prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of ANAPC1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | ANAPC1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ANAPC1 (anaphase promoting complex subunit 1)
Type: protein-coding
Summary: This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which ... |
Does Knockout of CKS1B in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | CKS1B | cell proliferation | Monocytic Leukemia Cell Line | Gene: CKS1B (CDC28 protein kinase regulatory subunit 1B)
Type: protein-coding
Summary: CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa... |
Does Knockout of DDX23 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 1 | 1,996 | Knockout | DDX23 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: DDX23 (DEAD-box helicase 23)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alterati... |
Does Knockout of MORF4L1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | MORF4L1 | cell proliferation | Melanoma Cell Line | Gene: MORF4L1 (mortality factor 4 like 1)
Type: protein-coding
Summary: Enables protein N-terminus binding activity. Involved in double-strand break repair via homologous recombination and histone modification. Located in nuclear speck. Part of NuA4 histone acetyltransferase complex and Sin3 complex. [p... |
Does Knockout of DCTN6 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | DCTN6 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: DCTN6 (dynactin subunit 6)
Type: protein-coding
Summary: The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homol... |
Does Knockout of COMMD6 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | COMMD6 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: COMMD6 (COMM domain containing 6)
Type: protein-coding
Summary: COMMD6 belongs to a family of NF-kappa-B (see RELA; MIM 164014)-inhibiting proteins characterized by the presence of a COMM domain (see COMMD1; MIM 607238) (de Bie et al., 2006 [PubMed 16573520]).[supplied by OMIM, Mar 2009].
... |
Does Knockout of DPH6 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | DPH6 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: DPH6 (diphthamine biosynthesis 6)
Type: protein-coding
Summary: Enables diphthine-ammonia ligase activity. Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of TLE3 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | TLE3 | cell proliferation | Colonic Cancer Cell Line | Gene: TLE3 (TLE family member 3, transcriptional corepressor)
Type: protein-coding
Summary: This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determin... |
Does Knockout of NUP133 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | NUP133 | cell proliferation | Monocytic Leukemia Cell Line | Gene: NUP133 (nucleoporin 133)
Type: protein-coding
Summary: The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of mac... |
Does Knockout of OR9G4 in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | OR9G4 | cell proliferation | Bladder Carcinoma | Gene: OR9G4 (olfactory receptor family 9 subfamily G member 4)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of PPIP5K2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | PPIP5K2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2)
Type: protein-coding
Summary: This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is th... |
Does Knockout of REV1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | REV1 | cell proliferation | Colonic Cancer Cell Line | Gene: REV1 (REV1 DNA directed polymerase)
Type: protein-coding
Summary: This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein... |
Does Knockout of LYG2 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | LYG2 | cell proliferation | Breast Cancer Cell Line | Gene: LYG2 (lysozyme g2)
Type: protein-coding
Summary: The protein encoded by this gene contains a SLT domain, a protein domain present in bacterial lytic transglycosylase (SLT) and in eukaryotic lysozymes (GEWL). SLT domain catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic ... |
Does Knockout of RPS13 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | RPS13 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: RPS13 (ribosomal protein S13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of ADAT2 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | ADAT2 | cell proliferation | Glioblastoma Cell Line | Gene: ADAT2 (adenosine deaminase tRNA specific 2)
Type: protein-coding
Summary: Predicted to enable tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA wobble adenosine to inosine editing. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr ... |
Does Knockout of TACR2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | TACR2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: TACR2 (tachykinin receptor 2)
Type: protein-coding
Summary: This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions w... |
Does Knockout of DMBX1 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | DMBX1 | response to virus | Huh-7 Cell | Gene: DMBX1 (diencephalon/mesencephalon homeobox 1)
Type: protein-coding
Summary: This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. Two transc... |
Does Knockout of ZNF320 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | ZNF320 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: ZNF320 (zinc finger protein 320)
Type: protein-coding
Summary: ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription.[supplied by OMIM, Jul 2002].
Gene Ontology: BP: regulation of DNA-templated transcrip... |
Does Knockout of CIB3 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | CIB3 | cell proliferation | Renal Cancer Cell Line | Gene: CIB3 (calcium and integrin binding family member 3)
Type: protein-coding
Summary: This gene product shares a high degree of sequence similarity with DNA-dependent protein kinase catalytic subunit-interacting protein 2 in human and mouse, and like them may bind the catalytic subunit of DNA-dependen... |
Does Knockout of MIEN1 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | MIEN1 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: MIEN1 (migration and invasion enhancer 1)
Type: protein-coding
Summary: Involved in negative regulation of apoptotic process; positive regulation of cell migration; and positive regulation of filopodium assembly. Located in several cellular components, including centriolar satellite; cytosol; and ... |
Does Knockout of N4BP2L2 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | N4BP2L2 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: N4BP2L2 (NEDD4 binding protein 2 like 2)
Type: protein-coding
Summary: Enables enzyme binding activity. Involved in negative regulation of hematopoietic stem cell differentiation and positive regulation of hematopoietic stem cell proliferation. Located in nucleus. Part of transcription repressor c... |
Does Knockout of HLA-A in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | HLA-A | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: HLA-A (major histocompatibility complex, class I, A)
Type: protein-coding
Summary: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Clas... |
Does Knockout of SH2D2A in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | SH2D2A | response to chemicals | Monocytic Leukemia Cell Line | Gene: SH2D2A (SH2 domain containing 2A)
Type: protein-coding
Summary: This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling.... |
Does Knockout of EMC10 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | EMC10 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: EMC10 (ER membrane protein complex subunit 10)
Type: protein-coding
Summary: Contributes to membrane insertase activity. Involved in positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; and protein insertion into ER membrane. Located in extracellular region. ... |
Does Knockout of ZC3H15 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | ZC3H15 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: ZC3H15 (zinc finger CCCH-type containing 15)
Type: protein-coding
Summary: Enables RNA binding activity and cadherin binding activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytokine-m... |
Does Knockout of KAT8 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | KAT8 | cell proliferation | Cancer Cell Line | Gene: KAT8 (lysine acetyltransferase 8)
Type: protein-coding
Summary: This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-ty... |
Does Knockout of GRM8 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | GRM8 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: GRM8 (glutamate metabotropic receptor 8)
Type: protein-coding
Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain ... |
Does Knockout of NUBP1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | NUBP1 | cell proliferation | Colonic Cancer Cell Line | Gene: NUBP1 (NUBP iron-sulfur cluster assembly factor 1, cytosolic)
Type: protein-coding
Summary: NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell projection organization, centros... |
Does Knockout of DCLRE1C in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | DCLRE1C | RNA accumulation | Monocytic Leukemia Cell Line | Gene: DCLRE1C (DNA cross-link repair 1C)
Type: protein-coding
Summary: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and ... |
Does Knockout of SULT1E1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | SULT1E1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SULT1E1 (sulfotransferase family 1E member 1)
Type: protein-coding
Summary: Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificitie... |
Does Knockout of ABHD10 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | ABHD10 | response to chemicals | Glioblastoma Cell Line | Gene: ABHD10 (abhydrolase domain containing 10, depalmitoylase)
Type: protein-coding
Summary: This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene... |
Does Knockout of RFC2 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | RFC2 | cell proliferation | Medulloblastoma Cell Line | Gene: RFC2 (replication factor C subunit 2)
Type: protein-coding
Summary: This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCN... |
Does Knockout of CNOT3 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | CNOT3 | cell proliferation | Gastric Cancer Cell Line | Gene: CNOT3 (CCR4-NOT transcription complex subunit 3)
Type: protein-coding
Summary: Involved in regulation of stem cell population maintenance. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: nuclear-transcribed mRNA poly(A) tail shortening, po... |
Does Knockout of SAA4 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | SAA4 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: SAA4 (serum amyloid A4, constitutive)
Type: protein-coding
Summary: Predicted to be involved in acute-phase response. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular exosome, extracellular region, high-density lipopro... |
Does Knockout of TTI1 in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | TTI1 | response to virus | Hepatoma Cell Line | Gene: TTI1 (TELO2 interacting protein 1)
Type: protein-coding
Summary: Involved in regulation of TOR signaling. Located in cytoplasm. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of DNA damage checkpoint, pr... |
Does Knockout of MRPS9 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | MRPS9 | cell proliferation | Endometrial Cancer Cell Line | Gene: MRPS9 (mitochondrial ribosomal protein S9)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. T... |
Does Knockout of RPS28 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | RPS28 | cell proliferation | Colonic Cancer Cell Line | Gene: RPS28 (ribosomal protein S28)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of SUMO2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | SUMO2 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: SUMO2 (small ubiquitin like modifier 2)
Type: protein-coding
Summary: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modifi... |
Does Knockout of RACK1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | RACK1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: RACK1 (receptor for activated C kinase 1)
Type: protein-coding
Summary: Enables several functions, including cyclin binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulatio... |
Does Knockout of VPS8 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | VPS8 | response to virus | Hepatoma Cell Line | Gene: VPS8 (VPS8 subunit of CORVET complex)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Involved in endosomal vesicle fusion. Located in early endosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endosomal vesicle fusion, protein ta... |
Does Knockout of NCAPG2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | NCAPG2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: NCAPG2 (non-SMC condensin II complex subunit G2)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chrom... |
Does Knockout of PLCB3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | PLCB3 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: PLCB3 (phospholipase C beta 3)
Type: protein-coding
Summary: This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked r... |
Does Knockout of WDR75 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | WDR75 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: WDR75 (WD repeat domain 75)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology... |
Does Knockout of MED31 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | MED31 | cell proliferation | Prostate Cancer Cell Line | Gene: MED31 (mediator complex subunit 31)
Type: protein-coding
Summary: Predicted to enable transcription coregulator activity and ubiquitin protein ligase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within limb development and ... |
Does Knockout of TCHP in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | TCHP | cell proliferation | Monocytic Leukemia Cell Line | Gene: TCHP (trichoplein keratin filament binding)
Type: protein-coding
Summary: Involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Located in several cellular components, including apical cortex; cytoskeleton; and mitochondrion. [provided by Al... |
Does Knockout of IPO7 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | IPO7 | cell proliferation | Colorectal Cancer Cell Line | Gene: IPO7 (importin 7)
Type: protein-coding
Summary: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequenc... |
Does Knockout of LYZL2 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | LYZL2 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: LYZL2 (lysozyme like 2)
Type: protein-coding
Summary: Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like g... |
Does Knockout of IFT20 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | IFT20 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: IFT20 (intraflagellar transport 20)
Type: protein-coding
Summary: This gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signallin... |
Does Knockout of GNAI3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | GNAI3 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: GNAI3 (G protein subunit alpha i3)
Type: protein-coding
Summary: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and... |
Does Knockout of ZMAT5 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | ZMAT5 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: ZMAT5 (zinc finger matrin-type 5)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in RNA splicing. Located in nucleoplasm. Part of U12-type spliceosomal complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: R... |
Does Knockout of LRRC27 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | LRRC27 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: LRRC27 (leucine rich repeat containing 27)
Type: protein-coding
Summary: leucine rich repeat containing 27
Gene Ontology:
Pathways:
UniProt: Q9C0I9
Entrez ID: 80313 |
Does Knockout of GRAP2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 1 | 1,996 | Knockout | GRAP2 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: GRAP2 (GRB2 related adaptor protein 2)
Type: protein-coding
Summary: This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP),... |
Does Knockout of SLC6A18 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | SLC6A18 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: SLC6A18 (solute carrier family 6 member 18)
Type: protein-coding
Summary: The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the... |
Does Knockout of ZNF559 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | ZNF559 | cell proliferation | Colonic Cancer Cell Line | Gene: ZNF559 (zinc finger protein 559)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation ... |
Does Knockout of EXT1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | EXT1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: EXT1 (exostosin glycosyltransferase 1)
Type: protein-coding
Summary: This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostos... |
Does Knockout of ACTR3 in Glioma Cell Line causally result in protein/peptide accumulation? | 1 | 589 | Knockout | ACTR3 | protein/peptide accumulation | Glioma Cell Line | Gene: ACTR3 (actin related protein 3)
Type: protein-coding
Summary: The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and mot... |
Does Knockout of MCM7 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | MCM7 | cell proliferation | Colonic Cancer Cell Line | Gene: MCM7 (minichromosome maintenance complex component 7)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex forme... |
Does Knockout of ATP2B2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | ATP2B2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: ATP2B2 (ATPase plasma membrane Ca2+ transporting 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove biva... |
Does Activation of TLX3 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | TLX3 | response to virus | Hepatoma Cell Line | Gene: TLX3 (T cell leukemia homeobox 3)
Type: protein-coding
Summary: The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-A... |
Does Knockout of ZKSCAN2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | ZKSCAN2 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ZKSCAN2 (zinc finger with KRAB and SCAN domains 2)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of t... |
Does Knockout of USPL1 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | USPL1 | cell proliferation | Multiple Myeloma Cell Line | Gene: USPL1 (ubiquitin specific peptidase like 1)
Type: protein-coding
Summary: Enables SUMO binding activity and SUMO-specific isopeptidase activity. Involved in several processes, including Cajal body organization; protein desumoylation; and snRNA transcription. Located in Cajal body. [provided by All... |
Does Knockout of PRPF38A in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | PRPF38A | cell proliferation | Multiple Myeloma Cell Line | Gene: PRPF38A (pre-mRNA processing factor 38A)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA sp... |
Does Knockout of NUS1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | NUS1 | cell proliferation | Medulloblastoma Cell Line | Gene: NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit)
Type: protein-coding
Summary: This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded pro... |
Does Knockout of GPS1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | GPS1 | cell proliferation | Colonic Cancer Cell Line | Gene: GPS1 (G protein pathway suppressor 1)
Type: protein-coding
Summary: This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduc... |
Does Knockout of MTG2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | MTG2 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: MTG2 (mitochondrial ribosome associated GTPase 2)
Type: protein-coding
Summary: Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal tra... |
Does Knockout of NMT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | NMT1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: NMT1 (N-myristoyltransferase 1)
Type: protein-coding
Summary: Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catal... |
Does Knockout of PYROXD1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | PYROXD1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1)
Type: protein-coding
Summary: This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other prote... |
Does Knockout of SF3B6 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | SF3B6 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SF3B6 (splicing factor 3b subunit 6)
Type: protein-coding
Summary: This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein inte... |
Does Knockout of ALDH2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | ALDH2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: ALDH2 (aldehyde dehydrogenase 2 family member)
Type: protein-coding
Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, ... |
Does Knockout of MAP1LC3B2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | MAP1LC3B2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: MAP1LC3B2 (microtubule associated protein 1 light chain 3 beta 2)
Type: protein-coding
Summary: Predicted to enable microtubule binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in autophagy of mitochondrion; cellular response to nitrogen starvation; and macr... |
Does Knockout of ZBBX in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | ZBBX | cell proliferation | Colonic Cancer Cell Line | Gene: ZBBX (zinc finger B-box domain containing)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in cilium movement. Predicted to be active in motile cilium. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion b... |
Does Knockout of ZBTB11 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | ZBTB11 | cell proliferation | Bladder Carcinoma | Gene: ZBTB11 (zinc finger and BTB domain containing 11)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of tr... |
Does Knockout of SNIP1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | SNIP1 | cell proliferation | Medulloblastoma Cell Line | Gene: SNIP1 (Smad nuclear interacting protein 1)
Type: protein-coding
Summary: This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transfor... |
Does Knockout of MCM3 in Prostate Cancer Cell Line causally result in response to chemicals? | 1 | 2,109 | Knockout | MCM3 | response to chemicals | Prostate Cancer Cell Line | Gene: MCM3 (minichromosome maintenance complex component 3)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed ... |
Does Knockout of UBE2V1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | UBE2V1 | cell proliferation | Endometrial Cancer Cell Line | Gene: UBE2V1 (ubiquitin conjugating enzyme E2 V1)
Type: protein-coding
Summary: Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that... |
Does Knockout of AAMP in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | AAMP | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: AAMP (angio associated migratory cell protein)
Type: protein-coding
Summary: The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate ... |
Does Knockout of ZNF491 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | ZNF491 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: ZNF491 (zinc finger protein 491)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation ... |
Does Knockout of SERTAD2 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | SERTAD2 | cell proliferation | Ovarian Cancer Cell Line | Gene: SERTAD2 (SERTA domain containing 2)
Type: protein-coding
Summary: Predicted to enable transcription coactivator activity. Acts upstream of or within negative regulation of cell growth. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: ... |
Does Knockout of SRSF10 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | SRSF10 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: SRSF10 (serine and arginine rich splicing factor 10)
Type: protein-coding
Summary: This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motif... |
Does Knockout of SIK2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | SIK2 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: SIK2 (salt inducible kinase 2)
Type: protein-coding
Summary: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein autophosphorylation. Predicted to be located in nucleus. Predicted to b... |
Does Knockout of GJA3 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | GJA3 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: GJA3 (gap junction protein alpha 3)
Type: protein-coding
Summary: The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010].
Gene Ontology: B... |
Does Knockout of PRELID1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | PRELID1 | cell proliferation | Colonic Cancer Cell Line | Gene: PRELID1 (PRELI domain containing 1)
Type: protein-coding
Summary: This gene encodes a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation. Alter... |
Does Knockout of PRPF31 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | PRPF31 | cell proliferation | Colorectal Cancer Cell Line | Gene: PRPF31 (pre-mRNA processing factor 31)
Type: protein-coding
Summary: This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009].
... |
Does Knockout of SNRPD3 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | SNRPD3 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide)
Type: protein-coding
Summary: This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants. [provided by ... |
Does Knockout of HSCB in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | HSCB | response to chemicals | Monocytic Leukemia Cell Line | Gene: HSCB (HscB mitochondrial iron-sulfur cluster cochaperone)
Type: protein-coding
Summary: This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are... |
Does Knockout of MTRNR2L7 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | MTRNR2L7 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: MTRNR2L7 (MT-RNR2 like 7 (pseudogene))
Type: pseudo
Summary: Predicted to enable receptor antagonist activity. Predicted to be involved in negative regulation of execution phase of apoptosis. Predicted to be located in cytoplasm and extracellular region. [provided by Alliance of Genome Resources, ... |
Does Knockout of LZTFL1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | LZTFL1 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: LZTFL1 (leucine zipper transcription factor like 1)
Type: protein-coding
Summary: This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates ... |
Does Knockout of ZNF510 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | ZNF510 | cell proliferation | Colonic Cancer Cell Line | Gene: ZNF510 (zinc finger protein 510)
Type: protein-coding
Summary: This gene encodes a krueppel C2H2-type zinc-finger protein family member. The encoded protein is expressed in several cancer cell types and may be a biomarker for early diagnosis of these cancers. [provided by RefSeq, Sep 2015].
... |
Does Activation of CEP95 in Hepatoma Cell Line causally result in response to virus? | 0 | 1,210 | Activation | CEP95 | response to virus | Hepatoma Cell Line | Gene: CEP95 (centrosomal protein 95)
Type: protein-coding
Summary: Located in centrosome and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: centrosome, cytoplasm, cytoskeleton, spindle pole
Pathways:
UniProt: Q96GE4
Entrez ID: 90... |
Does Knockout of PTCD1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | PTCD1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: PTCD1 (pentatricopeptide repeat domain 1)
Type: protein-coding
Summary: This gene encodes a mitochondrial protein that binds leucine tRNAs and other mitochondrial RNAs and plays a role in the regulation of translation. Increased expression of this gene results in decreased mitochondrial leucine tR... |
Does Knockout of NAA15 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | NAA15 | cell proliferation | Colorectal Cancer Cell Line | Gene: NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit)
Type: protein-coding
Summary: N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino grou... |
Does Knockout of FCRL5 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | FCRL5 | cell proliferation | Gastric Cancer Cell Line | Gene: FCRL5 (Fc receptor like 5)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-p... |
Does Knockout of CTNND2 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | CTNND2 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: CTNND2 (catenin delta 2)
Type: protein-coding
Summary: This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin bas... |
Does Knockout of CHURC1-FNTB in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | CHURC1-FNTB | response to virus | Hepatoma Cell Line | Gene: CHURC1-FNTB (CHURC1-FNTB readthrough)
Type: protein-coding
Summary: This locus represents naturally occurring read-through transcription between the neighboring CHURC1 (churchill domain containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on chromosome 14. The read-through transcript produ... |
Does Knockout of CDK17 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | CDK17 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: CDK17 (cyclin dependent kinase 17)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively splic... |
Does Knockout of TBC1D12 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | TBC1D12 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: TBC1D12 (TBC1 domain family member 12)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity; intracellular protein transport; and regulation of autophagosome assembly. Predicted to be active in autophagosome and recy... |
Does Knockout of TICAM2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | TICAM2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: TICAM2 (TIR domain containing adaptor molecule 2)
Type: protein-coding
Summary: TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]
Gene Ontology: BP: TRAM-... |
Does Knockout of MIR1226 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | MIR1226 | response to virus | Hepatoma Cell Line | Gene: MIR1226 (microRNA 1226)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of TXLNA in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | TXLNA | cell proliferation | Medulloblastoma Cell Line | Gene: TXLNA (taxilin alpha)
Type: protein-coding
Summary: Predicted to enable syntaxin binding activity. Predicted to be involved in exocytosis. Predicted to act upstream of or within B cell activation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP... |
Does Knockout of TMOD2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | TMOD2 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: TMOD2 (tropomodulin 2)
Type: protein-coding
Summary: This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this prote... |
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