prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of PLAC1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
PLAC1
|
cell proliferation
|
Cancer Cell Line
|
Gene: PLAC1 (placenta enriched 1)
Type: protein-coding
Summary: Involved in placenta development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: placenta development
Pathways:
UniProt: Q9HBJ0
Entrez ID: 10761
|
Does Knockout of GOLGA6A in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
GOLGA6A
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GOLGA6A (golgin A6 family member A)
Type: protein-coding
Summary: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The protein encoded by this gene is a member of the golgin family of proteins, whose members localize to the Golgi. This gene is found in a large, low copy repeat sequence or duplicon that is found in multiple copies, that are greather than 90% similar, on chromosome 15. Duplicons are associated with deletions, inversions and other chromosome rearrangements that underlie genomic disease. The protein encoded by this gene is thought to be a functional golgin protein while the majority of the related copies of this gene are thought to be transcribed pseudogenes. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: Golgi apparatus, Golgi cis cisterna, Golgi cisterna membrane, cis-Golgi network
Pathways:
UniProt: Q9NYA3
Entrez ID: 342096
|
Does Knockout of HDAC9 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
HDAC9
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: HDAC9 (histone deacetylase 9)
Type: protein-coding
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell activation, B cell differentiation, cellular response to insulin stimulus, cholesterol homeostasis, chromatin organization, epigenetic regulation of gene expression, heart development, inflammatory response, negative regulation of DNA-templated transcription, negative regulation of cytokine production, negative regulation of gene expression, epigenetic, negative regulation of macromolecule biosynthetic process, negative regulation of transcription by RNA polymerase II, positive regulation of cell migration involved in sprouting angiogenesis, regulation of skeletal muscle fiber development, regulation of striated muscle cell differentiation; MF: DNA-binding transcription factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, histone H3K14 deacetylase activity, hydrolytic mechanism, histone H3K9 deacetylase activity, hydrolytic mechanism, histone H4K16 deacetylase activity, hydrolytic mechanism, histone deacetylase activity, histone deacetylase activity, hydrolytic mechanism, histone deacetylase binding, hydrolase activity, metal ion binding, protein binding, protein kinase C binding, protein lysine deacetylase activity, transcription corepressor activity; CC: cytoplasm, histone deacetylase complex, histone methyltransferase complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Alcoholism - Homo sapiens (human), Cardiac Hypertrophic Response, Ethanol effects on histone modifications, Initiation of transcription and translation elongation at the HIV-1 LTR, MicroRNAs in cardiomyocyte hypertrophy, Neural Crest Differentiation, Neutrophil extracellular trap formation - Homo sapiens (human), Signaling events mediated by HDAC Class II, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, VEGFA-VEGFR2 Signaling Pathway, Viral carcinogenesis - Homo sapiens (human), nfat and hypertrophy of the heart , signal dependent regulation of myogenesis by corepressor mitr, sumoylation by ranbp2 regulates transcriptional repression
UniProt: Q9UKV0
Entrez ID: 9734
|
Does Knockout of SRP19 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
SRP19
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: SRP19 (signal recognition particle 19)
Type: protein-coding
Summary: Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, cotranslational protein targeting to membrane; MF: 7S RNA binding, RNA binding, protein binding, ribosome binding; CC: cytoplasm, cytosol, nuclear body, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Homo sapiens (human), SRP-dependent cotranslational protein targeting to membrane, Translation
UniProt: P09132
Entrez ID: 6728
|
Does Knockout of CHAF1B in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
CHAF1B
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: CHAF1B (chromatin assembly factor 1 subunit B)
Type: protein-coding
Summary: Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin assembly, chromatin organization, nucleosome assembly; MF: chromatin binding, histone binding, protein binding, unfolded protein binding; CC: CAF-1 complex, chromatin, cytoplasm, cytosol, nucleoplasm, nucleus, protein-containing complex
Pathways: btg family proteins and cell cycle regulation
UniProt: Q13112
Entrez ID: 8208
|
Does Knockout of EIF3I in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
EIF3I
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: EIF3I (eukaryotic translation initiation factor 3 subunit I)
Type: protein-coding
Summary: Contributes to translation initiation factor activity. Involved in translational initiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation; MF: RNA binding, protein binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, extracellular exosome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, TGF_beta_Receptor, Translation, Translation Factors, Translation initiation complex formation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: Q13347
Entrez ID: 8668
|
Does Knockout of GRIA3 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
GRIA3
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: GRIA3 (glutamate ionotropic receptor AMPA type subunit 3)
Type: protein-coding
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium-mediated signaling, glutamate receptor signaling pathway, ionotropic glutamate receptor signaling pathway, long-term synaptic potentiation, modulation of chemical synaptic transmission, monoatomic ion transmembrane transport, monoatomic ion transport, protein heterotetramerization, protein homotetramerization, regulation of postsynaptic membrane potential, regulation of presynaptic membrane potential, synaptic transmission, glutamatergic; MF: AMPA glutamate receptor activity, amyloid-beta binding, glutamate-gated calcium ion channel activity, glutamate-gated receptor activity, ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, monoatomic ion channel activity, signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: AMPA glutamate receptor complex, dendritic spine, endocytic vesicle membrane, membrane, parallel fiber to Purkinje cell synapse, plasma membrane, postsynaptic density membrane, postsynaptic membrane, synapse
Pathways: Activation of AMPA receptors, Activation of NMDA receptors and postsynaptic events, Amphetamine addiction - Homo sapiens (human), Brain-derived neurotrophic factor (BDNF) signaling pathway, Circadian entrainment - Homo sapiens (human), Common Pathways Underlying Drug Addiction, Dopaminergic synapse - Homo sapiens (human), Glutamate binding, activation of AMPA receptors and synaptic plasticity, Glutamatergic synapse - Homo sapiens (human), Huntington disease - Homo sapiens (human), Long-term depression - Homo sapiens (human), MECP2 and Associated Rett Syndrome, Neuroactive ligand-receptor interaction - Homo sapiens (human), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine addiction - Homo sapiens (human), PKC-gamma calcium signaling pathway in ataxia, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Protein-protein interactions at synapses, Retrograde endocannabinoid signaling - Homo sapiens (human), Spinocerebellar ataxia - Homo sapiens (human), Synaptic adhesion-like molecules, Trafficking of AMPA receptors, Trafficking of GluR2-containing AMPA receptors, Transcriptional misregulation in cancer - Homo sapiens (human), Transmission across Chemical Synapses, Unblocking of NMDA receptors, glutamate binding and activation, cAMP signaling pathway - Homo sapiens (human)
UniProt: P42263
Entrez ID: 2892
|
Does Knockout of ATP6V1H in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
ATP6V1H
|
cell proliferation
|
Bladder Carcinoma
|
Gene: ATP6V1H (ATPase H+ transporting V1 subunit H)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: Golgi lumen acidification, endocytosis, endosomal lumen acidification, intracellular pH reduction, lysosomal lumen acidification, monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, vacuolar acidification; MF: ATP hydrolysis activity, enzyme regulator activity, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: Golgi membrane, clathrin-coated vesicle membrane, cytoplasmic vesicle, cytosol, endosome membrane, extracellular exosome, extrinsic component of synaptic vesicle membrane, lysosomal membrane, membrane, plasma membrane, proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Bacterial Infection Pathways, Blockage of phagosome acidification, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Developmental Biology, Disease, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), HIV Infection, Host Interactions of HIV factors, Human papillomavirus infection - Homo sapiens (human), Immune System, Infection with Mycobacterium tuberculosis, Infectious disease, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Homo sapiens (human), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Nef Mediated CD4 Down-regulation, Nef Mediated CD8 Down-regulation, Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Response of Mtb to phagocytosis, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Suppression of phagosomal maturation, Synaptic vesicle cycle - Homo sapiens (human), The role of Nef in HIV-1 replication and disease pathogenesis, Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Homo sapiens (human), Vibrio cholerae infection - Homo sapiens (human), Viral Infection Pathways, adenosine ribonucleotides <i>de novo</i> biosynthesis, mTOR signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: Q9UI12
Entrez ID: 51606
|
Does Knockout of ZBTB45 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
ZBTB45
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ZBTB45 (zinc finger and BTB domain containing 45)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, nervous system development, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q96K62
Entrez ID: 84878
|
Does Knockout of NXF2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
NXF2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: NXF2 (nuclear RNA export factor 2)
Type: protein-coding
Summary: This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: RNA transport, mRNA export from nucleus, mRNA transport, poly(A)+ mRNA export from nucleus; MF: RNA binding, nucleic acid binding, protein binding; CC: cytoplasm, cytosol, nuclear RNA export factor complex, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Influenza A - Homo sapiens (human), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9GZY0
Entrez ID: 56001
|
Does Knockout of LYNX1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
LYNX1
|
cell proliferation
|
Cancer Cell Line
|
Gene: LYNX1 (Ly6/neurotoxin 1)
Type: protein-coding
Summary: This gene encodes a GPI-anchored, cell membrane bound member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This protein interacts with nicotinic acetylcholine receptors (nAChRs), and is thought to function as a modulator of nAChR activity to prevent excessive excitation. Alternatively spliced transcript variants have been found for this gene. Read-through transcription between this gene and the neighboring downstream gene (SLURP2) generates naturally-occurring transcripts (LYNX1-SLURP2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Sep 2017].
Gene Ontology: BP: acetylcholine receptor signaling pathway, regulation of neurotransmitter receptor activity, synaptic transmission, cholinergic; MF: acetylcholine receptor binding, acetylcholine receptor inhibitor activity, acetylcholine receptor regulator activity, ion channel inhibitor activity, protein binding; CC: cell projection, dendrite, endoplasmic reticulum, membrane, plasma membrane, side of membrane, synapse
Pathways:
UniProt: P0DP58
Entrez ID: 66004
|
Does Knockout of MAEL in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
MAEL
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: MAEL (maelstrom spermatogenic transposon silencer)
Type: protein-coding
Summary: Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in gamete generation; negative regulation of macromolecule metabolic process; and piRNA metabolic process. Predicted to act upstream of or within several processes, including homologous chromosome pairing at meiosis; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of macromolecule metabolic process. Predicted to be located in piP-body. Predicted to be active in P granule and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, apoptotic process, cell differentiation, cell morphogenesis, ectopic germ cell programmed cell death, fertilization, gene expression, homologous chromosome pairing at meiosis, intrinsic apoptotic signaling pathway in response to DNA damage, male meiotic nuclear division, meiotic cell cycle, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of developmental process, negative regulation of gene expression, negative regulation of reproductive process, negative regulation of transcription by RNA polymerase II, piRNA processing, regulation of miRNA-mediated gene silencing, regulation of organ growth, regulatory ncRNA-mediated gene silencing, spermatogenesis, transposable element silencing by piRNA-mediated DNA methylation; MF: DNA binding, sequence-specific DNA binding; CC: P granule, XY body, autosome, chromatin, chromatoid body, cytoplasm, male germ cell nucleus, nucleus, perinuclear region of cytoplasm, piP-body
Pathways: Gene Silencing by RNA, Gene expression (Transcription), PIWI-interacting RNA (piRNA) biogenesis
UniProt: Q96JY0
Entrez ID: 84944
|
Does Knockout of SPRY2 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
SPRY2
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: SPRY2 (sprouty RTK signaling antagonist 2)
Type: protein-coding
Summary: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ERK1 and ERK2 cascade, animal organ development, branching morphogenesis of an epithelial tube, bud elongation involved in lung branching, cell fate commitment, cellular response to leukemia inhibitory factor, cellular response to vascular endothelial growth factor stimulus, establishment of mitotic spindle orientation, fibroblast growth factor receptor signaling pathway, inner ear morphogenesis, lung development, lung growth, lung morphogenesis, negative regulation of ERK1 and ERK2 cascade, negative regulation of Ras protein signal transduction, negative regulation of angiogenesis, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of cell projection organization, negative regulation of epithelial to mesenchymal transition, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of lens fiber cell differentiation, negative regulation of neurotrophin TRK receptor signaling pathway, negative regulation of protein ubiquitination, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of vascular endothelial growth factor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of cell migration, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of gene expression, positive regulation of peptidyl-serine phosphorylation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of signal transduction, respiratory system development, sensory perception of sound; MF: molecular function inhibitor activity, protein binding, protein kinase binding, protein serine/threonine kinase activator activity, protein serine/threonine kinase inhibitor activity, ubiquitin-protein transferase inhibitor activity; CC: actin cytoskeleton, cell projection, cytoplasm, cytoskeleton, cytosol, membrane, microtubule, microtubule cytoskeleton, microtubule end, nucleus, plasma membrane, ruffle membrane
Pathways: EGF-EGFR signaling pathway, EGFR downregulation, EGFR1, Ectoderm Differentiation, FGF signaling pathway, Glioblastoma signaling pathways, Internalization of ErbB1, MicroRNAs in cancer - Homo sapiens (human), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Signal Transduction, Signaling by EGFR, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Receptor Tyrosine Kinases, Signaling events mediated by PTP1B, Spry regulation of FGF signaling, sprouty regulation of tyrosine kinase signals
UniProt: O43597
Entrez ID: 10253
|
Does Knockout of MBL2 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
MBL2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: MBL2 (mannose binding lectin 2)
Type: protein-coding
Summary: This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020].
Gene Ontology: BP: activation of membrane attack complex, acute-phase response, antiviral innate immune response, cell surface pattern recognition receptor signaling pathway, complement activation, complement activation, classical pathway, complement activation, lectin pathway, defense response to Gram-positive bacterium, defense response to bacterium, immune system process, innate immune response, killing by host of symbiont cells, killing of cells of another organism, negative regulation of viral process, opsonization, positive regulation of opsonization, positive regulation of phagocytosis, protein maturation, proteolysis, response to oxidative stress, surfactant homeostasis, zymogen activation; MF: D-mannose binding, calcium-dependent protein binding, carbohydrate binding, identical protein binding, pattern recognition receptor activity, protein binding, signaling receptor binding; CC: cell surface, collagen trimer, external side of plasma membrane, extracellular region, extracellular space, multivesicular body, serine-type endopeptidase complex, symbiont cell surface
Pathways: Complement and coagulation cascades - Homo sapiens (human), Complement system, Coronavirus disease - COVID-19 - Homo sapiens (human), Ebola Virus Pathway on Host, Phagosome - Homo sapiens (human), Regulation of toll-like receptor signaling pathway, Staphylococcus aureus infection - Homo sapiens (human), lectin induced complement pathway
UniProt: P11226
Entrez ID: 4153
|
Does Knockout of CLDN16 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
CLDN16
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CLDN16 (claudin 16)
Type: protein-coding
Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: bicellular tight junction assembly, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion, intercellular transport, intracellular monoatomic cation homeostasis, magnesium ion transmembrane transport, metal ion transport, monoatomic ion transport, paracellular transport, renal absorption; MF: PDZ domain binding, identical protein binding, magnesium ion transmembrane transporter activity, paracellular tight junction channel activity, protein binding, structural molecule activity; CC: anchoring junction, bicellular tight junction, membrane, plasma membrane, tight junction
Pathways: Cell adhesion molecules - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Epithelial to mesenchymal transition in colorectal cancer, Hepatitis C - Homo sapiens (human), Leukocyte transendothelial migration - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Tight junction - Homo sapiens (human), Tight junction interactions
UniProt: Q9Y5I7
Entrez ID: 10686
|
Does Knockout of PXT1 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
PXT1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: PXT1 (peroxisomal testis enriched protein 1)
Type: protein-coding
Summary: Predicted to be involved in positive regulation of apoptotic process. Predicted to act upstream of or within spermatogenesis. Predicted to be active in nucleus and peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: peroxisome
Pathways:
UniProt: Q8NFP0
Entrez ID: 222659
|
Does Knockout of NREP in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
NREP
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: NREP (neuronal regeneration related protein)
Type: protein-coding
Summary: Predicted to be involved in axon regeneration; regulation of neuron differentiation; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: axon regeneration, regulation of neuron differentiation, regulation of transforming growth factor beta receptor signaling pathway
Pathways: MECP2 and Associated Rett Syndrome
UniProt: Q16612
Entrez ID: 9315
|
Does Knockout of TNS2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
TNS2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: TNS2 (tensin 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular homeostasis, collagen metabolic process, kidney development, multicellular organism growth, multicellular organismal-level homeostasis, negative regulation of cell population proliferation, negative regulation of insulin receptor signaling pathway, peptidyl-tyrosine dephosphorylation, response to muscle activity; MF: hydrolase activity, identical protein binding, kinase binding, lipid binding, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein tyrosine phosphatase activity, zinc ion binding; CC: anchoring junction, cytoplasm, focal adhesion, membrane, plasma membrane
Pathways: EGFR1
UniProt: Q63HR2
Entrez ID: 23371
|
Does Knockout of AHCY in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
AHCY
|
cell proliferation
|
Melanoma Cell Line
|
Gene: AHCY (adenosylhomocysteinase)
Type: protein-coding
Summary: S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: S-adenosylmethionine cycle, one-carbon metabolic process; MF: adenosylhomocysteinase activity, hydrolase activity, protein binding; CC: cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, melanosome, nucleus
Pathways: Betaine Metabolism, Biological oxidations, Cystathionine Beta-Synthase Deficiency, Cysteine and methionine metabolism - Homo sapiens (human), Defective AHCY causes HMAHCHD, Disease, Diseases of metabolism, Ethanol effects on histone modifications, Folate Metabolism, Glycine N-methyltransferase Deficiency, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, Metabolic disorders of biological oxidation enzymes, Metabolism, Metabolism of amino acids and derivatives, Metabolism of ingested SeMet, Sec, MeSec into H2Se, Methionine Adenosyltransferase Deficiency, Methionine De Novo and Salvage Pathway, Methionine Metabolism, Methylation, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), One-carbon metabolism, Phase II - Conjugation of compounds, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, Selenoamino Acid Metabolism, Selenoamino acid metabolism, Sulfur amino acid metabolism, TCR, Trans-sulfuration and one-carbon metabolism, Trans-sulfuration pathway, cysteine biosynthesis, methionine degradation, superpathway of methionine degradation
UniProt: P23526
Entrez ID: 191
|
Does Knockout of SIGLEC11 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
SIGLEC11
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: SIGLEC11 (sialic acid binding Ig like lectin 11)
Type: protein-coding
Summary: This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: cell adhesion; MF: carbohydrate binding, phosphatase binding, sialic acid binding; CC: membrane, plasma membrane
Pathways: Adaptive Immune System, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
UniProt: Q96RL6
Entrez ID: 114132
|
Does Knockout of SYK in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
SYK
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: SYK (spleen associated tyrosine kinase)
Type: protein-coding
Summary: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: B cell differentiation, B cell receptor signaling pathway, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, TORC1 signaling, adaptive immune response, amyloid-beta clearance, angiogenesis, animal organ morphogenesis, apoptotic signaling pathway, autophagosome assembly, beta selection, blood vessel morphogenesis, calcium-mediated signaling, cell activation, cell surface pattern recognition receptor signaling pathway, cell surface receptor signaling pathway, cellular response to amyloid-beta, cellular response to lectin, cellular response to lipid, cellular response to low-density lipoprotein particle stimulus, cellular response to molecule of fungal origin, cellular response to nutrient levels, collagen-activated tyrosine kinase receptor signaling pathway, defense response to bacterium, enzyme-linked receptor protein signaling pathway, establishment of localization in cell, gamma-delta T cell differentiation, immune system process, innate immune response, integrin-mediated signaling pathway, interleukin-3-mediated signaling pathway, intracellular signal transduction, leukocyte activation involved in immune response, leukocyte cell-cell adhesion, leukocyte migration, leukotriene biosynthetic process, lymph vessel development, macrophage activation involved in immune response, mast cell degranulation, negative regulation of TORC1 signaling, negative regulation of autophagy, negative regulation of inflammatory response to antigenic stimulus, neutrophil activation involved in immune response, neutrophil chemotaxis, peptidyl-tyrosine phosphorylation, platelet activation, positive regulation of B cell differentiation, positive regulation of MAPK cascade, positive regulation of TORC1 signaling, positive regulation of alpha-beta T cell differentiation, positive regulation of alpha-beta T cell proliferation, positive regulation of autophagy, positive regulation of bone resorption, positive regulation of calcium-mediated signaling, positive regulation of cell adhesion mediated by integrin, positive regulation of cold-induced thermogenesis, positive regulation of cytokine production, positive regulation of gamma-delta T cell differentiation, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of interleukin-10 production, positive regulation of interleukin-12 production, positive regulation of interleukin-3 production, positive regulation of interleukin-4 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of lymphocyte differentiation, positive regulation of mast cell cytokine production, positive regulation of mast cell degranulation, positive regulation of monocyte chemotactic protein-1 production, positive regulation of protein-containing complex assembly, positive regulation of receptor internalization, positive regulation of superoxide anion generation, positive regulation of tumor necrosis factor production, positive regulation of type I interferon production, protein import into nucleus, protein phosphorylation, receptor internalization, regulation of DNA-binding transcription factor activity, regulation of ERK1 and ERK2 cascade, regulation of arachidonate secretion, regulation of immune response, regulation of neutrophil degranulation, regulation of phagocytosis, regulation of platelet activation, regulation of platelet aggregation, regulation of superoxide anion generation, regulation of tumor necrosis factor-mediated signaling pathway, serotonin secretion, serotonin secretion by platelet, stimulatory C-type lectin receptor signaling pathway; MF: ATP binding, SH2 domain binding, Toll-like receptor binding, integrin binding, interleukin-15 receptor binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, phosphatase binding, phospholipase binding, phosphotyrosine residue binding, protein binding, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, protein tyrosine kinase activity, scaffold protein binding, signaling receptor binding, transferase activity; CC: B cell receptor complex, T cell receptor complex, cytoplasm, cytosol, early phagosome, membrane, nucleus, plasma membrane, protein-containing complex
Pathways: Alpha-synuclein signaling, Atypical NF-kappaB pathway, B Cell Receptor Signaling Pathway, B cell receptor signaling pathway - Homo sapiens (human), BCR, BCR signaling pathway, C-type lectin receptor signaling pathway - Homo sapiens (human), Class I PI3K signaling events, Coronavirus disease - COVID-19 - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), FAS (CD95) signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fc-epsilon receptor I signaling in mast cells, Fibrin Complement Receptor 3 Signaling Pathway, GMCSF-mediated signaling events, Herpes simplex virus 1 infection - Homo sapiens (human), IL-2 signaling pathway, IL-3 signaling pathway, IL-5 signaling pathway, IL2, IL2-mediated signaling events, IL3, IL4, IL5, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Microglia Pathogen Phagocytosis Pathway, NF-kappa B signaling pathway - Homo sapiens (human), Natural killer cell mediated cytotoxicity - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), Osteoclast differentiation - Homo sapiens (human), Osteopontin-mediated events, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Platelet activation - Homo sapiens (human), RANKL-RANK signaling pathway, Regulation of toll-like receptor signaling pathway, TCR, TNFalpha, Thromboxane A2 receptor signaling, Tuberculosis - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), bcr signaling pathway, fc epsilon receptor i signaling in mast cells, il 2 signaling pathway, ras-independent pathway in nk cell-mediated cytotoxicity
UniProt: P43405
Entrez ID: 6850
|
Does Knockout of NCKAP1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
NCKAP1
|
cell proliferation
|
Cancer Cell Line
|
Gene: NCKAP1 (NCK associated protein 1)
Type: protein-coding
Summary: Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of lamellipodium assembly. Located in extracellular exosome and focal adhesion. Part of SCAR complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Rac protein signal transduction, apical protein localization, apoptotic process, basal protein localization, cell migration, cell migration involved in gastrulation, cell morphogenesis, cell projection assembly, central nervous system development, cortical actin cytoskeleton organization, embryonic body morphogenesis, embryonic foregut morphogenesis, embryonic heart tube development, endoderm development, establishment or maintenance of actin cytoskeleton polarity, in utero embryonic development, lamellipodium assembly, mesodermal cell migration, neural tube closure, neuron projection morphogenesis, notochord development, notochord morphogenesis, paraxial mesoderm development, paraxial mesoderm morphogenesis, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of actin filament polymerization, positive regulation of lamellipodium assembly, protein stabilization, regulation of protein localization, somitogenesis, zygotic determination of anterior/posterior axis, embryo; MF: protein binding, small GTPase binding; CC: SCAR complex, cell projection, cytosol, extracellular exosome, filamentous actin, focal adhesion, lamellipodium, lamellipodium membrane, membrane, plasma membrane, postsynapse, ruffle
Pathways: Disease, E-cadherin signaling in the nascent adherens junction, ErbB1 downstream signaling, Exercise-induced Circadian Regulation, FCGR3A-mediated phagocytosis, Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania phagocytosis, PDGFR-beta signaling pathway, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), RAC1 GTPase cycle, RAC1 signaling pathway, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Stabilization and expansion of the E-cadherin adherens junction, VEGFA-VEGFR2 Pathway, y branching of actin filaments
UniProt: Q9Y2A7
Entrez ID: 10787
|
Does Knockout of RNF223 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
RNF223
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: RNF223 (ring finger protein 223)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: E7ERA6
Entrez ID: 401934
|
Does Knockout of DDX6 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
DDX6
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: DDX6 (DEAD-box helicase 6)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: P-body assembly, miRNA-mediated gene silencing by inhibition of translation, negative regulation of neuron differentiation, negative regulation of translation, neuron differentiation, spermatid differentiation, spermatogenesis, stem cell population maintenance, stress granule assembly, viral RNA genome packaging; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, cadherin binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding, protein domain specific binding; CC: P-body, RISC complex, adherens junction, chromatoid body, concave side of sperm head, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, heterochromatin, membrane, nucleus, outer dense fiber, perinuclear region of cytoplasm, plasma membrane, sperm annulus
Pathways: Deadenylation-dependent mRNA decay, EGFR1, Metabolism of RNA, RNA degradation - Homo sapiens (human), mRNA decay by 5' to 3' exoribonuclease
UniProt: P26196
Entrez ID: 1656
|
Does Knockout of MRPS23 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
MRPS23
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: MRPS23 (mitochondrial ribosomal protein S23)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, nuclear membrane, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q9Y3D9
Entrez ID: 51649
|
Does Knockout of GPT2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
GPT2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GPT2 (glutamic--pyruvic transaminase 2)
Type: protein-coding
Summary: This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: 2-oxoglutarate metabolic process, L-alanine catabolic process, L-alanine metabolic process; MF: L-alanine:2-oxoglutarate aminotransferase activity, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Alanine metabolism, Alanine, aspartate and glutamate metabolism - Homo sapiens (human), Amino Acid Metabolism Pathway Excerpt (Histidine catabolism extension), Amino Acid metabolism, Arginine biosynthesis - Homo sapiens (human), Glucose-Alanine Cycle, Metabolism, Metabolism of amino acids and derivatives, alanine biosynthesis/degradation
UniProt: Q8TD30
Entrez ID: 84706
|
Does Knockout of IMP3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
IMP3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: IMP3 (IMP U3 small nucleolar ribonucleoprotein 3)
Type: protein-coding
Summary: This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: maturation of SSU-rRNA, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding, rRNA binding, snoRNA binding; CC: Mpp10 complex, cytosol, nucleolus, nucleoplasm, nucleus, preribosome, ribonucleoprotein complex, small-subunit processome
Pathways: IL-18 signaling pathway, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NV31
Entrez ID: 55272
|
Does Knockout of NPB in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
NPB
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: NPB (neuropeptide B)
Type: protein-coding
Summary: This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuropeptide B-29, which are characterized by an N-terminal brominated tryptophan amino acid. Both of the encoded peptides bind with higher affinity to neuropeptide B/W (NPB/W) receptor 1 compared to the related NPB/W receptor 2. These peptides may regulate feeding, pain perception, and stress in rodents. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, feeding behavior, neuropeptide signaling pathway; MF: G protein-coupled receptor binding, protein binding; CC: extracellular region
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q8NG41
Entrez ID: 256933
|
Does Knockout of MRPS34 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
MRPS34
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MRPS34 (mitochondrial ribosomal protein S34)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: mitochondrial translation; MF: structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: P82930
Entrez ID: 65993
|
Does Knockout of RHEB in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
RHEB
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: RHEB (Ras homolog, mTORC1 binding)
Type: protein-coding
Summary: This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: TORC1 signaling, autophagosome assembly, cellular response to nutrient levels, cytoplasmic translation, negative regulation of autophagy, negative regulation of cold-induced thermogenesis, negative regulation of translational initiation, oligodendrocyte differentiation, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of oligodendrocyte differentiation, positive regulation of translational initiation, regulation of TOR signaling, regulation of cell cycle, regulation of macroautophagy, regulation of type B pancreatic cell development, response to virus, signal transduction, small GTPase-mediated signal transduction; MF: GDP binding, GTP binding, GTPase activity, hydrolase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activator activity, protein kinase binding, protein serine/threonine kinase activator activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, lysosomal membrane, lysosome, membrane, plasma membrane, postsynaptic density, spliceosomal complex, synapse
Pathways: AMPK signaling pathway - Homo sapiens (human), Angiopoietin Like Protein 8 Regulatory Pathway, Autophagy - animal - Homo sapiens (human), BDNF-TrkB Signaling, Cellular senescence - Homo sapiens (human), Choline metabolism in cancer - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Follicle Stimulating Hormone (FSH) signaling pathway, Fragile X Syndrome, Head and Neck Squamous Cell Carcinoma, Herpes simplex virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Insulin Signaling, Insulin signaling pathway - Homo sapiens (human), Joubert Syndrome, Leucine Stimulation on Insulin Signaling, Longevity regulating pathway - Homo sapiens (human), Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, PI3K-AKT-mTOR signaling pathway and therapeutic opportunities, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in clear cell renal cell carcinoma, Phospholipase D signaling pathway - Homo sapiens (human), Synaptic signaling pathways associated with autism spectrum disorder, Target Of Rapamycin (TOR) Signaling, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, mTOR signaling pathway, mTOR signaling pathway - Homo sapiens (human), mtor signaling pathway
UniProt: Q15382
Entrez ID: 6009
|
Does Knockout of TBC1D28 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
TBC1D28
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TBC1D28 (TBC1 domain family member 28)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q2M2D7
Entrez ID: 254272
|
Does Knockout of AP4E1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
AP4E1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: AP4E1 (adaptor related protein complex 4 subunit epsilon 1)
Type: protein-coding
Summary: This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: establishment of protein localization, intracellular protein localization, intracellular protein transport, protein targeting, protein transport, vesicle-mediated transport; MF: cargo adaptor activity, protein binding; CC: AP-4 adaptor complex, Golgi apparatus, endosome lumen, membrane, membrane coat, trans-Golgi network, trans-Golgi network membrane
Pathways: Golgi Associated Vesicle Biogenesis, Lysosome - Homo sapiens (human), Lysosome Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q9UPM8
Entrez ID: 23431
|
Does Knockout of ORC5 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
ORC5
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: ORC5 (origin recognition complex subunit 5)
Type: protein-coding
Summary: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010].
Gene Ontology: BP: DNA replication, DNA replication initiation, regulation of DNA replication; MF: ATP binding, DNA replication origin binding, nucleotide binding, protein binding; CC: chromatin, chromosome, chromosome, telomeric region, cytosol, nuclear origin of replication recognition complex, nucleoplasm, nucleus, origin recognition complex
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the ORC complex at the origin of replication, Assembly of the pre-replicative complex, CDC6 association with the ORC:origin complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), DNA Replication, DNA Replication Pre-Initiation, E2F mediated regulation of DNA replication, E2F-enabled inhibition of pre-replication complex formation, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, cdk regulation of dna replication
UniProt: O43913
Entrez ID: 5001
|
Does Knockout of RGS7BP in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
RGS7BP
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RGS7BP (regulator of G protein signaling 7 binding protein)
Type: protein-coding
Summary: This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, negative regulation of signal transduction, regulation of postsynaptic membrane potential; CC: axon, cytoplasm, dendritic shaft, dendritic spine head, glutamatergic synapse, membrane, neuron projection, nucleus, perikaryon, plasma membrane, postsynapse, postsynaptic density membrane, presynapse, presynaptic membrane
Pathways:
UniProt: Q6MZT1
Entrez ID: 401190
|
Does Knockout of ZKSCAN7 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
ZKSCAN7
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ZKSCAN7 (zinc finger with KRAB and SCAN domains 7)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q9P0L1
Entrez ID: 55888
|
Does Knockout of RPL38 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
RPL38
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RPL38 (ribosomal protein L38)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 90S preribosome assembly, axial mesoderm development, cytoplasmic translation, middle ear morphogenesis, ossification, protein-RNA complex assembly, regulation of translation, sensory perception of sound, skeletal system development, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, eukaryotic 80S initiation complex, focal adhesion, postsynaptic density, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Mesodermal commitment pathway, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P63173
Entrez ID: 6169
|
Does Knockout of TMC3 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
TMC3
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: TMC3 (transmembrane channel like 3)
Type: protein-coding
Summary: Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q7Z5M5
Entrez ID: 342125
|
Does Knockout of PDE1B in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
PDE1B
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PDE1B (phosphodiesterase 1B)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].
Gene Ontology: BP: cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to macrophage colony-stimulating factor stimulus, dopamine catabolic process, locomotory behavior, monocyte differentiation, negative regulation of cAMP/PKA signal transduction, response to amphetamine, serotonin metabolic process, signal transduction, visual learning; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, calmodulin binding, calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity, calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity, cyclic-nucleotide phosphodiesterase activity, hydrolase activity, metal ion binding, phosphoric diester hydrolase activity, protein binding; CC: cytoplasm, cytosol, neuronal cell body
Pathways: Ca-dependent events, CaM pathway, Calcium signaling pathway - Homo sapiens (human), Calmodulin induced events, Cam-PDE 1 activation, DAG and IP3 signaling, G Protein Signaling Pathways, G alpha (i) signalling events, G alpha (s) signalling events, G-protein mediated events, GPCR downstream signalling, Hemostasis, Intracellular signaling by second messengers, Morphine addiction - Homo sapiens (human), Nitric oxide stimulates guanylate cyclase, Olfactory transduction - Homo sapiens (human), Opioid Signalling, PLC beta mediated events, Phosphodiesterases in neuronal function, Platelet homeostasis, Purine metabolism - Homo sapiens (human), Renin secretion - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Taste transduction - Homo sapiens (human), cGMP effects
UniProt: Q01064
Entrez ID: 5153
|
Does Knockout of WASHC4 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
WASHC4
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: WASHC4 (WASH complex subunit 4)
Type: protein-coding
Summary: This gene encodes a component of the WASH complex, which functions in the intracellular transport of endosomes. Mutations in this gene have been detected in individuals with autosomal recessive cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
Gene Ontology: BP: cognition, endolysosomal toll-like receptor signaling pathway, endosomal transport, endosome organization, neuromuscular process, nuclear envelope budding, protein transport, regulation of Arp2/3 complex-mediated actin nucleation, regulation of protein complex stability; CC: BLOC-1 complex, WASH complex, early endosome, early endosome membrane, endosome, nucleoplasm
Pathways: Endocytosis - Homo sapiens (human)
UniProt: Q2M389
Entrez ID: 23325
|
Does Knockout of RAD1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
RAD1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: RAD1 (RAD1 checkpoint DNA exonuclease)
Type: protein-coding
Summary: This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, cellular response to ionizing radiation, meiotic recombination checkpoint signaling, substantia nigra development; MF: damaged DNA binding, double-stranded DNA 3'-5' DNA exonuclease activity, protein binding; CC: checkpoint clamp complex, chromosome, nucleoplasm, nucleus
Pathways: ATR Signaling, ATR signaling pathway, Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, Cellular senescence - Homo sapiens (human), DNA Double-Strand Break Repair, DNA Repair, DNA damage response, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Fanconi anemia pathway, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Impaired BRCA2 binding to RAD51, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of Telomerase, Transcriptional Regulation by TP53, miRNA regulation of DNA damage response, role of brca1 brca2 and atr in cancer susceptibility
UniProt: O60671
Entrez ID: 5810
|
Does Knockout of TIRAP in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
TIRAP
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TIRAP (TIR domain containing adaptor protein)
Type: protein-coding
Summary: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, MyD88-dependent toll-like receptor signaling pathway, TIRAP-dependent toll-like receptor 4 signaling pathway, cell surface receptor signaling pathway, cellular response to bacterial lipopeptide, cellular response to lipoteichoic acid, defense response to Gram-positive bacterium, immune system process, inflammatory response, innate immune response, myeloid cell differentiation, positive regulation of B cell proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of JNK cascade, positive regulation of canonical NF-kappaB signal transduction, positive regulation of chemokine (C-X-C motif) ligand 1 production, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of interleukin-12 production, positive regulation of interleukin-15 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of neutrophil chemotaxis, positive regulation of protein-containing complex assembly, positive regulation of toll-like receptor 2 signaling pathway, positive regulation of toll-like receptor 3 signaling pathway, positive regulation of toll-like receptor 4 signaling pathway, positive regulation of tumor necrosis factor production, regulation of innate immune response, regulation of interferon-beta production, response to lipopolysaccharide, signal transduction, toll-like receptor 4 signaling pathway; MF: Toll-like receptor 2 binding, Toll-like receptor 4 binding, identical protein binding, molecular adaptor activity, phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein kinase C binding, protein-macromolecule adaptor activity, signaling adaptor activity; CC: cell surface, cytoplasm, cytosol, endocytic vesicle, extrinsic component of cytoplasmic side of plasma membrane, membrane, plasma membrane, ruffle membrane
Pathways: AGE-RAGE pathway, Endogenous TLR signaling, Fibrin Complement Receptor 3 Signaling Pathway, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Lipid and atherosclerosis - Homo sapiens (human), NF-kappa B signaling pathway - Homo sapiens (human), PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Pertussis - Homo sapiens (human), RAGE, Regulation of toll-like receptor signaling pathway, Salmonella infection - Homo sapiens (human), TLR4 Signaling and Tolerance, Toll-like Receptor Signaling Pathway, Toll-like Receptor Signaling related to MyD88, Toll-like receptor signaling pathway - Homo sapiens (human), Tuberculosis - Homo sapiens (human), inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages, toll-like receptor pathway
UniProt: P58753
Entrez ID: 114609
|
Does Knockout of DEFB115 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
DEFB115
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: DEFB115 (defensin beta 115)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: defense response, defense response to Gram-negative bacterium, defense response to bacterium, innate immune response
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q30KQ5
Entrez ID: 245929
|
Does Knockout of SPAG9 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 1
| 1,339
|
Knockout
|
SPAG9
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: SPAG9 (sperm associated antigen 9)
Type: protein-coding
Summary: This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This protein also binds to kinesin-1 and may be involved in microtubule-based membrane transport. This protein may play a role in tumor growth and development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: MAPK cascade, lysosome localization, negative regulation of dendrite extension, negative regulation of neuron differentiation, positive regulation of MAPK cascade, positive regulation of cell migration, positive regulation of neuron differentiation, retrograde transport, endosome to Golgi, striated muscle cell differentiation, vesicle-mediated transport; MF: JUN kinase binding, MAP-kinase scaffold activity, identical protein binding, kinesin binding, protein binding, signaling receptor complex adaptor activity; CC: acrosomal vesicle, centriolar satellite, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm
Pathways: Arf6 trafficking events, Developmental Biology, Myogenesis, TNFalpha
UniProt: O60271
Entrez ID: 9043
|
Does Knockout of SLC25A26 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
SLC25A26
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: SLC25A26 (solute carrier family 25 member 26)
Type: protein-coding
Summary: This gene is a member of the mitochondrial carrier family which includes nuclear-encoded transporters localized on the inner mitochondrial membranes. Members of the family transport important small molecules across the mitochondrial inner membrane. This protein is involved in the transport of S-adenosylmethionine (SAM) into the mitochondria. Mutations in this gene are associated with combined oxidative phosphorylation deficiency 28. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017].
Gene Ontology: BP: L-alpha-amino acid transmembrane transport, S-adenosyl-L-methionine transport, macromolecule methylation, mitochondrial S-adenosyl-L-methionine transmembrane transport, monoatomic ion transport, purine nucleoside transmembrane transport; MF: S-adenosyl-L-methionine transmembrane transporter activity, S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity, antiporter activity; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: SLC-mediated transmembrane transport, SLC-mediated transport of organic cations, Transport of small molecules
UniProt: Q70HW3
Entrez ID: 115286
|
Does Knockout of TEAD1 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,391
|
Knockout
|
TEAD1
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: TEAD1 (TEA domain transcription factor 1)
Type: protein-coding
Summary: This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010].
Gene Ontology: BP: embryonic organ development, hippo signaling, positive regulation of DNA-templated transcription, positive regulation of cell growth, positive regulation of miRNA transcription, positive regulation of transcription by RNA polymerase II, protein-containing complex assembly, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: TEAD-YAP complex, chromatin, nucleoplasm, nucleus, transcription regulator complex
Pathways: Hippo signaling pathway - Homo sapiens (human), Hippo signaling pathway - multiple species - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Hippo-Yap signaling pathway, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Mesodermal commitment pathway, Overview of leukocyte-intrinsic Hippo pathway functions, Pathways Regulating Hippo Signaling, Transcription co-factors SKI and SKIL protein partners, miR-509-3p alteration of YAP1-ECM axis
UniProt: P28347
Entrez ID: 7003
|
Does Knockout of ZFP36L2 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
ZFP36L2
|
response to virus
|
Lung Cancer Cell Line
|
Gene: ZFP36L2 (ZFP36 ring finger protein like 2)
Type: protein-coding
Summary: This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, ERK1 and ERK2 cascade, MAPK cascade, T cell differentiation in thymus, cellular response to epidermal growth factor stimulus, cellular response to fibroblast growth factor stimulus, cellular response to glucocorticoid stimulus, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, definitive hemopoiesis, hemopoiesis, mRNA catabolic process, negative regulation of fat cell differentiation, negative regulation of mitotic cell cycle phase transition, negative regulation of stem cell differentiation, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, regulation of B cell differentiation, regulation of mRNA stability, response to wounding, somatic stem cell division, somatic stem cell population maintenance; MF: RNA binding, mRNA 3'-UTR AU-rich region binding, mRNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, nucleus, ribonucleoprotein complex
Pathways: Cellular senescence - Homo sapiens (human), Developmental Biology, M-decay: degradation of maternal mRNAs by maternally stored factors, Maternal to zygotic transition (MZT), Pre-implantation embryo, TYROBP causal network in microglia
UniProt: P47974
Entrez ID: 678
|
Does Knockout of OR1C1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
OR1C1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: OR1C1 (olfactory receptor family 1 subfamily C member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, GPCRs, Class A Rhodopsin-like, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q15619
Entrez ID: 26188
|
Does Knockout of HNRNPF in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
HNRNPF
|
cell proliferation
|
Cancer Cell Line
|
Gene: HNRNPF (heterogeneous nuclear ribonucleoprotein F)
Type: protein-coding
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, regulation of RNA splicing; MF: RNA binding, nucleic acid binding, protein binding, single-stranded RNA binding; CC: catalytic step 2 spliceosome, cytosol, membrane, nucleoplasm, nucleus, plasma membrane, ribonucleoprotein complex, spliceosomal complex, synapse
Pathways: Cytokine Signaling in Immune system, FGFR2 alternative splicing, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Immune System, Interleukin-12 family signaling, Interleukin-12 signaling, MECP2 and Associated Rett Syndrome, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P52597
Entrez ID: 3185
|
Does Knockout of NSMCE2 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
NSMCE2
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: NSMCE2 (NSE2 SUMO ligase component of SMC5/6 complex)
Type: protein-coding
Summary: This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell division, cellular senescence, chromatin looping, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, positive regulation of maintenance of mitotic sister chromatid cohesion, positive regulation of mitotic metaphase/anaphase transition, protein sumoylation, regulation of telomere maintenance, telomere maintenance via recombination; MF: SUMO ligase activity, SUMO transferase activity, metal ion binding, protein binding, transferase activity, zinc ion binding; CC: PML body, Smc5-Smc6 complex, chromosome, chromosome, telomeric region, nuclear body, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q96MF7
Entrez ID: 286053
|
Does Knockout of FDFT1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
FDFT1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Type: protein-coding
Summary: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol metabolic process, farnesyl diphosphate metabolic process, lipid biosynthetic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: catalytic activity, metal ion binding, protein binding, squalene synthase [NAD(P)H] activity, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Activation of gene expression by SREBF (SREBP), Alendronate Action Pathway, Atorvastatin Action Pathway, CHILD Syndrome, Cerivastatin Action Pathway, Cholesterol Biosynthesis Pathway, Cholesterol biosynthesis, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Cholesteryl ester storage disease, Chondrodysplasia Punctata II, X Linked Dominant (CDPX2), Desmosterolosis, Fluvastatin Action Pathway, Hyper-IgD syndrome, Hypercholesterolemia, Ibandronate Action Pathway, Lovastatin Action Pathway, Lysosomal Acid Lipase Deficiency (Wolman Disease), Metabolism, Metabolism of lipids, Metabolism of steroids, Mevalonic aciduria, PPARA activates gene expression, Pamidronate Action Pathway, Pravastatin Action Pathway, Regulation of cholesterol biosynthesis by SREBP (SREBF), Regulation of lipid metabolism by PPARalpha, Risedronate Action Pathway, Rosuvastatin Action Pathway, Simvastatin Action Pathway, Smith-Lemli-Opitz Syndrome (SLOS), Statin inhibition of cholesterol production, Steroid Biosynthesis, Steroid biosynthesis - Homo sapiens (human), Sterol regulatory element-binding proteins (SREBP) signaling, Wolman disease, Zoledronate Action Pathway, cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), epoxysqualene biosynthesis, superpathway of cholesterol biosynthesis
UniProt: P37268
Entrez ID: 2222
|
Does Activation of AFF1 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
AFF1
|
protein/peptide accumulation
|
T cell
|
Gene: AFF1 (ALF transcription elongation factor 1)
Type: protein-coding
Summary: This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: regulation of gene expression; CC: nucleus, super elongation complex, transcription elongation factor complex
Pathways: Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: P51825
Entrez ID: 4299
|
Does Knockout of DIMT1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
DIMT1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor)
Type: protein-coding
Summary: The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: methylation, positive regulation of rRNA processing, rRNA methylation, rRNA modification, rRNA processing, ribosomal small subunit biogenesis; MF: 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity, RNA binding, methyltransferase activity, rRNA (adenine-N6,N6-)-dimethyltransferase activity, transferase activity; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Metabolism of RNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9UNQ2
Entrez ID: 27292
|
Does Knockout of DCAF6 in Prostate Cancer Cell Line causally result in response to chemicals?
| 1
| 2,109
|
Knockout
|
DCAF6
|
response to chemicals
|
Prostate Cancer Cell Line
|
Gene: DCAF6 (DDB1 and CUL4 associated factor 6)
Type: protein-coding
Summary: The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, protein ubiquitination; MF: protein binding, transcription coactivator activity; CC: Cul4-RING E3 ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q58WW2
Entrez ID: 55827
|
Does Knockout of SUPT5H in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
SUPT5H
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: SUPT5H (SPT5 homolog, DSIF elongation factor subunit)
Type: protein-coding
Summary: Enables enzyme binding activity and protein heterodimerization activity. Involved in positive regulation of macroautophagy; regulation of RNA metabolic process; and transcription elongation from RNA polymerase II promoter. Located in nucleoplasm. Part of DSIF complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA-templated transcription elongation, negative regulation of DNA-templated transcription, elongation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, elongation, positive regulation of macroautophagy, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of DNA-templated transcription elongation, regulation of transcription by RNA polymerase II, regulation of transcription elongation by RNA polymerase II, transcription elongation by RNA polymerase II; MF: RNA binding, chromatin binding, enzyme binding, mRNA binding, protein binding, protein heterodimerization activity; CC: DSIF complex, nucleoplasm, nucleus
Pathways: Abortive elongation of HIV-1 transcript in the absence of Tat, Disease, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV elongation arrest and recovery, Infectious disease, Initiation of transcription and translation elongation at the HIV-1 LTR, Late Phase of HIV Life Cycle, Metabolism of RNA, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA polymerase II transcribes snRNA genes, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcriptional Regulation by TP53, Viral Infection Pathways, mRNA Capping, mRNA Processing
UniProt: O00267
Entrez ID: 6829
|
Does Knockout of ZMAT5 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
ZMAT5
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: ZMAT5 (zinc finger matrin-type 5)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in RNA splicing. Located in nucleoplasm. Part of U12-type spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing; MF: metal ion binding, protein binding, zinc ion binding; CC: U12-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Minor Pathway
UniProt: Q9UDW3
Entrez ID: 55954
|
Does Knockout of GTF2H4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
GTF2H4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: GTF2H4 (general transcription factor IIH subunit 4)
Type: protein-coding
Summary: Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, nucleotide-excision repair, transcription by RNA polymerase II; MF: ATPase activator activity, RNA polymerase II general transcription initiation factor activity, double-stranded DNA binding, protein binding; CC: core TFIIH complex portion of holo TFIIH complex, nuclear speck, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: AndrogenReceptor, Basal transcription factors - Homo sapiens (human), DNA Repair, DNA Repair Pathways Full Network, Disease, Dual Incision in GG-NER, Dual incision in TC-NER, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), mRNA Capping
UniProt: Q92759
Entrez ID: 2968
|
Does Knockout of NYNRIN in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
NYNRIN
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: NYNRIN (NYN domain and retroviral integrase containing)
Type: protein-coding
Summary: Predicted to enable endoribonuclease activity and mRNA binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Predicted to be integral component of membrane. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA integration, DNA synthesis involved in DNA repair, DNA-templated DNA replication, biological_process; MF: RNA endonuclease activity, RNA-DNA hybrid ribonuclease activity, mRNA binding, molecular_function, nucleic acid binding; CC: cellular_component, cytoplasmic ribonucleoprotein granule, membrane, nucleus
Pathways:
UniProt: Q9P2P1
Entrez ID: 57523
|
Does Activation of ANO4 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
ANO4
|
response to virus
|
Hepatoma Cell Line
|
Gene: ANO4 (anoctamin 4)
Type: protein-coding
Summary: Enables intracellular calcium activated chloride channel activity. Involved in chloride transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: calcium activated galactosylceramide scrambling, calcium activated phosphatidylcholine scrambling, calcium activated phosphatidylserine scrambling, chloride transmembrane transport, establishment of localization in cell, lipid transport, monoatomic ion transmembrane transport; MF: chloride channel activity, intracellularly calcium-gated chloride channel activity, phospholipid scramblase activity, protein dimerization activity; CC: membrane, plasma membrane
Pathways: Disease, Induction of Cell-Cell Fusion, Infectious disease, Ion channel transport, Late SARS-CoV-2 Infection Events, SARS-CoV Infections, SARS-CoV-2 Infection, Stimuli-sensing channels, Transport of small molecules, Viral Infection Pathways
UniProt: Q32M45
Entrez ID: 121601
|
Does Knockout of CHAC2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
CHAC2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: glutathione biosynthetic process, glutathione catabolic process; MF: gamma-glutamylcyclotransferase activity, glutathione specific gamma-glutamylcyclotransferase activity, lyase activity; CC: cytoplasm, cytosol
Pathways: Biological oxidations, Glutathione conjugation, Glutathione metabolism - Homo sapiens (human), Glutathione synthesis and recycling, Metabolism, Phase II - Conjugation of compounds
UniProt: Q8WUX2
Entrez ID: 494143
|
Does Knockout of FAM50B in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
FAM50B
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: FAM50B (family with sequence similarity 50 member B)
Type: protein-coding
Summary: This gene contains an intronless ORF that arose from ancestral retroposition. The encoded protein is related to a plant protein that plays a role in the circadian clock. This gene is adjacent to a differentially methylated region (DMR) and is imprinted and paternally expressed in many tissues. [provided by RefSeq, Nov 2015].
Gene Ontology: CC: intercellular bridge, midbody, nucleoplasm, nucleus
Pathways:
UniProt: Q9Y247
Entrez ID: 26240
|
Does Knockout of C2CD2L in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
C2CD2L
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: C2CD2L (C2CD2 like)
Type: protein-coding
Summary: Enables phosphatidylinositol binding activity and phosphatidylinositol transfer activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in cortical endoplasmic reticulum and endoplasmic reticulum-plasma membrane contact site. Colocalizes with cytoplasmic side of apical plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intermembrane lipid transfer, lipid transport, phospholipid transport, positive regulation of insulin secretion involved in cellular response to glucose stimulus; MF: insulin binding, lipid binding, phosphatidylinositol binding, phosphatidylinositol transfer activity, protein binding; CC: cortical endoplasmic reticulum, cytoplasmic side of apical plasma membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, membrane, plasma membrane
Pathways:
UniProt: O14523
Entrez ID: 9854
|
Does Activation of PHC1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
PHC1
|
response to virus
|
Hepatoma Cell Line
|
Gene: PHC1 (polyhomeotic homolog 1)
Type: protein-coding
Summary: This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, cellular response to retinoic acid, chromatin remodeling, negative regulation of DNA-templated transcription; MF: DNA binding, chromatin binding, histone binding, metal ion binding, protein binding, zinc ion binding; CC: PRC1 complex, PcG protein complex, nuclear body, nucleoplasm, nucleus, sex chromatin
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Gene expression (Transcription), Generic Transcription Pathway, Intracellular signaling by second messengers, Metabolism of proteins, Oxidative Stress Induced Senescence, PIP3 activates AKT signaling, PTEN Regulation, Post-translational protein modification, RNA Polymerase II Transcription, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known, Regulation of PTEN gene transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA methylation proteins, SUMOylation of RNA binding proteins, SUMOylation of chromatin organization proteins, SUMOylation of transcription cofactors, Signal Transduction, Transcriptional Regulation by E2F6, Transcriptional regulation by RUNX1, the prc2 complex sets long-term gene silencing through modification of histone tails
UniProt: P78364
Entrez ID: 1911
|
Does Knockout of BCAP31 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
BCAP31
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: BCAP31 (B cell receptor associated protein 31)
Type: protein-coding
Summary: This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: apoptotic process, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, positive regulation of ERAD pathway, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of retrograde protein transport, ER to cytosol, positive regulation of ubiquitin-dependent protein catabolic process, protein localization to endoplasmic reticulum exit site, protein targeting to mitochondrion, protein transport, response to endoplasmic reticulum stress, spermatogenesis, vesicle-mediated transport; MF: MHC class I protein binding, protein binding, protein-containing complex binding; CC: Golgi cisterna membrane, Golgi membrane, clathrin-coated vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, lipid droplet, lumenal side of endoplasmic reticulum membrane, membrane, mitochondria-associated endoplasmic reticulum membrane contact site, perinuclear endoplasmic reticulum, plasma membrane
Pathways: Adaptive Immune System, Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Apoptosis, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Class I MHC mediated antigen processing & presentation, Disease, Human papillomavirus infection - Homo sapiens (human), Immune System, Infectious disease, Programmed Cell Death, Protein processing in endoplasmic reticulum - Homo sapiens (human), RHO GTPase cycle, RHOA GTPase cycle, RSV-host interactions, Respiratory Syncytial Virus Infection Pathway, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Viral Infection Pathways
UniProt: P51572
Entrez ID: 10134
|
Does Knockout of RPL39L in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
RPL39L
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: RPL39L (ribosomal protein L39 like)
Type: protein-coding
Summary: This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: spermatogenesis, translation; MF: protein binding, structural constituent of ribosome; CC: cytoplasm, cytosolic large ribosomal subunit, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q96EH5
Entrez ID: 116832
|
Does Knockout of LSMEM1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
LSMEM1
|
response to virus
|
Hepatoma Cell Line
|
Gene: LSMEM1 (leucine rich single-pass membrane protein 1)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8N8F7
Entrez ID: 286006
|
Does Knockout of ZNF843 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
ZNF843
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: ZNF843 (zinc finger protein 843)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: Q8N446
Entrez ID: 283933
|
Does Knockout of ITGB5 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
ITGB5
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: ITGB5 (integrin subunit beta 5)
Type: protein-coding
Summary: This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: cell adhesion, cell adhesion mediated by integrin, cell migration, cell-cell adhesion, cell-matrix adhesion, endodermal cell differentiation, epithelial cell-cell adhesion, formation of primary germ layer, integrin-mediated signaling pathway, stress fiber assembly, symbiont entry into host cell, transforming growth factor beta receptor signaling pathway, wound healing, spreading of epidermal cells; MF: integrin binding, metal ion binding, protein binding, signaling receptor binding, virus receptor activity; CC: cell surface, extracellular exosome, focal adhesion, integrin alphav-beta5 complex, integrin complex, membrane, phagocytic vesicle, plasma membrane, receptor complex
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Beta5 beta6 beta7 and beta8 integrin cell surface interactions, Class I MHC mediated antigen processing & presentation, Cross-presentation of particulate exogenous antigens (phagosomes), Dilated cardiomyopathy - Homo sapiens (human), ECM proteoglycans, ECM-receptor interaction - Homo sapiens (human), Elastic fibre formation, Extracellular matrix organization, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Human papillomavirus infection - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Immune System, Integrin cell surface interactions, Integrin-mediated Cell Adhesion, Leptin, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Molecules associated with elastic fibres, Muscle contraction, Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Phagosome - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of nuclear SMAD2/3 signaling, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling events mediated by focal adhesion kinase, Smooth Muscle Contraction, Syndecan interactions, TGF-beta receptor signaling activates SMADs, Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling, VEGFA-VEGFR2 Signaling Pathway, miRNA targets in ECM and membrane receptors
UniProt: P18084
Entrez ID: 3693
|
Does Knockout of RIPK4 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
RIPK4
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: RIPK4 (receptor interacting serine/threonine kinase 4)
Type: protein-coding
Summary: The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: morphogenesis of an epithelium, positive regulation of NF-kappaB transcription factor activity, skin development; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, membrane, plasma membrane
Pathways: Pancreatic adenocarcinoma pathway
UniProt: Q96T11, Q9H4D1
Entrez ID: 54101
|
Does Knockout of SPATA33 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
SPATA33
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SPATA33 (spermatogenesis associated 33)
Type: protein-coding
Summary: Predicted to act upstream of or within cellular protein localization; fertilization; and flagellated sperm motility. Predicted to be located in sperm mitochondrial sheath. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagy, mitophagy; CC: cytoplasm, cytosol, mitochondrion, nucleus, sperm midpiece, sperm mitochondrial sheath
Pathways:
UniProt: Q96N06
Entrez ID: 124045
|
Does Knockout of OR7G3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
OR7G3
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: OR7G3 (olfactory receptor family 7 subfamily G member 3)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of chemical stimulus, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity, signaling receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NG95
Entrez ID: 390883
|
Does Knockout of RFT1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
RFT1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: RFT1 (RFT1 glycolipid translocator homolog)
Type: protein-coding
Summary: This gene encodes an enzyme which catalyzes the translocation of the Man(5)GlcNAc (2)-PP-Dol intermediate from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane in the pathway for the N-glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type In.[provided by RefSeq, Dec 2008].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, glycolipid translocation, protein N-linked glycosylation; MF: glycolipid floppase activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective RFT1 causes CDG-1n, Disease, Diseases associated with N-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, Post-translational protein modification
UniProt: Q96AA3
Entrez ID: 91869
|
Does Knockout of BCAS2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
BCAS2
|
cell proliferation
|
Cancer Cell Line
|
Gene: BCAS2 (BCAS2 pre-mRNA processing factor)
Type: protein-coding
Summary: Involved in mRNA splicing, via spliceosome. Located in centrosome and nuclear speck. Part of U2-type catalytic step 2 spliceosome. Colocalizes with DNA replication factor A complex. Implicated in breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, oocyte development, oogenesis, ovarian follicle development, protein catabolic process, spindle assembly; CC: DNA replication factor A complex, Prp19 complex, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, centrosome, nuclear speck, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O75934
Entrez ID: 10286
|
Does Knockout of ANKAR in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
ANKAR
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: ANKAR (ankyrin and armadillo repeat containing)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q7Z5J8
Entrez ID: 150709
|
Does Knockout of RPL35A in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
RPL35A
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RPL35A (ribosomal protein L35a)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Alternative splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: cytoplasmic translation, rRNA processing, ribosomal large subunit biogenesis, translation; MF: RNA binding, protein binding, structural constituent of ribosome, tRNA binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, membrane, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P18077
Entrez ID: 6165
|
Does Knockout of PGM3 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
PGM3
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PGM3 (phosphoglucomutase 3)
Type: protein-coding
Summary: This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nucleotide polymorphism in this gene may play a role in resistance to diabetic nephropathy and neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: UDP-N-acetylglucosamine biosynthetic process, carbohydrate metabolic process, glucosamine metabolic process, hemopoiesis, protein N-linked glycosylation, protein O-linked glycosylation, spermatogenesis; MF: intramolecular phosphotransferase activity, isomerase activity, magnesium ion binding, metal ion binding, phosphoacetylglucosamine mutase activity
Pathways: Amino Sugar Metabolism, Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, G(M2)-Gangliosidosis: Variant B, Tay-sachs disease, Glucuronidation, Metabolism of proteins, Post-translational protein modification, Salla Disease/Infantile Sialic Acid Storage Disease, Sialuria or French Type Sialuria, Synthesis of UDP-N-acetyl-glucosamine, Synthesis of substrates in N-glycan biosythesis, Tay-Sachs Disease, UDP-<i>N</i>-acetyl-D-galactosamine biosynthesis II, UDP-<i>N</i>-acetyl-D-glucosamine biosynthesis II
UniProt: O95394
Entrez ID: 5238
|
Does Knockout of SMIM5 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
SMIM5
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: SMIM5 (small integral membrane protein 5)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q71RC9
Entrez ID: 643008
|
Does Knockout of SHROOM1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
SHROOM1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SHROOM1 (shroom family member 1)
Type: protein-coding
Summary: SHROOM family members play diverse roles in the development of the nervous system and other tissues (Hagens et al., 2006 [PubMed 16615870]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: actin filament bundle assembly, cell morphogenesis; MF: actin binding, actin filament binding, myosin II binding; CC: adherens junction, apical junction complex, apical plasma membrane, cortical actin cytoskeleton, cytoplasm, cytoskeleton, microtubule
Pathways:
UniProt: Q2M3G4
Entrez ID: 134549
|
Does Knockout of ATP6AP1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
ATP6AP1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ATP6AP1 (ATPase H+ transporting accessory protein 1)
Type: protein-coding
Summary: This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: Golgi lumen acidification, cellular response to increased oxygen levels, endosomal lumen acidification, endosome to plasma membrane protein transport, intracellular iron ion homeostasis, intracellular pH reduction, lysosomal lumen acidification, monoatomic ion transport, osteoclast development, proton transmembrane transport, regulation of cellular pH, synaptic vesicle lumen acidification, vacuolar acidification; MF: ATPase activator activity, protein binding, small GTPase binding, transporter activator activity; CC: Golgi membrane, bounding membrane of organelle, clathrin-coated vesicle membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, endosome membrane, extracellular exosome, lysosomal membrane, membrane, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex, synapse, synaptic vesicle membrane
Pathways: Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Human papillomavirus infection - Homo sapiens (human), Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Homo sapiens (human), Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), RHO GTPase cycle, RHOA GTPase cycle, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Homo sapiens (human), Vibrio cholerae infection - Homo sapiens (human)
UniProt: Q15904
Entrez ID: 537
|
Does Knockout of ARFRP1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
ARFRP1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: ARFRP1 (ARF related protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golgi network and endosomes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2012].
Gene Ontology: BP: Golgi to plasma membrane protein transport, gastrulation, intracellular protein transport, protein localization to Golgi apparatus, retrograde transport, endosome to Golgi, signal transduction; MF: GTP binding, GTPase activity, nucleotide binding, protein binding; CC: Golgi apparatus, cytosol, membrane, trans-Golgi network, trans-Golgi network membrane
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q13795
Entrez ID: 10139
|
Does Knockout of DERL1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
DERL1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DERL1 (derlin 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: ERAD pathway, cellular response to misfolded protein, cellular response to stress, cellular response to unfolded protein, endoplasmic reticulum unfolded protein response, establishment of protein localization, positive regulation of protein ubiquitination, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein destabilization, protein transport, response to unfolded protein, retrograde protein transport, ER to cytosol; MF: ATPase binding, MHC class I protein binding, identical protein binding, protease binding, protein binding, protein-containing complex binding, signal recognition particle binding, signaling receptor activity, ubiquitin protein ligase binding, ubiquitin-specific protease binding; CC: Derlin-1 retrotranslocation complex, Derlin-1-VIMP complex, early endosome, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, late endosome, membrane
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Amyotrophic lateral sclerosis (ALS), Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, Co-inhibition by PD-1, Defective CFTR causes cystic fibrosis, Disease, Disorders of transmembrane transporters, E3 ubiquitin ligases ubiquitinate target proteins, Immune System, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Protein ubiquitination, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Transport of small molecules
UniProt: Q9BUN8
Entrez ID: 79139
|
Does Knockout of CWC22 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
CWC22
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CWC22 (CWC22 spliceosome associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nuclear speck. Part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, regulation of mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, catalytic step 2 spliceosome, cytosol, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9HCG8
Entrez ID: 57703
|
Does Knockout of BUD13 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
BUD13
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: BUD13 (BUD13 spliceosome associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: RES complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9BRD0
Entrez ID: 84811
|
Does Knockout of SNRNP40 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
SNRNP40
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SNRNP40 (small nuclear ribonucleoprotein U5 subunit 40)
Type: protein-coding
Summary: This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA processing, RNA splicing, RNA splicing, via transesterification reactions, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: U2-type catalytic step 2 spliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, cytosol, nuclear speck, nucleoplasm, nucleus, sno(s)RNA-containing ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q96DI7
Entrez ID: 9410
|
Does Knockout of NDUFB4 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
NDUFB4
|
cell proliferation
|
Bladder Carcinoma
|
Gene: NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4)
Type: protein-coding
Summary: This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009].
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; CC: membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human)
UniProt: O95168
Entrez ID: 4710
|
Does Knockout of MRPL38 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
MRPL38
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: MRPL38 (mitochondrial ribosomal protein L38)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: cytosol, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q96DV4
Entrez ID: 64978
|
Does Knockout of EIF5 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
EIF5
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: EIF5 (eukaryotic translation initiation factor 5)
Type: protein-coding
Summary: Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si et al., 1996 [PubMed 8663286]).[supplied by OMIM, May 2010].
Gene Ontology: BP: formation of cytoplasmic translation initiation complex, regulation of translational initiation, ribosome assembly, translation, translational initiation; MF: GDP-dissociation inhibitor activity, GTP binding, GTPase activator activity, RNA binding, cadherin binding, eukaryotic initiation factor eIF2 binding, nucleotide binding, protein binding, translation initiation factor activity; CC: cytoplasm, cytosol, nucleus, plasma membrane, synapse
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, GTP hydrolysis and joining of the 60S ribosomal subunit, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, eukaryotic protein translation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell, regulation of eif2
UniProt: P55010
Entrez ID: 1983
|
Does Knockout of DCTN6 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
DCTN6
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: DCTN6 (dynactin subunit 6)
Type: protein-coding
Summary: The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitotic spindle organization; MF: dynein complex binding; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, dynactin complex, kinetochore, microtubule cytoskeleton
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Salmonella infection - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, lissencephaly gene (lis1) in neuronal migration and development
UniProt: O00399
Entrez ID: 10671
|
Does Knockout of RPA3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
RPA3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPA3 (replication protein A3)
Type: protein-coding
Summary: Enables damaged DNA binding activity and single-stranded DNA binding activity. Involved in DNA repair and DNA replication. Part of DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA replication, base-excision repair, double-strand break repair via homologous recombination, mismatch repair, nucleotide-excision repair, regulation of cell population proliferation, regulation of mitotic cell cycle, telomere maintenance; MF: DNA binding, damaged DNA binding, protein binding, single-stranded DNA binding; CC: DNA replication factor A complex, nucleoplasm, nucleus, site of double-strand break
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA strand elongation, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Fanconi Anemia Pathway, Fanconi anemia pathway - Homo sapiens (human), Formation of Incision Complex in GG-NER, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), HSF1 activation, Homologous DNA Pairing and Strand Exchange, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Impaired BRCA2 binding to RAD51, Lagging Strand Synthesis, Meiosis, Meiotic recombination, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Homo sapiens (human), Mitotic G1 phase and G1/S transition, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of HSF1-mediated heat shock response, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Reproduction, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P35244
Entrez ID: 6119
|
Does Knockout of CCP110 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
CCP110
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: CCP110 (centriolar coiled-coil protein 110)
Type: protein-coding
Summary: Involved in centriole replication; negative regulation of cilium assembly; and regulation of cytokinesis. Located in centriole and centrosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell projection organization, centriole replication, centrosome duplication, ciliary basal body organization, negative regulation of cilium assembly, positive regulation of cilium assembly, regulation of cytokinesis; CC: cell projection, centriole, centrosome, cilium, cytoplasm, cytoskeleton, cytosol, microtubule organizing center, protein-containing complex
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, Deubiquitination, G2/M Transition, Genotoxicity pathway, Joubert Syndrome, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Post-translational protein modification, RHO GTPase cycle, RHOV GTPase cycle, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Ub-specific processing proteases
UniProt: O43303
Entrez ID: 9738
|
Does Knockout of DYNC1H1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
DYNC1H1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Type: protein-coding
Summary: Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: P-body assembly, cell division, cytoplasmic microtubule organization, establishment of spindle localization, microtubule-based movement, mitotic spindle organization, nuclear migration, positive regulation of cold-induced thermogenesis, positive regulation of intracellular transport, positive regulation of spindle assembly, regulation of metaphase plate congression, regulation of mitotic spindle organization, retrograde axonal transport, stress granule assembly; MF: ATP binding, RNA binding, dynein intermediate chain binding, dynein light intermediate chain binding, identical protein binding, minus-end-directed microtubule motor activity, nucleotide binding, protein binding; CC: axon cytoplasm, azurophil granule lumen, cell cortex, centrosome, cytoplasm, cytoplasmic dynein complex, cytoplasmic microtubule, cytoskeleton, cytosol, dynein complex, extracellular exosome, extracellular region, filopodium, membrane, microtubule
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Aggrephagy, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, Autophagy, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Ciliary landscape, Cilium Assembly, Disease, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HCMV Early Events, HCMV Infection, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Immune System, Infectious disease, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport proteins binding to dynein, Lissencephaly gene (LIS1) in neuronal migration and development, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Neutrophil degranulation, Organelle biogenesis and maintenance, Phagosome - Homo sapiens (human), Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Salmonella infection - Homo sapiens (human), Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q14204
Entrez ID: 1778
|
Does Knockout of MED30 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
MED30
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MED30 (mediator complex subunit 30)
Type: protein-coding
Summary: The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, somatic stem cell population maintenance; MF: nuclear thyroid hormone receptor binding, nuclear vitamin D receptor binding, protein binding, transcription coactivator activity, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Thyroid hormone signaling pathway - Homo sapiens (human), Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q96HR3
Entrez ID: 90390
|
Does Knockout of VCAM1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
VCAM1
|
cell proliferation
|
Cancer Cell Line
|
Gene: VCAM1 (vascular cell adhesion molecule 1)
Type: protein-coding
Summary: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: B cell differentiation, amine metabolic process, cardiac neuron differentiation, cell adhesion, cell chemotaxis, cell-cell adhesion, cell-cell adhesion mediated by integrin, cell-matrix adhesion, cellular response to amyloid-beta, cellular response to tumor necrosis factor, cellular response to vascular endothelial growth factor stimulus, chronic inflammatory response, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, heterotypic cell-cell adhesion, inflammatory response, innervation, leukocyte cell-cell adhesion, leukocyte tethering or rolling, membrane to membrane docking, positive regulation of T cell proliferation, response to ethanol, response to hypoxia, response to ionizing radiation, response to lipopolysaccharide, response to nicotine, response to nutrient, response to zinc ion; MF: cell adhesion mediator activity, cell adhesion molecule binding, integrin binding, primary methylamine oxidase activity; CC: Golgi apparatus, alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex, apical part of cell, cell surface, early endosome, endoplasmic reticulum, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, filopodium, membrane, microvillus, plasma membrane, podosome, sarcolemma
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Adaptive Immune System, African trypanosomiasis - Homo sapiens (human), Alpha4 beta1 integrin signaling events, Alpha9 beta1 integrin signaling events, Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, Beta1 integrin cell surface interactions, Beta2 integrin cell surface interactions, Beta5 beta6 beta7 and beta8 integrin cell surface interactions, CAMKK2 Pathway, Cell adhesion molecules - Homo sapiens (human), Cells and molecules involved in local acute inflammatory response, Cellular roles of Anthrax toxin, Cytokine Signaling in Immune system, Extracellular matrix organization, Fluid shear stress and atherosclerosis - Homo sapiens (human), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Integrin cell surface interactions, Interferon Signaling, Interferon gamma signaling, Interleukin-4 and Interleukin-13 signaling, Leukocyte transendothelial migration - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Malaria - Homo sapiens (human), NF-kappa B signaling pathway - Homo sapiens (human), Netrin-UNC5B signaling pathway, Nonalcoholic fatty liver disease, Photodynamic therapy-induced NF-kB survival signaling, RANKL-RANK signaling pathway, Signaling by Interleukins, TNF signaling pathway - Homo sapiens (human), Thromboxane A2 receptor signaling, a4b7 Integrin signaling, miRNAs involvement in the immune response in sepsis
UniProt: P19320
Entrez ID: 7412
|
Does Knockout of ZKSCAN1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
ZKSCAN1
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: ZKSCAN1 (zinc finger with KRAB and SCAN domains 1)
Type: protein-coding
Summary: This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric cancer and the encoded protein may stimulate migration and invasion of human gastric cancer cells. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: P17029
Entrez ID: 7586
|
Does Knockout of INO80C in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
INO80C
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: INO80C (INO80 complex subunit C)
Type: protein-coding
Summary: Predicted to be involved in chromatin remodeling. Part of Ino80 complex and MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin remodeling, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of telomere maintenance in response to DNA damage, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, telomere maintenance; CC: Ino80 complex, MLL1 complex, cytosol, fibrillar center, nucleoplasm, nucleus
Pathways: DNA Damage Recognition in GG-NER, DNA Repair, Deubiquitination, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of proteins, Nucleotide Excision Repair, Post-translational protein modification, UCH proteinases
UniProt: Q6PI98
Entrez ID: 125476
|
Does Knockout of ECHDC2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
ECHDC2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: ECHDC2 (enoyl-CoA hydratase domain containing 2)
Type: protein-coding
Summary: Predicted to enable enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: fatty acid beta-oxidation, fatty acid metabolic process, lipid metabolic process; MF: RNA binding, catalytic activity, enoyl-CoA hydratase activity, lyase activity; CC: mitochondrion
Pathways: Fatty Acid Biosynthesis
UniProt: Q86YB7
Entrez ID: 55268
|
Does Knockout of DDX21 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
DDX21
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: DDX21 (DExD-box helicase 21)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: R-loop processing, chromatin remodeling, defense response to virus, immune system process, innate immune response, negative regulation of transcription by RNA polymerase I, osteoblast differentiation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of macromolecule biosynthetic process, positive regulation of myeloid dendritic cell cytokine production, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, rRNA processing, regulation of gene expression, response to exogenous dsRNA, response to virus, transcription by RNA polymerase II; MF: 7SK snRNA binding, ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA polymerase inhibitor activity, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, mRNA binding, miRNA binding, nucleic acid binding, nucleotide binding, protein binding, rRNA binding, snoRNA binding; CC: B-WICH complex, chromosome, cytoplasm, cytosol, membrane, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Positive epigenetic regulation of rRNA expression, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NR30
Entrez ID: 9188
|
Does Knockout of ATP6V1G1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
ATP6V1G1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ATP6V1G1 (ATPase H+ transporting V1 subunit G1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to increased oxygen levels, intracellular iron ion homeostasis, monoatomic ion transport, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification; MF: ATP hydrolysis activity, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism; CC: ATPase complex, apical plasma membrane, cytosol, extracellular exosome, extrinsic component of synaptic vesicle membrane, lysosomal membrane, membrane, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V1 domain, synaptic vesicle membrane, vacuolar proton-transporting V-type ATPase complex, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Osteoclast Signaling, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, mTOR signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: O75348
Entrez ID: 9550
|
Does Knockout of POLR3A in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
POLR3A
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: POLR3A (RNA polymerase III subunit A)
Type: protein-coding
Summary: The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: DNA-templated transcription, defense response to virus, immune system process, innate immune response, positive regulation of gene expression, positive regulation of interferon-beta production, tRNA transcription by RNA polymerase III; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, DNA/RNA hybrid binding, chromatin binding, magnesium ion binding, metal ion binding, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, cytoplasm, cytosol, membrane, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , Gene expression (Transcription), Immune System, Innate Immune System, Pyrimidine metabolism, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human)
UniProt: O14802
Entrez ID: 11128
|
Does Knockout of RHBDF1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
RHBDF1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: RHBDF1 (rhomboid 5 homolog 1)
Type: protein-coding
Summary: Predicted to enable growth factor binding activity and serine-type endopeptidase activity. Involved in several processes, including negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway; and regulation of proteasomal protein catabolic process. Located in Golgi membrane and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell migration, cell population proliferation, negative regulation of protein secretion, protein transport, regulation of epidermal growth factor receptor signaling pathway, regulation of proteasomal protein catabolic process, regulation of protein secretion; MF: growth factor binding, protein binding, serine-type endopeptidase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q96CC6
Entrez ID: 64285
|
Does Knockout of MIR5691 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
MIR5691
|
response to virus
|
Hepatoma Cell Line
|
Gene: MIR5691 (microRNA 5691)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100847015
|
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