prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of PYCR2 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | PYCR2 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: PYCR2 (pyrroline-5-carboxylate reductase 2)
Type: protein-coding
Summary: This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternative... |
Does Knockout of C12orf56 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | C12orf56 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: C12orf56 (chromosome 12 open reading frame 56)
Type: protein-coding
Summary: chromosome 12 open reading frame 56
Gene Ontology:
Pathways:
UniProt: Q8IXR9
Entrez ID: 115749 |
Does Knockout of TOM1L2 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | TOM1L2 | cell proliferation | Cancer Cell Line | Gene: TOM1L2 (target of myb1 like 2 membrane trafficking protein)
Type: protein-coding
Summary: This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by th... |
Does Knockout of PHACTR4 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | PHACTR4 | response to virus | Hepatoma Cell Line | Gene: PHACTR4 (phosphatase and actin regulator 4)
Type: protein-coding
Summary: This gene encodes a member of the phosphatase and actin regulator (PHACTR) family. Other PHACTR family members have been shown to inhibit protein phosphatase 1 (PP1) activity, and the homolog of this gene in the mouse has be... |
Does Knockout of GRWD1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | GRWD1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: GRWD1 (glutamate rich WD repeat containing 1)
Type: protein-coding
Summary: This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with ... |
Does Knockout of SRD5A1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | SRD5A1 | cell proliferation | Colonic Cancer Cell Line | Gene: SRD5A1 (steroid 5 alpha-reductase 1)
Type: protein-coding
Summary: Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: andro... |
Does Knockout of QPRT in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | QPRT | cell proliferation | Medulloblastoma Cell Line | Gene: QPRT (quinolinate phosphoribosyltransferase)
Type: protein-coding
Summary: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quin... |
Does Knockout of CENPL in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | CENPL | cell proliferation | Cancer Cell Line | Gene: CENPL (centromere protein L)
Type: protein-coding
Summary: CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMe... |
Does Knockout of MRPL41 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | MRPL41 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: MRPL41 (mitochondrial ribosomal protein L41)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of RSL24D1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | RSL24D1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: RSL24D1 (ribosomal L24 domain containing 1)
Type: protein-coding
Summary: This gene encodes a protein sharing a low level of sequence similarity with human ribosomal protein L24. Although this gene has been referred to as RPL24, L30, and 60S ribosomal protein L30 isolog in the sequence databases, ... |
Does Knockout of XRN2 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | XRN2 | cell proliferation | Colonic Cancer Cell Line | Gene: XRN2 (5'-3' exoribonuclease 2)
Type: protein-coding
Summary: This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
... |
Does Activation of PXDN in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | PXDN | protein/peptide accumulation | T cell | Gene: PXDN (peroxidasin)
Type: protein-coding
Summary: This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations... |
Does Knockout of RAET1L in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | RAET1L | cell proliferation | Colonic Cancer Cell Line | Gene: RAET1L (retinoic acid early transcript 1L)
Type: protein-coding
Summary: RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extra... |
Does Activation of POSTN in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | POSTN | protein/peptide accumulation | T cell | Gene: POSTN (periostin)
Type: protein-coding
Summary: This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support ad... |
Does Activation of PTGER4 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | PTGER4 | protein/peptide accumulation | T cell | Gene: PTGER4 (prostaglandin E receptor 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been sho... |
Does Knockout of LIN28B in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | LIN28B | response to chemicals | Melanoma Cell Line | Gene: LIN28B (lin-28 RNA binding posttranscriptional regulator B)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fe... |
Does Knockout of ZNF33A in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | ZNF33A | cell proliferation | Hepatoma Cell Line | Gene: ZNF33A (zinc finger protein 33A)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by... |
Does Knockout of MRPS7 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | MRPS7 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: MRPS7 (mitochondrial ribosomal protein S7)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. T... |
Does Knockout of FAHD2A in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | FAHD2A | RNA accumulation | Monocytic Leukemia Cell Line | Gene: FAHD2A (fumarylacetoacetate hydrolase domain containing 2A)
Type: protein-coding
Summary: Predicted to enable hydro-lyase activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: oxaloacetate metabolic process; MF: catalytic activity, isomerase activity, metal ion... |
Does Knockout of MCEE in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | MCEE | cell proliferation | Glioblastoma Cell Line | Gene: MCEE (methylmalonyl-CoA epimerase)
Type: protein-coding
Summary: The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylma... |
Does Knockout of FOXA1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | FOXA1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: FOXA1 (forkhead box A1)
Type: protein-coding
Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. S... |
Does Knockout of ANKRD11 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | ANKRD11 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: ANKRD11 (ankyrin repeat domain containing 11)
Type: protein-coding
Summary: This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characteriz... |
Does Knockout of LRRC19 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | LRRC19 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: LRRC19 (leucine rich repeat containing 19)
Type: protein-coding
Summary: Predicted to enable signaling receptor activity. Acts upstream of or within positive regulation of NIK/NF-kappaB signaling. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided ... |
Does Knockout of SPOUT1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | SPOUT1 | cell proliferation | Medulloblastoma Cell Line | Gene: SPOUT1 (SPOUT domain containing methyltransferase 1)
Type: protein-coding
Summary: Enables miRNA binding activity. Involved in maintenance of centrosome location and production of miRNAs involved in gene silencing by miRNA. Located in kinetochore; mitotic spindle; and spindle pole centrosome. [pro... |
Does Knockout of HEATR4 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | HEATR4 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: HEATR4 (HEAT repeat containing 4)
Type: protein-coding
Summary: Predicted to enable oxidoreductase activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q86WZ0
Entrez ID: 399671 |
Does Knockout of NME5 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | NME5 | response to virus | Huh-7 Cell | Gene: NME5 (NME/NM23 family member 5)
Type: protein-coding
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and spermatid development. Predicted to act upstream of or wit... |
Does Knockout of GNA14 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | GNA14 | cell proliferation | Gastric Cancer Cell Line | Gene: GNA14 (G protein subunit alpha 14)
Type: protein-coding
Summary: This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more spe... |
Does Knockout of B3GALT4 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | B3GALT4 | cell proliferation | Monocytic Leukemia Cell Line | Gene: B3GALT4 (beta-1,3-galactosyltransferase 4)
Type: protein-coding
Summary: This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose an... |
Does Knockout of PREB in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | PREB | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: PREB (prolactin regulatory element binding)
Type: protein-coding
Summary: This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental ab... |
Does Knockout of MOGAT2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | MOGAT2 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: MOGAT2 (monoacylglycerol O-acyltransferase 2)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine.... |
Does Knockout of MYH7B in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 1 | 1,480 | Knockout | MYH7B | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: MYH7B (myosin heavy chain 7B)
Type: protein-coding
Summary: The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular m... |
Does Knockout of HMGCS1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | HMGCS1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1)
Type: protein-coding
Summary: Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytoplasm. Predicted to... |
Does Knockout of TICRR in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | TICRR | cell proliferation | Gastric Cancer Cell Line | Gene: TICRR (TOPBP1 interacting checkpoint and replication regulator)
Type: protein-coding
Summary: Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication,... |
Does Knockout of RGSL1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | RGSL1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: RGSL1 (regulator of G protein signaling like 1)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: G alpha (i) signalling events, G alpha (q) signalling events, G alpha (z) s... |
Does Knockout of PCNA in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | PCNA | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: PCNA (proliferating cell nuclear antigen)
Type: protein-coding
Summary: The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replicatio... |
Does Knockout of ZNF670 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | ZNF670 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: ZNF670 (zinc finger protein 670)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of NAPG in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | NAPG | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: NAPG (NSF attachment protein gamma)
Type: protein-coding
Summary: This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components o... |
Does Knockout of EIF3D in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | EIF3D | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: EIF3D (eukaryotic translation initiation factor 3 subunit D)
Type: protein-coding
Summary: Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain ... |
Does Activation of RPL37A in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | RPL37A | response to virus | Hepatoma Cell Line | Gene: RPL37A (ribosomal protein L37a)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene enco... |
Does Knockout of HTRA1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | HTRA1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: HTRA1 (HtrA serine peptidase 1)
Type: protein-coding
Summary: This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also be... |
Does Inhibition of NRF1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,184 | Inhibition | NRF1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: NRF1 (nuclear respiratory factor 1)
Type: protein-coding
Summary: This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthes... |
Does Knockout of VPS18 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | VPS18 | cell proliferation | Gastric Cancer Cell Line | Gene: VPS18 (VPS18 core subunit of CORVET and HOPS complexes)
Type: protein-coding
Summary: Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) ge... |
Does Knockout of HBS1L in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | HBS1L | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: HBS1L (HBS1 like translational GTPase)
Type: protein-coding
Summary: This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been id... |
Does Knockout of NDUFB1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | NDUFB1 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: NDUFB1 (NADH:ubiquinone oxidoreductase subunit B1)
Type: protein-coding
Summary: Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion and nuclear speck. Part of mitochondrial respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of ANKRD30A in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | ANKRD30A | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ANKRD30A (ankyrin repeat domain 30A)
Type: protein-coding
Summary: This gene encodes a DNA-binding transcription factor that is uniquely expressed in mammary epithelium and the testis. Altered expression levels have been associated with breast cancer progression. [provided by RefSeq, Nov 2016].
... |
Does Knockout of FAM149B1 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | FAM149B1 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: FAM149B1 (family with sequence similarity 149 member B1)
Type: protein-coding
Summary: Involved in cilium assembly and protein localization to cilium. Predicted to be located in cilium. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP:... |
Does Knockout of SASS6 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | SASS6 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: SASS6 (SAS-6 centriolar assembly protein)
Type: protein-coding
Summary: The protein encoded by this gene is a central component of centrioles and is necessary for their duplication and function. Centrioles adopt a cartwheel-shaped structure, with the encoded protein forming the hub and spokes insi... |
Does Activation of TGIF2LY in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | TGIF2LY | protein/peptide accumulation | T cell | Gene: TGIF2LY (TGFB induced factor homeobox 2 like Y-linked)
Type: protein-coding
Summary: This gene encodes a member of the TALE/TGIF homeobox family of transcription factors. This gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a la... |
Does Knockout of CDK4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | CDK4 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: CDK4 (cyclin dependent kinase 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex th... |
Does Knockout of CCT4 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | CCT4 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: CCT4 (chaperonin containing TCP1 subunit 4)
Type: protein-coding
Summary: The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly... |
Does Knockout of SCRIB in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | SCRIB | cell proliferation | Renal Cancer Cell Line | Gene: SCRIB (scribble planar cell polarity protein)
Type: protein-coding
Summary: This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization proc... |
Does Knockout of GPBP1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | GPBP1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: GPBP1 (GC-rich promoter binding protein 1)
Type: protein-coding
Summary: This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice varia... |
Does Knockout of SNRPD1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | SNRPD1 | cell proliferation | Endometrial Cancer Cell Line | Gene: SNRPD1 (small nuclear ribonucleoprotein D1 polypeptide)
Type: protein-coding
Summary: This gene encodes a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interaction... |
Does Knockout of RPS5 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | RPS5 | cell proliferation | T-lymphoma cell line | Gene: RPS5 (ribosomal protein S5)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ... |
Does Knockout of EXOC6 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | EXOC6 | cell proliferation | Breast Cancer Cell Line | Gene: EXOC6 (exocyst complex component 6)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a ... |
Does Knockout of MAP10 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | MAP10 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: MAP10 (microtubule associated protein 10)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in microtubule cytoskeleton organization; positive regulation of cytokinesis; and regulation of microtubule-based process. Located in microtubule cytoskeleton and midbody. [provid... |
Does Knockout of OR1J1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | OR1J1 | cell proliferation | Endometrial Cancer Cell Line | Gene: OR1J1 (olfactory receptor family 1 subfamily J member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of HNRNPM in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | HNRNPM | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: HNRNPM (heterogeneous nuclear ribonucleoprotein M)
Type: protein-coding
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These protei... |
Does Knockout of HSF2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | HSF2 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: HSF2 (heat shock transcription factor 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock resp... |
Does Knockout of MYO10 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | MYO10 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: MYO10 (myosin X)
Type: protein-coding
Summary: This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosi... |
Does Activation of ZBTB6 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | ZBTB6 | protein/peptide accumulation | T cell | Gene: ZBTB6 (zinc finger and BTB domain containing 6)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of t... |
Does Knockout of ACTG1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | ACTG1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ACTG1 (actin gamma 1)
Type: protein-coding
Summary: Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha act... |
Does Knockout of GABRE in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | GABRE | cell proliferation | Glioblastoma Cell Line | Gene: GABRE (gamma-aminobutyric acid type A receptor subunit epsilon)
Type: protein-coding
Summary: The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fa... |
Does Knockout of EIF3C in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | EIF3C | cell proliferation | Hepatoma Cell Line | Gene: EIF3C (eukaryotic translation initiation factor 3 subunit C)
Type: protein-coding
Summary: Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initi... |
Does Knockout of INTS11 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | INTS11 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: INTS11 (integrator complex subunit 11)
Type: protein-coding
Summary: The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 18... |
Does Knockout of TINF2 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | TINF2 | cell proliferation | Bladder Carcinoma | Gene: TINF2 (TERF1 interacting nuclear factor 2)
Type: protein-coding
Summary: This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a crit... |
Does Knockout of USP39 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | USP39 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: USP39 (ubiquitin specific peptidase 39)
Type: protein-coding
Summary: Predicted to enable thiol-dependent deubiquitinase and zinc ion binding activity. Involved in spliceosomal complex assembly. Located in nucleoplasm. Part of U4/U6 x U5 tri-snRNP complex. [provided by Alliance of Genome Resources... |
Does Knockout of SETDB1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | SETDB1 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: SETDB1 (SET domain bifurcated histone lysine methyltransferase 1)
Type: protein-coding
Summary: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington D... |
Does Knockout of PKHD1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | PKHD1 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: PKHD1 (PKHD1 ciliary IPT domain containing fibrocystin/polyductin)
Type: protein-coding
Summary: The protein encoded by this gene is predicted to have a single transmembrane (TM)-spanning domain and multiple copies of an immunoglobulin-like plexin-transcription-factor domain. Alternative splicing ... |
Does Knockout of DLD in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | DLD | cell proliferation | Gastric Cancer Cell Line | Gene: DLD (dihydrolipoamide dehydrogenase)
Type: protein-coding
Summary: This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In... |
Does Knockout of ATF4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | ATF4 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ATF4 (activating transcription factor 4)
Type: protein-coding
Summary: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also is... |
Does Knockout of BRF1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | BRF1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: BRF1 (BRF1 general transcription factor IIIB subunit)
Type: protein-coding
Summary: This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRN... |
Does Knockout of FCF1 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | FCF1 | cell proliferation | Multiple Myeloma Cell Line | Gene: FCF1 (FCF1 rRNA-processing protein)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Predicted to act upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and endonucleolytic... |
Does Knockout of RSL1D1 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | RSL1D1 | cell proliferation | Astrocytoma Cell Line | Gene: RSL1D1 (ribosomal L1 domain containing 1)
Type: protein-coding
Summary: Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in regulation of apoptotic process and regulation of cellular senescence. Acts upstream of or within regulation of protein localization. Located i... |
Does Knockout of AGAP9 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | AGAP9 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: AGAP9 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 9)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in regulation of catalytic activity. Predicted to be active in nucleus. [provided by Alliance of Ge... |
Does Knockout of PAK3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 897 | Knockout | PAK3 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: PAK3 (p21 (RAC1) activated kinase 3)
Type: protein-coding
Summary: The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorg... |
Does Knockout of TNPO3 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | TNPO3 | cell proliferation | Colorectal Cancer Cell Line | Gene: TNPO3 (transportin 3)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through inter... |
Does Knockout of MIR193A in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | MIR193A | response to virus | Hepatoma Cell Line | Gene: MIR193A (microRNA 193a)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of NCAPG in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | NCAPG | cell proliferation | Gastric Cancer Cell Line | Gene: NCAPG (non-SMC condensin I complex subunit G)
Type: protein-coding
Summary: This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin co... |
Does Knockout of SPRYD3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | SPRYD3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SPRYD3 (SPRY domain containing 3)
Type: protein-coding
Summary: Predicted to be involved in cell surface receptor signaling pathway and cytoskeleton organization. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
... |
Does Knockout of RACGAP1 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | RACGAP1 | cell proliferation | Colorectal Cancer Cell Line | Gene: RACGAP1 (Rac GTPase activating protein 1)
Type: protein-coding
Summary: This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of R... |
Does Knockout of PSMB6 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | PSMB6 | cell proliferation | Bladder Carcinoma | Gene: PSMB6 (proteasome 20S subunit beta 6)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rin... |
Does Knockout of PSMD2 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | PSMD2 | cell proliferation | Gastric Cancer Cell Line | Gene: PSMD2 (proteasome 26S subunit ubiquitin receptor, non-ATPase 2)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical s... |
Does Knockout of ITIH2 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | ITIH2 | cell proliferation | Gastric Cancer Cell Line | Gene: ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2)
Type: protein-coding
Summary: The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family con... |
Does Activation of MIEF1 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | MIEF1 | response to virus | Hepatoma Cell Line | Gene: MIEF1 (mitochondrial elongation factor 1)
Type: protein-coding
Summary: Enables ADP binding activity; GDP binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of mitochondrial fission; positive regulation of mitochondrial translatio... |
Does Knockout of CDC123 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | CDC123 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: CDC123 (cell division cycle 123)
Type: protein-coding
Summary: Predicted to be involved in eukaryotic translation initiation factor 2 complex assembly and positive regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontol... |
Does Knockout of CCDC85C in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | CCDC85C | cell proliferation | Gastric Cancer Cell Line | Gene: CCDC85C (coiled-coil domain containing 85C)
Type: protein-coding
Summary: Predicted to be involved in cerebral cortex development. Located in adherens junction. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Notch signaling pathway, cell population proliferation, ... |
Does Knockout of ZNF572 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | ZNF572 | response to chemicals | Glioblastoma Cell Line | Gene: ZNF572 (zinc finger protein 572)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative reg... |
Does Knockout of ENY2 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | ENY2 | cell proliferation | Neuroblastoma Cell Line | Gene: ENY2 (ENY2 transcription and export complex 2 subunit)
Type: protein-coding
Summary: Enables nuclear receptor coactivator activity. Involved in histone deubiquitination; poly(A)+ mRNA export from nucleus; and positive regulation of transcription, DNA-templated. Located in mitochondrion and nucleop... |
Does Knockout of NUDT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | NUDT1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: NUDT1 (nudix hydrolase 1)
Type: protein-coding
Summary: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes ... |
Does Knockout of TRAPPC2 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | TRAPPC2 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: TRAPPC2 (trafficking protein particle complex subunit 2)
Type: protein-coding
Summary: The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. ... |
Does Knockout of NOP16 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | NOP16 | cell proliferation | Ovarian Cancer Cell Line | Gene: NOP16 (NOP16 nucleolar protein)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the nucleolus. Expression of this gene is induced by estrogens and Myc protein and is a marker of poor patient survival in breast cancer. Alternative splicing results in multiple transcri... |
Does Knockout of PM20D1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | PM20D1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: PM20D1 (peptidase M20 domain containing 1)
Type: protein-coding
Summary: Enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including amide biosynthetic process; cellular amide catabolic process; and negative regulation o... |
Does Knockout of CMBL in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | CMBL | cell proliferation | Colonic Cancer Cell Line | Gene: CMBL (carboxymethylenebutenolidase homolog)
Type: protein-coding
Summary: CMBL (EC 3.1.1.45) is a cysteine hydrolase of the dienelactone hydrolase family that is highly expressed in liver cytosol. CMBL preferentially cleaves cyclic esters, and it activates medoxomil-ester prodrugs in which the med... |
Does Knockout of ADK in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | ADK | cell proliferation | Prostate Cancer Cell Line | Gene: ADK (adenosine kinase)
Type: protein-coding
Summary: This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effec... |
Does Knockout of ZNF585B in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | ZNF585B | response to virus | Cervical Adenocarcinoma Cell Line | Gene: ZNF585B (zinc finger protein 585B)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription ... |
Does Knockout of UBE2L3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | UBE2L3 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: UBE2L3 (ubiquitin conjugating enzyme E2 L3)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating e... |
Does Knockout of NDC80 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | NDC80 | cell proliferation | Renal Cancer Cell Line | Gene: NDC80 (NDC80 kinetochore complex component)
Type: protein-coding
Summary: This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the compl... |
Does Knockout of FBXW11 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | FBXW11 | cell proliferation | Endometrial Cancer Cell Line | Gene: FBXW11 (F-box and WD repeat domain containing 11)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase compl... |
Does Knockout of LCMT1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | LCMT1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: LCMT1 (leucine carboxyl methyltransferase 1)
Type: protein-coding
Summary: LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by... |
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