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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of PYCR2 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
PYCR2
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: PYCR2 (pyrroline-5-carboxylate reductase 2)
Type: protein-coding
Summary: This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: L-proline biosynthetic process, amino acid biosynthetic process, cellular response to oxidative stress; MF: oxidoreductase activity, protein binding, pyrroline-5-carboxylate reductase activity; CC: cytoplasm, cytosol, mitochondrial matrix, mitochondrion
Pathways: Arginine and Proline Metabolism, Arginine and proline metabolism - Homo sapiens (human), Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency), Creatine deficiency, guanidinoacetate methyltransferase deficiency, Glutamate and glutamine metabolism, Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency), Hyperornithinemia with gyrate atrophy (HOGA), Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome], Hyperprolinemia Type I, Hyperprolinemia Type II, L-arginine:glycine amidinotransferase deficiency, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of amino acids and derivatives, Ornithine Aminotransferase Deficiency (OAT Deficiency), Prolidase Deficiency (PD), Prolinemia Type II, proline biosynthesis
UniProt: Q96C36
Entrez ID: 29920
|
Does Knockout of C12orf56 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
C12orf56
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: C12orf56 (chromosome 12 open reading frame 56)
Type: protein-coding
Summary: chromosome 12 open reading frame 56
Gene Ontology:
Pathways:
UniProt: Q8IXR9
Entrez ID: 115749
|
Does Knockout of TOM1L2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
TOM1L2
|
cell proliferation
|
Cancer Cell Line
|
Gene: TOM1L2 (target of myb1 like 2 membrane trafficking protein)
Type: protein-coding
Summary: This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017].
Gene Ontology: BP: negative regulation of mitotic nuclear division, protein transport, signal transduction; MF: clathrin binding, phosphatidylinositol binding, protein binding, protein kinase binding, ubiquitin binding; CC: endosome, extracellular exosome, membrane
Pathways: EGFR1, Fibroblast growth factor-1
UniProt: Q6ZVM7
Entrez ID: 146691
|
Does Knockout of PHACTR4 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
PHACTR4
|
response to virus
|
Hepatoma Cell Line
|
Gene: PHACTR4 (phosphatase and actin regulator 4)
Type: protein-coding
Summary: This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has been shown to interact with actin and PP1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Rho protein signal transduction, actin cytoskeleton organization, closure of optic fissure, enteric nervous system development, negative regulation of integrin-mediated signaling pathway, nervous system development, neural crest cell migration, neural tube closure, positive regulation of catalytic activity, regulation of cell cycle; MF: actin binding, protein phosphatase 1 binding, protein phosphatase activator activity; CC: cell projection, cytoplasm, lamellipodium
Pathways:
UniProt: Q8IZ21
Entrez ID: 65979
|
Does Knockout of GRWD1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
GRWD1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: GRWD1 (glutamate rich WD repeat containing 1)
Type: protein-coding
Summary: This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: DNA replication, nucleosome assembly, nucleosome disassembly, ribosome biogenesis; MF: DNA replication origin binding, RNA binding, chromatin binding, histone binding, protein binding; CC: chromosome, cytosol, nucleolus, nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: Q9BQ67
Entrez ID: 83743
|
Does Knockout of SRD5A1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
SRD5A1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SRD5A1 (steroid 5 alpha-reductase 1)
Type: protein-coding
Summary: Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: androgen biosynthetic process, androgen catabolic process, androgen metabolic process, bone development, cell differentiation, cellular response to cAMP, cellular response to dexamethasone stimulus, cellular response to epinephrine stimulus, cellular response to estradiol stimulus, cellular response to growth factor stimulus, cellular response to insulin stimulus, cellular response to serotonin, cellular response to starvation, cellular response to testosterone stimulus, cerebral cortex development, diterpenoid metabolic process, female genitalia development, hippocampus development, hypothalamus development, lipid metabolic process, liver development, male genitalia development, male gonad development, pituitary gland development, progesterone metabolic process, response to estradiol, response to estrogen, response to follicle-stimulating hormone, response to fungicide, response to growth hormone, response to muscle activity, response to testosterone, response to xenobiotic stimulus, serotonin metabolic process, sex determination, sex differentiation, spinal cord development, steroid biosynthetic process, steroid metabolic process, thalamus development, urogenital system development; MF: 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity, 3-oxo-5-alpha-steroid 4-dehydrogenase activity, NADPH binding, amide binding, electron transfer activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, protein binding; CC: cell body fiber, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, neuronal cell body, perinuclear region of cytoplasm
Pathways: 17-Beta Hydroxysteroid Dehydrogenase III Deficiency, Androgen and Estrogen Metabolism, Androgen biosynthesis, Aromatase deficiency, Mammalian disorder of sexual development, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, Steroid hormone biosynthesis - Homo sapiens (human), allopregnanolone biosynthesis, androgen biosynthesis, superpathway of steroid hormone biosynthesis
UniProt: P18405
Entrez ID: 6715
|
Does Knockout of QPRT in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
QPRT
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: QPRT (quinolinate phosphoribosyltransferase)
Type: protein-coding
Summary: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: 'de novo' NAD+ biosynthetic process from L-tryptophan, NAD+ biosynthetic process, NAD+ metabolic process, pyridine nucleotide biosynthetic process, quinolinate catabolic process, quinolinate metabolic process; MF: glycosyltransferase activity, identical protein binding, nicotinate-nucleotide diphosphorylase (carboxylating) activity, pentosyltransferase activity, protein binding, transferase activity; CC: catalytic complex, cytoplasm, cytosol, extracellular exosome
Pathways: 16p11.2 proximal deletion syndrome, Kynurenine Pathway and links to Cellular Senescence, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, NAD <i>de novo</i> biosynthesis, NAD Biosynthesis II (from tryptophan), NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde, NAD+ biosynthetic pathways, Nicotinate and Nicotinamide Metabolism, Nicotinate and nicotinamide metabolism - Homo sapiens (human), Nicotinate metabolism, superpathway of tryptophan utilization
UniProt: Q15274
Entrez ID: 23475
|
Does Knockout of CENPL in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
CENPL
|
cell proliferation
|
Cancer Cell Line
|
Gene: CENPL (centromere protein L)
Type: protein-coding
Summary: CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008].
Gene Ontology: CC: chromosome, chromosome, centromeric region, cytosol, inner kinetochore, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8N0S6
Entrez ID: 91687
|
Does Knockout of MRPL41 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
MRPL41
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MRPL41 (mitochondrial ribosomal protein L41)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q8IXM3
Entrez ID: 64975
|
Does Knockout of RSL24D1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
RSL24D1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: RSL24D1 (ribosomal L24 domain containing 1)
Type: protein-coding
Summary: This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24. Although this gene has been referred to as RPL24, L30, and 60S ribosomal protein L30 isolog in the sequence databases, it is distinct from the human genes officially named RPL24 (which itself has been referred to as ribosomal protein L30) and RPL30. The protein encoded by this gene localizes to the nucleolus and is thought to play a role in the biogenesis of the 60S ribosomal subunit. The precise function of this gene is currently unknown. This gene utilizes alternative polyadenylation signals and has multiple pseudogenes. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome biogenesis; MF: protein binding, structural constituent of ribosome; CC: nucleolus, nucleoplasm, nucleus
Pathways: Coronavirus disease - COVID-19 - Homo sapiens (human), Ribosome - Homo sapiens (human)
UniProt: Q9UHA3
Entrez ID: 51187
|
Does Knockout of XRN2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
XRN2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: XRN2 (5'-3' exoribonuclease 2)
Type: protein-coding
Summary: This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: DNA-templated transcription termination, RNA catabolic process, RNA metabolic process, RNA processing, hippocampus development, mRNA processing, neuron differentiation, nuclear-transcribed mRNA catabolic process, nucleobase-containing compound metabolic process, rRNA processing, retina development in camera-type eye, spermatogenesis, termination of RNA polymerase II transcription; MF: 3'-5'-RNA exonuclease activity, 5'-3' RNA exonuclease activity, 5'-3' exonuclease activity, DNA binding, RNA binding, exonuclease activity, hydrolase activity, identical protein binding, metal ion binding, nuclease activity, nucleic acid binding, protein binding, transcription termination site sequence-specific DNA binding, zinc ion binding; CC: aggresome, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nuclear RNA decay, Protein folding, RNA degradation - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), mRNA Processing, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9H0D6
Entrez ID: 22803
|
Does Activation of PXDN in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
PXDN
|
protein/peptide accumulation
|
T cell
|
Gene: PXDN (peroxidasin)
Type: protein-coding
Summary: This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: angiogenesis, basement membrane assembly, basement membrane organization, cell adhesion, cellular oxidant detoxification, collagen fibril organization, extracellular matrix organization, eye development, hydrogen peroxide catabolic process, immune response, negative regulation of cytokine-mediated signaling pathway, protein homooligomerization, protein homotrimerization, response to oxidative stress, system development; MF: extracellular matrix structural constituent, heme binding, interleukin-1 receptor antagonist activity, lactoperoxidase activity, laminin-1 binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on peroxide as acceptor, peroxidase activity; CC: basement membrane, cell surface, endoplasmic reticulum, extracellular exosome, extracellular matrix, extracellular region, extracellular space
Pathways: Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, Developmental Biology, EGF-EGFR signaling pathway, Extracellular matrix organization, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
UniProt: Q92626
Entrez ID: 7837
|
Does Knockout of RAET1L in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
RAET1L
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RAET1L (retinoic acid early transcript 1L)
Type: protein-coding
Summary: RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, immune response, immune system process, positive regulation of T cell mediated cytotoxicity; CC: endoplasmic reticulum, external side of plasma membrane, extracellular region, extracellular space, membrane, plasma membrane, side of membrane
Pathways: Metabolism of proteins, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q5VY80
Entrez ID: 154064
|
Does Activation of POSTN in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
POSTN
|
protein/peptide accumulation
|
T cell
|
Gene: POSTN (periostin)
Type: protein-coding
Summary: This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: bone regeneration, cell adhesion, cellular response to fibroblast growth factor stimulus, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, cellular response to vitamin K, extracellular matrix organization, negative regulation of cell-matrix adhesion, negative regulation of substrate adhesion-dependent cell spreading, neuron projection extension, positive regulation of chemokine (C-X-C motif) ligand 2 production, positive regulation of smooth muscle cell migration, regulation of Notch signaling pathway, regulation of systemic arterial blood pressure, response to estradiol, response to hypoxia, response to mechanical stimulus, response to muscle activity, tissue development; MF: cell adhesion molecule binding, extracellular matrix structural constituent, heparin binding, metal ion binding, protein binding; CC: Golgi apparatus, extracellular matrix, extracellular region, extracellular space, neuromuscular junction, trans-Golgi network
Pathways: Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, Hypothesized Pathways in Pathogenesis of Cardiovascular Disease
UniProt: Q15063
Entrez ID: 10631
|
Does Activation of PTGER4 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
PTGER4
|
protein/peptide accumulation
|
T cell
|
Gene: PTGER4 (prostaglandin E receptor 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ERK1 and ERK2 cascade, G protein-coupled receptor signaling pathway, JNK cascade, MAPK cascade, T-helper cell differentiation, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, bone development, cellular response to mechanical stimulus, cellular response to prostaglandin E stimulus, immune response, inflammatory response, negative regulation of cytokine production, negative regulation of eosinophil extravasation, negative regulation of inflammatory response, negative regulation of integrin activation, positive regulation of cytokine production, positive regulation of cytosolic calcium ion concentration, positive regulation of inflammatory response, regulation of stress fiber assembly, response to lipid, response to mechanical stimulus, response to prostaglandin E, signal transduction; MF: G protein-coupled receptor activity, prostaglandin E receptor activity, prostaglandin receptor activity, protein binding; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), Eicosanoid ligand-binding receptors, G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Genotoxicity pathway, Human cytomegalovirus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Prostaglandin Synthesis and Regulation, Prostanoid ligand receptors, Relationship between inflammation, COX-2 and EGFR, Renin secretion - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Small Ligand GPCRs, Vitamin D Receptor Pathway, eicosanoid metabolism
UniProt: P35408
Entrez ID: 5734
|
Does Knockout of LIN28B in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
LIN28B
|
response to chemicals
|
Melanoma Cell Line
|
Gene: LIN28B (lin-28 RNA binding posttranscriptional regulator B)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: RNA 3'-end processing, RNA destabilization, miRNA catabolic process, negative regulation of pre-miRNA processing, negative regulation of primary miRNA processing, positive regulation of miRNA catabolic process, post-transcriptional regulation of gene expression, pre-miRNA processing, regulatory ncRNA-mediated gene silencing; MF: RNA binding, mRNA binding, metal ion binding, nucleic acid binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Cardiac Progenitor Differentiation, Hippo-Merlin Signaling Dysregulation, Validated targets of C-MYC transcriptional activation
UniProt: Q6ZN17
Entrez ID: 389421
|
Does Knockout of ZNF33A in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
ZNF33A
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: ZNF33A (zinc finger protein 33A)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: Q06730
Entrez ID: 7581
|
Does Knockout of MRPS7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
MRPS7
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: MRPS7 (mitochondrial ribosomal protein S7)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, mRNA binding, rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9Y2R9
Entrez ID: 51081
|
Does Knockout of FAHD2A in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
FAHD2A
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: FAHD2A (fumarylacetoacetate hydrolase domain containing 2A)
Type: protein-coding
Summary: Predicted to enable hydro-lyase activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: oxaloacetate metabolic process; MF: catalytic activity, isomerase activity, metal ion binding, oxaloacetate tautomerase activity, protein binding; CC: mitochondrion
Pathways:
UniProt: Q96GK7
Entrez ID: 51011
|
Does Knockout of MCEE in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
MCEE
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: MCEE (methylmalonyl-CoA epimerase)
Type: protein-coding
Summary: The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: L-methylmalonyl-CoA metabolic process, short-chain fatty acid catabolic process; MF: isomerase activity, metal ion binding, methylmalonyl-CoA epimerase activity, protein binding; CC: mitochondrial matrix, mitochondrion
Pathways: 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency, 2-oxobutanoate degradation, 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency, 3-Methylcrotonyl Coa Carboxylase Deficiency Type I, 3-Methylglutaconic Aciduria Type I, 3-Methylglutaconic Aciduria Type III, 3-Methylglutaconic Aciduria Type IV, 3-hydroxyisobutyric acid dehydrogenase deficiency, 3-hydroxyisobutyric aciduria, Beta-Ketothiolase Deficiency, Fatty acid metabolism, Glyoxylate and dicarboxylate metabolism - Homo sapiens (human), Isobutyryl-coa dehydrogenase deficiency, Isovaleric Aciduria, Isovaleric acidemia, Malonic Aciduria, Malonyl-coa decarboxylase deficiency, Maple Syrup Urine Disease, Metabolism, Metabolism of lipids, Methylmalonate Semialdehyde Dehydrogenase Deficiency, Methylmalonic Aciduria, Methylmalonic Aciduria Due to Cobalamin-Related Disorders, Mitochondrial Fatty Acid Beta-Oxidation, Propanoate Metabolism, Propanoate metabolism - Homo sapiens (human), Propionic Acidemia, Propionyl-CoA catabolism, Threonine and 2-Oxobutanoate Degradation, Valine, Leucine and Isoleucine Degradation, Valine, leucine and isoleucine degradation - Homo sapiens (human), Vitamin B12 metabolism, propionyl-CoA degradation, superpathway of methionine degradation
UniProt: Q96PE7
Entrez ID: 84693
|
Does Knockout of FOXA1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
FOXA1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: FOXA1 (forkhead box A1)
Type: protein-coding
Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Notch signaling pathway, alveolar secondary septum development, anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, cell differentiation, chromatin organization, chromatin remodeling, connective tissue development, dopaminergic neuron differentiation, dorsal/ventral neural tube patterning, epithelial cell maturation involved in prostate gland development, epithelial tube branching involved in lung morphogenesis, glucose homeostasis, hormone metabolic process, lung development, lung epithelial cell differentiation, lung morphogenesis, mesenchymal-epithelial cell signaling involved in prostate gland development, negative regulation of epithelial to mesenchymal transition, negative regulation of transcription by RNA polymerase II, neuron differentiation, neuron fate specification, positive regulation of DNA-binding transcription factor activity, positive regulation of apoptotic process, positive regulation of cell-cell adhesion mediated by cadherin, positive regulation of dopaminergic neuron differentiation, positive regulation of intracellular estrogen receptor signaling pathway, positive regulation of miRNA transcription, positive regulation of mitotic cell cycle, positive regulation of smoothened signaling pathway, positive regulation of transcription by RNA polymerase II, prostate gland epithelium morphogenesis, prostate gland stromal morphogenesis, regulation of DNA-templated transcription, regulation of cell cycle, regulation of gene expression, regulation of transcription by RNA polymerase II, respiratory basal cell differentiation, response to estradiol, secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development, smoothened signaling pathway, tube morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, protein binding, protein domain specific binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, fibrillar center, microvillus, nucleoplasm, nucleus
Pathways: AndrogenReceptor, Developmental Biology, Direct p53 effectors, ESR-mediated signaling, Endoderm differentiation, Estrogen-dependent gene expression, FOXA1 transcription factor network, FOXA2 and FOXA3 transcription factor networks, FOXA2 pathway, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Formation of axial mesoderm, Gastrulation, Mesodermal commitment pathway, Signal Transduction, Signaling by Nuclear Receptors
UniProt: P55317
Entrez ID: 3169
|
Does Knockout of ANKRD11 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
ANKRD11
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: ANKRD11 (ankyrin repeat domain containing 11)
Type: protein-coding
Summary: This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: face development, face morphogenesis, head morphogenesis, odontogenesis of dentin-containing tooth, skeletal system morphogenesis; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q6UB99
Entrez ID: 29123
|
Does Knockout of LRRC19 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
LRRC19
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: LRRC19 (leucine rich repeat containing 19)
Type: protein-coding
Summary: Predicted to enable signaling receptor activity. Acts upstream of or within positive regulation of NIK/NF-kappaB signaling. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: host-mediated modulation of intestinal microbiota composition, positive regulation of canonical NF-kappaB signal transduction, positive regulation of non-canonical NF-kappaB signal transduction, regulation of cytokine production, regulation of inflammatory response, toll-like receptor signaling pathway; MF: protein binding, signaling receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q9H756
Entrez ID: 64922
|
Does Knockout of SPOUT1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
SPOUT1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SPOUT1 (SPOUT domain containing methyltransferase 1)
Type: protein-coding
Summary: Enables miRNA binding activity. Involved in maintenance of centrosome location and production of miRNAs involved in gene silencing by miRNA. Located in kinetochore; mitotic spindle; and spindle pole centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, maintenance of centrosome location, methylation, miRNA processing, post-transcriptional regulation of gene expression, rRNA base methylation, rRNA processing; MF: RNA binding, S-adenosyl-L-methionine binding, methyltransferase activity, miRNA binding, protein binding, rRNA (uridine-N3-)-methyltransferase activity, transferase activity; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, kinetochore, mitotic spindle, spindle, spindle pole centrosome
Pathways:
UniProt: Q5T280
Entrez ID: 51490
|
Does Knockout of HEATR4 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
HEATR4
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: HEATR4 (HEAT repeat containing 4)
Type: protein-coding
Summary: Predicted to enable oxidoreductase activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q86WZ0
Entrez ID: 399671
|
Does Knockout of NME5 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
NME5
|
response to virus
|
Huh-7 Cell
|
Gene: NME5 (NME/NM23 family member 5)
Type: protein-coding
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and spermatid development. Predicted to act upstream of or within cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and ventricular system development. Predicted to be located in cilium. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CTP biosynthetic process, DNA catabolic process, GTP biosynthetic process, UTP biosynthetic process, cell differentiation, cilium assembly, cilium movement, epithelial cilium movement involved in extracellular fluid movement, establishment of localization in cell, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, nucleoside metabolic process, spermatid development, spermatid differentiation, spermatogenesis, ventricular system development; MF: 3'-5'-DNA exonuclease activity, hydrolase activity, nucleoside diphosphate kinase activity, protein binding; CC: 9+2 motile cilium, cell projection, cilium, cytoplasm, cytoskeleton, extracellular region, motile cilium, radial spoke, sperm flagellum
Pathways: CMP phosphorylation, UTP and CTP <i>de novo</i> biosynthesis, adenosine deoxyribonucleotides <i>de novo</i> biosynthesis, guanosine deoxyribonucleotides <i>de novo</i> biosynthesis, guanosine nucleotides <i>de novo</i> biosynthesis, guanosine ribonucleotides <i>de novo</i> biosynthesis, purine deoxyribonucleosides salvage, purine nucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotide phosphorylation, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides biosynthesis from CTP, superpathway of purine nucleotide salvage, superpathway of pyrimidine deoxyribonucleoside salvage, superpathway of pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, superpathway of pyrimidine ribonucleotides <i>de novo</i> biosynthesis
UniProt: P56597
Entrez ID: 8382
|
Does Knockout of GNA14 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
GNA14
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: GNA14 (G protein subunit alpha 14)
Type: protein-coding
Summary: This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, action potential, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, inflammatory response, phospholipase C-activating dopamine receptor signaling pathway, positive regulation of inflammatory response, signal transduction; MF: G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, GTP binding, GTPase activity, guanyl nucleotide binding, metal ion binding, nucleotide binding, protein binding; CC: cytoplasm, extracellular exosome, heterotrimeric G-protein complex, plasma membrane
Pathways: ADP signalling through P2Y purinoceptor 1, Acetylcholine regulates insulin secretion, Amoebiasis - Homo sapiens (human), Arf6 signaling events, Calcium signaling pathway - Homo sapiens (human), Chagas disease - Homo sapiens (human), Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Endothelins, Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Free fatty acids regulate insulin secretion, G Protein Signaling Pathways, G alpha (i) signalling events, G alpha (q) signalling events, G-protein activation, G-protein mediated events, GPCR downstream signalling, Hemostasis, IL8- and CXCR1-mediated signaling events, IL8- and CXCR2-mediated signaling events, Integration of energy metabolism, LPA receptor mediated events, Metabolism, Metabolism of proteins, Opioid Signalling, PAR1-mediated thrombin signaling events, PAR4-mediated thrombin signaling events, PKC-gamma calcium signaling pathway in ataxia, PLC beta mediated events, Plasma membrane estrogen receptor signaling, Platelet activation, signaling and aggregation, Protein folding, Regulation of insulin secretion, S1P2 pathway, S1P3 pathway, Signal Transduction, Signal amplification, Signaling by GPCR, Sphingosine 1-phosphate (S1P) pathway, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane A2 receptor signaling, Thromboxane signalling through TP receptor
UniProt: O95837
Entrez ID: 9630
|
Does Knockout of B3GALT4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
B3GALT4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: B3GALT4 (beta-1,3-galactosyltransferase 4)
Type: protein-coding
Summary: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate derivative biosynthetic process, ganglioside biosynthetic process, glycosphingolipid biosynthetic process, lipid metabolic process, oligosaccharide biosynthetic process, protein O-linked glycosylation, protein glycosylation; MF: N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity, ganglioside galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Blood group systems biosynthesis, Ganglio Sphingolipid Metabolism, Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human), Glycosphingolipid metabolism, Lewis blood group biosynthesis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of lipids, Sphingolipid metabolism
UniProt: O96024
Entrez ID: 8705
|
Does Knockout of PREB in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
PREB
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: PREB (prolactin regulatory element binding)
Type: protein-coding
Summary: This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: COPII vesicle coating, COPII-coated vesicle cargo loading, endoplasmic reticulum to Golgi vesicle-mediated transport, lipoprotein transport, protein transport, regulation of COPII vesicle coating, vesicle-mediated transport; MF: DNA binding, GTPase binding, guanyl-nucleotide exchange factor activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, IRE1alpha activates chaperones, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Transport to the Golgi and subsequent modification, Unfolded Protein Response (UPR), Vesicle-mediated transport, XBP1(S) activates chaperone genes
UniProt: Q9HCU5
Entrez ID: 10113
|
Does Knockout of MOGAT2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
MOGAT2
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: MOGAT2 (monoacylglycerol O-acyltransferase 2)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: diacylglycerol biosynthetic process, glycerol metabolic process, intestinal absorption, lipid metabolic process, monoacylglycerol biosynthetic process, triglyceride biosynthetic process; MF: 2-acylglycerol O-acyltransferase activity, O-acyltransferase activity, acetyltransferase activity, acyltransferase activity, diacylglycerol O-acyltransferase activity, transferase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, perinuclear endoplasmic reticulum membrane, perinuclear region of cytoplasm
Pathways: Fat digestion and absorption - Homo sapiens (human), Glycerolipid metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, Triacylglyceride synthesis, Triglyceride biosynthesis, Triglyceride metabolism
UniProt: Q3SYC2
Entrez ID: 80168
|
Does Knockout of MYH7B in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 1
| 1,480
|
Knockout
|
MYH7B
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: MYH7B (myosin heavy chain 7B)
Type: protein-coding
Summary: The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: regulation of CAMKK-AMPK signaling cascade, regulation of calcium-mediated signaling, regulation of cardiac muscle cell contraction, regulation of cytosolic calcium ion concentration; MF: ATP binding, actin binding, actin filament binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding, protein binding; CC: cardiac myofibril, cytoplasm, membrane, myofibril, myosin II complex, myosin complex, myosin filament
Pathways:
UniProt: A7E2Y1
Entrez ID: 57644
|
Does Knockout of HMGCS1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
HMGCS1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Type: protein-coding
Summary: Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: acetyl-CoA metabolic process, cholesterol biosynthetic process, cholesterol metabolic process, farnesyl diphosphate biosynthetic process, mevalonate pathway, isoprenoid biosynthetic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: acyltransferase activity, hydroxymethylglutaryl-CoA synthase activity, protein binding, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Activation of gene expression by SREBF (SREBP), Alendronate Action Pathway, Atorvastatin Action Pathway, Butanoate metabolism - Homo sapiens (human), CHILD Syndrome, Cerivastatin Action Pathway, Cholesterol Biosynthesis Pathway, Cholesterol biosynthesis, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Cholesteryl ester storage disease, Chondrodysplasia Punctata II, X Linked Dominant (CDPX2), Desmosterolosis, Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, FOXA2 and FOXA3 transcription factor networks, Fluvastatin Action Pathway, Hyper-IgD syndrome, Hypercholesterolemia, Ibandronate Action Pathway, Lovastatin Action Pathway, Lysosomal Acid Lipase Deficiency (Wolman Disease), Metabolism, Metabolism of lipids, Metabolism of steroids, Mevalonic aciduria, PPAR signaling pathway - Homo sapiens (human), PPARA activates gene expression, Pamidronate Action Pathway, Pravastatin Action Pathway, Regulation of cholesterol biosynthesis by SREBP (SREBF), Regulation of lipid metabolism by PPARalpha, Risedronate Action Pathway, Rosuvastatin Action Pathway, SREBF and miR33 in cholesterol and lipid homeostasis, Simvastatin Action Pathway, Smith-Lemli-Opitz Syndrome (SLOS), Steroid Biosynthesis, Sterol regulatory element-binding proteins (SREBP) signaling, Synthesis and degradation of ketone bodies - Homo sapiens (human), Terpenoid backbone biosynthesis - Homo sapiens (human), Valine, leucine and isoleucine degradation - Homo sapiens (human), Wolman disease, Zoledronate Action Pathway, ketogenesis, mevalonate pathway, srebp control of lipid synthesis, superpathway of cholesterol biosynthesis, superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
UniProt: Q01581
Entrez ID: 3157
|
Does Knockout of TICRR in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
TICRR
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TICRR (TOPBP1 interacting checkpoint and replication regulator)
Type: protein-coding
Summary: Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, regulation of DNA-templated DNA replication initiation, response to ionizing radiation; MF: chromatin binding, protein binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Transition, Mitotic G2-G2/M phases
UniProt: Q7Z2Z1
Entrez ID: 90381
|
Does Knockout of RGSL1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
RGSL1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: RGSL1 (regulator of G protein signaling like 1)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: G alpha (i) signalling events, G alpha (q) signalling events, G alpha (z) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: A5PLK6
Entrez ID: 353299
|
Does Knockout of PCNA in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
PCNA
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: PCNA (proliferating cell nuclear antigen)
Type: protein-coding
Summary: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, base-excision repair, gap-filling, cellular response to UV, cellular response to hydrogen peroxide, cellular response to xenobiotic stimulus, chromatin organization, epithelial cell differentiation, estrous cycle, heart development, leading strand elongation, liver regeneration, mismatch repair, mitotic telomere maintenance via semi-conservative replication, negative regulation of transcription by RNA polymerase II, positive regulation of DNA repair, positive regulation of DNA replication, positive regulation of DNA-directed DNA polymerase activity, positive regulation of deoxyribonuclease activity, regulation of DNA replication, replication fork processing, response to L-glutamate, response to cadmium ion, response to dexamethasone, response to estradiol, response to lipid, response to oxidative stress, translesion synthesis; MF: DNA binding, DNA polymerase binding, DNA polymerase processivity factor activity, MutLalpha complex binding, chromatin binding, damaged DNA binding, dinucleotide insertion or deletion binding, enzyme binding, histone acetyltransferase binding, identical protein binding, nuclear estrogen receptor binding, protein binding, protein-containing complex binding, purine-specific mismatch base pair DNA N-glycosylase activity, receptor tyrosine kinase binding; CC: PCNA complex, PCNA-p21 complex, centrosome, chromatin, chromosome, telomeric region, cyclin-dependent protein kinase holoenzyme complex, extracellular exosome, male germ cell nucleus, nuclear body, nuclear lamina, nuclear replication fork, nucleoplasm, nucleus, replication fork, replisome
Pathways: 16p11.2 proximal deletion syndrome, BARD1 signaling events, Base Excision Repair, Base excision repair - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Direct p53 effectors, Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, EGF-EGFR signaling pathway, Extension of Telomeres, G0 and Early G1, G1 to S cell cycle control, G1/S Transition, G1/S-Specific Transcription, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Metabolism of proteins, Mismatch Repair, Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair - Homo sapiens (human), Mitotic G1 phase and G1/S transition, Nucleotide Excision Repair, Nucleotide Excision Repair , Nucleotide excision repair - Homo sapiens (human), Oxidative Damage, PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Post-translational protein modification, Primary focal segmental glomerulosclerosis (FSGS), Processive synthesis on the C-strand of the telomere, Processive synthesis on the lagging strand, Protein ubiquitination, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Removal of the Flap Intermediate, Removal of the Flap Intermediate from the C-strand, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), Retinoblastoma gene in cancer, S Phase, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Senescence and Autophagy in Cancer, Synthesis of DNA, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Tight junction - Homo sapiens (human), Transcription of E2F targets under negative control by DREAM complex, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Validated nuclear estrogen receptor alpha network, il-2 receptor beta chain in t cell activation, p53 signaling pathway
UniProt: P12004
Entrez ID: 5111
|
Does Knockout of ZNF670 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
ZNF670
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: ZNF670 (zinc finger protein 670)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: lipid metabolic process, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9BS34
Entrez ID: 93474
|
Does Knockout of NAPG in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
NAPG
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: NAPG (NSF attachment protein gamma)
Type: protein-coding
Summary: This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008].
Gene Ontology: BP: intra-Golgi vesicle-mediated transport, intracellular protein transport, membrane fusion, protein stabilization, protein transport, protein-containing complex assembly, vesicle-mediated transport; MF: protein binding, soluble NSF attachment protein activity, syntaxin binding; CC: Golgi apparatus, SNARE complex, extracellular exosome, lysosomal membrane, membrane, mitochondrion
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q99747
Entrez ID: 8774
|
Does Knockout of EIF3D in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
EIF3D
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: EIF3D (eukaryotic translation initiation factor 3 subunit D)
Type: protein-coding
Summary: Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: IRES-dependent viral translational initiation, cap-dependent translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, translation, translational initiation, viral translational termination-reinitiation; MF: RNA binding, mRNA cap binding, protein binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3m, membrane, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, VEGFA-VEGFR2 Signaling Pathway, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: O15371
Entrez ID: 8664
|
Does Activation of RPL37A in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
RPL37A
|
response to virus
|
Hepatoma Cell Line
|
Gene: RPL37A (ribosomal protein L37a)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, metal ion binding, protein binding, structural constituent of ribosome, zinc ion binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, nucleus, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P61513
Entrez ID: 6168
|
Does Knockout of HTRA1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
HTRA1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: HTRA1 (HtrA serine peptidase 1)
Type: protein-coding
Summary: This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chorionic trophoblast cell differentiation, negative regulation of BMP signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway, placenta development, positive regulation of apoptotic process, programmed cell death, proteolysis; MF: growth factor binding, hydrolase activity, identical protein binding, molecular function activator activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, cytosol, extracellular exosome, extracellular matrix, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Degradation of the extracellular matrix, Extracellular matrix organization, VEGFA-VEGFR2 Signaling Pathway
UniProt: Q92743
Entrez ID: 5654
|
Does Inhibition of NRF1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
NRF1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NRF1 (nuclear respiratory factor 1)
Type: protein-coding
Summary: This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for 'nuclear factor (erythroid-derived 2)-like 1' which has an official symbol of NFE2L1. [provided by RefSeq, May 2014].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, protein homodimerization activity; CC: cytosol, extracellular exosome, nucleoplasm, nucleus
Pathways: Apelin signaling pathway - Homo sapiens (human), Energy Metabolism, Huntington disease - Homo sapiens (human), Mitochondrial Gene Expression, Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway
UniProt: Q16656
Entrez ID: 4899
|
Does Knockout of VPS18 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
VPS18
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: VPS18 (VPS18 core subunit of CORVET and HOPS complexes)
Type: protein-coding
Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: autophagy, endosomal vesicle fusion, endosome organization, endosome to lysosome transport, intracellular protein transport, lysosome organization, negative regulation of intracellular estrogen receptor signaling pathway, organelle fusion, protein transport, protein ubiquitination, regulation of SNARE complex assembly, regulation of synaptic vesicle exocytosis, symbiont entry into host cell, vesicle docking involved in exocytosis, vesicle-mediated transport; MF: actin binding, metal ion binding, protein binding, protein-macromolecule adaptor activity, syntaxin binding, ubiquitin protein ligase activity, zinc ion binding; CC: AP-3 adaptor complex, CORVET complex, HOPS complex, actin filament, autophagosome, clathrin-coated vesicle, cytoplasmic vesicle, early endosome, endomembrane system, endosome, endosome membrane, glutamatergic synapse, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, presynapse
Pathways: Disease, Ebola Virus Pathway on Host, Infectious disease, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates autophagy, SARS-CoV-2-host interactions, Salmonella infection - Homo sapiens (human), Viral Infection Pathways
UniProt: Q9P253
Entrez ID: 57617
|
Does Knockout of HBS1L in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
HBS1L
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: HBS1L (HBS1 like translational GTPase)
Type: protein-coding
Summary: This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009].
Gene Ontology: BP: negative regulation of gene expression, nuclear-transcribed mRNA catabolic process, no-go decay, regulation of translation, rescue of stalled ribosome, ribosome disassembly, signal transduction, translation, translational elongation; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding, translation elongation factor activity; CC: Dom34-Hbs1 complex, cytoplasm, cytosol, cytosolic ribosome, extracellular exosome, membrane
Pathways: Legionellosis - Homo sapiens (human), Metabolism of proteins, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosome-associated quality control, Translation, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9Y450
Entrez ID: 10767
|
Does Knockout of NDUFB1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
NDUFB1
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: NDUFB1 (NADH:ubiquinone oxidoreductase subunit B1)
Type: protein-coding
Summary: Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion and nuclear speck. Part of mitochondrial respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: NADH dehydrogenase (ubiquinone) activity; CC: membrane, mitochondrial inner membrane, mitochondrion, nuclear speck, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human)
UniProt: O75438
Entrez ID: 4707
|
Does Knockout of ANKRD30A in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
ANKRD30A
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ANKRD30A (ankyrin repeat domain 30A)
Type: protein-coding
Summary: This gene encodes a DNA-binding transcription factor that is uniquely expressed in mammary epithelium and the testis. Altered expression levels have been associated with breast cancer progression. [provided by RefSeq, Nov 2016].
Gene Ontology:
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Developmental Lineage of Mammary Gland Alveolar Cells, Developmental Lineage of Mammary Gland Luminal Epithelial Cells, Developmental Lineages of the Mammary Gland
UniProt: Q9BXX3
Entrez ID: 91074
|
Does Knockout of FAM149B1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
FAM149B1
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: FAM149B1 (family with sequence similarity 149 member B1)
Type: protein-coding
Summary: Involved in cilium assembly and protein localization to cilium. Predicted to be located in cilium. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell projection organization, cilium assembly, protein localization to cilium; CC: cell projection, cilium
Pathways:
UniProt: Q96BN6
Entrez ID: 317662
|
Does Knockout of SASS6 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
SASS6
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: SASS6 (SAS-6 centriolar assembly protein)
Type: protein-coding
Summary: The protein encoded by this gene is a central component of centrioles and is necessary for their duplication and function. Centrioles adopt a cartwheel-shaped structure, with the encoded protein forming the hub and spokes inside a microtubule cylinder. Defects in this gene are a cause of autosomal recessive primary microcephaly. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: centriole replication, centrosome duplication, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of centriole replication, positive regulation of spindle assembly, regulation of mitotic spindle organization, spermatogenesis; CC: centriole, centrosome, cytoplasm, cytoskeleton, deuterosome, procentriole replication complex
Pathways: Genes related to primary cilium development (based on CRISPR)
UniProt: Q6UVJ0
Entrez ID: 163786
|
Does Activation of TGIF2LY in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
TGIF2LY
|
protein/peptide accumulation
|
T cell
|
Gene: TGIF2LY (TGFB induced factor homeobox 2 like Y-linked)
Type: protein-coding
Summary: This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. This gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. The C-terminus of this protein is divergent from that of its chromosome X homolog (TGIF2LX), suggesting that this protein may act as a regulator of TGIF2LX. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: Q8IUE0
Entrez ID: 90655
|
Does Knockout of CDK4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
CDK4
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: CDK4 (cyclin dependent kinase 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, cellular response to interleukin-4, cellular response to ionomycin, cellular response to lipopolysaccharide, cellular response to phorbol 13-acetate 12-myristate, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of fibroblast proliferation, regulation of G2/M transition of mitotic cell cycle, regulation of cell cycle, regulation of gene expression, regulation of transcription initiation by RNA polymerase II, regulation of type B pancreatic cell proliferation, response to xenobiotic stimulus, signal transduction; MF: ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: bicellular tight junction, chromatin, cyclin D1-CDK4 complex, cyclin D2-CDK4 complex, cyclin D3-CDK4 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus, transcription regulator complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), ATF-2 transcription factor network, Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects, Aberrant regulation of mitotic cell cycle due to RB1 defects, Adaptive Immune System, Adipogenesis, BCR, Bladder cancer, Bladder cancer - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Homo sapiens (human), Chromatin modifying enzymes, Chromatin organization, Chronic myeloid leukemia - Homo sapiens (human), Co-inhibition by PD-1, Cushing syndrome - Homo sapiens (human), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA damage response, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3), Developmental Biology, Disease, Diseases of Cellular Senescence, Diseases of cellular response to stress, Diseases of mitotic cell cycle, Drug-mediated inhibition of CDK4/CDK6 activity, Epstein-Barr virus infection - Homo sapiens (human), Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4, Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6, Evasion of Oncogene Induced Senescence Due to p16INK4A Defects, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6, Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects, FOXM1 transcription factor network, G1 Phase, G1 to S cell cycle control, G1/S Transition, Gene expression (Transcription), Generic Transcription Pathway, Glioblastoma signaling pathways, Glioma - Homo sapiens (human), H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity, Head and Neck Squamous Cell Carcinoma, Hepatitis C - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Influenza A - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Measles - Homo sapiens (human), Meiosis, Meiotic recombination, Melanoma, Melanoma - Homo sapiens (human), Mitotic G1 phase and G1/S transition, Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Nuclear Receptors Meta-Pathway, Oncogene Induced Senescence, Ovarian infertility, Oxidative Stress Induced Senescence, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PPAR-alpha pathway, PTK6 Regulates Cell Cycle, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), RMTs methylate histone arginines, RNA Polymerase II Transcription, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Regulation of nuclear SMAD2/3 signaling, Regulation of retinoblastoma protein, Reproduction, Retinoblastoma gene in cancer, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Senescence-Associated Secretory Phenotype (SASP), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Spinal Cord Injury, T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, TGF_beta_Receptor, The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, Thyroid stimulating hormone (TSH) signaling pathway, Tight junction - Homo sapiens (human), Transcriptional regulation by RUNX2, Transcriptional regulation of granulopoiesis, Transcriptional regulation of white adipocyte differentiation, Tumor suppressor activity of SMARCB1, Ubiquitin-dependent degradation of Cyclin D, Validated targets of C-MYC transcriptional activation, Viral carcinogenesis - Homo sapiens (human), cell cycle: g1/s check point, cyclins and cell cycle regulation, estrogen responsive protein efp controls cell cycle and breast tumors growth, influence of ras and rho proteins on g1 to s transition, miRNA regulation of DNA damage response, p53 signaling pathway, p53 signaling pathway - Homo sapiens (human), rb tumor suppressor/checkpoint signaling in response to dna damage
UniProt: P11802
Entrez ID: 1019
|
Does Knockout of CCT4 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
CCT4
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CCT4 (chaperonin containing TCP1 subunit 4)
Type: protein-coding
Summary: The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of protein localization to Cajal body, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, scaRNA localization to Cajal body; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, RNA binding, hydrolase activity, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, cell projection, centrosome, chaperonin-containing T-complex, cytoplasm, cytoskeleton, cytosol, extracellular exosome, melanosome, microtubule, nucleoplasm, zona pellucida receptor complex
Pathways: 16p11.2 proximal deletion syndrome, Association of TriC/CCT with target proteins during biosynthesis, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Chaperonin-mediated protein folding, Cilium Assembly, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Folding of actin by CCT/TriC, Formation of tubulin folding intermediates by CCT/TriC, Metabolism of proteins, Organelle biogenesis and maintenance, Prefoldin mediated transfer of substrate to CCT/TriC, Protein folding, b cell survival pathway
UniProt: P50991
Entrez ID: 10575
|
Does Knockout of SCRIB in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
SCRIB
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: SCRIB (scribble planar cell polarity protein)
Type: protein-coding
Summary: This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: activation of GTPase activity, apoptotic process involved in morphogenesis, astrocyte cell migration, auditory receptor cell morphogenesis, auditory receptor cell stereocilium organization, cell differentiation, cell migration, cell population proliferation, cell-cell adhesion, cochlear nucleus development, epithelial structure maintenance, establishment of T cell polarity, establishment of apical/basal cell polarity, establishment of cell polarity, establishment or maintenance of apical/basal cell polarity, establishment or maintenance of epithelial cell apical/basal polarity, inner ear receptor cell stereocilium organization, intracellular protein localization, mammary gland duct morphogenesis, morphogenesis of embryonic epithelium, negative regulation of activated T cell proliferation, negative regulation of mitotic cell cycle, negative regulation of translational initiation, neural tube closure, neurotransmitter receptor transport, endosome to postsynaptic membrane, polarized epithelial cell differentiation, positive chemotaxis, positive regulation of apoptotic process, positive regulation of epithelial to mesenchymal transition, positive regulation of receptor recycling, positive regulation of type II interferon production, post-anal tail morphogenesis, protein localization to adherens junction, receptor clustering, regulation of postsynaptic neurotransmitter receptor internalization, regulation of translation, synaptic vesicle endocytosis, synaptic vesicle targeting, vesicle-mediated transport in synapse, wound healing; MF: cadherin binding, protein binding, protein kinase binding, signaling adaptor activity; CC: Scrib-APC-beta-catenin complex, adherens junction, anchoring junction, basolateral plasma membrane, cell junction, cell leading edge, cell projection, cell-cell contact zone, cell-cell junction, cytoplasm, extracellular exosome, extrinsic component of postsynaptic density membrane, glutamatergic synapse, immunological synapse, lamellipodium, membrane, myelin sheath abaxonal region, nucleoplasm, plasma membrane, postsynapse, postsynaptic density, postsynaptic membrane, presynapse, presynaptic membrane, synapse
Pathways: Asymmetric localization of PCP proteins, Beta-catenin independent WNT signaling, CDC42 GTPase cycle, EGFR1, Hippo signaling pathway - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), PCP/CE pathway, RHO GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, TSH, Thyroid stimulating hormone (TSH) signaling pathway, Tight junction - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human)
UniProt: Q14160
Entrez ID: 23513
|
Does Knockout of GPBP1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
GPBP1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: GPBP1 (GC-rich promoter binding protein 1)
Type: protein-coding
Summary: This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: DNA-templated transcription, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, RNA binding, protein binding; CC: cytoplasm, cytosol, nucleus, plasma membrane
Pathways:
UniProt: Q86WP2
Entrez ID: 65056
|
Does Knockout of SNRPD1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
SNRPD1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide)
Type: protein-coding
Summary: This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
Gene Ontology: BP: 7-methylguanosine cap hypermethylation, RNA processing, RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, spliceosomal complex assembly, spliceosomal snRNP assembly; MF: RNA binding, U1 snRNP binding, protein binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, commitment complex, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, pICln-Sm protein complex, precatalytic spliceosome, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Disease, Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, Spliceosome - Homo sapiens (human), Systemic lupus erythematosus - Homo sapiens (human), Viral Infection Pathways, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62314
Entrez ID: 6632
|
Does Knockout of RPS5 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
RPS5
|
cell proliferation
|
T-lymphoma cell line
|
Gene: RPS5 (ribosomal protein S5)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, regulation of translational fidelity, ribosomal small subunit biogenesis, translation, translational initiation; MF: RNA binding, mRNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46782
Entrez ID: 6193
|
Does Knockout of EXOC6 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
EXOC6
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: EXOC6 (exocyst complex component 6)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: Golgi to plasma membrane transport, exocytosis, intracellular protein transport, membrane fission, mitotic cytokinesis, protein transport, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; CC: Flemming body, cell projection, cytoplasm, cytosol, exocyst, growth cone, perinuclear region of cytoplasm, plasma membrane
Pathways: Arf6 trafficking events, Cargo trafficking to the periciliary membrane, Ciliary landscape, Cilium Assembly, Insulin Pathway, Insulin processing, Membrane Trafficking, Metabolism of proteins, Organelle biogenesis and maintenance, Peptide hormone metabolism, Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, Translocation of SLC2A4 (GLUT4) to the plasma membrane, Vesicle-mediated transport, VxPx cargo-targeting to cilium
UniProt: Q8TAG9
Entrez ID: 54536
|
Does Knockout of MAP10 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
MAP10
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: MAP10 (microtubule associated protein 10)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in microtubule cytoskeleton organization; positive regulation of cytokinesis; and regulation of microtubule-based process. Located in microtubule cytoskeleton and midbody. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, cytoplasmic microtubule organization, microtubule cytoskeleton organization, mitotic spindle midzone assembly, positive regulation of cytokinesis, regulation of microtubule-based process; MF: microtubule binding; CC: centrosome, cytoplasm, cytoplasmic microtubule, cytoskeleton, midbody, mitotic spindle midzone, mitotic spindle pole, spindle pole
Pathways:
UniProt: Q9P2G4
Entrez ID: 54627
|
Does Knockout of OR1J1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
OR1J1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: OR1J1 (olfactory receptor family 1 subfamily J member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGS3
Entrez ID: 347168
|
Does Knockout of HNRNPM in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
HNRNPM
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: HNRNPM (heterogeneous nuclear ribonucleoprotein M)
Type: protein-coding
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding, protein domain specific binding; CC: catalytic step 2 spliceosome, extracellular exosome, membrane, nuclear matrix, nucleolus, nucleoplasm, nucleus, paraspeckles, ribonucleoprotein complex, spliceosomal complex, synapse
Pathways: FGFR2 alternative splicing, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Receptor Tyrosine Kinases, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P52272
Entrez ID: 4670
|
Does Knockout of HSF2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
HSF2
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: HSF2 (heat shock transcription factor 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, identical protein binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus
Pathways: Validated nuclear estrogen receptor alpha network
UniProt: Q03933
Entrez ID: 3298
|
Does Knockout of MYO10 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
MYO10
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: MYO10 (myosin X)
Type: protein-coding
Summary: This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: cytoskeleton-dependent intracellular transport, positive regulation of cell-cell adhesion, regulation of cell shape, regulation of filopodium assembly, signal transduction; MF: ATP binding, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, cytoskeletal protein binding, microfilament motor activity, nucleotide binding, phosphatidylinositol-3,4,5-trisphosphate binding, plus-end directed microfilament motor activity, protein binding, protein-containing complex binding, spectrin binding; CC: cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, filopodium, filopodium membrane, filopodium tip, lamellipodium, membrane, myosin complex, neuron projection, neuronal cell body, nucleolus, plasma membrane, ruffle
Pathways: Axon guidance, Developmental Biology, Disease, FCGR3A-mediated phagocytosis, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania phagocytosis, Nervous system development, Netrin-1 signaling, Netrin-mediated signaling events, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation
UniProt: Q9HD67
Entrez ID: 4651
|
Does Activation of ZBTB6 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
ZBTB6
|
protein/peptide accumulation
|
T cell
|
Gene: ZBTB6 (zinc finger and BTB domain containing 6)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q15916
Entrez ID: 10773
|
Does Knockout of ACTG1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
ACTG1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ACTG1 (actin gamma 1)
Type: protein-coding
Summary: Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: angiogenesis, axonogenesis, cell motility, cellular response to type II interferon, maintenance of blood-brain barrier, morphogenesis of a polarized epithelium, platelet aggregation, positive regulation of cell migration, positive regulation of gene expression, positive regulation of wound healing, postsynaptic actin cytoskeleton organization, protein localization to bicellular tight junction, regulation of focal adhesion assembly, regulation of stress fiber assembly, regulation of synaptic vesicle endocytosis, regulation of transepithelial transport, sarcomere organization, tight junction assembly; MF: ATP binding, hydrolase activity, identical protein binding, nucleotide binding, profilin binding, protein binding, protein kinase binding, structural constituent of cytoskeleton, structural constituent of postsynaptic actin cytoskeleton, ubiquitin protein ligase binding; CC: NuA4 histone acetyltransferase complex, Schaffer collateral - CA1 synapse, actin cytoskeleton, actin filament, apical junction complex, apical part of cell, axon, basal body patch, blood microparticle, calyx of Held, cell-cell junction, cytoplasm, cytoskeleton, cytosol, dense body, extracellular exosome, extracellular space, filamentous actin, focal adhesion, membrane, myofibril, nucleus, phagocytic vesicle, plasma membrane, synapse
Pathways: Adherens junction - Homo sapiens (human), Adherens junctions interactions, Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis - Homo sapiens (human), Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Axon guidance, Bacterial invasion of epithelial cells - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cell-extracellular matrix interactions, Clathrin-mediated endocytosis, Common Pathways Underlying Drug Addiction, Developmental Biology, Dilated cardiomyopathy - Homo sapiens (human), Disease, Diseases of signal transduction by growth factor receptors and second messengers, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHB-mediated forward signaling, Ebola Virus Pathway on Host, Extracellular matrix organization, FCGR3A-mediated phagocytosis, Fas ligand pathway and stress induction of heat shock proteins, Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion, Focal adhesion - Homo sapiens (human), Formation of annular gap junctions, Formation of the dystrophin-glycoprotein complex (DGC), Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Gastric acid secretion - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Immune System, Infectious disease, Influenza A - Homo sapiens (human), Innate Immune System, Interaction between L1 and Ankyrins, L1CAM interactions, Leishmania infection, Leishmania phagocytosis, Leukocyte transendothelial migration - Homo sapiens (human), MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Membrane Trafficking, Myometrial relaxation and contraction pathways, Nervous system development, Neutrophil extracellular trap formation - Homo sapiens (human), Non-integrin membrane-ECM interactions, Oncogenic MAPK signaling, Oxytocin signaling pathway - Homo sapiens (human), Paradoxical activation of RAF signaling by kinase inactive BRAF, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Phagosome - Homo sapiens (human), Platelet activation - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases Activate WASPs and WAVEs, RHO GTPases activate IQGAPs, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, Rap1 signaling pathway - Homo sapiens (human), Recycling pathway of L1, Regulation of Actin Cytoskeleton, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Homo sapiens (human), Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by BRAF and RAF1 fusions, Signaling by RAF1 mutants, Signaling by RAS mutants, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Signaling by high-kinase activity BRAF mutants, Signaling by moderate kinase activity BRAF mutants, Signaling downstream of RAS mutants, Striated Muscle Contraction Pathway, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Tight junction - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, VEGFA-VEGFR2 Pathway, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport, Vibrio cholerae infection - Homo sapiens (human), Viral myocarditis - Homo sapiens (human), Yersinia infection - Homo sapiens (human)
UniProt: P63261
Entrez ID: 71
|
Does Knockout of GABRE in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
GABRE
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: GABRE (gamma-aminobutyric acid type A receptor subunit epsilon)
Type: protein-coding
Summary: The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: chloride transmembrane transport, chloride transport, gamma-aminobutyric acid signaling pathway, inhibitory synapse assembly, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of chloride transport, synaptic transmission, GABAergic; MF: GABA-A receptor activity, GABA-gated chloride ion channel activity, benzodiazepine receptor activity, chloride channel activity, extracellular ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity; CC: GABA-A receptor complex, chloride channel complex, dendrite membrane, membrane, plasma membrane, postsynapse, postsynaptic membrane, synapse
Pathways: GABA receptor Signaling, GABAergic synapse - Homo sapiens (human), Morphine addiction - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Nicotine addiction - Homo sapiens (human), Retrograde endocannabinoid signaling - Homo sapiens (human), mBDNF and proBDNF regulation of GABA neurotransmission
UniProt: P78334
Entrez ID: 2564
|
Does Knockout of EIF3C in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
EIF3C
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: EIF3C (eukaryotic translation initiation factor 3 subunit C)
Type: protein-coding
Summary: Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, positive regulation of translation, translation, translational initiation; MF: RNA binding, protein binding, ribosome binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: Q99613
Entrez ID: 8663
|
Does Knockout of INTS11 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
INTS11
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: INTS11 (integrator complex subunit 11)
Type: protein-coding
Summary: The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, regulation of transcription elongation by RNA polymerase II, snRNA 3'-end processing, snRNA processing, transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: RNA endonuclease activity, hydrolase activity, metal ion binding, protein binding; CC: INTAC complex, blood microparticle, cytoplasm, cytosol, integrator complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q5TA45
Entrez ID: 54973
|
Does Knockout of TINF2 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
TINF2
|
cell proliferation
|
Bladder Carcinoma
|
Gene: TINF2 (TERF1 interacting nuclear factor 2)
Type: protein-coding
Summary: This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: negative regulation of epithelial cell proliferation, negative regulation of telomere maintenance via telomerase, positive regulation of telomere maintenance, protein localization to chromosome, telomeric region, regulation of telomere maintenance via telomere lengthening, telomere assembly, telomere capping; MF: DNA binding, protein binding, telomeric DNA binding; CC: chromosome, chromosome, telomeric region, nuclear body, nuclear matrix, nuclear telomere cap complex, nucleoplasm, nucleus, perinucleolar chromocenter, shelterin complex
Pathways: Regulation of Telomerase
UniProt: Q9BSI4
Entrez ID: 26277
|
Does Knockout of USP39 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
USP39
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: USP39 (ubiquitin specific peptidase 39)
Type: protein-coding
Summary: Predicted to enable thiol-dependent deubiquitinase and zinc ion binding activity. Involved in spliceosomal complex assembly. Located in nucleoplasm. Part of U4/U6 x U5 tri-snRNP complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, cell division, mRNA processing, mRNA splicing, via spliceosome, protein deubiquitination, spliceosomal complex assembly; MF: cysteine-type deubiquitinase activity, hydrolase activity, metal ion binding, protein binding, zinc ion binding; CC: U4/U6 x U5 tri-snRNP complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q53GS9
Entrez ID: 10713
|
Does Knockout of SETDB1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
SETDB1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: SETDB1 (SET domain bifurcated histone lysine methyltransferase 1)
Type: protein-coding
Summary: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, chromatin organization, heterochromatin organization, methylation, negative regulation of gene expression, transposable element silencing by heterochromatin formation; MF: DNA binding, chromatin binding, histone H3 methyltransferase activity, histone H3K9 methyltransferase activity, histone H3K9 monomethyltransferase activity, histone H3K9 trimethyltransferase activity, histone H3K9me2 methyltransferase activity, histone methyltransferase activity, metal ion binding, methyltransferase activity, promoter-specific chromatin binding, protein binding, transferase activity, zinc ion binding; CC: chromosome, cytoplasm, nucleoplasm, nucleus
Pathways: Histone Modifications, Lysine degradation - Homo sapiens (human), Noncanonical Wnt signaling pathway, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
UniProt: Q15047
Entrez ID: 9869
|
Does Knockout of PKHD1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
PKHD1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: PKHD1 (PKHD1 ciliary IPT domain containing fibrocystin/polyductin)
Type: protein-coding
Summary: The protein encoded by this gene is predicted to have a single transmembrane (TM)-spanning domain and multiple copies of an immunoglobulin-like plexin-transcription-factor domain. Alternative splicing results in two transcript variants encoding different isoforms. Other alternatively spliced transcripts have been described, but the full length sequences have not been determined. Several of these transcripts are predicted to encode truncated products which lack the TM and may be secreted. Mutations in this gene cause autosomal recessive polycystic kidney disease, also known as polycystic kidney and hepatic disease-1. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: branching morphogenesis of an epithelial tube, cell-cell adhesion, cell-cell junction organization, cilium assembly, epithelial cell morphogenesis, establishment of centrosome localization, establishment of mitotic spindle orientation, homeostatic process, intracellular calcium ion homeostasis, kidney development, negative regulation of NF-kappaB transcription factor activity, negative regulation of apoptotic process, negative regulation of epithelial cell apoptotic process, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, regulation of ERK1 and ERK2 cascade, regulation of TOR signaling, regulation of cell adhesion, regulation of cell-cell adhesion, regulation of cell-matrix adhesion, regulation of centrosome duplication, regulation of cholangiocyte proliferation, regulation of establishment of planar polarity; MF: protein binding, signaling receptor activity; CC: 9+0 non-motile cilium, Golgi apparatus, apical plasma membrane, cell projection, centrosome, chromosome, chromosome, centromeric region, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum, external side of plasma membrane, extracellular exosome, extracellular region, membrane, mitotic spindle, nucleus, perinuclear region of cytoplasm, plasma membrane, spindle
Pathways: Ciliopathies
UniProt: P08F94
Entrez ID: 5314
|
Does Knockout of DLD in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
DLD
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: DLD (dihydrolipoamide dehydrogenase)
Type: protein-coding
Summary: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: 2-oxoglutarate decarboxylation to succinyl-CoA, 2-oxoglutarate metabolic process, branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA, branched-chain amino acid catabolic process, gastrulation, mitochondrial electron transport, NADH to ubiquinone, proteolysis, pyruvate decarboxylation to acetyl-CoA, pyruvate metabolic process, regulation of membrane potential, sperm capacitation; MF: dihydrolipoyl dehydrogenase (NADH) activity, flavin adenine dinucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor, protein binding; CC: acetyltransferase complex, acrosomal matrix, acrosomal vesicle, branched-chain alpha-ketoacid dehydrogenase complex, cell projection, cilium, cytoplasm, cytoplasmic vesicle, mitochondrial matrix, mitochondrion, motile cilium, nucleus, oxoadipate dehydrogenase complex, oxoglutarate dehydrogenase complex, pyruvate dehydrogenase complex
Pathways: 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency, 2-aminoadipic 2-oxoadipic aciduria, 2-ketoglutarate dehydrogenase complex deficiency, 2-oxobutanoate degradation, 2-oxoglutarate decarboxylation to succinyl-CoA, 2-oxoisovalerate decarboxylation to isobutanoyl-CoA, 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency, 3-Methylcrotonyl Coa Carboxylase Deficiency Type I, 3-Methylglutaconic Aciduria Type I, 3-Methylglutaconic Aciduria Type III, 3-Methylglutaconic Aciduria Type IV, 3-Phosphoglycerate dehydrogenase deficiency, 3-hydroxyisobutyric acid dehydrogenase deficiency, 3-hydroxyisobutyric aciduria, Aerobic respiration and respiratory electron transport, Amino Acid metabolism, Ammonia Recycling, BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV, Beta-Ketothiolase Deficiency, Branched-chain amino acid catabolism, Branched-chain ketoacid dehydrogenase kinase deficiency, Citrate cycle (TCA cycle) - Homo sapiens (human), Citric Acid Cycle, Citric acid cycle (TCA cycle), Congenital lactic acidosis, Dihydropyrimidine Dehydrogenase Deficiency (DHPD), Dimethylglycine Dehydrogenase Deficiency, Disease, Diseases of branched-chain amino acid catabolism, Diseases of metabolism, Fatty acid beta-oxidation, Fumarase deficiency, Glutaminolysis and Cancer, Glutaric Aciduria Type I, Glycine and Serine Metabolism, Glycine degradation, Glycine, serine and threonine metabolism - Homo sapiens (human), Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, Glyoxylate and dicarboxylate metabolism - Homo sapiens (human), Glyoxylate metabolism and glycine degradation, H139Hfs13* PPM1K causes a mild variant of MSUD, Hyperglycinemia, non-ketotic, Hyperlysinemia I, Familial, Hyperlysinemia II or Saccharopinuria, Isobutyryl-coa dehydrogenase deficiency, Isovaleric Aciduria, Isovaleric acidemia, Leigh Syndrome, Loss-of-function mutations in DBT cause MSUD2, Loss-of-function mutations in DLD cause MSUD3/DLDD, Lysine Degradation, Lysine catabolism, Lysine degradation - Homo sapiens (human), Maple Syrup Urine Disease, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Methylmalonate Semialdehyde Dehydrogenase Deficiency, Methylmalonic Aciduria, Mitochondrial complex II deficiency, Mitochondrial protein degradation, Non Ketotic Hyperglycinemia, OADH complex synthesizes glutaryl-CoA from 2-OA, OGDH complex synthesizes succinyl-CoA from 2-OG, PDH complex synthesizes acetyl-CoA from PYR, Primary hyperoxaluria II, PH2, Propanoate metabolism - Homo sapiens (human), Propionic Acidemia, Pyridoxine dependency with seizures, Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency), Pyruvate Dehydrogenase Complex Deficiency, Pyruvate Metabolism, Pyruvate dehydrogenase deficiency (E2), Pyruvate dehydrogenase deficiency (E3), Pyruvate kinase deficiency, Pyruvate metabolism, Pyruvate metabolism - Homo sapiens (human), Regulation of pyruvate dehydrogenase (PDH) complex, Regulation of pyruvate metabolism, Saccharopinuria/Hyperlysinemia II, Sarcosinemia, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, TCA Cycle (aka Krebs or citric acid cycle), TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc), TCA cycle, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate, Threonine and 2-Oxobutanoate Degradation, Tryptophan metabolism - Homo sapiens (human), Valine, Leucine and Isoleucine Degradation, Valine, leucine and isoleucine degradation - Homo sapiens (human), Warburg Effect, glycine cleavage, isoleucine degradation, leucine degradation, pyruvate decarboxylation to acetyl CoA, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle, superpathway of methionine degradation, threonine degradation, valine degradation
UniProt: P09622
Entrez ID: 1738
|
Does Knockout of ATF4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
ATF4
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ATF4 (activating transcription factor 4)
Type: protein-coding
Summary: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: GDF15-GFRAL signaling pathway, HRI-mediated signaling, L-asparagine metabolic process, PERK-mediated unfolded protein response, bone mineralization, cellular response to UV, cellular response to amino acid starvation, cellular response to glucose starvation, cellular response to hypoxia, cellular response to leucine starvation, cellular response to oxidative stress, circadian regulation of gene expression, circadian rhythm, embryonic hemopoiesis, endoplasmic reticulum unfolded protein response, gamma-aminobutyric acid signaling pathway, gluconeogenesis, integrated stress response signaling, intracellular calcium ion homeostasis, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, lens fiber cell morphogenesis, mRNA transcription by RNA polymerase II, mitochondrial respirasome assembly, negative regulation of cold-induced thermogenesis, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of potassium ion transport, negative regulation of transcription by RNA polymerase II, negative regulation of translational initiation in response to stress, neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of biomineral tissue development, positive regulation of gene expression, positive regulation of neuron apoptotic process, positive regulation of sodium-dependent phosphate transport, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular endothelial growth factor production, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of osteoblast differentiation, regulation of synaptic plasticity, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to manganese-induced endoplasmic reticulum stress, response to nutrient levels, response to toxic substance, rhythmic process, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding protein binding, general transcription initiation factor binding, identical protein binding, leucine zipper domain binding, promoter-specific chromatin binding, protein binding, protein heterodimerization activity, protein kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: ATF1-ATF4 transcription factor complex, ATF4-CREB1 transcription factor complex, CHOP-ATF4 complex, Lewy body core, RNA polymerase II transcription regulator complex, centrosome, chromatin, cytoplasm, cytoskeleton, cytosol, dendrite membrane, membrane, mitochondrion, neuron projection, nuclear periphery, nuclear speck, nucleoplasm, nucleus, plasma membrane, protein-containing complex, transcription regulator complex
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, ATF6 (ATF6-alpha) activates chaperone genes, ATF6 (ATF6-alpha) activates chaperones, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alcoholism - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Amphetamine addiction - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis - Homo sapiens (human), Cellular response to chemical stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Cholinergic synapse - Homo sapiens (human), Cocaine addiction - Homo sapiens (human), Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Dopaminergic synapse - Homo sapiens (human), Estrogen signaling pathway - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glucagon signaling pathway - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Joubert Syndrome, KEAP1-NFE2L2 pathway, Lipid and atherosclerosis - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), Longevity regulating pathway - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mitophagy - animal - Homo sapiens (human), Myometrial relaxation and contraction pathways, NFE2L2 regulating ER-stress associated genes, NFE2L2 regulating anti-oxidant/detoxification enzymes, Neurotrophin signaling pathway - Homo sapiens (human), Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Nuclear events mediated by NFE2L2, PERK regulates gene expression, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Photodynamic therapy-induced unfolded protein response, Prion disease - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Renin-angiotensin-aldosterone system (RAAS), Response of EIF2AK1 (HRI) to heme deficiency, Response of EIF2AK4 (GCN2) to amino acid deficiency, TNF signaling pathway - Homo sapiens (human), Thyroid hormone synthesis - Homo sapiens (human), Unfolded Protein Response (UPR), Unfolded protein response, VEGFA-VEGFR2 Signaling Pathway, Validated transcriptional targets of AP1 family members Fra1 and Fra2, Viral carcinogenesis - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P18848
Entrez ID: 468
|
Does Knockout of BRF1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
BRF1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: BRF1 (BRF1 general transcription factor IIIB subunit)
Type: protein-coding
Summary: This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: DNA-templated transcription initiation, rRNA transcription, tRNA transcription, transcription by RNA polymerase III, transcription initiation at RNA polymerase III promoter, transcription preinitiation complex assembly; MF: RNA polymerase III general transcription initiation factor activity, RNA polymerase III type 3 promoter sequence-specific DNA binding, TBP-class protein binding, metal ion binding, protein binding, zinc ion binding; CC: nucleoplasm, nucleus, transcription factor TFIIIB complex, transcription preinitiation complex
Pathways: Gene expression (Transcription), RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, rna polymerase iii transcription
UniProt: Q92994
Entrez ID: 2972
|
Does Knockout of FCF1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
FCF1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: FCF1 (FCF1 rRNA-processing protein)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Predicted to act upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding; CC: nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y324
Entrez ID: 51077
|
Does Knockout of RSL1D1 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
RSL1D1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: RSL1D1 (ribosomal L1 domain containing 1)
Type: protein-coding
Summary: Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in regulation of apoptotic process and regulation of cellular senescence. Acts upstream of or within regulation of protein localization. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: osteoblast differentiation, regulation of apoptotic process, regulation of cellular senescence, regulation of protein localization; MF: RNA binding, cadherin binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, protein binding; CC: chromosome, cilium, cytosol, membrane, nucleolus, nucleus
Pathways: Senescence and Autophagy in Cancer
UniProt: O76021
Entrez ID: 26156
|
Does Knockout of AGAP9 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
AGAP9
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: AGAP9 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 9)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in regulation of catalytic activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase activator activity, GTPase activity, metal ion binding, zinc ion binding
Pathways: Endocytosis - Homo sapiens (human)
UniProt: Q5VTM2
Entrez ID: 642517
|
Does Knockout of PAK3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
PAK3
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: PAK3 (p21 (RAC1) activated kinase 3)
Type: protein-coding
Summary: The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: MAPK cascade, axonogenesis, cell migration, cell surface receptor protein tyrosine kinase signaling pathway, cellular response to starvation, dendrite development, dendritic spine development, dendritic spine morphogenesis, ephrin receptor signaling pathway, intracellular signal transduction, regulation of MAPK cascade, regulation of actin cytoskeleton organization, regulation of actin filament organization, regulation of actin filament polymerization, regulation of axonogenesis, regulation of postsynapse organization, stimulatory C-type lectin receptor signaling pathway, synapse organization; MF: ATP binding, MAP kinase kinase activity, SH3 domain binding, catalytic activity, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, small GTPase binding, transferase activity; CC: cytoplasm, cytosol, glutamatergic synapse, plasma membrane, postsynaptic density
Pathways: Activation of RAC1, Adaptive Immune System, Axon guidance, Axon guidance - Homo sapiens (human), C-type lectin receptors (CLRs), CD209 (DC-SIGN) signaling, CD28 dependent Vav1 pathway, CDC42 GTPase cycle, Co-stimulation by CD28, Developmental Biology, EPH-Ephrin signaling, Ephrin signaling, ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), Focal Adhesion, Focal adhesion - Homo sapiens (human), G13 Signaling Pathway, Generation of second messenger molecules, Hippo-Merlin Signaling Dysregulation, Human immunodeficiency virus 1 infection - Homo sapiens (human), Immune System, Innate Immune System, Integrin-mediated Cell Adhesion, MAPK family signaling cascades, MAPK6/MAPK4 signaling, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Nervous system development, Neural Crest Cell Migration during Development, Neural Crest Cell Migration in Cancer, Pancreatic adenocarcinoma pathway, Pathogenic Escherichia coli infection - Homo sapiens (human), RAC1 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases activate PAKs, RHOJ GTPase cycle, RHOU GTPase cycle, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of p38-alpha and p38-beta, Renal cell carcinoma - Homo sapiens (human), Salmonella infection - Homo sapiens (human), Sema3A PAK dependent Axon repulsion, Semaphorin interactions, Signal Transduction, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, T cell receptor signaling pathway - Homo sapiens (human), TCR signaling, VEGFA-VEGFR2 Pathway, VEGFR2 mediated vascular permeability, agrin in postsynaptic differentiation
UniProt: O75914
Entrez ID: 5063
|
Does Knockout of TNPO3 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
TNPO3
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: TNPO3 (transportin 3)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2020].
Gene Ontology: BP: protein import into nucleus, protein transport; MF: identical protein binding, nuclear import signal receptor activity, protein binding, small GTPase binding; CC: annulate lamellae, cytoplasm, cytosol, nuclear envelope, nucleoplasm, nucleus
Pathways:
UniProt: Q9Y5L0
Entrez ID: 23534
|
Does Knockout of MIR193A in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
MIR193A
|
response to virus
|
Hepatoma Cell Line
|
Gene: MIR193A (microRNA 193a)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: DNA damage response, miRNA-mediated gene silencing by mRNA destabilization, miRNA-mediated post-transcriptional gene silencing, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of angiogenesis, negative regulation of blood vessel endothelial cell migration, negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of vascular endothelial cell proliferation; MF: mRNA 3'-UTR binding, mRNA base-pairing post-transcriptional repressor activity
Pathways:
UniProt:
Entrez ID: 406968
|
Does Knockout of NCAPG in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
NCAPG
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: NCAPG (non-SMC condensin I complex subunit G)
Type: protein-coding
Summary: This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: cell division, chromosome condensation, mitotic chromosome condensation, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation; CC: chromosome, condensed chromosome, condensed chromosome, centromeric region, condensed nuclear chromosome, condensin complex, cytoplasm, cytosol, membrane, nucleus
Pathways: Aurora B signaling, Cell Cycle, Cell Cycle, Mitotic, Condensation of Prometaphase Chromosomes, M Phase, Mitotic Prometaphase
UniProt: Q9BPX3
Entrez ID: 64151
|
Does Knockout of SPRYD3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
SPRYD3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SPRYD3 (SPRY domain containing 3)
Type: protein-coding
Summary: Predicted to be involved in cell surface receptor signaling pathway and cytoskeleton organization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q8NCJ5
Entrez ID: 84926
|
Does Knockout of RACGAP1 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
RACGAP1
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: RACGAP1 (Rac GTPase activating protein 1)
Type: protein-coding
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: Rho protein signal transduction, actomyosin contractile ring assembly, cell differentiation, cell division, erythrocyte differentiation, mitotic cytokinesis, mitotic spindle midzone assembly, monoatomic ion transport, neuroblast proliferation, positive regulation of cytokinesis, regulation of attachment of spindle microtubules to kinetochore, regulation of embryonic development, regulation of small GTPase mediated signal transduction, signal transduction, spermatogenesis, sulfate transmembrane transport; MF: GTPase activator activity, alpha-tubulin binding, beta-tubulin binding, gamma-tubulin binding, lipid binding, metal ion binding, microtubule binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein binding, protein kinase binding, protein-macromolecule adaptor activity, zinc ion binding; CC: Flemming body, acrosomal vesicle, centralspindlin complex, cleavage furrow, cytoplasm, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoskeleton, cytosol, extracellular exosome, membrane, microtubule, midbody, mitochondrion, mitotic spindle, nucleoplasm, nucleus, plasma membrane, spindle, spindle midzone
Pathways: Adaptive Immune System, Aurora B signaling, CDC42 GTPase cycle, COPI-dependent Golgi-to-ER retrograde traffic, EGFR1, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, MHC class II antigen presentation, Membrane Trafficking, RAC1 GTPase cycle, RAC1 signaling pathway, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, Regulation of CDC42 activity, Regulation of RAC1 activity, Signal Transduction, Signal Transduction of S1P Receptor, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport, Wnt signaling pathway and pluripotency
UniProt: Q9H0H5
Entrez ID: 29127
|
Does Knockout of PSMB6 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
PSMB6
|
cell proliferation
|
Bladder Carcinoma
|
Gene: PSMB6 (proteasome 20S subunit beta 6)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, proteolysis involved in protein catabolic process; MF: cadherin binding, endopeptidase activity, hydrolase activity, peptidase activity, protein binding, threonine-type endopeptidase activity; CC: cytoplasm, cytosol, extracellular exosome, mitochondrion, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, antigen processing and presentation, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: P28072
Entrez ID: 5694
|
Does Knockout of PSMD2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
PSMD2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of protein catabolic process; MF: enzyme regulator activity, protein binding; CC: cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, base subcomplex, proteasome storage granule, secretory granule lumen
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, Epstein-Barr virus infection - Homo sapiens (human), FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Neutrophil degranulation, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNF-alpha signaling pathway, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint
UniProt: Q13200
Entrez ID: 5708
|
Does Knockout of ITIH2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
ITIH2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2)
Type: protein-coding
Summary: The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009].
Gene Ontology: MF: endopeptidase inhibitor activity, hyaluronic acid binding, peptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity; CC: blood microparticle, endoplasmic reticulum lumen, extracellular exosome, extracellular matrix, extracellular region
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: P19823
Entrez ID: 3698
|
Does Activation of MIEF1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
MIEF1
|
response to virus
|
Hepatoma Cell Line
|
Gene: MIEF1 (mitochondrial elongation factor 1)
Type: protein-coding
Summary: Enables ADP binding activity; GDP binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of mitochondrial fission; positive regulation of mitochondrial translation; and positive regulation of protein targeting to membrane. Located in mitochondrial matrix and mitochondrial outer membrane. Colocalizes with mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mitochondrial fission, mitochondrial fusion, mitochondrion organization, positive regulation of mitochondrial fission, positive regulation of mitochondrial fusion, positive regulation of protein targeting to membrane; MF: ADP binding, GDP binding, identical protein binding, nucleotide binding, protein binding; CC: membrane, mitochondrial outer membrane, mitochondrion, peroxisome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Translation
UniProt: Q9NQG6
Entrez ID: 54471
|
Does Knockout of CDC123 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
CDC123
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: CDC123 (cell division cycle 123)
Type: protein-coding
Summary: Predicted to be involved in eukaryotic translation initiation factor 2 complex assembly and positive regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: eukaryotic translation initiation factor 2 complex assembly, protein folding; MF: ATP binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein folding chaperone; CC: cytoplasm
Pathways:
UniProt: O75794
Entrez ID: 8872
|
Does Knockout of CCDC85C in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
CCDC85C
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CCDC85C (coiled-coil domain containing 85C)
Type: protein-coding
Summary: Predicted to be involved in cerebral cortex development. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Notch signaling pathway, cell population proliferation, cerebral cortex development, establishment of cell polarity, establishment of protein localization, radial glial cell differentiation; CC: adherens junction, anchoring junction, apical junction complex, bicellular tight junction, cell junction, nuclear speck
Pathways:
UniProt: A6NKD9
Entrez ID: 317762
|
Does Knockout of ZNF572 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
ZNF572
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: ZNF572 (zinc finger protein 572)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q7Z3I7
Entrez ID: 137209
|
Does Knockout of ENY2 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
ENY2
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: ENY2 (ENY2 transcription and export complex 2 subunit)
Type: protein-coding
Summary: Enables nuclear receptor coactivator activity. Involved in histone deubiquitination; poly(A)+ mRNA export from nucleus; and positive regulation of transcription, DNA-templated. Located in mitochondrion and nucleoplasm. Part of nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, mRNA export from nucleus, mRNA transport, negative regulation of insulin secretion involved in cellular response to glucose stimulus, poly(A)+ mRNA export from nucleus, positive regulation of DNA-templated transcription, protein transport, regulation of DNA repair, regulation of RNA splicing, regulation of transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: chromatin binding, protein binding, transcription coactivator activity; CC: DUBm complex, SAGA complex, mitochondrion, nuclear pore, nuclear pore nuclear basket, nucleoplasm, nucleus, transcription export complex 2, transcription factor TFTC complex
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q9NPA8
Entrez ID: 56943
|
Does Knockout of NUDT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
NUDT1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: NUDT1 (nudix hydrolase 1)
Type: protein-coding
Summary: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018].
Gene Ontology: BP: DNA protection, DNA repair, purine nucleoside catabolic process, response to oxidative stress; MF: 2-hydroxy-ATP hydrolase activity, 2-hydroxy-dATP hydrolase activity, 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity, 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity, 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity, ATP diphosphatase activity, N6-methyl-(d)ATP hydrolase activity, O6-methyl-dGTP hydrolase activity, RNA binding, dATP diphosphatase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, metal ion binding, protein binding, snoRNA binding; CC: cytoplasm, cytosol, mitochondrial matrix, mitochondrion, nucleus
Pathways: Metabolism, Metabolism of nucleotides, Nucleotide catabolism, Phosphate bond hydrolysis by NUDT proteins, Purine catabolism, oxidized GTP and dGTP detoxification
UniProt: P36639
Entrez ID: 4521
|
Does Knockout of TRAPPC2 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
TRAPPC2
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: TRAPPC2 (trafficking protein particle complex subunit 2)
Type: protein-coding
Summary: The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: COPII vesicle coating, endoplasmic reticulum to Golgi vesicle-mediated transport, skeletal system development, vesicle coating, vesicle tethering, vesicle-mediated transport; MF: protein binding, transmembrane transporter binding; CC: TRAPP complex, TRAPPII protein complex, TRAPPIII protein complex, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: P0DI82, P0DI81
Entrez ID: 6399
|
Does Knockout of NOP16 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
NOP16
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: NOP16 (NOP16 nucleolar protein)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9Y3C1
Entrez ID: 51491
|
Does Knockout of PM20D1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
PM20D1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: PM20D1 (peptidase M20 domain containing 1)
Type: protein-coding
Summary: Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including amide biosynthetic process; cellular amide catabolic process; and negative regulation of neuron death. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: adaptive thermogenesis, amide biosynthetic process, amide catabolic process, amino acid metabolic process, energy homeostasis, fatty acid metabolic process, lipid metabolic process, proteolysis; MF: aminoacylase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, lyase activity, metal ion binding, peptidase activity; CC: extracellular exosome, extracellular region, extracellular space
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Mitochondrial Uncoupling, Oleoyl-phe metabolism
UniProt: Q6GTS8
Entrez ID: 148811
|
Does Knockout of CMBL in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
CMBL
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CMBL (carboxymethylenebutenolidase homolog)
Type: protein-coding
Summary: CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the medoxomil moiety is linked to an oxygen atom (Ishizuka et al., 2010 [PubMed 20177059]).[supplied by OMIM, Apr 2010].
Gene Ontology: MF: hydrolase activity; CC: cytoplasm, cytosol, extracellular exosome
Pathways: Biological oxidations, Metabolism, Phase I - Functionalization of compounds
UniProt: Q96DG6
Entrez ID: 134147
|
Does Knockout of ADK in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
ADK
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: ADK (adenosine kinase)
Type: protein-coding
Summary: This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: AMP salvage, GMP salvage, dAMP salvage, dATP biosynthetic process, purine nucleobase metabolic process, purine ribonucleoside salvage, ribonucleoside monophosphate biosynthetic process; MF: ATP binding, RNA binding, adenosine kinase activity, deoxyadenosine kinase activity, kinase activity, metal ion binding, nucleotide binding, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane
Pathways: Azathioprine Action Pathway, Drug ADME, Mercaptopurine Action Pathway, Mercaptopurine Metabolism Pathway, Metabolism, Metabolism of nucleotides, Methionine metabolism leading to sulfur amino acids and related disorders, Nucleotide salvage, Purine metabolism - Homo sapiens (human), Purine salvage, Ribavirin ADME, Thioguanine Action Pathway, adenine and adenosine salvage II, superpathway of purine nucleotide salvage
UniProt: P55263
Entrez ID: 132
|
Does Knockout of ZNF585B in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
ZNF585B
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: ZNF585B (zinc finger protein 585B)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: developmental process, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q52M93
Entrez ID: 92285
|
Does Knockout of UBE2L3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
UBE2L3
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: UBE2L3 (ubiquitin conjugating enzyme E2 L3)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cell cycle phase transition, cell population proliferation, cellular response to glucocorticoid stimulus, cellular response to steroid hormone stimulus, positive regulation of DNA-templated transcription, positive regulation of protein targeting to mitochondrion, positive regulation of protein ubiquitination, protein K11-linked ubiquitination, protein modification by small protein conjugation, protein modification process, protein polyubiquitination, protein ubiquitination, regulation of DNA-templated transcription, ubiquitin-dependent protein catabolic process; MF: ATP binding, RNA binding, enzyme binding, nucleotide binding, protein binding, transcription coactivator activity, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin protein ligase binding, ubiquitin-like protein transferase activity, ubiquitin-protein transferase activator activity, ubiquitin-protein transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adaptive Immune System, Alpha-synuclein signaling, Antigen processing: Ubiquitination & Proteasome degradation, Autophagy, BARD1 signaling events, Class I MHC mediated antigen processing & presentation, Death Receptor Signaling, E3 ubiquitin ligases ubiquitinate target proteins, Immune System, Macroautophagy, Metabolism of proteins, Mitophagy, PINK1-PRKN Mediated Mitophagy, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Parkinson,s disease pathway, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Programmed Cell Death, Protein ubiquitination, RIPK1-mediated regulated necrosis, Regulated Necrosis, Regulation of TNFR1 signaling, Regulation of necroptotic cell death, Selective autophagy, Signal Transduction, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, TNF signaling, Ubiquitin mediated proteolysis - Homo sapiens (human), role of parkin in ubiquitin-proteasomal pathway
UniProt: P68036
Entrez ID: 7332
|
Does Knockout of NDC80 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
NDC80
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: NDC80 (NDC80 kinetochore complex component)
Type: protein-coding
Summary: This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: G2/MI transition of meiotic cell cycle, attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, centrosome duplication, chromosome organization, chromosome segregation, establishment of mitotic spindle orientation, kinetochore organization, metaphase chromosome alignment, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization, nuclear chromosome segregation, nuclear division, positive regulation of mitotic cell cycle spindle assembly checkpoint, regulation of protein stability, skeletal muscle satellite cell proliferation, spindle assembly involved in female meiosis I, spindle organization; MF: cyclin binding, identical protein binding, kinetochore adaptor activity, microtubule binding, protein binding; CC: Ndc80 complex, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytosol, kinetochore, membrane, nuclear speck, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Aurora B signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, PLK1 signaling events, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O14777
Entrez ID: 10403
|
Does Knockout of FBXW11 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
FBXW11
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: FBXW11 (F-box and WD repeat domain containing 11)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, Wnt signaling pathway, brain morphogenesis, establishment of mitotic spindle orientation, germ cell development, microtubule organizing center organization, negative regulation of canonical NF-kappaB signal transduction, nuclear migration, positive regulation of DNA-templated transcription, positive regulation of canonical NF-kappaB signal transduction, positive regulation of circadian rhythm, positive regulation of proteolysis, proteasome-mediated ubiquitin-dependent protein catabolic process, protein dephosphorylation, protein destabilization, protein polyubiquitination, protein ubiquitination, retrograde axonal transport, rhythmic process, vesicle transport along microtubule; MF: dynein complex binding, microtubule plus-end binding, protein binding, protein dimerization activity, ubiquitin-like ligase-substrate adaptor activity; CC: SCF ubiquitin ligase complex, axon cytoplasm, centrosome, cytoplasm, cytoplasmic microtubule, cytosol, kinetochore, microtubule associated complex, neuron projection, neuronal cell body, nuclear envelope, nucleus, ubiquitin ligase complex
Pathways: Cellular senescence - Homo sapiens (human), Circadian rhythm - Homo sapiens (human), Hedgehog signaling events mediated by Gli proteins, Hedgehog signaling pathway - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Presenilin action in Notch and Wnt signaling, Prolactin, Shigellosis - Homo sapiens (human), Signaling events mediated by VEGFR1 and VEGFR2, TNF-alpha signaling pathway, TNFalpha, Ubiquitin mediated proteolysis - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q9UKB1
Entrez ID: 23291
|
Does Knockout of LCMT1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
LCMT1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: LCMT1 (leucine carboxyl methyltransferase 1)
Type: protein-coding
Summary: LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: C-terminal protein methylation, G2/M transition of mitotic cell cycle, methylation, negative regulation of protein-containing complex assembly, protein methylation, protein modification process, regulation of apoptotic process, regulation of glucose metabolic process, regulation of mitotic cell cycle spindle assembly checkpoint, regulation of signal transduction; MF: S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, protein C-terminal carboxyl O-methyltransferase activity, protein C-terminal leucine carboxyl O-methyltransferase activity, protein binding, protein methyltransferase activity, transferase activity; CC: cytosol, nucleoplasm
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Transition, Mitotic G2-G2/M phases
UniProt: Q9UIC8
Entrez ID: 51451
|
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