DDX20 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
DDX20
|
cell proliferation
|
T-lymphoma cell line
|
Gene: DDX20 (DEAD-box helicase 20)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of transcription by RNA polymerase II, oogenesis, positive regulation of apoptotic process, regulation of steroid biosynthetic process, spliceosomal snRNP assembly, spliceosomal tri-snRNP complex assembly; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA-binding transcription factor binding, RNA helicase activity, helicase activity, histone deacetylase binding, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding, protein domain specific binding, protein-macromolecule adaptor activity, ribonucleoside triphosphate phosphatase activity; CC: Gemini of Cajal bodies, RNA polymerase II transcription repressor complex, SMN complex, SMN-Sm protein complex, cytoplasm, cytoskeleton, cytosol, membrane, nuclear body, nucleoplasm, nucleus, protein-containing complex, transcription repressor complex
Pathways: Disease, Infectious disease, Male infertility, Metabolism of RNA, Metabolism of non-coding RNA, RNA transport - Homo sapiens (human), SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, Viral Infection Pathways, mRNA Processing, mets affect on macrophage differentiation, snRNP Assembly
UniProt: Q9UHI6
Entrez ID: 11218
|
Does Knockout of LRRC36 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
LRRC36
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: LRRC36 (leucine rich repeat containing 36)
Type: protein-coding
Summary: leucine rich repeat containing 36
Gene Ontology:
Pathways:
UniProt: Q1X8D7
Entrez ID: 55282
|
Does Knockout of ATP6V1C1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
ATP6V1C1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: ATP6V1C1 (ATPase H+ transporting V1 subunit C1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification; MF: protein binding, proton transmembrane transporter activity, proton-transporting ATPase activity, rotational mechanism; CC: ATPase complex, apical part of cell, clathrin-coated vesicle membrane, cytoplasmic vesicle, cytosol, extracellular exosome, extrinsic component of synaptic vesicle membrane, lysosomal membrane, membrane, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, proton-transporting two-sector ATPase complex, synapse, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, mTOR signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: P21283
Entrez ID: 528
|
Does Knockout of CDH15 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
CDH15
|
cell proliferation
|
Cancer Cell Line
|
Gene: CDH15 (cadherin 15)
Type: protein-coding
Summary: This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adherens junction organization, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell migration, cell morphogenesis, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-cell junction assembly, homophilic cell adhesion via plasma membrane adhesion molecules; MF: beta-catenin binding, cadherin binding, calcium ion binding, metal ion binding, protein binding; CC: Golgi apparatus, adherens junction, catenin complex, caveola, extracellular exosome, membrane, neuromuscular junction, plasma membrane
Pathways: 22q11.2 copy number variation syndrome, Adherens junctions interactions, Cell adhesion molecules - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Developmental Biology, Hippo-Merlin Signaling Dysregulation, Myogenesis, Pathways Regulating Hippo Signaling
UniProt: P55291
Entrez ID: 1013
|
Does Knockout of CDC16 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
CDC16
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: CDC16 (cell division cycle 16)
Type: protein-coding
Summary: The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, positive regulation of mitotic metaphase/anaphase transition, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; CC: anaphase-promoting complex, centrosome, cytoplasm, cytoskeleton, cytosol, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q13042
Entrez ID: 8881
|
Does Knockout of RARRES2 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
RARRES2
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: RARRES2 (retinoic acid receptor responder 2)
Type: protein-coding
Summary: This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: antifungal humoral response, antifungal innate immune response, cell differentiation, cellular response to insulin stimulus, chemotaxis, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, developmental process, embryonic digestive tract development, inflammatory response, innate immune response, insulin receptor signaling pathway, positive regulation of chemotaxis, positive regulation of fat cell differentiation, positive regulation of macrophage chemotaxis, positive regulation of protein phosphorylation, positive regulation of systemic arterial blood pressure, regulation of lipid catabolic process, response to activity, response to caloric restriction, response to nutrient levels, retinoid metabolic process; MF: protein binding, signaling receptor binding; CC: extracellular matrix, extracellular region, extracellular space, platelet dense granule lumen
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q99969
Entrez ID: 5919
|
Does Knockout of CEP55 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
CEP55
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: CEP55 (centrosomal protein 55)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Acts upstream of or within mitotic cytokinesis. Located in Flemming body; centriolar satellite; and plasma membrane. Implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, cranial skeletal system development, establishment of protein localization, midbody abscission, mitotic cytokinesis, mitotic metaphase chromosome alignment, nucleus organization, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: identical protein binding, protein binding; CC: Flemming body, centriole, centrosome, cleavage furrow, cytoplasm, cytoskeleton, intercellular bridge, membrane, midbody
Pathways:
UniProt: Q53EZ4
Entrez ID: 55165
|
Does Knockout of B4GALT4 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
B4GALT4
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: B4GALT4 (beta-1,4-galactosyltransferase 4)
Type: protein-coding
Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate metabolic process, glycosylation, keratan sulfate proteoglycan biosynthetic process, lactosylceramide biosynthetic process, lipid metabolic process, membrane lipid metabolic process, protein glycosylation; MF: N-acetyllactosamine synthase activity, UDP-galactosyltransferase activity, galactosyltransferase activity, glycosyltransferase activity, metal ion binding, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, extracellular region, membrane
Pathways: Asparagine N-linked glycosylation, Glycosaminoglycan biosynthesis - keratan sulfate - Homo sapiens (human), Glycosaminoglycan metabolism, Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human), Keratan sulfate biosynthesis, Keratan sulfate/keratin metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, N-Glycan antennae elongation, N-glycan antennae elongation in the medial/trans-Golgi, Post-translational protein modification, Transport to the Golgi and subsequent modification
UniProt: O60513
Entrez ID: 8702
|
Does Knockout of CASP7 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
CASP7
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CASP7 (caspase 7)
Type: protein-coding
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: apoptotic process, cellular response to lipopolysaccharide, cellular response to staurosporine, ceramide biosynthetic process, defense response to bacterium, execution phase of apoptosis, fibroblast apoptotic process, heart development, leukocyte apoptotic process, lymphocyte apoptotic process, negative regulation of transcription by RNA polymerase II, neuron apoptotic process, plasma membrane repair, positive regulation of canonical NF-kappaB signal transduction, positive regulation of neuron apoptotic process, positive regulation of plasma membrane repair, protein catabolic process, protein maturation, protein poly-ADP-ribosylation, protein processing, proteolysis, pyroptotic inflammatory response, regulation of transcription by RNA polymerase II, response to UV, striated muscle cell differentiation; MF: RNA binding, aspartic-type endopeptidase activity, catalytic activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding; CC: cytoplasm, cytosol, extracellular region, extracellular space, fibrillar center, nucleoplasm, nucleus, plasma membrane
Pathways: 3q29 copy number variation syndrome, 5-Oxoprolinuria, 5-oxoprolinase deficiency, Acute viral myocarditis, Allograft Rejection, Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, AndrogenReceptor, Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis - multiple species - Homo sapiens (human), Apoptosis Modulation and Signaling, Apoptosis Modulation by HSP70, Apoptosis-related network due to altered Notch3 in ovarian cancer, BCR, Caspase Cascade in Apoptosis, E2F transcription factor network, ERK Pathway in Huntington,s Disease, Fas ligand pathway and stress induction of heat shock proteins, Gamma-Glutamyltransferase Deficiency, Gamma-glutamyl-transpeptidase deficiency, Glutathione Metabolism, Glutathione Synthetase Deficiency, HIV-1 Nef: Negative effector of Fas and TNF-alpha, Hepatitis C and Hepatocellular Carcinoma, Host-pathogen interaction of human coronaviruses - apoptosis, Legionellosis - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Nanomaterial induced apoptosis, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Nucleotide-binding Oligomerization Domain (NOD) pathway, Oncostatin M Signaling Pathway, Parkinson,s disease pathway, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Pertussis - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, Salmonella infection - Homo sapiens (human), TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway, TNF signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, TNFalpha, a6b1 and a6b4 Integrin signaling, apoptotic dna-fragmentation and tissue homeostasis, apoptotic signaling in response to dna damage, b cell survival pathway, caspase cascade in apoptosis, fas signaling pathway (cd95), hiv-1 nef: negative effector of fas and tnf, induction of apoptosis through dr3 and dr4/5 death receptors, internal ribosome entry pathway, regulation of cell cycle progression by plk3, trefoil factors initiate mucosal healing, west nile virus
UniProt: P55210
Entrez ID: 840
|
Does Knockout of GSTT2B in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
GSTT2B
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: GSTT2B (glutathione S-transferase theta 2B)
Type: protein-coding
Summary: The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015].
Gene Ontology: MF: glutathione transferase activity, protein binding, transferase activity; CC: cytoplasm, cytosol, extracellular exosome
Pathways: Biological oxidations, Chemical carcinogenesis - Homo sapiens (human), Drug metabolism - cytochrome P450 - Homo sapiens (human), Drug metabolism - other enzymes - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), Glutathione conjugation, Glutathione metabolism - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human), Metapathway biotransformation Phase I and II, Pathways in cancer - Homo sapiens (human), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: P0CG30
Entrez ID: 653689
|
Does Knockout of KRTAP12-1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
KRTAP12-1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: KRTAP12-1 (keratin associated protein 12-1)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: P59990
Entrez ID: 353332
|
Does Knockout of GTF2E1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
GTF2E1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: GTF2E1 (general transcription factor IIE subunit 1)
Type: protein-coding
Summary: Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of transcription factor TFIID complex and transcription preinitiation complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: RNA polymerase II general transcription initiation factor activity, metal ion binding, protein binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIE complex
Pathways: Basal transcription factors - Homo sapiens (human), Disease, Eukaryotic Transcription Initiation, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Transcription of the HIV genome, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), carm1 and regulation of the estrogen receptor, chromatin remodeling by hswi/snf atp-dependent complexes, the information processing pathway at the ifn beta enhancer
UniProt: P29083
Entrez ID: 2960
|
Does Knockout of TRIM2 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
TRIM2
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: TRIM2 (tripartite motif containing 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, proteasome-mediated ubiquitin-dependent protein catabolic process, protein polyubiquitination, protein ubiquitination, regulation of neuron apoptotic process; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm
Pathways: Cytokine Signaling in Immune system, Immune System, Interferon Signaling, Interferon gamma signaling
UniProt: Q9C040
Entrez ID: 23321
|
Does Knockout of TICRR in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
TICRR
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: TICRR (TOPBP1 interacting checkpoint and replication regulator)
Type: protein-coding
Summary: Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, regulation of DNA-templated DNA replication initiation, response to ionizing radiation; MF: chromatin binding, protein binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Transition, Mitotic G2-G2/M phases
UniProt: Q7Z2Z1
Entrez ID: 90381
|
Does Knockout of EFNA1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
EFNA1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: EFNA1 (ephrin A1)
Type: protein-coding
Summary: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: angiogenesis, aortic valve morphogenesis, axon guidance, cell migration, cell-cell signaling, central nervous system neuron differentiation, endocardial cushion to mesenchymal transition involved in heart valve formation, ephrin receptor signaling pathway, mitral valve morphogenesis, negative regulation of MAPK cascade, negative regulation of dendritic spine morphogenesis, negative regulation of epithelial to mesenchymal transition, negative regulation of macromolecule metabolic process, negative regulation of proteolysis involved in protein catabolic process, negative regulation of thymocyte apoptotic process, negative regulation of transcription by RNA polymerase II, notochord formation, positive regulation of MAPK cascade, positive regulation of amyloid precursor protein catabolic process, positive regulation of amyloid-beta formation, positive regulation of intracellular signal transduction, positive regulation of peptidyl-tyrosine phosphorylation, protein stabilization, regulation of angiogenesis, regulation of axonogenesis, regulation of biological quality, regulation of blood vessel endothelial cell migration, regulation of cell adhesion mediated by integrin, regulation of peptidyl-tyrosine phosphorylation, substrate adhesion-dependent cell spreading; MF: ephrin receptor binding, protein binding, signaling receptor binding; CC: extracellular region, membrane, plasma membrane, side of membrane
Pathways: Arf6 signaling events, Axon guidance, Axon guidance - Homo sapiens (human), Cell migration and invasion through p75NTR, Developmental Biology, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHA forward signaling, EPHA-mediated growth cone collapse, EPHA2 forward signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, HIF-2-alpha transcription factor network, MAPK signaling pathway - Homo sapiens (human), MicroRNAs in cancer - Homo sapiens (human), Nervous system development, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Stabilization and expansion of the E-cadherin adherens junction
UniProt: P20827
Entrez ID: 1942
|
Does Knockout of SLC7A6OS in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
SLC7A6OS
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SLC7A6OS (solute carrier family 7 member 6 opposite strand)
Type: protein-coding
Summary: Predicted to be involved in developmental process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm and nucleus. Implicated in progressive myoclonus epilepsy. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: developmental process, hematopoietic progenitor cell differentiation, protein transport; CC: cytoplasm, nucleus
Pathways:
UniProt: Q96CW6
Entrez ID: 84138
|
Does Knockout of KRTAP10-2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
KRTAP10-2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: KRTAP10-2 (keratin associated protein 10-2)
Type: protein-coding
Summary: This gene encodes a member of the high sulfur-type keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. This gene is located in a cluster of similar genes on 21q22.3. Alternatively-spliced transcript variants have been identified. [provided by RefSeq, Jan 2015].
Gene Ontology: CC: cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization, Vitamin D Receptor Pathway
UniProt: P60368
Entrez ID: 386679
|
Does Knockout of MAP1LC3C in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
MAP1LC3C
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: MAP1LC3C (microtubule associated protein 1 light chain 3 gamma)
Type: protein-coding
Summary: Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: aggrephagy, autophagosome assembly, autophagosome maturation, autophagy, cellular response to nitrogen starvation, cellular response to starvation, macroautophagy, mitophagy, protein exit from endoplasmic reticulum, response to stress; MF: phosphatidylethanolamine binding, phospholipid binding, protein binding, ubiquitin protein ligase binding; CC: autophagosome, autophagosome membrane, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic vesicle, cytoskeleton, cytosol, endomembrane system, membrane, microtubule, organelle membrane
Pathways: Autophagy, Ferroptosis, Ferroptosis - Homo sapiens (human), Macroautophagy, Senescence and Autophagy in Cancer
UniProt: Q9BXW4
Entrez ID: 440738
|
Does Knockout of COL27A1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
COL27A1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: COL27A1 (collagen type XXVII alpha 1 chain)
Type: protein-coding
Summary: This gene encodes a member of the fibrillar collagen family, and plays a role during the calcification of cartilage and the transition of cartilage to bone. The encoded protein product is a preproprotein. It includes an N-terminal signal peptide, which is followed by an N-terminal propetide, mature peptide and a C-terminal propeptide. The N-terminal propeptide contains thrombospondin N-terminal-like and laminin G-like domains. The mature peptide is a major triple-helical region. The C-terminal propeptide, also known as COLFI domain, plays crucial roles in tissue growth and repair. Mutations in this gene cause Steel syndrome. Alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: extracellular matrix organization, growth plate cartilage chondrocyte development, skeletal system development; MF: extracellular matrix structural constituent, extracellular matrix structural constituent conferring tensile strength, metal ion binding; CC: collagen trimer, endoplasmic reticulum lumen, extracellular matrix, extracellular region, fibrillar collagen trimer
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen formation, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Pancreatic Ductal Cells, Extracellular matrix organization, MET activates PTK2 signaling, MET promotes cell motility, Protein digestion and absorption - Homo sapiens (human), Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases
UniProt: Q8IZC6
Entrez ID: 85301
|
Does Knockout of FAM163A in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
FAM163A
|
cell proliferation
|
T-lymphoma cell line
|
Gene: FAM163A (family with sequence similarity 163 member A)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q96GL9
Entrez ID: 148753
|
Does Knockout of PSMD12 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
PSMD12
|
cell proliferation
|
Melanoma Cell Line
|
Gene: PSMD12 (proteasome 26S subunit, non-ATPase 12)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: CC: cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, nucleoplasm, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, lid subcomplex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: O00232
Entrez ID: 5718
|
Does Knockout of CENPL in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
CENPL
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: CENPL (centromere protein L)
Type: protein-coding
Summary: CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008].
Gene Ontology: CC: chromosome, chromosome, centromeric region, cytosol, inner kinetochore, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8N0S6
Entrez ID: 91687
|
Does Knockout of CHCHD10 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
CHCHD10
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CHCHD10 (coiled-coil-helix-coiled-coil-helix domain containing 10)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein that is enriched at cristae junctions in the intermembrane space. It may play a role in cristae morphology maintenance or oxidative phosphorylation. Mutations in this gene cause frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7 and 19. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: inner mitochondrial membrane organization, maintenance of protein location in nucleus, maintenance of synapse structure, mitochondria-nucleus signaling pathway, mitochondrial membrane organization, mitochondrion organization, positive regulation of mitochondrial transcription, stabilization of membrane potential; MF: molecular_function, protein binding; CC: MICOS complex, mitochondrial intermembrane space, mitochondrion, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Mitochondrial protein import, Protein localization
UniProt: Q8WYQ3
Entrez ID: 400916
|
Does Knockout of BCAS3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
BCAS3
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: BCAS3 (BCAS3 microtubule associated cell migration factor)
Type: protein-coding
Summary: Enables several functions, including acetyltransferase activator activity; beta-tubulin binding activity; and histone acetyltransferase binding activity. Involved in cellular response to estrogen stimulus; positive regulation of catalytic activity; and positive regulation of transcription by RNA polymerase II. Located in nucleus; phagophore assembly site; and transcriptionally active chromatin. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: angiogenesis, autophagy, cell-cell signaling, cellular response to estrogen stimulus, positive regulation of catalytic activity, positive regulation of endothelial cell migration, positive regulation of transcription by RNA polymerase II, regulation of actin cytoskeleton organization, response to estrogen, response to starvation; MF: acetyltransferase activator activity, beta-tubulin binding, chromatin binding, histone acetyltransferase binding, histone binding, nuclear receptor binding, phosphatidylinositol binding, protein binding; CC: cell leading edge, cytoplasm, cytoplasmic microtubule, cytoskeleton, euchromatin, intermediate filament cytoskeleton, nucleus, phagophore assembly site
Pathways: Ectoderm Differentiation
UniProt: Q9H6U6
Entrez ID: 54828
|
Does Knockout of MBNL1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
MBNL1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: MBNL1 (muscleblind like splicing regulator 1)
Type: protein-coding
Summary: This gene encodes a member of the muscleblind protein family which was initially described in Drosophila melanogaster. The encoded protein is a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Mice lacking this gene exhibited muscle abnormalities and cataracts. Several alternatively spliced transcript variants have been described but the full-length natures of only some have been determined. The different isoforms are thought to have different binding specificities and/or splicing activities. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: RNA splicing, embryonic limb morphogenesis, in utero embryonic development, mRNA processing, myoblast differentiation, nervous system development, regulation of RNA splicing; MF: RNA binding, double-stranded RNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, nucleoplasm, nucleus
Pathways: Adipogenesis
UniProt: Q9NR56
Entrez ID: 4154
|
Does Knockout of TMEM18 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
TMEM18
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: TMEM18 (transmembrane protein 18)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Involved in cell migration. Located in nuclear membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell migration, eating behavior, energy homeostasis; MF: DNA binding, protein binding; CC: cytoplasm, membrane, nuclear membrane, nucleus
Pathways:
UniProt: Q96B42
Entrez ID: 129787
|
Does Knockout of CCDC137 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
CCDC137
|
response to virus
|
Hepatoma Cell Line
|
Gene: CCDC137 (coiled-coil domain containing 137)
Type: protein-coding
Summary: Enables RNA binding activity. Located in chromosome and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protein binding; CC: chromosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q6PK04
Entrez ID: 339230
|
Does Knockout of RPS13 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
RPS13
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: RPS13 (ribosomal protein S13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, negative regulation of RNA splicing, ribosomal small subunit biogenesis, translation; MF: RNA binding, mRNA 5'-UTR binding, mRNA binding, protein binding, small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome, small-subunit processome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, TNFalpha, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62277
Entrez ID: 6207
|
Does Knockout of PIANP in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
PIANP
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: PIANP (PILR alpha associated neural protein)
Type: protein-coding
Summary: This gene encodes a ligand for the paired immunoglobin-like type 2 receptor alpha, and so may be involved in immune regulation. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: cerebellum development, dentate gyrus development, gamma-aminobutyric acid signaling pathway, gene expression, glutamate secretion, homeostasis of number of cells, regulation of immune response, response to stress, social behavior, visual learning; MF: protein binding, protein domain specific binding; CC: basolateral plasma membrane, membrane, plasma membrane, presynapse
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
UniProt: Q8IYJ0
Entrez ID: 196500
|
Does Knockout of CDYL in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
CDYL
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: CDYL (chromodomain Y like)
Type: protein-coding
Summary: Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, negative regulation of peptidyl-lysine crotonylation, random inactivation of X chromosome, spermatid development, spermatogenesis; MF: chromatin binding, crotonyl-CoA hydratase activity, identical protein binding, lyase activity, protein binding, protein-macromolecule adaptor activity, transcription corepressor activity; CC: chromosome, cytoplasm, nuclear speck, nucleus
Pathways:
UniProt: Q9Y232
Entrez ID: 9425
|
Does Knockout of WASHC2A in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
WASHC2A
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: WASHC2A (WASH complex subunit 2A)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol phosphate binding activity and retromer complex binding activity. Involved in protein localization to endosome. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endosomal transport, protein localization to endosome, protein transport, regulation of Arp2/3 complex-mediated actin nucleation, retrograde transport, endosome to Golgi; MF: lipid binding, phosphatidylinositol phosphate binding, protein binding, retromer complex binding; CC: WASH complex, cytosol, early endosome, early endosome membrane, endosome, membrane, nucleolus, plasma membrane
Pathways: Endocytosis - Homo sapiens (human)
UniProt: Q641Q2
Entrez ID: 387680
|
Does Knockout of HSPD1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
HSPD1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: HSPD1 (heat shock protein family D (Hsp60) member 1)
Type: protein-coding
Summary: This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: 'de novo' protein folding, B cell activation, B cell proliferation, MyD88-dependent toll-like receptor signaling pathway, T cell activation, adhesion of symbiont to host, apoptotic mitochondrial changes, biological process involved in interaction with symbiont, cellular response to interleukin-7, chaperone-mediated protein complex assembly, isotype switching to IgG isotypes, mitochondrial unfolded protein response, negative regulation of apoptotic process, negative regulation of execution phase of apoptosis, positive regulation of T cell activation, positive regulation of T cell mediated immune response to tumor cell, positive regulation of cytokine production, positive regulation of execution phase of apoptosis, positive regulation of interferon-alpha production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of macrophage activation, positive regulation of type II interferon production, protein folding, protein import into mitochondrial intermembrane space, protein maturation, protein refolding, protein stabilization, response to cold, response to unfolded protein; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, DNA replication origin binding, RNA binding, apolipoprotein A-I binding, apolipoprotein binding, cysteine-type endopeptidase activator activity, double-stranded RNA binding, enzyme binding, high-density lipoprotein particle binding, isomerase activity, lipopolysaccharide binding, nucleotide binding, p53 binding, protein binding, protein-folding chaperone binding, single-stranded DNA binding, ubiquitin protein ligase binding, unfolded protein binding; CC: cell surface, clathrin-coated pit, coated vesicle, cytoplasm, cytosol, early endosome, extracellular exosome, extracellular space, intracellular membrane-bounded organelle, lipopolysaccharide receptor complex, membrane, migrasome, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, plasma membrane, protein-containing complex, secretory granule, sperm midpiece, sperm plasma membrane
Pathways: Apoptosis-related network due to altered Notch3 in ovarian cancer, Cellular responses to stimuli, Cellular responses to stress, Endogenous TLR signaling, Gene expression (Transcription), Generic Transcription Pathway, Legionellosis - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial protein import, Mitochondrial unfolded protein response (UPRmt), Protein localization, RNA Polymerase II Transcription, RNA degradation - Homo sapiens (human), Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Tuberculosis - Homo sapiens (human), Type I diabetes mellitus - Homo sapiens (human), Validated targets of C-MYC transcriptional activation
UniProt: P10809
Entrez ID: 3329
|
Does Knockout of ATP6V1G1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
ATP6V1G1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: ATP6V1G1 (ATPase H+ transporting V1 subunit G1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to increased oxygen levels, intracellular iron ion homeostasis, monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification; MF: ATP hydrolysis activity, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: ATPase complex, apical plasma membrane, cytosol, extracellular exosome, extrinsic component of synaptic vesicle membrane, lysosomal membrane, membrane, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Osteoclast Signaling, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, mTOR signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: O75348
Entrez ID: 9550
|
Does Knockout of DEFA5 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
DEFA5
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: DEFA5 (defensin alpha 5)
Type: protein-coding
Summary: Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, defense response to fungus, disruption of plasma membrane integrity in another organism, immune system process, innate immune response, killing by host of symbiont cells, killing of cells of another organism, positive regulation of interleukin-8 production, positive regulation of membrane permeability, protein homotetramerization; MF: pore-forming activity, protein binding, protein homodimerization activity; CC: Golgi lumen, cytoplasmic vesicle, extracellular region, extracellular space, midbody, secretory granule, secretory granule lumen, transport vesicle
Pathways: Alpha-defensins, Antimicrobial peptides, Cellular responses to stimuli, Cellular responses to stress, Defensins, Immune System, Innate Immune System, Mitochondrial unfolded protein response (UPRmt), NOD-like receptor signaling pathway - Homo sapiens (human), Staphylococcus aureus infection - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: Q01523
Entrez ID: 1670
|
Does Knockout of ELOB in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
ELOB
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: ELOB (elongin B)
Type: protein-coding
Summary: This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination, protein-containing complex assembly, target-directed miRNA degradation, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: protein binding, transcription corepressor binding, ubiquitin protein ligase binding; CC: Cul2-RING ubiquitin ligase complex, Cul5-RING ubiquitin ligase complex, VCB complex, cytoplasm, cytosol, elongin complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Dual hijack model of Vif in HIV infection, HIF-1 signaling pathway - Homo sapiens (human), HIF-2-alpha transcription factor network, Hijack of ubiquitination by SARS-CoV-2, Human immunodeficiency virus 1 infection - Homo sapiens (human), Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, Modulators of TCR signaling and T cell activation, Pathways in cancer - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), Type 2 papillary renal cell carcinoma, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q15370
Entrez ID: 6923
|
Does Knockout of CCDC86 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
CCDC86
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: CCDC86 (coiled-coil domain containing 86)
Type: protein-coding
Summary: Enables RNA binding activity. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromosome segregation, mitotic nuclear division; MF: RNA binding, protein binding; CC: chromosome, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9H6F5
Entrez ID: 79080
|
Does Knockout of PSMC3 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
PSMC3
|
response to virus
|
Lung Cancer Cell Line
|
Gene: PSMC3 (proteasome 26S subunit, ATPase 3)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: blastocyst development, host-mediated perturbation of viral transcription, positive regulation of proteasomal protein catabolic process, positive regulation of transcription by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ATP binding, ATP hydrolysis activity, identical protein binding, nucleotide binding, proteasome-activating activity, protein binding; CC: P-body, cytoplasm, cytosol, extracellular region, ficolin-1-rich granule lumen, membrane, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P17980
Entrez ID: 5702
|
Does Knockout of GAR1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
GAR1
|
cell proliferation
|
Cancer Cell Line
|
Gene: GAR1 (GAR1 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: pseudouridine synthesis, rRNA processing, ribosome biogenesis, snoRNA guided rRNA pseudouridine synthesis, telomere maintenance via telomerase; MF: RNA binding, box H/ACA snoRNA binding, protein binding, telomerase RNA binding; CC: Cajal body, box H/ACA scaRNP complex, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, chromosome, telomeric region, fibrillar center, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q9NY12
Entrez ID: 54433
|
Does Knockout of SEC13 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
SEC13
|
cell proliferation
|
Cancer Cell Line
|
Gene: SEC13 (SEC13 homolog, nuclear pore and COPII component)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: COPII-coated vesicle budding, COPII-coated vesicle cargo loading, cellular response to nutrient levels, intracellular protein transport, mRNA transport, negative regulation of TORC1 signaling, nucleocytoplasmic transport, positive regulation of TOR signaling, positive regulation of TORC1 signaling, protein exit from endoplasmic reticulum, protein import into nucleus, protein transport, vesicle-mediated transport; MF: identical protein binding, protein binding, structural molecule activity; CC: COPII vesicle coat, ER to Golgi transport vesicle membrane, GATOR2 complex, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, kinetochore, lysosomal membrane, lysosome, membrane, nuclear envelope, nuclear pore, nuclear pore outer ring, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), RNA transport - Homo sapiens (human), Sterol regulatory element-binding proteins (SREBP) signaling, mTOR signaling pathway - Homo sapiens (human)
UniProt: P55735
Entrez ID: 6396
|
Does Knockout of SLC27A6 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
SLC27A6
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: SLC27A6 (solute carrier family 27 member 6)
Type: protein-coding
Summary: This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: fatty acid metabolic process, lipid metabolic process, lipid transport, long-chain fatty acid import into cell, long-chain fatty acid metabolic process, long-chain fatty acid transport, very long-chain fatty acid metabolic process; MF: arachidonate-CoA ligase activity, fatty acid transmembrane transporter activity, ligase activity, long-chain fatty acid transmembrane transporter activity, long-chain fatty acid-CoA ligase activity, nucleotide binding, very long-chain fatty acid-CoA ligase activity; CC: endoplasmic reticulum membrane, membrane, plasma membrane, sarcolemma
Pathways: Insulin resistance - Homo sapiens (human), PPAR signaling pathway, PPAR signaling pathway - Homo sapiens (human), SLC-mediated transmembrane transport, Transport of fatty acids, Transport of small molecules, Transport of vitamins, nucleosides, and related molecules
UniProt: Q9Y2P4
Entrez ID: 28965
|
Does Activation of NHLRC2 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
NHLRC2
|
protein/peptide accumulation
|
T cell
|
Gene: NHLRC2 (NHL repeat containing 2)
Type: protein-coding
Summary: Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, cytosol, extracellular region, platelet alpha granule lumen
Pathways:
UniProt: Q8NBF2
Entrez ID: 374354
|
Does Knockout of CUL5 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
CUL5
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CUL5 (cullin 5)
Type: protein-coding
Summary: Enables ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within cerebral cortex radially oriented cell migration and radial glia guided migration of Purkinje cell. Located in site of DNA damage. Part of Cul5-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERBB2 signaling pathway, G1/S transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, cGAS/STING signaling pathway, calcium ion transmembrane transport, cell migration, defense response to virus, endoplasmic reticulum unfolded protein response, epithelial to mesenchymal transition, erythropoietin-mediated signaling pathway, growth hormone receptor signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, innate immune response, intrinsic apoptotic signaling pathway, layer formation in cerebral cortex, negative regulation of cGAS/STING signaling pathway, negative regulation of epithelial to mesenchymal transition, negative regulation of focal adhesion assembly, negative regulation of focal adhesion disassembly, negative regulation of growth hormone receptor signaling pathway, positive regulation of cell migration, positive regulation of focal adhesion assembly, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein ubiquitination, reelin-mediated signaling pathway, regulation of neuron migration, signal transduction, symbiont-mediated suppression of host innate immune response, ubiquitin-dependent protein catabolic process; MF: calcium channel activity, protein binding, protein-macromolecule adaptor activity, signaling receptor activity, ubiquitin ligase complex scaffold activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity; CC: Cul5-RING ubiquitin ligase complex, SCF ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleus, site of DNA damage
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis-related network due to altered Notch3 in ovarian cancer, Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Disease, Downregulation of ERBB2 signaling, Dual hijack model of Vif in HIV infection, Evasion by RSV of host interferon responses, HIV Infection, Host Interactions of HIV factors, Human immunodeficiency virus 1 infection - Homo sapiens (human), Immune System, Inactivation of CSF3 (G-CSF) signaling, Infectious disease, Metabolism of proteins, Modulators of TCR signaling and T cell activation, Neddylation, Post-translational protein modification, RSV-host interactions, Respiratory Syncytial Virus Infection Pathway, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by ERBB2, Signaling by Receptor Tyrosine Kinases, Ubiquitin mediated proteolysis - Homo sapiens (human), Vif-mediated degradation of APOBEC3G, Viral Infection Pathways
UniProt: Q93034
Entrez ID: 8065
|
Does Knockout of SEPSECS in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
SEPSECS
|
cell proliferation
|
Melanoma Cell Line
|
Gene: SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase)
Type: protein-coding
Summary: The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).[provided by RefSeq, Mar 2011].
Gene Ontology: BP: conversion of seryl-tRNAsec to selenocys-tRNAsec, selenocysteine incorporation, translation; MF: O-phosphoseryl-tRNA(Sec) selenium transferase activity, RNA binding, protein binding, tRNA binding, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Metabolism, Metabolism of amino acids and derivatives, Selenoamino acid metabolism, Selenocompound metabolism - Homo sapiens (human), Selenocysteine synthesis, selenocysteine biosynthesis
UniProt: Q9HD40
Entrez ID: 51091
|
Does Knockout of TDRD12 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
TDRD12
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: TDRD12 (tudor domain containing 12)
Type: protein-coding
Summary: Predicted to enable ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be involved in several processes, including gamete generation; gene silencing by RNA; and piRNA metabolic process. Predicted to be part of PET complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, fertilization, germ-line stem cell division, male meiotic nuclear division, meiotic cell cycle, piRNA processing, regulatory ncRNA-mediated gene silencing, spermatogenesis, transposable element silencing by piRNA-mediated DNA methylation; MF: ATP binding, ATP hydrolysis activity, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding
Pathways: Gene Silencing by RNA, Gene expression (Transcription), PIWI-interacting RNA (piRNA) biogenesis
UniProt: Q587J7
Entrez ID: 91646
|
Does Knockout of AMOTL1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
AMOTL1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: AMOTL1 (angiomotin like 1)
Type: protein-coding
Summary: The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: Wnt signaling pathway, actin cytoskeleton organization, angiogenesis, establishment of cell polarity involved in ameboidal cell migration, hippo signaling, regulation of cell migration; MF: identical protein binding, protein binding; CC: COP9 signalosome, anchoring junction, bicellular tight junction, cytoplasmic vesicle, cytosol, plasma membrane
Pathways: Signal Transduction, Signaling by Hippo, Tight junction - Homo sapiens (human)
UniProt: Q8IY63
Entrez ID: 154810
|
Does Knockout of TAF1C in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
TAF1C
|
cell proliferation
|
Bladder Carcinoma
|
Gene: TAF1C (TATA-box binding protein associated factor, RNA polymerase I subunit C)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, transcription by RNA polymerase I, transcription by RNA polymerase II, transcription initiation at RNA polymerase I promoter; MF: DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, RNA polymerase I general transcription initiation factor activity, protein binding; CC: RNA polymerase transcription factor SL1 complex, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, SIRT1 negatively regulates rRNA expression
UniProt: Q15572
Entrez ID: 9013
|
Does Knockout of BRIX1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
BRIX1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: BRIX1 (biogenesis of ribosomes BRX1)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in ribosomal large subunit assembly. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: rRNA processing, ribosomal large subunit assembly, ribosome biogenesis; MF: RNA binding, protein binding, rRNA binding; CC: chromosome, nucleolus, nucleus
Pathways: Gastric Cancer Network 2
UniProt: Q8TDN6
Entrez ID: 55299
|
Does Knockout of MAP2K4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
MAP2K4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MAP2K4 (mitogen-activated protein kinase kinase 4)
Type: protein-coding
Summary: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: Fc-epsilon receptor signaling pathway, JNK cascade, MAPK cascade, apoptotic process, cellular response to mechanical stimulus, cellular response to stress, cellular senescence, intrinsic apoptotic signaling pathway in response to hydrogen peroxide, negative regulation of motor neuron apoptotic process, response to wounding, signal transduction, smooth muscle cell apoptotic process; MF: ATP binding, JUN kinase kinase activity, MAP kinase kinase activity, kinase activity, molecular adaptor activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, Apoptosis, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Bacterial Infection Pathways, CD40/CD40L signaling, CDC42 signaling events, Cardiac Hypertrophic Response, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular roles of Anthrax toxin, Ceramide signaling pathway, Chagas disease - Homo sapiens (human), Cytokine Signaling in Immune system, Disease, Ephrin B reverse signaling, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Epithelial to mesenchymal transition in colorectal cancer, Epstein-Barr virus infection - Homo sapiens (human), ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), ErbB1 downstream signaling, FCERI mediated MAPK activation, Fas ligand pathway and stress induction of heat shock proteins, Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), Fc epsilon receptor (FCERI) signaling, Fc-epsilon receptor I signaling in mast cells, Fluid shear stress and atherosclerosis - Homo sapiens (human), Glioblastoma signaling pathways, GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Host-pathogen interaction of human coronaviruses - MAPK signaling, Human T-cell leukemia virus 1 infection - Homo sapiens (human), IL-1 signaling pathway, IL-6 signaling pathway, IL1, IL6, IL6-mediated signaling events, Immune System, Infectious disease, Innate Immune System, Insulin Signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, JNK signaling in the CD4+ TCR pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK Cascade, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Nephrin/Neph1 signaling in the kidney podocyte, Oxidative Damage, Oxidative Stress Induced Senescence, PDGF Pathway, PDGFR-beta signaling pathway, RAC1 signaling pathway, Regulation of Androgen receptor activity, Regulation of p38-alpha and p38-beta, Regulation of toll-like receptor signaling pathway, Relaxin signaling pathway - Homo sapiens (human), RhoA signaling pathway, Salmonella infection - Homo sapiens (human), Signaling by Interleukins, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by focal adhesion kinase, Structural Pathway of Interleukin 1 (IL-1), TGF-beta Signaling Pathway, TNF signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAIL signaling pathway, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like Receptor Signaling Pathway, Toll-like receptor signaling pathway - Homo sapiens (human), Translation inhibitors in chronically activated PDGFRA cells, Uptake and actions of bacterial toxins, Uptake and function of anthrax toxins, VEGFA-VEGFR2 Signaling Pathway, VEGFR3 signaling in lymphatic endothelium, Wnt signaling pathway and pluripotency, Yersinia infection - Homo sapiens (human), angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling, ceramide signaling pathway, egf signaling pathway, fas signaling pathway (cd95), fc epsilon receptor i signaling in mast cells, inhibition of cellular proliferation by gleevec, keratinocyte differentiation, links between pyk2 and map kinases, map kinase inactivation of smrt corepressor, mapkinase signaling pathway, p38 MAPK Signaling Pathway, p38 mapk signaling pathway, pdgf signaling pathway, t cell receptor signaling pathway, tnf/stress related signaling, tnfr1 signaling pathway, toll-like receptor pathway
UniProt: P45985
Entrez ID: 6416
|
Does Knockout of CCAR2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
CCAR2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CCAR2 (cell cycle and apoptosis regulator 2)
Type: protein-coding
Summary: Enables RNA polymerase II complex binding activity and enzyme inhibitor activity. Involved in several processes, including regulation of cellular protein metabolic process; regulation of signal transduction; and regulation of transcription, DNA-templated. Located in several cellular components, including mitochondrial matrix; nucleoplasm; and spindle. Part of DBIRD complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, RNA splicing, Wnt signaling pathway, apoptotic process, mRNA processing, mitochondrial fragmentation involved in apoptotic process, negative regulation of DNA-templated transcription, negative regulation of catalytic activity, negative regulation of cell growth, negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of DNA damage checkpoint, positive regulation of apoptotic process, positive regulation of canonical Wnt signaling pathway, regulation of DNA-templated transcription, regulation of DNA-templated transcription elongation, regulation of circadian rhythm, regulation of protein deacetylation, regulation of protein stability, response to UV, rhythmic process; MF: RNA binding, RNA polymerase II complex binding, adenyl-nucleotide exchange factor activity, enzyme binding, enzyme inhibitor activity, protein binding, unfolded protein binding; CC: DBIRD complex, chromatin, cytoplasm, cytoskeleton, mitochondrial matrix, nucleoplasm, nucleus, spindle
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: Q8N163
Entrez ID: 57805
|
Does Activation of MICA in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
MICA
|
protein/peptide accumulation
|
T cell
|
Gene: MICA (MHC class I polypeptide-related sequence A)
Type: protein-coding
Summary: This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: DNA damage response, T cell mediated cytotoxicity, adaptive immune response, defense response to bacterium, defense response to virus, gamma-delta T cell activation, immune response, immune response to tumor cell, immune system process, killing of cells of another organism, natural killer cell mediated cytotoxicity, negative regulation of defense response, negative regulation of natural killer cell activation, negative regulation of natural killer cell mediated cytotoxicity, regulation of immune response, response to heat, signal transduction; MF: beta-2-microglobulin binding, natural killer cell lectin-like receptor binding, protein binding, receptor ligand activity; CC: cell surface, cytoplasm, external side of plasma membrane, extracellular space, membrane, plasma membrane
Pathways: Adaptive Immune System, Allograft Rejection, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Natural killer cell mediated cytotoxicity - Homo sapiens (human)
UniProt: Q29983
Entrez ID: 100507436
|
Does Knockout of NOP16 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
NOP16
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: NOP16 (NOP16 nucleolar protein)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9Y3C1
Entrez ID: 51491
|
Does Knockout of NUP43 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
NUP43
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: NUP43 (nucleoporin 43)
Type: protein-coding
Summary: Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell division, chromosome segregation, mRNA transport, nucleocytoplasmic transport, protein transport; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, nuclear envelope, nuclear pore, nuclear pore outer ring, nuclear speck, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, EML4 and NUDC in mitotic spindle formation, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q8NFH3
Entrez ID: 348995
|
Does Knockout of FOXI2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
FOXI2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: FOXI2 (forkhead box I2)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: Q6ZQN5
Entrez ID: 399823
|
Does Knockout of HPCAL4 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
HPCAL4
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: HPCAL4 (hippocalcin like 4)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: central nervous system development, regulation of signal transduction, response to heat; MF: calcium channel regulator activity, calcium ion binding, metal ion binding, protein binding, protein domain specific binding
Pathways:
UniProt: Q9UM19
Entrez ID: 51440
|
Does Knockout of RPL41 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
RPL41
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: RPL41 (ribosomal protein L41)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, endoplasmic reticulum, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62945
Entrez ID: 6171
|
Does Knockout of PAGE1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
PAGE1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PAGE1 (PAGE family member 1)
Type: protein-coding
Summary: This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. Unlike the other gene family members, this gene does not encode an antigenic peptide. Nothing is presently known about the function of this protein. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways:
UniProt: O75459
Entrez ID: 8712
|
Does Knockout of MRPL27 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
MRPL27
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: MRPL27 (mitochondrial ribosomal protein L27)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9P0M9
Entrez ID: 51264
|
Does Knockout of PLA2G10 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
PLA2G10
|
cell proliferation
|
Bladder Carcinoma
|
Gene: PLA2G10 (phospholipase A2 group X)
Type: protein-coding
Summary: This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: arachidonate metabolic process, arachidonate secretion, axon guidance, cellular response to leukemia inhibitory factor, cholesterol homeostasis, defense response to virus, erythrocyte maturation, fertilization, hair follicle morphogenesis, intestinal stem cell homeostasis, lipid catabolic process, lipid metabolic process, low-density lipoprotein particle remodeling, lysophospholipid transport, macrophage activation, negative regulation of cholesterol efflux, negative regulation of cytokine production involved in inflammatory response, negative regulation of inflammatory response, negative regulation of transcription by RNA polymerase II, nuclear receptor-mediated signaling pathway, phosphatidic acid metabolic process, phosphatidylcholine catabolic process, phosphatidylcholine metabolic process, phosphatidylethanolamine metabolic process, phosphatidylglycerol metabolic process, phosphatidylserine metabolic process, phospholipid metabolic process, platelet activating factor catabolic process, positive regulation of acrosome reaction, positive regulation of arachidonate secretion, positive regulation of lipid storage, positive regulation of macrophage derived foam cell differentiation, positive regulation of prostaglandin secretion, positive regulation of protein metabolic process, production of molecular mediator involved in inflammatory response, prostaglandin biosynthetic process, regulation of macrophage activation, signal transduction involved in regulation of gene expression; MF: 1-alkyl-2-acetylglycerophosphocholine esterase activity, calcium ion binding, calcium-dependent phospholipase A2 activity, hydrolase activity, metal ion binding, phospholipase A2 activity, phospholipase activity, phospholipid binding, protein binding; CC: acrosomal vesicle, cytoplasmic vesicle, extracellular region, extracellular space, lysosome
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Acyl chain remodelling of PG, Acyl chain remodelling of PI, Acyl chain remodelling of PS, Arachidonic acid metabolism - Homo sapiens (human), Ether lipid metabolism - Homo sapiens (human), Fat digestion and absorption - Homo sapiens (human), Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Linoleic acid metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, Pancreatic secretion - Homo sapiens (human), Phospholipid metabolism, Ras signaling, Ras signaling pathway - Homo sapiens (human), Synthesis of PA, Vascular smooth muscle contraction - Homo sapiens (human), alpha-Linolenic acid metabolism - Homo sapiens (human), phospholipases
UniProt: O15496
Entrez ID: 8399
|
Does Knockout of NUP214 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
NUP214
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: NUP214 (nucleoporin 214)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: RNA export from nucleus, intracellular protein transport, mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein export from nucleus, protein import into nucleus, protein transport, regulation of cell cycle, regulation of nucleocytoplasmic transport; MF: nuclear export signal receptor activity, nuclear localization sequence binding, protein binding, structural constituent of nuclear pore; CC: cytoplasmic side of nuclear pore, cytosol, nuclear envelope, nuclear pore, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, BMP receptor signaling, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, HuR (ELAVL1) binds and stabilizes mRNA, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Regulation of cytoplasmic and nuclear SMAD2/3 signaling, Regulation of mRNA stability by proteins that bind AU-rich elements, Rev-mediated nuclear export of HIV RNA, Role of Calcineurin-dependent NFAT signaling in lymphocytes, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TGF-beta Signaling Pathway, TGF_beta_Receptor, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, snRNP Assembly, sumoylation by ranbp2 regulates transcriptional repression, tRNA processing, tRNA processing in the nucleus
UniProt: P35658
Entrez ID: 8021
|
Does Knockout of ATG16L1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
ATG16L1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ATG16L1 (autophagy related 16 like 1)
Type: protein-coding
Summary: The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010].
Gene Ontology: BP: C-terminal protein lipidation, autophagosome assembly, autophagy, axonal transport, corpus callosum development, defense response to virus, dendrite arborization, hippocampus development, macroautophagy, microautophagy, negative regulation of dendrite extension, negative stranded viral RNA replication, positive regulation of autophagy, protein localization to phagophore assembly site, protein transport, xenophagy; MF: GTPase binding, identical protein binding, protein binding, protein-membrane adaptor activity, ubiquitin-like protein transferase activity; CC: Atg12-Atg5-Atg16 complex, autophagosome, autophagosome membrane, axon, axoneme, cytoplasm, cytosol, endolysosome membrane, endosome, endosome membrane, glutamatergic synapse, lysosomal membrane, lysosome, membrane, phagophore assembly site membrane, sperm midpiece, synapse, vacuole-isolation membrane contact site
Pathways: Autophagy, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), LDLRAD4 and what we know about it, NOD-like receptor signaling pathway - Homo sapiens (human), Nanoparticle triggered autophagic cell death, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Senescence and Autophagy in Cancer, Shigellosis - Homo sapiens (human)
UniProt: Q676U5
Entrez ID: 55054
|
Does Knockout of MUC21 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
MUC21
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MUC21 (mucin 21, cell surface associated)
Type: protein-coding
Summary: This gene encodes a large membrane-bound glycoprotein which is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. The encoded protein contains an N-terminal signal sequence, an extracellular mucin domain, a stem domain, a transmembrane domain, and a C-terminal cytoplasmic tail domain. The mucin domain contains O-glycosylation sites and is polymorphic with isoforms containing a variable number of nonidentical proline-, threonine-, and serine-rich tandem repeats of 15 amino acids each. The aberrent expression of this gene is associated with lung adenocarcinoma. [provided by RefSeq, May 2017].
Gene Ontology: CC: Golgi lumen, membrane, plasma membrane
Pathways: C-type lectin receptors (CLRs), Dectin-2 family, Defective C1GALT1C1 causes TNPS, Defective GALNT12 causes CRCS1, Defective GALNT3 causes HFTC, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Immune System, Innate Immune System, Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, Termination of O-glycan biosynthesis
UniProt: Q5SSG8
Entrez ID: 394263
|
Does Knockout of RPL18 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
RPL18
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RPL18 (ribosomal protein L18)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, focal adhesion, membrane, nucleolus, nucleus, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q07020
Entrez ID: 6141
|
Does Knockout of PRELID3B in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
PRELID3B
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PRELID3B (PRELI domain containing 3B)
Type: protein-coding
Summary: Predicted to enable phosphatidic acid transfer activity. Predicted to be involved in phospholipid transport. Predicted to be active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intermembrane lipid transfer, phospholipid transport; MF: phosphatidic acid transfer activity, protein binding; CC: mitochondrial intermembrane space, mitochondrion
Pathways:
UniProt: Q9Y3B1
Entrez ID: 51012
|
Does Knockout of KCNJ4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
KCNJ4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: KCNJ4 (potassium inwardly rectifying channel subfamily J member 4)
Type: protein-coding
Summary: Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion import across plasma membrane, potassium ion transport, regulation of monoatomic ion transmembrane transport; MF: PDZ domain binding, inward rectifier potassium channel activity, protein binding; CC: basolateral plasma membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, monoatomic ion channel complex, plasma membrane, postsynaptic membrane, synapse, voltage-gated potassium channel complex
Pathways: Acebutolol Action Pathway, Activation of G protein gated Potassium channels, Activation of GABAB receptors, Alprenolol Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupranolol Action Pathway, Cardiac conduction, Carteolol Action Pathway, Carvedilol Action Pathway, Cholinergic synapse - Homo sapiens (human), Classical Kir channels, Diltiazem Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Epinephrine Action Pathway, Esmolol Action Pathway, Felodipine Action Pathway, Flecainide Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, G protein gated Potassium channels, GABA B receptor activation, GABA receptor activation, Ibutilide Action Pathway, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Inwardly rectifying K+ channels, Isoprenaline Action Pathway, Isradipine Action Pathway, Labetalol Action Pathway, Levobunolol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Muscle contraction, Muscle/Heart Contraction, Nadolol Action Pathway, Nebivolol Action Pathway, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Oxytocin signaling pathway - Homo sapiens (human), Penbutolol Action Pathway, Phase 4 - resting membrane potential, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Potassium Channels, Practolol Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Sotalol Action Pathway, Timolol Action Pathway, Tocainide Action Pathway, Transmission across Chemical Synapses, Verapamil Action Pathway
UniProt: P48050
Entrez ID: 3761
|
Does Knockout of PAN2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
PAN2
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: PAN2 (poly(A) specific ribonuclease subunit PAN2)
Type: protein-coding
Summary: This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: mRNA processing, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of cytoplasmic mRNA processing body assembly; MF: 3'-5'-RNA exonuclease activity, cysteine-type deubiquitinase activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, poly(A)-specific ribonuclease activity, protein binding; CC: P-body, PAN complex, cytoplasm, cytosol, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Ectoderm Differentiation, Metabolism of RNA, RNA degradation - Homo sapiens (human)
UniProt: Q504Q3
Entrez ID: 9924
|
Does Knockout of RFC3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
RFC3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: RFC3 (replication factor C subunit 3)
Type: protein-coding
Summary: The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA synthesis involved in DNA repair, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP-dependent activity, acting on DNA, DNA binding, DNA clamp loader activity, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, chromosome, nucleoplasm, nucleus, protein-containing complex
Pathways: ATR signaling pathway, Activation of ATR in response to replication stress, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Fanconi anemia pathway, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gastric Cancer Network 2, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Impaired BRCA2 binding to RAD51, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P40938
Entrez ID: 5983
|
Does Knockout of DBNDD2 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
DBNDD2
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: DBNDD2 (dysbindin domain containing 2)
Type: protein-coding
Summary: Involved in negative regulation of protein kinase activity. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERK1 and ERK2 cascade, apoptotic process, monoatomic ion homeostasis, negative regulation of protein kinase activity, neurogenesis, neuron projection development, regulation of signal transduction; MF: ATPase binding, protein binding; CC: cytoplasm, endoplasmic reticulum, lysosome
Pathways:
UniProt: Q9BQY9
Entrez ID: 55861
|
Does Knockout of NOL10 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
NOL10
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: NOL10 (nucleolar protein 10)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: nucleolus, nucleus, small-subunit processome
Pathways:
UniProt: Q9BSC4
Entrez ID: 79954
|
Does Knockout of ARHGAP30 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
ARHGAP30
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ARHGAP30 (Rho GTPase activating protein 30)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in small GTPase mediated signal transduction. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of Rho protein signal transduction, regulation of small GTPase mediated signal transduction, signal transduction, small GTPase-mediated signal transduction; MF: GTPase activator activity, protein binding; CC: cytoplasmic vesicle, cytosol
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOU GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q7Z6I6
Entrez ID: 257106
|
Does Knockout of POLR2E in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
POLR2E
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: POLR2E (RNA polymerase II, I and III subunit E)
Type: protein-coding
Summary: This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: DNA-templated transcription, protein stabilization, tRNA transcription by RNA polymerase III, transcription by RNA polymerase II, transcription elongation by RNA polymerase I; MF: DNA binding, DNA-directed RNA polymerase activity, protein binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, RNA polymerase II, core complex, RNA polymerase III complex, RPAP3/R2TP/prefoldin-like complex, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Abortive elongation of HIV-1 transcript in the absence of Tat, Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, B-WICH complex positively regulates rRNA expression, Cell Cycle, Chromosome Maintenance, Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , DNA Repair, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dual incision in TC-NER, ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, Eukaryotic Transcription Initiation, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene Silencing by RNA, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, HIV elongation arrest and recovery, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inhibition of DNA recombination at telomere, Innate Immune System, Late Phase of HIV Life Cycle, Metabolism of RNA, MicroRNA (miRNA) biogenesis, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, PIWI-interacting RNA (piRNA) biogenesis, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, Positive epigenetic regulation of rRNA expression, Processing of Capped Intron-Containing Pre-mRNA, Pyrimidine metabolism, RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Telomere Maintenance, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by small RNAs, Viral Infection Pathways, Viral Messenger RNA Synthesis, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P19388
Entrez ID: 5434
|
Does Knockout of SESN1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
SESN1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: SESN1 (sestrin 1)
Type: protein-coding
Summary: This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: cellular oxidant detoxification, cellular response to L-leucine, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to glucose starvation, cellular response to leucine starvation, negative regulation of TORC1 signaling, negative regulation of cell growth, positive regulation of macroautophagy, reactive oxygen species metabolic process, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of response to reactive oxygen species; MF: L-leucine binding, oxidoreductase activity, oxidoreductase activity, acting on peroxide as acceptor, protein binding; CC: GATOR2 complex, cytoplasm, cytosol, fibrillar center, nucleoplasm, nucleus
Pathways: DNA damage response, Direct p53 effectors, Gene expression (Transcription), Generic Transcription Pathway, Head and Neck Squamous Cell Carcinoma, Longevity regulating pathway - Homo sapiens (human), Mesodermal commitment pathway, RNA Polymerase II Transcription, TP53 Regulates Metabolic Genes, Transcriptional Regulation by TP53, miRNA regulation of DNA damage response, p53 signaling pathway - Homo sapiens (human), p53 transcriptional gene network
UniProt: Q9Y6P5
Entrez ID: 27244
|
Does Knockout of AAGAB in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
AAGAB
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: AAGAB (alpha and gamma adaptin binding protein)
Type: protein-coding
Summary: The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012].
Gene Ontology: CC: cytoplasm, cytosol, nuclear speck
Pathways:
UniProt: Q6PD74
Entrez ID: 79719
|
Does Knockout of CCDC169 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
CCDC169
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: CCDC169 (coiled-coil domain containing 169)
Type: protein-coding
Summary: coiled-coil domain containing 169
Gene Ontology:
Pathways:
UniProt: A6NNP5
Entrez ID: 728591
|
Does Knockout of COG4 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
COG4
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: COG4 (component of oligomeric golgi complex 4)
Type: protein-coding
Summary: The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010].
Gene Ontology: BP: Golgi organization, glycosylation, protein transport, retrograde transport, vesicle recycling within Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; MF: identical protein binding, protein binding; CC: Golgi apparatus, Golgi membrane, Golgi transport complex, cytoplasm, cytosol, membrane, trans-Golgi network membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9H9E3
Entrez ID: 25839
|
Does Knockout of PPCDC in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
PPCDC
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: PPCDC (phosphopantothenoylcysteine decarboxylase)
Type: protein-coding
Summary: Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: coenzyme A biosynthetic process; MF: FMN binding, carboxy-lyase activity, catalytic activity, identical protein binding, lyase activity, phosphopantothenoylcysteine decarboxylase activity, protein binding; CC: cytosol, phosphopantothenoylcysteine decarboxylase complex
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Pantothenate and CoA Biosynthesis, Pantothenate and CoA biosynthesis - Homo sapiens (human), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q96CD2
Entrez ID: 60490
|
Does Knockout of SMC3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
SMC3
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: SMC3 (structural maintenance of chromosomes 3)
Type: protein-coding
Summary: This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, cell division, chromosome organization, establishment of meiotic sister chromatid cohesion, establishment of mitotic sister chromatid cohesion, meiotic cell cycle, mitotic cell cycle, mitotic sister chromatid cohesion, mitotic spindle assembly, regulation of DNA replication, sister chromatid cohesion, stem cell population maintenance; MF: ATP binding, ATP hydrolysis activity, beta-tubulin binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, dynein complex binding, mediator complex binding, microtubule motor activity, nucleotide binding, protein binding, protein heterodimerization activity; CC: chromatin, chromosome, chromosome, centromeric region, cohesin complex, cytosol, lateral element, meiotic cohesin complex, mitotic cohesin complex, mitotic spindle pole, nuclear lumen, nuclear matrix, nucleoplasm, nucleus
Pathways: ATM pathway, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cohesin Loading onto Chromatin, ESR-mediated signaling, Establishment of Sister Chromatid Cohesion, Estrogen-dependent gene expression, M Phase, MECP2 and Associated Rett Syndrome, Meiosis, Meiotic synapsis, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Telophase/Cytokinesis, Oocyte meiosis - Homo sapiens (human), Post-translational protein modification, Prion disease pathway, Regulation of sister chromatid separation at the metaphase-anaphase transition, Reproduction, Resolution of Sister Chromatid Cohesion, Retinoblastoma gene in cancer, S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q9UQE7
Entrez ID: 9126
|
Does Knockout of RPS15 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
RPS15
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: RPS15 (ribosomal protein S15)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cytoplasmic translation, liver regeneration, osteoblast differentiation, positive regulation of signal transduction by p53 class mediator, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus, translation; MF: DNA binding, MDM2/MDM4 family protein binding, RNA binding, protein binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, focal adhesion, membrane, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62841
Entrez ID: 6209
|
Does Knockout of ZMYND8 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
ZMYND8
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: ZMYND8 (zinc finger MYND-type containing 8)
Type: protein-coding
Summary: The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin organization, double-strand break repair via homologous recombination, modulation of excitatory postsynaptic potential, negative regulation of DNA-templated transcription, negative regulation of cell migration, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of dendritic spine development, positive regulation of dendritic spine maintenance, positive regulation of filopodium assembly, positive regulation of transcription elongation by RNA polymerase II, protein localization to chromatin, regulation of DNA-templated transcription, regulation of postsynaptic density protein 95 clustering; MF: DNA-binding transcription factor binding, histone H3K14ac reader activity, histone H3K4me1 reader activity, metal ion binding, protein binding, protein domain specific binding, transcription corepressor activity, zinc ion binding; CC: chromatin, chromosome, cytoplasm, dendritic shaft, dendritic spine, nucleolus, nucleoplasm, nucleus, site of DNA damage
Pathways:
UniProt: Q9ULU4
Entrez ID: 23613
|
Does Activation of OSTM1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
OSTM1
|
response to virus
|
Hepatoma Cell Line
|
Gene: OSTM1 (osteoclastogenesis associated transmembrane protein 1)
Type: protein-coding
Summary: This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: osteoclast differentiation, transepithelial chloride transport; CC: chloride channel complex, cytosol, lysosomal membrane, lysosome, membrane
Pathways: Autosomal recessive Osteopetrosis pathways, Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q86WC4
Entrez ID: 28962
|
Does Knockout of IRX4 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
IRX4
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: IRX4 (iroquois homeobox 4)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within heart development. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell development, establishment of animal organ orientation, heart development, negative regulation of transcription by RNA polymerase II, neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding; CC: chromatin, nucleus
Pathways: Cardiac Progenitor Differentiation, Heart Development
UniProt: P78413
Entrez ID: 50805
|
Does Knockout of ZFP69B in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
ZFP69B
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: ZFP69B (ZFP69 zinc finger protein B)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Golgi organization. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Golgi organization, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nuclear lumen, nucleolus, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9UJL9
Entrez ID: 65243
|
Does Knockout of PLEKHF2 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
PLEKHF2
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: PLEKHF2 (pleckstrin homology and FYVE domain containing 2)
Type: protein-coding
Summary: Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in protein transport. Located in transport vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endosome organization, endosome to lysosome transport, protein transport; MF: metal ion binding, phosphatidylinositol binding, protein binding, zinc ion binding; CC: cytoplasmic vesicle, early endosome, early endosome membrane, endomembrane system, endoplasmic reticulum, endosome, membrane, transport vesicle
Pathways:
UniProt: Q9H8W4
Entrez ID: 79666
|
Does Knockout of KIF21A in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
KIF21A
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: KIF21A (kinesin family member 21A)
Type: protein-coding
Summary: This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010].
Gene Ontology: BP: anterograde axonal transport, cortical microtubule organization, microtubule-based movement, regulation of axon guidance, regulation of microtubule depolymerization, regulation of microtubule polymerization; MF: ATP binding, ATP hydrolysis activity, ankyrin repeat binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein binding; CC: axon, axon cytoplasm, axonal growth cone, cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, dendrite, growth cone, kinesin complex, microtubule, presynapse
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q7Z4S6
Entrez ID: 55605
|
Does Knockout of ITGB5 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
ITGB5
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ITGB5 (integrin subunit beta 5)
Type: protein-coding
Summary: This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: cell adhesion, cell adhesion mediated by integrin, cell migration, cell-cell adhesion, cell-matrix adhesion, endodermal cell differentiation, epithelial cell-cell adhesion, formation of primary germ layer, integrin-mediated signaling pathway, stress fiber assembly, symbiont entry into host cell, transforming growth factor beta receptor signaling pathway, wound healing, spreading of epidermal cells; MF: integrin binding, metal ion binding, protein binding, signaling receptor binding, virus receptor activity; CC: cell surface, extracellular exosome, focal adhesion, integrin alphav-beta5 complex, integrin complex, membrane, phagocytic vesicle, plasma membrane, receptor complex
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Beta5 beta6 beta7 and beta8 integrin cell surface interactions, Class I MHC mediated antigen processing & presentation, Cross-presentation of particulate exogenous antigens (phagosomes), Dilated cardiomyopathy - Homo sapiens (human), ECM proteoglycans, ECM-receptor interaction - Homo sapiens (human), Elastic fibre formation, Extracellular matrix organization, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Human papillomavirus infection - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Immune System, Integrin cell surface interactions, Integrin-mediated Cell Adhesion, Leptin, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Molecules associated with elastic fibres, Muscle contraction, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Phagosome - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of nuclear SMAD2/3 signaling, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling events mediated by focal adhesion kinase, Smooth Muscle Contraction, Syndecan interactions, TGF-beta receptor signaling activates SMADs, Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling, VEGFA-VEGFR2 Signaling Pathway, miRNA targets in ECM and membrane receptors
UniProt: P18084
Entrez ID: 3693
|
Does Knockout of POTEG in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
POTEG
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: POTEG (POTE ankyrin domain family member G)
Type: protein-coding
Summary: POTE ankyrin domain family member G
Gene Ontology:
Pathways:
UniProt: Q6S5H5
Entrez ID: 404785
|
Does Knockout of TTYH1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
TTYH1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: TTYH1 (tweety family member 1)
Type: protein-coding
Summary: This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: L-glutamate transmembrane transport, Notch signaling pathway, cell adhesion, cell morphogenesis, cell-cell adhesion, cell-substrate adhesion, chloride transmembrane transport, chloride transport, filopodium assembly, gene expression, iron ion transmembrane transport, iron ion transport, mitotic cell cycle, monoatomic ion transmembrane transport, monoatomic ion transport, neurogenesis, stem cell differentiation, stem cell proliferation; MF: calcium ion binding, chloride channel activity, intracellularly calcium-gated chloride channel activity, iron ion transmembrane transporter activity, protein binding, volume-sensitive anion channel activity, volume-sensitive chloride channel activity; CC: chloride channel complex, filopodium membrane, filopodium tip, membrane, plasma membrane, smooth endoplasmic reticulum membrane, synapse
Pathways: Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q9H313
Entrez ID: 57348
|
Does Knockout of NRM in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
NRM
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NRM (nurim)
Type: protein-coding
Summary: The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. This protein shares homology with isoprenylcysteine carboxymethyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012].
Gene Ontology: CC: membrane, nuclear envelope, nuclear inner membrane, nuclear membrane, nucleus
Pathways:
UniProt: Q8IXM6
Entrez ID: 11270
|
Does Knockout of POLR2A in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
POLR2A
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: POLR2A (RNA polymerase II subunit A)
Type: protein-coding
Summary: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, DNA-templated transcription termination, RNA-templated transcription, mRNA transcription by RNA polymerase II, positive regulation of RNA splicing, positive regulation of gene expression, regulation of DNA-templated transcription, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, RNA binding, RNA-directed RNA polymerase activity, hydrolase activity, kinase binding, magnesium ion binding, metal ion binding, microfibril binding, nucleic acid binding, nucleotidyltransferase activity, promoter-specific chromatin binding, protein binding, transferase activity, ubiquitin protein ligase binding, zinc ion binding; CC: DNA-directed RNA polymerase complex, Prp19 complex, RNA polymerase II, core complex, chromosome, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: 22q11.2 copy number variation syndrome, Abortive elongation of HIV-1 transcript in the absence of Tat, Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Cell Cycle, Chromosome Maintenance, DNA Repair, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dual incision in TC-NER, ESR-mediated signaling, Estrogen-dependent gene expression, Eukaryotic Transcription Initiation, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene Silencing by RNA, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, HIV elongation arrest and recovery, Huntington disease - Homo sapiens (human), Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inhibition of DNA recombination at telomere, Late Phase of HIV Life Cycle, Metabolism of RNA, MicroRNA (miRNA) biogenesis, Nucleotide Excision Repair, PIWI-interacting RNA (piRNA) biogenesis, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, Processing of Capped Intron-Containing Pre-mRNA, Pyrimidine metabolism, RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase - Homo sapiens (human), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Telomere Maintenance, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by small RNAs, Viral Infection Pathways, Viral Messenger RNA Synthesis, carm1 and regulation of the estrogen receptor, chromatin remodeling by hswi/snf atp-dependent complexes, mRNA Capping, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, repression of pain sensation by the transcriptional regulator dream, telomeres telomerase cellular aging and immortality, the information processing pathway at the ifn beta enhancer
UniProt: P24928
Entrez ID: 5430
|
Does Activation of ARHGAP11B in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
ARHGAP11B
|
protein/peptide accumulation
|
T cell
|
Gene: ARHGAP11B (Rho GTPase activating protein 11B)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Involved in cerebral cortex development and negative regulation of mitochondrial membrane permeability. Acts upstream of with a positive effect on glutamine catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: L-glutamine catabolic process, cerebral cortex development, negative regulation of mitochondrial membrane permeability, positive regulation of GTPase activity, regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity, protein binding; CC: cytosol, mitochondrial matrix, mitochondrion
Pathways: 15q13.3 copy number variation syndrome, CDC42 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q3KRB8
Entrez ID: 89839
|
Does Knockout of SPRTN in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
SPRTN
|
cell proliferation
|
Bladder Carcinoma
|
Gene: SPRTN (SprT-like N-terminal domain)
Type: protein-coding
Summary: The protein encoded by this gene may play a role in DNA repair during replication of damaged DNA. This protein recruits valosin containing protein (p97) to stalled DNA replication forks where it may prevent excessive translesional DNA synthesis and limit the number of DNA-damage induced mutations. It may also be involved in replication-related G2/M-checkpoint regulation. Deficiency of a similar protein in mouse causes chromosomal instability and progeroid phenotypes. Mutations in this gene have been associated with Ruijs-Aalfs syndrome (RJALS). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: DNA damage response, DNA repair, interstrand cross-link repair, positive regulation of protein ubiquitination, protein autoprocessing, protein-DNA covalent cross-linking repair, proteolysis, response to UV, translesion synthesis; MF: DNA binding, K63-linked polyubiquitin modification-dependent protein binding, double-stranded DNA binding, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, polyubiquitin modification-dependent protein binding, protein binding, single-stranded DNA binding, ubiquitin binding, zinc ion binding; CC: chromatin, chromosome, nuclear speck, nucleoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Repair, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9H040
Entrez ID: 83932
|
Does Knockout of IKZF5 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
IKZF5
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: IKZF5 (IKAROS family zinc finger 5)
Type: protein-coding
Summary: Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002].
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin binding, metal ion binding, protein binding, protein domain specific binding, zinc ion binding; CC: nucleus, protein-containing complex
Pathways:
UniProt: Q9H5V7
Entrez ID: 64376
|
Does Knockout of UBE2I in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
UBE2I
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: UBE2I (ubiquitin conjugating enzyme E2 I)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell division, chromosome segregation, mitotic nuclear membrane reassembly, modulation of chemical synaptic transmission, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, nuclear export, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, protein modification process, protein sumoylation, ubiquitin-dependent protein catabolic process; MF: ATP binding, HLH domain binding, RING-like zinc finger domain binding, RNA binding, SUMO conjugating enzyme activity, SUMO transferase activity, enzyme binding, nucleotide binding, protein binding, small protein activating enzyme binding, transcription coregulator binding, transcription factor binding, transferase activity; CC: PML body, SUMO ligase complex, Schaffer collateral - CA1 synapse, cytoplasm, cytosol, glutamatergic synapse, nuclear body, nuclear envelope, nuclear pore, nucleoplasm, nucleus, perinuclear region of cytoplasm, postsynaptic cytosol, presynaptic cytosol, synaptonemal complex, transferase complex
Pathways: Androgen receptor signaling pathway, AndrogenReceptor, Antiviral mechanism by IFN-stimulated genes, C-MYB transcription factor network, Cell Cycle, Cell Cycle, Mitotic, Coregulation of Androgen receptor activity, Cytokine Signaling in Immune system, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Developmental Biology, Disease, Epigenetic regulation of gene expression, Formation of Incision Complex in GG-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Immune System, Infectious disease, Interferon Signaling, Late SARS-CoV-2 Infection Events, M Phase, MITF-M-regulated melanocyte development, Maturation of nucleoprotein, Meiosis, Meiotic synapsis, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, MicroRNAs in cancer - Homo sapiens (human), Mitotic Anaphase, Mitotic Metaphase and Anaphase, NF-kappa B signaling pathway - Homo sapiens (human), Negative regulation of activity of TFAP2 (AP-2) family transcription factors, Nuclear Envelope (NE) Reassembly, Nucleotide Excision Repair, PKR-mediated signaling, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing and activation of SUMO, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, RNA transport - Homo sapiens (human), Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of cytoplasmic and nuclear SMAD2/3 signaling, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins, Reproduction, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 targets host intracellular signalling and regulatory pathways, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SUMO E3 ligases SUMOylate target proteins, SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA methylation proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of immune response proteins, SUMOylation of intracellular receptors, SUMOylation of nuclear envelope proteins, SUMOylation of transcription cofactors, SUMOylation of transcription factors, SUMOylation of ubiquitinylation proteins, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TGF-beta Signaling Pathway, TGF_beta_Receptor, TNFalpha, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Translation of Structural Proteins, Ubiquitin mediated proteolysis - Homo sapiens (human), Viral Infection Pathways, Vitamin D (calciferol) metabolism, basic mechanisms of sumoylation, er associated degradation (erad) pathway, regulation of transcriptional activity by pml
UniProt: P63279
Entrez ID: 7329
|
Does Knockout of NAF1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
NAF1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: NAF1 (nuclear assembly factor 1 ribonucleoprotein)
Type: protein-coding
Summary: Enables identical protein binding activity and telomerase RNA binding activity. Involved in regulation of nucleobase-containing compound metabolic process; ribosome biogenesis; and telomerase holoenzyme complex assembly. Located in nucleoplasm. Part of sno(s)RNA-containing ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA stabilization, box H/ACA snoRNP assembly, positive regulation of telomere maintenance via telomerase, positive regulation of telomere maintenance via telomere lengthening, protein-RNA complex assembly, pseudouridine synthesis, rRNA processing, ribosome biogenesis, snoRNA guided rRNA pseudouridine synthesis, telomerase RNA localization to Cajal body, telomerase RNA stabilization, telomerase holoenzyme complex assembly; MF: RNA binding, identical protein binding, protein binding, telomerase RNA binding; CC: cytoplasm, nucleoplasm, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex
Pathways:
UniProt: Q96HR8
Entrez ID: 92345
|
Does Knockout of ZSWIM7 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
ZSWIM7
|
cell proliferation
|
Bladder Carcinoma
|
Gene: ZSWIM7 (zinc finger SWIM-type containing 7)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Involved in double-strand break repair via homologous recombination and protein stabilization. Part of Shu complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, double-strand break repair via homologous recombination, protein stabilization; MF: metal ion binding, protein binding, zinc ion binding; CC: Shu complex, nucleus
Pathways:
UniProt: Q19AV6
Entrez ID: 125150
|
Does Knockout of UTP15 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
UTP15
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: UTP15 (UTP15 small subunit processome component)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in endoplasmic reticulum and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding; CC: cytoplasm, endoplasmic reticulum, fibrillar center, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8TED0
Entrez ID: 84135
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.