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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of POLR2F in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
POLR2F
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: POLR2F (RNA polymerase II, I and III subunit F)
Type: protein-coding
Summary: This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: DNA-templated transcription, tRNA transcription by RNA polymerase III, transcription by RNA polymerase I, transcription by RNA polymerase II; MF: DNA binding, DNA-directed RNA polymerase activity; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, RNA polymerase II, core complex, RNA polymerase III complex, cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: Abortive elongation of HIV-1 transcript in the absence of Tat, Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, B-WICH complex positively regulates rRNA expression, Cell Cycle, Chromosome Maintenance, Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , DNA Repair, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dual incision in TC-NER, ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, Eukaryotic Transcription Initiation, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene Silencing by RNA, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, HIV elongation arrest and recovery, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inhibition of DNA recombination at telomere, Innate Immune System, Late Phase of HIV Life Cycle, Metabolism of RNA, MicroRNA (miRNA) biogenesis, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, PIWI-interacting RNA (piRNA) biogenesis, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, Positive epigenetic regulation of rRNA expression, Processing of Capped Intron-Containing Pre-mRNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Telomere Maintenance, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by small RNAs, Viral Infection Pathways, Viral Messenger RNA Synthesis, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P61218
Entrez ID: 5435
|
Does Knockout of CUL4A in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
CUL4A
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CUL4A (cullin 4A)
Type: protein-coding
Summary: CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009].
Gene Ontology: BP: DNA damage response, DNA repair, G1/S transition of mitotic cell cycle, T cell activation, base-excision repair, AP site formation via deaminated base removal, cell population proliferation, cellular response to UV, developmental process, hemopoiesis, in utero embryonic development, intrinsic apoptotic signaling pathway, miRNA-mediated gene silencing by mRNA destabilization, negative regulation of granulocyte differentiation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination, regulation of DNA damage checkpoint, regulation of nucleotide-excision repair, regulation of protein metabolic process, rhythmic process, ribosome biogenesis, somatic stem cell population maintenance, spermatogenesis, type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: protein binding, ubiquitin ligase complex scaffold activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding; CC: Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, cullin-RING ubiquitin ligase complex, cytoplasm, nucleoplasm, nucleus
Pathways: DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Repair, DNA Repair Pathways Full Network, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Global Genome Nucleotide Excision Repair (GG-NER), Hippo-Merlin Signaling Dysregulation, Human immunodeficiency virus 1 infection - Homo sapiens (human), Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), Post-translational protein modification, Recognition of DNA damage by PCNA-containing replication complex, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q13619
Entrez ID: 8451
|
Does Knockout of TRAF7 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
TRAF7
|
cell proliferation
|
Bladder Carcinoma
|
Gene: TRAF7 (TNF receptor associated factor 7)
Type: protein-coding
Summary: Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: apoptotic process, canonical NF-kappaB signal transduction, positive regulation of MAPK cascade, positive regulation of apoptotic signaling pathway, positive regulation of neuron apoptotic process, positive regulation of protein metabolic process, positive regulation of ubiquitin-dependent protein catabolic process, protein K29-linked ubiquitination, protein ubiquitination, regulation of ERK1 and ERK2 cascade, regulation of transcription by RNA polymerase II; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytoplasmic vesicle, nucleus, plasma membrane, ubiquitin ligase complex
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, TNFalpha
UniProt: Q6Q0C0
Entrez ID: 84231
|
Does Knockout of LEMD3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
LEMD3
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: LEMD3 (LEM domain containing 3)
Type: protein-coding
Summary: This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009].
Gene Ontology: BP: negative regulation of BMP signaling pathway, negative regulation of activin receptor signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway; MF: DNA binding, U1 snRNP binding, nucleic acid binding, protein binding; CC: membrane, nuclear envelope, nuclear inner membrane, nuclear membrane, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Depolymerization of the Nuclear Lamina, Envelope proteins and their potential roles in EDMD physiopathology, Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOD GTPase cycle, RHOG GTPase cycle, RND1 GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9Y2U8
Entrez ID: 23592
|
Does Knockout of RAVER1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
RAVER1
|
cell proliferation
|
Cancer Cell Line
|
Gene: RAVER1 (ribonucleoprotein, PTB binding 1)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, nucleic acid binding, protein binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q8IY67
Entrez ID: 125950
|
Does Knockout of ALG13 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
ALG13
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: ALG13 (ALG13 UDP-N-acetylglucosaminyltransferase subunit)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, proteolysis; MF: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity, catalytic activity, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, glycosyltransferase activity, hexosyltransferase activity, hydrolase activity, peptidase activity, protein binding, transferase activity; CC: UDP-N-acetylglucosamine transferase complex, cytoplasm, cytoplasmic side of endoplasmic reticulum membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: N-Glycan biosynthesis - Homo sapiens (human), Various types of N-glycan biosynthesis - Homo sapiens (human), dolichyl-diphosphooligosaccharide biosynthesis
UniProt: Q9NP73
Entrez ID: 79868
|
Does Knockout of CISD1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
CISD1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CISD1 (CDGSH iron sulfur domain 1)
Type: protein-coding
Summary: This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: intracellular iron ion homeostasis, protein maturation, regulation of autophagy, regulation of cellular respiration; MF: 2 iron, 2 sulfur cluster binding, L-cysteine transaminase activity, identical protein binding, iron-sulfur cluster binding, metal ion binding, protein homodimerization activity, pyridoxal phosphate binding, transferase activity; CC: membrane, mitochondrial outer membrane, mitochondrion
Pathways: Adipogenesis
UniProt: Q9NZ45
Entrez ID: 55847
|
Does Knockout of SPAG16 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
SPAG16
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: SPAG16 (sperm associated antigen 16)
Type: protein-coding
Summary: Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008].
Gene Ontology: BP: axoneme assembly, cell projection organization, cerebrospinal fluid circulation, cilium assembly, mucociliary clearance, sperm axoneme assembly; CC: axonemal central apparatus, axoneme, cell projection, cilium, cytoplasm, cytoskeleton, extracellular region, motile cilium, sperm flagellum
Pathways:
UniProt: Q8N0X2
Entrez ID: 79582
|
Does Knockout of RUBCN in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
RUBCN
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RUBCN (rubicon autophagy regulator)
Type: protein-coding
Summary: The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: autophagy, endocytosis, immune system process, multivesicular body sorting pathway, negative regulation of autophagosome maturation, negative regulation of autophagy, negative regulation of endocytosis, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, phagocytosis; MF: phosphatidylinositol 3-kinase inhibitor activity, phosphatidylinositol phosphate binding, protein binding; CC: Golgi apparatus, cytosol, early endosome, endosome, late endosome, lysosome, nucleoplasm
Pathways: Autophagy - animal - Homo sapiens (human)
UniProt: Q92622
Entrez ID: 9711
|
Does Knockout of SUSD2 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
SUSD2
|
cell proliferation
|
Bladder Carcinoma
|
Gene: SUSD2 (sushi domain containing 2)
Type: protein-coding
Summary: Involved in negative regulation of cell cycle G1/S phase transition and negative regulation of cell division. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of cell cycle G1/S phase transition, negative regulation of cell division; CC: extracellular exosome, extracellular space, membrane, plasma membrane
Pathways:
UniProt: Q9UGT4
Entrez ID: 56241
|
Does Knockout of GCN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
GCN1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: GCN1 (GCN1 activator of EIF2AK4)
Type: protein-coding
Summary: Enables RNA binding activity and cadherin binding activity. Predicted to be involved in cellular response to leucine starvation and positive regulation of transcription from RNA polymerase II promoter in response to stress. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: GCN2-mediated signaling, cellular response to amino acid starvation, protein K6-linked ubiquitination, protein-RNA covalent cross-linking repair, regulation of translation, rescue of stalled ribosome, translational elongation, ubiquitin-dependent protein catabolic process; MF: RNA binding, cadherin binding, molecular adaptor activity, protein kinase regulator activity, protein serine/threonine kinase activator activity, stalled ribosome sensor activity, translation factor activity, RNA binding, ubiquitin-protein transferase regulator activity; CC: cytoplasm, cytosol, cytosolic ribosome, membrane, ribosome
Pathways: Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Response of EIF2AK4 (GCN2) to amino acid deficiency
UniProt: Q92616
Entrez ID: 10985
|
Does Knockout of EIF3C in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
EIF3C
|
cell proliferation
|
Cancer Cell Line
|
Gene: EIF3C (eukaryotic translation initiation factor 3 subunit C)
Type: protein-coding
Summary: Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, positive regulation of translation, translation, translational initiation; MF: RNA binding, protein binding, ribosome binding, translation initiation factor activity, translation initiation factor binding; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: Q99613
Entrez ID: 8663
|
Does Knockout of RPL13 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
RPL13
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: RPL13 (ribosomal protein L13)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L13E family of ribosomal proteins. It is located in the cytoplasm. This gene is expressed at significantly higher levels in benign breast lesions than in breast carcinomas. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: blastocyst development, bone development, cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, membrane, nucleolus, nucleus, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P26373
Entrez ID: 6137
|
Does Knockout of FIS1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
FIS1
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: FIS1 (fission, mitochondrial 1)
Type: protein-coding
Summary: The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]
Gene Ontology: BP: apoptotic process, cellular response to glucose stimulus, cellular response to lipid, cellular response to peptide, cellular response to toxic substance, mitochondrial fission, mitochondrial fragmentation involved in apoptotic process, mitochondrion organization, negative regulation of ATP metabolic process, negative regulation of fatty acid transport, peroxisome fission, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of mitochondrial fission, positive regulation of neuron apoptotic process, protein targeting to mitochondrion, response to endoplasmic reticulum stress, response to flavonoid, response to fluoride, response to hypobaric hypoxia, response to muscle activity, response to nutrient levels; MF: identical protein binding, lipid binding, molecular adaptor activity, protein binding; CC: cytosol, membrane, mitochondrial outer membrane, mitochondrion, peroxisomal membrane, peroxisome, protein-containing complex
Pathways: CAMKK2 Pathway, Class I peroxisomal membrane protein import, Mitophagy - animal - Homo sapiens (human), Protein localization
UniProt: Q9Y3D6
Entrez ID: 51024
|
Does Knockout of PIGM in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
PIGM
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: PIGM (phosphatidylinositol glycan anchor biosynthesis class M)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: GPI anchor biosynthetic process; MF: GPI mannosyltransferase activity, alpha-1,4-mannosyltransferase activity, dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity, glycosyltransferase activity, mannosyltransferase activity, protein binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, glycosylphosphatidylinositol-mannosyltransferase I complex, membrane
Pathways: 3q29 copy number variation syndrome, Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Homo sapiens (human), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Synthesis of glycosylphosphatidylinositol (GPI)
UniProt: Q9H3S5
Entrez ID: 93183
|
Does Knockout of TMEM65 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
TMEM65
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: TMEM65 (transmembrane protein 65)
Type: protein-coding
Summary: Predicted to be involved in cardiac ventricle development and regulation of cardiac conduction. Located in intercalated disc; mitochondrial inner membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cardiac conduction, cardiac ventricle development, regulation of cardiac conduction; CC: intercalated disc, membrane, mitochondrial inner membrane, mitochondrion, nucleolus, plasma membrane
Pathways:
UniProt: Q6PI78
Entrez ID: 157378
|
Does Knockout of TJP3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
TJP3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: TJP3 (tight junction protein 3)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012].
Gene Ontology: BP: cell-cell adhesion, cell-cell junction organization, establishment of endothelial intestinal barrier, maintenance of blood-brain barrier, positive regulation of blood-brain barrier permeability, protein localization to cell-cell junction; MF: cell adhesion molecule binding, protein binding; CC: anchoring junction, bicellular tight junction, cell junction, cell-cell junction, membrane, nucleoplasm, nucleus, plasma membrane, tight junction
Pathways: 1q21.1 copy number variation syndrome, Tight junction - Homo sapiens (human)
UniProt: O95049
Entrez ID: 27134
|
Does Knockout of RAB5C in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
RAB5C
|
cell proliferation
|
Bladder Carcinoma
|
Gene: RAB5C (RAB5C, member RAS oncogene family)
Type: protein-coding
Summary: Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: endocytosis, endosomal transport, endosome organization, intracellular protein transport, plasma membrane to endosome transport, protein transport, regulation of endocytosis; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: azurophil granule membrane, early endosome, early endosome membrane, endocytic vesicle, endomembrane system, endosome, extracellular exosome, lipid droplet, lysosomal membrane, melanosome, membrane, plasma membrane
Pathways: Amoebiasis - Homo sapiens (human), Clathrin-mediated endocytosis, Disease, Endocytosis - Homo sapiens (human), Golgi Associated Vesicle Biogenesis, Immune System, Infectious disease, Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells, Innate Immune System, Membrane Trafficking, Metabolism of proteins, Neutrophil degranulation, Phagosome - Homo sapiens (human), Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Ras signaling, Ras signaling pathway - Homo sapiens (human), Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) attachment and entry, Salmonella infection - Homo sapiens (human), TBC/RABGAPs, Tuberculosis - Homo sapiens (human), Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, Viral Infection Pathways, trans-Golgi Network Vesicle Budding
UniProt: P51148
Entrez ID: 5878
|
Does Knockout of UROD in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
UROD
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: UROD (uroporphyrinogen decarboxylase)
Type: protein-coding
Summary: This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010].
Gene Ontology: BP: heme A biosynthetic process, heme B biosynthetic process, heme O biosynthetic process, heme biosynthetic process, heme metabolic process, porphyrin-containing compound biosynthetic process, porphyrin-containing compound catabolic process, porphyrin-containing compound metabolic process, protoporphyrinogen IX biosynthetic process; MF: carboxy-lyase activity, lyase activity, protein binding, uroporphyrinogen decarboxylase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Acute Intermittent Porphyria, Congenital Erythropoietic Porphyria (CEP) or Gunther Disease, Heme Biosynthesis, Heme biosynthesis, Hereditary Coproporphyria (HCP), Metabolism, Metabolism of porphyrins, Porphyria Variegata (PV), Porphyrin Metabolism, Porphyrin and chlorophyll metabolism - Homo sapiens (human), heme biosynthesis, heme biosynthesis from uroporphyrinogen-III I, hemoglobins chaperone
UniProt: P06132
Entrez ID: 7389
|
Does Knockout of S100A11 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
S100A11
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: S100A11 (S100 calcium binding protein A11)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell-cell adhesion, negative regulation of DNA replication, negative regulation of cell population proliferation, positive regulation of smooth muscle cell migration, regulation of cell population proliferation, signal transduction; MF: S100 protein binding, cadherin binding involved in cell-cell adhesion, calcium ion binding, calcium-dependent protein binding, metal ion binding, protein binding, protein homodimerization activity; CC: adherens junction, cytoplasm, extracellular exosome, extracellular region, extracellular space, nucleus, ruffle, secretory granule lumen
Pathways: EGFR1, Immune System, Innate Immune System, Neutrophil degranulation
UniProt: P31949
Entrez ID: 6282
|
Does Knockout of NCKAP1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
NCKAP1
|
cell proliferation
|
Cancer Cell Line
|
Gene: NCKAP1 (NCK associated protein 1)
Type: protein-coding
Summary: Contributes to small GTPase binding activity. Involved in Rac protein signal transduction; positive regulation of Arp2/3 complex-mediated actin nucleation; and positive regulation of lamellipodium assembly. Located in extracellular exosome and focal adhesion. Part of SCAR complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Rac protein signal transduction, apical protein localization, apoptotic process, basal protein localization, cell migration, cell migration involved in gastrulation, cell morphogenesis, cell projection assembly, central nervous system development, cortical actin cytoskeleton organization, embryonic body morphogenesis, embryonic foregut morphogenesis, embryonic heart tube development, endoderm development, establishment or maintenance of actin cytoskeleton polarity, in utero embryonic development, lamellipodium assembly, mesodermal cell migration, neural tube closure, neuron projection morphogenesis, notochord development, notochord morphogenesis, paraxial mesoderm development, paraxial mesoderm morphogenesis, positive regulation of Arp2/3 complex-mediated actin nucleation, positive regulation of actin filament polymerization, positive regulation of lamellipodium assembly, protein stabilization, regulation of protein localization, somitogenesis, zygotic determination of anterior/posterior axis, embryo; MF: protein binding, small GTPase binding; CC: SCAR complex, cell projection, cytosol, extracellular exosome, filamentous actin, focal adhesion, lamellipodium, lamellipodium membrane, membrane, plasma membrane, postsynapse, ruffle
Pathways: Disease, E-cadherin signaling in the nascent adherens junction, ErbB1 downstream signaling, Exercise-induced Circadian Regulation, FCGR3A-mediated phagocytosis, Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania phagocytosis, PDGFR-beta signaling pathway, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), RAC1 GTPase cycle, RAC1 signaling pathway, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Stabilization and expansion of the E-cadherin adherens junction, VEGFA-VEGFR2 Pathway, y branching of actin filaments
UniProt: Q9Y2A7
Entrez ID: 10787
|
Does Knockout of ZGRF1 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
ZGRF1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: ZGRF1 (zinc finger GRF-type containing 1)
Type: protein-coding
Summary: The encoded protein contains GRF zinc finger (zf-GRF) and transmembrane domains. GRF zinc fingers are found in a number of DNA-binding proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2017].
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair, recombinational repair; MF: 5'-3' DNA helicase activity, ATP binding, helicase activity, hydrolase activity, isomerase activity, metal ion binding, nucleotide binding, protein binding, zinc ion binding; CC: nucleus, site of double-strand break
Pathways:
UniProt: Q86YA3
Entrez ID: 55345
|
Does Knockout of UST in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
UST
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: UST (uronyl 2-sulfotransferase)
Type: protein-coding
Summary: Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: dermatan sulfate proteoglycan biosynthetic process, establishment of cell polarity, regulation of axonogenesis; MF: 3'-phosphoadenosine 5'-phosphosulfate binding, chondroitin 2-sulfotransferase activity, dermatan 2-sulfotransferase activity, sulfotransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: CS-GAG biosynthesis, Chondroitin sulfate/dermatan sulfate metabolism, DS-GAG biosynthesis, Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human), Glycosaminoglycan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, chondroitin sulfate biosynthesis, chondroitin sulfate biosynthesis (late stages), dermatan sulfate biosynthesis, dermatan sulfate biosynthesis (late stages)
UniProt: Q9Y2C2
Entrez ID: 10090
|
Does Knockout of RAB7A in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
RAB7A
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: RAB7A (RAB7A, member RAS oncogene family)
Type: protein-coding
Summary: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: autophagosome assembly, autophagy, bone resorption, early endosome to late endosome transport, endocytosis, endosome to lysosome transport, endosome to plasma membrane protein transport, epidermal growth factor catabolic process, establishment of vesicle localization, lipid catabolic process, lipid metabolic process, lipophagy, negative regulation of exosomal secretion, negative regulation of intralumenal vesicle formation, neurotransmitter receptor transport, postsynaptic endosome to lysosome, phagosome acidification, phagosome maturation, phagosome-lysosome fusion, positive regulation of exosomal secretion, positive regulation of protein catabolic process, positive regulation of viral process, protein localization to lysosome, protein targeting to lysosome, protein to membrane docking, protein transport, response to bacterium, retrograde transport, endosome to Golgi, synaptic vesicle recycling via endosome, vesicle-mediated transport in synapse, viral release from host cell; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding, retromer complex binding, small GTPase binding; CC: Golgi apparatus, alveolar lamellar body, autophagosome membrane, bounding membrane of organelle, cytoplasm, cytoplasmic vesicle, cytosol, endosome, endosome membrane, extracellular exosome, glutamatergic synapse, late endosome, late endosome membrane, lipid droplet, lysosomal membrane, lysosome, melanosome membrane, membrane, mitochondrial membrane, mitochondrion, phagocytic vesicle, phagocytic vesicle membrane, phagophore assembly site membrane, plasma membrane, presynaptic endosome, retromer complex, secretory granule membrane, synaptic vesicle membrane
Pathways: Adaptive Immune System, Amoebiasis - Homo sapiens (human), Autophagy - animal - Homo sapiens (human), Autosomal recessive Osteopetrosis pathways, Bacterial Infection Pathways, CDC42 GTPase cycle, Disease, Ebola Virus Pathway on Host, Endocytosis - Homo sapiens (human), IL12-mediated signaling events, IL8- and CXCR2-mediated signaling events, Immune System, Infection with Mycobacterium tuberculosis, Infectious disease, Innate Immune System, Intracellular trafficking proteins involved in CMT neuropathy, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitophagy - animal - Homo sapiens (human), Neutrophil degranulation, Phagosome - Homo sapiens (human), Post-translational protein modification, Posttranslational regulation of adherens junction stability and dissassembly, Prevention of phagosomal-lysosomal fusion, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, RHOH GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, Rab regulation of trafficking, Response of Mtb to phagocytosis, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Suppression of autophagy, Suppression of phagosomal maturation, TBC/RABGAPs, Tuberculosis - Homo sapiens (human), Vesicle-mediated transport
UniProt: P51149
Entrez ID: 7879
|
Does Activation of KIF3A in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
KIF3A
|
response to virus
|
Hepatoma Cell Line
|
Gene: KIF3A (kinesin family member 3A)
Type: protein-coding
Summary: Enables protein phosphatase binding activity; small GTPase binding activity; and spectrin binding activity. Involved in protein localization to cell junction and protein transport. Located in centriole and centrosome. Part of kinesin II complex. Colocalizes with spindle microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: anterograde axonal transport, cell projection organization, centriole-centriole cohesion, cilium assembly, microtubule anchoring at centrosome, microtubule-based movement, organelle organization, plus-end-directed vesicle transport along microtubule, protein localization to cell junction, protein transport, transport along microtubule; MF: ATP binding, ATP hydrolysis activity, cytoskeletal protein binding, microtubule binding, microtubule motor activity, nucleotide binding, plus-end-directed microtubule motor activity, protein binding, protein phosphatase binding, protein-containing complex binding, small GTPase binding, spectrin binding; CC: axon cytoplasm, cell projection, centriole, centrosome, ciliary tip, cilium, cytoplasm, cytoskeleton, cytosol, extracellular exosome, kinesin II complex, kinesin complex, microtubule, microtubule cytoskeleton, spindle microtubule
Pathways: Activation of SMO, Adaptive Immune System, COPI-dependent Golgi-to-ER retrograde traffic, Cilium Assembly, Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, Factors involved in megakaryocyte development and platelet production, Genes related to primary cilium development (based on CRISPR), Golgi-to-ER retrograde transport, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog Signaling Pathway, Hedgehog signaling events mediated by Gli proteins, Hedgehog signaling pathway - Homo sapiens (human), Hemostasis, Immune System, Insulin Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, MHC class II antigen presentation, Membrane Trafficking, Organelle biogenesis and maintenance, Signal Transduction, Signaling by Hedgehog, Translocation of SLC2A4 (GLUT4) to the plasma membrane, Vesicle-mediated transport
UniProt: Q9Y496
Entrez ID: 11127
|
Does Knockout of PSD in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
PSD
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PSD (pleckstrin and Sec7 domain containing)
Type: protein-coding
Summary: This gene encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: neuron projection development, regulation of ARF protein signal transduction, signal transduction; MF: guanyl-nucleotide exchange factor activity, phospholipid binding, protein binding; CC: cell projection, cleavage furrow, dendritic spine, membrane, plasma membrane, postsynaptic density, postsynaptic density, intracellular component, ruffle membrane
Pathways: Endocytosis - Homo sapiens (human)
UniProt: A5PKW4
Entrez ID: 5662
|
Does Knockout of GJC3 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
GJC3
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: GJC3 (gap junction protein gamma 3)
Type: protein-coding
Summary: This gene encodes a gap junction protein. The encoded protein, also known as a connexin, plays a role in formation of gap junctions, which provide direct connections between neighboring cells. Mutations in this gene have been reported to be associated with nonsyndromic hearing loss.[provided by RefSeq, Feb 2010].
Gene Ontology: BP: AV node cell to bundle of His cell communication by electrical coupling, cell communication, cell-cell signaling, myelination, sensory perception of sound, transmembrane transport; MF: gap junction channel activity, gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling, identical protein binding, protein binding; CC: anchoring junction, connexin complex, gap junction, membrane, myelin sheath, plasma membrane
Pathways:
UniProt: Q8NFK1
Entrez ID: 349149
|
Does Knockout of NAA30 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 1
| 1,340
|
Knockout
|
NAA30
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit)
Type: protein-coding
Summary: Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal peptidyl-methionine acetylation. Located in cytosol and nucleus. Part of NatC complex. Colocalizes with polysome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic translation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein stabilization; MF: acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, protein N-terminal-methionine acetyltransferase activity, protein binding, protein-N-terminal amino-acid acetyltransferase activity, transferase activity; CC: NatC complex, cytoplasm, cytosol, nucleus
Pathways: Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metapathway biotransformation Phase I and II, Retrograde transport at the Trans-Golgi-Network, Vesicle-mediated transport
UniProt: Q147X3
Entrez ID: 122830
|
Does Knockout of MRPL10 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
MRPL10
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MRPL10 (mitochondrial ribosomal protein L10)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q7Z7H8
Entrez ID: 124995
|
Does Activation of THBS3 in T cell causally result in protein/peptide accumulation?
| 1
| 2,426
|
Activation
|
THBS3
|
protein/peptide accumulation
|
T cell
|
Gene: THBS3 (thrombospondin 3)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: bone trabecula formation, cell adhesion, cell-matrix adhesion, growth plate cartilage development, ossification involved in bone maturation; MF: calcium ion binding, extracellular matrix structural constituent, heparin binding, protein binding; CC: extracellular matrix, extracellular region, perinuclear region of cytoplasm
Pathways: ECM-receptor interaction - Homo sapiens (human), Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Inflammatory Response Pathway, Malaria - Homo sapiens (human), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Phagosome - Homo sapiens (human), Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases
UniProt: P49746
Entrez ID: 7059
|
Does Activation of PDCD2 in Hepatoma Cell Line causally result in response to virus?
| 0
| 1,210
|
Activation
|
PDCD2
|
response to virus
|
Hepatoma Cell Line
|
Gene: PDCD2 (programmed cell death 2)
Type: protein-coding
Summary: This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: apoptotic process, positive regulation of apoptotic process, positive regulation of hematopoietic stem cell proliferation, programmed cell death, regulation of hematopoietic progenitor cell differentiation; MF: DNA binding, enzyme binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, extracellular exosome, nucleus
Pathways: TNFalpha
UniProt: Q16342
Entrez ID: 5134
|
Does Knockout of UCKL1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
UCKL1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: UCKL1 (uridine-cytidine kinase 1 like 1)
Type: protein-coding
Summary: The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: CMP biosynthetic process, CTP salvage, UMP salvage, carbohydrate derivative biosynthetic process, nucleobase-containing compound biosynthetic process, nucleobase-containing small molecule metabolic process, pyrimidine nucleoside salvage, pyrimidine-containing compound salvage; MF: ATP binding, cytidine kinase activity, kinase activity, nucleotide binding, protein binding, transferase activity, uridine kinase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Beta Ureidopropionase Deficiency, Dihydropyrimidinase Deficiency, Drug metabolism - other enzymes - Homo sapiens (human), MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy), Metabolism, Metabolism of nucleotides, Nucleotide salvage, Pyrimidine Metabolism, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), Pyrimidine salvage, UMP Synthase Deiciency (Orotic Aciduria), pyrimidine ribonucleosides salvage I
UniProt: Q9NWZ5
Entrez ID: 54963
|
Does Knockout of CTPS2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
CTPS2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: CTPS2 (CTP synthase 2)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: 'de novo' CTP biosynthetic process, CTP biosynthetic process, pyrimidine nucleobase biosynthetic process, pyrimidine nucleotide biosynthetic process, pyrimidine nucleotide metabolic process, small molecule metabolic process; MF: ATP binding, CTP synthase activity, identical protein binding, ligase activity, nucleotide binding, protein binding; CC: cytoophidium, cytoplasm, cytosol, mitochondrion, nucleus
Pathways: Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), UTP and CTP <i>de novo</i> biosynthesis, UTP and CTP dephosphorylation I, UTP and CTP dephosphorylation II, superpathway of pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, superpathway of pyrimidine ribonucleotides <i>de novo</i> biosynthesis
UniProt: Q9NRF8
Entrez ID: 56474
|
Does Knockout of UNC45A in Lung Cancer Cell Line causally result in response to radiation?
| 1
| 1,952
|
Knockout
|
UNC45A
|
response to radiation
|
Lung Cancer Cell Line
|
Gene: UNC45A (unc-45 myosin chaperone A)
Type: protein-coding
Summary: This gene encodes a regulatory component of the progesterone receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the progesterone receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of myosin during development of muscle cells. [provided by RefSeq, Sep 2018].
Gene Ontology: BP: cell differentiation, muscle organ development, protein folding; MF: Hsp90 protein binding, cadherin binding, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, nuclear speck, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q9H3U1
Entrez ID: 55898
|
Does Knockout of PCDH17 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
PCDH17
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PCDH17 (protocadherin 17)
Type: protein-coding
Summary: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adult behavior, cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of synaptic transmission, presynaptic active zone assembly, regulation of synaptic vesicle clustering, synaptic membrane adhesion; MF: calcium ion binding, cell adhesion molecule binding, protein binding; CC: GABA-ergic synapse, glutamatergic synapse, membrane, plasma membrane, postsynaptic membrane, presynaptic membrane
Pathways:
UniProt: O14917
Entrez ID: 27253
|
Does Knockout of DCLRE1C in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
DCLRE1C
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DCLRE1C (DNA cross-link repair 1C)
Type: protein-coding
Summary: This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: B cell differentiation, DNA damage response, DNA metabolic process, DNA recombination, DNA repair, V(D)J recombination, adaptive immune response, chromosome organization, double-strand break repair, double-strand break repair via nonhomologous end joining, immune system process, interstrand cross-link repair, response to ionizing radiation, telomere maintenance; MF: 5'-3' DNA exonuclease activity, 5'-3' exonuclease activity, damaged DNA binding, endonuclease activity, exonuclease activity, hydrolase activity, nuclease activity, protein binding, single-stranded DNA endodeoxyribonuclease activity; CC: Golgi apparatus, nonhomologous end joining complex, nucleoplasm, nucleus
Pathways: ATM Signaling Network in Development and Disease, ATM pathway, DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, DNA-PK pathway in nonhomologous end joining, Non-homologous end joining, Non-homologous end-joining - Homo sapiens (human), Nonhomologous End-Joining (NHEJ), Primary immunodeficiency - Homo sapiens (human)
UniProt: Q96SD1
Entrez ID: 64421
|
Does Knockout of PEX11A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
PEX11A
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PEX11A (peroxisomal biogenesis factor 11 alpha)
Type: protein-coding
Summary: This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: brown fat cell differentiation, peroxisome fission, peroxisome membrane biogenesis, peroxisome organization, regulation of peroxisome size, signal transduction; MF: protein binding, protein homodimerization activity; CC: membrane, peroxisomal membrane, peroxisome, protein-containing complex
Pathways: Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, Peroxisome - Homo sapiens (human), Regulation of lipid metabolism by PPARalpha
UniProt: O75192
Entrez ID: 8800
|
Does Knockout of MYO1D in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
MYO1D
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MYO1D (myosin ID)
Type: protein-coding
Summary: Enables protein domain specific binding activity. Predicted to be involved in actin filament organization; early endosome to recycling endosome transport; and vesicle transport along actin filament. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin filament organization, actin filament-based movement, cellular localization, early endosome to recycling endosome transport, endocytosis, protein transport; MF: ATP binding, actin binding, actin filament binding, calcium-dependent protein binding, calmodulin binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding, protein binding, protein domain specific binding; CC: actin cytoskeleton, apical dendrite, axolemma, axon, basolateral plasma membrane, brush border, cell cortex, cell projection, cytoplasm, cytoplasmic vesicle, dendrite, early endosome, endosome, extracellular exosome, microvillus, myelin sheath, myosin complex, neuron projection, neuronal cell body, perikaryon, plasma membrane
Pathways: Pathogenic Escherichia coli infection - Homo sapiens (human)
UniProt: O94832
Entrez ID: 4642
|
Does Activation of KCNE3 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
KCNE3
|
protein/peptide accumulation
|
T cell
|
Gene: KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3)
Type: protein-coding
Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: intracellular chloride ion homeostasis, membrane repolarization during action potential, membrane repolarization during ventricular cardiac muscle cell action potential, monoatomic ion transport, negative regulation of delayed rectifier potassium channel activity, negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential, negative regulation of potassium ion export across plasma membrane, potassium ion export across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of heart rate by cardiac conduction, regulation of potassium ion transport, regulation of ventricular cardiac muscle cell membrane repolarization, sodium ion transport, ventricular cardiac muscle cell action potential; MF: delayed rectifier potassium channel activity, potassium channel regulator activity, protein binding, transmembrane transporter binding, voltage-gated potassium channel activity, voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; CC: basolateral part of cell, cell projection, cytoplasm, dendrite, membrane, membrane raft, neuronal cell body membrane, perikaryon, plasma membrane, vesicle, voltage-gated potassium channel complex
Pathways: Cardiac conduction, Muscle contraction, Phase 2 - plateau phase, Phase 3 - rapid repolarisation, Protein digestion and absorption - Homo sapiens (human), TYROBP causal network in microglia
UniProt: Q9Y6H6
Entrez ID: 10008
|
Does Knockout of IGLL5 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
IGLL5
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: IGLL5 (immunoglobulin lambda like polypeptide 5)
Type: protein-coding
Summary: This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Gene Ontology: CC: IgG immunoglobulin complex, extracellular exosome, extracellular region
Pathways:
UniProt: B9A064
Entrez ID: 100423062
|
Does Knockout of L3MBTL1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
L3MBTL1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1)
Type: protein-coding
Summary: This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].
Gene Ontology: BP: chromatin organization, constitutive heterochromatin formation, hemopoiesis, heterochromatin formation, negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of cell cycle, regulation of macromolecule metabolic process, regulation of megakaryocyte differentiation, regulation of mitotic nuclear division, regulation of primary metabolic process; MF: SAM domain binding, chromatin binding, histone H1 reader activity, histone H4K20me2 reader activity, histone binding, identical protein binding, metal ion binding, nucleosome binding, protein binding, zinc ion binding; CC: chromatin, chromatin lock complex, condensed chromosome, nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Transcriptional Regulation by TP53
UniProt: Q9Y468
Entrez ID: 26013
|
Does Knockout of GPN1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
GPN1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: GPN1 (GPN-loop GTPase 1)
Type: protein-coding
Summary: This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009].
Gene Ontology: MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q9HCN4
Entrez ID: 11321
|
Does Knockout of SNUPN in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
SNUPN
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: SNUPN (snurportin 1)
Type: protein-coding
Summary: The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA import into nucleus, cytoskeleton organization, protein complex oligomerization, protein import into nucleus, protein tetramerization, snRNA import into nucleus; MF: RNA binding, RNA cap binding, nuclear import signal receptor activity, protein binding; CC: NLS-dependent protein nuclear import complex, cytoplasm, cytosol, nuclear pore, nucleoplasm, nucleus, plasma membrane
Pathways: Metabolism of RNA, Metabolism of non-coding RNA, RNA transport - Homo sapiens (human), snRNP Assembly
UniProt: O95149
Entrez ID: 10073
|
Does Knockout of CTNNBL1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
CTNNBL1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: CTNNBL1 (catenin beta like 1)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: RNA splicing, adaptive immune response, gene expression, immune system process, mRNA processing, mRNA splicing, via spliceosome, positive regulation of apoptotic process, somatic diversification of immunoglobulins; MF: enzyme binding, protein binding; CC: Prp19 complex, centrosome, cytoplasm, cytosol, membrane, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8WYA6
Entrez ID: 56259
|
Does Knockout of GTF3C5 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
GTF3C5
|
cell proliferation
|
Cancer Cell Line
|
Gene: GTF3C5 (general transcription factor IIIC subunit 5)
Type: protein-coding
Summary: Predicted to contribute to DNA binding activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and tRNA transcription by RNA polymerase III. Predicted to act upstream of or within skeletal muscle cell differentiation. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 5S class rRNA transcription by RNA polymerase III, skeletal muscle cell differentiation, tRNA transcription by RNA polymerase III, transcription by RNA polymerase III, transcription initiation at RNA polymerase III promoter; MF: DNA binding, RNA polymerase III general transcription initiation factor activity, RNA polymerase III type 1 promoter sequence-specific DNA binding, RNA polymerase III type 2 promoter sequence-specific DNA binding, protein binding; CC: nucleoplasm, nucleus, transcription factor TFIIIC complex
Pathways: Gene expression (Transcription), RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, rna polymerase iii transcription
UniProt: Q9Y5Q8
Entrez ID: 9328
|
Does Knockout of IL24 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
IL24
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: IL24 (interleukin 24)
Type: protein-coding
Summary: This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, cellular response to interleukin-4, cellular response to lipopolysaccharide, immune response, negative regulation of cell migration, negative regulation of cell population proliferation, positive regulation of cell population proliferation, signal transduction; MF: cytokine activity, protein binding; CC: extracellular region, extracellular space
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), IL23-mediated signaling events, Immune System, Interleukin-20 family signaling, JAK-STAT signaling pathway - Homo sapiens (human), Senescence and Autophagy in Cancer, Signaling by Interleukins, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: Q13007
Entrez ID: 11009
|
Does Knockout of YBX1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
YBX1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: YBX1 (Y-box binding protein 1)
Type: protein-coding
Summary: This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: CRD-mediated mRNA stabilization, RNA splicing, RNA transport, cellular response to interleukin-7, embryonic morphogenesis, epidermis development, in utero embryonic development, mRNA processing, mRNA stabilization, miRNA transport, negative regulation of cellular senescence, negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, negative regulation of striated muscle cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of translation, positive regulation of cell division, positive regulation of cytoplasmic translation, positive regulation of transcription by RNA polymerase II, protein localization to cytoplasmic stress granule, regulation of DNA-templated transcription, regulation of gene expression, tRNA transport; MF: C5-methylcytidine-containing RNA reader activity, DNA binding, GTPase binding, RNA binding, chromatin binding, double-stranded DNA binding, mRNA binding, miRNA binding, nucleic acid binding, protein binding, sequence-specific double-stranded DNA binding, single-stranded DNA binding; CC: CRD-mediated mRNA stability complex, P-body, U12-type spliceosomal complex, cytoplasm, cytoplasmic stress granule, cytosol, endoplasmic reticulum, extracellular exosome, extracellular region, histone pre-mRNA 3'end processing complex, nucleoplasm, nucleus, plasma membrane, ribonucleoprotein complex, synapse
Pathways: Brain-derived neurotrophic factor (BDNF) signaling pathway, Cytokine Signaling in Immune system, Gene expression (Transcription), Generic Transcription Pathway, IL2, Immune System, Interferon Signaling, Interferon gamma signaling, MECP2 and Associated Rett Syndrome, Metabolism of RNA, NOTCH3 Activation and Transmission of Signal to the Nucleus, Noncanonical activation of NOTCH3, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling events mediated by PTP1B, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, transcriptional activation of dbpb from mrna
UniProt: P67809
Entrez ID: 4904
|
Does Knockout of KRTAP3-1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
KRTAP3-1
|
cell proliferation
|
Cancer Cell Line
|
Gene: KRTAP3-1 (keratin associated protein 3-1)
Type: protein-coding
Summary: This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: protein binding, structural molecule activity; CC: cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Keratinization
UniProt: Q9BYR8
Entrez ID: 83896
|
Does Knockout of TEKT3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
TEKT3
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: TEKT3 (tektin 3)
Type: protein-coding
Summary: This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. The exact function of this gene is not known. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cilium assembly, cilium movement involved in cell motility, flagellated sperm motility, regulation of brood size; CC: acrosomal membrane, acrosomal vesicle, axonemal A tubule inner sheath, axonemal microtubule, cell projection, cilium, cytoplasm, cytoplasmic vesicle, cytoskeleton, extracellular exosome, membrane, microtubule cytoskeleton, motile cilium, nucleus, outer acrosomal membrane, sperm flagellum
Pathways:
UniProt: Q9BXF9
Entrez ID: 64518
|
Does Knockout of PAN2 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
PAN2
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PAN2 (poly(A) specific ribonuclease subunit PAN2)
Type: protein-coding
Summary: This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: mRNA processing, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, nuclear-transcribed mRNA poly(A) tail shortening, positive regulation of cytoplasmic mRNA processing body assembly; MF: 3'-5'-RNA exonuclease activity, cysteine-type deubiquitinase activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, poly(A)-specific ribonuclease activity, protein binding; CC: P-body, PAN complex, cytoplasm, cytosol, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Ectoderm Differentiation, Metabolism of RNA, RNA degradation - Homo sapiens (human)
UniProt: Q504Q3
Entrez ID: 9924
|
Does Knockout of CHRNA3 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
CHRNA3
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit)
Type: protein-coding
Summary: This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009].
Gene Ontology: BP: acetylcholine receptor signaling pathway, behavioral response to nicotine, excitatory postsynaptic potential, locomotory behavior, membrane depolarization, monoatomic ion transmembrane transport, monoatomic ion transport, nervous system development, neuromuscular synaptic transmission, presynaptic modulation of chemical synaptic transmission, regulation of acetylcholine secretion, neurotransmission, regulation of dendrite morphogenesis, regulation of membrane potential, regulation of smooth muscle contraction, response to acetylcholine, response to nicotine, signal transduction, synaptic transmission involved in micturition, synaptic transmission, cholinergic; MF: acetylcholine binding, acetylcholine receptor activity, acetylcholine-gated monoatomic cation-selective channel activity, extracellular ligand-gated monoatomic ion channel activity, ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, protein binding, transmembrane signaling receptor activity; CC: Golgi apparatus, acetylcholine-gated channel complex, cation channel complex, ciliary basal body, cytosol, dendrite, endoplasmic reticulum, membrane, neuron projection, neuronal cell body, neurotransmitter receptor complex, nuclear speck, nucleolus, plasma membrane, plasma membrane raft, postsynaptic membrane, presynapse, synapse, synaptic membrane
Pathways: Acetylcholine binding and downstream events, Cholinergic synapse - Homo sapiens (human), Highly calcium permeable nicotinic acetylcholine receptors, Highly calcium permeable postsynaptic nicotinic acetylcholine receptors, Highly sodium permeable postsynaptic acetylcholine nicotinic receptors, Neuroactive ligand-receptor interaction - Homo sapiens (human), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nicotine Action Pathway, Nicotine Activity on Chromaffin Cells, Nicotine Activity on Dopaminergic Neurons, Nicotine Metabolism Pathway, Postsynaptic nicotinic acetylcholine receptors, Presynaptic nicotinic acetylcholine receptors, Transmission across Chemical Synapses
UniProt: P32297
Entrez ID: 1136
|
Does Knockout of SSB in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
SSB
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: SSB (small RNA binding exonuclease protection factor La)
Type: protein-coding
Summary: The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014].
Gene Ontology: BP: IRES-dependent viral translational initiation, RNA processing, histone mRNA metabolic process, nuclear histone mRNA catabolic process, positive regulation of translation, protein localization to cytoplasmic stress granule, tRNA 3'-end processing, tRNA 5'-leader removal, tRNA export from nucleus, tRNA modification, tRNA processing; MF: RNA binding, mRNA binding, nucleic acid binding, poly(U) RNA binding, protein binding, sequence-specific mRNA binding, tRNA binding; CC: chromosome, telomeric region, cytoplasm, cytoplasmic stress granule, cytosol, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Termination, Systemic lupus erythematosus - Homo sapiens (human)
UniProt: P05455
Entrez ID: 6741
|
Does Knockout of MCM2 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
MCM2
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: MCM2 (minichromosome maintenance complex component 2)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: DNA replication, DNA replication initiation, apoptotic process, cellular response to interleukin-4, cochlea development, double-strand break repair via break-induced replication, mitotic DNA replication initiation, nucleosome assembly, regulation of DNA-templated DNA replication initiation; MF: 3'-5' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, DNA replication origin binding, enzyme binding, helicase activity, histone binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity, zinc ion binding; CC: CMG complex, MCM complex, chromatin, chromosome, chromosome, telomeric region, cilium, cytoplasm, cytosol, nuclear chromosome, nuclear origin of replication recognition complex, nucleolus, nucleoplasm, nucleus
Pathways: ATR signaling pathway, Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Ciliary landscape, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA strand elongation, Developmental Biology, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, Unwinding of DNA, cdk regulation of dna replication
UniProt: P49736
Entrez ID: 4171
|
Does Knockout of EXOSC8 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
EXOSC8
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: EXOSC8 (exosome component 8)
Type: protein-coding
Summary: This gene encodes a 3'-5' exoribonuclease that specifically interacts with mRNAs containing AU-rich elements. The encoded protein is part of the exosome complex that is important for the degradation of numerous RNA species. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, U1 snRNA 3'-end processing, U4 snRNA 3'-end processing, U5 snRNA 3'-end processing, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nuclear mRNA surveillance, nuclear polyadenylation-dependent rRNA catabolic process, rRNA catabolic process, rRNA processing; MF: RNA binding, RNA exonuclease activity, identical protein binding, mRNA 3'-UTR AU-rich region binding, protein binding; CC: chromosome, cytoplasm, cytoplasmic exosome (RNase complex), cytosol, exoribonuclease complex, exosome (RNase complex), fibrillar center, nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA, Cellular responses to stimuli, Cellular responses to stress, Deadenylation-dependent mRNA decay, KSRP (KHSRP) binds and destabilizes mRNA, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, PERK regulates gene expression, RNA degradation - Homo sapiens (human), Regulation of mRNA stability by proteins that bind AU-rich elements, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA, Unfolded Protein Response (UPR), mRNA decay by 3' to 5' exoribonuclease, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q96B26
Entrez ID: 11340
|
Does Knockout of PGLYRP4 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
PGLYRP4
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: PGLYRP4 (peptidoglycan recognition protein 4)
Type: protein-coding
Summary: Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, defense response to Gram-positive bacterium, defense response to bacterium, detection of bacterium, immune response, immune system process, innate immune response, killing of cells of another organism, peptidoglycan catabolic process; MF: N-acetylmuramoyl-L-alanine amidase activity, peptidoglycan binding, peptidoglycan immune receptor activity, protein heterodimerization activity, zinc ion binding; CC: extracellular region, membrane, protein-containing complex
Pathways: Antimicrobial peptides, Immune System, Innate Immune System
UniProt: Q96LB8
Entrez ID: 57115
|
Does Knockout of TSR1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
TSR1
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: TSR1 (TSR1 ribosome maturation factor)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. Predicted to be part of preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), ribosome biogenesis; MF: GTP binding, GTPase activity, RNA binding, U3 snoRNA binding, protein binding; CC: cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q2NL82
Entrez ID: 55720
|
Does Knockout of SCAP in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
SCAP
|
cell proliferation
|
Cancer Cell Line
|
Gene: SCAP (SREBF chaperone)
Type: protein-coding
Summary: This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: COPII-coated vesicle cargo loading, SREBP signaling pathway, cholesterol metabolic process, immune response, lipid metabolic process, negative regulation of cholesterol biosynthetic process, positive regulation of cholesterol biosynthetic process, regulation of cholesterol biosynthetic process, regulation of fatty acid biosynthetic process, regulation of fatty acid metabolic process, response to hypoxia, response to insulin, response to vitamin B3, steroid metabolic process; MF: lipid binding, protein binding, protein-containing complex binding, sterol binding, unfolded protein binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, SREBP-SCAP complex, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, protein-containing complex
Pathways: Metabolism, Metabolism of lipids, Metabolism of steroids, RAGE, Regulation of cholesterol biosynthesis by SREBP (SREBF), Sterol regulatory element-binding proteins (SREBP) signaling, srebp control of lipid synthesis
UniProt: Q12770
Entrez ID: 22937
|
Does Knockout of C2orf81 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
C2orf81
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: C2orf81 (chromosome 2 open reading frame 81)
Type: protein-coding
Summary: Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: A6NN90
Entrez ID: 388963
|
Does Knockout of STAB1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
STAB1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: STAB1 (stabilin 1)
Type: protein-coding
Summary: This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, cell-cell signaling, defense response to bacterium, endocytosis, inflammatory response, negative regulation of angiogenesis, receptor-mediated endocytosis; MF: calcium ion binding, hyaluronic acid binding, low-density lipoprotein particle binding, low-density lipoprotein particle receptor activity, protein binding, protein-disulfide reductase activity, scavenger receptor activity; CC: endocytic vesicle membrane, membrane, plasma membrane
Pathways: Binding and Uptake of Ligands by Scavenger Receptors, Scavenging by Class H Receptors, Vesicle-mediated transport
UniProt: Q9NY15
Entrez ID: 23166
|
Does Knockout of CXXC4 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
CXXC4
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CXXC4 (CXXC finger protein 4)
Type: protein-coding
Summary: This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: Wnt signaling pathway, negative regulation of Wnt signaling pathway, zygotic specification of dorsal/ventral axis; MF: DNA binding, PDZ domain binding, metal ion binding, methyl-CpG binding, zinc ion binding; CC: cytoplasm, cytoplasmic vesicle, nucleus
Pathways: LncRNA involvement in canonical Wnt signaling and colorectal cancer, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), ncRNAs involved in Wnt signaling in hepatocellular carcinoma
UniProt: A0A8V8TLX0, J9JIF5
Entrez ID: 80319
|
Does Knockout of DR1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
DR1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: DR1 (down-regulator of transcription 1)
Type: protein-coding
Summary: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, general transcription initiation factor activity, protein binding, protein heterodimerization activity; CC: ATAC complex, RNA polymerase II transcription regulator complex, mitotic spindle, negative cofactor 2 complex, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones
UniProt: Q01658
Entrez ID: 1810
|
Does Knockout of NPIPB7 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
NPIPB7
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: NPIPB7 (nuclear pore complex interacting protein family member B7)
Type: protein-coding
Summary: Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: O75200
Entrez ID: 440350
|
Does Knockout of MIDN in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
MIDN
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: MIDN (midnolin)
Type: protein-coding
Summary: Predicted to enable kinase binding activity. Predicted to be involved in negative regulation of glucokinase activity and negative regulation of insulin secretion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of glucokinase activity, negative regulation of insulin secretion, proteasomal ubiquitin-independent protein catabolic process; MF: kinase binding, molecular adaptor activity, protein binding; CC: cytoplasm, cytosol, nucleolus, nucleus
Pathways:
UniProt: Q504T8
Entrez ID: 90007
|
Does Knockout of SCLT1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
SCLT1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: SCLT1 (sodium channel and clathrin linker 1)
Type: protein-coding
Summary: This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also been identified as a component of distal appendages of centrioles that is necessary for ciliogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: cilium assembly, clustering of voltage-gated sodium channels; MF: clathrin binding, protein binding, sodium channel regulator activity; CC: centriole, centrosome, ciliary basal body, ciliary transition fiber, clathrin complex, cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton
Pathways: Ciliopathies, Genes related to primary cilium development (based on CRISPR)
UniProt: Q96NL6
Entrez ID: 132320
|
Does Activation of HHEX in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
HHEX
|
response to virus
|
Hepatoma Cell Line
|
Gene: HHEX (hematopoietically expressed homeobox)
Type: protein-coding
Summary: This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell differentiation, DNA conformation change, Wnt signaling pathway, anterior/posterior pattern specification, cell differentiation, negative regulation of DNA-templated transcription, negative regulation of angiogenesis, negative regulation of cytoplasmic translational initiation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription by competitive promoter binding, negative regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of DNA-templated transcription, positive regulation of Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of transcription by RNA polymerase II, protein localization to nucleus, regulation of DNA-templated transcription, regulation of leukocyte proliferation, regulation of mRNA export from nucleus, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA binding, bending, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, TBP-class protein binding, eukaryotic initiation factor 4E binding, protein binding, protein homodimerization activity, sequence-specific DNA binding, transcription cis-regulatory region binding, translation regulator activity; CC: chromatin, cytoplasm, nuclear body, nucleus, protein-DNA complex
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Multipotent Pancreatic Progenitor Cells, Endoderm differentiation, Maturity onset diabetes of the young - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: Q03014
Entrez ID: 3087
|
Does Knockout of MRPL27 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
MRPL27
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: MRPL27 (mitochondrial ribosomal protein L27)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9P0M9
Entrez ID: 51264
|
Does Knockout of PDGFC in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
PDGFC
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PDGFC (platelet derived growth factor C)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: animal organ morphogenesis, bone development, cellular response to amino acid stimulus, central nervous system development, digestive tract development, fibroblast proliferation, platelet-derived growth factor receptor signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of cell division, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, positive regulation of fibroblast proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: growth factor activity, platelet-derived growth factor receptor binding, protein binding, protein homodimerization activity; CC: Golgi membrane, cell surface, cytoplasm, cytosol, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, membrane, nucleus, plasma membrane
Pathways: Calcium signaling pathway - Homo sapiens (human), Choline metabolism in cancer - Homo sapiens (human), EGFR Tyrosine Kinase Inhibitor Resistance, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Gap junction - Homo sapiens (human), MAPK signaling pathway - Homo sapiens (human), Melanoma - Homo sapiens (human), PDGF receptor signaling network, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Regulation of actin cytoskeleton - Homo sapiens (human), Signal Transduction, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases
UniProt: Q9NRA1
Entrez ID: 56034
|
Does Knockout of RPS27A in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
RPS27A
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: RPS27A (ribosomal protein S27a)
Type: protein-coding
Summary: Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008].
Gene Ontology: BP: cytoplasmic translation, modification-dependent protein catabolic process, protein ubiquitination, ribosomal small subunit biogenesis, translation; MF: RNA binding, metal ion binding, protein binding, protein tag activity, structural constituent of ribosome, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endocytic vesicle membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome membrane, extracellular exosome, extracellular space, membrane, mitochondrial outer membrane, nucleolus, nucleoplasm, nucleus, plasma membrane, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse, vesicle
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activated NOTCH1 Transmits Signal to the Nucleus, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Activation of NF-kappaB in B cells, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Adaptive Immune System, Adherens junctions interactions, Aerobic respiration and respiratory electron transport, Aggrephagy, Alpha-protein kinase 1 signaling pathway, Amyloid fiber formation, Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Antiviral mechanism by IFN-stimulated genes, Apoptosis, Asparagine N-linked glycosylation, Assembly Of The HIV Virion, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Autophagy, Axon guidance, Bacterial Infection Pathways, Beta-catenin independent WNT signaling, Budding and maturation of HIV virion, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Calnexin/calreticulin cycle, Cap-dependent Translation Initiation, Cargo recognition for clathrin-mediated endocytosis, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell death signalling via NRAGE, NRIF and NADE, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular response to chemical stress, Cellular response to hypoxia, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Chaperone Mediated Autophagy, Circadian clock, Class I MHC mediated antigen processing & presentation, Clathrin-mediated endocytosis, Co-inhibition by PD-1, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Coronavirus disease - COVID-19 - Homo sapiens (human), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, Cytoplasmic Ribosomal Proteins, Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, Deactivation of the beta-catenin transactivating complex, Death Receptor Signaling, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of carbohydrate metabolism, Diseases of metabolism, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downregulation of ERBB2 signaling, Downregulation of ERBB2:ERBB3 signaling, Downregulation of ERBB4 signaling, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Downregulation of TGF-beta receptor signaling, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, EGFR downregulation, ER Quality Control Compartment (ERQC), ER-Phagosome pathway, Endosomal Sorting Complex Required For Transport (ESCRT), Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Evasion by RSV of host interferon responses, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, FLT3 Signaling, FLT3 signaling by CBL mutants, FLT3 signaling in disease, Fanconi Anemia Pathway, Fc epsilon receptor (FCERI) signaling, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, G1 Phase, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), GTP hydrolysis and joining of the 60S ribosomal subunit, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Glycogen metabolism, Glycogen storage diseases, Glycogen synthesis, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HIV Infection, HIV Life Cycle, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Homology Directed Repair, Host Interactions of HIV factors, IKK complex recruitment mediated by RIP1, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, IRAK2 mediated activation of TAK1 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, ISG15 antiviral mechanism, Immune System, Inactivation of CSF3 (G-CSF) signaling, Infection with Mycobacterium tuberculosis, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, InlA-mediated entry of Listeria monocytogenes into host cells, InlB-mediated entry of Listeria monocytogenes into host cell, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, Ion channel transport, Iron uptake and transport, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Josephin domain DUBs, KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), L13a-mediated translational silencing of Ceruloplasmin expression, Late Phase of HIV Life Cycle, Late SARS-CoV-2 Infection Events, Late endosomal microautophagy, Listeria monocytogenes entry into host cells, M Phase, MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Macroautophagy, Major pathway of rRNA processing in the nucleolus and cytosol, Maturation of protein E, Membrane Trafficking, Membrane binding and targetting of GAG proteins, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, Metalloprotease DUBs, Mitophagy, Mitophagy - animal - Homo sapiens (human), Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Modulation by Mtb of host immune system, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Myoclonic epilepsy of Lafora, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, NF-kB is activated and signals survival, NIK-->noncanonical NF-kB signaling, NOD1/2 Signaling Pathway, NOTCH1 Intracellular Domain Regulates Transcription, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Neddylation, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of FLT3, Negative regulation of MAPK pathway, Negative regulation of MET activity, Negative regulation of NOTCH4 signaling, Negative regulators of DDX58/IFIH1 signaling, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear events mediated by NFE2L2, Nucleotide Excision Repair, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oncogene Induced Senescence, Orc1 removal from chromatin, Ovarian tumor domain proteases, Oxidative Stress Induced Senescence, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PD-L1(CD274) glycosylation and translocation to plasma membrane, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, PINK1-PRKN Mediated Mitophagy, PIP3 activates AKT signaling, PTEN Regulation, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Peptide chain elongation, Peroxisomal protein import, Pexophagy, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Post-translational protein modification, Prevention of phagosomal-lysosomal fusion, Processing of DNA double-strand break ends, Programmed Cell Death, Protein localization, Protein ubiquitination, Pyruvate metabolism, RAF/MAP kinase cascade, RAS processing, RIPK1-mediated regulated necrosis, RNA Polymerase II Transcription, RSV-host interactions, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Recognition of DNA damage by PCNA-containing replication complex, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulated Necrosis, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of BACH1 activity, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of FZD by ubiquitination, Regulation of Homotypic Cell-Cell Adhesion, Regulation of NF-kappa B signaling, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PLK1 Activity at G2/M Transition, Regulation of PTEN localization, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation, Regulation of TNFR1 signaling, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of innate immune responses to cytosolic DNA, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of necroptotic cell death, Regulation of pyruvate metabolism, Regulation of signaling by CBL, Respiratory Syncytial Virus Infection Pathway, Response of EIF2AK4 (GCN2) to amino acid deficiency, Response of Mtb to phagocytosis, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 activates/modulates innate immune responses, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, SPOP-mediated proteasomal degradation of PD-L1(CD274), SRP-dependent cotranslational protein targeting to membrane, Selective autophagy, Selenoamino acid metabolism, Selenocysteine synthesis, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by CSF1 (M-CSF) in myeloid cells, Signaling by CSF3 (G-CSF), Signaling by EGFR, Signaling by EGFR in Cancer, Signaling by ERBB2, Signaling by ERBB4, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Hedgehog, Signaling by Interleukins, Signaling by Ligand-Responsive EGFR Variants in Cancer, Signaling by MET, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD Domain Mutants in Cancer, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by NOTCH4, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spry regulation of FGF signaling, Stabilization of p53, Stimuli-sensing channels, Suppression of phagosomal maturation, Switching of origins to a post-replicative state, Synthesis And Processing Of GAG, GAGPOL Polyproteins, Synthesis of DNA, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, TAK1-dependent IKK and NF-kappa-B activation , TCF dependent signaling in response to WNT, TCR signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), TICAM1, RIP1-mediated IKK complex recruitment, TICAM1,TRAF6-dependent induction of TAK1 complex, TICAM1-dependent activation of IRF3/IRF7, TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR2 non-canonical NF-kB pathway, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , Termination of translesion DNA synthesis, The role of GTSE1 in G2/M progression after G2 checkpoint, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Translation initiation complex formation, Translation of Structural Proteins, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Homo sapiens (human), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, VLDLR internalisation and degradation, Vesicle-mediated transport, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Viral mRNA Translation, Vpu mediated degradation of CD4, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, activated TAK1 mediates p38 MAPK activation, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, p75 NTR receptor-mediated signalling, p75NTR recruits signalling complexes, p75NTR signals via NF-kB, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62979
Entrez ID: 6233
|
Does Knockout of DENND1B in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
DENND1B
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: DENND1B (DENN domain containing 1B)
Type: protein-coding
Summary: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: T cell receptor signaling pathway, endocytic recycling, endocytosis, positive regulation of T-helper 2 cell cytokine production, protein transport, regulation of immune response; MF: guanyl-nucleotide exchange factor activity, phosphatidylinositol phosphate binding, protein binding, small GTPase binding; CC: clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, intracellular membrane-bounded organelle, nuclear speck
Pathways: Membrane Trafficking, RAB GEFs exchange GTP for GDP on RABs, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: Q6P3S1
Entrez ID: 163486
|
Does Knockout of SHOC2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
SHOC2
|
cell proliferation
|
Cancer Cell Line
|
Gene: SHOC2 (SHOC2 leucine rich repeat scaffold protein)
Type: protein-coding
Summary: This gene encodes a protein that consists almost entirely of leucine-rich repeats, a domain implicated in protein-protein interactions. The protein may function as a scaffold linking RAS to downstream signal transducers in the RAS/ERK MAP kinase signaling cascade. Mutations in this gene have been associated with Noonan-like syndrome with loose anagen hair. [provided by RefSeq, May 2010].
Gene Ontology: BP: cellular response to growth hormone stimulus, cyclic-GMP-AMP transmembrane import across plasma membrane, fibroblast growth factor receptor signaling pathway, intracellular signal transduction, negative regulation of neural precursor cell proliferation, negative regulation of neuron differentiation, nerve growth factor signaling pathway, positive regulation of Ras protein signal transduction, positive regulation of neuron differentiation, positive regulation of neuron projection development, regulation of MAPK cascade; MF: protein binding, protein phosphatase 1 binding, protein phosphatase binding, protein phosphatase regulator activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, protein phosphatase type 1 complex
Pathways: 22q11.2 copy number variation syndrome, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Gain-of-function MRAS complexes activate RAF signaling, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Oncogenic MAPK signaling, RAF activation, RAF/MAP kinase cascade, Ras signaling, Ras signaling pathway - Homo sapiens (human), SHOC2 M1731 mutant abolishes MRAS complex function, Signal Transduction, Signaling by MRAS-complex mutants
UniProt: Q9UQ13
Entrez ID: 8036
|
Does Knockout of OR8G2P in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
OR8G2P
|
response to virus
|
Lung Cancer Cell Line
|
Gene: OR8G2P (olfactory receptor family 8 subfamily G member 2 pseudogene)
Type: pseudo
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: GPCRs, Other
UniProt:
Entrez ID: 26492
|
Does Activation of HNRNPCL4 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
HNRNPCL4
|
protein/peptide accumulation
|
T cell
|
Gene: HNRNPCL4 (heterogeneous nuclear ribonucleoprotein C like 4)
Type: protein-coding
Summary: Predicted to enable RNA binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, nucleic acid binding; CC: nucleus
Pathways:
UniProt: P0DMR1, B7ZW38
Entrez ID: 101060301
|
Does Knockout of OR5D18 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
OR5D18
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: OR5D18 (olfactory receptor family 5 subfamily D member 18)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGL1
Entrez ID: 219438
|
Does Knockout of POP4 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
POP4
|
cell proliferation
|
Cancer Cell Line
|
Gene: POP4 (POP4 ribonuclease P/MRP subunit)
Type: protein-coding
Summary: This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: RNA processing, rRNA processing, tRNA 5'-leader removal, tRNA processing; MF: RNA binding, protein binding, ribonuclease P RNA binding, ribonuclease P activity; CC: multimeric ribonuclease P complex, nucleolus, nucleoplasm, nucleus, ribonuclease MRP complex, ribonuclease P complex
Pathways: Metabolism of RNA, RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), tRNA processing, tRNA processing in the nucleus
UniProt: O95707
Entrez ID: 10775
|
Does Knockout of MTHFR in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
MTHFR
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MTHFR (methylenetetrahydrofolate reductase)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: S-adenosylmethionine metabolic process, heterochromatin organization, homocysteine metabolic process, methionine biosynthetic process, methionine metabolic process, neural tube closure, response to amino acid, response to folic acid, response to hypoxia, response to interleukin-1, response to vitamin B2, response to xenobiotic stimulus, tetrahydrofolate interconversion, tetrahydrofolate metabolic process; MF: FAD binding, NADP binding, catalytic activity, flavin adenine dinucleotide binding, methylenetetrahydrofolate reductase (NADPH) activity, methylenetetrahydrofolate reductase [NAD(P)H] activity, modified amino acid binding, oxidoreductase activity, protein binding, protein-containing complex binding; CC: cytosol
Pathways: Cystathionine Beta-Synthase Deficiency, Ethanol effects on histone modifications, Fluoropyrimidine Activity, Folate Metabolism, Folate malabsorption, hereditary, Folate-Alcohol and Cancer Pathway Hypotheses, Glycine Metabolism, Glycine N-methyltransferase Deficiency, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, MTHFR deficiency, Male infertility, Metabolism, Metabolism of folate and pterines, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Methionine Adenosyltransferase Deficiency, Methionine Metabolism, Methotrexate Action Pathway, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), One carbon pool by folate - Homo sapiens (human), One-carbon metabolism, One-carbon metabolism and related pathways, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, Selenium Micronutrient Network, Trans-sulfuration and one-carbon metabolism, Vitamin B12 metabolism, folate transformations
UniProt: P42898
Entrez ID: 4524
|
Does Knockout of EYA1 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,631
|
Knockout
|
EYA1
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: EYA1 (EYA transcriptional coactivator and phosphatase 1)
Type: protein-coding
Summary: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may play a role in the developing kidney, branchial arches, eye, and ear. Mutations of this gene have been associated with branchiootorenal dysplasia syndrome, branchiootic syndrome, and sporadic cases of congenital cataracts and ocular anterior segment anomalies. A similar protein in mice can act as a transcriptional activator. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: DNA damage response, DNA repair, anatomical structure morphogenesis, animal organ morphogenesis, aorta morphogenesis, branching involved in ureteric bud morphogenesis, cell differentiation, cell fate commitment, chromatin organization, chromatin remodeling, cochlea morphogenesis, double-strand break repair, embryonic skeletal system morphogenesis, epithelial cell proliferation, extrinsic apoptotic signaling pathway in absence of ligand, inner ear morphogenesis, mesodermal cell fate specification, metanephros development, middle ear morphogenesis, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, neuron fate specification, otic vesicle development, otic vesicle morphogenesis, outer ear morphogenesis, outflow tract morphogenesis, pattern specification process, pharyngeal system development, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of epithelial cell proliferation, positive regulation of secondary heart field cardioblast proliferation, positive regulation of transcription by RNA polymerase II, protein sumoylation, regulation of neuron differentiation, response to ionizing radiation, semicircular canal morphogenesis, sensory perception of sound, striated muscle tissue development, ureteric bud development; MF: RNA binding, histone H2AXY142 phosphatase activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity; CC: cytoplasm, nuclear body, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex
Pathways: DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Developmental Biology, Formation of the ureteric bud, GDNF-RET signaling axis, Genes controlling nephrogenesis, Kidney development, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: Q99502
Entrez ID: 2138
|
Does Knockout of BCL9 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
BCL9
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: BCL9 (BCL9 transcription coactivator)
Type: protein-coding
Summary: BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Wnt signaling pathway, canonical Wnt signaling pathway, myoblast differentiation, myotube differentiation involved in skeletal muscle regeneration, positive regulation of transcription by RNA polymerase II, regulation of transforming growth factor beta receptor signaling pathway, skeletal muscle cell differentiation, somatic stem cell population maintenance, transcription by RNA polymerase II; MF: beta-catenin binding, protein binding, transcription coactivator activity; CC: Golgi apparatus, beta-catenin-TCF complex, cis-Golgi network, cytoplasm, nucleoplasm, nucleus, sarcoplasm
Pathways: 1q21.1 copy number variation syndrome, Deactivation of the beta-catenin transactivating complex, Formation of the beta-catenin:TCF transactivating complex, Regulation of nuclear beta catenin signaling and target gene transcription, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt, Wnt Signaling Pathway, Wnt-beta-catenin signaling pathway in leukemia
UniProt: O00512
Entrez ID: 607
|
Does Knockout of ADAMTS20 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
ADAMTS20
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif 20)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the ADAMTS family of zinc-dependent proteases. The encoded protein has a signal peptide that is cleaved to release the mature peptide, which is secreted and found in the extracellular matrix. This protein may be involved in tissue remodeling. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: apoptotic process, extracellular matrix organization, melanocyte differentiation, negative regulation of apoptotic process, positive regulation of melanocyte differentiation, positive regulation of signal transduction, proteolysis, regulation of developmental pigmentation, signal transduction; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Defective B3GALTL causes PpS, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: P59510
Entrez ID: 80070
|
Does Knockout of ACTR6 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
ACTR6
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: ACTR6 (actin related protein 6)
Type: protein-coding
Summary: Predicted to enable nucleosome binding activity. Predicted to be involved in histone exchange. Predicted to be located in nucleus. Predicted to be part of Swr1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin remodeling, negative regulation of transcription by RNA polymerase I, nucleolus organization, positive regulation of transcription by RNA polymerase I, regulation of DNA-templated transcription; MF: nucleosome binding, protein binding; CC: Swr1 complex, cytoplasm, cytoskeleton, nucleolus, nucleosome, nucleus
Pathways:
UniProt: Q9GZN1
Entrez ID: 64431
|
Does Knockout of TP53RK in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
TP53RK
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: TP53RK (TP53 regulating kinase)
Type: protein-coding
Summary: Enables p53 binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 4. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein phosphorylation, regulation of signal transduction by p53 class mediator, tRNA processing, tRNA threonylcarbamoyladenosine metabolic process; MF: ATP binding, catalytic activity, hydrolase activity, kinase activity, nucleotide binding, p53 binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: EKC/KEOPS complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53, tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q96S44
Entrez ID: 112858
|
Does Knockout of DRAP1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
DRAP1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: DRAP1 (DR1 associated protein 1)
Type: protein-coding
Summary: Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II general transcription initiation factor binding, TBP-class protein binding, core promoter sequence-specific DNA binding, identical protein binding, protein binding, protein heterodimerization activity; CC: RNA polymerase II transcription regulator complex, negative cofactor 2 complex, nucleus
Pathways: Developmental Biology, Signal Transduction, Signaling by Activin, Signaling by NODAL, Signaling by TGFB family members
UniProt: Q14919
Entrez ID: 10589
|
Does Knockout of SCN10A in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
SCN10A
|
response to virus
|
Lung Cancer Cell Line
|
Gene: SCN10A (sodium voltage-gated channel alpha subunit 10)
Type: protein-coding
Summary: The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
Gene Ontology: BP: AV node cell action potential, bundle of His cell action potential, cardiac muscle cell action potential involved in contraction, membrane depolarization during action potential, monoatomic ion transmembrane transport, monoatomic ion transport, odontogenesis of dentin-containing tooth, regulation of atrial cardiac muscle cell membrane depolarization, regulation of cardiac muscle contraction, regulation of heart rate, regulation of monoatomic ion transmembrane transport, regulation of presynaptic membrane potential, sensory perception, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: monoatomic cation channel activity, monoatomic ion channel activity, sodium channel activity, transmembrane transporter binding, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, voltage-gated sodium channel activity; CC: axon, clathrin complex, extracellular exosome, glutamatergic synapse, membrane, monoatomic ion channel complex, plasma membrane, presynaptic membrane, voltage-gated sodium channel complex
Pathways: 3-Methylthiofentanyl Action Pathway, Alfentanil Action Pathway, Alvimopan Action Pathway, Anileridine Action Pathway, Axon guidance, Benzocaine Action Pathway, Bupivacaine Action Pathway, Buprenorphine Action Pathway, Cardiac conduction, Carfentanil Action Pathway, Chloroprocaine Action Pathway, Citalopram Action Pathway, Cocaine Action Pathway, Codeine Action Pathway, Desipramine Action Pathway, Developmental Biology, Dezocine Action Pathway, Dibucaine Action Pathway, Dihydromorphine Action Pathway, Dimethylthiambutene Action Pathway, Diphenoxylate Action Pathway, Escitalopram Action Pathway, Ethylmorphine Action Pathway, Fentanyl Action Pathway, Fluoxetine Action Pathway, Heroin Action Pathway, Hydrocodone Action Pathway, Hydromorphone Action Pathway, Imipramine Action Pathway, Interaction between L1 and Ankyrins, Ketobemidone Action Pathway, L1CAM interactions, Levallorphan Action Pathway, Levobupivacaine Action Pathway, Levomethadyl Acetate Action Action Pathway, Levorphanol Action Pathway, Lidocaine (Local Anaesthetic) Action Pathway, Lidocaine (Local Anaesthetic) Metabolism Pathway, Mepivacaine Action Pathway, Methadone Action Pathway, Methadyl Acetate Action Pathway, Morphine Action Pathway, Muscle contraction, Nalbuphine Action Pathway, Naloxone Action Pathway, Naltrexone Action Pathway, Nervous system development, Nicotine Action Pathway, Oxybuprocaine Action Pathway, Oxycodone Action Pathway, Oxymorphone Action Pathway, Pentazocine Action Pathway, Phase 0 - rapid depolarisation, Prilocaine Action Pathway, Procaine Action Pathway, Proparacaine Action Pathway, Propoxyphene Action Pathway, Remifentanil Action Pathway, Ropivacaine Action Pathway, Sufentanil Action Pathway, Tramadol Action Action Pathway
UniProt: Q9Y5Y9
Entrez ID: 6336
|
Does Knockout of FCGR1A in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
FCGR1A
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: FCGR1A (Fc gamma receptor Ia)
Type: protein-coding
Summary: This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Fc-gamma receptor signaling pathway, antibody-dependent cellular cytotoxicity, antigen processing and presentation of exogenous antigen, antigen processing and presentation of exogenous peptide antigen via MHC class I, cell surface receptor signaling pathway, defense response to bacterium, immune response, immune system process, innate immune response, phagocytosis, engulfment, phagocytosis, recognition, positive regulation of phagocytosis, positive regulation of tumor necrosis factor production, positive regulation of type III hypersensitivity, positive regulation of type IIa hypersensitivity, receptor-mediated endocytosis, regulation of immune response, response to bacterium, signal transduction; MF: IgG binding, IgG receptor activity, high-affinity IgG receptor activity, protein binding; CC: clathrin-coated endocytic vesicle membrane, early endosome membrane, external side of plasma membrane, membrane, plasma membrane
Pathways: Acute myeloid leukemia - Homo sapiens (human), Adaptive Immune System, Anti-inflammatory response favouring Leishmania parasite infection, Antigen processing-Cross presentation, Class I MHC mediated antigen processing & presentation, Cross-presentation of soluble exogenous antigens (endosomes), Cytokine Signaling in Immune system, Disease, FCGR activation, FCGR3A-mediated IL10 synthesis, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, Hematopoietic cell lineage - Homo sapiens (human), Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Infectious disease, Innate Immune System, Interferon Signaling, Interferon gamma signaling, Leishmania infection, Leishmania parasite growth and survival, Leishmaniasis - Homo sapiens (human), Microglia Pathogen Phagocytosis Pathway, Neutrophil extracellular trap formation - Homo sapiens (human), Osteoclast differentiation - Homo sapiens (human), Parasitic Infection Pathways, Phagosome - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Role of phospholipids in phagocytosis, Staphylococcus aureus infection - Homo sapiens (human), Systemic lupus erythematosus - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), Tuberculosis - Homo sapiens (human)
UniProt: P12314
Entrez ID: 2209
|
Does Activation of KIN in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
KIN
|
protein/peptide accumulation
|
T cell
|
Gene: KIN (Kin17 DNA and RNA binding protein)
Type: protein-coding
Summary: The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, DNA replication, mRNA processing; MF: DNA binding, RNA binding, double-stranded DNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol, nuclear matrix, nucleoplasm, nucleus, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Protein methylation
UniProt: O60870
Entrez ID: 22944
|
Does Knockout of COA5 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
COA5
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: COA5 (cytochrome c oxidase assembly factor 5)
Type: protein-coding
Summary: This gene encodes an ortholog of yeast Pet191, which in yeast is a subunit of a large oligomeric complex associated with the mitochondrial inner membrane, and required for the assembly of the cytochrome c oxidase complex. Mutations in this gene are associated with mitochondrial complex IV deficiency, a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to a severe disease affecting several tissues and organs. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: leukocyte differentiation, mitochondrial cytochrome c oxidase assembly, multicellular organism growth, spleen development, thymus development; CC: mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: Q86WW8
Entrez ID: 493753
|
Does Knockout of EMILIN3 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
EMILIN3
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: EMILIN3 (elastin microfibril interfacer 3)
Type: protein-coding
Summary: Enables identical protein binding activity. Part of collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: extracellular matrix constituent conferring elasticity, identical protein binding, protein binding; CC: cytoplasm, extracellular matrix, extracellular region
Pathways: Elastic fibre formation, Extracellular matrix organization, Molecules associated with elastic fibres
UniProt: Q9NT22
Entrez ID: 90187
|
Does Knockout of ODAM in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
ODAM
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: ODAM (odontogenic, ameloblast associated)
Type: protein-coding
Summary: Involved in several processes, including positive regulation of GTPase activity; positive regulation of epithelial cell proliferation involved in wound healing; and positive regulation of macromolecule metabolic process. Located in several cellular components, including extracellular space; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: biomineral tissue development, inflammatory response, odontogenesis of dentin-containing tooth, positive regulation of GTPase activity, positive regulation of epithelial cell proliferation involved in wound healing, positive regulation of gene expression, positive regulation of protein phosphorylation, regulation of actin cytoskeleton organization, response to wounding; CC: cell periphery, cytoplasm, cytosol, extracellular region, extracellular space, mitotic spindle, nucleoplasm, nucleus, supramolecular fiber
Pathways: Amyloid fiber formation, Metabolism of proteins
UniProt: A1E959
Entrez ID: 54959
|
Does Knockout of LEMD2 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
LEMD2
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: LEMD2 (LEM domain nuclear envelope protein 2)
Type: protein-coding
Summary: This gene encodes a LEM domain-containing transmembrane protein of the inner nuclear membrane. The protein is involved in nuclear structure organization and plays a role in cell signaling and differentiation. Mutations in this gene result in Cataract 46, juvenile-onset. Multiple transcript variants have been found for this gene. [provided by RefSeq, Feb 2017].
Gene Ontology: BP: heart formation, negative regulation of MAPK cascade, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, neurogenesis, nuclear envelope organization, nuclear membrane organization, protein localization to chromatin, skeletal muscle cell differentiation; CC: chromatin, cytoplasm, cytoskeleton, endoplasmic reticulum, membrane, nuclear envelope, nuclear inner membrane, nuclear membrane, nuclear periphery, nucleus, spindle
Pathways: Cell Cycle, Cell Cycle, Mitotic, Depolymerization of the Nuclear Lamina, Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Sealing of the nuclear envelope (NE) by ESCRT-III
UniProt: Q8NC56
Entrez ID: 221496
|
Does Knockout of CENPI in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
CENPI
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CENPI (centromere protein I)
Type: protein-coding
Summary: This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: CENP-A containing chromatin assembly, centromere complex assembly, chromosome segregation, mitotic sister chromatid segregation, sex differentiation; CC: chromosome, chromosome, centromeric region, cytosol, inner kinetochore, kinetochore, nuclear body, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q92674
Entrez ID: 2491
|
Does Knockout of DDX56 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
DDX56
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: DDX56 (DEAD-box helicase 56)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: cytoplasmic pattern recognition receptor signaling pathway, defense response to virus, host-mediated perturbation of viral RNA genome replication, negative regulation of type I interferon production, positive regulation of neuron projection development, protein import into nucleus, rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA stem-loop binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding, protein sequestering activity; CC: cytosol, membrane, nucleolus, nucleus
Pathways:
UniProt: Q9NY93
Entrez ID: 54606
|
Does Knockout of IFT140 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
IFT140
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: IFT140 (intraflagellar transport 140)
Type: protein-coding
Summary: This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012].
Gene Ontology: BP: cell projection organization, cilium assembly, determination of left/right symmetry, embryonic brain development, embryonic camera-type eye development, embryonic cranial skeleton morphogenesis, embryonic digit morphogenesis, heart development, intraciliary retrograde transport, intraciliary transport, limb morphogenesis, neural tube patterning, non-motile cilium assembly, photoreceptor cell outer segment organization, protein localization to cilium, regulation of cilium assembly, regulation of smoothened signaling pathway; CC: axoneme, cell projection, centriole, centrosome, ciliary basal body, ciliary tip, cilium, cone photoreceptor outer segment, cytoplasm, cytoskeleton, intraciliary transport particle A, mitochondrion, non-motile cilium, nucleoplasm, photoreceptor connecting cilium
Pathways: Ciliary landscape, Ciliopathies, Cilium Assembly, Genes related to primary cilium development (based on CRISPR), Hedgehog 'off' state, Intraflagellar transport, Intraflagellar transport proteins binding to dynein, Organelle biogenesis and maintenance, Signal Transduction, Signaling by Hedgehog
UniProt: Q96RY7
Entrez ID: 9742
|
Does Knockout of RAD9A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
RAD9A
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RAD9A (RAD9 checkpoint clamp component A)
Type: protein-coding
Summary: This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, DNA replication checkpoint signaling, cellular response to ionizing radiation, intrinsic apoptotic signaling pathway in response to DNA damage, mitotic intra-S DNA damage checkpoint signaling, positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; MF: 3'-5' exonuclease activity, SH3 domain binding, double-stranded DNA 3'-5' DNA exonuclease activity, enzyme binding, exonuclease activity, histone deacetylase binding, hydrolase activity, nuclease activity, protein binding, protein kinase binding; CC: checkpoint clamp complex, cytoplasm, nucleoplasm, nucleus
Pathways: ATM Signaling Pathway, ATM pathway, ATR Signaling, ATR signaling pathway, Activation of ATR in response to replication stress, Androgen receptor signaling pathway, Cell Cycle, Cell Cycle Checkpoints, Cellular senescence - Homo sapiens (human), DNA Double-Strand Break Repair, DNA IR-double strand breaks and cellular response via ATM, DNA Repair, DNA damage response, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Fanconi anemia pathway, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Impaired BRCA2 binding to RAD51, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of Telomerase, Transcriptional Regulation by TP53, miRNA regulation of DNA damage response, role of brca1 brca2 and atr in cancer susceptibility
UniProt: Q99638
Entrez ID: 5883
|
Does Knockout of CR1L in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
CR1L
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CR1L (complement C3b/C4b receptor 1 like)
Type: protein-coding
Summary: Acts upstream of or within regulation of complement activation and regulation of complement-dependent cytotoxicity. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: T cell mediated immunity, negative regulation of complement activation, classical pathway, regulation of complement activation, regulation of complement-dependent cytotoxicity; CC: cytoplasm, extracellular region, extracellular space, membrane, plasma membrane, receptor complex
Pathways: Complement and coagulation cascades - Homo sapiens (human), Hematopoietic cell lineage - Homo sapiens (human), Legionellosis - Homo sapiens (human), Leishmaniasis - Homo sapiens (human), Malaria - Homo sapiens (human), Neutrophil extracellular trap formation - Homo sapiens (human), Tuberculosis - Homo sapiens (human)
UniProt: Q2VPA4
Entrez ID: 1379
|
Does Knockout of HNRNPH1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
HNRNPH1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1)
Type: protein-coding
Summary: This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012].
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, regulation of RNA splicing; MF: RNA binding, identical protein binding, nucleic acid binding, poly(U) RNA binding, protein binding; CC: catalytic step 2 spliceosome, cytosol, membrane, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways: FGFR2 alternative splicing, Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells, MECP2 and Associated Rett Syndrome, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Receptor Tyrosine Kinases, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P31943
Entrez ID: 3187
|
Does Knockout of AKAP10 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
AKAP10
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: AKAP10 (A-kinase anchoring protein 10)
Type: protein-coding
Summary: This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012].
Gene Ontology: BP: intracellular protein localization, signal transduction; MF: protein binding, protein kinase A binding; CC: cytoplasm, cytosol, membrane, mitochondrion, plasma membrane, protein-containing complex
Pathways: Factors involved in megakaryocyte development and platelet production, G Protein Signaling Pathways, Hemostasis
UniProt: O43572
Entrez ID: 11216
|
Does Knockout of GTF2F1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
GTF2F1
|
cell proliferation
|
Cancer Cell Line
|
Gene: GTF2F1 (general transcription factor IIF subunit 1)
Type: protein-coding
Summary: Enables several functions, including RNA polymerase II general transcription initiation factor activity; phosphatase activator activity; and promoter-specific chromatin binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; response to virus; and transcription initiation from RNA polymerase II promoter. Located in cell junction and nucleoplasm. Part of transcription factor TFIID complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of protein binding, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, response to virus, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase II general transcription initiation factor binding, TFIIF-class transcription factor complex binding, phosphatase activator activity, promoter-specific chromatin binding, protein binding, protein domain specific binding, protein phosphatase binding; CC: cell junction, nucleoplasm, nucleus, protein-containing complex, transcription factor TFIID complex, transcription factor TFIIF complex
Pathways: Abortive elongation of HIV-1 transcript in the absence of Tat, AndrogenReceptor, Basal transcription factors - Homo sapiens (human), Disease, Diseases of signal transduction by growth factor receptors and second messengers, ESR-mediated signaling, Estrogen-dependent gene expression, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, HIV elongation arrest and recovery, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Late Phase of HIV Life Cycle, Metabolism of RNA, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, Processing of Capped Intron-Containing Pre-mRNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcriptional Regulation by TP53, Viral Infection Pathways, Viral Messenger RNA Synthesis, carm1 and regulation of the estrogen receptor, chromatin remodeling by hswi/snf atp-dependent complexes, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, the information processing pathway at the ifn beta enhancer
UniProt: P35269
Entrez ID: 2962
|
Does Knockout of MORN5 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
MORN5
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: MORN5 (MORN repeat containing 5)
Type: protein-coding
Summary: Predicted to be located in sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cell projection, cilium, motile cilium, sperm flagellum
Pathways:
UniProt: Q5VZ52
Entrez ID: 254956
|
Does Knockout of EED in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
EED
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: EED (embryonic ectoderm development)
Type: protein-coding
Summary: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, chromatin organization, facultative heterochromatin formation, genomic imprinting, heterochromatin formation, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, oligodendrocyte differentiation, regulation of adaxial/abaxial pattern formation, spinal cord development; MF: chromatin binding, enzyme activator activity, identical protein binding, nucleosome binding, protein binding, transcription corepressor binding; CC: ESC/E(Z) complex, chromatin silencing complex, chromosome, cytosol, nucleoplasm, nucleus, pronucleus, sex chromatin
Pathways: Epithelial to mesenchymal transition in colorectal cancer, FBXL10 enhancement of MAP-ERK signaling in diffuse large B-cell lymphoma, Histone Modifications, Interactome of polycomb repressive complex 2 (PRC2), TNFalpha, Tumor suppressor activity of SMARCB1, the prc2 complex sets long-term gene silencing through modification of histone tails
UniProt: O75530
Entrez ID: 8726
|
Does Knockout of FBXO39 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
FBXO39
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: FBXO39 (F-box protein 39)
Type: protein-coding
Summary: Members of the F-box protein family, such as FBXO39, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].
Gene Ontology:
Pathways:
UniProt: Q8N4B4
Entrez ID: 162517
|
Does Knockout of FAM184B in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
FAM184B
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: FAM184B (family with sequence similarity 184 member B)
Type: protein-coding
Summary: family with sequence similarity 184 member B
Gene Ontology:
Pathways:
UniProt: Q9ULE4
Entrez ID: 27146
|
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