prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of PLAC1 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | PLAC1 | cell proliferation | Cancer Cell Line | Gene: PLAC1 (placenta enriched 1)
Type: protein-coding
Summary: Involved in placenta development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: placenta development
Pathways:
UniProt: Q9HBJ0
En... |
Does Knockout of GOLGA6A in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | GOLGA6A | cell proliferation | Monocytic Leukemia Cell Line | Gene: GOLGA6A (golgin A6 family member A)
Type: protein-coding
Summary: The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtub... |
Does Knockout of HDAC9 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | HDAC9 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: HDAC9 (histone deacetylase 9)
Type: protein-coding
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encod... |
Does Knockout of SRP19 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | SRP19 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: SRP19 (signal recognition particle 19)
Type: protein-coding
Summary: Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal... |
Does Knockout of CHAF1B in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | CHAF1B | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: CHAF1B (chromatin assembly factor 1 subunit B)
Type: protein-coding
Summary: Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds... |
Does Knockout of EIF3I in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | EIF3I | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: EIF3I (eukaryotic translation initiation factor 3 subunit I)
Type: protein-coding
Summary: Contributes to translation initiation factor activity. Involved in translational initiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Allianc... |
Does Knockout of GRIA3 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | GRIA3 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: GRIA3 (glutamate ionotropic receptor AMPA type subunit 3)
Type: protein-coding
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein ... |
Does Knockout of ATP6V1H in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | ATP6V1H | cell proliferation | Bladder Carcinoma | Gene: ATP6V1H (ATPase H+ transporting V1 subunit H)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes inc... |
Does Knockout of ZBTB45 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | ZBTB45 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ZBTB45 (zinc finger and BTB domain containing 45)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resou... |
Does Knockout of NXF2 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | NXF2 | cell proliferation | Gastric Cancer Cell Line | Gene: NXF2 (nuclear RNA export factor 2)
Type: protein-coding
Summary: This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on c... |
Does Knockout of LYNX1 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | LYNX1 | cell proliferation | Cancer Cell Line | Gene: LYNX1 (Ly6/neurotoxin 1)
Type: protein-coding
Summary: This gene encodes a GPI-anchored, cell membrane bound member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This protein interacts with nicotinic acetylcholine receptors (nAChRs), and is thought to f... |
Does Knockout of MAEL in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | MAEL | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: MAEL (maelstrom spermatogenic transposon silencer)
Type: protein-coding
Summary: Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in gamete generation; negative regulation of macromolecule metabolic process; and piRNA metabolic process. Predicted to act upstream... |
Does Knockout of SPRY2 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | SPRY2 | cell proliferation | Hepatoma Cell Line | Gene: SPRY2 (sprouty RTK signaling antagonist 2)
Type: protein-coding
Summary: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is re... |
Does Knockout of MBL2 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | MBL2 | cell proliferation | Glioblastoma Cell Line | Gene: MBL2 (mannose binding lectin 2)
Type: protein-coding
Summary: This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and bind... |
Does Knockout of CLDN16 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | CLDN16 | cell proliferation | Endometrial Cancer Cell Line | Gene: CLDN16 (claudin 16)
Type: protein-coding
Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular ... |
Does Knockout of PXT1 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | PXT1 | cell proliferation | Renal Cancer Cell Line | Gene: PXT1 (peroxisomal testis enriched protein 1)
Type: protein-coding
Summary: Predicted to be involved in positive regulation of apoptotic process. Predicted to act upstream of or within spermatogenesis. Predicted to be active in nucleus and peroxisome. [provided by Alliance of Genome Resources, Apr ... |
Does Knockout of NREP in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | NREP | cell proliferation | Multiple Myeloma Cell Line | Gene: NREP (neuronal regeneration related protein)
Type: protein-coding
Summary: Predicted to be involved in axon regeneration; regulation of neuron differentiation; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in cytoplasm and nucleus. [provided b... |
Does Knockout of TNS2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | TNS2 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: TNS2 (tensin 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs... |
Does Knockout of AHCY in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | AHCY | cell proliferation | Melanoma Cell Line | Gene: AHCY (adenosylhomocysteinase)
Type: protein-coding
Summary: S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-a... |
Does Knockout of SIGLEC11 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | SIGLEC11 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: SIGLEC11 (sialic acid binding Ig like lectin 11)
Type: protein-coding
Summary: This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognit... |
Does Knockout of SYK in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | SYK | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: SYK (spleen associated tyrosine kinase)
Type: protein-coding
Summary: This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that... |
Does Knockout of NCKAP1 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | NCKAP1 | cell proliferation | Cancer Cell Line | Gene: NCKAP1 (NCK associated protein 1)
Type: protein-coding
Summary: Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of lamellipodium assembly. Located in extracellular ex... |
Does Knockout of RNF223 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | RNF223 | cell proliferation | Neuroblastoma Cell Line | Gene: RNF223 (ring finger protein 223)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, ubiquitin protein ligase activity, zinc... |
Does Knockout of DDX6 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | DDX6 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: DDX6 (DEAD-box helicase 6)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencin... |
Does Knockout of MRPS23 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | MRPS23 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: MRPS23 (mitochondrial ribosomal protein S23)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of GPT2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | GPT2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: GPT2 (glutamic--pyruvic transaminase 2)
Type: protein-coding
Summary: This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in g... |
Does Knockout of IMP3 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | IMP3 | cell proliferation | Endometrial Cancer Cell Line | Gene: IMP3 (IMP U3 small nucleolar ribonucleoprotein 3)
Type: protein-coding
Summary: This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008].
... |
Does Knockout of NPB in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | NPB | cell proliferation | Medulloblastoma Cell Line | Gene: NPB (neuropeptide B)
Type: protein-coding
Summary: This gene encodes a member of the neuropeptide B/W family of proteins and preproprotein that is proteolytically processed to generate multiple protein products. The encoded products include neuropeptide B-23 and a C-terminally extended form, neuro... |
Does Knockout of MRPS34 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | MRPS34 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: MRPS34 (mitochondrial ribosomal protein S34)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of RHEB in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | RHEB | cell proliferation | Prostate Cancer Cell Line | Gene: RHEB (Ras homolog, mTORC1 binding)
Type: protein-coding
Summary: This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progressi... |
Does Knockout of TBC1D28 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | TBC1D28 | cell proliferation | Colonic Cancer Cell Line | Gene: TBC1D28 (TBC1 domain family member 28)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
... |
Does Knockout of AP4E1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | AP4E1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: AP4E1 (adaptor related protein complex 4 subunit epsilon 1)
Type: protein-coding
Summary: This gene encodes a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory a... |
Does Knockout of ORC5 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | ORC5 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: ORC5 (origin recognition complex subunit 5)
Type: protein-coding
Summary: The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to ori... |
Does Knockout of RGS7BP in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | RGS7BP | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: RGS7BP (regulator of G protein signaling 7 binding protein)
Type: protein-coding
Summary: This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protei... |
Does Knockout of ZKSCAN7 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | ZKSCAN7 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ZKSCAN7 (zinc finger with KRAB and SCAN domains 7)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of t... |
Does Knockout of RPL38 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | RPL38 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: RPL38 (ribosomal protein L38)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of TMC3 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | TMC3 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: TMC3 (transmembrane channel like 3)
Type: protein-coding
Summary: Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of PDE1B in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | PDE1B | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: PDE1B (phosphodiesterase 1B)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE ha... |
Does Knockout of WASHC4 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | WASHC4 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: WASHC4 (WASH complex subunit 4)
Type: protein-coding
Summary: This gene encodes a component of the WASH complex, which functions in the intracellular transport of endosomes. Mutations in this gene have been detected in individuals with autosomal recessive cognitive disability. Alternative splicing... |
Does Knockout of RAD1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | RAD1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: RAD1 (RAD1 checkpoint DNA exonuclease)
Type: protein-coding
Summary: This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 comp... |
Does Knockout of TIRAP in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | TIRAP | cell proliferation | Monocytic Leukemia Cell Line | Gene: TIRAP (TIR domain containing adaptor protein)
Type: protein-coding
Summary: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns a... |
Does Knockout of DEFB115 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | DEFB115 | cell proliferation | Endometrial Cancer Cell Line | Gene: DEFB115 (defensin beta 115)
Type: protein-coding
Summary: Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. A... |
Does Knockout of SPAG9 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 1 | 1,339 | Knockout | SPAG9 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: SPAG9 (sperm associated antigen 9)
Type: protein-coding
Summary: This gene encodes a member of the cancer testis antigen gene family. The encoded protein functions as a scaffold protein that structurally organizes mitogen-activated protein kinases and mediates c-Jun-terminal kinase signaling. This... |
Does Knockout of SLC25A26 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | SLC25A26 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: SLC25A26 (solute carrier family 25 member 26)
Type: protein-coding
Summary: This gene is a member of the mitochondrial carrier family which includes nuclear-encoded transporters localized on the inner mitochondrial membranes. Members of the family transport important small molecules across the mit... |
Does Knockout of TEAD1 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,391 | Knockout | TEAD1 | response to chemicals | Non-Small Cell Lung Adenocarcinoma Cell Line | Gene: TEAD1 (TEA domain transcription factor 1)
Type: protein-coding
Summary: This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcr... |
Does Knockout of ZFP36L2 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | ZFP36L2 | response to virus | Lung Cancer Cell Line | Gene: ZFP36L2 (ZFP36 ring finger protein like 2)
Type: protein-coding
Summary: This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing pu... |
Does Knockout of OR1C1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | OR1C1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: OR1C1 (olfactory receptor family 1 subfamily C member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of HNRNPF in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | HNRNPF | cell proliferation | Cancer Cell Line | Gene: HNRNPF (heterogeneous nuclear ribonucleoprotein F)
Type: protein-coding
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins a... |
Does Knockout of NSMCE2 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | NSMCE2 | cell proliferation | Multiple Myeloma Cell Line | Gene: NSMCE2 (NSE2 SUMO ligase component of SMC5/6 complex)
Type: protein-coding
Summary: This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segre... |
Does Knockout of FDFT1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | FDFT1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: FDFT1 (farnesyl-diphosphate farnesyltransferase 1)
Type: protein-coding
Summary: This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two mole... |
Does Activation of AFF1 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | AFF1 | protein/peptide accumulation | T cell | Gene: AFF1 (ALF transcription elongation factor 1)
Type: protein-coding
Summary: This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X inte... |
Does Knockout of DIMT1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | DIMT1 | cell proliferation | Bladder Carcinoma | Gene: DIMT1 (DIM1 rRNA methyltransferase and ribosome maturation factor)
Type: protein-coding
Summary: The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome bioge... |
Does Knockout of DCAF6 in Prostate Cancer Cell Line causally result in response to chemicals? | 1 | 2,109 | Knockout | DCAF6 | response to chemicals | Prostate Cancer Cell Line | Gene: DCAF6 (DDB1 and CUL4 associated factor 6)
Type: protein-coding
Summary: The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded pr... |
Does Knockout of SUPT5H in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | SUPT5H | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: SUPT5H (SPT5 homolog, DSIF elongation factor subunit)
Type: protein-coding
Summary: Enables enzyme binding activity and protein heterodimerization activity. Involved in positive regulation of macroautophagy; regulation of RNA metabolic process; and transcription elongation from RNA polymerase II p... |
Does Knockout of ZMAT5 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | ZMAT5 | cell proliferation | Multiple Myeloma Cell Line | Gene: ZMAT5 (zinc finger matrin-type 5)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in RNA splicing. Located in nucleoplasm. Part of U12-type spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: R... |
Does Knockout of GTF2H4 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | GTF2H4 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: GTF2H4 (general transcription factor IIH subunit 4)
Type: protein-coding
Summary: Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and trans... |
Does Knockout of NYNRIN in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | NYNRIN | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: NYNRIN (NYN domain and retroviral integrase containing)
Type: protein-coding
Summary: Predicted to enable endoribonuclease activity and mRNA binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Predicted to be integral component of membrane. Predicted ... |
Does Activation of ANO4 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | ANO4 | response to virus | Hepatoma Cell Line | Gene: ANO4 (anoctamin 4)
Type: protein-coding
Summary: Enables intracellular calcium activated chloride channel activity. Involved in chloride transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: calcium activated galactosylceramide scra... |
Does Knockout of CHAC2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | CHAC2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CHAC2 (ChaC glutathione specific gamma-glutamylcyclotransferase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in r... |
Does Knockout of FAM50B in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | FAM50B | cell proliferation | Endometrial Cancer Cell Line | Gene: FAM50B (family with sequence similarity 50 member B)
Type: protein-coding
Summary: This gene contains an intronless ORF that arose from ancestral retroposition. The encoded protein is related to a plant protein that plays a role in the circadian clock. This gene is adjacent to a differentially met... |
Does Knockout of C2CD2L in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | C2CD2L | response to chemicals | Monocytic Leukemia Cell Line | Gene: C2CD2L (C2CD2 like)
Type: protein-coding
Summary: Enables phosphatidylinositol binding activity and phosphatidylinositol transfer activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in cortical endoplasmic reticulum and endoplas... |
Does Activation of PHC1 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | PHC1 | response to virus | Hepatoma Cell Line | Gene: PHC1 (polyhomeotic homolog 1)
Type: protein-coding
Summary: This gene is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The... |
Does Knockout of BCAP31 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | BCAP31 | cell proliferation | Colonic Cancer Cell Line | Gene: BCAP31 (B cell receptor associated protein 31)
Type: protein-coding
Summary: This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of ... |
Does Knockout of RPL39L in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | RPL39L | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: RPL39L (ribosomal protein L39 like)
Type: protein-coding
Summary: This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein... |
Does Knockout of LSMEM1 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | LSMEM1 | response to virus | Hepatoma Cell Line | Gene: LSMEM1 (leucine rich single-pass membrane protein 1)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8N8F7
Entrez ID: 286006 |
Does Knockout of ZNF843 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | ZNF843 | cell proliferation | Astrocytoma Cell Line | Gene: ZNF843 (zinc finger protein 843)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding
... |
Does Knockout of ITGB5 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | ITGB5 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: ITGB5 (integrin subunit beta 5)
Type: protein-coding
Summary: This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surf... |
Does Knockout of RIPK4 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | RIPK4 | cell proliferation | Glioblastoma Cell Line | Gene: RIPK4 (receptor interacting serine/threonine kinase 4)
Type: protein-coding
Summary: The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. Th... |
Does Knockout of SPATA33 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | SPATA33 | cell proliferation | Medulloblastoma Cell Line | Gene: SPATA33 (spermatogenesis associated 33)
Type: protein-coding
Summary: Predicted to act upstream of or within cellular protein localization; fertilization; and flagellated sperm motility. Predicted to be located in sperm mitochondrial sheath. Predicted to be active in cytoplasm and nucleus. [provid... |
Does Knockout of OR7G3 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | OR7G3 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: OR7G3 (olfactory receptor family 7 subfamily G member 3)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of RFT1 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | RFT1 | cell proliferation | Melanoma Cell Line | Gene: RFT1 (RFT1 glycolipid translocator homolog)
Type: protein-coding
Summary: This gene encodes an enzyme which catalyzes the translocation of the Man(5)GlcNAc (2)-PP-Dol intermediate from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane in the pathway for the N-glycosylation ... |
Does Knockout of BCAS2 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | BCAS2 | cell proliferation | Cancer Cell Line | Gene: BCAS2 (BCAS2 pre-mRNA processing factor)
Type: protein-coding
Summary: Involved in mRNA splicing, via spliceosome. Located in centrosome and nuclear speck. Part of U2-type catalytic step 2 spliceosome. Colocalizes with DNA replication factor A complex. Implicated in breast cancer. [provided by All... |
Does Knockout of ANKAR in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | ANKAR | cell proliferation | Renal Cancer Cell Line | Gene: ANKAR (ankyrin and armadillo repeat containing)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q7Z5J8
Entrez ID: 150709 |
Does Knockout of RPL35A in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | RPL35A | cell proliferation | Monocytic Leukemia Cell Line | Gene: RPL35A (ribosomal protein L35a)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene enco... |
Does Knockout of PGM3 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | PGM3 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: PGM3 (phosphoglucomutase 3)
Type: protein-coding
Summary: This gene encodes a member of the phosphohexose mutase family. The encoded protein mediates both glycogen formation and utilization by catalyzing the interconversion of glucose-1-phosphate and glucose-6-phosphate. A non-synonymous single nu... |
Does Knockout of SMIM5 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | SMIM5 | cell proliferation | Ovarian Cancer Cell Line | Gene: SMIM5 (small integral membrane protein 5)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q71RC9
Entrez ID: 643008 |
Does Knockout of SHROOM1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | SHROOM1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SHROOM1 (shroom family member 1)
Type: protein-coding
Summary: SHROOM family members play diverse roles in the development of the nervous system and other tissues (Hagens et al., 2006 [PubMed 16615870]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: actin filament bundle assembly, cell ... |
Does Knockout of ATP6AP1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | ATP6AP1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ATP6AP1 (ATPase H+ transporting accessory protein 1)
Type: protein-coding
Summary: This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) a... |
Does Knockout of ARFRP1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | ARFRP1 | cell proliferation | Bladder Carcinoma | Gene: ARFRP1 (ARF related protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking betw... |
Does Knockout of DERL1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | DERL1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: DERL1 (derlin 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degrad... |
Does Knockout of CWC22 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | CWC22 | cell proliferation | Endometrial Cancer Cell Line | Gene: CWC22 (CWC22 spliceosome associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nuclear speck. Part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic sp... |
Does Knockout of BUD13 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | BUD13 | cell proliferation | Medulloblastoma Cell Line | Gene: BUD13 (BUD13 spliceosome associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RN... |
Does Knockout of SNRNP40 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | SNRNP40 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SNRNP40 (small nuclear ribonucleoprotein U5 subunit 40)
Type: protein-coding
Summary: This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger R... |
Does Knockout of NDUFB4 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | NDUFB4 | cell proliferation | Bladder Carcinoma | Gene: NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4)
Type: protein-coding
Summary: This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 d... |
Does Knockout of MRPL38 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | MRPL38 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: MRPL38 (mitochondrial ribosomal protein L38)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of EIF5 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | EIF5 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: EIF5 (eukaryotic translation initiation factor 5)
Type: protein-coding
Summary: Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The re... |
Does Knockout of DCTN6 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | DCTN6 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: DCTN6 (dynactin subunit 6)
Type: protein-coding
Summary: The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homol... |
Does Knockout of RPA3 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | RPA3 | cell proliferation | Colonic Cancer Cell Line | Gene: RPA3 (replication protein A3)
Type: protein-coding
Summary: Enables damaged DNA binding activity and single-stranded DNA binding activity. Involved in DNA repair and DNA replication. Part of DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontolo... |
Does Knockout of CCP110 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | CCP110 | cell proliferation | Medulloblastoma Cell Line | Gene: CCP110 (centriolar coiled-coil protein 110)
Type: protein-coding
Summary: Involved in centriole replication; negative regulation of cilium assembly; and regulation of cytokinesis. Located in centriole and centrosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Ap... |
Does Knockout of DYNC1H1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | DYNC1H1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Type: protein-coding
Summary: Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, in... |
Does Knockout of MED30 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | MED30 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: MED30 (mediator complex subunit 30)
Type: protein-coding
Summary: The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976])... |
Does Knockout of VCAM1 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | VCAM1 | cell proliferation | Cancer Cell Line | Gene: VCAM1 (vascular cell adhesion molecule 1)
Type: protein-coding
Summary: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transdu... |
Does Knockout of ZKSCAN1 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | ZKSCAN1 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: ZKSCAN1 (zinc finger with KRAB and SCAN domains 1)
Type: protein-coding
Summary: This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Tran... |
Does Knockout of INO80C in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | INO80C | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: INO80C (INO80 complex subunit C)
Type: protein-coding
Summary: Predicted to be involved in chromatin remodeling. Part of Ino80 complex and MLL1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin re... |
Does Knockout of ECHDC2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | ECHDC2 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: ECHDC2 (enoyl-CoA hydratase domain containing 2)
Type: protein-coding
Summary: Predicted to enable enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontolo... |
Does Knockout of DDX21 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | DDX21 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: DDX21 (DExD-box helicase 21)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiatio... |
Does Knockout of ATP6V1G1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | ATP6V1G1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ATP6V1G1 (ATPase H+ transporting V1 subunit G1)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intr... |
Does Knockout of POLR3A in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | POLR3A | cell proliferation | Monocytic Leukemia Cell Line | Gene: POLR3A (RNA polymerase III subunit A)
Type: protein-coding
Summary: The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by R... |
Does Knockout of RHBDF1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | RHBDF1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: RHBDF1 (rhomboid 5 homolog 1)
Type: protein-coding
Summary: Predicted to enable growth factor binding activity and serine-type endopeptidase activity. Involved in several processes, including negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway... |
Does Knockout of MIR5691 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | MIR5691 | response to virus | Hepatoma Cell Line | Gene: MIR5691 (microRNA 5691)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
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