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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of ANAPC1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
ANAPC1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ANAPC1 (anaphase promoting complex subunit 1)
Type: protein-coding
Summary: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, metaphase/anaphase transition of mitotic cell cycle, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; CC: anaphase-promoting complex, cytosol, nucleoplasm, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9H1A4
Entrez ID: 64682
|
Does Knockout of CKS1B in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
CKS1B
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CKS1B (CDC28 protein kinase regulatory subunit 1B)
Type: protein-coding
Summary: CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008].
Gene Ontology: BP: cell division, regulation of mitotic cell cycle; MF: cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase regulator activity, histone binding, protein binding, protein kinase binding, ubiquitin binding; CC: SCF ubiquitin ligase complex, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , FOXM1 transcription factor network, G1 Phase, G1/S Transition, Mitotic G1 phase and G1/S transition, Pathways in cancer - Homo sapiens (human), S Phase, SCF(Skp2)-mediated degradation of p27/p21, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), regulation of p27 phosphorylation during cell cycle progression
UniProt: P61024
Entrez ID: 1163
|
Does Knockout of DDX23 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
DDX23
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: DDX23 (DEAD-box helicase 23)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: R-loop processing, RNA splicing, RNA splicing, via transesterification reactions, cis assembly of pre-catalytic spliceosome, mRNA processing, mRNA splicing, via spliceosome; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding; CC: U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, chromatin, chromosome, extracellular exosome, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q9BUQ8
Entrez ID: 9416
|
Does Knockout of MORF4L1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
MORF4L1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: MORF4L1 (mortality factor 4 like 1)
Type: protein-coding
Summary: Enables protein N-terminus binding activity. Involved in double-strand break repair via homologous recombination and histone modification. Located in nuclear speck. Part of NuA4 histone acetyltransferase complex and Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cell population proliferation, chromatin organization, double-strand break repair via homologous recombination, fibroblast proliferation, positive regulation of DNA-templated transcription, positive regulation of double-strand break repair via homologous recombination, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle, regulation of double-strand break repair; MF: chromatin binding, protein binding; CC: NuA4 histone acetyltransferase complex, Sin3-type complex, nuclear speck, nucleoplasm, nucleosome, nucleus
Pathways: Pathways affected in adenoid cystic carcinoma
UniProt: Q9UBU8
Entrez ID: 10933
|
Does Knockout of DCTN6 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
DCTN6
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: DCTN6 (dynactin subunit 6)
Type: protein-coding
Summary: The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitotic spindle organization; MF: dynein complex binding; CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, dynactin complex, kinetochore, microtubule cytoskeleton
Pathways: Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cellular responses to stimuli, Cellular responses to stress, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Salmonella infection - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, lissencephaly gene (lis1) in neuronal migration and development
UniProt: O00399
Entrez ID: 10671
|
Does Knockout of COMMD6 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
COMMD6
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: COMMD6 (COMM domain containing 6)
Type: protein-coding
Summary: COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009].
Gene Ontology: BP: negative regulation of NF-kappaB transcription factor activity, signal transduction; MF: NF-kappaB binding, protein binding; CC: cytoplasm, nucleus
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q7Z4G1
Entrez ID: 170622
|
Does Knockout of DPH6 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
DPH6
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: DPH6 (diphthamine biosynthesis 6)
Type: protein-coding
Summary: Enables diphthine-ammonia ligase activity. Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein histidyl modification to diphthamide; MF: ATP binding, diphthine-ammonia ligase activity, ligase activity, nucleotide binding
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Synthesis of diphthamide-EEF2, diphthamide biosynthesis
UniProt: Q7L8W6
Entrez ID: 89978
|
Does Knockout of TLE3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
TLE3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TLE3 (TLE family member 3, transcriptional corepressor)
Type: protein-coding
Summary: This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: Wnt signaling pathway, animal organ morphogenesis, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, negative regulation of cold-induced thermogenesis, regulation of DNA-templated transcription, signal transduction; MF: protein binding, transcription corepressor activity; CC: beta-catenin-TCF complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Notch signaling pathway - Homo sapiens (human), White fat cell differentiation, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q04726
Entrez ID: 7090
|
Does Knockout of NUP133 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
NUP133
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NUP133 (nucleoporin 133)
Type: protein-coding
Summary: The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: animal organ development, mRNA export from nucleus, mRNA transport, nephron development, neural tube development, neurogenesis, nuclear pore organization, nucleocytoplasmic transport, paraxial mesoderm development, poly(A)+ mRNA export from nucleus, protein import into nucleus, protein transport, somite development, system development, transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; MF: protein binding, structural constituent of nuclear pore; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore outer ring, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, EML4 and NUDC in mitotic spindle formation, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q8WUM0
Entrez ID: 55746
|
Does Knockout of OR9G4 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
OR9G4
|
cell proliferation
|
Bladder Carcinoma
|
Gene: OR9G4 (olfactory receptor family 9 subfamily G member 4)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGQ1
Entrez ID: 283189
|
Does Knockout of PPIP5K2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
PPIP5K2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2)
Type: protein-coding
Summary: This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is thought to lack phosphatase activity. This kinase activity is the mechanism by which the encoded protein synthesizes high-energy inositol pyrophosphates, which act as signaling molecules that regulate cellular homeostasis and other processes. This gene may be associated with autism spectrum disorder in human patients. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: inositol metabolic process, inositol phosphate biosynthetic process, inositol phosphate metabolic process, sensory perception of sound; MF: 5-diphosphoinositol pentakisphosphate 1-kinase activity, ATP binding, diphosphoinositol pentakisphosphate kinase activity, inositol hexakisphosphate 1-kinase activity, inositol hexakisphosphate 5-kinase activity, inositol hexakisphosphate kinase activity, inositol-1,3,4,5,6-pentakisphosphate kinase activity, kinase activity, nucleotide binding, protein binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Phosphatidylinositol signaling system - Homo sapiens (human), inositol pyrophosphates biosynthesis, superpathway of inositol phosphate compounds
UniProt: O43314
Entrez ID: 23262
|
Does Knockout of REV1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
REV1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: REV1 (REV1 DNA directed polymerase)
Type: protein-coding
Summary: This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: DNA biosynthetic process, DNA damage response, DNA metabolic process, DNA repair, DNA replication, error-free translesion synthesis, error-prone translesion synthesis, response to UV; MF: DNA binding, DNA-directed DNA polymerase activity, damaged DNA binding, deoxycytidyl transferase activity, metal ion binding, nucleotidyltransferase activity, protein binding, transferase activity; CC: nucleoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Repair, DNA Repair Pathways Full Network, Fanconi anemia pathway - Homo sapiens (human), Termination of translesion DNA synthesis, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9UBZ9
Entrez ID: 51455
|
Does Knockout of LYG2 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
LYG2
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: LYG2 (lysozyme g2)
Type: protein-coding
Summary: The protein encoded by this gene contains a SLT domain, a protein domain present in bacterial lytic transglycosylase (SLT) and in eukaryotic lysozymes (GEWL). SLT domain catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyglucosamine (GlcNAc). [provided by RefSeq, Jul 2008].
Gene Ontology: BP: defense response to Gram-positive bacterium, defense response to bacterium, peptidoglycan catabolic process; MF: hydrolase activity, hydrolase activity, acting on glycosyl bonds, lysozyme activity, protein binding; CC: extracellular region
Pathways:
UniProt: Q86SG7
Entrez ID: 254773
|
Does Knockout of RPS13 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
RPS13
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: RPS13 (ribosomal protein S13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S15P family of ribosomal proteins. It is located in the cytoplasm. The protein has been shown to bind to the 5.8S rRNA in rat. The gene product of the E. coli ortholog (ribosomal protein S15) functions at early steps in ribosome assembly. This gene is co-transcribed with two U14 small nucleolar RNA genes, which are located in its third and fifth introns. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, negative regulation of RNA splicing, ribosomal small subunit biogenesis, translation; MF: RNA binding, mRNA 5'-UTR binding, mRNA binding, protein binding, small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome, small-subunit processome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, TNFalpha, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62277
Entrez ID: 6207
|
Does Knockout of ADAT2 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
ADAT2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ADAT2 (adenosine deaminase tRNA specific 2)
Type: protein-coding
Summary: Predicted to enable tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: tRNA processing, tRNA wobble adenosine to inosine editing; MF: catalytic activity, hydrolase activity, metal ion binding, protein binding, tRNA-specific adenosine deaminase activity, tRNA-specific adenosine-34 deaminase activity, zinc ion binding
Pathways: Metabolism of RNA, tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q7Z6V5
Entrez ID: 134637
|
Does Knockout of TACR2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
TACR2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: TACR2 (tachykinin receptor 2)
Type: protein-coding
Summary: This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, intestine smooth muscle contraction, muscle contraction, negative regulation of luteinizing hormone secretion, operant conditioning, positive regulation of acetylcholine secretion, neurotransmission, positive regulation of flagellated sperm motility, positive regulation of monoatomic ion transport, positive regulation of smooth muscle contraction, positive regulation of uterine smooth muscle contraction, positive regulation of vascular permeability, prolactin secretion, regulation of smooth muscle contraction, regulation of uterine smooth muscle contraction, response to electrical stimulus, signal transduction, tachykinin receptor signaling pathway; MF: G protein-coupled receptor activity, protein binding, substance K receptor activity, tachykinin receptor activity; CC: membrane, plasma membrane, sperm flagellum, sperm head, sperm midpiece
Pathways: Calcium signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide GPCRs, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Tachykinin receptors bind tachykinins
UniProt: P21452
Entrez ID: 6865
|
Does Knockout of DMBX1 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
DMBX1
|
response to virus
|
Huh-7 Cell
|
Gene: DMBX1 (diencephalon/mesencephalon homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adult feeding behavior, adult locomotory behavior, brain development, central nervous system development, developmental growth, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, identical protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus, transcription regulator complex
Pathways: Neural Crest Differentiation
UniProt: Q8NFW5
Entrez ID: 127343
|
Does Knockout of ZNF320 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
ZNF320
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: ZNF320 (zinc finger protein 320)
Type: protein-coding
Summary: ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription.[supplied by OMIM, Jul 2002].
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins
UniProt: A2RRD8
Entrez ID: 162967
|
Does Knockout of CIB3 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
CIB3
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: CIB3 (calcium and integrin binding family member 3)
Type: protein-coding
Summary: This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalytic subunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependent protein kinases. The exact function of this gene is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: MF: calcium ion binding, magnesium ion binding, metal ion binding, protein binding
Pathways:
UniProt: Q96Q77
Entrez ID: 117286
|
Does Knockout of MIEN1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
MIEN1
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: MIEN1 (migration and invasion enhancer 1)
Type: protein-coding
Summary: Involved in negative regulation of apoptotic process; positive regulation of cell migration; and positive regulation of filopodium assembly. Located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. Is intrinsic component of the cytoplasmic side of the plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, positive regulation of cell migration, positive regulation of filopodium assembly; CC: cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane, mitochondrion, plasma membrane
Pathways:
UniProt: Q9BRT3
Entrez ID: 84299
|
Does Knockout of N4BP2L2 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
N4BP2L2
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: N4BP2L2 (NEDD4 binding protein 2 like 2)
Type: protein-coding
Summary: Enables enzyme binding activity. Involved in negative regulation of hematopoietic stem cell differentiation and positive regulation of hematopoietic stem cell proliferation. Located in nucleus. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: blastocyst development, in utero embryonic development, negative regulation of hematopoietic stem cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of hematopoietic stem cell proliferation; MF: enzyme binding, protein binding, transcription corepressor activity; CC: extracellular exosome, nucleus, transcription repressor complex
Pathways:
UniProt: Q92802
Entrez ID: 10443
|
Does Knockout of HLA-A in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
HLA-A
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: HLA-A (major histocompatibility complex, class I, A)
Type: protein-coding
Summary: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. More than 6000 HLA-A alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020].
Gene Ontology: BP: CD8-positive, alpha-beta T cell activation, T cell mediated cytotoxicity, T cell mediated cytotoxicity directed against tumor cell target, T cell receptor signaling pathway, adaptive immune response, antibacterial humoral response, antigen processing and presentation, antigen processing and presentation of endogenous peptide antigen via MHC class I, antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent, antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent, antigen processing and presentation of endogenous peptide antigen via MHC class Ib, antigen processing and presentation of exogenous peptide antigen via MHC class I, antigen processing and presentation of peptide antigen via MHC class I, defense response to Gram-positive bacterium, detection of bacterium, immune response, immune system process, innate immune response, peptide antigen assembly with MHC class I protein complex, positive regulation of CD8-positive, alpha-beta T cell activation, positive regulation of CD8-positive, alpha-beta T cell proliferation, positive regulation of T cell cytokine production, positive regulation of T cell mediated cytotoxicity, positive regulation of memory T cell activation, positive regulation of type II interferon production, protection from natural killer cell mediated cytotoxicity; MF: CD8 receptor binding, RNA binding, T cell receptor binding, TAP binding, TAP complex binding, beta-2-microglobulin binding, peptide antigen binding, protein binding, signaling receptor binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi medial cisterna, Golgi membrane, MHC class I peptide loading complex, MHC class I protein complex, cell surface, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, external side of plasma membrane, extracellular exosome, extracellular space, lumenal side of endoplasmic reticulum membrane, membrane, phagocytic vesicle membrane, plasma membrane, recycling endosome membrane
Pathways: AP-1 transcription factor network, Adaptive Immune System, Allograft Rejection, Allograft rejection - Homo sapiens (human), Antigen Presentation: Folding, assembly and peptide loading of class I MHC, Antigen processing and presentation - Homo sapiens (human), Antigen processing-Cross presentation, Autoimmune thyroid disease - Homo sapiens (human), Cancer immunotherapy by PD-1 blockade, Cell adhesion molecules - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, Cytokine Signaling in Immune system, Disease, Downstream signaling in naïve CD8+ T cells, E3 ubiquitin ligases ubiquitinate target proteins, ER-Phagosome pathway, Ebola Virus Pathway on Host, Endocytosis - Homo sapiens (human), Endosomal/Vacuolar pathway, Epstein-Barr virus infection - Homo sapiens (human), Graft-versus-host disease - Homo sapiens (human), HIV Infection, Herpes simplex virus 1 infection - Homo sapiens (human), Host Interactions of HIV factors, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IL12-mediated signaling events, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Infectious disease, Interferon Signaling, Interferon alpha/beta signaling, Interferon gamma signaling, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Metabolism of proteins, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Nef mediated downregulation of MHC class I complex cell surface expression, Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, Phagosome - Homo sapiens (human), Post-translational protein modification, Proteasome Degradation, Protein ubiquitination, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, TCR signaling in naïve CD8+ T cells, The role of Nef in HIV-1 replication and disease pathogenesis, Type I diabetes mellitus - Homo sapiens (human), Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), Viral myocarditis - Homo sapiens (human), antigen processing and presentation, ras-independent pathway in nk cell-mediated cytotoxicity
UniProt: P04439
Entrez ID: 3105
|
Does Knockout of SH2D2A in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
SH2D2A
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: SH2D2A (SH2 domain containing 2A)
Type: protein-coding
Summary: This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: T cell proliferation, angiogenesis, cell differentiation, signal transduction; MF: SH3 domain binding, protein binding; CC: cytoplasm, cytosol
Pathways: EGF-EGFR signaling pathway, ErbB1 downstream signaling, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Signaling events mediated by VEGFR1 and VEGFR2, TCR, VEGF signaling pathway - Homo sapiens (human), VEGFA-VEGFR2 Pathway, VEGFA-VEGFR2 Signaling Pathway
UniProt: Q9NP31
Entrez ID: 9047
|
Does Knockout of EMC10 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
EMC10
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: EMC10 (ER membrane protein complex subunit 10)
Type: protein-coding
Summary: Contributes to membrane insertase activity. Involved in positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; and protein insertion into ER membrane. Located in extracellular region. Is integral component of endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: angiogenesis, positive regulation of angiogenesis, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, protein insertion into ER membrane by stop-transfer membrane-anchor sequence, tail-anchored membrane protein insertion into ER membrane; CC: EMC complex, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular region, membrane
Pathways: 22q11.2 copy number variation syndrome
UniProt: Q5UCC4
Entrez ID: 284361
|
Does Knockout of ZC3H15 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
ZC3H15
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: ZC3H15 (zinc finger CCCH-type containing 15)
Type: protein-coding
Summary: Enables RNA binding activity and cadherin binding activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytokine-mediated signaling pathway, cytoplasmic translation, positive regulation of GTPase activity; MF: RNA binding, cadherin binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol, nucleus
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Protein hydroxylation, VEGFA-VEGFR2 Signaling Pathway
UniProt: Q8WU90
Entrez ID: 55854
|
Does Knockout of KAT8 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
KAT8
|
cell proliferation
|
Cancer Cell Line
|
Gene: KAT8 (lysine acetyltransferase 8)
Type: protein-coding
Summary: This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: chromatin organization, dosage compensation by inactivation of X chromosome, epigenetic regulation of gene expression, epithelial to mesenchymal transition, hemopoiesis, membraneless organelle assembly, myeloid cell differentiation, negative regulation of DNA-templated transcription, negative regulation of epithelial to mesenchymal transition, negative regulation of macromolecule biosynthetic process, negative regulation of multicellular organismal process, negative regulation of type I interferon production, neurogenesis, oogenesis, positive regulation of DNA-templated transcription, positive regulation of epithelial to mesenchymal transition, positive regulation of skeletal muscle satellite cell differentiation, positive regulation of transcription initiation by RNA polymerase II, positive regulation of type I interferon production, post-embryonic hemopoiesis, regulation of DNA-templated transcription, regulation of autophagy, regulation of cell differentiation, regulation of mRNA processing, regulation of mitochondrial transcription, skeletal muscle satellite cell differentiation, transcription initiation-coupled chromatin remodeling; MF: DNA-binding transcription factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, acetyltransferase activity, acyltransferase activity, enzyme binding, histone H4 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone acetyltransferase activity, metal ion binding, promoter-specific chromatin binding, protein binding, protein propionyltransferase activity, protein-lysine-acetyltransferase activity, transcription coactivator activity, transferase activity, zinc ion binding; CC: MLL1 complex, MSL complex, NSL complex, NuA4 histone acetyltransferase complex, chromosome, histone acetyltransferase complex, kinetochore, mitochondrion, nuclear lumen, nuclear matrix, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones, p53 pathway
UniProt: Q9H7Z6
Entrez ID: 84148
|
Does Knockout of GRM8 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
GRM8
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: GRM8 (glutamate metabotropic receptor 8)
Type: protein-coding
Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled glutamate receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, regulation of synaptic transmission, glutamatergic, signal transduction, visual perception; MF: G protein-coupled receptor activity, glutamate receptor activity, group III metabotropic glutamate receptor activity; CC: membrane, plasma membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class C Metabotropic glutamate, pheromone, GPCRs, Other, Glutamatergic synapse - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: O00222
Entrez ID: 2918
|
Does Knockout of NUBP1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
NUBP1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: NUBP1 (NUBP iron-sulfur cluster assembly factor 1, cytosolic)
Type: protein-coding
Summary: NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell projection organization, centrosome localization, intracellular iron ion homeostasis, iron-sulfur cluster assembly, negative regulation of centrosome duplication, protein localization to cell cortex, regulation of cell growth; MF: 4 iron, 4 sulfur cluster binding, ATP binding, ATP-dependent FeS chaperone activity, iron-sulfur cluster binding, metal ion binding, nucleotide binding, protein binding; CC: Golgi apparatus, cell projection, centriole, centrosome, cilium, cytoplasm, cytoskeleton, cytosol, microtubule organizing center, nucleus
Pathways: Cytosolic iron-sulfur cluster assembly, Metabolism
UniProt: P53384
Entrez ID: 4682
|
Does Knockout of DCLRE1C in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
DCLRE1C
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: DCLRE1C (DNA cross-link repair 1C)
Type: protein-coding
Summary: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: B cell differentiation, DNA damage response, DNA metabolic process, DNA recombination, DNA repair, V(D)J recombination, adaptive immune response, chromosome organization, double-strand break repair, double-strand break repair via nonhomologous end joining, immune system process, interstrand cross-link repair, response to ionizing radiation, telomere maintenance; MF: 5'-3' DNA exonuclease activity, 5'-3' exonuclease activity, damaged DNA binding, endonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, protein binding, single-stranded DNA endodeoxyribonuclease activity; CC: Golgi apparatus, nonhomologous end joining complex, nucleoplasm, nucleus
Pathways: ATM Signaling Network in Development and Disease, ATM pathway, DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, DNA-PK pathway in nonhomologous end joining, Non-homologous end joining, Non-homologous end-joining - Homo sapiens (human), Nonhomologous End-Joining (NHEJ), Primary immunodeficiency - Homo sapiens (human)
UniProt: Q96SD1
Entrez ID: 64421
|
Does Knockout of SULT1E1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
SULT1E1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SULT1E1 (sulfotransferase family 1E member 1)
Type: protein-coding
Summary: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 3'-phosphoadenosine 5'-phosphosulfate metabolic process, estrogen catabolic process, estrogen metabolic process, ethanol catabolic process, lipid metabolic process, positive regulation of fat cell differentiation, steroid metabolic process, sulfation; MF: aryl sulfotransferase activity, estrone sulfotransferase activity, flavonol 3-sulfotransferase activity, lipid binding, protein binding, steroid binding, steroid sulfotransferase activity, sulfotransferase activity, transferase activity; CC: cytoplasm, cytosol, nuclear membrane
Pathways: 17-Beta Hydroxysteroid Dehydrogenase III Deficiency, Acetaminophen Metabolism Pathway, Androgen and Estrogen Metabolism, Aromatase deficiency, Biological oxidations, Cytosolic sulfonation of small molecules, Drug ADME, Estrogen metabolism, Metabolism, Metapathway biotransformation Phase I and II, Paracetamol ADME, Phase II - Conjugation of compounds, Photodynamic therapy-induced unfolded protein response, Steroid hormone biosynthesis - Homo sapiens (human), Sulfate/Sulfite Metabolism, Sulfation Biotransformation Reaction, Sulfite oxidase deficiency, Tamoxifen metabolism
UniProt: P49888
Entrez ID: 6783
|
Does Knockout of ABHD10 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
ABHD10
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: ABHD10 (abhydrolase domain containing 10, depalmitoylase)
Type: protein-coding
Summary: This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013].
Gene Ontology: BP: protein depalmitoylation, xenobiotic metabolic process; MF: hydrolase activity, hydrolase activity, hydrolyzing O-glycosyl compounds, mycophenolic acid acyl-glucuronide esterase activity, palmitoyl-(protein) hydrolase activity, protein binding; CC: cytosol, mitochondrial matrix, mitochondrion
Pathways: Biological oxidations, Glucuronidation, Metabolism, Phase II - Conjugation of compounds
UniProt: Q9NUJ1
Entrez ID: 55347
|
Does Knockout of RFC2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
RFC2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RFC2 (replication factor C subunit 2)
Type: protein-coding
Summary: This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: DNA repair, DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA clamp loader activity, enzyme binding, nucleotide binding, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, chromosome, nucleoplasm, nucleus
Pathways: ATR signaling pathway, DNA Mismatch Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), Fanconi anemia pathway, Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human)
UniProt: P35250
Entrez ID: 5982
|
Does Knockout of CNOT3 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
CNOT3
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CNOT3 (CCR4-NOT transcription complex subunit 3)
Type: protein-coding
Summary: Involved in regulation of stem cell population maintenance. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of cold-induced thermogenesis, regulation of DNA-templated transcription, regulation of stem cell population maintenance, regulation of translation, regulatory ncRNA-mediated gene silencing, trophectodermal cell differentiation; CC: CCR4-NOT complex, CCR4-NOT core complex, P-body, cytoplasm, cytosol, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Developmental Biology, Gene expression (Transcription), Generic Transcription Pathway, M-decay: degradation of maternal mRNAs by maternally stored factors, Maternal to zygotic transition (MZT), Metabolism of RNA, RNA Polymerase II Transcription, RNA degradation - Homo sapiens (human), TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: O75175
Entrez ID: 4849
|
Does Knockout of SAA4 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
SAA4
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: SAA4 (serum amyloid A4, constitutive)
Type: protein-coding
Summary: Predicted to be involved in acute-phase response. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular exosome, extracellular region, high-density lipoprotein particle
Pathways: Folate Metabolism, Selenium Micronutrient Network, Vitamin B12 metabolism
UniProt: P35542
Entrez ID: 6291
|
Does Knockout of TTI1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
TTI1
|
response to virus
|
Hepatoma Cell Line
|
Gene: TTI1 (TELO2 interacting protein 1)
Type: protein-coding
Summary: Involved in regulation of TOR signaling. Located in cytoplasm. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of DNA damage checkpoint, protein stabilization, regulation of TOR signaling; CC: TORC1 complex, TORC2 complex, TTT Hsp90 cochaperone complex, cytoplasm, nucleus
Pathways: Fragile X Syndrome, mTOR signaling pathway - Homo sapiens (human)
UniProt: O43156
Entrez ID: 9675
|
Does Knockout of MRPS9 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
MRPS9
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MRPS9 (mitochondrial ribosomal protein S9)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: intracellular organelle lumen, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, nucleolus, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: P82933
Entrez ID: 64965
|
Does Knockout of RPS28 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
RPS28
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPS28 (ribosomal protein S28)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S28E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maturation of SSU-rRNA, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic side of rough endoplasmic reticulum membrane, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, extracellular exosome, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62857
Entrez ID: 6234
|
Does Knockout of SUMO2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
SUMO2
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: SUMO2 (small ubiquitin like modifier 2)
Type: protein-coding
Summary: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of transcription by RNA polymerase II, protein sumoylation; MF: RNA binding, SUMO transferase activity, protein binding, protein tag activity, ubiquitin protein ligase binding, ubiquitin-like protein ligase binding; CC: GABA-ergic synapse, PML body, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, nucleoplasm, nucleus, postsynapse, postsynaptic cytosol, presynapse, presynaptic cytosol
Pathways: DNA Double-Strand Break Repair, DNA Repair, Epigenetic regulation of gene expression, Fluid shear stress and atherosclerosis - Homo sapiens (human), Formation of Incision Complex in GG-NER, Gene expression (Transcription), Global Genome Nucleotide Excision Repair (GG-NER), Glucocorticoid receptor regulatory network, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Metabolism, Metabolism of lipids, Metabolism of proteins, Metabolism of steroids, Nucleotide Excision Repair, Post-translational protein modification, Processing and activation of SUMO, Processing of DNA double-strand break ends, RNA transport - Homo sapiens (human), Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins, SUMO E3 ligases SUMOylate target proteins, SUMO is conjugated to E1 (UBA2:SAE1), SUMO is proteolytically processed, SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of intracellular receptors, SUMOylation of transcription cofactors, SUMOylation of transcription factors, Vitamin D (calciferol) metabolism, basic mechanisms of sumoylation
UniProt: P61956
Entrez ID: 6613
|
Does Knockout of RACK1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
RACK1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: RACK1 (receptor for activated C kinase 1)
Type: protein-coding
Summary: Enables several functions, including cyclin binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulation of cellular protein metabolic process; and regulation of signal transduction. Located in several cellular components, including midbody; perinuclear region of cytoplasm; and phagocytic cup. Part of IRE1-RACK1-PP2A complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, cellular response to glucose stimulus, cellular response to growth factor stimulus, cytoplasmic translation, gastrulation, negative regulation of Wnt signaling pathway, negative regulation of cell growth, negative regulation of endoplasmic reticulum unfolded protein response, negative regulation of gene expression, negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide, negative regulation of phagocytosis, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of protein binding, negative regulation of smoothened signaling pathway, negative regulation of translation, negative regulation of translational frameshifting, pigmentation, positive regulation of GTPase activity, positive regulation of Golgi to plasma membrane protein transport, positive regulation of apoptotic process, positive regulation of cell migration, positive regulation of gastrulation, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of mitochondrial depolarization, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein phosphorylation, positive regulation of protein-containing complex assembly, protein ubiquitination, regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of cell cycle, regulation of cell division, regulation of establishment of cell polarity, regulation of protein localization, regulation of translation, rescue of stalled ribosome, rhythmic process, translation; MF: BH3 domain binding, RNA binding, SH2 domain binding, cadherin binding, cyclin binding, cysteine-type endopeptidase activator activity involved in apoptotic process, enzyme activator activity, enzyme binding, identical protein binding, ion channel inhibitor activity, molecular adaptor activity, protein binding, protein homodimerization activity, protein kinase C binding, protein phosphatase binding, protein serine/threonine kinase inhibitor activity, protein tyrosine kinase inhibitor activity, receptor tyrosine kinase binding, ribosome binding, signaling adaptor activity, signaling receptor binding, translation regulator activity; CC: IRE1-RACK1-PP2A complex, cell body, cell projection, cytoplasm, cytosol, cytosolic small ribosomal subunit, dendrite, extracellular exosome, membrane, midbody, mitochondrion, neuron projection, neuronal cell body, nucleoplasm, nucleus, perikaryon, perinuclear region of cytoplasm, phagocytic cup, plasma membrane, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Adherens junctions interactions, Androgen receptor signaling pathway, AndrogenReceptor, Brain-derived neurotrophic factor (BDNF) signaling pathway, CXCR4-mediated signaling events, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Death Receptor Signaling, Degradation of CDH1, Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, IGF1 pathway, IL3, IL5, Interferon type I signaling pathways, Measles - Homo sapiens (human), Regulation of Androgen receptor activity, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of TNFR1 signaling, Signal Transduction, Syndecan-2-mediated signaling events, TNF receptor signaling pathway , TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR1-mediated ceramide production, TNFalpha, VEGFA-VEGFR2 Signaling Pathway, Validated transcriptional targets of deltaNp63 isoforms, p73 transcription factor network
UniProt: P63244
Entrez ID: 10399
|
Does Knockout of VPS8 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
VPS8
|
response to virus
|
Hepatoma Cell Line
|
Gene: VPS8 (VPS8 subunit of CORVET complex)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Involved in endosomal vesicle fusion. Located in early endosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endosomal vesicle fusion, protein targeting to vacuole, protein transport, regulation of SNARE complex assembly; MF: metal ion binding, protein binding, zinc ion binding; CC: CORVET complex, HOPS complex, early endosome, endosome, late endosome
Pathways:
UniProt: Q8N3P4
Entrez ID: 23355
|
Does Knockout of NCAPG2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
NCAPG2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NCAPG2 (non-SMC condensin II complex subunit G2)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: cell division, chromatin organization, chromosome condensation, erythrocyte differentiation, inner cell mass cell proliferation, mitotic sister chromatid segregation, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation, transcription by RNA polymerase II; MF: bHLH transcription factor binding, histone H4K20me1 reader activity, protein binding; CC: condensed nuclear chromosome, condensin complex, membrane, nuclear lumen, nuclear speck, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Condensation of Prophase Chromosomes, M Phase, Mesodermal commitment pathway, Mitotic Prophase
UniProt: Q86XI2
Entrez ID: 54892
|
Does Knockout of PLCB3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
PLCB3
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: PLCB3 (phospholipase C beta 3)
Type: protein-coding
Summary: This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled cAMP receptor signaling pathway, intracellular signal transduction, lipid catabolic process, lipid metabolic process, phosphatidylinositol metabolic process, phosphatidylinositol-mediated signaling, phospholipase C-activating G protein-coupled receptor signaling pathway, phospholipase C-activating serotonin receptor signaling pathway, regulation of systemic arterial blood pressure, release of sequestered calcium ion into cytosol, signal transduction; MF: cadherin binding, calcium ion binding, calmodulin binding, hydrolase activity, molecular adaptor activity, molecular function activator activity, phosphatidylinositol phospholipase C activity, phosphatidylinositol-4,5-bisphosphate phospholipase C activity, phospholipase C activity, phosphoric diester hydrolase activity, protein binding; CC: cytoplasm, cytosol, membrane, nucleus, postsynaptic cytosol, protein-containing complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), Acetylcholine regulates insulin secretion, Activation of kainate receptors upon glutamate binding, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), African trypanosomiasis - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amoebiasis - Homo sapiens (human), Apelin signaling pathway - Homo sapiens (human), Beta-catenin independent WNT signaling, CRH, CXCR4-mediated signaling events, Ca2+ pathway, Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Carbohydrate digestion and absorption - Homo sapiens (human), Chagas disease - Homo sapiens (human), Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, D-<i>myo</i>-inositol-5-phosphate metabolism, Diabetic cardiomyopathy - Homo sapiens (human), Dopaminergic synapse - Homo sapiens (human), Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), Endothelins, Estrogen signaling pathway - Homo sapiens (human), Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion, Free fatty acids regulate insulin secretion, G Protein Signaling Pathways, G alpha (i) signalling events, G alpha (q) signalling events, G beta:gamma signalling through PLC beta, G-protein beta:gamma signalling, G-protein mediated events, GPCR downstream signalling, GPR40 Pathway, Gap junction - Homo sapiens (human), Gastric acid secretion - Homo sapiens (human), Glucagon signaling pathway - Homo sapiens (human), Glutamatergic synapse - Homo sapiens (human), GnRH secretion - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), IL8- and CXCR1-mediated signaling events, IL8- and CXCR2-mediated signaling events, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Inositol phosphate metabolism, Inositol phosphate metabolism - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Integration of energy metabolism, Kisspeptin-kisspeptin receptor system in the ovary, LPA receptor mediated events, Lipid and atherosclerosis - Homo sapiens (human), Long-term depression - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), MAPK Cascade, Melanogenesis - Homo sapiens (human), Metabolism, Myometrial relaxation and contraction pathways, NOD-like receptor signaling pathway - Homo sapiens (human), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neutrophil extracellular trap formation - Homo sapiens (human), Non-genomic actions of 1,25 dihydroxyvitamin D3, Nongenotropic Androgen signaling, Opioid Signalling, Oxytocin signaling pathway - Homo sapiens (human), PAR1-mediated thrombin signaling events, PKC-gamma calcium signaling pathway in ataxia, PLC beta mediated events, Pancreatic secretion - Homo sapiens (human), Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Pathways Regulating Hippo Signaling, Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Plasma membrane estrogen receptor signaling, Platelet activation - Homo sapiens (human), Presynaptic function of Kainate receptors, Rap1 signaling pathway - Homo sapiens (human), Regulation of insulin secretion, Relaxin signaling pathway - Homo sapiens (human), Renin secretion - Homo sapiens (human), Resistin as a regulator of inflammation, Retrograde endocannabinoid signaling - Homo sapiens (human), Salivary secretion - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signal Transduction, Signal Transduction of S1P Receptor, Signaling by GPCR, Signaling by WNT, Sphingolipid signaling pathway - Homo sapiens (human), Spinocerebellar ataxia - Homo sapiens (human), Synthesis of IP3 and IP4 in the cytosol, Taste transduction - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid hormone synthesis - Homo sapiens (human), Transmission across Chemical Synapses, VEGFA-VEGFR2 Signaling Pathway, Vascular smooth muscle contraction - Homo sapiens (human), Wnt signaling, Wnt signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human), phospholipases, superpathway of inositol phosphate compounds
UniProt: Q01970
Entrez ID: 5331
|
Does Knockout of WDR75 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
WDR75
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: WDR75 (WD repeat domain 75)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding; CC: nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8IWA0
Entrez ID: 84128
|
Does Knockout of MED31 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
MED31
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: MED31 (mediator complex subunit 31)
Type: protein-coding
Summary: Predicted to enable transcription coregulator activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within limb development and negative regulation of fibroblast proliferation. Predicted to be located in nucleoplasm. Predicted to be part of core mediator complex and mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, limb development, negative regulation of fibroblast proliferation, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: protein binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9Y3C7
Entrez ID: 51003
|
Does Knockout of TCHP in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
TCHP
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TCHP (trichoplein keratin filament binding)
Type: protein-coding
Summary: Involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Located in several cellular components, including apical cortex; cytoskeleton; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, cell projection organization, negative regulation of cell growth, negative regulation of cilium assembly; CC: anchoring junction, apical cortex, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, desmosome, keratin filament, membrane, mitochondrion, nuclear membrane, plasma membrane, polymeric cytoskeletal fiber
Pathways:
UniProt: Q9BT92
Entrez ID: 84260
|
Does Knockout of IPO7 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
IPO7
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: IPO7 (importin 7)
Type: protein-coding
Summary: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: innate immune response, intracellular protein transport, negative regulation of cell cycle, negative regulation of osteoblast differentiation, positive regulation of odontoblast differentiation, positive regulation of protein localization to nucleus, protein import into nucleus, protein transport; MF: GTPase regulator activity, SMAD binding, histone binding, protein binding, small GTPase binding; CC: cytoplasm, cytosol, membrane, nuclear envelope, nuclear pore, nucleoplasm, nucleus
Pathways:
UniProt: O95373
Entrez ID: 10527
|
Does Knockout of LYZL2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
LYZL2
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: LYZL2 (lysozyme like 2)
Type: protein-coding
Summary: Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009].
Gene Ontology: MF: hydrolase activity, hydrolase activity, acting on glycosyl bonds, lysozyme activity
Pathways:
UniProt: Q7Z4W2
Entrez ID: 119180
|
Does Knockout of IFT20 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
IFT20
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: IFT20 (intraflagellar transport 20)
Type: protein-coding
Summary: This gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signalling components (Finetti et al., PubMed: 19855387). This gene is part of a complex set of sense-antisense loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14.[provided by RefSeq, Jun 2012].
Gene Ontology: BP: cardiac muscle cell differentiation, cell differentiation, cell projection organization, centrosome localization, cilium assembly, cochlea development, establishment of epithelial cell apical/basal polarity, establishment of planar polarity, inner ear receptor cell stereocilium organization, intraciliary anterograde transport, intraciliary transport, kidney development, neural precursor cell proliferation, neurogenesis, opsin transport, photoreceptor cell outer segment organization, positive regulation of cilium assembly, protein localization to Golgi apparatus, protein localization to cilium, protein localization to plasma membrane, protein transmembrane transport, regulation of autophagosome assembly, regulation of canonical Wnt signaling pathway, regulation of cilium assembly, regulation of platelet-derived growth factor receptor-alpha signaling pathway, smoothened signaling pathway, spermatogenesis, visual learning; MF: opsin binding, protein binding, small GTPase binding; CC: Golgi apparatus, Golgi membrane, acrosomal vesicle, cell projection, centriole, centrosome, ciliary basal body, ciliary base, ciliary tip, cilium, cis-Golgi network, cytoplasm, cytoplasmic vesicle, cytoskeleton, dendrite terminus, intraciliary transport particle, intraciliary transport particle B, kinociliary basal body, manchette, microvillus, motile cilium, neuron projection, non-motile cilium, photoreceptor connecting cilium, photoreceptor outer segment, stereocilium
Pathways: Ciliary landscape, Genes related to primary cilium development (based on CRISPR)
UniProt: Q8IY31
Entrez ID: 90410
|
Does Knockout of GNAI3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
GNAI3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: GNAI3 (G protein subunit alpha i3)
Type: protein-coding
Summary: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, GTP metabolic process, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell division, negative regulation of adenylate cyclase activity, positive regulation of macroautophagy, signal transduction; MF: G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, GDP binding, GTP binding, GTPase activity, guanyl nucleotide binding, metal ion binding, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi membrane, centriolar satellite, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum membrane, extracellular exosome, heterotrimeric G-protein complex, lysosomal membrane, membrane, midbody, nucleolus, nucleoplasm, plasma membrane
Pathways: ADORA2B mediated anti-inflammatory cytokines production, ADP signalling through P2Y purinoceptor 12, Activation of GABAB receptors, Adenylate cyclase inhibitory pathway, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alcoholism - Homo sapiens (human), Anti-inflammatory response favouring Leishmania parasite infection, Apelin signaling pathway - Homo sapiens (human), Axon guidance - Homo sapiens (human), CXCR3-mediated signaling events, CXCR4-mediated signaling events, Calcium Regulation in the Cardiac Cell, Chagas disease - Homo sapiens (human), Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Cocaine addiction - Homo sapiens (human), Complement system, Cushing syndrome - Homo sapiens (human), Disease, Dopaminergic synapse - Homo sapiens (human), ESR-mediated signaling, Endothelins, Estrogen signaling pathway - Homo sapiens (human), Extra-nuclear estrogen signaling, G Protein Signaling Pathways, G alpha (i) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G-protein mediated events, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Homo sapiens (human), GPCR downstream signalling, GPER1 signaling, Gap junction - Homo sapiens (human), Gastric acid secretion - Homo sapiens (human), Glutamatergic synapse - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hedgehog signaling events mediated by Gli proteins, Hemostasis, Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Infectious disease, LPA receptor mediated events, Leishmania infection, Leishmania parasite growth and survival, Leukocyte transendothelial migration - Homo sapiens (human), Long-term depression - Homo sapiens (human), Melanogenesis - Homo sapiens (human), Morphine addiction - Homo sapiens (human), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nongenotropic Androgen signaling, Opioid Signalling, Oxytocin signaling pathway - Homo sapiens (human), PAR1-mediated thrombin signaling events, Parasitic Infection Pathways, Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways Regulating Hippo Signaling, Pathways in cancer - Homo sapiens (human), Pertussis - Homo sapiens (human), Plasma membrane estrogen receptor signaling, Platelet activation - Homo sapiens (human), Platelet activation, signaling and aggregation, Progesterone-mediated oocyte maturation - Homo sapiens (human), Purinergic signaling, Rap1 signaling pathway - Homo sapiens (human), Regulation of lipolysis in adipocytes - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Renin secretion - Homo sapiens (human), Retrograde endocannabinoid signaling - Homo sapiens (human), S1P1 pathway, S1P2 pathway, S1P3 pathway, S1P4 pathway, S1P5 pathway, SHP2 signaling, Serotonergic synapse - Homo sapiens (human), Signal Transduction, Signal Transduction of S1P Receptor, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Sphingolipid signaling pathway - Homo sapiens (human), Sphingosine 1-phosphate (S1P) pathway, TSH, Thyroid stimulating hormone (TSH) signaling pathway, Toxoplasmosis - Homo sapiens (human), Transmission across Chemical Synapses, cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P08754
Entrez ID: 2773
|
Does Knockout of ZMAT5 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
ZMAT5
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: ZMAT5 (zinc finger matrin-type 5)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in RNA splicing. Located in nucleoplasm. Part of U12-type spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing; MF: metal ion binding, protein binding, zinc ion binding; CC: U12-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Minor Pathway
UniProt: Q9UDW3
Entrez ID: 55954
|
Does Knockout of LRRC27 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
LRRC27
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: LRRC27 (leucine rich repeat containing 27)
Type: protein-coding
Summary: leucine rich repeat containing 27
Gene Ontology:
Pathways:
UniProt: Q9C0I9
Entrez ID: 80313
|
Does Knockout of GRAP2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
GRAP2
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: GRAP2 (GRB2 related adaptor protein 2)
Type: protein-coding
Summary: This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: Ras protein signal transduction, cell-cell signaling, regulation of MAPK cascade, signal transduction; MF: phosphotyrosine residue binding, protein binding; CC: cytoplasm, cytosol, endosome, nucleoplasm, nucleus, plasma membrane
Pathways: Adaptive Immune System, Co-stimulation by CD28, Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, FCERI mediated Ca+2 mobilization, FCERI mediated MAPK activation, FLT3 Signaling, Fc epsilon receptor (FCERI) signaling, Generation of second messenger molecules, Immune System, Innate Immune System, JNK signaling in the CD4+ TCR pathway, Modulators of TCR signaling and T cell activation, Regulation of T cell activation by CD28 family, Signal Transduction, Signaling by CSF1 (M-CSF) in myeloid cells, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling events mediated by Stem cell factor receptor (c-Kit), T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, T-cell receptor (TCR) signaling pathway, TCR, TCR signaling, TCR signaling in naïve CD4+ T cells, TCR signaling in naïve CD8+ T cells
UniProt: O75791
Entrez ID: 9402
|
Does Knockout of SLC6A18 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
SLC6A18
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: SLC6A18 (solute carrier family 6 member 18)
Type: protein-coding
Summary: The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Apr 2010].
Gene Ontology: BP: amino acid transmembrane transport, amino acid transport, neurotransmitter transport, renal amino acid absorption, sodium ion transmembrane transport; MF: amino acid transmembrane transporter activity, symporter activity, transmembrane transporter activity; CC: apical plasma membrane, brush border membrane, membrane, plasma membrane
Pathways: NRF2 pathway, Nuclear Receptors Meta-Pathway, Proximal tubule transport
UniProt: Q96N87
Entrez ID: 348932
|
Does Knockout of ZNF559 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
ZNF559
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ZNF559 (zinc finger protein 559)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9BR84
Entrez ID: 84527
|
Does Knockout of EXT1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
EXT1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: EXT1 (exostosin glycosyltransferase 1)
Type: protein-coding
Summary: This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: BMP signaling pathway, antigen processing and presentation, axon guidance, basement membrane organization, blood vessel remodeling, bone growth, bone morphogenesis, bone resorption, brain development, canonical Wnt signaling pathway, cartilage development involved in endochondral bone morphogenesis, cell adhesion, cell adhesion mediated by integrin, cell fate commitment, cell morphogenesis, cell population proliferation, cell surface receptor signaling pathway, cellular response to BMP stimulus, cellular response to fibroblast growth factor stimulus, cellular response to virus, chondrocyte differentiation, chondrocyte hypertrophy, chondrocyte proliferation, chondroitin sulfate proteoglycan metabolic process, collagen fibril organization, cranial skeletal system development, dendrite self-avoidance, dendritic cell migration, developmental growth involved in morphogenesis, embryonic morphogenesis, embryonic skeletal joint development, endochondral bone growth, endochondral bone morphogenesis, endochondral ossification, endoderm development, epithelial tube branching involved in lung morphogenesis, epithelium development, fear response, fibroblast growth factor receptor signaling pathway, fluid transport, gastrulation, gene expression, glandular epithelial cell differentiation, glomerular basement membrane development, glycosaminoglycan biosynthetic process, hair cycle process, hair follicle morphogenesis, heart contraction, heart field specification, hematopoietic progenitor cell differentiation, hematopoietic stem cell differentiation, hematopoietic stem cell homeostasis, hematopoietic stem cell migration to bone marrow, heparan sulfate proteoglycan biosynthetic process, heparin proteoglycan biosynthetic process, heparin proteoglycan metabolic process, hypersensitivity, leukocyte tethering or rolling, limb joint morphogenesis, lymphocyte adhesion to endothelial cell of high endothelial venule, lymphocyte migration into lymphoid organs, mesenchymal cell differentiation involved in bone development, mesenchyme development, mesoderm development, motor behavior, multicellular organism growth, multicellular organismal-level water homeostasis, neural crest cell differentiation, neuron projection development, olfactory bulb development, optic nerve development, ossification, ossification involved in bone maturation, perichondral bone morphogenesis, podocyte differentiation, polysaccharide biosynthetic process, protein catabolic process, protein glycosylation, protein-containing complex assembly, proteoglycan biosynthetic process, regulation of blood pressure, regulation of tumor necrosis factor-mediated signaling pathway, response to growth factor, response to heparin, response to leukemia inhibitory factor, response to light intensity, response to virus, sebaceous gland development, smoothened signaling pathway, smoothened signaling pathway involved in lung development, social behavior, sodium ion homeostasis, stem cell division, stomach development, sulfation, sweat gland development, synaptic transmission, glutamatergic, tight junction organization, vacuole organization, vasodilation, vocalization behavior, wound healing; MF: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity, acetylglucosaminyltransferase activity, glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity, glucuronosyltransferase activity, glycosyltransferase activity, heparan sulfate N-acetylglucosaminyltransferase activity, metal ion binding, protein binding, protein heterodimerization activity, protein homodimerization activity, transferase activity; CC: Golgi apparatus, Golgi membrane, catalytic complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, organelle membrane, synapse
Pathways: Defective EXT1 causes exostoses 1, TRPS2 and CHDS, Defective EXT2 causes exostoses 2, Disease, Diseases associated with glycosaminoglycan metabolism, Diseases of glycosylation, Diseases of metabolism, Endoderm differentiation, Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human), Glycosaminoglycan metabolism, HS-GAG biosynthesis, Heparan sulfate/heparin (HS-GAG) metabolism, Mesodermal commitment pathway, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Proteoglycan biosynthesis, heparan sulfate biosynthesis, heparan sulfate biosynthesis (late stages)
UniProt: Q16394
Entrez ID: 2131
|
Does Knockout of ACTR3 in Glioma Cell Line causally result in protein/peptide accumulation?
| 1
| 589
|
Knockout
|
ACTR3
|
protein/peptide accumulation
|
Glioma Cell Line
|
Gene: ACTR3 (actin related protein 3)
Type: protein-coding
Summary: The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013].
Gene Ontology: BP: Arp2/3 complex-mediated actin nucleation, actin polymerization-dependent cell motility, asymmetric cell division, cell projection organization, cellular response to type II interferon, cilium assembly, establishment or maintenance of cell polarity, meiotic cell cycle, meiotic chromosome movement towards spindle pole, meiotic cytokinesis, positive regulation of lamellipodium assembly, positive regulation of transcription by RNA polymerase II, spindle localization; MF: ATP binding, actin binding, actin filament binding, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: Arp2/3 protein complex, actin cytoskeleton, brush border, cell projection, cell-cell junction, cytoplasm, cytoskeleton, cytosol, extracellular exosome, focal adhesion, lamellipodium, membrane, nucleus, site of double-strand break
Pathways: Association Between Physico-Chemical Features and Toxicity Associated Pathways, Axon guidance, Bacterial invasion of epithelial cells - Homo sapiens (human), CDC42 signaling events, Clathrin-mediated endocytosis, Developmental Biology, Disease, EGFR1, EPH-Ephrin signaling, EPHB-mediated forward signaling, Endocytosis - Homo sapiens (human), ErbB1 downstream signaling, FCGR3A-mediated phagocytosis, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania phagocytosis, Membrane Trafficking, Nervous system development, PDGFR-beta signaling pathway, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), RAC1 signaling pathway, RHO GTPase Effectors, RHO GTPases Activate WASPs and WAVEs, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Tight junction - Homo sapiens (human), Vesicle-mediated transport, Yersinia infection - Homo sapiens (human), how does salmonella hijack a cell, role of pi3k subunit p85 in regulation of actin organization and cell migration, y branching of actin filaments
UniProt: P61158
Entrez ID: 10096
|
Does Knockout of MCM7 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
MCM7
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: MCM7 (minichromosome maintenance complex component 7)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA replication, DNA replication initiation, DNA strand elongation involved in DNA replication, cell population proliferation, cellular response to epidermal growth factor stimulus, cellular response to xenobiotic stimulus, double-strand break repair via break-induced replication, regulation of DNA-templated DNA replication initiation, regulation of phosphorylation, response to xenobiotic stimulus; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: CMG complex, MCM complex, chromatin, chromosome, chromosome, telomeric region, membrane, nucleolus, nucleoplasm, nucleus
Pathways: ATR signaling pathway, Cell cycle, Cell cycle - Homo sapiens (human), Ciliary landscape, DNA Replication, DNA replication - Homo sapiens (human), G1 to S cell cycle control, Retinoblastoma gene in cancer, TNFalpha, cdk regulation of dna replication, miRNA regulation of DNA damage response
UniProt: P33993
Entrez ID: 4176
|
Does Knockout of ATP2B2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
ATP2B2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: ATP2B2 (ATPase plasma membrane Ca2+ transporting 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, neuron differentiation, regulation of cardiac conduction, regulation of cytosolic calcium ion concentration, regulation of postsynaptic cytosolic calcium ion concentration, sensory perception of sound; MF: ATP binding, ATP hydrolysis activity, P-type calcium transporter activity, P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration, PDZ domain binding, calcium ion binding, calmodulin binding, metal ion binding, nucleotide binding, protein binding; CC: GABA-ergic synapse, apical plasma membrane, basolateral plasma membrane, cytoplasm, dendritic spine membrane, extracellular exosome, glutamatergic synapse, intracellular membrane-bounded organelle, membrane, plasma membrane, postsynaptic density membrane, synapse
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), Mineral absorption - Homo sapiens (human), PKC-gamma calcium signaling pathway in ataxia, Pancreatic secretion - Homo sapiens (human), Salivary secretion - Homo sapiens (human), Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea, Vitamin D-sensitive calcium signaling in depression, cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: Q01814
Entrez ID: 491
|
Does Activation of TLX3 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
TLX3
|
response to virus
|
Hepatoma Cell Line
|
Gene: TLX3 (T cell leukemia homeobox 3)
Type: protein-coding
Summary: The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: GABAergic neuron differentiation, animal organ development, central nervous system development, negative regulation of neuron differentiation, neuron differentiation, neuron fate specification, neuron migration, regulation of DNA-templated transcription, regulation of respiratory gaseous exchange by nervous system process, regulation of transcription by RNA polymerase II, respiratory gaseous exchange by respiratory system; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Cell Differentiation - Index, Cell Differentiation - Index expanded, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: O43711
Entrez ID: 30012
|
Does Knockout of ZKSCAN2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
ZKSCAN2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ZKSCAN2 (zinc finger with KRAB and SCAN domains 2)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, sequence-specific DNA binding, zinc ion binding
Pathways:
UniProt: Q63HK3
Entrez ID: 342357
|
Does Knockout of USPL1 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
USPL1
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: USPL1 (ubiquitin specific peptidase like 1)
Type: protein-coding
Summary: Enables SUMO binding activity and SUMO-specific isopeptidase activity. Involved in several processes, including Cajal body organization; protein desumoylation; and snRNA transcription. Located in Cajal body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Cajal body organization, cell population proliferation, protein desumoylation, proteolysis, snRNA transcription; MF: SUMO binding, cysteine-type peptidase activity, deSUMOylase activity, hydrolase activity, peptidase activity, protein binding, ubiquitin binding; CC: Cajal body, extracellular space, nucleus
Pathways:
UniProt: Q5W0Q7
Entrez ID: 10208
|
Does Knockout of PRPF38A in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
PRPF38A
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: PRPF38A (pre-mRNA processing factor 38A)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: U2-type precatalytic spliceosome, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: MECP2 and Associated Rett Syndrome, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8NAV1
Entrez ID: 84950
|
Does Knockout of NUS1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
NUS1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit)
Type: protein-coding
Summary: This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017].
Gene Ontology: BP: angiogenesis, cell differentiation, cholesterol homeostasis, dolichyl diphosphate biosynthetic process, dolichyl monophosphate biosynthetic process, lipid metabolic process, positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis, positive regulation of cell migration involved in sprouting angiogenesis, protein glycosylation, regulation of intracellular cholesterol transport, sterol homeostasis, vascular endothelial growth factor signaling pathway; MF: ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity, metal ion binding, prenyltransferase activity, protein binding, transferase activity, transferase activity, transferring alkyl or aryl (other than methyl) groups; CC: dehydrodolichyl diphosphate synthase complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective DHDDS causes RP59, Disease, Diseases associated with glycosylation precursor biosynthesis, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, Post-translational protein modification, Synthesis of dolichyl-phosphate, Synthesis of substrates in N-glycan biosythesis, Terpenoid backbone biosynthesis - Homo sapiens (human)
UniProt: Q96E22
Entrez ID: 116150
|
Does Knockout of GPS1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
GPS1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: GPS1 (G protein pathway suppressor 1)
Type: protein-coding
Summary: This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: JNK cascade, protein deneddylation, protein neddylation, regulation of protein neddylation; MF: GTPase inhibitor activity, protein binding; CC: COP9 signalosome, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Post-translational protein modification, RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q13098
Entrez ID: 2873
|
Does Knockout of MTG2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
MTG2
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: MTG2 (mitochondrial ribosome associated GTPase 2)
Type: protein-coding
Summary: Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: mitochondrial large ribosomal subunit assembly, regulation of mitochondrial translation, regulation of respiratory system process, regulation of translation, ribosome biogenesis; MF: GTP binding, GTPase activity, magnesium ion binding, metal ion binding, nucleotide binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrion
Pathways:
UniProt: Q9H4K7
Entrez ID: 26164
|
Does Knockout of NMT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
NMT1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: NMT1 (N-myristoyltransferase 1)
Type: protein-coding
Summary: Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008].
Gene Ontology: BP: N-terminal peptidyl-glycine N-myristoylation, cellular response to nutrient levels, in utero embryonic development, ketone metabolic process, positive regulation of TORC1 signaling, positive regulation of establishment of protein localization to mitochondrion, positive regulation of protein localization to lysosome, protein localization to membrane, regulation of opsin-mediated signaling pathway; MF: acyltransferase activity, glycylpeptide N-tetradecanoyltransferase activity, myristoyltransferase activity, peptidyl-lysine N6-myristoyltransferase activity, protein binding, transferase activity; CC: cytoplasm, cytosol, membrane, plasma membrane
Pathways:
UniProt: P30419
Entrez ID: 4836
|
Does Knockout of PYROXD1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
PYROXD1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1)
Type: protein-coding
Summary: This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other proteins. The encoded protein belongs to the class I pyridine nucleotide-disulphide oxidoreductase family but lacks the C-terminal dimerization domain found in other family members and instead has a C-terminal nitrile reductase domain. It localizes to the nucleus and to striated sarcomeric compartments. Naturally occurring mutations in this gene cause early-onset myopathy with internalized nuclei and myofibrillar disorganization. A pseudogene of this gene has been defined on chromosome 11. [provided by RefSeq, Apr 2017].
Gene Ontology: MF: NAD(P)H oxidase H2O2-forming activity, oxidoreductase activity, protein binding; CC: cytoplasm, nucleus, sarcomere
Pathways:
UniProt: Q8WU10
Entrez ID: 79912
|
Does Knockout of SF3B6 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
SF3B6
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SF3B6 (splicing factor 3b subunit 6)
Type: protein-coding
Summary: This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, blastocyst formation, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding; CC: U12-type spliceosomal complex, U2 snRNP, U2-type spliceosomal complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q9Y3B4
Entrez ID: 51639
|
Does Knockout of ALDH2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
ALDH2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: ALDH2 (aldehyde dehydrogenase 2 family member)
Type: protein-coding
Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016].
Gene Ontology: BP: alcohol metabolic process, aldehyde catabolic process, carbohydrate metabolic process, cellular detoxification of aldehyde, ethanol catabolic process, ethanol metabolic process, nitroglycerin metabolic process, regulation of dopamine biosynthetic process, regulation of serotonin biosynthetic process; MF: NAD binding, aldehyde dehydrogenase (NAD+) activity, aldehyde dehydrogenase [NAD(P)+] activity, carboxylesterase activity, electron transfer activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, phenylacetaldehyde dehydrogenase (NAD+) activity; CC: extracellular exosome, mitochondrial matrix, mitochondrion
Pathways: 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency, 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency, 3-Methylcrotonyl Coa Carboxylase Deficiency Type I, 3-Methylglutaconic Aciduria Type I, 3-Methylglutaconic Aciduria Type III, 3-Methylglutaconic Aciduria Type IV, 3-Phosphoglycerate dehydrogenase deficiency, 3-hydroxyisobutyric acid dehydrogenase deficiency, 3-hydroxyisobutyric aciduria, Arginine and proline metabolism - Homo sapiens (human), Ascorbate and aldarate metabolism - Homo sapiens (human), Beta-Alanine Metabolism, Beta-Ketothiolase Deficiency, Biological oxidations, Carnosinuria, carnosinemia, Dihydropyrimidine Dehydrogenase Deficiency (DHPD), Dimethylglycine Dehydrogenase Deficiency, Disulfiram Action Pathway, Ethanol Degradation, Ethanol effects on histone modifications, Ethanol oxidation, Fatty Acid Omega Oxidation, Fatty acid degradation - Homo sapiens (human), Fluoroacetic acid toxicity, GABA-Transaminase Deficiency, Glycerolipid metabolism - Homo sapiens (human), Glycine and Serine Metabolism, Glycolysis / Gluconeogenesis - Homo sapiens (human), Histidine Metabolism, Histidine metabolism - Homo sapiens (human), Histidinemia, Hyperglycinemia, non-ketotic, Isobutyryl-coa dehydrogenase deficiency, Isovaleric Aciduria, Isovaleric acidemia, Leigh Syndrome, Lysine degradation - Homo sapiens (human), Maple Syrup Urine Disease, Metabolism, Metabolism of proteins, Metabolism of serotonin, Methylmalonate Semialdehyde Dehydrogenase Deficiency, Methylmalonic Aciduria, Mitochondrial protein degradation, Muscle contraction, Neuronal System, Neurotransmitter clearance, Non Ketotic Hyperglycinemia, Oxidation of Branched Chain Fatty Acids, Pantothenate and CoA biosynthesis - Homo sapiens (human), Phase I - Functionalization of compounds, Primary hyperoxaluria II, PH2, Propionic Acidemia, Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency), Pyruvate Dehydrogenase Complex Deficiency, Pyruvate Metabolism, Pyruvate kinase deficiency, Pyruvate metabolism - Homo sapiens (human), Sarcosinemia, Serotonin clearance from the synaptic cleft, Smooth Muscle Contraction, Transmission across Chemical Synapses, Tryptophan Metabolism, Tryptophan metabolism, Tryptophan metabolism - Homo sapiens (human), Ureidopropionase deficiency, Valine, Leucine and Isoleucine Degradation, Valine, leucine and isoleucine degradation - Homo sapiens (human), beta-Alanine metabolism - Homo sapiens (human), ethanol degradation II, ethanol degradation IV, noradrenaline and adrenaline degradation, oxidative ethanol degradation III, phenylethylamine degradation I, putrescine degradation III, serotonin degradation, superpathway of tryptophan utilization
UniProt: P05091
Entrez ID: 217
|
Does Knockout of MAP1LC3B2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
MAP1LC3B2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in autophagy of mitochondrion; cellular response to nitrogen starvation; and macroautophagy. Located in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: autophagosome assembly, autophagosome maturation, autophagy, autophagy of mitochondrion, cellular response to nitrogen starvation, mitophagy; MF: microtubule binding, phosphatidylethanolamine binding, phospholipid binding, ubiquitin protein ligase binding; CC: autophagosome, autophagosome membrane, cytoplasm, cytoplasmic vesicle, cytoskeleton, endomembrane system, membrane, microtubule
Pathways: Ferroptosis - Homo sapiens (human)
UniProt: A6NCE7
Entrez ID: 643246
|
Does Knockout of ZBBX in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
ZBBX
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ZBBX (zinc finger B-box domain containing)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in cilium movement. Predicted to be active in motile cilium. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, zinc ion binding
Pathways:
UniProt: A8MT70
Entrez ID: 79740
|
Does Knockout of ZBTB11 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
ZBTB11
|
cell proliferation
|
Bladder Carcinoma
|
Gene: ZBTB11 (zinc finger and BTB domain containing 11)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Located in nucleoplasm. Implicated in autosomal recessive non-syndromic intellectual disability. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: O95625
Entrez ID: 27107
|
Does Knockout of SNIP1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
SNIP1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SNIP1 (Smad nuclear interacting protein 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012].
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, miRNA processing, negative regulation of canonical NF-kappaB signal transduction, regulation of gene expression, regulatory ncRNA-mediated gene silencing; MF: RNA binding, mRNA binding, protein binding, transcription regulator inhibitor activity; CC: U2 snRNP, U2-type precatalytic spliceosome, cytosol, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Regulation of nuclear SMAD2/3 signaling, TGF-beta Signaling Pathway, TGF_beta_Receptor, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8TAD8
Entrez ID: 79753
|
Does Knockout of MCM3 in Prostate Cancer Cell Line causally result in response to chemicals?
| 1
| 2,109
|
Knockout
|
MCM3
|
response to chemicals
|
Prostate Cancer Cell Line
|
Gene: MCM3 (minichromosome maintenance complex component 3)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018].
Gene Ontology: BP: DNA replication, DNA replication initiation, DNA strand elongation involved in DNA replication, double-strand break repair via break-induced replication, mitotic DNA replication initiation, regulation of DNA-templated DNA replication initiation; MF: ATP binding, ATP hydrolysis activity, DNA binding, helicase activity, hydrolase activity, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: CMG complex, MCM complex, alpha DNA polymerase:primase complex, chromosome, chromosome, telomeric region, cytoplasm, membrane, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Ciliary landscape, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA strand elongation, E2F transcription factor network, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, Retinoblastoma gene in cancer, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, Unwinding of DNA, cdk regulation of dna replication
UniProt: P25205
Entrez ID: 4172
|
Does Knockout of UBE2V1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
UBE2V1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: UBE2V1 (ubiquitin conjugating enzyme E2 V1)
Type: protein-coding
Summary: Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: cell differentiation, error-free postreplication DNA repair, positive regulation of DNA-templated transcription, positive regulation of canonical NF-kappaB signal transduction, positive regulation of intracellular signal transduction, positive regulation of protein K63-linked ubiquitination, postreplication repair, protein K63-linked ubiquitination, protein polyubiquitination, regulation of DNA repair, regulation of DNA-templated transcription; MF: protein binding, ubiquitin conjugating enzyme activity, ubiquitin conjugating enzyme binding; CC: UBC13-MMS2 complex, cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, protein-containing complex, ubiquitin conjugating enzyme complex, ubiquitin ligase complex
Pathways: IL-1 signaling pathway, IL1, IL1-mediated signaling events, Interleukin-1 Induced Activation of NF-kappa-B, Shigellosis - Homo sapiens (human), Simplified Depiction of MYD88 Distinct Input-Output Pathway
UniProt: Q13404
Entrez ID: 7335
|
Does Knockout of AAMP in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
AAMP
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: AAMP (angio associated migratory cell protein)
Type: protein-coding
Summary: The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: angiogenesis, cell differentiation, positive regulation of endothelial cell migration, smooth muscle cell migration; MF: heparin binding, protein binding; CC: cell surface, cytoplasm, cytosol, intercellular bridge, membrane, microtubule cytoskeleton, plasma membrane
Pathways: Hemostasis, Immune System, Innate Immune System, NOD1/2 Signaling Pathway, Nucleotide-binding Oligomerization Domain (NOD) pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Platelet activation, signaling and aggregation, Signal Transduction, Signal amplification, Signaling by EGFR, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Thromboxane signalling through TP receptor
UniProt: Q13685
Entrez ID: 14
|
Does Knockout of ZNF491 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
ZNF491
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ZNF491 (zinc finger protein 491)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8N8L2
Entrez ID: 126069
|
Does Knockout of SERTAD2 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
SERTAD2
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: SERTAD2 (SERTA domain containing 2)
Type: protein-coding
Summary: Predicted to enable transcription coactivator activity. Acts upstream of or within negative regulation of cell growth. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of cell growth, positive regulation of DNA-templated transcription; MF: protein binding, transcription coactivator activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Glucocorticoid Receptor Pathway, Nuclear Receptors Meta-Pathway
UniProt: Q14140
Entrez ID: 9792
|
Does Knockout of SRSF10 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
SRSF10
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: SRSF10 (serine and arginine rich splicing factor 10)
Type: protein-coding
Summary: This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: RNA splicing, RNA splicing, via transesterification reactions, cytosolic transport, mRNA processing, mRNA splice site recognition, mRNA splicing, via spliceosome, negative regulation of mRNA splicing, via spliceosome, regulation of DNA-templated transcription, regulation of alternative mRNA splicing, via spliceosome, regulation of mRNA splicing, via spliceosome, spliceosomal tri-snRNP complex assembly; MF: RNA binding, RS domain binding, mRNA binding, nucleic acid binding, protein binding, unfolded protein binding; CC: axon terminus, cytoplasm, cytosol, dendrite, neuronal cell body, nuclear speck, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O75494
Entrez ID: 10772
|
Does Knockout of SIK2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
SIK2
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: SIK2 (salt inducible kinase 2)
Type: protein-coding
Summary: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ERAD pathway, intracellular signal transduction, lipid biosynthetic process, protein autophosphorylation, protein phosphorylation, regulation of insulin receptor signaling pathway; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Glucagon signaling pathway - Homo sapiens (human), LKB1 signaling events
UniProt: Q9H0K1
Entrez ID: 23235
|
Does Knockout of GJA3 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
GJA3
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: GJA3 (gap junction protein alpha 3)
Type: protein-coding
Summary: The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010].
Gene Ontology: BP: cell communication, cell-cell signaling, gap junction-mediated intercellular transport, transmembrane transport, visual perception; MF: gap junction channel activity, gap junction hemi-channel activity; CC: anchoring junction, connexin complex, gap junction, membrane, plasma membrane
Pathways: 1q21.1 copy number variation syndrome, Calcium Regulation in the Cardiac Cell, Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9Y6H8
Entrez ID: 2700
|
Does Knockout of PRELID1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
PRELID1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PRELID1 (PRELI domain containing 1)
Type: protein-coding
Summary: This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: apoptotic process, intermembrane lipid transfer, lipid transport, negative regulation of apoptotic process, negative regulation of mitochondrial membrane potential, negative regulation of release of cytochrome c from mitochondria, phospholipid transport, positive regulation of T cell apoptotic process, positive regulation of cellular respiration, positive regulation of endopeptidase activity, positive regulation of phospholipid transport, regulation of T cell differentiation, regulation of membrane lipid distribution, regulation of mitochondrial membrane potential; MF: phosphatidic acid transfer activity, protein binding; CC: mitochondrial intermembrane space, mitochondrion, nucleoplasm, protein-containing complex
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, Mitochondrial protein degradation, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, Transcriptional Regulation by TP53
UniProt: Q9Y255
Entrez ID: 27166
|
Does Knockout of PRPF31 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
PRPF31
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: PRPF31 (pre-mRNA processing factor 31)
Type: protein-coding
Summary: This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, ribonucleoprotein complex localization, snoRNA localization, spliceosomal tri-snRNP complex assembly; MF: RNA binding, U4 snRNA binding, U4atac snRNA binding, identical protein binding, protein binding, protein-macromolecule adaptor activity, ribonucleoprotein complex binding, snRNP binding; CC: Cajal body, MLL1 complex, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U4atac snRNP, nuclear speck, nucleoplasm, nucleus, precatalytic spliceosome, ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8WWY3
Entrez ID: 26121
|
Does Knockout of SNRPD3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
SNRPD3
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide)
Type: protein-coding
Summary: This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: 7-methylguanosine cap hypermethylation, RNA processing, RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, protein methylation, spliceosomal snRNP assembly; MF: RNA binding, U7 snRNA binding, enzyme binding, histone pre-mRNA DCP binding, protein binding, telomerase RNA binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, commitment complex, cytoplasm, cytosol, methylosome, nuclear body, nucleoplasm, nucleus, pICln-Sm protein complex, precatalytic spliceosome, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex, telomerase holoenzyme complex
Pathways: Disease, Gene expression (Transcription), Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Homo sapiens (human), Systemic lupus erythematosus - Homo sapiens (human), Viral Infection Pathways, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62318
Entrez ID: 6634
|
Does Knockout of HSCB in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
HSCB
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: HSCB (HscB mitochondrial iron-sulfur cluster cochaperone)
Type: protein-coding
Summary: This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: [2Fe-2S] cluster assembly, iron-sulfur cluster assembly, primitive erythrocyte differentiation, primitive hemopoiesis, protein complex oligomerization; MF: ATPase activator activity, identical protein binding, metal ion binding, molecular_function, protein binding, protein-folding chaperone binding; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Complex III assembly, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Mitochondrial protein import, Protein localization, Respiratory electron transport
UniProt: Q8IWL3
Entrez ID: 150274
|
Does Knockout of MTRNR2L7 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
MTRNR2L7
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: MTRNR2L7 (MT-RNR2 like 7 (pseudogene))
Type: pseudo
Summary: Predicted to enable receptor antagonist activity. Predicted to be involved in negative regulation of execution phase of apoptosis. Predicted to be located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, extracellular region
Pathways:
UniProt:
Entrez ID: 100288485
|
Does Knockout of LZTFL1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
LZTFL1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: LZTFL1 (leucine zipper transcription factor like 1)
Type: protein-coding
Summary: This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: flagellated sperm motility, negative regulation of protein localization to ciliary membrane, negative regulation of protein localization to cilium, spermatogenesis; MF: identical protein binding, protein binding, protein-containing complex binding; CC: cilium, cytoplasm, cytosol, manchette
Pathways: BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, Ciliary landscape, Ciliopathies, Cilium Assembly, Genes related to primary cilium development (based on CRISPR), Organelle biogenesis and maintenance
UniProt: Q9NQ48
Entrez ID: 54585
|
Does Knockout of ZNF510 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
ZNF510
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ZNF510 (zinc finger protein 510)
Type: protein-coding
Summary: This gene encodes a krueppel C2H2-type zinc-finger protein family member. The encoded protein is expressed in several cancer cell types and may be a biomarker for early diagnosis of these cancers. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of macromolecule metabolic process, regulation of primary metabolic process, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9Y2H8
Entrez ID: 22869
|
Does Activation of CEP95 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
CEP95
|
response to virus
|
Hepatoma Cell Line
|
Gene: CEP95 (centrosomal protein 95)
Type: protein-coding
Summary: Located in centrosome and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: centrosome, cytoplasm, cytoskeleton, spindle pole
Pathways:
UniProt: Q96GE4
Entrez ID: 90799
|
Does Knockout of PTCD1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
PTCD1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: PTCD1 (pentatricopeptide repeat domain 1)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein that binds leucine tRNAs and other mitochondrial RNAs and plays a role in the regulation of translation. Increased expression of this gene results in decreased mitochondrial leucine tRNA levels. Naturally occurring read-through transcription exists between upstream ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and this gene. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: mitochondrial translation, tRNA 3'-end processing, tRNA processing; MF: RNA binding, protein binding, tRNA binding; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: O75127
Entrez ID: 26024
|
Does Knockout of NAA15 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
NAA15
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit)
Type: protein-coding
Summary: N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: N-terminal protein amino acid acetylation, angiogenesis, cell differentiation, negative regulation of apoptotic process, positive regulation of DNA-templated transcription, protein stabilization; MF: RNA binding, acetyltransferase activator activity, acetyltransferase activity, protein binding, ribosome binding; CC: NatA complex, cytoplasm, cytosol, membrane, nuclear body, nucleus, transcription regulator complex
Pathways:
UniProt: Q9BXJ9
Entrez ID: 80155
|
Does Knockout of FCRL5 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
FCRL5
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: FCRL5 (Fc receptor like 5)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: B cell activation, cell surface receptor signaling pathway, immune response, single fertilization; MF: coreceptor activity, protein binding, transmembrane signaling receptor activity; CC: cell surface, external side of plasma membrane, membrane, plasma membrane, receptor complex
Pathways:
UniProt: Q96RD9
Entrez ID: 83416
|
Does Knockout of CTNND2 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
CTNND2
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: CTNND2 (catenin delta 2)
Type: protein-coding
Summary: This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: Wnt signaling pathway, cell adhesion, cell-cell adhesion, dendritic spine morphogenesis, regulation of canonical Wnt signaling pathway, signal transduction, synapse organization; MF: beta-catenin binding, cadherin binding, protein binding; CC: adherens junction, anchoring junction, cell projection, cytoplasm, dendrite, nucleus, perikaryon, plasma membrane, postsynaptic density
Pathways: Ectoderm Differentiation, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q9UQB3
Entrez ID: 1501
|
Does Knockout of CHURC1-FNTB in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
CHURC1-FNTB
|
response to virus
|
Hepatoma Cell Line
|
Gene: CHURC1-FNTB (CHURC1-FNTB readthrough)
Type: protein-coding
Summary: This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011].
Gene Ontology:
Pathways: Disease, Inactivation, recovery and regulation of the phototransduction cascade, Infectious disease, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Potential therapeutics for SARS, RAF/MAP kinase cascade, RAS processing, SARS-CoV Infections, Sensory Perception, Signal Transduction, The phototransduction cascade, Viral Infection Pathways, Visual phototransduction
UniProt: P49356
Entrez ID: 100529261
|
Does Knockout of CDK17 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
CDK17
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CDK17 (cyclin dependent kinase 17)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: protein phosphorylation, regulation of cell cycle phase transition; MF: ATP binding, cyclin-dependent protein serine/threonine kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q00537
Entrez ID: 5128
|
Does Knockout of TBC1D12 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
TBC1D12
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TBC1D12 (TBC1 domain family member 12)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and regulation of autophagosome assembly. Predicted to be active in autophagosome and recycling endosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of autophagosome assembly, vesicle-mediated transport; MF: GTPase activator activity, enzyme binding; CC: autophagosome, cytoplasmic vesicle, endosome, recycling endosome, vacuole
Pathways:
UniProt: O60347
Entrez ID: 23232
|
Does Knockout of TICAM2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
TICAM2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TICAM2 (TIR domain containing adaptor molecule 2)
Type: protein-coding
Summary: TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]
Gene Ontology: BP: TRAM-dependent toll-like receptor 4 signaling pathway, TRIF-dependent toll-like receptor signaling pathway, cellular response to lipopolysaccharide, immune system process, inflammatory response, innate immune response, negative regulation of chemokine (C-C motif) ligand 5 production, negative regulation of toll-like receptor 4 signaling pathway, phagocytosis, positive regulation of canonical NF-kappaB signal transduction, positive regulation of chemokine (C-C motif) ligand 5 production, positive regulation of interleukin-18-mediated signaling pathway, positive regulation of toll-like receptor 4 signaling pathway, positive regulation of type I interferon production, response to other organism, signal transduction, toll-like receptor 4 signaling pathway; MF: molecular adaptor activity, protein binding, signaling adaptor activity; CC: Golgi apparatus, cell projection, cytoplasm, early endosome, early endosome membrane, endoplasmic reticulum, endosome, endosome membrane, late endosome, late endosome membrane, membrane, phagocytic cup, plasma membrane, secretory granule membrane
Pathways: Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Apoptosis, Caspase activation via Death Receptors in the presence of ligand, Caspase activation via extrinsic apoptotic signalling pathway, Fibrin Complement Receptor 3 Signaling Pathway, Hepatitis B - Homo sapiens (human), Hepatitis B infection, IKK complex recruitment mediated by RIP1, IL-18 signaling pathway, IL1-mediated signaling events, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, Immune System, Innate Immune System, Lipid and atherosclerosis - Homo sapiens (human), MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , NF-kappa B signaling pathway - Homo sapiens (human), Necroptosis - Homo sapiens (human), Neutrophil degranulation, PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), Pertussis - Homo sapiens (human), Programmed Cell Death, Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of toll-like receptor signaling pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , TRIF-mediated programmed cell death, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll-like Receptor Cascades, Toll-like Receptor Signaling Pathway, Toll-like Receptor Signaling related to MyD88, Toll-like receptor signaling pathway - Homo sapiens (human)
UniProt: Q86XR7
Entrez ID: 353376
|
Does Knockout of MIR1226 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
MIR1226
|
response to virus
|
Hepatoma Cell Line
|
Gene: MIR1226 (microRNA 1226)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100302232
|
Does Knockout of TXLNA in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
TXLNA
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: TXLNA (taxilin alpha)
Type: protein-coding
Summary: Predicted to enable syntaxin binding activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within B cell activation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: B cell activation, exocytosis; MF: protein binding, syntaxin binding; CC: cytoplasm, cytosol, extracellular region, membrane
Pathways: Cytokine Signaling in Immune system, Immune System, Other interleukin signaling, Signaling by Interleukins, TNFalpha
UniProt: P40222
Entrez ID: 200081
|
Does Knockout of TMOD2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
TMOD2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: TMOD2 (tropomodulin 2)
Type: protein-coding
Summary: This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008].
Gene Ontology: BP: actin filament organization, learning or memory, muscle contraction, myofibril assembly, nervous system development, neuron-neuron synaptic transmission, pointed-end actin filament capping, positive regulation of G protein-coupled receptor signaling pathway; MF: actin binding, protein binding, tropomyosin binding; CC: cytoplasm, cytoskeleton, myofibril, striated muscle thin filament, synapse
Pathways: Muscle contraction, Striated Muscle Contraction
UniProt: Q9NZR1
Entrez ID: 29767
|
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