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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of IL1RAPL2 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
IL1RAPL2
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: IL1RAPL2 (interleukin 1 receptor accessory protein like 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic cognitive disability. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell surface receptor signaling pathway, central nervous system development, cytokine-mediated signaling pathway, nervous system development, regulation of presynapse assembly, signal transduction; MF: NAD+ nucleosidase activity, cyclic ADP-ribose generating, cytokine receptor activity, hydrolase activity, interleukin-1 receptor activity, interleukin-1, type II, blocking receptor activity; CC: cell surface, glutamatergic synapse, membrane, plasma membrane
Pathways: Neuronal System, Protein-protein interactions at synapses, Receptor-type tyrosine-protein phosphatases
UniProt: Q9NP60
Entrez ID: 26280
|
Does Knockout of TAF1D in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
TAF1D
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: TAF1D (TATA-box binding protein associated factor, RNA polymerase I subunit D)
Type: protein-coding
Summary: TAF1D is a member of the SL1 complex, which includes TBP (MIM 600075) and TAF1A (MIM 604903), TAF1B (MIM 604904), and TAF1C (MIM 604905), and plays a role in RNA polymerase I transcription (Wang et al., 2004 [PubMed 15520167]; Gorski et al., 2007 [PubMed 17318177]).[supplied by OMIM, Jun 2009].
Gene Ontology: MF: DNA binding, identical protein binding, protein binding; CC: RNA polymerase transcription factor SL1 complex, centriolar satellite, cytosol, mitotic spindle, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, SIRT1 negatively regulates rRNA expression
UniProt: Q9H5J8
Entrez ID: 79101
|
Does Knockout of RBMXL1 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
RBMXL1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: RBMXL1 (RBMX like 1)
Type: protein-coding
Summary: This gene represents a retrogene of RNA binding motif protein, X-linked (RBMX), which is located on chromosome X. While all introns in the coding sequence have been processed out compared to the RBMX locus, the ORF is intact and there is specific evidence for transcription at this location. The preservation of the ORF by purifying selection in all Old World monkeys carrying it suggests that this locus is likely to be functional, possibly during male meiosis when X chromosomal genes are silenced or during haploid stages of spermatogenesis. This gene shares 5' exon structure with the cysteine conjugate-beta lyase 2 locus on chromosome 1, but the coding sequences are non-overlapping. Alternative splicing results in two transcript variants. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: RNA splicing, mRNA processing, positive regulation of mRNA splicing, via spliceosome; MF: RNA binding, nucleic acid binding; CC: nucleus, organelle, ribonucleoprotein complex, spliceosomal complex
Pathways: Spliceosome - Homo sapiens (human)
UniProt: Q96E39
Entrez ID: 494115
|
Does Knockout of MRGBP in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
MRGBP
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MRGBP (MRG domain binding protein)
Type: protein-coding
Summary: Predicted to be involved in histone acetylation and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair, regulation of transcription by RNA polymerase II; CC: H4/H2A histone acetyltransferase complex, NuA4 histone acetyltransferase complex, nucleoplasm, nucleosome, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9NV56
Entrez ID: 55257
|
Does Knockout of SCG3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
SCG3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: SCG3 (secretogranin III)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: protein localization to secretory granule; MF: RNA binding, protein binding; CC: cytoplasmic vesicle, endoplasmic reticulum lumen, extracellular region, membrane, secretory granule lumen, secretory granule membrane, transport vesicle, transport vesicle membrane
Pathways: Hemostasis, Metabolism of proteins, Platelet activation, signaling and aggregation, Platelet degranulation , Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Response to elevated platelet cytosolic Ca2+
UniProt: Q8WXD2
Entrez ID: 29106
|
Does Knockout of BCL6 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
BCL6
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: BCL6 (BCL6 transcription repressor)
Type: protein-coding
Summary: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: B cell differentiation, B cell proliferation, DNA damage response, Rho protein signal transduction, T-helper 2 cell differentiation, actin cytoskeleton organization, cell morphogenesis, cell motility, cell population proliferation, cell-matrix adhesion, erythrocyte development, germinal center formation, heterochromatin formation, immune system process, inflammatory response, intracellular protein localization, isotype switching to IgE isotypes, mononuclear cell proliferation, negative regulation of B cell apoptotic process, negative regulation of DNA-templated transcription, negative regulation of Notch signaling pathway, negative regulation of Rho protein signal transduction, negative regulation of T-helper 2 cell differentiation, negative regulation of apoptotic process, negative regulation of cell growth, negative regulation of cell-matrix adhesion, negative regulation of cellular senescence, negative regulation of isotype switching to IgE isotypes, negative regulation of mast cell cytokine production, negative regulation of mitotic cell cycle DNA replication, negative regulation of mononuclear cell proliferation, negative regulation of plasma cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of type 2 immune response, plasma cell differentiation, positive regulation of B cell proliferation, positive regulation of apoptotic process, positive regulation of cell differentiation, positive regulation of cell motility, positive regulation of lymphocyte activation, positive regulation of neuron differentiation, positive regulation of regulatory T cell differentiation, pyramidal neuron differentiation, regulation of T cell differentiation, regulation of T cell proliferation, regulation of apoptotic process, regulation of cell differentiation, regulation of cell population proliferation, regulation of cytokine production, regulation of germinal center formation, regulation of immune response, regulation of immune system process, regulation of inflammatory response, regulation of leukocyte cell-cell adhesion, regulation of memory T cell differentiation, regulation of transcription by RNA polymerase II, spermatogenesis, transcription by RNA polymerase II, type 2 immune response; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, identical protein binding, intronic transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription corepressor binding, zinc ion binding; CC: Golgi apparatus, nucleolus, nucleoplasm, nucleus, paraspeckles, replication fork
Pathways: B Cell Receptor Signaling Pathway, BCR, Cytokine Signaling in Immune system, DNA damage response (only ATM dependent), Direct p53 effectors, FBXL10 enhancement of MAP-ERK signaling in diffuse large B-cell lymphoma, FOXO-mediated transcription, FOXO-mediated transcription of cell death genes, FoxO family signaling, FoxO signaling pathway - Homo sapiens (human), Gene expression (Transcription), Generic Transcription Pathway, IL4-mediated signaling events, Immune System, Interleukin-4 and Interleukin-13 signaling, MECP2 and Associated Rett Syndrome, RNA Polymerase II Transcription, Signaling by Interleukins, Signaling events mediated by HDAC Class II, TP53 Regulates Transcription of Cell Death Genes, TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, Transcriptional Regulation by TP53, Transcriptional misregulation in cancer - Homo sapiens (human), Vitamin D Receptor Pathway
UniProt: P41182
Entrez ID: 604
|
Does Knockout of FCF1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
FCF1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: FCF1 (FCF1 rRNA-processing protein)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Predicted to act upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding; CC: nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y324
Entrez ID: 51077
|
Does Knockout of ARSF in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
ARSF
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: ARSF (arylsulfatase F)
Type: protein-coding
Summary: This gene is a member of the sulfatase family, and more specifically, the arylsulfatase subfamily. Members of the subfamily share similarity in sequence and splice sites, and are clustered together on chromosome X, suggesting that they are derived from recent gene duplication events. Sulfatases are essential for the correct composition of bone and cartilage matrix. The activity of this protein, unlike that of arylsulfatase E, is not inhibited by warfarin. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jan 2011].
Gene Ontology: MF: arylsulfatase activity, hydrolase activity, metal ion binding; CC: endoplasmic reticulum lumen, extracellular exosome, extracellular region
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Metabolism of proteins, Post-translational protein modification, Sphingolipid metabolism, The activation of arylsulfatases
UniProt: P54793
Entrez ID: 416
|
Does Knockout of RAB10 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
RAB10
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: RAB10 (RAB10, member RAS oncogene family)
Type: protein-coding
Summary: RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009].
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi to plasma membrane transport, antigen processing and presentation, axonogenesis, cell-cell adhesion, cellular response to insulin stimulus, endoplasmic reticulum tubular network organization, endosomal transport, establishment of neuroblast polarity, establishment of protein localization to endoplasmic reticulum membrane, establishment of protein localization to membrane, exocytosis, polarized epithelial cell differentiation, protein localization to basolateral plasma membrane, protein localization to plasma membrane, protein transport, regulated exocytosis, vesicle-mediated transport; MF: G protein activity, GDP binding, GTP binding, GTPase activity, cadherin binding involved in cell-cell adhesion, hydrolase activity, myosin V binding, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi membrane, adherens junction, cell projection, cilium, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytoskeleton, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum tubular network, endosome, endosome membrane, exocyst, exocytic vesicle, extracellular exosome, focal adhesion, insulin-responsive compartment, lysosome, membrane, perinuclear region of cytoplasm, phagocytic vesicle membrane, plasma membrane, recycling endosome, recycling endosome membrane, secretory granule membrane, secretory vesicle, trans-Golgi network
Pathways: AMPK signaling pathway - Homo sapiens (human), Endocytosis - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Immune System, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Translocation of SLC2A4 (GLUT4) to the plasma membrane, Vesicle-mediated transport
UniProt: P61026
Entrez ID: 10890
|
Does Knockout of SPINK5 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
SPINK5
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: SPINK5 (serine peptidase inhibitor Kazal type 5)
Type: protein-coding
Summary: This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: cell differentiation, epidermal cell differentiation, epithelial cell differentiation, extracellular matrix organization, hair cell differentiation, negative regulation of angiogenesis, negative regulation of antibacterial peptide production, negative regulation of immune response, negative regulation of proteolysis, regulation of T cell differentiation, regulation of cell adhesion, regulation of timing of anagen; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: cell cortex, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, epidermal lamellar body, extracellular region, perinuclear region of cytoplasm
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin, Formation of the cornified envelope, Keratinization
UniProt: Q9NQ38
Entrez ID: 11005
|
Does Knockout of ZNF736 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
ZNF736
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ZNF736 (zinc finger protein 736)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: B4DX44
Entrez ID: 728927
|
Does Knockout of MRPL32 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
MRPL32
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: MRPL32 (mitochondrial ribosomal protein L32)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial matrix, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9BYC8
Entrez ID: 64983
|
Does Knockout of CEP44 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
CEP44
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: CEP44 (centrosomal protein 44)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in centriole replication and centriole-centriole cohesion. Located in centriole; centrosome; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: centriole replication, centriole-centriole cohesion, centrosome cycle; MF: microtubule binding, protein binding; CC: centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, midbody, spindle pole
Pathways: Genes related to primary cilium development (based on CRISPR)
UniProt: Q9C0F1
Entrez ID: 80817
|
Does Knockout of CCDC186 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
CCDC186
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: CCDC186 (coiled-coil domain containing 186)
Type: protein-coding
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in vesicle cytoskeletal trafficking. Predicted to act upstream of or within insulin secretion involved in cellular response to glucose stimulus and response to bacterium. Predicted to be located in Golgi apparatus. Predicted to be active in trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: glucose homeostasis, insulin secretion involved in cellular response to glucose stimulus, response to bacterium, vesicle cytoskeletal trafficking; CC: Golgi apparatus, trans-Golgi network
Pathways:
UniProt: Q7Z3E2
Entrez ID: 55088
|
Does Knockout of MRPL33 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
MRPL33
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MRPL33 (mitochondrial ribosomal protein L33)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; CC: cytoplasm, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: O75394
Entrez ID: 9553
|
Does Knockout of C3orf38 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
C3orf38
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: C3orf38 (chromosome 3 open reading frame 38)
Type: protein-coding
Summary: Involved in positive regulation of apoptotic process. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, positive regulation of apoptotic process
Pathways:
UniProt: Q5JPI3
Entrez ID: 285237
|
Does Knockout of FCAMR in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
FCAMR
|
cell proliferation
|
Cancer Cell Line
|
Gene: FCAMR (Fc alpha and mu receptor)
Type: protein-coding
Summary: Predicted to enable IgA binding activity; IgM binding activity; and transmembrane signaling receptor activity. Predicted to be involved in adaptive immune response. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: adaptive immune response, immune system process, signal transduction; CC: membrane, plasma membrane
Pathways: Cell surface interactions at the vascular wall, Hemostasis
UniProt: Q8WWV6
Entrez ID: 83953
|
Does Knockout of MAT1A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
MAT1A
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: MAT1A (methionine adenosyltransferase 1A)
Type: protein-coding
Summary: This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: L-methionine catabolic process, S-adenosylmethionine biosynthetic process, one-carbon metabolic process, protein complex oligomerization, protein homotetramerization; MF: ATP binding, identical protein binding, metal ion binding, methionine adenosyltransferase activity, nucleotide binding, protein binding, transferase activity; CC: cytosol, methionine adenosyltransferase complex
Pathways: Biological oxidations, Cysteine and methionine metabolism - Homo sapiens (human), Defective MAT1A causes MATD, Disease, Diseases of metabolism, Ethanol effects on histone modifications, Folate Metabolism, Metabolic disorders of biological oxidation enzymes, Metabolism, Metabolism of amino acids and derivatives, Metabolism of ingested SeMet, Sec, MeSec into H2Se, Methionine De Novo and Salvage Pathway, Methylation, Methylation Pathways, One-carbon metabolism, One-carbon metabolism and related pathways, Phase II - Conjugation of compounds, S-adenosyl-L-methionine biosynthesis, Selenoamino acid metabolism, Sulfur amino acid metabolism, Trans-sulfuration and one-carbon metabolism, Vitamin B12 metabolism, cysteine biosynthesis, methionine degradation, superpathway of methionine degradation
UniProt: Q00266
Entrez ID: 4143
|
Does Knockout of VMP1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
VMP1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: VMP1 (vacuole membrane protein 1)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: Golgi organization, autophagosome assembly, autophagosome membrane docking, autophagy, cell adhesion, cell junction assembly, cell-cell adhesion, embryo implantation, lipid transport, lipoprotein transport, mitochondrion-endoplasmic reticulum membrane tethering, organelle localization by membrane tethering, plasma membrane phospholipid scrambling, positive regulation of ATPase-coupled calcium transmembrane transporter activity; MF: phospholipid scramblase activity, protein binding; CC: autophagosome membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, nucleolus, phagophore assembly site, plasma membrane, vacuolar membrane, vacuole
Pathways: Autophagy - animal - Homo sapiens (human), Nanoparticle triggered autophagic cell death
UniProt: Q96GC9
Entrez ID: 81671
|
Does Knockout of ZMYND8 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
ZMYND8
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ZMYND8 (zinc finger MYND-type containing 8)
Type: protein-coding
Summary: The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin organization, double-strand break repair via homologous recombination, modulation of excitatory postsynaptic potential, negative regulation of DNA-templated transcription, negative regulation of cell migration, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of dendritic spine development, positive regulation of dendritic spine maintenance, positive regulation of filopodium assembly, positive regulation of transcription elongation by RNA polymerase II, protein localization to chromatin, regulation of DNA-templated transcription, regulation of postsynaptic density protein 95 clustering; MF: DNA-binding transcription factor binding, histone H3K14ac reader activity, histone H3K4me1 reader activity, metal ion binding, protein binding, protein domain specific binding, transcription corepressor activity, zinc ion binding; CC: chromatin, chromosome, cytoplasm, dendritic shaft, dendritic spine, nucleolus, nucleoplasm, nucleus, site of DNA damage
Pathways:
UniProt: Q9ULU4
Entrez ID: 23613
|
Does Knockout of SPC24 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
SPC24
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SPC24 (SPC24 component of NDC80 kinetochore complex)
Type: protein-coding
Summary: Predicted to be involved in cell division. Located in nucleolus and nucleoplasm. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, mitotic spindle assembly checkpoint signaling; MF: microtubule binding, protein binding; CC: Ndc80 complex, chromosome, chromosome, centromeric region, cytosol, kinetochore, nucleolus, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, PLK1 signaling events, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8NBT2
Entrez ID: 147841
|
Does Knockout of STAT3 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
STAT3
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: STAT3 (signal transducer and activator of transcription 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: T-helper 17 cell lineage commitment, T-helper 17 type immune response, acute-phase response, astrocyte differentiation, canonical NF-kappaB signal transduction, cell differentiation, cell population proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, cellular response to cytokine stimulus, cellular response to hormone stimulus, cellular response to interleukin-17, cellular response to leptin stimulus, cytokine-mediated signaling pathway, defense response, eating behavior, energy homeostasis, eye photoreceptor cell differentiation, gene expression, glucose homeostasis, growth hormone receptor signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, immune response, inflammatory response, inflammatory response to wounding, interleukin-10-mediated signaling pathway, interleukin-11-mediated signaling pathway, interleukin-15-mediated signaling pathway, interleukin-2-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-6-mediated signaling pathway, interleukin-9-mediated signaling pathway, intracellular receptor signaling pathway, leptin-mediated signaling pathway, mRNA transcription by RNA polymerase II, modulation of chemical synaptic transmission, negative regulation of 3'-UTR-mediated mRNA stabilization, negative regulation of autophagy, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cell population proliferation, negative regulation of cytokine production involved in inflammatory response, negative regulation of gene expression, negative regulation of glycolytic process, negative regulation of hydrogen peroxide biosynthetic process, negative regulation of inflammatory response, negative regulation of inflammatory response to wounding, negative regulation of neuron migration, negative regulation of primary miRNA processing, negative regulation of stem cell differentiation, negative regulation of transcription by RNA polymerase II, nervous system development, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphorylation, positive regulation of ATP biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of Notch signaling pathway, positive regulation of angiogenesis, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cytokine production involved in inflammatory response, positive regulation of erythrocyte differentiation, positive regulation of extracellular matrix disassembly, positive regulation of gene expression, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, positive regulation of inflammatory response, positive regulation of interleukin-1 beta production, positive regulation of interleukin-10 production, positive regulation of interleukin-6 production, positive regulation of interleukin-8 production, positive regulation of miRNA transcription, positive regulation of multicellular organismal process, positive regulation of phagocytosis, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of vascular endothelial cell proliferation, positive regulation of vascular endothelial growth factor production, postsynapse to nucleus signaling pathway, protein import into nucleus, radial glial cell differentiation, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell population proliferation, regulation of cellular response to hypoxia, regulation of cytokine production, regulation of feeding behavior, regulation of mitochondrial membrane permeability, regulation of multicellular organism growth, regulation of transcription by RNA polymerase II, response to cytokine, response to estradiol, response to ethanol, response to hypoxia, response to ischemia, response to leptin, response to peptide hormone, retinal rod cell differentiation, sexual reproduction, signal transduction, signal transduction involved in regulation of gene expression, somatic stem cell population maintenance, temperature homeostasis, transcription by RNA polymerase II, transforming growth factor beta receptor signaling pathway; MF: CCR5 chemokine receptor binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, RNA sequestering activity, chromatin DNA binding, identical protein binding, lncRNA binding, nuclear glucocorticoid receptor binding, nuclear receptor activity, primary miRNA binding, protein binding, protein dimerization activity, protein homodimerization activity, protein kinase binding, protein phosphatase binding, protein sequestering activity, sequence-specific DNA binding, signaling adaptor activity, signaling receptor binding, transcription cis-regulatory region binding; CC: RNA polymerase II transcription regulator complex, Schaffer collateral - CA1 synapse, chromatin, cytoplasm, cytosol, glutamatergic synapse, mitochondrial inner membrane, nucleoplasm, nucleus, plasma membrane, postsynaptic density, protein-containing complex, transcription regulator complex
Pathways: AGE-RAGE pathway, AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Acute myeloid leukemia - Homo sapiens (human), Acute viral myocarditis, Adipocytokine signaling pathway - Homo sapiens (human), Adipogenesis, Androgen receptor signaling pathway, AndrogenReceptor, BCR, Brain-derived neurotrophic factor (BDNF) signaling pathway, CXCR4-mediated signaling events, Cancer immunotherapy by PD-1 blockade, Cell Differentiation - Index, Cell Differentiation - Index expanded, Cell migration and invasion through p75NTR, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Coronavirus disease - COVID-19 - Homo sapiens (human), Development of pulmonary dendritic cells and macrophage subsets, Dopaminergic Neurogenesis, EGF-EGFR signaling pathway, EGFR Tyrosine Kinase Inhibitor Resistance, EGFR1, EPO Receptor Signaling, ESC Pluripotency Pathways, Epstein-Barr virus infection - Homo sapiens (human), ErbB1 downstream signaling, ErbB2/ErbB3 signaling events, Estrogen Receptor Pathway, Extracellular vesicles in the crosstalk of cardiac cells, FGF signaling pathway, FOXP3 in COVID-19, Fibroblast growth factor-1, FoxO signaling pathway - Homo sapiens (human), GMCSF-mediated signaling events, Gastrin, Gastrin signaling pathway, Growth hormone synthesis, secretion and action - Homo sapiens (human), HIF-1 signaling pathway - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Hepatitis C and Hepatocellular Carcinoma, Human cytomegalovirus infection - Homo sapiens (human), IL-10 Anti-inflammatory Signaling Pathway, IL-2 signaling pathway, IL-3 signaling pathway, IL-4 signaling pathway, IL-5 signaling pathway, IL-6 signaling pathway, IL-7, IL-7 signaling pathway, IL-9 signaling pathway, IL11, IL12 signaling mediated by STAT4, IL12-mediated signaling events, IL17 signaling pathway, IL2, IL2-mediated signaling events, IL23-mediated signaling events, IL27-mediated signaling events, IL4, IL5, IL6, IL6-mediated signaling events, IL9, Inflammatory bowel disease - Homo sapiens (human), Insulin resistance - Homo sapiens (human), Interactions between immune cells and microRNAs in tumor microenvironment, Interferon type I signaling pathways, Interleukin-11 Signaling Pathway, JAK-STAT signaling pathway - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Kit receptor signaling pathway, KitReceptor, Leptin, Leptin Insulin Overlap, Leptin signaling pathway, Lipid and atherosclerosis - Homo sapiens (human), Mammary gland development pathway - Involution (Stage 4 of 4), Measles - Homo sapiens (human), MicroRNAs in cancer - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, Necroptosis - Homo sapiens (human), Neural Crest Cell Migration during Development, Neural Crest Cell Migration in Cancer, Neurotrophic factor-mediated Trk receptor signaling, Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Notch, Notch Signaling Pathway Netpath, Notch-mediated HES/HEY network, Nuclear Receptors Meta-Pathway, Oncostatin M Signaling Pathway, Oncostatin_M, PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), PDGFR-beta signaling pathway, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pathways in clear cell renal cell carcinoma, Physiological and pathological hypertrophy of the heart, Prion disease pathway, Prolactin, Prolactin Signaling Pathway, Prolactin signaling pathway - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAC1 signaling pathway, RAC1-PAK1-p38-MMP2 Pathway, RAGE, Regulation of Microtubule Cytoskeleton, Regulatory circuits of the STAT3 signaling pathway, Serotonin Receptor 2 and STAT3 Signaling, Signaling events mediated by HDAC Class I, Signaling events mediated by PTP1B, Signaling events mediated by Stem cell factor receptor (c-Kit), Signaling events mediated by TCPTP, Signaling of Hepatocyte Growth Factor Receptor, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer, TFs regulate miRNAs related to cardiac hypertrophy, TGF-beta Receptor Signaling, TGF-beta receptor signaling in skeletal dysplasias, TSLP, Th17 cell differentiation - Homo sapiens (human), Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, Thyroid stimulating hormone (TSH) signaling pathway, Toxoplasmosis - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, Viral carcinogenesis - Homo sapiens (human), bioactive peptide induced signaling pathway, egf signaling pathway, erk1/erk2 mapk signaling pathway, il 6 signaling pathway, il22 soluble receptor signaling pathway, mBDNF and proBDNF regulation of GABA neurotransmission, ncRNAs involved in STAT3 signaling in hepatocellular carcinoma, pdgf signaling pathway, role of erbb2 in signal transduction and oncology, stat3 signaling pathway, tpo signaling pathway
UniProt: P40763
Entrez ID: 6774
|
Does Knockout of WNT7A in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
WNT7A
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: WNT7A (Wnt family member 7A)
Type: protein-coding
Summary: This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Wnt signaling pathway, Wnt signaling pathway, planar cell polarity pathway, angiogenesis, animal organ development, apoptotic process, asymmetric protein localization involved in cell fate determination, axonogenesis, canonical Wnt signaling pathway, cartilage condensation, cartilage development, cell differentiation, cell fate commitment, cell proliferation in forebrain, cellular response to transforming growth factor beta stimulus, central nervous system vasculogenesis, cerebellar granule cell differentiation, chondrocyte differentiation, dendritic spine morphogenesis, dorsal/ventral pattern formation, embryonic axis specification, embryonic digit morphogenesis, embryonic forelimb morphogenesis, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, establishment of blood-brain barrier, establishment of cell polarity, excitatory synapse assembly, lens fiber cell development, limb development, negative regulation of apoptotic process, negative regulation of neurogenesis, neuron differentiation, neurotransmitter secretion, non-canonical Wnt signaling pathway, oviduct development, positive regulation of DNA-templated transcription, positive regulation of JNK cascade, positive regulation of cell population proliferation, positive regulation of endothelial cell migration, positive regulation of epithelial cell proliferation involved in wound healing, positive regulation of excitatory postsynaptic potential, positive regulation of excitatory synapse assembly, positive regulation of gene expression, positive regulation of protein localization to presynapse, positive regulation of protein metabolic process, positive regulation of synapse assembly, positive regulation of transcription by RNA polymerase II, postsynapse assembly, presynapse assembly, regulation of axon diameter, regulation of axonogenesis, regulation of cell population proliferation, regulation of epithelial cell proliferation, regulation of postsynapse organization, regulation of presynapse assembly, regulation of synaptic vesicle exocytosis, response to estradiol, response to estrogen, secondary palate development, sex differentiation, skeletal muscle satellite cell activation, skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration, somatic stem cell division, somatic stem cell population maintenance, stem cell development, synapse assembly, synapse organization, synaptic vesicle recycling, system development, tissue development, uterus development, uterus morphogenesis, wound healing, spreading of epidermal cells; MF: cytokine activity, frizzled binding, protein binding, receptor ligand activity, signaling receptor binding; CC: Golgi lumen, Schaffer collateral - CA1 synapse, cell surface, endocytic vesicle membrane, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix, extracellular region, extracellular space, glutamatergic synapse, plasma membrane, presynapse
Pathways: Alzheimer disease - Homo sapiens (human), Basal cell carcinoma - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, Class B/2 (Secretin family receptors), Cushing syndrome - Homo sapiens (human), DNA damage response (only ATM dependent), ESC Pluripotency Pathways, Epithelial to mesenchymal transition in colorectal cancer, GPCR ligand binding, Gastric cancer - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), LncRNA involvement in canonical Wnt signaling and colorectal cancer, Melanogenesis - Homo sapiens (human), Osteoblast differentiation, Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), WNT ligand biogenesis and trafficking, Wnt, Wnt signaling, Wnt signaling in kidney disease, Wnt signaling network, Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, mTOR signaling pathway - Homo sapiens (human), ncRNAs involved in Wnt signaling in hepatocellular carcinoma
UniProt: O00755
Entrez ID: 7476
|
Does Knockout of GCDH in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
GCDH
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: GCDH (glutaryl-CoA dehydrogenase)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: L-tryptophan metabolic process, acyl-CoA metabolic process, fatty acid beta-oxidation using acyl-CoA dehydrogenase, fatty acid oxidation, fatty-acyl-CoA biosynthetic process; MF: acyl-CoA dehydrogenase activity, fatty-acyl-CoA binding, flavin adenine dinucleotide binding, glutaryl-CoA dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors; CC: mitochondrial matrix, mitochondrion
Pathways: 2-aminoadipic 2-oxoadipic aciduria, Carnitine palmitoyl transferase deficiency (I), Carnitine palmitoyl transferase deficiency (II), Ethylmalonic Encephalopathy, Fatty acid Metabolism, Fatty acid beta-oxidation, Fatty acid degradation - Homo sapiens (human), Glutaric Aciduria Type I, Hyperlysinemia I, Familial, Hyperlysinemia II or Saccharopinuria, Long chain acyl-CoA dehydrogenase deficiency (LCAD), Lysine Degradation, Lysine catabolism, Lysine degradation - Homo sapiens (human), Medium chain acyl-coa dehydrogenase deficiency (MCAD), Metabolism, Metabolism of amino acids and derivatives, Pyridoxine dependency with seizures, Saccharopinuria/Hyperlysinemia II, Short Chain Acyl CoA Dehydrogenase Deficiency (SCAD Deficiency), Trifunctional protein deficiency, Tryptophan metabolism, Tryptophan metabolism - Homo sapiens (human), Very-long-chain acyl coa dehydrogenase deficiency (VLCAD), glutaryl-CoA degradation
UniProt: Q92947
Entrez ID: 2639
|
Does Knockout of NXF1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
NXF1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: NXF1 (nuclear RNA export factor 1)
Type: protein-coding
Summary: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA export from nucleus, mRNA export from nucleus, mRNA transport, poly(A)+ mRNA export from nucleus, protein transport; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, nuclear RNA export factor complex, nuclear envelope, nuclear inclusion body, nuclear pore, nuclear speck, nucleoplasm, nucleus, transcription export complex
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Influenza A - Homo sapiens (human), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9UBU9
Entrez ID: 10482
|
Does Knockout of RIF1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
RIF1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RIF1 (replication timing regulatory factor 1)
Type: protein-coding
Summary: This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to leukemia inhibitory factor, negative regulation of double-strand break repair via homologous recombination, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of isotype switching, somatic stem cell population maintenance, subtelomeric heterochromatin formation, telomere maintenance, telomere maintenance in response to DNA damage; CC: chromatin, chromosome, chromosome, telomeric region, chromosome, telomeric repeat region, condensed chromosome, cytoplasm, cytoskeleton, female pronucleus, male pronucleus, nuclear membrane, nucleoplasm, nucleus, plasma membrane, site of double-strand break, spindle, spindle midzone
Pathways: ATM Signaling Network in Development and Disease, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
UniProt: Q5UIP0
Entrez ID: 55183
|
Does Knockout of SRSF1 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
SRSF1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SRSF1 (serine and arginine rich splicing factor 1)
Type: protein-coding
Summary: This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014].
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, cardiac muscle contraction, cellular response to interleukin-17, in utero embryonic development, interleukin-17-mediated signaling pathway, liver regeneration, mRNA 5'-splice site recognition, mRNA processing, mRNA splice site recognition, mRNA splicing, via spliceosome, mRNA stabilization, mRNA transport, oligodendrocyte differentiation, positive regulation of RNA splicing, protein localization to P-body, protein localization to nucleus, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome, signal transduction involved in regulation of gene expression; MF: DNA topoisomerase binding, RNA binding, RS domain binding, mRNA binding, nucleic acid binding, protein binding, protein kinase B binding; CC: catalytic step 2 spliceosome, cytoplasm, exon-exon junction complex, nuclear envelope, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Gene expression (Transcription), Herpes simplex virus 1 infection - Homo sapiens (human), IL-17 signaling pathway - Homo sapiens (human), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q07955
Entrez ID: 6426
|
Does Knockout of TUSC1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
TUSC1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: TUSC1 (tumor suppressor candidate 1)
Type: protein-coding
Summary: This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways:
UniProt: Q2TAM9
Entrez ID: 286319
|
Does Knockout of ECD in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
ECD
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: ECD (ecdysoneless cell cycle regulator)
Type: protein-coding
Summary: Enables histone acetyltransferase binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, fibroblast proliferation, mRNA processing, positive regulation of transcription by RNA polymerase II, regulation of G1/S transition of mitotic cell cycle; MF: histone acetyltransferase binding, protein binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: O95905
Entrez ID: 11319
|
Does Knockout of CEP55 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
CEP55
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CEP55 (centrosomal protein 55)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Acts upstream of or within mitotic cytokinesis. Located in Flemming body; centriolar satellite; and plasma membrane. Implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, cranial skeletal system development, establishment of protein localization, midbody abscission, mitotic cytokinesis, mitotic metaphase chromosome alignment, nucleus organization, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: identical protein binding, protein binding; CC: Flemming body, centriole, centrosome, cleavage furrow, cytoplasm, cytoskeleton, intercellular bridge, membrane, midbody
Pathways:
UniProt: Q53EZ4
Entrez ID: 55165
|
Does Knockout of RPAP2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
RPAP2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RPAP2 (RNA polymerase II associated protein 2)
Type: protein-coding
Summary: Enables RNA polymerase II CTD heptapeptide repeat phosphatase activity. Involved in dephosphorylation of RNA polymerase II C-terminal domain and snRNA transcription. Located in cytosol and nucleolus. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: PERK-mediated unfolded protein response, regulation of transcription by RNA polymerase II, snRNA transcription; MF: RNA polymerase II CTD heptapeptide repeat phosphatase activity, RNA polymerase core enzyme binding, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity, zinc ion binding; CC: cilium, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, transcription preinitiation complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q8IXW5
Entrez ID: 79871
|
Does Knockout of TRA2B in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
TRA2B
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: TRA2B (transformer 2 beta homolog)
Type: protein-coding
Summary: This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, cellular response to glucose stimulus, cerebral cortex regionalization, embryonic brain development, mRNA processing, mRNA splicing, via spliceosome, positive regulation of mRNA splicing, via spliceosome, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, identical protein binding, mRNA binding, nucleic acid binding, pre-mRNA binding, protein binding, protein domain specific binding; CC: nuclear inner membrane, nucleoplasm, nucleus, protein-containing complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, RHOBTB2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P62995
Entrez ID: 6434
|
Does Knockout of TRAPPC13 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
TRAPPC13
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TRAPPC13 (trafficking protein particle complex subunit 13)
Type: protein-coding
Summary: Predicted to be located in cytosol. Predicted to be part of TRAPPIII protein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, vesicle coating, vesicle tethering; CC: TRAPPII protein complex, TRAPPIII protein complex, cytoplasm, cytosol
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: A5PLN9
Entrez ID: 80006
|
Does Knockout of ZDHHC6 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
ZDHHC6
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: ZDHHC6 (zDHHC palmitoyltransferase 6)
Type: protein-coding
Summary: Enables palmitoyltransferase activity. Involved in positive regulation of mitochondrial fusion and protein palmitoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intracellular signal transduction, protein targeting to membrane; MF: acyltransferase activity, palmitoyltransferase activity, protein binding, protein-cysteine S-palmitoyltransferase activity, protein-cysteine S-stearoyltransferase activity, transferase activity; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9H6R6
Entrez ID: 64429
|
Does Knockout of DHPS in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
DHPS
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: DHPS (deoxyhypusine synthase)
Type: protein-coding
Summary: This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011].
Gene Ontology: BP: glucose homeostasis, positive regulation of T cell proliferation, positive regulation of cell population proliferation, protein maturation, spermidine catabolic process, spermidine metabolic process, translation; MF: deoxyhypusine synthase activity, identical protein binding, protein binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification, hypusine biosynthesis
UniProt: P49366
Entrez ID: 1725
|
Does Knockout of NIP7 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
NIP7
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: NIP7 (nucleolar pre-rRNA processing protein NIP7)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome assembly, ribosome biogenesis; MF: RNA binding, protein binding; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y221
Entrez ID: 51388
|
Does Knockout of FOXD4 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
FOXD4
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: FOXD4 (forkhead box D4)
Type: protein-coding
Summary: This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA binding, bending, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: Q12950
Entrez ID: 2298
|
Does Activation of TXLNG in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
TXLNG
|
protein/peptide accumulation
|
T cell
|
Gene: TXLNG (taxilin gamma)
Type: protein-coding
Summary: This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
Gene Ontology: BP: regulation of bone mineralization, regulation of cell cycle, regulation of cell cycle process; MF: DNA-binding transcription factor binding, syntaxin binding; CC: cytoplasm, cytosol, membrane, nuclear membrane, nucleus
Pathways: Validated transcriptional targets of AP1 family members Fra1 and Fra2
UniProt: Q9NUQ3
Entrez ID: 55787
|
Does Knockout of ATP6V1D in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
ATP6V1D
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: ATP6V1D (ATPase H+ transporting V1 subunit D)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi lumen acidification, cell projection organization, cilium assembly, endosomal lumen acidification, intracellular pH reduction, lysosomal lumen acidification, monoatomic ion transport, protein localization to cilium, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification, vacuolar acidification; MF: protein binding, proton-transporting ATPase activity, rotational mechanism; CC: Golgi membrane, cell projection, centrosome, cilium, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, endosome membrane, extracellular exosome, extrinsic component of synaptic vesicle membrane, lysosomal membrane, membrane, nucleoplasm, plasma membrane, proton-transporting V-type ATPase complex, specific granule membrane, vacuolar proton-transporting V-type ATPase, V1 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Neutrophil degranulation, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, mTOR signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: Q9Y5K8
Entrez ID: 51382
|
Does Knockout of COPS3 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
COPS3
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: COPS3 (COP9 signalosome subunit 3)
Type: protein-coding
Summary: The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: in utero embryonic development, protein deneddylation, protein neddylation, regulation of DNA damage response, signal transduction by p53 class mediator, regulation of protein neddylation, response to light stimulus, signal transduction, ubiquitin-dependent protein catabolic process; CC: COP9 signalosome, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Cargo recognition for clathrin-mediated endocytosis, Ciliary landscape, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Post-translational protein modification, TNFalpha, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q9UNS2
Entrez ID: 8533
|
Does Knockout of OIT3 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
OIT3
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: OIT3 (oncoprotein induced transcript 3)
Type: protein-coding
Summary: This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016].
Gene Ontology: MF: calcium ion binding, protein binding; CC: cell surface, extracellular space, nuclear envelope, nucleus
Pathways:
UniProt: Q8WWZ8
Entrez ID: 170392
|
Does Knockout of SMG6 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
SMG6
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: SMG6 (SMG6 nonsense mediated mRNA decay factor)
Type: protein-coding
Summary: This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: mRNA export from nucleus, negative regulation of telomere capping, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of dephosphorylation, regulation of telomere maintenance, regulation of telomere maintenance via telomerase; MF: DNA binding, DNA polymerase binding, RNA binding, RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, protein binding, ribonucleoprotein complex binding, telomerase RNA binding, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, ciliary basal body, cytoplasm, cytosol, exon-exon junction complex, nucleolus, nucleus, plasma membrane, telomerase holoenzyme complex
Pathways: Metabolism of RNA, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Regulation of Telomerase, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q86US8
Entrez ID: 23293
|
Does Knockout of RPN2 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
RPN2
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: RPN2 (ribophorin II)
Type: protein-coding
Summary: This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: protein N-linked glycosylation, protein glycosylation, protein modification process; MF: dolichyl-diphosphooligosaccharide-protein glycotransferase activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear body, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Asparagine N-linked glycosylation, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Disease, Immune System, Infectious disease, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Proteasome Degradation, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation of Structural Proteins, Various types of N-glycan biosynthesis - Homo sapiens (human), Viral Infection Pathways, proteasome complex
UniProt: P04844
Entrez ID: 6185
|
Does Knockout of NYNRIN in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
NYNRIN
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: NYNRIN (NYN domain and retroviral integrase containing)
Type: protein-coding
Summary: Predicted to enable endoribonuclease activity and mRNA binding activity. Predicted to be involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Predicted to be integral component of membrane. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA integration, DNA synthesis involved in DNA repair, DNA-templated DNA replication, biological_process; MF: RNA endonuclease activity, RNA-DNA hybrid ribonuclease activity, mRNA binding, molecular_function, nucleic acid binding; CC: cellular_component, cytoplasmic ribonucleoprotein granule, membrane, nucleus
Pathways:
UniProt: Q9P2P1
Entrez ID: 57523
|
Does Knockout of THOC3 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
THOC3
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: THOC3 (THO complex subunit 3)
Type: protein-coding
Summary: This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013].
Gene Ontology: BP: RNA splicing, mRNA export from nucleus, mRNA processing, mRNA transport; CC: THO complex part of transcription export complex, chromosome, telomeric region, nuclear speck, nucleoplasm, nucleus, transcription export complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, RNA transport - Homo sapiens (human), Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q96J01
Entrez ID: 84321
|
Does Knockout of COASY in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
COASY
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: COASY (Coenzyme A synthase)
Type: protein-coding
Summary: Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: coenzyme A biosynthetic process; MF: ATP binding, catalytic activity, dephospho-CoA kinase activity, kinase activity, nucleotide binding, nucleotidyltransferase activity, pantetheine-phosphate adenylyltransferase activity, protein binding, transferase activity; CC: cytoplasm, extracellular exosome, mitochondrial matrix, mitochondrial outer membrane, mitochondrion
Pathways: Coenzyme A biosynthesis, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Pantothenate and CoA Biosynthesis, Pantothenate and CoA biosynthesis - Homo sapiens (human), Vitamin B5 (pantothenate) metabolism, coenzyme A biosynthesis
UniProt: Q13057
Entrez ID: 80347
|
Does Knockout of KRTAP1-4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
KRTAP1-4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: KRTAP1-4 (keratin associated protein 1-4)
Type: protein-coding
Summary: The main structural proteins of mammalian hair fiber are the hair keratins (see MIM 601077) and the keratin-associated proteins (KAPs), which form a rigid and resistant hair shaft through extensive disulfide bond crosslinking with the abundant cysteines of hair keratins (Shimomura et al., 2002 [PubMed 12228244]).[supplied by OMIM, Jan 2009].
Gene Ontology: CC: cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: P0C5Y4
Entrez ID: 728255
|
Does Knockout of NASP in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
NASP
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: NASP (nuclear autoantigenic sperm protein)
Type: protein-coding
Summary: This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: CENP-A containing chromatin assembly, DNA replication, DNA replication-dependent chromatin assembly, blastocyst development, male gonad development, nucleosome assembly, protein transport, response to testosterone; MF: histone binding, protein binding, protein-containing complex binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: P49321
Entrez ID: 4678
|
Does Knockout of TTI2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
TTI2
|
cell proliferation
|
Cancer Cell Line
|
Gene: TTI2 (TELO2 interacting protein 2)
Type: protein-coding
Summary: This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance. [provided by RefSeq, May 2013].
Gene Ontology: BP: positive regulation of DNA damage checkpoint, protein stabilization; CC: TTT Hsp90 cochaperone complex, nucleus
Pathways:
UniProt: Q6NXR4
Entrez ID: 80185
|
Does Knockout of LHX4 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
LHX4
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: LHX4 (LIM homeobox 4)
Type: protein-coding
Summary: This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: animal organ morphogenesis, apoptotic process, medial motor column neuron differentiation, motor neuron axon guidance, negative regulation of apoptotic process, neuron differentiation, placenta development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, methyl-CpG binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromatin, nucleus
Pathways: Axon guidance, Developmental Biology, Nervous system development, Regulation of expression of SLITs and ROBOs, Signaling by ROBO receptors
UniProt: Q969G2
Entrez ID: 89884
|
Does Knockout of RASSF1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
RASSF1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: RASSF1 (Ras association domain family member 1)
Type: protein-coding
Summary: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011].
Gene Ontology: BP: DNA damage response, Ras protein signal transduction, positive regulation of protein ubiquitination, protein stabilization, regulation of cell cycle, regulation of cell cycle G1/S phase transition, signal transduction; MF: identical protein binding, metal ion binding, protein binding, small GTPase binding, zinc ion binding; CC: centrosome, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, nucleus, spindle, spindle pole
Pathways: Bladder cancer, Bladder cancer - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Hippo signaling pathway - multiple species - Homo sapiens (human), Hippo-Yap signaling pathway, MicroRNAs in cancer - Homo sapiens (human), Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), p53 pathway
UniProt: Q9NS23
Entrez ID: 11186
|
Does Knockout of ETFDH in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
ETFDH
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ETFDH (electron transfer flavoprotein dehydrogenase)
Type: protein-coding
Summary: This gene encodes a component of the electron-transfer system in mitochondria and is essential for electron transfer from a number of mitochondrial flavin-containing dehydrogenases to the main respiratory chain. Mutations in this gene are associated with glutaric acidemia. Alternatively spliced transcript variants that encode distinct isoforms have been observed. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: electron transport chain, fatty acid beta-oxidation using acyl-CoA dehydrogenase, respiratory electron transport chain, response to oxidative stress; MF: 4 iron, 4 sulfur cluster binding, electron transfer activity, electron-transferring-flavoprotein dehydrogenase activity, flavin adenine dinucleotide binding, iron-sulfur cluster binding, metal ion binding, oxidoreductase activity, protein binding, quinone binding, ubiquinone binding; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Respiratory electron transport, Riboflavin and CoQ disorders
UniProt: Q16134
Entrez ID: 2110
|
Does Knockout of EBNA1BP2 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
EBNA1BP2
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: EBNA1BP2 (EBNA1 binding protein 2)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal large subunit biogenesis. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding; CC: chromosome, nuclear periphery, nucleolus, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q99848
Entrez ID: 10969
|
Does Knockout of CFDP1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
CFDP1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: CFDP1 (craniofacial development protein 1)
Type: protein-coding
Summary: Predicted to act upstream of or within several processes, including cell adhesion; negative regulation of fibroblast apoptotic process; and regulation of cell shape. Predicted to be located in kinetochore. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell adhesion, chromatin remodeling, fibroblast apoptotic process, negative regulation of fibroblast apoptotic process, regulation of cell population proliferation, regulation of cell shape; CC: Swr1 complex, chromosome, chromosome, centromeric region, kinetochore
Pathways:
UniProt: Q9UEE9
Entrez ID: 10428
|
Does Activation of NXT2 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
NXT2
|
protein/peptide accumulation
|
T cell
|
Gene: NXT2 (nuclear transport factor 2 like export factor 2)
Type: protein-coding
Summary: The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, poly(A)+ mRNA export from nucleus, protein transport; CC: cytoplasm, cytosol, nuclear RNA export factor complex, nuclear pore central transport channel, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Influenza A - Homo sapiens (human), RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9NPJ8
Entrez ID: 55916
|
Does Knockout of SMDT1 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
SMDT1
|
response to virus
|
Lung Cancer Cell Line
|
Gene: SMDT1 (single-pass membrane protein with aspartate rich tail 1)
Type: protein-coding
Summary: This gene encodes a core regulatory component of a calcium channel in the mitochondrial inner membrane. [provided by RefSeq, Apr 2017].
Gene Ontology: BP: calcium import into the mitochondrion, calcium ion transport, cellular response to calcium ion, cellular response to calcium ion starvation, mitochondrial calcium ion homeostasis, mitochondrial calcium ion transmembrane transport, monoatomic ion transport; MF: channel activator activity, protein binding, protein-macromolecule adaptor activity; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, nucleoplasm, uniplex complex
Pathways: Metabolism of proteins, Mitochondrial calcium ion transport, Mitochondrial protein degradation, Processing of SMDT1, Transport of small molecules
UniProt: Q9H4I9
Entrez ID: 91689
|
Does Knockout of AHR in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
AHR
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: AHR (aryl hydrocarbon receptor)
Type: protein-coding
Summary: The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: apoptotic process, blood vessel development, cellular response to 2,3,7,8-tetrachlorodibenzodioxine, cellular response to cAMP, cellular response to forskolin, cellular response to molecule of bacterial origin, circadian regulation of gene expression, intestinal epithelial structure maintenance, intracellular receptor signaling pathway, negative regulation of DNA-templated transcription, negative regulation of T cell mediated immune response to tumor cell, negative regulation of inflammatory response, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of B cell proliferation, regulation of DNA-templated transcription, regulation of adaptive immune response, regulation of gene expression, regulation of transcription by RNA polymerase II, response to toxic substance, response to xenobiotic stimulus, rhythmic process, xenobiotic metabolic process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, Hsp90 protein binding, RNA polymerase II-specific DNA-binding transcription factor binding, TBP-class protein binding, TFIID-class transcription factor complex binding, cis-regulatory region sequence-specific DNA binding, nuclear receptor activity, protein binding, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coactivator binding; CC: aryl hydrocarbon receptor complex, chromatin, cytoplasm, cytosol, cytosolic aryl hydrocarbon receptor complex, nuclear aryl hydrocarbon receptor complex, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: Adipogenesis, AndrogenReceptor, Aryl Hydrocarbon Receptor Netpath, Aryl Hydrocarbon Receptor Pathway, Aryl hydrocarbon receptor signalling, Biological oxidations, Cannabinoid receptor signaling, Cushing syndrome - Homo sapiens (human), Cytochrome P450 - arranged by substrate type, Development and heterogeneity of the ILC family, Endogenous sterols, Integrated breast cancer pathway, Male infertility, Metabolism, Metabolism of lipids, Nuclear Receptors Meta-Pathway, PPARA activates gene expression, Phase I - Functionalization of compounds, Regulation of lipid metabolism by PPARalpha, Th17 cell differentiation - Homo sapiens (human), Xenobiotics, ahr signal transduction pathway
UniProt: P35869
Entrez ID: 196
|
Does Knockout of FN1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
FN1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: FN1 (fibronectin 1)
Type: protein-coding
Summary: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: acute-phase response, angiogenesis, biological process involved in interaction with symbiont, blood coagulation, fibrin clot formation, calcium-independent cell-matrix adhesion, cell adhesion, cell-matrix adhesion, cell-substrate junction assembly, endodermal cell differentiation, endothelial cell migration, heart development, integrin activation, integrin-mediated signaling pathway, negative regulation of monocyte activation, negative regulation of transforming growth factor beta production, nervous system development, neural crest cell migration involved in autonomic nervous system development, positive regulation of axon extension, positive regulation of cell population proliferation, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of substrate-dependent cell migration, cell attachment to substrate, regulation of ERK1 and ERK2 cascade, regulation of cell shape, regulation of protein phosphorylation, response to muscle activity, response to wounding, substrate adhesion-dependent cell spreading, wound healing; MF: collagen binding, extracellular matrix structural constituent, heparin binding, identical protein binding, integrin binding, peptidase activator activity, protease binding, protein binding, proteoglycan binding, receptor ligand activity, signaling receptor binding; CC: apical plasma membrane, basement membrane, blood microparticle, endoplasmic reticulum lumen, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, extracellular matrix, extracellular region, extracellular space, fibrinogen complex, plasma membrane, platelet alpha granule lumen
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Alpha4 beta1 integrin signaling events, Alpha9 beta1 integrin signaling events, Amoebiasis - Homo sapiens (human), Angiopoietin receptor Tie2-mediated signaling, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Bacterial invasion of epithelial cells - Homo sapiens (human), Beta1 integrin cell surface interactions, Beta3 integrin cell surface interactions, Beta5 beta6 beta7 and beta8 integrin cell surface interactions, ECM-receptor interaction - Homo sapiens (human), Epithelial to mesenchymal transition in colorectal cancer, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IL-18 signaling pathway, Inflammatory Response Pathway, Integrins in angiogenesis, Mammary gland development pathway - Puberty (Stage 2 of 4), Overview of nanoparticle effects, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Senescence and Autophagy in Cancer, Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Syndecan-2-mediated signaling events, Syndecan-4-mediated signaling events, TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, TGF-beta Signaling Pathway, Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling, VEGFA-VEGFR2 Signaling Pathway, VEGFR3 signaling in lymphatic endothelium, Yersinia infection - Homo sapiens (human), miR-509-3p alteration of YAP1-ECM axis, miRNA targets in ECM and membrane receptors
UniProt: P02751
Entrez ID: 2335
|
Does Knockout of RPL35 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
RPL35
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RPL35 (ribosomal protein L35)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), translation; MF: RNA binding, mRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, large ribosomal subunit, membrane, nucleolus, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P42766
Entrez ID: 11224
|
Does Knockout of KIF3B in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
KIF3B
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: KIF3B (kinesin family member 3B)
Type: protein-coding
Summary: The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anterograde axonal transport, anterograde dendritic transport of neurotransmitter receptor complex, axo-dendritic transport, cilium assembly, determination of left/right symmetry, intraciliary transport, microtubule-based movement, mitotic centrosome separation, mitotic spindle assembly, mitotic spindle organization, opsin transport, plus-end-directed vesicle transport along microtubule, positive regulation of cytokinesis, protein-containing complex localization, vesicle-mediated transport; MF: ATP binding, ATP hydrolysis activity, intraciliary transport particle B binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein binding, small GTPase binding; CC: axon, axon cytoplasm, cell projection, centrosome, ciliary tip, cilium, cytoplasm, cytoskeleton, cytosol, dendrite, dendrite cytoplasm, dendritic spine, extracellular exosome, glutamatergic synapse, kinesin II complex, kinesin complex, membrane, microtubule, microtubule cytoskeleton, midbody, plus-end kinesin complex, postsynapse, spindle microtubule, synapse
Pathways: Adaptive Immune System, COPI-dependent Golgi-to-ER retrograde traffic, Cilium Assembly, Factors involved in megakaryocyte development and platelet production, Genes related to primary cilium development (based on CRISPR), Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Organelle biogenesis and maintenance, Translocation of SLC2A4 (GLUT4) to the plasma membrane, Vesicle-mediated transport
UniProt: O15066
Entrez ID: 9371
|
Does Knockout of POLR1E in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
POLR1E
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: POLR1E (RNA polymerase I subunit E)
Type: protein-coding
Summary: Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and RNA polymerase I general transcription initiation factor binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA-templated transcription, RNA polymerase I preinitiation complex assembly, nucleolar large rRNA transcription by RNA polymerase I, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase I promoter; MF: DNA binding, RNA polymerase I general transcription initiation factor binding, protein binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Positive epigenetic regulation of rRNA expression, Pyrimidine metabolism, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Homo sapiens (human), TNFalpha
UniProt: Q9GZS1
Entrez ID: 64425
|
Does Knockout of ZBTB43 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
ZBTB43
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ZBTB43 (zinc finger and BTB domain containing 43)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase III general transcription initiation factor binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: chromatin, nucleus
Pathways:
UniProt: O43298
Entrez ID: 23099
|
Does Knockout of LIMK1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
LIMK1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: LIMK1 (LIM domain kinase 1)
Type: protein-coding
Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011].
Gene Ontology: BP: Fc-gamma receptor signaling pathway involved in phagocytosis, Rho protein signal transduction, actin cytoskeleton organization, axon extension, nervous system development, positive regulation of actin filament bundle assembly, positive regulation of axon extension, positive regulation of stress fiber assembly, protein phosphorylation, signal transduction, stress fiber assembly; MF: ATP binding, heat shock protein binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, ubiquitin ligase inhibitor activity, ubiquitin protein ligase binding; CC: cell junction, cell projection, cytoplasm, cytoskeleton, cytosol, focal adhesion, glutamatergic synapse, lamellipodium, male germ cell nucleus, membrane, neuron projection, nuclear speck, nucleus, postsynapse
Pathways: Axon guidance, Axon guidance - Homo sapiens (human), CDC42 signaling events, CXCR4-mediated signaling events, Caspase Cascade in Apoptosis, Developmental Biology, EPH-Ephrin signaling, EPHB-mediated forward signaling, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, G13 Signaling Pathway, Human immunodeficiency virus 1 infection - Homo sapiens (human), Immune System, Innate Immune System, Leptin, Nervous system development, RAC1 signaling pathway, RHO GTPase Effectors, RHO GTPases Activate ROCKs, RHO GTPases activate PAKs, Regulation of Actin Cytoskeleton, Regulation of Microtubule Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, RhoA signaling pathway, Sema3A PAK dependent Axon repulsion, Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Semaphorin interactions, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, VEGFA-VEGFR2 Signaling Pathway, Yersinia infection - Homo sapiens (human), ccr3 signaling in eosinophils, rac1 cell motility signaling pathway, rho cell motility signaling pathway, role of mal in rho-mediated activation of srf
UniProt: P53667
Entrez ID: 3984
|
Does Knockout of SARAF in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
SARAF
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: SARAF (store-operated calcium entry associated regulatory factor)
Type: protein-coding
Summary: Involved in regulation of store-operated calcium entry. Located in endoplasmic reticulum and endoplasmic reticulum-plasma membrane contact site. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: calcium ion transport, monoatomic ion transport, regulation of store-operated calcium entry; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-plasma membrane contact site, membrane
Pathways:
UniProt: Q96BY9
Entrez ID: 51669
|
Does Knockout of ING4 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
ING4
|
response to virus
|
Lung Cancer Cell Line
|
Gene: ING4 (inhibitor of growth family member 4)
Type: protein-coding
Summary: This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication-dependent chromatin disassembly, apoptotic process, chromatin organization, chromatin remodeling, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of growth, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, protein acetylation, regulation of DNA biosynthetic process, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell cycle G2/M phase transition, regulation of cell growth; MF: histone H3K14 acetyltransferase activity, histone H3K4me3 reader activity, histone H4K12 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, metal ion binding, protein binding, transcription coactivator activity, zinc ion binding; CC: cytosol, histone acetyltransferase complex, intermediate filament cytoskeleton, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9UNL4
Entrez ID: 51147
|
Does Knockout of POLD2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
POLD2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: POLD2 (DNA polymerase delta 2, accessory subunit)
Type: protein-coding
Summary: This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA-templated DNA replication, error-prone translesion synthesis; MF: DNA binding, protein binding; CC: delta DNA polymerase complex, nucleoplasm, nucleus, zeta DNA polymerase complex
Pathways: Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination, Homologous recombination - Homo sapiens (human), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Pyrimidine metabolism, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P49005
Entrez ID: 5425
|
Does Knockout of CHTOP in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
CHTOP
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CHTOP (chromatin target of PRMT1)
Type: protein-coding
Summary: This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: chromatin remodeling, in utero embryonic development, mRNA export from nucleus, mRNA transport, positive regulation of ATP-dependent activity, positive regulation of helicase activity; MF: RNA binding, methyl-CpG binding, protein binding; CC: nuclear speck, nucleolus, nucleoplasm, nucleus, transcription export complex
Pathways:
UniProt: Q9Y3Y2
Entrez ID: 26097
|
Does Knockout of CXCR3 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
CXCR3
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: CXCR3 (C-X-C motif chemokine receptor 3)
Type: protein-coding
Summary: This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, T cell chemotaxis, adenylate cyclase-activating G protein-coupled receptor signaling pathway, angiogenesis, apoptotic process, calcium-mediated signaling, cell adhesion, cell chemotaxis, cell surface receptor signaling pathway, chemokine-mediated signaling pathway, chemotaxis, immune response, inflammatory response, negative regulation of angiogenesis, negative regulation of endothelial cell proliferation, negative regulation of execution phase of apoptosis, positive regulation of angiogenesis, positive regulation of cell population proliferation, positive regulation of chemotaxis, positive regulation of cytosolic calcium ion concentration, positive regulation of execution phase of apoptosis, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of transcription by RNA polymerase II, regulation of cell adhesion, regulation of leukocyte migration, signal transduction; MF: C-C chemokine binding, C-C chemokine receptor activity, C-X-C chemokine binding, C-X-C chemokine receptor activity, G protein-coupled receptor activity, chemokine binding, chemokine receptor activity, protein binding, signaling receptor activity; CC: cell surface, cytoplasm, external side of plasma membrane, membrane, plasma membrane
Pathways: CXCR3-mediated signaling events, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Cytokine-cytokine receptor interaction - Homo sapiens (human), Developmental Biology, Differentiation of T cells, Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells), GPCRs, Class A Rhodopsin-like, GPCRs, Other, Peptide GPCRs, Selective expression of chemokine receptors during T-cell polarization, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: P49682
Entrez ID: 2833
|
Does Knockout of TMCO1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
TMCO1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TMCO1 (transmembrane and coiled-coil domains 1)
Type: protein-coding
Summary: This locus encodes a transmembrane protein. Mutations at this locus have been associated with craniofacial dysmorphism, skeletal anomalies, and cognitive disability. Mutations at this locus have also been associated with open angle glaucoma blindness. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: ER overload response, calcium ion transmembrane transport, calcium ion transport, endoplasmic reticulum calcium ion homeostasis, monoatomic ion transmembrane transport, monoatomic ion transport, multi-pass transmembrane protein insertion into ER membrane, ossification; MF: calcium channel activity, protein binding, ribosome binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial membrane, mitochondrion, multi-pass translocon complex
Pathways:
UniProt: Q9UM00
Entrez ID: 54499
|
Does Knockout of POLR3A in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
POLR3A
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: POLR3A (RNA polymerase III subunit A)
Type: protein-coding
Summary: The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: DNA-templated transcription, defense response to virus, immune system process, innate immune response, positive regulation of gene expression, positive regulation of interferon-beta production, tRNA transcription by RNA polymerase III; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, DNA/RNA hybrid binding, chromatin binding, magnesium ion binding, metal ion binding, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase III complex, cytoplasm, cytosol, membrane, nucleoplasm, nucleus
Pathways: Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , Gene expression (Transcription), Immune System, Innate Immune System, Pyrimidine metabolism, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human)
UniProt: O14802
Entrez ID: 11128
|
Does Knockout of ABT1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
ABT1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ABT1 (activator of basal transcription 1)
Type: protein-coding
Summary: Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, small-subunit processome assembly, spinal cord motor neuron differentiation, transcription by RNA polymerase II; MF: DNA binding, RNA binding, nucleic acid binding, protein binding, transcription coactivator activity; CC: nucleolus, nucleus, transcription regulator complex
Pathways:
UniProt: Q9ULW3
Entrez ID: 29777
|
Does Knockout of MCM2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
MCM2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: MCM2 (minichromosome maintenance complex component 2)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: DNA replication, DNA replication initiation, apoptotic process, cellular response to interleukin-4, cochlea development, double-strand break repair via break-induced replication, mitotic DNA replication initiation, nucleosome assembly, regulation of DNA-templated DNA replication initiation; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, DNA replication origin binding, enzyme binding, helicase activity, histone binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity, zinc ion binding; CC: CMG complex, MCM complex, chromatin, chromosome, chromosome, telomeric region, cilium, cytoplasm, cytosol, nuclear chromosome, nuclear origin of replication recognition complex, nucleolus, nucleoplasm, nucleus
Pathways: ATR signaling pathway, Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Ciliary landscape, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA strand elongation, Developmental Biology, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, Unwinding of DNA, cdk regulation of dna replication
UniProt: P49736
Entrez ID: 4171
|
Does Knockout of KIF14 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
KIF14
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: KIF14 (kinesin family member 14)
Type: protein-coding
Summary: This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, activation of protein kinase activity, cell division, cell proliferation in forebrain, cerebellar Purkinje cell layer structural organization, cerebellar cortex development, cerebellar granular layer structural organization, cerebral cortex development, establishment of protein localization, hippocampus development, microtubule depolymerization, microtubule-based movement, mitotic metaphase chromosome alignment, negative regulation of apoptotic process, negative regulation of integrin activation, negative regulation of neuron apoptotic process, olfactory bulb development, positive regulation of cell population proliferation, positive regulation of cytokinesis, proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of G1/S transition of mitotic cell cycle, regulation of G2/M transition of mitotic cell cycle, regulation of Rap protein signal transduction, regulation of cell adhesion, regulation of cell growth, regulation of cell maturation, regulation of cell migration, regulation of myelination, regulation of neuron apoptotic process, substrate adhesion-dependent cell spreading; MF: ATP binding, ATP hydrolysis activity, PDZ domain binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein binding, protein kinase binding, tubulin binding; CC: Flemming body, cytoplasm, cytoskeleton, cytosol, kinesin complex, membrane, microtubule, midbody, nucleus, plasma membrane, spindle, spindle midzone
Pathways: RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate CIT, RND1 GTPase cycle, RND2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q15058
Entrez ID: 9928
|
Does Knockout of RPL5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
RPL5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPL5 (ribosomal protein L5)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18P family of ribosomal proteins and component of the 60S subunit. The encoded protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The encoded protein may also function to inhibit tumorigenesis through the activation of downstream tumor suppressors and the downregulation of oncoprotein expression. Mutations in this gene have been identified in patients with Diamond-Blackfan Anemia (DBA). This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: cytoplasmic translation, negative regulation of protein neddylation, negative regulation of ubiquitin protein ligase activity, negative regulation of ubiquitin-dependent protein catabolic process, positive regulation of gene expression, positive regulation of translation, protein stabilization, rRNA processing, regulation of signal transduction by p53 class mediator, ribosomal large subunit assembly, ribosomal large subunit biogenesis, translation; MF: 5S rRNA binding, RNA binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, protein binding, rRNA binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, VEGFA-VEGFR2 Signaling Pathway, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, p53 pathway, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46777
Entrez ID: 6125
|
Does Knockout of NSMCE1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
NSMCE1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: NSMCE1 (NSE1 component of SMC5/6 complex)
Type: protein-coding
Summary: Enables protein dimerization activity and ubiquitin protein ligase activity. Involved in positive regulation of response to DNA damage stimulus. Located in nucleoplasm. Part of Smc5-Smc6 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin looping, double-strand break repair via homologous recombination, protein sumoylation, regulation of telomere maintenance; MF: metal ion binding, protein binding, protein dimerization activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Smc5-Smc6 complex, chromosome, chromosome, centromeric region, chromosome, telomeric region, mitotic spindle pole, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q8WV22
Entrez ID: 197370
|
Does Knockout of RNF149 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
RNF149
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: RNF149 (ring finger protein 149)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to xenobiotic stimulus; negative regulation of MAPK cascade; and regulation of protein stability. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to xenobiotic stimulus, negative regulation of MAPK cascade, protein ubiquitination, regulation of protein stability, ubiquitin-dependent protein catabolic process; MF: metal ion binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, endoplasmic reticulum, late endosome, membrane
Pathways:
UniProt: Q8NC42
Entrez ID: 284996
|
Does Knockout of CKAP5 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
CKAP5
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CKAP5 (cytoskeleton associated protein 5)
Type: protein-coding
Summary: This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: RNA transport, cell division, centrosome cycle, centrosome duplication, establishment or maintenance of microtubule cytoskeleton polarity, microtubule depolymerization, microtubule polymerization, mitotic spindle organization, positive regulation of microtubule nucleation, protein-containing complex organization, spindle organization; MF: cadherin binding, microtubule binding, microtubule plus end polymerase, microtubule plus-end binding, protein binding, ribonucleoprotein complex binding, tubulin binding; CC: centrosome, chromosome, chromosome, centromeric region, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, kinetochore, membrane, microtubule cytoskeleton, microtubule plus-end, mitotic spindle, nucleolus, plasma membrane, protein-containing complex, spindle, spindle pole
Pathways: AURKA Activation by TPX2, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, Aurora A signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, EML4 and NUDC in mitotic spindle formation, G2/M Transition, Integrin-linked kinase signaling, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Organelle biogenesis and maintenance, RHO GTPase Effectors, RHO GTPases Activate Formins, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q14008
Entrez ID: 9793
|
Does Knockout of CWC22 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
CWC22
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: CWC22 (CWC22 spliceosome associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nuclear speck. Part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, regulation of mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: U2-type catalytic step 1 spliceosome, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, catalytic step 2 spliceosome, cytosol, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9HCG8
Entrez ID: 57703
|
Does Knockout of HMSD in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
HMSD
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: HMSD (histocompatibility minor serpin domain containing)
Type: protein-coding
Summary: This gene encodes a serpin-domain containing protein that may function as a serine protease inhibitor. This gene is primarily expressed in cells of myeloid lineage. A polymorphism in this gene may result in the expression a splice variant that encodes a minor histocompatibility antigen. [provided by RefSeq, Oct 2010].
Gene Ontology: BP: activation of immune response, cytolysis, positive regulation of type II interferon production; MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways:
UniProt: P0C7T4, A8MTL9
Entrez ID: 284293
|
Does Knockout of SLC12A7 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
SLC12A7
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: SLC12A7 (solute carrier family 12 member 7)
Type: protein-coding
Summary: Enables protein kinase binding activity. Predicted to be involved in several processes, including cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell volume homeostasis, cellular response to glucose stimulus, chemical synaptic transmission, chloride ion homeostasis, chloride transmembrane transport, monoatomic ion transport, potassium ion homeostasis, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, transmembrane transport; MF: chloride:monoatomic cation symporter activity, potassium:chloride symporter activity, protein binding, protein kinase binding, symporter activity, transmembrane transporter activity; CC: membrane, plasma membrane, protein-containing complex, synapse
Pathways: Collecting duct acid secretion - Homo sapiens (human), EGFR1
UniProt: Q9Y666
Entrez ID: 10723
|
Does Knockout of NPLOC4 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
NPLOC4
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: NPLOC4 (NPL4 homolog, ubiquitin recognition factor)
Type: protein-coding
Summary: Predicted to enable ATPase binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and proteolysis involved in cellular protein catabolic process. Located in nucleus. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERAD pathway, Golgi organization, negative regulation of RIG-I signaling pathway, negative regulation of type I interferon production, proteasome-mediated ubiquitin-dependent protein catabolic process, retrograde protein transport, ER to cytosol, ubiquitin-dependent protein catabolic process; MF: ATPase binding, K48-linked polyubiquitin modification-dependent protein binding, K63-linked polyubiquitin modification-dependent protein binding, metal ion binding, protein binding, protein-containing complex binding, ubiquitin binding, ubiquitin protein ligase binding, zinc ion binding; CC: UFD1-NPL4 complex, VCP-NPL4-UFD1 AAA ATPase complex, cytoplasm, cytosol, endoplasmic reticulum, nuclear outer membrane-endoplasmic reticulum membrane network, nucleoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, DNA Damage Bypass, DNA Repair, KEAP1-NFE2L2 pathway, Metabolism of proteins, Neddylation, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, Translation, Translesion Synthesis by POLH, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q8TAT6
Entrez ID: 55666
|
Does Knockout of TIMM13 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
TIMM13
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: TIMM13 (translocase of inner mitochondrial membrane 13)
Type: protein-coding
Summary: This gene encodes a member of the evolutionarily conserved TIMM (translocase of inner mitochondrial membrane) family of proteins that function as chaperones in the import of proteins from the cytoplasm into the mitochondrial inner membrane. Proteins of this family play a role in collecting substrate proteins from the translocase of the outer mitochondrial membrane (TOM) complex and delivering them to either the sorting and assembly machinery in the outer mitochondrial membrane (SAM) complex or the TIMM22 complex in the inner mitochondrial membrane. The encoded protein and the translocase of mitochondrial inner membrane 8a protein form a 70 kDa complex in the intermembrane space. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: protein insertion into mitochondrial inner membrane, protein targeting to mitochondrion, protein transport, sensory perception of sound; MF: metal ion binding, protein binding, zinc ion binding; CC: fibrillar center, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial intermembrane space chaperone complex, mitochondrion
Pathways: Mitochondrial protein import, Protein localization
UniProt: Q9Y5L4
Entrez ID: 26517
|
Does Knockout of TTK in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
TTK
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: TTK (TTK protein kinase)
Type: protein-coding
Summary: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009].
Gene Ontology: BP: chromosome segregation, female meiosis chromosome segregation, meiotic spindle assembly checkpoint signaling, mitotic spindle assembly checkpoint signaling, mitotic spindle organization, nuclear chromosome segregation, nuclear division, positive regulation of SMAD protein signal transduction, positive regulation of cell population proliferation, protein localization to chromosome, protein localization to kinetochore, protein localization to meiotic spindle midzone, repair of mitotic kinetochore microtubule attachment defect, spindle organization; MF: ATP binding, identical protein binding, kinase activity, kinetochore binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, kinetochore, membrane, nucleus, spindle
Pathways: Cell cycle, Cell cycle - Homo sapiens (human), Retinoblastoma gene in cancer
UniProt: P33981
Entrez ID: 7272
|
Does Knockout of CDK7 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
CDK7
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CDK7 (cyclin dependent kinase 7)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, RNA polymerase II promoter clearance, RNA polymerase II transcription initiation surveillance, cell division, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization, regulation of G1/S transition of mitotic cell cycle, regulation of cell cycle, snRNA transcription by RNA polymerase II, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter, transcription pausing by RNA polymerase II; MF: ATP binding, ATP-dependent activity, acting on DNA, RNA polymerase II CTD heptapeptide repeat S5 kinase activity, RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: CAK-ERCC2 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, fibrillar center, male germ cell nucleus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, transcription factor TFIIH core complex, transcription factor TFIIH holo complex, transcription factor TFIIK complex
Pathways: AndrogenReceptor, BCR, Basal transcription factors - Homo sapiens (human), Cardiac Hypertrophic Response, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cyclin A/B1/B2 associated events during G2/M transition, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA Repair, DNA Repair Pathways Full Network, Disease, Dual incision in TC-NER, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, G1 Phase, G1 to S cell cycle control, G1/S Transition, G2/M Transition, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Integrated breast cancer pathway, Late Phase of HIV Life Cycle, Metabolism of RNA, MicroRNAs in cardiomyocyte hypertrophy, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Retinoic acid receptors-mediated signaling, S Phase, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by RUNX1, Viral Infection Pathways, cyclins and cell cycle regulation, estrogen responsive protein efp controls cell cycle and breast tumors growth, mRNA Capping, sonic hedgehog receptor ptc1 regulates cell cycle
UniProt: P50613
Entrez ID: 1022
|
Does Knockout of ATP2C2 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
ATP2C2
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: ATP2C2 (ATPase secretory pathway Ca2+ transporting 2)
Type: protein-coding
Summary: Enables P-type calcium transporter activity and P-type manganese transporter activity. Predicted to be involved in calcium ion transmembrane transport; cellular calcium ion homeostasis; and manganese ion transport. Predicted to act upstream of or within mammary gland epithelium development; positive regulation of calcium ion import; and protein localization to plasma membrane. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum; and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, intracellular calcium ion homeostasis, mammary gland epithelium development, manganese ion transmembrane transport, manganese ion transport, monoatomic ion transport, positive regulation of calcium ion import, protein localization to plasma membrane; MF: ATP binding, ATP hydrolysis activity, P-type calcium transporter activity, P-type manganese transporter activity, metal ion binding, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi membrane, basolateral plasma membrane, cytoplasmic side of plasma membrane, cytoplasmic vesicle, endoplasmic reticulum, membrane, perinuclear region of cytoplasm, plasma membrane, trans-Golgi network membrane
Pathways: Ion channel transport, Ion transport by P-type ATPases, Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4), Transport of small molecules, Vitamin D Receptor Pathway
UniProt: O75185
Entrez ID: 9914
|
Does Knockout of CCT3 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
CCT3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CCT3 (chaperonin containing TCP1 subunit 3)
Type: protein-coding
Summary: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants have been characterized for this gene. In addition, a pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of protein localization to Cajal body, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, RNA binding, hydrolase activity, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, chaperonin-containing T-complex, cytoplasm, cytoskeleton, cytosol, extracellular exosome, microtubule, zona pellucida receptor complex
Pathways: 16p11.2 proximal deletion syndrome, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Chaperonin-mediated protein folding, Cilium Assembly, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Folding of actin by CCT/TriC, Formation of tubulin folding intermediates by CCT/TriC, Metabolism of proteins, Organelle biogenesis and maintenance, Prefoldin mediated transfer of substrate to CCT/TriC, Protein folding
UniProt: P49368
Entrez ID: 7203
|
Does Knockout of HAUS4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
HAUS4
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: HAUS4 (HAUS augmin like complex subunit 4)
Type: protein-coding
Summary: This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: cell division, centrosome cycle, regulation of microtubule nucleation, spindle assembly; MF: microtubule minus-end binding, protein binding; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule, mitotic spindle microtubule, spindle
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9H6D7
Entrez ID: 54930
|
Does Knockout of URM1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
URM1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: URM1 (ubiquitin related modifier 1)
Type: protein-coding
Summary: Enables sulfur carrier activity. Involved in tRNA thio-modification and tRNA wobble uridine modification. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble uridine modification; MF: protein binding, protein tag activity, sulfur carrier activity; CC: cytoplasm, cytosol, nucleus
Pathways: Metabolism of RNA, Sulfur relay system - Homo sapiens (human), tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q9BTM9
Entrez ID: 81605
|
Does Knockout of NMUR1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
NMUR1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: NMUR1 (neuromedin U receptor 1)
Type: protein-coding
Summary: Enables neuromedin U binding activity and neuromedin U receptor activity. Involved in several processes, including activation of phospholipase C activity; chloride transport; and second-messenger-mediated signaling. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, calcium-mediated signaling, chloride transport, neuropeptide signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of calcium-mediated signaling, signal transduction, smooth muscle contraction; MF: G protein-coupled receptor activity, neuromedin U binding, neuromedin U receptor activity, neuropeptide receptor activity; CC: cilium, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q9HB89
Entrez ID: 10316
|
Does Knockout of CDC20 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
CDC20
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CDC20 (cell division cycle 20)
Type: protein-coding
Summary: CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G2/M transition of mitotic cell cycle, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, anaphase-promoting complex-dependent catabolic process, cell differentiation, cell division, metaphase/anaphase transition of cell cycle, metaphase/anaphase transition of meiosis I, mitotic sister chromatid cohesion, mitotic spindle assembly, mitotic spindle assembly checkpoint signaling, nervous system development, positive regulation of anaphase-promoting complex-dependent catabolic process, positive regulation of cell population proliferation, positive regulation of mitotic metaphase/anaphase transition, positive regulation of synapse maturation, positive regulation of synaptic plasticity, positive regulation of ubiquitin protein ligase activity, protein deubiquitination, protein ubiquitination, regulation of dendrite development, regulation of meiotic cell cycle, regulation of meiotic nuclear division, regulation of mitotic cell cycle; MF: anaphase-promoting complex binding, histone deacetylase binding, protein binding, ubiquitin ligase activator activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activator activity; CC: anaphase-promoting complex, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, mitotic checkpoint complex, nucleoplasm, perinuclear region of cytoplasm, protein-containing complex, spindle, spindle pole
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Antigen processing: Ubiquitination & Proteasome degradation, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Deubiquitination, EML4 and NUDC in mitotic spindle formation, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), PLK1 signaling events, Phosphorylation of Emi1, Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, Regulation of sister chromatid separation at the metaphase-anaphase transition, Resolution of Sister Chromatid Cohesion, SCF-beta-TrCP mediated degradation of Emi1, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human)
UniProt: Q12834
Entrez ID: 991
|
Does Knockout of RPS27A in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
RPS27A
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: RPS27A (ribosomal protein S27a)
Type: protein-coding
Summary: Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008].
Gene Ontology: BP: cytoplasmic translation, modification-dependent protein catabolic process, protein ubiquitination, ribosomal small subunit biogenesis, translation; MF: RNA binding, metal ion binding, protein binding, protein tag activity, structural constituent of ribosome, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endocytic vesicle membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome membrane, extracellular exosome, extracellular space, membrane, mitochondrial outer membrane, nucleolus, nucleoplasm, nucleus, plasma membrane, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse, vesicle
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activated NOTCH1 Transmits Signal to the Nucleus, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Activation of NF-kappaB in B cells, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Adaptive Immune System, Adherens junctions interactions, Aerobic respiration and respiratory electron transport, Aggrephagy, Alpha-protein kinase 1 signaling pathway, Amyloid fiber formation, Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Antiviral mechanism by IFN-stimulated genes, Apoptosis, Asparagine N-linked glycosylation, Assembly Of The HIV Virion, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Autophagy, Axon guidance, Bacterial Infection Pathways, Beta-catenin independent WNT signaling, Budding and maturation of HIV virion, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Calnexin/calreticulin cycle, Cap-dependent Translation Initiation, Cargo recognition for clathrin-mediated endocytosis, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell death signalling via NRAGE, NRIF and NADE, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular response to chemical stress, Cellular response to hypoxia, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Chaperone Mediated Autophagy, Circadian clock, Class I MHC mediated antigen processing & presentation, Clathrin-mediated endocytosis, Co-inhibition by PD-1, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Coronavirus disease - COVID-19 - Homo sapiens (human), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, Cytoplasmic Ribosomal Proteins, Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, Deactivation of the beta-catenin transactivating complex, Death Receptor Signaling, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of carbohydrate metabolism, Diseases of metabolism, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downregulation of ERBB2 signaling, Downregulation of ERBB2:ERBB3 signaling, Downregulation of ERBB4 signaling, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Downregulation of TGF-beta receptor signaling, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, EGFR downregulation, ER Quality Control Compartment (ERQC), ER-Phagosome pathway, Endosomal Sorting Complex Required For Transport (ESCRT), Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Evasion by RSV of host interferon responses, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, FLT3 Signaling, FLT3 signaling by CBL mutants, FLT3 signaling in disease, Fanconi Anemia Pathway, Fc epsilon receptor (FCERI) signaling, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, G1 Phase, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), GTP hydrolysis and joining of the 60S ribosomal subunit, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Glycogen metabolism, Glycogen storage diseases, Glycogen synthesis, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HIV Infection, HIV Life Cycle, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Homology Directed Repair, Host Interactions of HIV factors, IKK complex recruitment mediated by RIP1, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, IRAK2 mediated activation of TAK1 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, ISG15 antiviral mechanism, Immune System, Inactivation of CSF3 (G-CSF) signaling, Infection with Mycobacterium tuberculosis, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, InlA-mediated entry of Listeria monocytogenes into host cells, InlB-mediated entry of Listeria monocytogenes into host cell, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, Ion channel transport, Iron uptake and transport, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Josephin domain DUBs, KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), L13a-mediated translational silencing of Ceruloplasmin expression, Late Phase of HIV Life Cycle, Late SARS-CoV-2 Infection Events, Late endosomal microautophagy, Listeria monocytogenes entry into host cells, M Phase, MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Macroautophagy, Major pathway of rRNA processing in the nucleolus and cytosol, Maturation of protein E, Membrane Trafficking, Membrane binding and targetting of GAG proteins, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, Metalloprotease DUBs, Mitophagy, Mitophagy - animal - Homo sapiens (human), Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Modulation by Mtb of host immune system, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Myoclonic epilepsy of Lafora, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, NF-kB is activated and signals survival, NIK-->noncanonical NF-kB signaling, NOD1/2 Signaling Pathway, NOTCH1 Intracellular Domain Regulates Transcription, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Neddylation, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of FLT3, Negative regulation of MAPK pathway, Negative regulation of MET activity, Negative regulation of NOTCH4 signaling, Negative regulators of DDX58/IFIH1 signaling, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear events mediated by NFE2L2, Nucleotide Excision Repair, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oncogene Induced Senescence, Orc1 removal from chromatin, Ovarian tumor domain proteases, Oxidative Stress Induced Senescence, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PD-L1(CD274) glycosylation and translocation to plasma membrane, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, PINK1-PRKN Mediated Mitophagy, PIP3 activates AKT signaling, PTEN Regulation, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Peptide chain elongation, Peroxisomal protein import, Pexophagy, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Post-translational protein modification, Prevention of phagosomal-lysosomal fusion, Processing of DNA double-strand break ends, Programmed Cell Death, Protein localization, Protein ubiquitination, Pyruvate metabolism, RAF/MAP kinase cascade, RAS processing, RIPK1-mediated regulated necrosis, RNA Polymerase II Transcription, RSV-host interactions, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Recognition of DNA damage by PCNA-containing replication complex, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulated Necrosis, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of BACH1 activity, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of FZD by ubiquitination, Regulation of Homotypic Cell-Cell Adhesion, Regulation of NF-kappa B signaling, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PLK1 Activity at G2/M Transition, Regulation of PTEN localization, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation, Regulation of TNFR1 signaling, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of innate immune responses to cytosolic DNA, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of necroptotic cell death, Regulation of pyruvate metabolism, Regulation of signaling by CBL, Respiratory Syncytial Virus Infection Pathway, Response of EIF2AK4 (GCN2) to amino acid deficiency, Response of Mtb to phagocytosis, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 activates/modulates innate immune responses, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, SPOP-mediated proteasomal degradation of PD-L1(CD274), SRP-dependent cotranslational protein targeting to membrane, Selective autophagy, Selenoamino acid metabolism, Selenocysteine synthesis, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by CSF1 (M-CSF) in myeloid cells, Signaling by CSF3 (G-CSF), Signaling by EGFR, Signaling by EGFR in Cancer, Signaling by ERBB2, Signaling by ERBB4, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Hedgehog, Signaling by Interleukins, Signaling by Ligand-Responsive EGFR Variants in Cancer, Signaling by MET, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD Domain Mutants in Cancer, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by NOTCH4, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spry regulation of FGF signaling, Stabilization of p53, Stimuli-sensing channels, Suppression of phagosomal maturation, Switching of origins to a post-replicative state, Synthesis And Processing Of GAG, GAGPOL Polyproteins, Synthesis of DNA, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, TAK1-dependent IKK and NF-kappa-B activation , TCF dependent signaling in response to WNT, TCR signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), TICAM1, RIP1-mediated IKK complex recruitment, TICAM1,TRAF6-dependent induction of TAK1 complex, TICAM1-dependent activation of IRF3/IRF7, TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR2 non-canonical NF-kB pathway, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , Termination of translesion DNA synthesis, The role of GTSE1 in G2/M progression after G2 checkpoint, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Translation initiation complex formation, Translation of Structural Proteins, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Homo sapiens (human), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, VLDLR internalisation and degradation, Vesicle-mediated transport, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Viral mRNA Translation, Vpu mediated degradation of CD4, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, activated TAK1 mediates p38 MAPK activation, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, p75 NTR receptor-mediated signalling, p75NTR recruits signalling complexes, p75NTR signals via NF-kB, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62979
Entrez ID: 6233
|
Does Knockout of PRICKLE2 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
PRICKLE2
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: PRICKLE2 (prickle planar cell polarity protein 2)
Type: protein-coding
Summary: This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: Wnt signaling pathway, planar cell polarity pathway, blastocyst formation, protein localization to axon; MF: metal ion binding, zinc ion binding; CC: axon, axon initial segment, cytoplasm, dendrite, membrane, nuclear membrane, nucleus, postsynaptic density
Pathways: Wnt signaling, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q7Z3G6
Entrez ID: 166336
|
Does Knockout of RPS23 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
RPS23
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RPS23 (ribosomal protein S23)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant amino acid similarity with S. cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maintenance of translational fidelity, ribosomal small subunit biogenesis, stress granule assembly, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Post-translational protein modification, Protein hydroxylation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62266
Entrez ID: 6228
|
Does Knockout of ISY1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
ISY1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ISY1 (ISY1 spliceosome associated protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type catalytic step 1 spliceosome and catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, generation of catalytic spliceosome for second transesterification step, mRNA 3'-splice site recognition, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: Prp19 complex, U2-type catalytic step 1 spliceosome, catalytic step 2 spliceosome, nucleoplasm, nucleus, post-mRNA release spliceosomal complex, post-spliceosomal complex, spliceosomal complex
Pathways: Spliceosome - Homo sapiens (human)
UniProt: Q9ULR0
Entrez ID: 57461
|
Does Knockout of TBC1D25 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
TBC1D25
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: TBC1D25 (TBC1 domain family member 25)
Type: protein-coding
Summary: This gene encodes a protein with a TBC domain and functions as a Rab GTPase activating protein. The encoded protein is involved in the fusion of autophagosomes with endosomes and lysosomes. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: autophagy, regulation of autophagosome maturation; MF: GTPase activator activity, protein binding; CC: autophagosome, cytoplasm, cytoplasmic vesicle
Pathways: Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q3MII6
Entrez ID: 4943
|
Does Knockout of ANO1 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
ANO1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: ANO1 (anoctamin 1)
Type: protein-coding
Summary: Enables calcium activated cation channel activity; intracellular calcium activated chloride channel activity; and iodide transmembrane transporter activity. Involved in cation transport; inorganic anion transport; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in apical plasma membrane and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to heat, cellular response to peptide, chloride transmembrane transport, chloride transport, detection of temperature stimulus involved in sensory perception of pain, glial cell projection elongation, iodide transport, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, mucus secretion, phospholipase C-activating G protein-coupled receptor signaling pathway, protein localization to membrane; MF: calcium-activated cation channel activity, chloride channel activity, identical protein binding, intracellularly calcium-gated chloride channel activity, iodide transmembrane transporter activity, metal ion binding, protein binding, protein dimerization activity, protein homodimerization activity, signaling receptor binding, voltage-gated chloride channel activity; CC: apical plasma membrane, cell projection, chloride channel complex, extracellular exosome, membrane, nucleoplasm, plasma membrane, presynapse, synapse
Pathways: Disease, Induction of Cell-Cell Fusion, Infectious disease, Ion channel transport, Late SARS-CoV-2 Infection Events, SARS-CoV Infections, SARS-CoV-2 Infection, Stimuli-sensing channels, Transport of small molecules, Viral Infection Pathways
UniProt: Q5XXA6
Entrez ID: 55107
|
Does Knockout of TYMS in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
TYMS
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TYMS (thymidylate synthetase)
Type: protein-coding
Summary: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: DNA biosynthetic process, dTMP biosynthetic process, dTTP biosynthetic process, methylation, negative regulation of translation, nucleotide biosynthetic process, tetrahydrofolate interconversion, tetrahydrofolate metabolic process; MF: folic acid binding, mRNA regulatory element binding translation repressor activity, methyltransferase activity, sequence-specific mRNA binding, thymidylate synthase activity, transferase activity, transferase activity, transferring one-carbon groups; CC: cytoplasm, cytosol, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, nucleus
Pathways: Beta Ureidopropionase Deficiency, Capecitabine Action Pathway, Capecitabine Metabolism Pathway, Cell Cycle, Cell Cycle, Mitotic, Dihydropyrimidinase Deficiency, E2F transcription factor network, Ethanol effects on histone modifications, Fluoropyrimidine Activity, Fluorouracil Action Pathway, Fluorouracil Metabolism Pathway, G1/S Transition, G1/S-Specific Transcription, Gemcitabine Action Pathway, Gemcitabine Metabolism Pathway, Interconversion of nucleotide di- and triphosphates, MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy), Metabolism, Metabolism of nucleotides, Mitotic G1 phase and G1/S transition, One carbon pool by folate - Homo sapiens (human), One-carbon metabolism, One-carbon metabolism and related pathways, Pyrimidine Metabolism, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), Retinoblastoma gene in cancer, Trans-sulfuration and one-carbon metabolism, UMP Synthase Deiciency (Orotic Aciduria), dTMP <i>de novo</i> biosynthesis (mitochondrial), pyrimidine deoxyribonucleosides salvage, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides biosynthesis from CTP, superpathway of pyrimidine deoxyribonucleoside salvage, superpathway of pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis
UniProt: P04818
Entrez ID: 7298
|
Does Knockout of RFT1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
RFT1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RFT1 (RFT1 glycolipid translocator homolog)
Type: protein-coding
Summary: This gene encodes an enzyme which catalyzes the translocation of the Man(5)GlcNAc (2)-PP-Dol intermediate from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane in the pathway for the N-glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type In.[provided by RefSeq, Dec 2008].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, glycolipid translocation, protein N-linked glycosylation; MF: glycolipid floppase activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective RFT1 causes CDG-1n, Disease, Diseases associated with N-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, Post-translational protein modification
UniProt: Q96AA3
Entrez ID: 91869
|
Does Knockout of RARS2 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
RARS2
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: RARS2 (arginyl-tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: arginyl-tRNA aminoacylation, gene expression, mitochondrial translation, tRNA aminoacylation for protein translation, tRNA metabolic process, translation; MF: ATP binding, RNA binding, aminoacyl-tRNA ligase activity, arginine-tRNA ligase activity, ligase activity, nucleotide binding, protein binding; CC: cytoplasm, membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Arginine and Proline Metabolism, Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency), Creatine deficiency, guanidinoacetate methyltransferase deficiency, Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency), Hyperornithinemia with gyrate atrophy (HOGA), Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome], Hyperprolinemia Type I, Hyperprolinemia Type II, L-arginine:glycine amidinotransferase deficiency, Metabolism of proteins, Mitochondrial tRNA aminoacylation, Ornithine Aminotransferase Deficiency (OAT Deficiency), Prolidase Deficiency (PD), Prolinemia Type II, Translation, tRNA Aminoacylation, tRNA charging
UniProt: Q5T160
Entrez ID: 57038
|
Does Knockout of IL15 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
IL15
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: IL15 (interleukin 15)
Type: protein-coding
Summary: The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: NK T cell proliferation, cell maturation, cell-cell signaling, extrathymic T cell selection, immune response, interleukin-15-mediated signaling pathway, lymph node development, macrophage differentiation, natural killer cell differentiation, natural killer cell proliferation, negative regulation of cold-induced thermogenesis, neutrophil activation, positive regulation of T cell proliferation, positive regulation of cell population proliferation, positive regulation of cytokine production, positive regulation of immune response, positive regulation of inflammatory response, positive regulation of interleukin-17 production, positive regulation of natural killer cell differentiation, positive regulation of natural killer cell proliferation, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of phagocytosis, positive regulation of tissue remodeling, regulation of T cell differentiation, regulation of defense response to virus by host, signal transduction, tyrosine phosphorylation of STAT protein; MF: cytokine activity, cytokine receptor binding, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, endosome, extracellular region, extracellular space, nuclear speck, nucleoplasm, nucleus
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Cytokines and Inflammatory Response, Development and heterogeneity of the ILC family, Human T-cell leukemia virus 1 infection - Homo sapiens (human), IL2, Immune System, Interleukin-15 signaling, Interleukin-2 family signaling, Intestinal immune network for IgA production - Homo sapiens (human), JAK-STAT signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Rheumatoid arthritis - Homo sapiens (human), Signaling by Interleukins, TNF signaling pathway - Homo sapiens (human)
UniProt: P40933
Entrez ID: 3600
|
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