prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of COA7 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
COA7
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: COA7 (cytochrome c oxidase assembly factor 7)
Type: protein-coding
Summary: Located in mitochondrial intermembrane space and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, protein-disulfide reductase activity; CC: mitochondrial intermembrane space, mitochondrion, nucleoplasm
Pathways: Thermogenesis - Homo sapiens (human)
UniProt: Q96BR5
Entrez ID: 65260
|
Does Knockout of MRPS23 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
MRPS23
|
cell proliferation
|
T-lymphoma cell line
|
Gene: MRPS23 (mitochondrial ribosomal protein S23)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, nuclear membrane, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q9Y3D9
Entrez ID: 51649
|
Does Knockout of SH2D3C in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
SH2D3C
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: SH2D3C (SH2 domain containing 3C)
Type: protein-coding
Summary: This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: JNK cascade, small GTPase-mediated signal transduction; MF: guanyl-nucleotide exchange factor activity, phosphotyrosine residue binding, protein binding; CC: axon, cell projection, cytoplasm, cytosol, membrane, plasma membrane, ruffle membrane
Pathways: TCR
UniProt: Q8N5H7
Entrez ID: 10044
|
Does Knockout of ZIC5 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
ZIC5
|
cell proliferation
|
Cancer Cell Line
|
Gene: ZIC5 (Zic family zinc finger 5)
Type: protein-coding
Summary: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. The encoded protein may act as a transcriptional repressor. Studies in mouse and Xenopus support a role for this gene in neural crest development. Elevated expression of this gene has been observed in various human cancers and may contribute to cancer progression. This gene is closely linked to a related family member on chromosome 13. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: cell differentiation, central nervous system development, nervous system development, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Mesodermal commitment pathway, Neural Crest Differentiation
UniProt: Q96T25
Entrez ID: 85416
|
Does Knockout of POLD1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
POLD1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: POLD1 (DNA polymerase delta 1, catalytic subunit)
Type: protein-coding
Summary: This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA replication proofreading, DNA synthesis involved in DNA repair, DNA-templated DNA replication, base-excision repair, gap-filling, cellular response to UV, error-free translesion synthesis, fatty acid homeostasis, nucleotide-excision repair, DNA gap filling, response to UV; MF: 3'-5' exonuclease activity, 3'-5'-DNA exonuclease activity, 4 iron, 4 sulfur cluster binding, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, chromatin binding, damaged DNA binding, enzyme binding, exonuclease activity, hydrolase activity, iron-sulfur cluster binding, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: aggresome, chromosome, telomeric region, cytosol, delta DNA polymerase complex, membrane, nucleoplasm, nucleotide-excision repair complex, nucleus
Pathways: Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, Cytosolic iron-sulfur cluster assembly, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Metabolism, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), Nucleotide metabolism, PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Pyrimidine metabolism, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P28340
Entrez ID: 5424
|
Does Knockout of PSME2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
PSME2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PSME2 (proteasome activator subunit 2)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: regulation of G1/S transition of mitotic cell cycle, regulation of proteasomal protein catabolic process; MF: endopeptidase activator activity, identical protein binding, protein binding; CC: cytoplasm, cytosol, extracellular exosome, membrane, nucleoplasm, proteasome activator complex, proteasome complex
Pathways: Adaptive Immune System, Antigen processing and presentation - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Class I MHC mediated antigen processing & presentation, Cross-presentation of soluble exogenous antigens (endosomes), Cytokine Signaling in Immune system, ER-Phagosome pathway, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Immune System, Interleukin-12 family signaling, Interleukin-12 signaling, Metabolism of proteins, Post-translational protein modification, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, Signaling by Interleukins
UniProt: Q9UL46
Entrez ID: 5721
|
Does Knockout of EIF2B1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
EIF2B1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha)
Type: protein-coding
Summary: This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: T cell receptor signaling pathway, cytoplasmic translational initiation, oligodendrocyte development, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, identical protein binding, protein binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex, membrane, plasma membrane
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Translation, Translation Factors
UniProt: Q14232
Entrez ID: 1967
|
Does Knockout of NAA20 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
NAA20
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: NAA20 (N-alpha-acetyltransferase 20, NatB catalytic subunit)
Type: protein-coding
Summary: NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009].
Gene Ontology: BP: N-terminal peptidyl-aspartic acid acetylation, N-terminal peptidyl-glutamic acid acetylation, N-terminal peptidyl-glutamine acetylation, N-terminal protein amino acid acetylation, regulation of actin cytoskeleton organization; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, protein N-terminal-methionine acetyltransferase activity, protein binding, protein-N-terminal amino-acid acetyltransferase activity, transferase activity; CC: NatB complex, cytoplasm, cytosol, nucleus
Pathways: Metapathway biotransformation Phase I and II
UniProt: P61599
Entrez ID: 51126
|
Does Knockout of YBEY in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
YBEY
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: YBEY (ybeY metalloendoribonuclease)
Type: protein-coding
Summary: This gene encodes a highly conserved metalloprotein. A similar protein in bacteria acts as an endoribonuclease, and is thought to function in ribosomal RNA maturation and ribosome assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: MF: RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, nuclease activity, protein binding; CC: mitochondrion, nucleus
Pathways:
UniProt: P58557
Entrez ID: 54059
|
Does Knockout of KCNS2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
KCNS2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: KCNS2 (potassium voltage-gated channel modifier subfamily S member 2)
Type: protein-coding
Summary: Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of delayed rectifier potassium channel activity. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of potassium ion transmembrane transport, transmembrane transport; MF: monoatomic ion channel activity, potassium channel activity, potassium channel regulator activity, protein binding, voltage-gated potassium channel activity; CC: cytoplasm, membrane, monoatomic ion channel complex, perinuclear region of cytoplasm, plasma membrane, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: Q9ULS6
Entrez ID: 3788
|
Does Knockout of CASC3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
CASC3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CASC3 (CASC3 exon junction complex subunit)
Type: protein-coding
Summary: The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, intracellular mRNA localization, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translation; MF: RNA binding, enzyme binding, identical protein binding, mRNA binding, protein binding, ubiquitin protein ligase binding; CC: U2-type catalytic step 1 spliceosome, cell projection, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, dendrite, exon-exon junction complex, nuclear membrane, nuclear speck, nucleoplasm, nucleus, perinuclear region of cytoplasm, ribonucleoprotein complex, spliceosomal complex
Pathways: Axon guidance, Developmental Biology, Gene expression (Transcription), Metabolism of RNA, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, RNA transport - Homo sapiens (human), Regulation of expression of SLITs and ROBOs, Signaling by ROBO receptors, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Homo sapiens (human)
UniProt: O15234
Entrez ID: 22794
|
Does Knockout of MRPL33 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
MRPL33
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: MRPL33 (mitochondrial ribosomal protein L33)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; CC: cytoplasm, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: O75394
Entrez ID: 9553
|
Does Knockout of TTC16 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
TTC16
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: TTC16 (tetratricopeptide repeat domain 16)
Type: protein-coding
Summary: tetratricopeptide repeat domain 16
Gene Ontology:
Pathways:
UniProt: Q8NEE8
Entrez ID: 158248
|
Does Knockout of AMPD1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
AMPD1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: AMPD1 (adenosine monophosphate deaminase 1)
Type: protein-coding
Summary: Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010].
Gene Ontology: BP: AMP metabolic process, GMP salvage, IMP biosynthetic process, IMP salvage, nucleoside phosphate metabolic process, nucleotide metabolic process, purine ribonucleoside monophosphate biosynthetic process; MF: AMP deaminase activity, deaminase activity, hydrolase activity, identical protein binding, metal ion binding, protein binding; CC: cytosol
Pathways: AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Gout or Kelley-Seegmiller Syndrome, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide salvage, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Purine salvage, Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II
UniProt: P23109
Entrez ID: 270
|
Does Knockout of HNRNPC in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
HNRNPC
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: HNRNPC (heterogeneous nuclear ribonucleoprotein C)
Type: protein-coding
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, RNA splicing, chromatin remodeling, mRNA processing, mRNA splicing, via spliceosome, negative regulation of telomere maintenance via telomerase, osteoblast differentiation; MF: N6-methyladenosine-containing RNA reader activity, RNA binding, identical protein binding, mRNA 3'-UTR binding, nucleic acid binding, nucleosomal DNA binding, poly(U) RNA binding, protein binding, telomerase RNA binding; CC: actin cytoskeleton, catalytic step 2 spliceosome, chromatin, cytosol, extracellular exosome, extracellular region, membrane, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, spliceosomal complex, telomerase holoenzyme complex
Pathways: Regulation of Telomerase, Spliceosome - Homo sapiens (human), mRNA Processing
UniProt: P07910
Entrez ID: 3183
|
Does Knockout of DAGLB in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
DAGLB
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DAGLB (diacylglycerol lipase beta)
Type: protein-coding
Summary: Enables lipase activity. Involved in arachidonic acid metabolic process. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: arachidonate metabolic process, cannabinoid biosynthetic process, diacylglycerol catabolic process, icosanoid metabolic process, lipid catabolic process, lipid metabolic process, monoacylglycerol biosynthetic process, neuroblast proliferation, neurogenesis, positive regulation of triglyceride catabolic process, prostaglandin biosynthetic process, regulation of inflammatory response; MF: hydrolase activity, lipase activity, metal ion binding, monoacylglycerol lipase activity, protein binding, triacylglycerol lipase activity; CC: lysosomal membrane, membrane, nucleoplasm, plasma membrane
Pathways: Aldosterone synthesis and secretion - Homo sapiens (human), Arachidonate production from DAG, Cannabinoid receptor signaling, Effects of PIP2 hydrolysis, G alpha (q) signalling events, GPCR downstream signalling, Hemostasis, N-cadherin signaling events, Platelet activation, signaling and aggregation, Retrograde endocannabinoid signaling - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q8NCG7
Entrez ID: 221955
|
Does Knockout of SERTAD3 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
SERTAD3
|
response to virus
|
Hepatoma Cell Line
|
Gene: SERTAD3 (SERTA domain containing 3)
Type: protein-coding
Summary: The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: negative regulation of cell growth, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription; CC: nucleus
Pathways:
UniProt: Q9UJW9
Entrez ID: 29946
|
Does Knockout of RPH3AL in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
RPH3AL
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: RPH3AL (rabphilin 3A like (without C2 domains))
Type: protein-coding
Summary: The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium-dependent activation of synaptic vesicle fusion, exocytosis, glucose homeostasis, intracellular protein transport, negative regulation of G protein-coupled receptor signaling pathway, positive regulation of calcium ion-dependent exocytosis, positive regulation of insulin secretion, regulation of calcium ion-dependent exocytosis; MF: cytoskeletal protein binding, metal ion binding, protein binding, small GTPase binding, zinc ion binding; CC: cytoplasm, cytoplasmic vesicle, membrane, presynapse, synapse, transport vesicle membrane
Pathways: Deregulation of Rab and Rab Effector Genes in Bladder Cancer
UniProt: Q9UNE2
Entrez ID: 9501
|
Does Knockout of ARHGEF7 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
ARHGEF7
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: ARHGEF7 (Rho guanine nucleotide exchange factor 7)
Type: protein-coding
Summary: This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: Golgi organization, Rho protein signal transduction, ephrin receptor signaling pathway, focal adhesion assembly, intracellular signal transduction, lamellipodium assembly, negative regulation of microtubule nucleation, nervous system development, positive regulation of GTPase activity, positive regulation of apoptotic process, positive regulation of fibroblast migration, positive regulation of lamellipodium morphogenesis, positive regulation of substrate adhesion-dependent cell spreading, signal transduction; MF: gamma-tubulin binding, guanyl-nucleotide exchange factor activity, protein binding, protein kinase binding; CC: anchoring junction, cell cortex, cell projection, centrosome, cytoplasm, cytosol, focal adhesion, lamellipodium, mitotic spindle pole, neuron projection, neuronal cell body, postsynapse, protein-containing complex, ruffle
Pathways: Activation of NMDA receptors and postsynaptic events, Activation of RAC1 downstream of NMDARs, Aurora A signaling, CAMKK2 Pathway, CDC42 signaling events, EGFR1, Integrin-linked kinase signaling, Integrin-mediated Cell Adhesion, Internalization of ErbB1, Intracellular Signalling Through Adenosine Receptor A2a and Adenosine, Intracellular Signalling Through Adenosine Receptor A2b and Adenosine, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Post NMDA receptor activation events, Regulation of Actin Cytoskeleton, Regulation of CDC42 activity, Regulation of RAC1 activity, Regulation of actin cytoskeleton - Homo sapiens (human), Signaling events mediated by focal adhesion kinase, TCR, Transmission across Chemical Synapses, Yersinia infection - Homo sapiens (human), agrin in postsynaptic differentiation
UniProt: Q14155
Entrez ID: 8874
|
Does Activation of HSPA12B in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
HSPA12B
|
protein/peptide accumulation
|
T cell
|
Gene: HSPA12B (heat shock protein family A (Hsp70) member 12B)
Type: protein-coding
Summary: The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: angiogenesis, endothelial cell migration; MF: ATP binding, nucleotide binding, protein binding
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: Q96MM6
Entrez ID: 116835
|
Does Knockout of CRLS1 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
CRLS1
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: CRLS1 (cardiolipin synthase 1)
Type: protein-coding
Summary: This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitochondrial function. [provided by RefSeq, Apr 2016].
Gene Ontology: BP: cardiolipin biosynthetic process, glycerophospholipid biosynthetic process, lipid metabolic process, phosphatidylglycerol acyl-chain remodeling, phospholipid biosynthetic process; MF: 1-acylglycerol-3-phosphate O-acyltransferase activity, 2-acylglycerol-3-phosphate O-acyltransferase activity, cardiolipin synthase (CMP-forming), phosphotransferase activity, for other substituted phosphate groups, transferase activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways: Acyl chain remodelling of PG, Glycerolipids and Glycerophospholipids, Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, Phospholipid Biosynthesis, Phospholipid metabolism, Synthesis of CL, cardiolipin biosynthesis
UniProt: Q9UJA2
Entrez ID: 54675
|
Does Knockout of EIF1AX in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
EIF1AX
|
cell proliferation
|
Cancer Cell Line
|
Gene: EIF1AX (eukaryotic translation initiation factor 1A X-linked)
Type: protein-coding
Summary: This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ribosome assembly, translation, translational initiation; MF: RNA binding, protein binding, tRNA binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, multi-eIF complex, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, eukaryotic protein translation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: P47813
Entrez ID: 1964
|
Does Knockout of NCL in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
NCL
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: NCL (nucleolin)
Type: protein-coding
Summary: Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: angiogenesis, cellular response to epidermal growth factor stimulus, cellular response to leukemia inhibitory factor, negative regulation of insulin receptor signaling pathway, negative regulation of translation, positive regulation of mRNA splicing, via spliceosome, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, regulation of RNA metabolic process, regulation of gene expression; MF: DNA binding, DNA topoisomerase binding, PH domain binding, RNA binding, identical protein binding, insulin receptor substrate binding, mRNA 5'-UTR binding, nucleic acid binding, protein binding, telomeric DNA binding; CC: cell cortex, chromosome, cornified envelope, cytoplasm, cytoplasmic ribonucleoprotein granule, extracellular exosome, macropinosome membrane, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane, ribonucleoprotein complex, spliceosomal complex
Pathways: Aurora B signaling, Disease, Infectious disease, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Regulation of Telomerase, Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) attachment and entry, TCR, Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling, VEGFA-VEGFR2 Signaling Pathway, Validated targets of C-MYC transcriptional activation, Viral Infection Pathways, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P19338
Entrez ID: 4691
|
Does Knockout of PAPSS1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
PAPSS1
|
cell proliferation
|
Cancer Cell Line
|
Gene: PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1)
Type: protein-coding
Summary: Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process, skeletal system development, sulfate assimilation; MF: ATP binding, adenylylsulfate kinase activity, catalytic activity, kinase activity, nucleotide binding, nucleotidyltransferase activity, protein binding, protein homodimerization activity, sulfate adenylyltransferase (ATP) activity, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Disease, Diseases of signal transduction by growth factor receptors and second messengers, Glycosaminoglycan metabolism, Metabolism, Metabolism of amino acids and derivatives, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of ingested H2SeO4 and H2SeO3 into H2Se, Oncogenic MAPK signaling, Purine metabolism - Homo sapiens (human), Selenoamino Acid Metabolism, Selenoamino acid metabolism, Selenocompound metabolism - Homo sapiens (human), Signaling by BRAF and RAF1 fusions, Sulfation Biotransformation Reaction, Sulfur metabolism - Homo sapiens (human), Transport and metabolism of PAPS, sulfate activation for sulfonation
UniProt: O43252
Entrez ID: 9061
|
Does Knockout of PSMA4 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
PSMA4
|
cell proliferation
|
Cancer Cell Line
|
Gene: PSMA4 (proteasome 20S subunit alpha 4)
Type: protein-coding
Summary: This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; CC: P-body, cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Exercise-induced Circadian Regulation, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: P25789
Entrez ID: 5685
|
Does Knockout of BTBD9 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
BTBD9
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: BTBD9 (BTB domain containing 9)
Type: protein-coding
Summary: This locus encodes a BTB/POZ domain-containing protein. This domain is known to be involved in protein-protein interactions. Polymorphisms at this locus have been reported to be associated with susceptibility to Restless Legs Syndrome and may also be associated with Tourette Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: adult locomotory behavior, circadian behavior, circadian sleep/wake cycle, non-REM sleep, long-term memory, modulation of chemical synaptic transmission, multicellular organismal-level iron ion homeostasis, regulation of synaptic vesicle endocytosis, sensory perception of temperature stimulus, serotonin metabolic process; CC: cytoplasm, glutamatergic synapse
Pathways:
UniProt: Q96Q07
Entrez ID: 114781
|
Does Knockout of SLU7 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
SLU7
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SLU7 (spliceosome associated SLU7)
Type: protein-coding
Summary: Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, alternative mRNA splicing, via spliceosome, cellular response to heat, intracellular protein transport, mRNA 3'-splice site recognition, mRNA processing, mRNA splicing, via spliceosome; MF: metal ion binding, pre-mRNA 3'-splice site binding, protein binding, second spliceosomal transesterification activity, zinc ion binding; CC: catalytic step 2 spliceosome, cytoplasm, cytosol, membrane, nuclear speck, nucleoplasm, nucleus, small nuclear ribonucleoprotein complex, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O95391
Entrez ID: 10569
|
Does Activation of DUSP3 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
DUSP3
|
protein/peptide accumulation
|
T cell
|
Gene: DUSP3 (dual specificity phosphatase 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to epidermal growth factor stimulus, dephosphorylation, negative regulation of ERK1 and ERK2 cascade, negative regulation of JNK cascade, negative regulation of MAPK cascade, negative regulation of T cell activation, negative regulation of T cell receptor signaling pathway, negative regulation of cell migration, negative regulation of chemotaxis, negative regulation of epidermal growth factor receptor signaling pathway, negative regulation of signal transduction, peptidyl-tyrosine dephosphorylation, positive regulation of focal adhesion disassembly, positive regulation of mitotic cell cycle, regulation of focal adhesion assembly; MF: MAP kinase phosphatase activity, cytoskeletal protein binding, hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein kinase binding, protein serine/threonine phosphatase activity, protein tyrosine kinase binding, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, receptor signaling protein tyrosine kinase inhibitor activity, receptor tyrosine kinase binding; CC: cell projection, cilium, cytoplasm, cytoskeleton, cytosol, immunological synapse, motile cilium, nucleoplasm, nucleus
Pathways: Cytokine Signaling in Immune system, ERK/MAPK targets, ERKs are inactivated, Fragile X Syndrome, Immune System, Innate Immune System, Interleukin-17 signaling, MAP kinase activation, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), MAPK targets/ Nuclear events mediated by MAP kinases, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Nuclear Events (kinase and transcription factor activation), Signal Transduction, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, TCR, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades
UniProt: P51452
Entrez ID: 1845
|
Does Knockout of RPL38 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
RPL38
|
cell proliferation
|
Cancer Cell Line
|
Gene: RPL38 (ribosomal protein L38)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 90S preribosome assembly, axial mesoderm development, cytoplasmic translation, middle ear morphogenesis, ossification, protein-RNA complex assembly, regulation of translation, sensory perception of sound, skeletal system development, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, eukaryotic 80S initiation complex, focal adhesion, postsynaptic density, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Mesodermal commitment pathway, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P63173
Entrez ID: 6169
|
Does Knockout of ACP6 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
ACP6
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: ACP6 (acid phosphatase 6, lysophosphatidic)
Type: protein-coding
Summary: This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016].
Gene Ontology: BP: hematopoietic progenitor cell differentiation, lipid metabolic process, lysobisphosphatidic acid metabolic process, phosphatidic acid biosynthetic process, phospholipid metabolic process; MF: acid phosphatase activity, hydrolase activity, lysophosphatidic acid phosphatase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: 1q21.1 copy number variation syndrome, Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA
UniProt: Q9NPH0
Entrez ID: 51205
|
Does Knockout of NUP98 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
NUP98
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: NUP98 (nucleoporin 98 and 96 precursor)
Type: protein-coding
Summary: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: RNA export from nucleus, mRNA transport, nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, positive regulation of mRNA splicing, via spliceosome, post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery, protein import into nucleus, protein transport, proteolysis, telomere tethering at nuclear periphery; MF: RNA binding, hydrolase activity, mRNA binding, molecular condensate scaffold activity, nuclear localization sequence binding, peptidase activity, peptide binding, promoter-specific chromatin binding, protein binding, serine-type peptidase activity, structural constituent of nuclear pore, transcription coactivator activity; CC: cytosol, kinetochore, membrane, nuclear body, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore cytoplasmic filaments, nuclear pore nuclear basket, nuclear pore outer ring, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Influenza A - Homo sapiens (human), RNA transport - Homo sapiens (human), SARS-CoV-2 innate immunity evasion and cell-specific immune response
UniProt: P52948
Entrez ID: 4928
|
Does Knockout of BRD8 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
BRD8
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: BRD8 (bromodomain containing 8)
Type: protein-coding
Summary: The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: cell surface receptor signaling pathway, cellular response to thyroid hormone stimulus, chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, positive regulation of transcription by RNA polymerase II, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair; MF: nuclear thyroid hormone receptor binding, protein binding, transcription coactivator activity; CC: NuA4 histone acetyltransferase complex, Swr1 complex, mitochondrion, nucleoplasm, nucleosome, nucleus
Pathways:
UniProt: Q9H0E9
Entrez ID: 10902
|
Does Knockout of CEACAM16 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
CEACAM16
|
cell proliferation
|
Cancer Cell Line
|
Gene: CEACAM16 (CEA cell adhesion molecule 16, tectorial membrane component)
Type: protein-coding
Summary: The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012].
Gene Ontology: BP: sensory perception of sound; CC: extracellular region, extracellular space, stereocilium tip
Pathways:
UniProt: Q2WEN9
Entrez ID: 388551
|
Does Knockout of MYO1H in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
MYO1H
|
cell proliferation
|
Bladder Carcinoma
|
Gene: MYO1H (myosin IH)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; microvillus; and vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin filament organization, actin filament-based movement, endocytosis; MF: ATP binding, actin binding, actin filament binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding; CC: actin cytoskeleton, actin filament, cytoplasm, microvillus, myosin complex, plasma membrane
Pathways: Pathogenic Escherichia coli infection - Homo sapiens (human)
UniProt: A0A140TA25, B4DNW6, S4R387
Entrez ID: 283446
|
Does Knockout of DHX8 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
DHX8
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: DHX8 (DEAH-box helicase 8)
Type: protein-coding
Summary: This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on RNA, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, identical protein binding, nucleic acid binding, nucleotide binding, protein binding; CC: U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, cytosol, nuclear body, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q14562
Entrez ID: 1659
|
Does Knockout of ARL9 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
ARL9
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ARL9 (ARF like GTPase 9)
Type: protein-coding
Summary: ARL9 is a member of the small GTPase protein family with a high degree of similarity to ARF (MIM 103180) proteins of the RAS superfamily.[supplied by OMIM, Nov 2008].
Gene Ontology: MF: GTP binding, GTPase activity, nucleotide binding
Pathways:
UniProt: Q6T311
Entrez ID: 132946
|
Does Knockout of SMC4 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
SMC4
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: SMC4 (structural maintenance of chromosomes 4)
Type: protein-coding
Summary: This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016].
Gene Ontology: BP: cell division, chromosome condensation, chromosome organization, kinetochore organization, meiotic chromosome condensation, meiotic chromosome segregation, mitotic chromosome condensation, mitotic sister chromatid segregation, nuclear chromosome segregation, nuclear division, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation; MF: ATP binding, ATP hydrolysis activity, chromatin binding, nucleotide binding, protein binding, single-stranded DNA binding; CC: chromosome, chromosome, centromeric region, condensed nuclear chromosome, condensin complex, cytoplasm, cytosol, nuclear lumen, nuclear speck, nucleoplasm, nucleus
Pathways: Aurora B signaling, Cell Cycle, Cell Cycle, Mitotic, Ciliary landscape, Condensation of Prometaphase Chromosomes, Condensation of Prophase Chromosomes, M Phase, Mitotic Prometaphase, Mitotic Prophase
UniProt: Q9NTJ3
Entrez ID: 10051
|
Does Knockout of DCAF6 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
DCAF6
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: DCAF6 (DDB1 and CUL4 associated factor 6)
Type: protein-coding
Summary: The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, protein ubiquitination; MF: protein binding, transcription coactivator activity; CC: Cul4-RING E3 ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q58WW2
Entrez ID: 55827
|
Does Knockout of RPE65 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
RPE65
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: RPE65 (retinoid isomerohydrolase RPE65)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. [provided by RefSeq, Oct 2017].
Gene Ontology: BP: camera-type eye development, circadian rhythm, detection of light stimulus involved in visual perception, lipid metabolic process, neural retina development, response to light stimulus, retina homeostasis, retinal metabolic process, retinoid metabolic process, retinol metabolic process, visual perception, vitamin A metabolic process, zeaxanthin biosynthetic process; MF: all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity, all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity, beta-carotene 15,15'-dioxygenase activity, cardiolipin binding, hydrolase activity, isomerase activity, metal ion binding, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, phosphatidylcholine binding, phosphatidylserine binding, protein binding, retinol isomerase activity; CC: cell body, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus, plasma membrane
Pathways: Retinol Metabolism, Retinol metabolism - Homo sapiens (human), Sensory Perception, The canonical retinoid cycle in rods (twilight vision), Visual phototransduction, Visual signal transduction: Cones, Visual signal transduction: Rods, Vitamin A Deficiency, Vitamin A and carotenoid metabolism, the visual cycle I (vertebrates)
UniProt: Q16518
Entrez ID: 6121
|
Does Knockout of PSMD7 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
PSMD7
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: PSMD7 (proteasome 26S subunit, non-ATPase 7)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process; MF: metal-dependent deubiquitinase activity, peptidase activity, protein binding, protein homodimerization activity; CC: cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, nucleoplasm, nucleus, proteasome complex, proteasome regulatory particle, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: P51665
Entrez ID: 5713
|
Does Knockout of NOCT in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
NOCT
|
cell proliferation
|
T-lymphoma cell line
|
Gene: NOCT (nocturnin)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: NADP+ metabolic process, P-body assembly, circadian regulation of gene expression, circadian rhythm, deadenylation-dependent decapping of nuclear-transcribed mRNA, mRNA stabilization, negative regulation of gene expression, negative regulation of osteoblast differentiation, nucleobase-containing compound metabolic process, positive regulation of fat cell differentiation, regulation of circadian rhythm, regulation of embryonic development, response to lipopolysaccharide, rhythmic process, transcription by RNA polymerase II; MF: 3'-5'-RNA exonuclease activity, NADP phosphatase activity, NADPH phosphatase activity, RNA binding, catalytic activity, hydrolase activity, hydrolase activity, acting on ester bonds, mRNA binding, metal ion binding, poly(A)-specific ribonuclease activity, protein binding; CC: P-body, cytoplasm, mitochondrion, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: BMAL1:CLOCK,NPAS2 activates circadian expression, Circadian clock
UniProt: Q9UK39
Entrez ID: 25819
|
Does Knockout of ATP2B3 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
ATP2B3
|
response to chemicals
|
Melanoma Cell Line
|
Gene: ATP2B3 (ATPase plasma membrane Ca2+ transporting 3)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion export across plasma membrane, calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of cardiac conduction, regulation of cytosolic calcium ion concentration, regulation of presynaptic cytosolic calcium ion concentration; MF: ATP binding, ATP hydrolysis activity, P-type calcium transporter activity, P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration, calcium ion transmembrane transporter activity, calmodulin binding, metal ion binding, nucleotide binding, protein binding; CC: GABA-ergic synapse, cell projection, extracellular vesicle, glutamatergic synapse, intracellular membrane-bounded organelle, membrane, parallel fiber, parallel fiber to Purkinje cell synapse, plasma membrane, presynaptic membrane, synapse
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Cardiac conduction, Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), Hemostasis, Ion channel transport, Ion homeostasis, Ion transport by P-type ATPases, Mineral absorption - Homo sapiens (human), Muscle contraction, Pancreatic secretion - Homo sapiens (human), Platelet calcium homeostasis, Platelet homeostasis, Reduction of cytosolic Ca++ levels, Salivary secretion - Homo sapiens (human), Transport of small molecules, Vitamin D-sensitive calcium signaling in depression, cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: Q16720
Entrez ID: 492
|
Does Knockout of ERC2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
ERC2
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: ERC2 (ELKS/RAB6-interacting/CAST family member 2)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the Rab3-interacting molecule (RIM)-binding protein family. Members of this protein family form part of the cytomatrix at the active zone (CAZ) complex and function as regulators of neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: maintenance of presynaptic active zone structure, regulation of calcium-dependent activation of synaptic vesicle fusion, regulation of presynaptic cytosolic calcium ion concentration, synaptic vesicle priming; MF: protein binding, structural constituent of presynaptic active zone; CC: GABA-ergic synapse, cell projection, cytoplasm, cytoskeleton, glutamatergic synapse, growth cone, presynapse, presynaptic active zone, presynaptic active zone cytoplasmic component, presynaptic membrane, synapse
Pathways: Exercise-induced Circadian Regulation
UniProt: O15083
Entrez ID: 26059
|
Does Knockout of BAG5 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
BAG5
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: BAG5 (BAG cochaperone 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi organization, negative regulation of neuron projection development, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of protein refolding, negative regulation of protein ubiquitination, protein folding, protein stabilization, regulation of inclusion body assembly; MF: adenyl-nucleotide exchange factor activity, protein binding, protein kinase binding, protein-folding chaperone binding, ubiquitin ligase inhibitor activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, inclusion body, junctional membrane complex, membrane, mitochondrion, nucleus, perinuclear region of cytoplasm
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: Q9UL15
Entrez ID: 9529
|
Does Knockout of TANGO2 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
TANGO2
|
cell proliferation
|
T-lymphoma cell line
|
Gene: TANGO2 (transport and golgi organization 2 homolog)
Type: protein-coding
Summary: This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016].
Gene Ontology: BP: Golgi organization, protein secretion; CC: Golgi apparatus, cytoplasm, cytosol, mitochondrion
Pathways: 22q11.2 copy number variation syndrome
UniProt: Q6ICL3
Entrez ID: 128989
|
Does Knockout of IFNE in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
IFNE
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: IFNE (interferon epsilon)
Type: protein-coding
Summary: Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; defense response to other organism; and lymphocyte activation involved in immune response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: B cell activation involved in immune response, T cell activation involved in immune response, adaptive immune response, cellular response to virus, defense response, defense response to bacterium, defense response to virus, humoral immune response, natural killer cell activation involved in immune response, response to exogenous dsRNA, type I interferon-mediated signaling pathway; MF: cytokine activity, cytokine receptor binding, type I interferon receptor binding; CC: extracellular region, extracellular space
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human), JAK-STAT signaling pathway - Homo sapiens (human), Novel intracellular components of RIG-I-like receptor (RLR) pathway, Overview of interferons-mediated signaling pathway, RIG-I-like receptor signaling pathway - Homo sapiens (human)
UniProt: Q86WN2
Entrez ID: 338376
|
Does Knockout of AP1M1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
AP1M1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: AP1M1 (adaptor related protein complex 1 subunit mu 1)
Type: protein-coding
Summary: The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: endosome to melanosome transport, intracellular protein transport, melanosome assembly, melanosome organization, platelet dense granule organization, protein transport, vesicle-mediated transport; MF: clathrin adaptor activity, protein binding; CC: AP-1 adaptor complex, Golgi apparatus, Golgi membrane, clathrin adaptor complex, clathrin-coated vesicle, clathrin-coated vesicle membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, early endosome, extracellular exosome, lysosomal membrane, membrane, plasma membrane, specific granule membrane, synapse, trans-Golgi network membrane
Pathways: Adaptive Immune System, Disease, E-cadherin signaling in the nascent adherens junction, Golgi Associated Vesicle Biogenesis, HIV Infection, Host Interactions of HIV factors, Human immunodeficiency virus 1 infection - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Lysosome - Homo sapiens (human), Lysosome Vesicle Biogenesis, MHC class II antigen presentation, Membrane Trafficking, Nef mediated downregulation of MHC class I complex cell surface expression, Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, Neutrophil degranulation, The role of Nef in HIV-1 replication and disease pathogenesis, Vesicle-mediated transport, Viral Infection Pathways, trans-Golgi Network Vesicle Budding
UniProt: Q9BXS5
Entrez ID: 8907
|
Does Activation of GLE1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
GLE1
|
response to virus
|
Hepatoma Cell Line
|
Gene: GLE1 (GLE1 RNA export mediator)
Type: protein-coding
Summary: This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, poly(A)+ mRNA export from nucleus, protein transport; MF: identical protein binding, inositol hexakisphosphate binding, phospholipid binding, protein binding, translation initiation factor binding; CC: centriole, centrosome, ciliary basal body, cytoplasm, cytosol, extracellular space, membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore cytoplasmic filaments, nucleolus, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q53GS7
Entrez ID: 2733
|
Does Knockout of DDX56 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
DDX56
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DDX56 (DEAD-box helicase 56)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: cytoplasmic pattern recognition receptor signaling pathway, defense response to virus, host-mediated perturbation of viral RNA genome replication, negative regulation of type I interferon production, positive regulation of neuron projection development, protein import into nucleus, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA stem-loop binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding, protein sequestering activity; CC: cytosol, membrane, nucleolus, nucleus
Pathways:
UniProt: Q9NY93
Entrez ID: 54606
|
Does Knockout of MNAT1 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
MNAT1
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: MNAT1 (MNAT1 component of CDK activating kinase)
Type: protein-coding
Summary: The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: DNA repair, G1/S transition of mitotic cell cycle, adult heart development, negative regulation of apoptotic process, nucleotide-excision repair, positive regulation of smooth muscle cell proliferation, regulation of DNA-templated transcription, regulation of G1/S transition of mitotic cell cycle, regulation of transcription by RNA polymerase II, response to calcium ion, transcription initiation at RNA polymerase II promoter, ventricular system development; MF: cyclin-dependent protein serine/threonine kinase activator activity, metal ion binding, protein binding, zinc ion binding; CC: CAK-ERCC2 complex, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, nucleus, transcription factor TFIIH core complex, transcription factor TFIIH holo complex, transcription factor TFIIK complex
Pathways: AndrogenReceptor, Basal transcription factors - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA Repair, DNA Repair Pathways Full Network, Disease, Dual incision in TC-NER, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, G1 Phase, G1 to S cell cycle control, G1/S Transition, G2/M Transition, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Retinoic acid receptors-mediated signaling, S Phase, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, Viral Infection Pathways, mRNA Capping, sonic hedgehog receptor ptc1 regulates cell cycle
UniProt: P51948
Entrez ID: 4331
|
Does Knockout of PKMYT1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
PKMYT1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1)
Type: protein-coding
Summary: This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, meiotic cell cycle, mitotic cell cycle, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of G2/MI transition of meiotic cell cycle, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of mitotic nuclear division; MF: ATP binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Cell cycle, Cell cycle - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human)
UniProt: Q99640
Entrez ID: 9088
|
Does Knockout of AGAP6 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
AGAP6
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: AGAP6 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 6)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in regulation of catalytic activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase activator activity, GTPase activity, metal ion binding, zinc ion binding
Pathways: Endocytosis - Homo sapiens (human)
UniProt: Q5VW22
Entrez ID: 414189
|
Does Knockout of SIRPA in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
SIRPA
|
response to virus
|
Hepatoma Cell Line
|
Gene: SIRPA (signal regulatory protein alpha)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, cell migration, cell-cell adhesion, cellular response to hydrogen peroxide, cellular response to interleukin-1, cellular response to interleukin-12, cellular response to type II interferon, heterotypic cell-cell adhesion, monocyte extravasation, negative regulation of ERK1 and ERK2 cascade, negative regulation of JNK cascade, negative regulation of canonical NF-kappaB signal transduction, negative regulation of chemokine (C-C motif) ligand 5 production, negative regulation of cytokine production involved in inflammatory response, negative regulation of inflammatory response, negative regulation of interferon-beta production, negative regulation of interleukin-6 production, negative regulation of lipopolysaccharide-mediated signaling pathway, negative regulation of macrophage inflammatory protein 1 alpha production, negative regulation of nitric oxide biosynthetic process, negative regulation of phagocytosis, negative regulation of tumor necrosis factor production, positive regulation of T cell activation, positive regulation of phagocytosis, positive regulation of reactive oxygen species metabolic process, regulation of gene expression, regulation of interleukin-1 beta production, regulation of interleukin-6 production, regulation of nitric oxide biosynthetic process, regulation of tumor necrosis factor production, regulation of type II interferon production; MF: GTPase regulator activity, SH3 domain binding, cell-cell adhesion mediator activity, protein antigen binding, protein binding, protein binding involved in heterotypic cell-cell adhesion, protein phosphatase binding, protein phosphatase inhibitor activity, protein tyrosine kinase binding; CC: cell surface, extracellular exosome, ficolin-1-rich granule membrane, membrane, plasma membrane, tertiary granule membrane
Pathways: Brain-derived neurotrophic factor (BDNF) signaling pathway, Cardiac Progenitor Differentiation, Cell surface interactions at the vascular wall, Cell-Cell communication, EGFR1, Hemostasis, Immune System, Innate Immune System, Male infertility, Neutrophil degranulation, Osteoclast differentiation - Homo sapiens (human), Prolactin, Prolactin Signaling Pathway, Signal regulatory protein family interactions
UniProt: P78324
Entrez ID: 140885
|
Does Knockout of PFDN6 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
PFDN6
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: PFDN6 (prefoldin subunit 6)
Type: protein-coding
Summary: PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010].
Gene Ontology: BP: chaperone-mediated protein complex assembly, negative regulation of amyloid fibril formation, protein folding, protein stabilization; MF: amyloid-beta binding, protein binding, protein-folding chaperone binding, unfolded protein binding; CC: RPAP3/R2TP/prefoldin-like complex, cytoplasm, prefoldin complex, protein folding chaperone complex, protein-containing complex
Pathways: Cellular Proteostasis, Chaperonin-mediated protein folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Metabolism of proteins, Prefoldin mediated transfer of substrate to CCT/TriC, Protein folding
UniProt: O15212
Entrez ID: 10471
|
Does Knockout of RTN2 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
RTN2
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: RTN2 (reticulon 2)
Type: protein-coding
Summary: This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Reticulon proteins also play an important role in the replication of positive-strand RNA (ssRNA) viruses. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: brain development, endoplasmic reticulum tubular network formation, endoplasmic reticulum tubular network membrane organization, gene expression, intracellular protein transmembrane transport, negative regulation of amyloid-beta formation, neuron differentiation, protein transport, regulation of D-glucose import; CC: T-tubule, Z disc, cell surface, cytoplasm, cytoskeleton, endoplasmic reticulum, endoplasmic reticulum membrane, intermediate filament, membrane, neuron projection, plasma membrane, postsynaptic density, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum membrane, terminal cisterna
Pathways:
UniProt: O75298
Entrez ID: 6253
|
Does Knockout of KCNS2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
KCNS2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: KCNS2 (potassium voltage-gated channel modifier subfamily S member 2)
Type: protein-coding
Summary: Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of delayed rectifier potassium channel activity. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, protein homooligomerization, regulation of potassium ion transmembrane transport, transmembrane transport; MF: monoatomic ion channel activity, potassium channel activity, potassium channel regulator activity, protein binding, voltage-gated potassium channel activity; CC: cytoplasm, membrane, monoatomic ion channel complex, perinuclear region of cytoplasm, plasma membrane, voltage-gated potassium channel complex
Pathways: Neuronal System, Potassium Channels, Voltage gated Potassium channels
UniProt: Q9ULS6
Entrez ID: 3788
|
Does Knockout of CNOT9 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
CNOT9
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: CNOT9 (CCR4-NOT transcription complex subunit 9)
Type: protein-coding
Summary: This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: cytokine-mediated signaling pathway, mRNA catabolic process, negative regulation of intracellular estrogen receptor signaling pathway, negative regulation of translation, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of DNA-templated transcription, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of peptidyl-serine phosphorylation, regulation of translation, regulatory ncRNA-mediated gene silencing, sex differentiation; MF: epidermal growth factor receptor binding, kinase binding, protein binding, protein domain specific binding, protein homodimerization activity, transcription coactivator activity; CC: CCR4-NOT complex, CCR4-NOT core complex, P-body, cytoplasm, cytosol, membrane, nucleus, protein-containing complex
Pathways: RNA degradation - Homo sapiens (human)
UniProt: Q92600
Entrez ID: 9125
|
Does Knockout of ITGAV in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
ITGAV
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: ITGAV (integrin subunit alpha V)
Type: protein-coding
Summary: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: ERK1 and ERK2 cascade, angiogenesis, apolipoprotein A-I-mediated signaling pathway, apoptotic cell clearance, blood vessel development, calcium ion transmembrane transport, cell adhesion, cell adhesion mediated by integrin, cell migration, cell-cell adhesion, cell-matrix adhesion, cell-substrate adhesion, endodermal cell differentiation, entry into host cell by a symbiont-containing vacuole, extrinsic apoptotic signaling pathway in absence of ligand, formation of primary germ layer, heterotypic cell-cell adhesion, integrin-mediated signaling pathway, negative chemotaxis, negative regulation of entry of bacterium into host cell, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of lipid storage, negative regulation of lipid transport, negative regulation of lipoprotein metabolic process, negative regulation of low-density lipoprotein particle clearance, negative regulation of macrophage derived foam cell differentiation, positive regulation of cell adhesion, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cytosolic calcium ion concentration, positive regulation of intracellular signal transduction, positive regulation of osteoblast proliferation, positive regulation of small GTPase mediated signal transduction, regulation of phagocytosis, substrate adhesion-dependent cell spreading, symbiont entry into host cell, tissue development, transforming growth factor beta production, vasculogenesis, wound healing, spreading of epidermal cells; MF: C-X3-C chemokine binding, coreceptor activity, extracellular matrix binding, extracellular matrix protein binding, fibroblast growth factor binding, fibronectin binding, insulin-like growth factor I binding, integrin binding, metal ion binding, neuregulin binding, opsonin binding, protease binding, protein binding, protein kinase C binding, signaling receptor activity, signaling receptor binding, transforming growth factor beta binding, virus receptor activity; CC: alphav-beta3 integrin-HMGB1 complex, alphav-beta3 integrin-IGF-1-IGF1R complex, alphav-beta3 integrin-PKCalpha complex, anchoring junction, cell surface, cytosol, external side of plasma membrane, extracellular exosome, filopodium membrane, focal adhesion, integrin alphav-beta1 complex, integrin alphav-beta3 complex, integrin alphav-beta5 complex, integrin alphav-beta6 complex, integrin alphav-beta8 complex, integrin complex, lamellipodium membrane, membrane, microvillus membrane, phagocytic vesicle, plasma membrane, ruffle membrane, specific granule membrane
Pathways: Adaptive Immune System, Antigen processing-Cross presentation, Arf6 trafficking events, Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Axon guidance, Beta1 integrin cell surface interactions, Beta3 integrin cell surface interactions, Beta5 beta6 beta7 and beta8 integrin cell surface interactions, Cell adhesion molecules - Homo sapiens (human), Cell surface interactions at the vascular wall, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Class I MHC mediated antigen processing & presentation, Cross-presentation of particulate exogenous antigens (phagosomes), Developmental Biology, Dilated cardiomyopathy - Homo sapiens (human), ECM proteoglycans, ECM-receptor interaction - Homo sapiens (human), Ebola Virus Pathway on Host, Elastic fibre formation, Extracellular matrix organization, Fibroblast growth factor-1, Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Hemostasis, Hippo-Merlin Signaling Dysregulation, Human cytomegalovirus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Immune System, Innate Immune System, Integrin cell surface interactions, Integrin-mediated Cell Adhesion, Integrins in angiogenesis, L1CAM interactions, Laminin interactions, MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement, MFAP5-mediated ovarian cancer cell motility and invasiveness, Mechanical load activates signaling by PIEZO1 and integrins in osteocytes, Molecules associated with elastic fibres, Nectin adhesion pathway, Nervous system development, Neutrophil degranulation, Non-integrin membrane-ECM interactions, Osteoblast Signaling, Osteopontin Signaling, Osteopontin-mediated events, PDGFR-alpha signaling pathway, PDGFR-beta signaling pathway, PECAM1 interactions, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Phagosome - Homo sapiens (human), Plexin-D1 Signaling, Primary focal segmental glomerulosclerosis (FSGS), Proteoglycans in cancer - Homo sapiens (human), Regulation of actin cytoskeleton - Homo sapiens (human), Response of endothelial cells to shear stress, Signal Transduction, Signal transduction by L1, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by VEGF, Signaling events mediated by VEGFR1 and VEGFR2, Signaling events mediated by focal adhesion kinase, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Syndecan interactions, TGF-beta receptor signaling activates SMADs, Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells, Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling, VEGFA-VEGFR2 Pathway, VEGFA-VEGFR2 Signaling Pathway, phospholipids as signalling intermediaries
UniProt: P06756
Entrez ID: 3685
|
Does Knockout of PSMD4 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
PSMD4
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process; MF: RNA binding, identical protein binding, molecular adaptor activity, polyubiquitin modification-dependent protein binding, protein binding; CC: cytosol, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), ID, Metabolism of proteins, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, Spinocerebellar ataxia - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, proteasome complex
UniProt: P55036
Entrez ID: 5710
|
Does Knockout of TARDBP in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
TARDBP
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: TARDBP (TAR DNA binding protein)
Type: protein-coding
Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, 3'-UTR-mediated mRNA stabilization, RNA splicing, amyloid fibril formation, gene expression, host-mediated suppression of viral transcription, mRNA processing, negative regulation of gene expression, negative regulation of protein phosphorylation, nuclear inner membrane organization, positive regulation of insulin secretion, positive regulation of protein import into nucleus, regulation of apoptotic process, regulation of cell cycle, regulation of circadian rhythm, regulation of gene expression, regulation of protein stability, response to endoplasmic reticulum stress, rhythmic process; MF: DNA binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, identical protein binding, lipid binding, mRNA 3'-UTR binding, molecular condensate scaffold activity, nucleic acid binding, pre-mRNA intronic binding, protein binding; CC: chromatin, cytoplasm, cytoplasmic stress granule, interchromatin granule, mitochondrion, nuclear speck, nucleoplasm, nucleus, perichromatin fibrils
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), MECP2 and Associated Rett Syndrome, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), RNA transport - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q13148
Entrez ID: 23435
|
Does Activation of COX7A2L in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
COX7A2L
|
protein/peptide accumulation
|
T cell
|
Gene: COX7A2L (cytochrome c oxidase subunit 7A2 like)
Type: protein-coding
Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: mitochondrial electron transport, cytochrome c to oxygen, mitochondrial respirasome assembly, proton transmembrane transport; MF: cytochrome-c oxidase activity, protein-macromolecule adaptor activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleolus, respiratory chain complex IV
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Complex IV assembly, Cytoprotection by HMOX1, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Gene expression (Transcription), Generic Transcription Pathway, Huntington disease - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), RNA Polymerase II Transcription, Respiratory electron transport, TP53 Regulates Metabolic Genes, Thermogenesis - Homo sapiens (human), Transcriptional Regulation by TP53
UniProt: O14548
Entrez ID: 9167
|
Does Knockout of AK1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
AK1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: AK1 (adenylate kinase 1)
Type: protein-coding
Summary: This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene shares readthrough transcripts with the upstream ST6GALNAC6 gene. [provided by RefSeq, Jan 2022].
Gene Ontology: BP: ADP biosynthetic process, AMP metabolic process, ATP metabolic process, nucleobase-containing compound metabolic process, nucleobase-containing small molecule interconversion, nucleoside monophosphate phosphorylation, nucleoside triphosphate biosynthetic process; MF: AMP kinase activity, ATP binding, dAMP kinase activity, kinase activity, nucleobase-containing compound kinase activity, nucleoside diphosphate kinase activity, nucleoside monophosphate kinase activity, nucleotide binding, transferase activity; CC: cytoplasm, cytosol, extracellular exosome, outer dense fiber, sperm flagellum
Pathways: AICA-Ribosiduria, Adefovir Dipivoxil Metabolism Pathway, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Gout or Kelley-Seegmiller Syndrome, Interconversion of nucleotide di- and triphosphates, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Tenofovir Metabolism Pathway, Thiamine metabolism - Homo sapiens (human), Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, adenosine ribonucleotides <i>de novo</i> biosynthesis, purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: P00568
Entrez ID: 203
|
Does Knockout of CCT5 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
CCT5
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: CCT5 (chaperonin containing TCP1 subunit 5)
Type: protein-coding
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of protein localization to Cajal body, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, response to virus; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, G-protein beta-subunit binding, beta-tubulin binding, hydrolase activity, mRNA 3'-UTR binding, mRNA 5'-UTR binding, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, centrosome, chaperonin-containing T-complex, cytoplasm, cytoskeleton, cytosol, extracellular exosome, microtubule
Pathways: 16p11.2 proximal deletion syndrome, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Chaperonin-mediated protein folding, Cilium Assembly, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Folding of actin by CCT/TriC, Formation of tubulin folding intermediates by CCT/TriC, Metabolism of proteins, Organelle biogenesis and maintenance, Prefoldin mediated transfer of substrate to CCT/TriC, Protein folding
UniProt: P48643
Entrez ID: 22948
|
Does Knockout of SRP19 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
SRP19
|
response to virus
|
Hepatoma Cell Line
|
Gene: SRP19 (signal recognition particle 19)
Type: protein-coding
Summary: Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, cotranslational protein targeting to membrane; MF: 7S RNA binding, RNA binding, protein binding, ribosome binding; CC: cytoplasm, cytosol, nuclear body, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Homo sapiens (human), SRP-dependent cotranslational protein targeting to membrane, Translation
UniProt: P09132
Entrez ID: 6728
|
Does Knockout of NPHP4 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
NPHP4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: NPHP4 (nephrocystin 4)
Type: protein-coding
Summary: This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: actin cytoskeleton organization, cell-cell adhesion, flagellated sperm motility, negative regulation of canonical Wnt signaling pathway, photoreceptor cell maintenance, photoreceptor cell outer segment organization, positive regulation of bicellular tight junction assembly, protein localization to ciliary transition zone, retina development in camera-type eye, signal transduction, visual behavior; MF: protein binding, structural molecule activity; CC: anchoring junction, bicellular tight junction, cell projection, cell-cell junction, centriole, centrosome, ciliary basal body, ciliary base, ciliary transition zone, cilium, cytoplasm, cytoskeleton, cytosol, non-motile cilium, nuclear body, nucleoplasm, nucleus, photoreceptor connecting cilium, photoreceptor distal connecting cilium, ribbon synapse
Pathways: Anchoring of the basal body to the plasma membrane, Ciliopathies, Cilium Assembly, Joubert Syndrome, Organelle biogenesis and maintenance, Signal Transduction, Signaling by Hippo
UniProt: O75161
Entrez ID: 261734
|
Does Knockout of IFT74 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
IFT74
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: IFT74 (intraflagellar transport 74)
Type: protein-coding
Summary: This gene encodes a core intraflagellar transport (IFT) protein which belongs to a multi-protein complex involved in the transport of ciliary proteins along axonemal microtubules. IFT proteins are found at the base of the cilium as well as inside the cilium, where they assemble into long arrays between the ciliary base and tip. This protein, together with intraflagellar transport protein 81, binds and transports tubulin within cilia and is required for ciliogenesis. Naturally occurring mutations in this gene are associated with amyotrophic lateral sclerosis--frontotemporal dementia and Bardet-Biedl Syndrome. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: Notch signaling pathway, cell projection organization, cilium assembly, determination of left/right symmetry, epidermis development, heart development, intraciliary anterograde transport, intraciliary transport, intraciliary transport involved in cilium assembly, keratinocyte development, keratinocyte proliferation, negative regulation of epithelial cell proliferation, negative regulation of keratinocyte proliferation, non-motile cilium assembly, positive regulation of cell adhesion mediated by integrin, positive regulation of transcription by RNA polymerase II; MF: beta-tubulin binding, chromatin binding, protein binding; CC: acrosomal vesicle, cell projection, centrosome, ciliary tip, cilium, cytoplasmic vesicle, intraciliary transport particle B, motile cilium, nucleus
Pathways: Ciliary landscape, Genes related to primary cilium development (based on CRISPR)
UniProt: Q96LB3
Entrez ID: 80173
|
Does Knockout of FARP1 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
FARP1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: FARP1 (FERM, ARH/RhoGEF and pleckstrin domain protein 1)
Type: protein-coding
Summary: This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].
Gene Ontology: BP: Rac protein signal transduction, dendrite morphogenesis, enzyme-linked receptor protein signaling pathway, positive regulation of skeletal muscle acetylcholine-gated channel clustering, postsynaptic actin cytoskeleton organization, regulation of presynapse assembly, retrograde trans-synaptic signaling by trans-synaptic protein complex, synapse assembly; MF: cytoskeletal protein binding, guanyl-nucleotide exchange factor activity, protein binding, small GTPase binding; CC: cell projection, cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, dendrite, dendritic spine, extrinsic component of postsynaptic membrane, filopodium, glutamatergic synapse, membrane, neuron projection, plasma membrane, synapse
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOF GTPase cycle, Regulation of RhoA activity, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9Y4F1
Entrez ID: 10160
|
Does Knockout of ELF2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
ELF2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ELF2 (E74 like ETS transcription factor 2)
Type: protein-coding
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, negative regulation of DNA-templated transcription, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Angiopoietin receptor Tie2-mediated signaling, Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in BCR signaling, Transcriptional regulation by RUNX1
UniProt: Q15723
Entrez ID: 1998
|
Does Knockout of NXF5 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
NXF5
|
response to virus
|
Huh-7 Cell
|
Gene: NXF5 (nuclear RNA export factor 5)
Type: pseudo
Summary: This gene is one member of a family of nuclear RNA export factor genes. Most transcript variants are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo. [provided by RefSeq, Sep 2022].
Gene Ontology: BP: RNA transport, mRNA export from nucleus, mRNA transport, poly(A)+ mRNA export from nucleus; MF: RNA binding, nucleic acid binding, protein binding; CC: cytoplasm, nuclear RNA export factor complex, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Influenza A - Homo sapiens (human), RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt:
Entrez ID: 55998
|
Does Knockout of AANAT in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
AANAT
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: AANAT (aralkylamine N-acetyltransferase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: N-terminal protein amino acid acetylation, cellular response to cAMP, circadian rhythm, indolalkylamine biosynthetic process, melatonin biosynthetic process, photoperiodism, response to cAMP, response to calcium ion, response to copper ion, response to corticosterone, response to cytokine, response to insulin, response to light stimulus, response to peptide, response to prostaglandin E, response to zinc ion, rhythmic process; MF: 14-3-3 protein binding, N-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, aralkylamine N-acetyltransferase activity, arylamine N-acetyltransferase activity, protein binding, transferase activity; CC: cytoplasm, cytosol, perinuclear region of cytoplasm
Pathways: Biogenic Amine Synthesis, Melatonin metabolism and effects, Metabolism, Metabolism of amine-derived hormones, Metabolism of amino acids and derivatives, Serotonin and melatonin biosynthesis, Tryptophan Metabolism, Tryptophan metabolism, Tryptophan metabolism - Homo sapiens (human), serotonin and melatonin biosynthesis, superpathway of tryptophan utilization
UniProt: Q16613
Entrez ID: 15
|
Does Knockout of UBL5 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
UBL5
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: UBL5 (ubiquitin like 5)
Type: protein-coding
Summary: This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: mRNA splicing, via spliceosome, positive regulation of protein targeting to mitochondrion, protein modification process; MF: protein binding, protein tag activity; CC: Cajal body, cytoplasm, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9BZL1
Entrez ID: 59286
|
Does Knockout of MUC6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
MUC6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: MUC6 (mucin 6, oligomeric mucus/gel-forming (gene/pseudogene))
Type: protein-coding
Summary: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016].
Gene Ontology: MF: extracellular matrix structural constituent; CC: Golgi lumen, extracellular matrix, extracellular region, extracellular space, plasma membrane
Pathways: C-type lectin receptors (CLRs), Dectin-2 family, Defective C1GALT1C1 causes TNPS, Defective GALNT12 causes CRCS1, Defective GALNT3 causes HFTC, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Gastric acid production, Immune System, Innate Immune System, Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, Termination of O-glycan biosynthesis
UniProt: Q6W4X9
Entrez ID: 4588
|
Does Activation of FGF5 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
FGF5
|
protein/peptide accumulation
|
T cell
|
Gene: FGF5 (fibroblast growth factor 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell-cell signaling, fibroblast growth factor receptor signaling pathway, glial cell differentiation, nervous system development, neurogenesis, positive regulation of MAPK cascade, positive regulation of cell division, positive regulation of cell population proliferation, regulation of cell migration, signal transduction, signal transduction involved in regulation of gene expression; MF: fibroblast growth factor receptor binding, growth factor activity; CC: cytoplasm, extracellular region, extracellular space
Pathways: Activated point mutants of FGFR2, Breast cancer - Homo sapiens (human), Breast cancer pathway, Calcium signaling pathway - Homo sapiens (human), Constitutive Signaling by Aberrant PI3K in Cancer, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, ESC Pluripotency Pathways, FGFR1 ligand binding and activation, FGFR1 mutant receptor activation, FGFR1c ligand binding and activation, FGFR2 ligand binding and activation, FGFR2 mutant receptor activation, FGFR2c ligand binding and activation, FGFR3 ligand binding and activation, FGFR3 mutant receptor activation, FGFR3c ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, Gastric cancer - Homo sapiens (human), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, MECP2 and Associated Rett Syndrome, Melanoma - Homo sapiens (human), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of the PI3K/AKT network, Osteoblast differentiation, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI3K Cascade, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Homo sapiens (human), Phospholipase C-mediated cascade: FGFR1, Phospholipase C-mediated cascade; FGFR2, Phospholipase C-mediated cascade; FGFR3, RAF/MAP kinase cascade, Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR1, Signaling by FGFR1 in disease, Signaling by FGFR2, Signaling by FGFR2 in disease, Signaling by FGFR3, Signaling by FGFR3 in disease, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by activated point mutants of FGFR1, Signaling by activated point mutants of FGFR3
UniProt: P12034
Entrez ID: 2250
|
Does Knockout of PAICS in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
PAICS
|
cell proliferation
|
Melanoma Cell Line
|
Gene: PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase)
Type: protein-coding
Summary: This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, purine nucleobase biosynthetic process, purine nucleotide biosynthetic process; MF: ATP binding, cadherin binding, carboxy-lyase activity, catalytic activity, identical protein binding, ligase activity, lyase activity, nucleotide binding, phosphoribosylaminoimidazole carboxylase activity, phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, protein binding; CC: cytoplasm, cytosol, extracellular exosome, membrane
Pathways: AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Gout or Kelley-Seegmiller Syndrome, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide biosynthesis, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Purine ribonucleoside monophosphate biosynthesis, Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, inosine-5,-phosphate biosynthesis, purine nucleotides <i>de novo</i> biosynthesis
UniProt: P22234
Entrez ID: 10606
|
Does Knockout of CAPN3 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
CAPN3
|
cell proliferation
|
T-lymphoma cell line
|
Gene: CAPN3 (calpain 3)
Type: protein-coding
Summary: Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G1 to G0 transition involved in cell differentiation, apoptotic process, calcium-dependent self proteolysis, cellular response to calcium ion, cellular response to salt stress, muscle cell cellular homeostasis, muscle organ development, muscle structure development, myofibril assembly, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of protein sumoylation, positive regulation of DNA-templated transcription, positive regulation of proteolysis, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of satellite cell activation involved in skeletal muscle regeneration, programmed cell death, protein catabolic process, protein destabilization, protein localization to membrane, protein-containing complex assembly, proteolysis, regulation of canonical NF-kappaB signal transduction, regulation of myoblast differentiation, response to calcium ion, response to muscle activity, sarcomere organization, self proteolysis; MF: calcium ion binding, calcium-dependent cysteine-type endopeptidase activity, catalytic activity, cysteine-type peptidase activity, hydrolase activity, identical protein binding, ligase regulator activity, metal ion binding, molecular adaptor activity, peptidase activity, protein binding, sodium ion binding, structural constituent of muscle, titin binding; CC: T-tubule, Z disc, cytoplasm, cytosol, myofibril, nucleolus, nucleus, plasma membrane, protein-containing complex
Pathways: Integrin-mediated Cell Adhesion
UniProt: P20807
Entrez ID: 825
|
Does Knockout of GNL2 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
GNL2
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: GNL2 (G protein nucleolar 2)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in ribosome biogenesis. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTP binding, GTPase activity, RNA binding, nucleotide binding; CC: membrane, nucleolus, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q13823
Entrez ID: 29889
|
Does Knockout of SPC24 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
SPC24
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: SPC24 (SPC24 component of NDC80 kinetochore complex)
Type: protein-coding
Summary: Predicted to be involved in cell division. Located in nucleolus and nucleoplasm. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, mitotic spindle assembly checkpoint signaling; MF: microtubule binding, protein binding; CC: Ndc80 complex, chromosome, chromosome, centromeric region, cytosol, kinetochore, nucleolus, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, PLK1 signaling events, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8NBT2
Entrez ID: 147841
|
Does Knockout of CEP120 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
CEP120
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CEP120 (centrosomal protein 120)
Type: protein-coding
Summary: This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: astral microtubule organization, cell population proliferation, centrosome cycle, cerebral cortex development, interkinetic nuclear migration, microtubule cytoskeleton organization, neurogenesis, positive regulation of cell cycle process, positive regulation of centriole elongation, positive regulation of centrosome duplication, positive regulation of cilium assembly, positive regulation of establishment of protein localization, positive regulation of organelle assembly, regulation of centrosome duplication, regulation of microtubule-based process, regulation of protein localization; CC: centriole, centrosome, cytoplasm, cytoskeleton
Pathways: Ciliopathies, Genes related to primary cilium development (based on CRISPR), Joubert Syndrome
UniProt: Q8N960
Entrez ID: 153241
|
Does Knockout of DSCR4 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
DSCR4
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: DSCR4 (Down syndrome critical region 4)
Type: ncRNA
Summary: The gene is found in a region of chromosome 21 that has been linked to the pathogenesis of Down syndrome. This gene is transcribed from a bi-directional promoter located in an endogenous retrovirus. [provided by RefSeq, Jan 2015].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 10281
|
Does Knockout of PCID2 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
PCID2
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: PCID2 (PCI domain containing 2)
Type: protein-coding
Summary: This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: mRNA transport, negative regulation of gene expression, epigenetic, negative regulation of lymphoid progenitor cell differentiation, poly(A)+ mRNA export from nucleus, positive regulation of B cell differentiation, post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery, protein transport, spleen development, transcription elongation by RNA polymerase II; MF: RNA binding, double-stranded DNA binding, protein binding; CC: cytoplasm, nuclear pore, nuclear pore nuclear basket, nucleus, protein-containing complex, transcription export complex 2
Pathways:
UniProt: Q5JVF3
Entrez ID: 55795
|
Does Knockout of PRPF40A in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
PRPF40A
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PRPF40A (pre-mRNA processing factor 40A)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in several processes, including cytoskeleton organization; regulation of cell shape; and regulation of cytokinesis. Located in nuclear matrix and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, cell division, cell migration, cytoskeleton organization, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, regulation of cell shape, regulation of cytokinesis; MF: RNA binding, protein binding; CC: U1 snRNP, U2-type prespliceosome, membrane, nuclear matrix, nuclear speck, nucleoplasm, nucleus
Pathways: Spliceosome - Homo sapiens (human), mRNA Processing
UniProt: O75400
Entrez ID: 55660
|
Does Knockout of TECR in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
TECR
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TECR (trans-2,3-enoyl-CoA reductase)
Type: protein-coding
Summary: This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011].
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid elongation, fatty acid metabolic process, lipid metabolic process, long-chain fatty-acyl-CoA biosynthetic process, sphingolipid metabolic process, very long-chain fatty acid biosynthetic process; MF: oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, protein binding, very-long-chain enoyl-CoA reductase activity, very-long-chain fatty acyl-CoA dehydrogenase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Biosynthesis of unsaturated fatty acids - Homo sapiens (human), Fatty acid elongation - Homo sapiens (human), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Fragile X Syndrome, Metabolism, Metabolism of lipids, Synthesis of very long-chain fatty acyl-CoAs
UniProt: Q9NZ01
Entrez ID: 9524
|
Does Knockout of ELAVL1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
ELAVL1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: ELAVL1 (ELAV like RNA binding protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012].
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, cell population proliferation, lncRNA-mediated post-transcriptional gene silencing, mRNA destabilization, mRNA stabilization, negative regulation of miRNA-mediated gene silencing, positive regulation of autophagosome size, positive regulation of autophagy, positive regulation of superoxide anion generation, positive regulation of translation, post-transcriptional gene silencing, protein homooligomerization, protein import into nucleus, regulation of mRNA stability, regulation of stem cell population maintenance, response to glucose; MF: RNA binding, double-stranded RNA binding, lncRNA binding, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, mRNA binding, miRNA binding, nucleic acid binding, protein binding, protein homodimerization activity, protein kinase binding; CC: P-body, cytoplasm, cytoplasmic stress granule, cytoplasmic vesicle, cytosol, endoplasmic reticulum, glutamatergic synapse, membrane, nucleoplasm, nucleus, postsynapse, ribonucleoprotein complex, sarcoplasm
Pathways: AMP-activated protein kinase (AMPK) signaling, AMPK signaling pathway - Homo sapiens (human), Endoderm differentiation, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Gastrin, Gastrin signaling pathway, HuR (ELAVL1) binds and stabilizes mRNA, IL-17 signaling pathway - Homo sapiens (human), IL-18 signaling pathway, Metabolism of RNA, NAD Metabolism in Oncogene-Induced Senescence and Mitochondrial Dysfunction-Associated Senescence, Pre-implantation embryo, Regulation of mRNA stability by proteins that bind AU-rich elements, ncRNAs involved in Wnt signaling in hepatocellular carcinoma
UniProt: Q15717
Entrez ID: 1994
|
Does Knockout of CCNK in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
CCNK
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CCNK (cyclin K)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, cell division, host-mediated suppression of viral genome replication, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of cell cycle, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of signal transduction, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein binding, protein kinase binding; CC: cyclin K-CDK12 complex, cyclin K-CDK13 complex, cyclin-dependent protein kinase holoenzyme complex, cyclin/CDK positive transcription elongation factor complex, nucleoplasm, nucleus
Pathways: Direct p53 effectors, Male infertility
UniProt: O75909
Entrez ID: 8812
|
Does Knockout of LYRM9 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
LYRM9
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: LYRM9 (LYR motif containing 9)
Type: protein-coding
Summary: Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: A8MSI8
Entrez ID: 201229
|
Does Knockout of USP25 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
USP25
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: USP25 (ubiquitin specific peptidase 25)
Type: protein-coding
Summary: Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cellular response to oxidative stress, interleukin-17A-mediated signaling pathway, negative regulation of ERAD pathway, negative regulation of interleukin-17-mediated signaling pathway, negative regulation of response to oxidative stress, protein K48-linked deubiquitination, protein K48-linked ubiquitination, protein K63-linked deubiquitination, protein deubiquitination, protein modification process, proteolysis, regulation of protein stability; MF: ATPase binding, SUMO binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, deubiquitinase activity, hydrolase activity, peptidase activity, protein binding, ubiquitin binding, ubiquitin protein ligase binding, ubiquitin-like protein peptidase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, nucleus
Pathways: Deubiquitination, IL-17 signaling pathway - Homo sapiens (human), Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q9UHP3
Entrez ID: 29761
|
Does Knockout of NRBP1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
NRBP1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: NRBP1 (nuclear receptor binding protein 1)
Type: protein-coding
Summary: Predicted to enable protein homodimerization activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, endoplasmic reticulum to Golgi vesicle-mediated transport; MF: ATP binding, protein binding, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity; CC: cell cortex, cell projection, cytoplasm, endomembrane system, lamellipodium, membrane, nucleoplasm
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription
UniProt: Q9UHY1
Entrez ID: 29959
|
Does Knockout of FLG2 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
FLG2
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: FLG2 (filaggrin 2)
Type: protein-coding
Summary: The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa and E. coli. [provided by RefSeq, Jul 2020].
Gene Ontology: BP: cell adhesion, epidermis morphogenesis, establishment of skin barrier; MF: calcium ion binding, metal ion binding, structural molecule activity, transition metal ion binding; CC: cornified envelope, cytoplasm, extracellular region, keratohyalin granule, nucleus, tertiary granule lumen
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q5D862
Entrez ID: 388698
|
Does Knockout of MPZL1 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
MPZL1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: MPZL1 (myelin protein zero like 1)
Type: protein-coding
Summary: Predicted to enable structural molecule activity. Predicted to be involved in cell-cell signaling and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within positive regulation of cell migration. Located in cell surface and focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, cell-cell signaling; MF: protein binding, structural molecule activity; CC: cell surface, focal adhesion, membrane, plasma membrane
Pathways: Cell adhesion molecules - Homo sapiens (human), EGFR1, TCR
UniProt: O95297
Entrez ID: 9019
|
Does Knockout of NCAM1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
NCAM1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: NCAM1 (neural cell adhesion molecule 1)
Type: protein-coding
Summary: This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: cell adhesion, commissural neuron axon guidance, epithelial to mesenchymal transition, regulation of semaphorin-plexin signaling pathway, symbiont entry into host cell; MF: protein binding, virus receptor activity; CC: Golgi membrane, cell surface, cytosol, external side of plasma membrane, extracellular matrix, extracellular region, membrane, neuron projection, plasma membrane, side of membrane
Pathways: Axon guidance, Brain-derived neurotrophic factor (BDNF) signaling pathway, Cardiac Progenitor Differentiation, Cell adhesion molecules - Homo sapiens (human), Cytokine Signaling in Immune system, Developmental Biology, ECM proteoglycans, Extracellular matrix organization, FGF signaling pathway, Immune System, Interferon Signaling, Interferon gamma signaling, L1CAM interactions, MAPK family signaling cascades, MAPK1/MAPK3 signaling, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Prion disease - Homo sapiens (human), Prion disease pathway, RAF/MAP kinase cascade, Signal Transduction, Signal transduction by L1
UniProt: P13591
Entrez ID: 4684
|
Does Knockout of MDN1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
MDN1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MDN1 (midasin AAA ATPase 1)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. Involved in ribosomal large subunit assembly. Located in cytosol; intermediate filament cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ribosomal large subunit assembly, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, nucleotide binding, protein binding; CC: cytoplasm, cytosol, intermediate filament cytoskeleton, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q9NU22
Entrez ID: 23195
|
Does Knockout of TUBA1B in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
TUBA1B
|
cell proliferation
|
Melanoma Cell Line
|
Gene: TUBA1B (tubulin alpha 1b)
Type: protein-coding
Summary: Enables double-stranded RNA binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within cellular response to interleukin-4. Located in microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, cellular response to interleukin-4, cytoskeleton-dependent intracellular transport, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, GTPase activity, double-stranded RNA binding, hydrolase activity, nucleotide binding, protein binding, structural constituent of cytoskeleton, structural molecule activity, ubiquitin protein ligase binding; CC: cilium, cytoplasm, cytoplasmic microtubule, cytoskeleton, microtubule, microtubule cytoskeleton
Pathways: Activation of AMPK downstream of NMDARs, Activation of NMDA receptors and postsynaptic events, Adaptive Immune System, Aggrephagy, Allograft Rejection, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Apoptosis - Homo sapiens (human), Asparagine N-linked glycosylation, Assembly and cell surface presentation of NMDA receptors, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Chaperonin-mediated protein folding, Cilium Assembly, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Cytokine Signaling in Immune system, Developmental Biology, Disease, Docetaxel Action Pathway, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, Formation of tubulin folding intermediates by CCT/TriC, G2/M Transition, Gap junction - Homo sapiens (human), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HCMV Early Events, HCMV Infection, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hedgehog 'off' state, Hemostasis, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, L1CAM interactions, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Paclitaxel Action Pathway, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phagosome - Homo sapiens (human), Post NMDA receptor activation events, Post-chaperonin tubulin folding pathway, Post-translational protein modification, Prion disease - Homo sapiens (human), Protein folding, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, RHOH GTPase cycle, Recruitment of NuMA to mitotic centrosomes, Recycling pathway of L1, Resolution of Sister Chromatid Cohesion, Salmonella infection - Homo sapiens (human), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling events mediated by HDAC Class II, Signaling events mediated by HDAC Class III, Signaling events mediated by PRL, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, Transmission across Chemical Synapses, Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, Vinblastine Action Pathway, Vincristine Action Pathway, Vindesine Action Pathway, Vinorelbine Action Pathway, Viral Infection Pathways
UniProt: P68363
Entrez ID: 10376
|
Does Knockout of DCTN2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
DCTN2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: DCTN2 (dynactin subunit 2)
Type: protein-coding
Summary: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: melanosome transport, microtubule-based process, mitotic metaphase chromosome alignment, mitotic spindle organization, protein localization to centrosome; MF: identical protein binding, protein binding, protein kinase binding, spectrin binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, dynactin complex, dynein complex, extracellular exosome, growth cone, kinetochore, membrane, microtubule, vesicle
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Salmonella infection - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, lissencephaly gene (lis1) in neuronal migration and development
UniProt: Q13561
Entrez ID: 10540
|
Does Knockout of HDAC3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
HDAC3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: HDAC3 (histone deacetylase 3)
Type: protein-coding
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA repair-dependent chromatin remodeling, cellular response to fluid shear stress, cellular response to mechanical stimulus, cellular response to parathyroid hormone stimulus, chromatin organization, circadian regulation of gene expression, cornified envelope assembly, epidermis development, epigenetic regulation of gene expression, establishment of mitotic spindle orientation, establishment of skin barrier, gene expression, in utero embryonic development, negative regulation of DNA-templated transcription, negative regulation of JNK cascade, negative regulation of apoptotic process, negative regulation of cardiac muscle cell differentiation, negative regulation of ferroptosis, negative regulation of interleukin-1 production, negative regulation of myotube differentiation, negative regulation of protein export from nucleus, negative regulation of transcription by RNA polymerase II, negative regulation of tumor necrosis factor production, neural precursor cell proliferation, positive regulation of TOR signaling, positive regulation of cold-induced thermogenesis, positive regulation of ferroptosis, positive regulation of neuron apoptotic process, positive regulation of protein import into nucleus, positive regulation of protein phosphorylation, positive regulation of protein ubiquitination, positive regulation of transcription by RNA polymerase II, positive regulation of type B pancreatic cell apoptotic process, protein deacetylation, protein modification process, random inactivation of X chromosome, regulation of circadian rhythm, regulation of mitotic cell cycle, regulation of multicellular organism growth, regulation of protein stability, response to dexamethasone, response to nutrient levels, response to xenobiotic stimulus, rhythmic process, spindle assembly, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor binding, GTPase binding, NF-kappaB binding, chromatin DNA binding, chromatin binding, cyclin binding, deacetylase activity, enzyme binding, histone deacetylase activity, histone deacetylase activity, hydrolytic mechanism, histone deacetylase binding, histone decrotonylase activity, hydrolase activity, protein binding, protein de-2-hydroxyisobutyrylase activity, protein decrotonylase activity, protein lysine deacetylase activity, protein lysine delactylase activity, transcription corepressor activity, transcription corepressor binding, ubiquitin-specific protease binding; CC: Golgi apparatus, chromatin, chromosome, cytoplasm, cytosol, histone deacetylase complex, mitotic spindle, nucleoplasm, nucleus, plasma membrane, transcription repressor complex
Pathways: 16p11.2 proximal deletion syndrome, 22q11.2 copy number variation syndrome, Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Adipogenesis, Alcoholism - Homo sapiens (human), Association of TriC/CCT with target proteins during biosynthesis, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chaperonin-mediated protein folding, Chromatin modifying enzymes, Chromatin organization, Circadian clock, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Cytoprotection by HMOX1, Death Receptor Signaling, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of Developmental Biology, Disorders of Nervous System Development, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Ethanol effects on histone modifications, Expression of BMAL (ARNTL), CLOCK, and NPAS2, Gene expression (Transcription), Generic Transcription Pathway, HCMV Early Events, HCMV Infection, HDACs deacetylate histones, Heme signaling, IL-18 signaling pathway, Infectious disease, Initiation of transcription and translation elongation at the HIV-1 LTR, Intracellular signaling by second messengers, Loss of MECP2 binding ability to the NCoR/SMRT complex, Loss of function of MECP2 in Rett syndrome, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, Metabolism of proteins, Mitochondrial biogenesis, NOTCH1 Intracellular Domain Regulates Transcription, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Neural Crest Differentiation, Neutrophil extracellular trap formation - Homo sapiens (human), Notch-HLH transcription pathway, Organelle biogenesis and maintenance, PIP3 activates AKT signaling, PPARA activates gene expression, PTEN Regulation, Pervasive developmental disorders, Protein folding, RNA Polymerase II Transcription, RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression, RUNX2 regulates bone development, RUNX2 regulates osteoblast differentiation, Regulation of MECP2 expression and activity, Regulation of PTEN gene transcription, Regulation of lipid metabolism by PPARalpha, Regulation of retinoblastoma protein, Retinoic acid receptors-mediated signaling, STAT3 nuclear events downstream of ALK signaling, Signal Transduction, Signaling by ALK, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Thyroid hormone signaling pathway - Homo sapiens (human), Transcription co-factors SKI and SKIL protein partners, Transcriptional Regulation by MECP2, Transcriptional activation of mitochondrial biogenesis, Transcriptional regulation by RUNX2, Transcriptional regulation of white adipocyte differentiation, Validated targets of C-MYC transcriptional repression, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), acetylation and deacetylation of rela in nucleus, nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells, p75 NTR receptor-mediated signalling, p75NTR negatively regulates cell cycle via SC1
UniProt: O15379
Entrez ID: 8841
|
Does Activation of DGCR6L in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
DGCR6L
|
protein/peptide accumulation
|
T cell
|
Gene: DGCR6L (DiGeorge syndrome critical region gene 6 like)
Type: protein-coding
Summary: This gene, the result of a duplication at this locus, is one of two functional genes encoding nearly identical proteins that have similar expression patterns. The product of this gene is a protein that shares homology with the Drosophila gonadal protein, expressed in gonadal tissues and germ cells, and with the human laminin gamma-1 chain that functions in cell attachment and migration. This gene is located in a region of chromosome 22 implicated in the DiGeorge syndrome, one facet of a broader collection of anomalies referred to as the CATCH 22 syndrome. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways: 22q11.2 copy number variation syndrome
UniProt: Q9BY27
Entrez ID: 85359
|
Does Knockout of MST1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
MST1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: MST1 (macrophage stimulating 1)
Type: protein-coding
Summary: The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010].
Gene Ontology: BP: negative regulation of gluconeogenesis, proteolysis, regulation of cAMP-dependent protein kinase activity, regulation of macromolecule metabolic process, regulation of receptor signaling pathway via JAK-STAT; MF: endopeptidase activity, protein binding, receptor tyrosine kinase binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Calcium signaling pathway - Homo sapiens (human), FoxO family signaling, Hippo-Merlin Signaling Dysregulation, Hippo-Yap signaling pathway, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Overview of leukocyte-intrinsic Hippo pathway functions, Pathways Regulating Hippo Signaling, Signal Transduction, Signaling by MST1, Signaling by Receptor Tyrosine Kinases, a6b1 and a6b4 Integrin signaling, amb2 Integrin signaling
UniProt: P26927
Entrez ID: 4485
|
Does Knockout of OR1A1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
OR1A1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: OR1A1 (olfactory receptor family 1 subfamily A member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, GPCRs, Class A Rhodopsin-like, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q9P1Q5
Entrez ID: 8383
|
Does Knockout of INPP5K in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
INPP5K
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: INPP5K (inositol polyphosphate-5-phosphatase K)
Type: protein-coding
Summary: This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, actin cytoskeleton organization, cellular response to cAMP, cellular response to epidermal growth factor stimulus, cellular response to hormone stimulus, cellular response to insulin stimulus, cellular response to oxygen-containing compound, cellular response to tumor necrosis factor, glucose homeostasis, glycerolipid metabolic process, host-mediated suppression of viral transcription, in utero embryonic development, lipid metabolic process, negative regulation of D-glucose transmembrane transport, negative regulation of DNA-templated transcription, negative regulation of RNA biosynthetic process, negative regulation of calcium ion transport, negative regulation of dephosphorylation, negative regulation of glycogen biosynthetic process, negative regulation of insulin receptor signaling pathway, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of protein targeting to membrane, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, negative regulation of stress fiber assembly, phosphatidylinositol biosynthetic process, phosphatidylinositol dephosphorylation, phospholipid metabolic process, positive regulation of DNA-templated transcription, positive regulation of renal water transport, positive regulation of urine volume, protein localization to plasma membrane, regulation of glycogen biosynthetic process, regulation of transport, response to insulin, ruffle assembly; MF: hydrolase activity, inositol bisphosphate phosphatase activity, inositol trisphosphate phosphatase activity, inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity, inositol-1,4,5-trisphosphate 5-phosphatase activity, inositol-polyphosphate 5-phosphatase activity, lipid phosphatase activity, phosphatase activity, phosphatidylinositol phosphate 5-phosphatase activity, phosphatidylinositol trisphosphate phosphatase activity, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity, protein binding, vasopressin receptor activity; CC: cytoplasm, cytosol, endoplasmic reticulum, membrane, neuron projection, nucleus, perinuclear region of cytoplasm, plasma membrane, ruffle, ruffle membrane, trans-Golgi network
Pathways: 1D-<i>myo</i>-inositol hexakisphosphate biosynthesis II (mammalian), 3-phosphoinositide degradation, D-<i>myo</i>-inositol (1,3,4)-trisphosphate biosynthesis, D-<i>myo</i>-inositol (1,4,5)-trisphosphate degradation, Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome, Inositol phosphate metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, Notch Signaling, PI Metabolism, Phospholipid metabolism, Synthesis of PIPs at the plasma membrane, VEGFA-VEGFR2 Signaling Pathway, superpathway of D-<i>myo</i>-inositol (1,4,5)-trisphosphate metabolism, superpathway of inositol phosphate compounds
UniProt: Q9BT40
Entrez ID: 51763
|
Does Knockout of RCOR1 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
RCOR1
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: RCOR1 (REST corepressor 1)
Type: protein-coding
Summary: This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011].
Gene Ontology: BP: chromatin organization, erythrocyte differentiation, negative regulation of DNA-templated transcription, negative regulation of gene expression, positive regulation of megakaryocyte differentiation, regulation of transcription by RNA polymerase II; MF: chromatin binding, enzyme binding, protein binding, transcription corepressor activity; CC: DNA repair complex, histone deacetylase complex, histone methyltransferase complex, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Disease, Factors involved in megakaryocyte development and platelet production, HDACs deacetylate histones, Hemostasis, Huntington disease - Homo sapiens (human), Infectious disease, Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, Potential therapeutics for SARS, Regulation of PTEN gene transcription, SARS-CoV Infections, Signal Transduction, Viral Infection Pathways
UniProt: Q9UKL0
Entrez ID: 23186
|
Does Knockout of PABPC1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
PABPC1
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PABPC1 (poly(A) binding protein cytoplasmic 1)
Type: protein-coding
Summary: This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010].
Gene Ontology: BP: CRD-mediated mRNA stabilization, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, mRNA stabilization, negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, positive regulation of cytoplasmic translation, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of viral genome replication, regulatory ncRNA-mediated gene silencing; MF: RNA binding, mRNA 3'-UTR binding, mRNA binding, nucleic acid binding, poly(A) binding, poly(U) RNA binding, protein binding, translation activator activity; CC: catalytic step 2 spliceosome, cell leading edge, cell projection, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, extracellular exosome, focal adhesion, lamellipodium, mCRD-mediated mRNA stability complex, membrane, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Acute viral myocarditis, Axon guidance, Cap-dependent Translation Initiation, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Developmental Biology, Endoderm differentiation, Eukaryotic Translation Initiation, L13a-mediated translational silencing of Ceruloplasmin expression, M-decay: degradation of maternal mRNAs by maternally stored factors, Maternal to zygotic transition (MZT), Metabolism of RNA, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), RNA degradation - Homo sapiens (human), RNA transport - Homo sapiens (human), Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Signaling by ROBO receptors, Translation, Translation Factors, Translation initiation complex formation, VEGFA-VEGFR2 Signaling Pathway, Z-decay: degradation of maternal mRNAs by zygotically expressed factors, mRNA surveillance pathway - Homo sapiens (human), regulation of eif-4e and p70s6 kinase, skeletal muscle hypertrophy is regulated via akt-mtor pathway
UniProt: P11940
Entrez ID: 26986
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