prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of COA7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | COA7 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: COA7 (cytochrome c oxidase assembly factor 7)
Type: protein-coding
Summary: Located in mitochondrial intermembrane space and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, protein-disulfide reductase activity; CC: mitochondrial interm... |
Does Knockout of MRPS23 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | MRPS23 | cell proliferation | T-lymphoma cell line | Gene: MRPS23 (mitochondrial ribosomal protein S23)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of SH2D3C in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | SH2D3C | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: SH2D3C (SH2 domain containing 3C)
Type: protein-coding
Summary: This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which a... |
Does Knockout of ZIC5 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | ZIC5 | cell proliferation | Cancer Cell Line | Gene: ZIC5 (Zic family zinc finger 5)
Type: protein-coding
Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. The encoded protein may act as a transcriptional repressor. Studies in mouse and Xenopus support a role for this gene in neural crest development. Elevated ... |
Does Knockout of POLD1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | POLD1 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: POLD1 (DNA polymerase delta 1, catalytic subunit)
Type: protein-coding
Summary: This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alterna... |
Does Knockout of PSME2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | PSME2 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: PSME2 (proteasome activator subunit 2)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are comp... |
Does Knockout of EIF2B1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | EIF2B1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha)
Type: protein-coding
Summary: This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis.... |
Does Knockout of NAA20 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | NAA20 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit)
Type: protein-coding
Summary: NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 20... |
Does Knockout of YBEY in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | YBEY | cell proliferation | Gastric Cancer Cell Line | Gene: YBEY (ybeY metalloendoribonuclease)
Type: protein-coding
Summary: This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple t... |
Does Knockout of KCNS2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | KCNS2 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: KCNS2 (potassium voltage-gated channel modifier subfamily S member 2)
Type: protein-coding
Summary: Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of delayed rectifier potassium channel activity. Predic... |
Does Knockout of CASC3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | CASC3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CASC3 (CASC3 exon junction complex subunit)
Type: protein-coding
Summary: The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded pr... |
Does Knockout of MRPL33 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | MRPL33 | cell proliferation | Glioblastoma Cell Line | Gene: MRPL33 (mitochondrial ribosomal protein L33)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of TTC16 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | TTC16 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: TTC16 (tetratricopeptide repeat domain 16)
Type: protein-coding
Summary: tetratricopeptide repeat domain 16
Gene Ontology:
Pathways:
UniProt: Q8NEE8
Entrez ID: 158248 |
Does Knockout of AMPD1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | AMPD1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: AMPD1 (adenosine monophosphate deaminase 1)
Type: protein-coding
Summary: Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver-... |
Does Knockout of HNRNPC in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | HNRNPC | cell proliferation | Ovarian Cancer Cell Line | Gene: HNRNPC (heterogeneous nuclear ribonucleoprotein C)
Type: protein-coding
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These protei... |
Does Knockout of DAGLB in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | DAGLB | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: DAGLB (diacylglycerol lipase beta)
Type: protein-coding
Summary: Enables lipase activity. Involved in arachidonic acid metabolic process. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: arachidonate metabolic process, can... |
Does Knockout of SERTAD3 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | SERTAD3 | response to virus | Hepatoma Cell Line | Gene: SERTAD3 (SERTA domain containing 3)
Type: protein-coding
Summary: The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cel... |
Does Knockout of RPH3AL in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | RPH3AL | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: RPH3AL (rabphilin 3A like (without C2 domains))
Type: protein-coding
Summary: The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely ... |
Does Knockout of ARHGEF7 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | ARHGEF7 | cell proliferation | Neuroblastoma Cell Line | Gene: ARHGEF7 (Rho guanine nucleotide exchange factor 7)
Type: protein-coding
Summary: This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac... |
Does Activation of HSPA12B in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | HSPA12B | protein/peptide accumulation | T cell | Gene: HSPA12B (heat shock protein family A (Hsp70) member 12B)
Type: protein-coding
Summary: The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to a... |
Does Knockout of CRLS1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | CRLS1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: CRLS1 (cardiolipin synthase 1)
Type: protein-coding
Summary: This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitocho... |
Does Knockout of EIF1AX in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | EIF1AX | cell proliferation | Cancer Cell Line | Gene: EIF1AX (eukaryotic translation initiation factor 1A X-linked)
Type: protein-coding
Summary: This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. ... |
Does Knockout of NCL in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | NCL | cell proliferation | Medulloblastoma Cell Line | Gene: NCL (nucleolin)
Type: protein-coding
Summary: Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximat... |
Does Knockout of PAPSS1 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | PAPSS1 | cell proliferation | Cancer Cell Line | Gene: PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1)
Type: protein-coding
Summary: Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of... |
Does Knockout of PSMA4 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | PSMA4 | cell proliferation | Cancer Cell Line | Gene: PSMA4 (proteasome 20S subunit alpha 4)
Type: protein-coding
Summary: This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent man... |
Does Knockout of BTBD9 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | BTBD9 | cell proliferation | Medulloblastoma Cell Line | Gene: BTBD9 (BTB domain containing 9)
Type: protein-coding
Summary: This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome a... |
Does Knockout of SLU7 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | SLU7 | cell proliferation | Colonic Cancer Cell Line | Gene: SLU7 (spliceosome associated SLU7)
Type: protein-coding
Summary: Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It ass... |
Does Activation of DUSP3 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | DUSP3 | protein/peptide accumulation | T cell | Gene: DUSP3 (dual specificity phosphatase 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine resi... |
Does Knockout of RPL38 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | RPL38 | cell proliferation | Cancer Cell Line | Gene: RPL38 (ribosomal protein L38)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of ACP6 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | ACP6 | cell proliferation | Multiple Myeloma Cell Line | Gene: ACP6 (acid phosphatase 6, lysophosphatidic)
Type: protein-coding
Summary: This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in bala... |
Does Knockout of NUP98 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | NUP98 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: NUP98 (nucleoporin 98 and 96 precursor)
Type: protein-coding
Summary: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nu... |
Does Knockout of BRD8 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | BRD8 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: BRD8 (bromodomain containing 8)
Type: protein-coding
Summary: The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought t... |
Does Knockout of CEACAM16 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | CEACAM16 | cell proliferation | Cancer Cell Line | Gene: CEACAM16 (CEA cell adhesion molecule 16, tectorial membrane component)
Type: protein-coding
Summary: The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair c... |
Does Knockout of MYO1H in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | MYO1H | cell proliferation | Bladder Carcinoma | Gene: MYO1H (myosin IH)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to be part of myosin complex. Predicted to be active i... |
Does Knockout of DHX8 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | DHX8 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: DHX8 (DEAH-box helicase 8)
Type: protein-coding
Summary: This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regula... |
Does Knockout of ARL9 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | ARL9 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: ARL9 (ARF like GTPase 9)
Type: protein-coding
Summary: ARL9 is a member of the small GTPase protein family with a high degree of similarity to ARF (MIM 103180) proteins of the RAS superfamily.[supplied by OMIM, Nov 2008].
Gene Ontology: MF: GTP binding, GTPase activity, nucleotide binding... |
Does Knockout of SMC4 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | SMC4 | cell proliferation | Ovarian Cancer Cell Line | Gene: SMC4 (structural maintenance of chromosomes 4)
Type: protein-coding
Summary: This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome cond... |
Does Knockout of DCAF6 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | DCAF6 | cell proliferation | Astrocytoma Cell Line | Gene: DCAF6 (DDB1 and CUL4 associated factor 6)
Type: protein-coding
Summary: The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded pr... |
Does Knockout of RPE65 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | RPE65 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: RPE65 (retinoid isomerohydrolase RPE65)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxy... |
Does Knockout of PSMD7 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | PSMD7 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: PSMD7 (proteasome 26S subunit, non-ATPase 7)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings ar... |
Does Knockout of NOCT in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | NOCT | cell proliferation | T-lymphoma cell line | Gene: NOCT (nocturnin)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, c... |
Does Knockout of ATP2B3 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | ATP2B3 | response to chemicals | Melanoma Cell Line | Gene: ATP2B3 (ATPase plasma membrane Ca2+ transporting 3)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove biva... |
Does Knockout of ERC2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | ERC2 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: ERC2 (ELKS/RAB6-interacting/CAST family member 2)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the Rab3-interacting molecule (RIM)-binding protein family. Members of this protein family form part of the cytomatrix at the active zone (CAZ) complex and function as regula... |
Does Knockout of BAG5 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | BAG5 | cell proliferation | Renal Cancer Cell Line | Gene: BAG5 (BAG cochaperone 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein ki... |
Does Knockout of TANGO2 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | TANGO2 | cell proliferation | T-lymphoma cell line | Gene: TANGO2 (transport and golgi organization 2 homolog)
Type: protein-coding
Summary: This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells cau... |
Does Knockout of IFNE in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | IFNE | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: IFNE (interferon epsilon)
Type: protein-coding
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; defense response to other organism; and lymphocyte activation involved in immun... |
Does Knockout of AP1M1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | AP1M1 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: AP1M1 (adaptor related protein complex 1 subunit mu 1)
Type: protein-coding
Summary: The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small c... |
Does Activation of GLE1 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | GLE1 | response to virus | Hepatoma Cell Line | Gene: GLE1 (GLE1 RNA export mediator)
Type: protein-coding
Summary: This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L ... |
Does Knockout of DDX56 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | DDX56 | cell proliferation | Monocytic Leukemia Cell Line | Gene: DDX56 (DEAD-box helicase 56)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alterati... |
Does Knockout of MNAT1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | MNAT1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: MNAT1 (MNAT1 component of CDK activating kinase)
Type: protein-coding
Summary: The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to acti... |
Does Knockout of PKMYT1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | PKMYT1 | cell proliferation | Colonic Cancer Cell Line | Gene: PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphory... |
Does Knockout of AGAP6 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | AGAP6 | cell proliferation | Gastric Cancer Cell Line | Gene: AGAP6 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 6)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in regulation of catalytic activity. Predicted to be active in nucleus. [provided by Alliance of Ge... |
Does Knockout of SIRPA in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | SIRPA | response to virus | Hepatoma Cell Line | Gene: SIRPA (signal regulatory protein alpha)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be invol... |
Does Knockout of PFDN6 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | PFDN6 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: PFDN6 (prefoldin subunit 6)
Type: protein-coding
Summary: PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin conta... |
Does Knockout of RTN2 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | RTN2 | cell proliferation | Neuroblastoma Cell Line | Gene: RTN2 (reticulon 2)
Type: protein-coding
Summary: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Reticulon proteins also play an i... |
Does Knockout of KCNS2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | KCNS2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: KCNS2 (potassium voltage-gated channel modifier subfamily S member 2)
Type: protein-coding
Summary: Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of delayed rectifier potassium channel activity. Predic... |
Does Knockout of CNOT9 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | CNOT9 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: CNOT9 (CCR4-NOT transcription complex subunit 9)
Type: protein-coding
Summary: This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as ... |
Does Knockout of ITGAV in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | ITGAV | cell proliferation | Renal Cancer Cell Line | Gene: ITGAV (integrin subunit alpha V)
Type: protein-coding
Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encod... |
Does Knockout of PSMD4 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | PSMD4 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical s... |
Does Knockout of TARDBP in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | TARDBP | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: TARDBP (TAR DNA binding protein)
Type: protein-coding
Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is... |
Does Activation of COX7A2L in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | COX7A2L | protein/peptide accumulation | T cell | Gene: COX7A2L (cytochrome c oxidase subunit 7A2 like)
Type: protein-coding
Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 cata... |
Does Knockout of AK1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | AK1 | cell proliferation | Medulloblastoma Cell Line | Gene: AK1 (adenylate kinase 1)
Type: protein-coding
Summary: This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes.... |
Does Knockout of CCT5 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | CCT5 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: CCT5 (chaperonin containing TCP1 subunit 5)
Type: protein-coding
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, ea... |
Does Knockout of SRP19 in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | SRP19 | response to virus | Hepatoma Cell Line | Gene: SRP19 (signal recognition particle 19)
Type: protein-coding
Summary: Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal... |
Does Knockout of NPHP4 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | NPHP4 | cell proliferation | Melanoma Cell Line | Gene: NPHP4 (nephrocystin 4)
Type: protein-coding
Summary: This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this ge... |
Does Knockout of IFT74 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | IFT74 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: IFT74 (intraflagellar transport 74)
Type: protein-coding
Summary: This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as ... |
Does Knockout of FARP1 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | FARP1 | cell proliferation | Renal Cancer Cell Line | Gene: FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1)
Type: protein-coding
Summary: This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and ... |
Does Knockout of ELF2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | ELF2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ELF2 (E74 like ETS transcription factor 2)
Type: protein-coding
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of... |
Does Knockout of NXF5 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | NXF5 | response to virus | Huh-7 Cell | Gene: NXF5 (nuclear RNA export factor 5)
Type: pseudo
Summary: This gene is one member of a family of nuclear RNA export factor genes. Most transcript variants are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo. [provided by RefSeq, Sep 2022].
Gene Ontology: B... |
Does Knockout of AANAT in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | AANAT | cell proliferation | Astrocytoma Cell Line | Gene: AANAT (aralkylamine N-acetyltransferase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melato... |
Does Knockout of UBL5 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | UBL5 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: UBL5 (ubiquitin like 5)
Type: protein-coding
Summary: This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene pr... |
Does Knockout of MUC6 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | MUC6 | cell proliferation | Colonic Cancer Cell Line | Gene: MUC6 (mucin 6, oligomeric mucus/gel-forming (gene/pseudogene))
Type: protein-coding
Summary: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insolub... |
Does Activation of FGF5 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | FGF5 | protein/peptide accumulation | T cell | Gene: FGF5 (fibroblast growth factor 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embry... |
Does Knockout of PAICS in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | PAICS | cell proliferation | Melanoma Cell Line | Gene: PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase)
Type: protein-coding
Summary: This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole ... |
Does Knockout of CAPN3 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | CAPN3 | cell proliferation | T-lymphoma cell line | Gene: CAPN3 (calpain 3)
Type: protein-coding
Summary: Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically... |
Does Knockout of GNL2 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | GNL2 | cell proliferation | Astrocytoma Cell Line | Gene: GNL2 (G protein nucleolar 2)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in ribosome biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTP binding, GTPase activity, RNA binding, nucleotide bin... |
Does Knockout of SPC24 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | SPC24 | cell proliferation | Endometrial Cancer Cell Line | Gene: SPC24 (SPC24 component of NDC80 kinetochore complex)
Type: protein-coding
Summary: Predicted to be involved in cell division. Located in nucleolus and nucleoplasm. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: attachment of spindle microtub... |
Does Knockout of CEP120 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | CEP120 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: CEP120 (centrosomal protein 120)
Type: protein-coding
Summary: This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nu... |
Does Knockout of DSCR4 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | DSCR4 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: DSCR4 (Down syndrome critical region 4)
Type: ncRNA
Summary: The gene is found in a region of chromosome 21 that has been linked to the pathogenesis of Down syndrome. This gene is transcribed from a bi-directional promoter located in an endogenous retrovirus. [provided by RefSeq, Jan 2015].
... |
Does Knockout of PCID2 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | PCID2 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: PCID2 (PCI domain containing 2)
Type: protein-coding
Summary: This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoin... |
Does Knockout of PRPF40A in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | PRPF40A | cell proliferation | Gastric Cancer Cell Line | Gene: PRPF40A (pre-mRNA processing factor 40A)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in several processes, including cytoskeleton organization; regulation of cell shape; and regulation of cytokinesis. Located in nuclear matrix and nuclear speck. [provided by Alliance of Ge... |
Does Knockout of TECR in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | TECR | cell proliferation | Monocytic Leukemia Cell Line | Gene: TECR (trans-2,3-enoyl-CoA reductase)
Type: protein-coding
Summary: This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequenti... |
Does Knockout of ELAVL1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | ELAVL1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: ELAVL1 (ELAV like RNA binding protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. A... |
Does Knockout of CCNK in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | CCNK | cell proliferation | Colonic Cancer Cell Line | Gene: CCNK (cyclin K)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of ... |
Does Knockout of LYRM9 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | LYRM9 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: LYRM9 (LYR motif containing 9)
Type: protein-coding
Summary: Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A8MSI8
Entrez ID: 201229 |
Does Knockout of USP25 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | USP25 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: USP25 (ubiquitin specific peptidase 25)
Type: protein-coding
Summary: Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembl... |
Does Knockout of NRBP1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | NRBP1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: NRBP1 (nuclear receptor binding protein 1)
Type: protein-coding
Summary: Predicted to enable protein homodimerization activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. [provided by Alliance of Genome Resources, Apr 2022]
Gene ... |
Does Knockout of FLG2 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | FLG2 | cell proliferation | Astrocytoma Cell Line | Gene: FLG2 (filaggrin 2)
Type: protein-coding
Summary: The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associa... |
Does Knockout of MPZL1 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | MPZL1 | cell proliferation | Astrocytoma Cell Line | Gene: MPZL1 (myelin protein zero like 1)
Type: protein-coding
Summary: Predicted to enable structural molecule activity. Predicted to be involved in cell-cell signaling and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within positive regulation of cel... |
Does Knockout of NCAM1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | NCAM1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: NCAM1 (neural cell adhesion molecule 1)
Type: protein-coding
Summary: This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiati... |
Does Knockout of MDN1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | MDN1 | cell proliferation | Endometrial Cancer Cell Line | Gene: MDN1 (midasin AAA ATPase 1)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Involved in ribosomal large subunit assembly. Located in cytosol; intermediate filament cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: ... |
Does Knockout of TUBA1B in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | TUBA1B | cell proliferation | Melanoma Cell Line | Gene: TUBA1B (tubulin alpha 1b)
Type: protein-coding
Summary: Enables double-stranded RNA binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within cellular response to ... |
Does Knockout of DCTN2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | DCTN2 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: DCTN2 (dynactin subunit 2)
Type: protein-coding
Summary: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular... |
Does Knockout of HDAC3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | HDAC3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: HDAC3 (histone deacetylase 3)
Type: protein-coding
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encod... |
Does Activation of DGCR6L in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | DGCR6L | protein/peptide accumulation | T cell | Gene: DGCR6L (DiGeorge syndrome critical region gene 6 like)
Type: protein-coding
Summary: This gene, the result of a duplication at this locus, is one of two functional genes encoding nearly identical proteins that have similar expression patterns. The product of this gene is a protein that shares homo... |
Does Knockout of MST1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | MST1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: MST1 (macrophage stimulating 1)
Type: protein-coding
Summary: The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteo... |
Does Knockout of OR1A1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | OR1A1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: OR1A1 (olfactory receptor family 1 subfamily A member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of INPP5K in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | INPP5K | cell proliferation | Mammary Gland Tumor Cell Line | Gene: INPP5K (inositol polyphosphate-5-phosphatase K)
Type: protein-coding
Summary: This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate ... |
Does Knockout of RCOR1 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | RCOR1 | cell proliferation | Prostate Cancer Cell Line | Gene: RCOR1 (REST corepressor 1)
Type: protein-coding
Summary: This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transc... |
Does Knockout of PABPC1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | PABPC1 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PABPC1 (poly(A) binding protein cytoplasmic 1)
Type: protein-coding
Summary: This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.