prompt
string
hit
int64
screen_id
int64
crispr_strategy
string
gene
string
phenotype
string
cell_type
string
gene_context
string
Does Knockout of POLR2F in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
1
180
Knockout
POLR2F
cell proliferation
Urinary Bladder Cancer Cell Line
Gene: POLR2F (RNA polymerase II, I and III subunit F) Type: protein-coding Summary: This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunit...
Does Knockout of CUL4A in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
0
1,340
Knockout
CUL4A
response to chemicals
Retinal Pigment Epithelium Cell Line
Gene: CUL4A (cullin 4A) Type: protein-coding Summary: CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]. Gene Ontology: BP: DNA damage response, DNA repair...
Does Knockout of TRAF7 in Bladder Carcinoma causally result in cell proliferation?
0
489
Knockout
TRAF7
cell proliferation
Bladder Carcinoma
Gene: TRAF7 (TNF receptor associated factor 7) Type: protein-coding Summary: Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine...
Does Knockout of LEMD3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
0
897
Knockout
LEMD3
cell proliferation
Lung Adenocarcinoma Cell Line
Gene: LEMD3 (LEM domain containing 3) Type: protein-coding Summary: This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found...
Does Knockout of RAVER1 in Cancer Cell Line causally result in cell proliferation?
0
1,308
Knockout
RAVER1
cell proliferation
Cancer Cell Line
Gene: RAVER1 (ribonucleoprotein, PTB binding 1) Type: protein-coding Summary: Enables RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resou...
Does Knockout of ALG13 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
1
2,119
Knockout
ALG13
cell proliferation
Primary Effusion Lymphoma Cell Line
Gene: ALG13 (ALG13 UDP-N-acetylglucosaminyltransferase subunit) Type: protein-coding Summary: The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltrans...
Does Knockout of CISD1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
0
69
Knockout
CISD1
cell proliferation
Monocytic Leukemia Cell Line
Gene: CISD1 (CDGSH iron sulfur domain 1) Type: protein-coding Summary: This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in reg...
Does Knockout of SPAG16 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
0
1,339
Knockout
SPAG16
response to chemicals
Retinal Pigment Epithelium Cell Line
Gene: SPAG16 (sperm associated antigen 16) Type: protein-coding Summary: Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the...
Does Knockout of RUBCN in Monocytic Leukemia Cell Line causally result in cell proliferation?
1
69
Knockout
RUBCN
cell proliferation
Monocytic Leukemia Cell Line
Gene: RUBCN (rubicon autophagy regulator) Type: protein-coding Summary: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain....
Does Knockout of SUSD2 in Bladder Carcinoma causally result in cell proliferation?
0
489
Knockout
SUSD2
cell proliferation
Bladder Carcinoma
Gene: SUSD2 (sushi domain containing 2) Type: protein-coding Summary: Involved in negative regulation of cell cycle G1/S phase transition and negative regulation of cell division. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontology: BP: negative regula...
Does Knockout of GCN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
1
305
Knockout
GCN1
cell proliferation
Lung Squamous Cell Carcinoma Cell Line
Gene: GCN1 (GCN1 activator of EIF2AK4) Type: protein-coding Summary: Enables RNA binding activity and cadherin binding activity. Predicted to be involved in cellular response to leucine starvation and positive regulation of transcription from RNA polymerase II promoter in response to stress. Located in ...
Does Knockout of EIF3C in Cancer Cell Line causally result in cell proliferation?
1
948
Knockout
EIF3C
cell proliferation
Cancer Cell Line
Gene: EIF3C (eukaryotic translation initiation factor 3 subunit C) Type: protein-coding Summary: Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initi...
Does Knockout of RPL13 in Astrocytoma Cell Line causally result in cell proliferation?
1
904
Knockout
RPL13
cell proliferation
Astrocytoma Cell Line
Gene: RPL13 (ribosomal protein L13) Type: protein-coding Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode...
Does Knockout of FIS1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
0
1,061
Knockout
FIS1
response to chemicals
Primary Effusion Lymphoma Cell Line
Gene: FIS1 (fission, mitochondrial 1) Type: protein-coding Summary: The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008] ...
Does Knockout of PIGM in Ovarian Cancer Cell Line causally result in cell proliferation?
0
699
Knockout
PIGM
cell proliferation
Ovarian Cancer Cell Line
Gene: PIGM (phosphatidylinositol glycan anchor biosynthesis class M) Type: protein-coding Summary: This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contai...
Does Knockout of TMEM65 in Medulloblastoma Cell Line causally result in cell proliferation?
0
1,813
Knockout
TMEM65
cell proliferation
Medulloblastoma Cell Line
Gene: TMEM65 (transmembrane protein 65) Type: protein-coding Summary: Predicted to be involved in cardiac ventricle development and regulation of cardiac conduction. Located in intercalated disc; mitochondrial inner membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022] ...
Does Knockout of TJP3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
1
1,658
Knockout
TJP3
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: TJP3 (tight junction protein 3) Type: protein-coding Summary: The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like ...
Does Knockout of RAB5C in Bladder Carcinoma causally result in cell proliferation?
1
489
Knockout
RAB5C
cell proliferation
Bladder Carcinoma
Gene: RAB5C (RAB5C, member RAS oncogene family) Type: protein-coding Summary: Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubM...
Does Knockout of UROD in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
1
305
Knockout
UROD
cell proliferation
Lung Squamous Cell Carcinoma Cell Line
Gene: UROD (uroporphyrinogen decarboxylase) Type: protein-coding Summary: This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and ...
Does Knockout of S100A11 in Colonic Cancer Cell Line causally result in cell proliferation?
0
865
Knockout
S100A11
cell proliferation
Colonic Cancer Cell Line
Gene: S100A11 (S100 calcium binding protein A11) Type: protein-coding Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in th...
Does Knockout of NCKAP1 in Cancer Cell Line causally result in cell proliferation?
1
948
Knockout
NCKAP1
cell proliferation
Cancer Cell Line
Gene: NCKAP1 (NCK associated protein 1) Type: protein-coding Summary: Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of lamellipodium assembly. Located in extracellular ex...
Does Knockout of ZGRF1 in Astrocytoma Cell Line causally result in cell proliferation?
0
904
Knockout
ZGRF1
cell proliferation
Astrocytoma Cell Line
Gene: ZGRF1 (zinc finger GRF-type containing 1) Type: protein-coding Summary: The encoded protein contains GRF zinc finger (zf-GRF) and transmembrane domains. GRF zinc fingers are found in a number of DNA-binding proteins. Alternative splicing results in multiple transcript variants encoding different i...
Does Knockout of UST in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
0
387
Knockout
UST
cell proliferation
Lung Adenocarcinoma Cell Line
Gene: UST (uronyl 2-sulfotransferase) Type: protein-coding Summary: Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM,...
Does Knockout of RAB7A in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
0
1,996
Knockout
RAB7A
cell proliferation
Pre-B Acute Lymphoblastic Leukemia Cell Line
Gene: RAB7A (RAB7A, member RAS oncogene family) Type: protein-coding Summary: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB...
Does Activation of KIF3A in Hepatoma Cell Line causally result in response to virus?
0
1,210
Activation
KIF3A
response to virus
Hepatoma Cell Line
Gene: KIF3A (kinesin family member 3A) Type: protein-coding Summary: Enables protein phosphatase binding activity; small GTPase binding activity; and spectrin binding activity. Involved in protein localization to cell junction and protein transport. Located in centriole and centrosome. Part of kinesin I...
Does Knockout of PSD in Colonic Cancer Cell Line causally result in cell proliferation?
0
951
Knockout
PSD
cell proliferation
Colonic Cancer Cell Line
Gene: PSD (pleckstrin and Sec7 domain containing) Type: protein-coding Summary: This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Al...
Does Knockout of GJC3 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
0
1,061
Knockout
GJC3
response to chemicals
Primary Effusion Lymphoma Cell Line
Gene: GJC3 (gap junction protein gamma 3) Type: protein-coding Summary: This gene encodes a gap junction protein. The encoded protein, also known as a connexin, plays a role in formation of gap junctions, which provide direct connections between neighboring cells. Mutations in this gene have been report...
Does Knockout of NAA30 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
1
1,340
Knockout
NAA30
response to chemicals
Retinal Pigment Epithelium Cell Line
Gene: NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit) Type: protein-coding Summary: Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal peptidyl-methionine acetylation. Located in cytosol and nucleus. Part of NatC complex. Colocalizes with polysome. [provided by Allia...
Does Knockout of MRPL10 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
1
305
Knockout
MRPL10
cell proliferation
Lung Squamous Cell Carcinoma Cell Line
Gene: MRPL10 (mitochondrial ribosomal protein L10) Type: protein-coding Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit....
Does Activation of THBS3 in T cell causally result in protein/peptide accumulation?
1
2,426
Activation
THBS3
protein/peptide accumulation
T cell
Gene: THBS3 (thrombospondin 3) Type: protein-coding Summary: The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a sin...
Does Activation of PDCD2 in Hepatoma Cell Line causally result in response to virus?
0
1,210
Activation
PDCD2
response to virus
Hepatoma Cell Line
Gene: PDCD2 (programmed cell death 2) Type: protein-coding Summary: This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center developme...
Does Knockout of UCKL1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
0
1,329
Knockout
UCKL1
response to chemicals
Retinal Pigment Epithelium Cell Line
Gene: UCKL1 (uridine-cytidine kinase 1 like 1) Type: protein-coding Summary: The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural ki...
Does Knockout of CTPS2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
0
2,119
Knockout
CTPS2
cell proliferation
Primary Effusion Lymphoma Cell Line
Gene: CTPS2 (CTP synthase 2) Type: protein-coding Summary: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role ...
Does Knockout of UNC45A in Lung Cancer Cell Line causally result in response to radiation?
1
1,952
Knockout
UNC45A
response to radiation
Lung Cancer Cell Line
Gene: UNC45A (unc-45 myosin chaperone A) Type: protein-coding Summary: This gene encodes a regulatory component of the progesterone receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the progesterone receptor. The encoded protein is thought to be essential...
Does Knockout of PCDH17 in Endometrial Cancer Cell Line causally result in cell proliferation?
0
758
Knockout
PCDH17
cell proliferation
Endometrial Cancer Cell Line
Gene: PCDH17 (protocadherin 17) Type: protein-coding Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical...
Does Knockout of DCLRE1C in Monocytic Leukemia Cell Line causally result in cell proliferation?
0
69
Knockout
DCLRE1C
cell proliferation
Monocytic Leukemia Cell Line
Gene: DCLRE1C (DNA cross-link repair 1C) Type: protein-coding Summary: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and ...
Does Knockout of PEX11A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
0
1,789
Knockout
PEX11A
cell proliferation
Chronic Myeloid Leukemia Cell Line
Gene: PEX11A (peroxisomal biogenesis factor 11 alpha) Type: protein-coding Summary: This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protei...
Does Knockout of MYO1D in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
0
305
Knockout
MYO1D
cell proliferation
Lung Squamous Cell Carcinoma Cell Line
Gene: MYO1D (myosin ID) Type: protein-coding Summary: Enables protein domain specific binding activity. Predicted to be involved in actin filament organization; early endosome to recycling endosome transport; and vesicle transport along actin filament. Located in extracellular exosome. [provided by Alli...
Does Activation of KCNE3 in T cell causally result in protein/peptide accumulation?
0
2,425
Activation
KCNE3
protein/peptide accumulation
T cell
Gene: KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3) Type: protein-coding Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating ne...
Does Knockout of IGLL5 in Monocytic Leukemia Cell Line causally result in cell proliferation?
0
69
Knockout
IGLL5
cell proliferation
Monocytic Leukemia Cell Line
Gene: IGLL5 (immunoglobulin lambda like polypeptide 5) Type: protein-coding Summary: This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unr...
Does Knockout of L3MBTL1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
0
206
Knockout
L3MBTL1
cell proliferation
Monocytic Leukemia Cell Line
Gene: L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1) Type: protein-coding Summary: This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively splice...
Does Knockout of GPN1 in Gastric Cancer Cell Line causally result in cell proliferation?
1
230
Knockout
GPN1
cell proliferation
Gastric Cancer Cell Line
Gene: GPN1 (GPN-loop GTPase 1) Type: protein-coding Summary: This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 200...
Does Knockout of SNUPN in Breast Cancer Cell Line causally result in cell proliferation?
1
235
Knockout
SNUPN
cell proliferation
Breast Cancer Cell Line
Gene: SNUPN (snurportin 1) Type: protein-coding Summary: The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the S...
Does Knockout of CTNNBL1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
1
734
Knockout
CTNNBL1
cell proliferation
Large Cell Lung Cancer Cell Line
Gene: CTNNBL1 (catenin beta like 1) Type: protein-coding Summary: The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded prote...
Does Knockout of GTF3C5 in Cancer Cell Line causally result in cell proliferation?
0
1,308
Knockout
GTF3C5
cell proliferation
Cancer Cell Line
Gene: GTF3C5 (general transcription factor IIIC subunit 5) Type: protein-coding Summary: Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and tRNA transcription by RNA polymerase III. Predicted to act upstream of or within ske...
Does Knockout of IL24 in Colonic Cancer Cell Line causally result in cell proliferation?
0
815
Knockout
IL24
cell proliferation
Colonic Cancer Cell Line
Gene: IL24 (interleukin 24) Type: protein-coding Summary: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpr...
Does Knockout of YBX1 in Medulloblastoma Cell Line causally result in cell proliferation?
1
1,813
Knockout
YBX1
cell proliferation
Medulloblastoma Cell Line
Gene: YBX1 (Y-box binding protein 1) Type: protein-coding Summary: This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes inc...
Does Knockout of KRTAP3-1 in Cancer Cell Line causally result in cell proliferation?
0
193
Knockout
KRTAP3-1
cell proliferation
Cancer Cell Line
Gene: KRTAP3-1 (keratin associated protein 3-1) Type: protein-coding Summary: This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have uniq...
Does Knockout of TEKT3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
0
1,340
Knockout
TEKT3
response to chemicals
Retinal Pigment Epithelium Cell Line
Gene: TEKT3 (tektin 3) Type: protein-coding Summary: This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided b...
Does Knockout of PAN2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
1
1,397
Knockout
PAN2
response to chemicals
Chronic Myeloid Leukemia Cell Line
Gene: PAN2 (poly(A) specific ribonuclease subunit PAN2) Type: protein-coding Summary: This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease tha...
Does Knockout of CHRNA3 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
0
1,461
Knockout
CHRNA3
protein/peptide accumulation
Embryonic Kidney Cell Line
Gene: CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit) Type: protein-coding Summary: This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes a...
Does Knockout of SSB in Endometrial Cancer Cell Line causally result in cell proliferation?
1
287
Knockout
SSB
cell proliferation
Endometrial Cancer Cell Line
Gene: SSB (small RNA binding exonuclease protection factor La) Type: protein-coding Summary: The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processin...
Does Knockout of MCM2 in Colorectal Cancer Cell Line causally result in cell proliferation?
1
783
Knockout
MCM2
cell proliferation
Colorectal Cancer Cell Line
Gene: MCM2 (minichromosome maintenance complex component 2) Type: protein-coding Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed ...
Does Knockout of EXOSC8 in Ovarian Cancer Cell Line causally result in cell proliferation?
1
699
Knockout
EXOSC8
cell proliferation
Ovarian Cancer Cell Line
Gene: EXOSC8 (exosome component 8) Type: protein-coding Summary: This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of...
Does Knockout of PGLYRP4 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
0
1,340
Knockout
PGLYRP4
response to chemicals
Retinal Pigment Epithelium Cell Line
Gene: PGLYRP4 (peptidoglycan recognition protein 4) Type: protein-coding Summary: Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitou...
Does Knockout of TSR1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
1
763
Knockout
TSR1
cell proliferation
Ewing's Sarcoma Cell Line
Gene: TSR1 (TSR1 ribosome maturation factor) Type: protein-coding Summary: Enables RNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA,...
Does Knockout of SCAP in Cancer Cell Line causally result in cell proliferation?
1
193
Knockout
SCAP
cell proliferation
Cancer Cell Line
Gene: SCAP (SREBF chaperone) Type: protein-coding Summary: This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi....
Does Knockout of C2orf81 in Monocytic Leukemia Cell Line causally result in cell proliferation?
0
80
Knockout
C2orf81
cell proliferation
Monocytic Leukemia Cell Line
Gene: C2orf81 (chromosome 2 open reading frame 81) Type: protein-coding Summary: Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontology: Pathways: UniProt:...
Does Knockout of STAB1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
0
2,396
Knockout
STAB1
response to chemicals
Chronic Myelogenous Leukemia Cell Line
Gene: STAB1 (stabilin 1) Type: protein-coding Summary: This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-l...
Does Knockout of CXXC4 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
0
1,339
Knockout
CXXC4
response to chemicals
Retinal Pigment Epithelium Cell Line
Gene: CXXC4 (CXXC finger protein 4) Type: protein-coding Summary: This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through int...
Does Knockout of DR1 in Endometrial Cancer Cell Line causally result in cell proliferation?
1
758
Knockout
DR1
cell proliferation
Endometrial Cancer Cell Line
Gene: DR1 (down-regulator of transcription 1) Type: protein-coding Summary: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its in...
Does Knockout of NPIPB7 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
0
2,430
Knockout
NPIPB7
response to virus
Cervical Adenocarcinoma Cell Line
Gene: NPIPB7 (nuclear pore complex interacting protein family member B7) Type: protein-coding Summary: Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontology: Pathways: UniProt: O75200 Entrez ID: 440350
Does Knockout of MIDN in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
1
1,658
Knockout
MIDN
cell proliferation
Colonic Adenocarcinoma Cell Line
Gene: MIDN (midnolin) Type: protein-coding Summary: Predicted to enable kinase binding activity. Predicted to be involved in negative regulation of glucokinase activity and negative regulation of insulin secretion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022] ...
Does Knockout of SCLT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
0
2,114
Knockout
SCLT1
cell proliferation
Primary Effusion Lymphoma Cell Line
Gene: SCLT1 (sodium channel and clathrin linker 1) Type: protein-coding Summary: This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also be...
Does Activation of HHEX in Hepatoma Cell Line causally result in response to virus?
1
1,210
Activation
HHEX
response to virus
Hepatoma Cell Line
Gene: HHEX (hematopoietically expressed homeobox) Type: protein-coding Summary: This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in h...
Does Knockout of MRPL27 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
1
1,311
Knockout
MRPL27
cell proliferation
Oral Squamous Cell Carcinoma Cell Line
Gene: MRPL27 (mitochondrial ribosomal protein L27) Type: protein-coding Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit....
Does Knockout of PDGFC in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
0
149
Knockout
PDGFC
cell proliferation
Chronic Myeloid Leukemia Cell Line
Gene: PDGFC (platelet derived growth factor C) Type: protein-coding Summary: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cys...
Does Knockout of RPS27A in Mammary Gland Tumor Cell Line causally result in cell proliferation?
1
220
Knockout
RPS27A
cell proliferation
Mammary Gland Tumor Cell Line
Gene: RPS27A (ribosomal protein S27a) Type: protein-coding Summary: Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fuse...
Does Knockout of DENND1B in Breast Cancer Cell Line causally result in cell proliferation?
0
235
Knockout
DENND1B
cell proliferation
Breast Cancer Cell Line
Gene: DENND1B (DENN domain containing 1B) Type: protein-coding Summary: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early ...
Does Knockout of SHOC2 in Cancer Cell Line causally result in cell proliferation?
0
193
Knockout
SHOC2
cell proliferation
Cancer Cell Line
Gene: SHOC2 (SHOC2 leucine rich repeat scaffold protein) Type: protein-coding Summary: This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transduce...
Does Knockout of OR8G2P in Lung Cancer Cell Line causally result in response to virus?
1
1,433
Knockout
OR8G2P
response to virus
Lung Cancer Cell Line
Gene: OR8G2P (olfactory receptor family 8 subfamily G member 2 pseudogene) Type: pseudo Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-pr...
Does Activation of HNRNPCL4 in T cell causally result in protein/peptide accumulation?
0
2,426
Activation
HNRNPCL4
protein/peptide accumulation
T cell
Gene: HNRNPCL4 (heterogeneous nuclear ribonucleoprotein C like 4) Type: protein-coding Summary: Predicted to enable RNA binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontology: MF: RNA binding, nucleic acid binding; CC: nucleus ...
Does Knockout of OR5D18 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
0
2,222
Knockout
OR5D18
response to chemicals
Diffuse Large B-cell Lymphoma Cell
Gene: OR5D18 (olfactory receptor family 5 subfamily D member 18) Type: protein-coding Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot...
Does Knockout of POP4 in Cancer Cell Line causally result in cell proliferation?
1
193
Knockout
POP4
cell proliferation
Cancer Cell Line
Gene: POP4 (POP4 ribonuclease P/MRP subunit) Type: protein-coding Summary: This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to t...
Does Knockout of MTHFR in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
1
1,789
Knockout
MTHFR
cell proliferation
Chronic Myeloid Leukemia Cell Line
Gene: MTHFR (methylenetetrahydrofolate reductase) Type: protein-coding Summary: The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences ...
Does Knockout of EYA1 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
0
1,631
Knockout
EYA1
response to chemicals
Non-Small Cell Lung Adenocarcinoma Cell Line
Gene: EYA1 (EYA transcriptional coactivator and phosphatase 1) Type: protein-coding Summary: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated w...
Does Knockout of BCL9 in Renal Cancer Cell Line causally result in cell proliferation?
0
319
Knockout
BCL9
cell proliferation
Renal Cancer Cell Line
Gene: BCL9 (BCL9 transcription coactivator) Type: protein-coding Summary: BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significa...
Does Knockout of ADAMTS20 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
0
1,461
Knockout
ADAMTS20
protein/peptide accumulation
Embryonic Kidney Cell Line
Gene: ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif 20) Type: protein-coding Summary: The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secrete...
Does Knockout of ACTR6 in Breast Cancer Cell Line causally result in cell proliferation?
1
235
Knockout
ACTR6
cell proliferation
Breast Cancer Cell Line
Gene: ACTR6 (actin related protein 6) Type: protein-coding Summary: Predicted to enable nucleosome binding activity. Predicted to be involved in histone exchange. Predicted to be located in nucleus. Predicted to be part of Swr1 complex. [provided by Alliance of Genome Resources, Apr 2022] Gene ...
Does Knockout of TP53RK in Medulloblastoma Cell Line causally result in cell proliferation?
1
408
Knockout
TP53RK
cell proliferation
Medulloblastoma Cell Line
Gene: TP53RK (TP53 regulating kinase) Type: protein-coding Summary: Enables p53 binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 4. [provided by Alliance ...
Does Knockout of DRAP1 in Melanoma Cell Line causally result in cell proliferation?
1
527
Knockout
DRAP1
cell proliferation
Melanoma Cell Line
Gene: DRAP1 (DR1 associated protein 1) Type: protein-coding Summary: Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly o...
Does Knockout of SCN10A in Lung Cancer Cell Line causally result in response to virus?
0
1,433
Knockout
SCN10A
response to virus
Lung Cancer Cell Line
Gene: SCN10A (sodium voltage-gated channel alpha subunit 10) Type: protein-coding Summary: The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with...
Does Knockout of FCGR1A in Hepatoma Cell Line causally result in cell proliferation?
0
1,206
Knockout
FCGR1A
cell proliferation
Hepatoma Cell Line
Gene: FCGR1A (Fc gamma receptor Ia) Type: protein-coding Summary: This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 200...
Does Activation of KIN in T cell causally result in protein/peptide accumulation?
0
2,425
Activation
KIN
protein/peptide accumulation
T cell
Gene: KIN (Kin17 DNA and RNA binding protein) Type: protein-coding Summary: The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of t...
Does Knockout of COA5 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
0
2,033
Knockout
COA5
response to virus
Cervical Adenocarcinoma Cell Line
Gene: COA5 (cytochrome c oxidase assembly factor 5) Type: protein-coding Summary: This gene encodes an ortholog of yeast Pet191, which in yeast is a subunit of a large oligomeric complex associated with the mitochondrial inner membrane, and required for the assembly of the cytochrome c oxidase complex. ...
Does Knockout of EMILIN3 in Gastric Cancer Cell Line causally result in cell proliferation?
0
787
Knockout
EMILIN3
cell proliferation
Gastric Cancer Cell Line
Gene: EMILIN3 (elastin microfibril interfacer 3) Type: protein-coding Summary: Enables identical protein binding activity. Part of collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontology: MF: extracellular matrix constituent conferring elasti...
Does Knockout of ODAM in Cervical Adenocarcinoma Cell Line causally result in response to virus?
0
2,430
Knockout
ODAM
response to virus
Cervical Adenocarcinoma Cell Line
Gene: ODAM (odontogenic, ameloblast associated) Type: protein-coding Summary: Involved in several processes, including positive regulation of GTPase activity; positive regulation of epithelial cell proliferation involved in wound healing; and positive regulation of macromolecule metabolic process. Locat...
Does Knockout of LEMD2 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
0
734
Knockout
LEMD2
cell proliferation
Large Cell Lung Cancer Cell Line
Gene: LEMD2 (LEM domain nuclear envelope protein 2) Type: protein-coding Summary: This gene encodes a LEM domain-containing transmembrane protein of the inner nuclear membrane. The protein is involved in nuclear structure organization and plays a role in cell signaling and differentiation. Mutations in ...
Does Knockout of CENPI in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
1
149
Knockout
CENPI
cell proliferation
Chronic Myeloid Leukemia Cell Line
Gene: CENPI (centromere protein I) Type: protein-coding Summary: This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein...
Does Knockout of DDX56 in Gastric Cancer Cell Line causally result in cell proliferation?
1
230
Knockout
DDX56
cell proliferation
Gastric Cancer Cell Line
Gene: DDX56 (DEAD-box helicase 56) Type: protein-coding Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alterati...
Does Knockout of IFT140 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
0
387
Knockout
IFT140
cell proliferation
Lung Adenocarcinoma Cell Line
Gene: IFT140 (intraflagellar transport 140) Type: protein-coding Summary: This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based senso...
Does Knockout of RAD9A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
1
1,789
Knockout
RAD9A
cell proliferation
Chronic Myeloid Leukemia Cell Line
Gene: RAD9A (RAD9 checkpoint clamp component A) Type: protein-coding Summary: This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contr...
Does Knockout of CR1L in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
0
1,340
Knockout
CR1L
response to chemicals
Retinal Pigment Epithelium Cell Line
Gene: CR1L (complement C3b/C4b receptor 1 like) Type: protein-coding Summary: Acts upstream of or within regulation of complement activation and regulation of complement-dependent cytotoxicity. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022] Gene Ontology: BP: T c...
Does Knockout of HNRNPH1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
1
334
Knockout
HNRNPH1
cell proliferation
Esophageal Squamous Cell Carcinoma Cell Line
Gene: HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1) Type: protein-coding Summary: This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins ...
Does Knockout of AKAP10 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
1
1,736
Knockout
AKAP10
response to chemicals
Colonic Adenocarcinoma Cell Line
Gene: AKAP10 (A-kinase anchoring protein 10) Type: protein-coding Summary: This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded pr...
Does Knockout of GTF2F1 in Cancer Cell Line causally result in cell proliferation?
1
193
Knockout
GTF2F1
cell proliferation
Cancer Cell Line
Gene: GTF2F1 (general transcription factor IIF subunit 1) Type: protein-coding Summary: Enables several functions, including RNA polymerase II general transcription initiation factor activity; phosphatase activator activity; and promoter-specific chromatin binding activity. Involved in several processes...
Does Knockout of MORN5 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
0
1,968
Knockout
MORN5
RNA accumulation
Monocytic Leukemia Cell Line
Gene: MORN5 (MORN repeat containing 5) Type: protein-coding Summary: Predicted to be located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025] Gene Ontology: CC: cell projection, cilium, motile cilium, sperm flagellum Pathways: UniProt: Q5VZ52 E...
Does Knockout of EED in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
1
1,032
Knockout
EED
cell proliferation
Chronic Myeloid Leukemia Cell Line
Gene: EED (embryonic ectoderm development) Type: protein-coding Summary: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. ...
Does Knockout of FBXO39 in Astrocytoma Cell Line causally result in cell proliferation?
0
904
Knockout
FBXO39
cell proliferation
Astrocytoma Cell Line
Gene: FBXO39 (F-box protein 39) Type: protein-coding Summary: Members of the F-box protein family, such as FBXO39, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin liga...
Does Knockout of FAM184B in Monocytic Leukemia Cell Line causally result in RNA accumulation?
0
1,968
Knockout
FAM184B
RNA accumulation
Monocytic Leukemia Cell Line
Gene: FAM184B (family with sequence similarity 184 member B) Type: protein-coding Summary: family with sequence similarity 184 member B Gene Ontology: Pathways: UniProt: Q9ULE4 Entrez ID: 27146