prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of BTBD7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
BTBD7
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: BTBD7 (BTB domain containing 7)
Type: protein-coding
Summary: Predicted to be involved in regulation of branching involved in salivary gland morphogenesis. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: morphogenesis of a branching epithelium, regulation of branching involved in salivary gland morphogenesis; CC: nucleus
Pathways:
UniProt: Q9P203
Entrez ID: 55727
|
Does Knockout of TP53BP2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
TP53BP2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TP53BP2 (tumor protein p53 binding protein 2)
Type: protein-coding
Summary: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of cell cycle, positive regulation of execution phase of apoptosis, regulation of apoptotic process, signal transduction; MF: NF-kappaB binding, SH3 domain binding, identical protein binding, p53 binding, protein binding, protein homodimerization activity; CC: cell junction, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Direct p53 effectors, Hippo signaling pathway - Homo sapiens (human)
UniProt: Q13625
Entrez ID: 7159
|
Does Knockout of BCL9L in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
BCL9L
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: BCL9L (BCL9 like)
Type: protein-coding
Summary: Enables beta-catenin binding activity. Involved in several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; and positive regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: canonical Wnt signaling pathway, myoblast differentiation, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of epithelial to mesenchymal transition, positive regulation of transcription by RNA polymerase II, regulation of cell morphogenesis, skeletal muscle cell differentiation, somatic stem cell population maintenance, transcription by RNA polymerase II; MF: beta-catenin binding, transcription coactivator activity; CC: beta-catenin-TCF complex, fibrillar center, nucleoplasm, nucleus
Pathways: Deactivation of the beta-catenin transactivating complex, Formation of the beta-catenin:TCF transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q86UU0
Entrez ID: 283149
|
Does Knockout of NUP43 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
NUP43
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NUP43 (nucleoporin 43)
Type: protein-coding
Summary: Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell division, chromosome segregation, mRNA transport, nucleocytoplasmic transport, protein transport; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, nuclear envelope, nuclear pore, nuclear pore outer ring, nuclear speck, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, EML4 and NUDC in mitotic spindle formation, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q8NFH3
Entrez ID: 348995
|
Does Knockout of PES1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
PES1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: PES1 (pescadillo ribosomal biogenesis factor 1)
Type: protein-coding
Summary: This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: cell population proliferation, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, regulation of cell cycle, ribosomal large subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding, ribonucleoprotein complex binding; CC: PeBoW complex, chromosome, cytosol, membrane, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O00541
Entrez ID: 23481
|
Does Knockout of MS4A15 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
MS4A15
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: MS4A15 (membrane spanning 4-domains A15)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q8N5U1
Entrez ID: 219995
|
Does Knockout of PTCD3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
PTCD3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PTCD3 (pentatricopeptide repeat domain 3)
Type: protein-coding
Summary: Enables rRNA binding activity and ribosomal small subunit binding activity. Involved in mitochondrial translation. Located in several cellular components, including cytosol; mitochondrion; and nucleoplasm. Implicated in combined oxidative phosphorylation deficiency 51. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mitochondrial translation, regulation of translation; MF: RNA binding, protein binding, rRNA binding, ribosomal small subunit binding; CC: cytosol, mitochondrial inner membrane, mitochondrial matrix, mitochondrial small ribosomal subunit, mitochondrion, nucleoplasm, plasma membrane, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q96EY7
Entrez ID: 55037
|
Does Knockout of CALML5 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
CALML5
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: CALML5 (calmodulin like 5)
Type: protein-coding
Summary: This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: epidermis development, microtubule cytoskeleton organization, signal transduction; MF: calcium ion binding, enzyme regulator activity, metal ion binding, protein binding; CC: cytoplasm, extracellular region, ficolin-1-rich granule lumen
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alcoholism - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Amphetamine addiction - Homo sapiens (human), Apelin signaling pathway - Homo sapiens (human), C-type lectin receptor signaling pathway - Homo sapiens (human), Calcium signaling pathway - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin, Dopaminergic synapse - Homo sapiens (human), Estrogen signaling pathway - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), Gastric acid secretion - Homo sapiens (human), Glioma - Homo sapiens (human), Glucagon signaling pathway - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Immune System, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Innate Immune System, Insulin signaling pathway - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), Melanogenesis - Homo sapiens (human), Melanoma, Neurotrophin signaling pathway - Homo sapiens (human), Neutrophil degranulation, Olfactory transduction - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Oxytocin signaling pathway - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Pertussis - Homo sapiens (human), Phosphatidylinositol signaling system - Homo sapiens (human), Phototransduction - Homo sapiens (human), Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Renin secretion - Homo sapiens (human), Renin-angiotensin-aldosterone system (RAAS), Salivary secretion - Homo sapiens (human), Tuberculosis - Homo sapiens (human), Vascular smooth muscle contraction - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: Q9NZT1
Entrez ID: 51806
|
Does Knockout of INIP in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
INIP
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: INIP (INTS3 and NABP interacting protein)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination repair. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via homologous recombination, mitotic G2/M transition checkpoint, response to ionizing radiation; CC: SOSS complex, nucleoplasm, nucleus, site of double-strand break
Pathways:
UniProt: Q9NRY2
Entrez ID: 58493
|
Does Knockout of UCN2 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
UCN2
|
response to chemicals
|
Melanoma Cell Line
|
Gene: UCN2 (urocortin 2)
Type: protein-coding
Summary: This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: adenylate cyclase-activating G protein-coupled receptor signaling pathway, cellular response to nutrient levels, digestion, hormone-mediated signaling pathway; MF: G protein-coupled receptor binding, corticotropin-releasing hormone receptor 2 binding, corticotropin-releasing hormone receptor binding, hormone activity, hormone binding, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Class B/2 (Secretin family receptors), GPCR ligand binding, Neuroactive ligand-receptor interaction - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q96RP3
Entrez ID: 90226
|
Does Knockout of PNISR in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
PNISR
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: PNISR (PNN interacting serine and arginine rich protein)
Type: protein-coding
Summary: Enables RNA binding activity. Located in cytosol; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, nuclear speck, nucleoplasm, nucleus, plasma membrane, presynaptic active zone
Pathways:
UniProt: Q8TF01
Entrez ID: 25957
|
Does Knockout of RPL37 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
RPL37
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RPL37 (ribosomal protein L37)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, positive regulation of signal transduction by p53 class mediator, translation; MF: MDM2/MDM4 family protein binding, RNA binding, metal ion binding, rRNA binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity, zinc ion binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P61927
Entrez ID: 6167
|
Does Knockout of ZNF771 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
ZNF771
|
cell proliferation
|
Cancer Cell Line
|
Gene: ZNF771 (zinc finger protein 771)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleolus, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q7L3S4
Entrez ID: 51333
|
Does Knockout of ELP5 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
ELP5
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ELP5 (elongator acetyltransferase complex subunit 5)
Type: protein-coding
Summary: Predicted to contribute to tRNA binding activity. Predicted to be involved in positive regulation of cell migration and tRNA modification. Located in cytosol and nucleoplasm. Part of elongator holoenzyme complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of cell migration, regulation of translation, tRNA modification, tRNA processing, tRNA wobble uridine modification; MF: protein binding, tRNA binding; CC: cytoplasm, cytosol, elongator holoenzyme complex, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q8TE02
Entrez ID: 23587
|
Does Knockout of WDR77 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
WDR77
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: WDR77 (WD repeat domain 77)
Type: protein-coding
Summary: The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: epithelial cell proliferation involved in prostate gland development, negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation involved in prostate gland development, oocyte axis specification, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of mRNA splicing, via spliceosome, protein polyubiquitination, regulation of transcription by RNA polymerase II, secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development, spliceosomal snRNP assembly, ubiquitin-dependent protein catabolic process; MF: methyl-CpG binding, protein binding, transcription coactivator activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul4B-RING E3 ubiquitin ligase complex, Golgi apparatus, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, transferase complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Metabolism of RNA, Metabolism of non-coding RNA, RMTs methylate histone arginines, Signaling events mediated by HDAC Class I, snRNP Assembly
UniProt: Q9BQA1
Entrez ID: 79084
|
Does Knockout of UQCC3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
UQCC3
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: UQCC3 (ubiquinol-cytochrome c reductase complex assembly factor 3)
Type: protein-coding
Summary: Complex III is a mitochondrial inner membrane protein complex that transfers electrons from ubiquinol to cytochrome c. This gene encodes a protein that functions in complex III assembly. Mutations in this gene result in Mitochondrial complex III deficiency, nuclear type 9. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: ATP biosynthetic process, cristae formation, mitochondrial electron transport, ubiquinol to cytochrome c, mitochondrial respiratory chain complex III assembly; MF: cardiolipin binding, phosphatidic acid binding; CC: cytosol, membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm
Pathways: Aerobic respiration and respiratory electron transport, Complex III assembly, Metabolism, Mitochondrial complex III assembly, Respiratory electron transport
UniProt: Q6UW78
Entrez ID: 790955
|
Does Knockout of PRLHR in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
PRLHR
|
response to virus
|
Lung Cancer Cell Line
|
Gene: PRLHR (prolactin releasing hormone receptor)
Type: protein-coding
Summary: PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, feeding behavior, female pregnancy, hormone metabolic process, neuropeptide signaling pathway, signal transduction; MF: G protein-coupled receptor activity, neuropeptide Y receptor activity, neuropeptide binding, neuropeptide receptor activity, protein binding; CC: cilium, membrane, neuron projection, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: P49683
Entrez ID: 2834
|
Does Knockout of KRT6A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
KRT6A
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: KRT6A (keratin 6A)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cell differentiation, defense response to Gram-positive bacterium, intermediate filament organization, keratinization, killing of cells of another organism, morphogenesis of an epithelium, negative regulation of entry of bacterium into host cell, positive regulation of cell population proliferation, wound healing; MF: protein binding, structural constituent of cytoskeleton, structural constituent of skin epidermis; CC: cytosol, extracellular exosome, intermediate filament, keratin filament, membrane, nucleus
Pathways: Developmental Biology, EGFR1, Ectoderm Differentiation, Formation of the cornified envelope, Keratinization
UniProt: P02538
Entrez ID: 3853
|
Does Knockout of SNAPC3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
SNAPC3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: SNAPC3 (small nuclear RNA activating complex polypeptide 3)
Type: protein-coding
Summary: Predicted to enable RNA polymerase III type 3 promoter sequence-specific DNA binding activity and bent DNA binding activity. Predicted to contribute to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and core promoter sequence-specific DNA binding activity. Predicted to be involved in snRNA transcription by RNA polymerase II and snRNA transcription by RNA polymerase III. Located in nuclear body and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: snRNA transcription, snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III, transcription by RNA polymerase II, transcription by RNA polymerase III; MF: DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase III general transcription initiation factor activity, RNA polymerase III type 3 promoter sequence-specific DNA binding, bent DNA binding, core promoter sequence-specific DNA binding, protein binding; CC: nuclear body, nucleolus, nucleoplasm, nucleus, snRNA-activating protein complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes
UniProt: Q92966
Entrez ID: 6619
|
Does Knockout of SLC10A2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
SLC10A2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SLC10A2 (solute carrier family 10 member 2)
Type: protein-coding
Summary: This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010].
Gene Ontology: BP: bile acid and bile salt transport, lipid transport, monoatomic ion transport, response to bacterium, sodium ion transport, transmembrane transport; MF: bile acid:sodium symporter activity, protein binding, symporter activity; CC: apical plasma membrane, membrane, microvillus, plasma membrane
Pathways: Bile acid and bile salt metabolism, Bile secretion - Homo sapiens (human), Metabolism, Metabolism of lipids, Metabolism of steroids, Recycling of bile acids and salts
UniProt: Q12908
Entrez ID: 6555
|
Does Knockout of U2AF1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
U2AF1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: U2AF1 (U2 small nuclear RNA auxiliary factor 1)
Type: protein-coding
Summary: This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, RS domain binding, metal ion binding, nucleic acid binding, pre-mRNA 3'-splice site binding, protein binding, zinc ion binding; CC: Cajal body, U2AF complex, catalytic step 2 spliceosome, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Shigellosis - Homo sapiens (human), Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, spliceosomal assembly
UniProt: Q01081
Entrez ID: 7307
|
Does Knockout of INTS4 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
INTS4
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: INTS4 (integrator complex subunit 4)
Type: protein-coding
Summary: INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, regulation of transcription elongation by RNA polymerase II, snRNA processing; MF: protein binding, protein-macromolecule adaptor activity; CC: INTAC complex, cytoplasm, integrator complex, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q96HW7
Entrez ID: 92105
|
Does Knockout of TRPM1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
TRPM1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: TRPM1 (transient receptor potential cation channel subfamily M member 1)
Type: protein-coding
Summary: This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: G protein-coupled glutamate receptor signaling pathway, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, cellular response to light stimulus, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, protein tetramerization, transmembrane transport, visual perception; MF: calcium channel activity, metal ion transmembrane transporter activity, monoatomic cation channel activity, monoatomic cation transmembrane transporter activity, monoatomic ion channel activity, protein binding; CC: axon, cell projection, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: 15q13.3 copy number variation syndrome, Developmental Biology, Ion channel transport, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Regulation of MITF-M-dependent genes involved in apoptosis, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q7Z4N2
Entrez ID: 4308
|
Does Knockout of PHYHIP in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
PHYHIP
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: PHYHIP (phytanoyl-CoA 2-hydroxylase interacting protein)
Type: protein-coding
Summary: Enables protein tyrosine kinase binding activity. Involved in protein localization. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, protein tyrosine kinase binding; CC: cytoplasm
Pathways:
UniProt: Q92561
Entrez ID: 9796
|
Does Knockout of FAU in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
FAU
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: FAU (FAU ubiquitin like and ribosomal protein S30 fusion)
Type: protein-coding
Summary: This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, cytoplasmic translation, defense response to Gram-positive bacterium, innate immune response in mucosa, modification-dependent protein catabolic process, protein ubiquitination, ribosomal small subunit assembly, translation; MF: RNA binding, protein binding, protein tag activity, structural constituent of ribosome, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular space, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62861
Entrez ID: 2197
|
Does Knockout of RPLP1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
RPLP1
|
cell proliferation
|
Cancer Cell Line
|
Gene: RPLP1 (ribosomal protein lateral stalk subunit P1)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, translation, translational elongation; MF: protein binding, protein kinase activator activity, ribonucleoprotein complex binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, focal adhesion, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P05386
Entrez ID: 6176
|
Does Knockout of RWDD4 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
RWDD4
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: RWDD4 (RWD domain containing 4)
Type: protein-coding
Summary: RWD domain containing 4
Gene Ontology:
Pathways:
UniProt: Q6NW29
Entrez ID: 201965
|
Does Knockout of POLR2K in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
POLR2K
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: POLR2K (RNA polymerase II, I and III subunit K)
Type: protein-coding
Summary: This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, regulation of transcription by RNA polymerase I, transcription by RNA polymerase II, transcription by RNA polymerase III; MF: DNA binding, DNA-directed RNA polymerase activity, metal ion binding, protein binding, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, RNA polymerase II, core complex, RNA polymerase III complex, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Abortive elongation of HIV-1 transcript in the absence of Tat, Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, B-WICH complex positively regulates rRNA expression, Cell Cycle, Chromosome Maintenance, Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , DNA Repair, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dual incision in TC-NER, ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, Eukaryotic Transcription Initiation, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene Silencing by RNA, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, HIV elongation arrest and recovery, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inhibition of DNA recombination at telomere, Innate Immune System, Late Phase of HIV Life Cycle, Metabolism of RNA, MicroRNA (miRNA) biogenesis, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, PIWI-interacting RNA (piRNA) biogenesis, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, Positive epigenetic regulation of rRNA expression, Processing of Capped Intron-Containing Pre-mRNA, Pyrimidine metabolism, RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Telomere Maintenance, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by small RNAs, Viral Infection Pathways, Viral Messenger RNA Synthesis, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P53803
Entrez ID: 5440
|
Does Knockout of CSMD3 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
CSMD3
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: CSMD3 (CUB and Sushi multiple domains 3)
Type: protein-coding
Summary: Predicted to be involved in regulation of dendrite development. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of dendrite development; CC: membrane, plasma membrane
Pathways: Head and Neck Squamous Cell Carcinoma
UniProt: Q7Z407
Entrez ID: 114788
|
Does Knockout of NOP56 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
NOP56
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: NOP56 (NOP56 ribonucleoprotein)
Type: protein-coding
Summary: Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, cadherin binding, histone methyltransferase binding, protein binding, snoRNA binding; CC: box C/D methylation guide snoRNP complex, cytoplasm, fibrillar center, membrane, nucleolus, nucleoplasm, nucleus, pre-snoRNP complex, ribonucleoprotein complex, small-subunit processome, sno(s)RNA-containing ribonucleoprotein complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Protein folding, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Spinocerebellar ataxia - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O00567
Entrez ID: 10528
|
Does Knockout of COPS6 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
COPS6
|
cell proliferation
|
Cancer Cell Line
|
Gene: COPS6 (COP9 signalosome subunit 6)
Type: protein-coding
Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: protein deneddylation, protein neddylation, regulation of protein neddylation; MF: metal-dependent deubiquitinase activity, peptidase activity, protein binding; CC: COP9 signalosome, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Cargo recognition for clathrin-mediated endocytosis, Ciliary landscape, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Nucleotide-binding Oligomerization Domain (NOD) pathway, Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q7L5N1
Entrez ID: 10980
|
Does Knockout of MTA2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
MTA2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: MTA2 (metastasis associated 1 family member 2)
Type: protein-coding
Summary: This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011].
Gene Ontology: BP: chromatin organization, chromatin remodeling, genomic imprinting, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell fate specification, regulation of fibroblast migration, regulation of stem cell differentiation; MF: DNA binding, DNA-binding transcription factor binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, histone deacetylase activity, histone deacetylase binding, metal ion binding, nucleosomal DNA binding, protein binding, sequence-specific DNA binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity, zinc ion binding; CC: NuRD complex, chromatin, chromosome, telomeric region, histone deacetylase complex, membrane, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: Adipogenesis, Chromatin modifying enzymes, Chromatin organization, Developmental Biology, Disease, EGFR1, ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression, Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome, Epigenetic regulation of gene expression, Gene expression (Transcription), Generic Transcription Pathway, HDACs deacetylate histones, Infectious disease, Intracellular signaling by second messengers, PIP3 activates AKT signaling, PTEN Regulation, Positive epigenetic regulation of rRNA expression, Potential therapeutics for SARS, RNA Polymerase I Promoter Clearance, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Acetylation, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins, Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs), SARS-CoV Infections, Signal Transduction, Signaling events mediated by HDAC Class I, Transcriptional Regulation by TP53, Transcriptional regulation of brown and beige adipocyte differentiation, Transcriptional regulation of brown and beige adipocyte differentiation by EBF2, Viral Infection Pathways
UniProt: O94776
Entrez ID: 9219
|
Does Knockout of PES1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
PES1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PES1 (pescadillo ribosomal biogenesis factor 1)
Type: protein-coding
Summary: This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: cell population proliferation, maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, regulation of cell cycle, ribosomal large subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding, ribonucleoprotein complex binding; CC: PeBoW complex, chromosome, cytosol, membrane, nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: O00541
Entrez ID: 23481
|
Does Knockout of HOXD8 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
HOXD8
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: HOXD8 (homeobox D8)
Type: protein-coding
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010].
Gene Ontology: BP: anterior/posterior axis specification, embryo, anterior/posterior pattern specification, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, skeletal system morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways: IL-18 signaling pathway
UniProt: P13378
Entrez ID: 3234
|
Does Knockout of SCYL1 in Lymphoma Cell Line causally result in cell proliferation?
| 1
| 646
|
Knockout
|
SCYL1
|
cell proliferation
|
Lymphoma Cell Line
|
Gene: SCYL1 (SCY1 like pseudokinase 1)
Type: protein-coding
Summary: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: inflammatory response, intracellular protein localization, neuron development, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, spinal cord motor neuron differentiation, vesicle-mediated transport; MF: ATP binding, DNA binding, cadherin binding, protein binding, protein kinase activity; CC: COPI vesicle coat, Golgi apparatus, centrosome, cis-Golgi network, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum-Golgi intermediate compartment, membrane, nucleus
Pathways:
UniProt: Q96KG9
Entrez ID: 57410
|
Does Knockout of ASCL4 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
ASCL4
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ASCL4 (achaete-scute family bHLH transcription factor 4)
Type: protein-coding
Summary: Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: animal organ development, epithelium development, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, skin development; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity; CC: RNA polymerase II transcription regulator complex, chromatin, nucleus, transcription regulator complex
Pathways:
UniProt: Q6XD76
Entrez ID: 121549
|
Does Knockout of ASIC5 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
ASIC5
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: ASIC5 (acid sensing ion channel subunit family member 5)
Type: protein-coding
Summary: This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, neuronal action potential, proton transmembrane transport, sodium ion import across plasma membrane, sodium ion transmembrane transport, sodium ion transport; MF: bile acid-gated sodium channel activity, ligand-gated sodium channel activity, proton channel activity, sodium channel activity; CC: apical plasma membrane, membrane, plasma membrane
Pathways: Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q9NY37
Entrez ID: 51802
|
Does Knockout of FCGR3B in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
FCGR3B
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: FCGR3B (Fc gamma receptor IIIb)
Type: protein-coding
Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: Fc-gamma receptor signaling pathway, antibody-dependent cellular cytotoxicity, cell surface receptor signaling pathway, immune response; MF: GPI anchor binding, IgG binding, IgG receptor activity; CC: external side of plasma membrane, extracellular exosome, extracellular region, membrane, plasma membrane, secretory granule membrane, side of membrane
Pathways: Fc gamma R-mediated phagocytosis - Homo sapiens (human), Immune System, Innate Immune System, Leishmaniasis - Homo sapiens (human), Metabolism of proteins, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Neutrophil degranulation, Neutrophil extracellular trap formation - Homo sapiens (human), Osteoclast differentiation - Homo sapiens (human), Phagosome - Homo sapiens (human), Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Staphylococcus aureus infection - Homo sapiens (human), Systemic lupus erythematosus - Homo sapiens (human), Tuberculosis - Homo sapiens (human), ras-independent pathway in nk cell-mediated cytotoxicity
UniProt: O75015
Entrez ID: 2215
|
Does Knockout of PRAF2 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
PRAF2
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PRAF2 (PRA1 domain family member 2)
Type: protein-coding
Summary: Predicted to be involved in L-glutamate transmembrane transport. Predicted to be located in endosome membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: L-glutamate transmembrane transport, protein transport; CC: GABA-ergic synapse, endosome, endosome membrane, glutamatergic synapse, membrane, postsynapse, presynapse
Pathways:
UniProt: O60831
Entrez ID: 11230
|
Does Knockout of SRY in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
SRY
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: SRY (sex determining region Y)
Type: protein-coding
Summary: This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, male sex determination, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of male gonad development, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, sex differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, calmodulin binding, protein binding; CC: chromatin, cytoplasm, nuclear speck, nucleoplasm, nucleus
Pathways: AndrogenReceptor, Deactivation of the beta-catenin transactivating complex, Developmental Biology, MAP3K1 role in promoting and blocking gonadal determination, Mammalian disorder of sexual development, Regulation of Androgen receptor activity, Signal Transduction, Signaling by WNT, Somatic sex determination, TCF dependent signaling in response to WNT, Transcriptional regulation of testis differentiation
UniProt: Q05066
Entrez ID: 6736
|
Does Knockout of FAM219B in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
FAM219B
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: FAM219B (family with sequence similarity 219 member B)
Type: protein-coding
Summary: family with sequence similarity 219 member B
Gene Ontology:
Pathways:
UniProt: Q5XKK7
Entrez ID: 57184
|
Does Knockout of DAPK2 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
DAPK2
|
response to chemicals
|
Melanoma Cell Line
|
Gene: DAPK2 (death associated protein kinase 2)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anoikis, apoptotic process, intracellular signal transduction, neutrophil migration, positive regulation of apoptotic process, positive regulation of eosinophil chemotaxis, positive regulation of neutrophil chemotaxis, protein autophosphorylation, protein phosphorylation, regulation of apoptotic process, regulation of autophagy, regulation of intrinsic apoptotic signaling pathway; MF: ATP binding, calmodulin binding, identical protein binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, autophagosome lumen, cytoplasm, cytoplasmic vesicle, nucleus
Pathways: Apoptosis, Autophagy - animal - Homo sapiens (human), Bladder cancer, Bladder cancer - Homo sapiens (human), Caspase activation via Dependence Receptors in the absence of ligand, Caspase activation via extrinsic apoptotic signalling pathway, Pathways in cancer - Homo sapiens (human), Programmed Cell Death
UniProt: Q9UIK4
Entrez ID: 23604
|
Does Knockout of TFR2 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
TFR2
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: TFR2 (transferrin receptor 2)
Type: protein-coding
Summary: This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011].
Gene Ontology: BP: cellular response to iron ion, endocytic iron import into cell, intracellular iron ion homeostasis, iron ion transport, multicellular organismal-level iron ion homeostasis, positive regulation of endocytosis, positive regulation of peptide hormone secretion, positive regulation of protein maturation, positive regulation of transcription by RNA polymerase II, receptor-mediated endocytosis, response to iron ion, transferrin transport; MF: co-receptor binding, protein binding, transferrin receptor activity; CC: HFE-transferrin receptor complex, cytoplasm, cytoplasmic vesicle, external side of plasma membrane, membrane, plasma membrane
Pathways: Iron metabolism in placenta, Iron uptake and transport, Transferrin endocytosis and recycling, Transport of small molecules
UniProt: Q9UP52
Entrez ID: 7036
|
Does Knockout of DYNLRB1 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
DYNLRB1
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: DYNLRB1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: microtubule-based movement, positive regulation of intracellular transport, visual behavior; MF: dynein intermediate chain binding, identical protein binding, microtubule motor activity, protein binding; CC: centrosome, ciliary tip, cilium, cytoplasm, cytoplasmic dynein complex, cytoskeleton, dynein complex, membrane, microtubule
Pathways: 3q29 copy number variation syndrome, Ciliary landscape, Cilium Assembly, Intraflagellar transport, Intraflagellar transport proteins binding to dynein, Organelle biogenesis and maintenance, Salmonella infection - Homo sapiens (human), TGF-beta receptor signaling, TGF_beta_Receptor
UniProt: Q9NP97
Entrez ID: 83658
|
Does Knockout of NUP88 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
NUP88
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: NUP88 (nucleoporin 88)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein import into nucleus, protein transport, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus; MF: protein binding, structural constituent of nuclear pore; CC: cytosol, nuclear envelope, nuclear pore, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q99567
Entrez ID: 4927
|
Does Knockout of COX18 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
COX18
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: COX18 (cytochrome c oxidase assembly factor COX18)
Type: protein-coding
Summary: This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly, protein insertion into membrane, protein insertion into mitochondrial inner membrane from matrix, protein insertion into mitochondrial membrane, respiratory chain complex IV assembly; MF: membrane insertase activity, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex IV assembly, Metabolism, Mitochondrial CIV Assembly, Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: Q8N8Q8
Entrez ID: 285521
|
Does Knockout of GRINA in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
GRINA
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1)
Type: protein-coding
Summary: Predicted to enable transmembrane transporter binding activity. Predicted to act upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic signaling pathway, calcium ion transmembrane transport, endoplasmic reticulum calcium ion homeostasis, negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of neuron apoptotic process; MF: calcium channel activity, protein binding, transmembrane transporter binding; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, membrane
Pathways:
UniProt: Q7Z429
Entrez ID: 2907
|
Does Knockout of FAM3D in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
FAM3D
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: FAM3D (FAM3 metabolism regulating signaling molecule D)
Type: protein-coding
Summary: Involved in negative regulation of insulin secretion. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: aorta development, negative regulation of insulin secretion, neutrophil homeostasis, neutrophil migration, positive regulation of macrophage antigen processing and presentation, signal transduction; MF: carbohydrate binding, cytokine activity, protein binding; CC: extracellular region, extracellular space
Pathways:
UniProt: Q96BQ1
Entrez ID: 131177
|
Does Knockout of DPH1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
DPH1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: DPH1 (diphthamide biosynthesis 1)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme involved in the biosynthesis of diphthamide, a modified histidine found only in elongation factor-2 (EEF2). Diphthamide residues in EEF2 are targeted for ADP-ribosylation by diphtheria toxin and Pseudomonas exotoxin A. Defects in this gene have been associated with both ovarian cancer and autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: fibroblast proliferation, protein histidyl modification to diphthamide; MF: 2-(3-amino-3-carboxypropyl)histidine synthase activity, 4 iron, 4 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding, protein binding, transferase activity; CC: 2-(3-amino-3-carboxypropyl)histidine synthase complex, cell junction, cytoplasm, cytosol, nucleoplasm, nucleus, protein-containing complex
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Metabolism of proteins, Post-translational protein modification, Synthesis of diphthamide-EEF2
UniProt: Q9BZG8
Entrez ID: 1801
|
Does Knockout of FUT9 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
FUT9
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: FUT9 (fucosyltransferase 9)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: L-fucose catabolic process, Lewis x epitope biosynthetic process, N-glycan fucosylation, carbohydrate metabolic process, fucosylation, glycosphingolipid biosynthetic process, lipid metabolic process, neuron differentiation, neuronal stem cell division, oligosaccharide biosynthetic process, polysaccharide biosynthetic process, positive regulation of neuron projection development, protein N-linked glycosylation, protein O-linked glycosylation, protein glycosylation, regulation of leukocyte cell-cell adhesion, regulation of leukocyte tethering or rolling, sphingolipid metabolic process; MF: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity, alpha-(1->3)-fucosyltransferase activity, fucosyltransferase activity, glycosyltransferase activity, protein binding, protein homodimerization activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane, trans-Golgi network, trans-Golgi network membrane
Pathways: Blood group systems biosynthesis, Globo Sphingolipid Metabolism, Glycosphingolipid biosynthesis - globo and isoglobo series - Homo sapiens (human), Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human), Lewis blood group biosynthesis, Mannose type O-glycan biosynthesis - Homo sapiens (human), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, terminal <i>O</i>-glycans residues modification
UniProt: Q9Y231
Entrez ID: 10690
|
Does Knockout of RALYL in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
RALYL
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: RALYL (RALY RNA binding protein like)
Type: protein-coding
Summary: Enables identical protein binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, identical protein binding, nucleic acid binding, protein binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q86SE5
Entrez ID: 138046
|
Does Knockout of MS4A5 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
MS4A5
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: MS4A5 (membrane spanning 4-domains A5)
Type: protein-coding
Summary: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. Though this member is not expressed in hematopoietic cells specifically, it may be involved in signal transduction like many of its related family members. The gene encoding this protein is localized to 11q12, among a cluster of family members. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q9H3V2
Entrez ID: 64232
|
Does Knockout of CGB8 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
CGB8
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: CGB8 (chorionic gonadotropin subunit beta 8)
Type: protein-coding
Summary: This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Glycoprotein hormones, Metabolism of proteins, Peptide hormone biosynthesis, Peptide hormone metabolism, RNA Polymerase II Transcription, TFAP2 (AP-2) family regulates transcription of growth factors and their receptors, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
UniProt: P0DN86
Entrez ID: 94115
|
Does Inhibition of RPTOR in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
RPTOR
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RPTOR (regulatory associated protein of MTOR complex 1)
Type: protein-coding
Summary: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: DNA damage response, TOR signaling, TORC1 signaling, autophagosome assembly, cellular response to L-leucine, cellular response to amino acid stimulus, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to nutrient levels, cellular response to osmotic stress, cellular response to starvation, cytoplasmic translation, negative regulation of autophagy, negative regulation of translational initiation, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of cell growth, positive regulation of endothelial cell proliferation, positive regulation of glycolytic process, positive regulation of lipid biosynthetic process, positive regulation of odontoblast differentiation, positive regulation of osteoclast differentiation, positive regulation of pentose-phosphate shunt, positive regulation of transcription by RNA polymerase III, positive regulation of translational initiation, protein localization to lysosome, regulation of autophagy, regulation of biological quality, regulation of cell communication, regulation of cell growth, regulation of cell size, regulation of signaling, response to xenobiotic stimulus, social behavior; MF: 14-3-3 protein binding, enzyme-substrate adaptor activity, protein binding, protein kinase activator activity, protein kinase binding, protein serine/threonine kinase inhibitor activity, protein-containing complex binding, protein-macromolecule adaptor activity, small GTPase binding; CC: TORC1 complex, cytoplasm, cytoplasmic stress granule, cytosol, dendrite, lysosomal membrane, lysosome, membrane, neuronal cell body, nucleoplasm, serine/threonine protein kinase complex
Pathways: AMP-activated protein kinase (AMPK) signaling, AMPK signaling pathway - Homo sapiens (human), Amino acids regulate mTORC1, Angiopoietin Like Protein 8 Regulatory Pathway, Autophagy, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), CAMKK2 Pathway, Cellular response to heat stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Energy dependent regulation of mTOR by LKB1-AMPK, Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Fragile X Syndrome, Gene expression (Transcription), Generic Transcription Pathway, HSF1-dependent transactivation, Head and Neck Squamous Cell Carcinoma, IL-18 signaling pathway, Insulin signaling pathway - Homo sapiens (human), Interferon type I signaling pathways, Intracellular signaling by second messengers, LKB1 signaling events, Longevity regulating pathway - Homo sapiens (human), Longevity regulating pathway - multiple species - Homo sapiens (human), MTOR signalling, Macroautophagy, MicroRNAs in cancer - Homo sapiens (human), Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, PI3K-AKT-mTOR signaling pathway and therapeutic opportunities, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PIP3 activates AKT signaling, PTEN Regulation, Pathways in clear cell renal cell carcinoma, RNA Polymerase II Transcription, Regulation of PTEN gene transcription, Regulatory circuits of the STAT3 signaling pathway, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Synaptic signaling pathways associated with autism spectrum disorder, TP53 Regulates Metabolic Genes, Target Of Rapamycin (TOR) Signaling, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, Transcriptional Regulation by TP53, Translation inhibitors in chronically activated PDGFRA cells, mTOR signaling pathway, mTOR signaling pathway - Homo sapiens (human), mTORC1-mediated signalling
UniProt: Q8N122
Entrez ID: 57521
|
Does Knockout of ST3GAL5 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
ST3GAL5
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5)
Type: protein-coding
Summary: Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ganglioside biosynthetic process, glycosphingolipid biosynthetic process, lipid metabolic process, protein glycosylation; MF: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity, glycosyltransferase activity, lactosylceramide alpha-2,3-sialyltransferase activity, sialyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Ganglio Sphingolipid Metabolism, Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human), Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Metabolism of proteins, Post-translational protein modification, Sialic acid metabolism, Sphingolipid metabolism, Synthesis of substrates in N-glycan biosythesis
UniProt: Q9UNP4
Entrez ID: 8869
|
Does Knockout of MAP4K1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
MAP4K1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1)
Type: protein-coding
Summary: Enables ATP binding activity and MAP kinase kinase kinase kinase activity. Involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphorylation. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: JNK cascade, cell population proliferation, cellular response to phorbol 13-acetate 12-myristate, intracellular signal transduction, peptidyl-serine phosphorylation, positive regulation of MAPK cascade, protein autophosphorylation, protein phosphorylation; MF: ATP binding, MAP kinase kinase kinase kinase activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, membrane
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, B Cell Receptor Signaling Pathway, BCR signaling pathway, Cardiac Hypertrophic Response, EGF-EGFR signaling pathway, Hippo-Yap signaling pathway, Insulin Signaling, JNK signaling in the CD4+ TCR pathway, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Modulators of TCR signaling and T cell activation, Signaling events mediated by Stem cell factor receptor (c-Kit), Signaling of Hepatocyte Growth Factor Receptor, T-cell receptor (TCR) signaling pathway, TCR, TCR signaling in naïve CD4+ T cells, TGF-beta Signaling Pathway, TGF_beta_Receptor, mapkinase signaling pathway
UniProt: Q92918
Entrez ID: 11184
|
Does Knockout of SLC35E3 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
SLC35E3
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: SLC35E3 (solute carrier family 35 member E3)
Type: protein-coding
Summary: Predicted to enable antiporter activity and nucleotide-sugar transmembrane transporter activity. Predicted to be involved in carbohydrate derivative transport; nucleobase-containing compound transport; and transmembrane transport. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: carbohydrate derivative transport, nucleobase-containing compound transport, organophosphate ester transport, transmembrane transport; MF: antiporter activity, nucleotide-sugar transmembrane transporter activity, protein binding; CC: Golgi apparatus, membrane
Pathways:
UniProt: Q7Z769
Entrez ID: 55508
|
Does Knockout of MCOLN3 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
MCOLN3
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: MCOLN3 (mucolipin TRP cation channel 3)
Type: protein-coding
Summary: This gene encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: calcium ion transmembrane transport, calcium-mediated signaling, inner ear auditory receptor cell differentiation, locomotory behavior, monoatomic anion transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, sodium ion transmembrane transport; MF: NAADP-sensitive calcium-release channel activity, calcium channel activity, lipid binding, monoatomic anion channel activity, monoatomic cation channel activity, potassium channel activity, sodium channel activity; CC: autophagosome membrane, cytoplasm, cytoplasmic vesicle, early endosome membrane, endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, plasma membrane
Pathways: Calcium signaling pathway - Homo sapiens (human), Ion channel transport, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q8TDD5
Entrez ID: 55283
|
Does Knockout of METTL6 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
METTL6
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: METTL6 (methyltransferase 6, tRNA N3-cytidine)
Type: protein-coding
Summary: Enables enzyme binding activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: methylation, tRNA methylation, tRNA modification, tRNA processing; MF: enzyme binding, methyltransferase activity, protein binding, tRNA (cytidine-3-)-methyltransferase activity, transferase activity; CC: cytoplasm, nucleus
Pathways: Selenoamino Acid Metabolism
UniProt: Q8TCB7
Entrez ID: 131965
|
Does Knockout of KCNK10 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
KCNK10
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: KCNK10 (potassium two pore domain channel subfamily K member 10)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008].
Gene Ontology: BP: cellular response to arachidonate, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, signal transduction; MF: mechanosensitive potassium channel activity, outward rectifier potassium channel activity, potassium channel activity, potassium ion leak channel activity; CC: membrane, monoatomic ion channel complex, plasma membrane
Pathways: Cardiac conduction, Ectoderm Differentiation, Gastric acid secretion - Homo sapiens (human), Muscle contraction, Neuronal System, Phase 4 - resting membrane potential, Potassium Channels, TWIK related potassium channel (TREK), Tandem pore domain potassium channels
UniProt: P57789
Entrez ID: 54207
|
Does Knockout of GUF1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
GUF1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GUF1 (GTP binding elongation factor GUF1)
Type: protein-coding
Summary: This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitates tRNA binding. The encoded protein is thought to prevent misincorporation of amino acids in stressful, suboptimal conditions. An allelic variant in this gene has been associated with early infantile epileptic encephalopathy-40. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: positive regulation of translation, translation; MF: GTP binding, GTPase activity, hydrolase activity, mitochondrial ribosome binding, nucleotide binding, ribosome binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q8N442
Entrez ID: 60558
|
Does Knockout of MFSD6L in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
MFSD6L
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MFSD6L (major facilitator superfamily domain containing 6 like)
Type: protein-coding
Summary: Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane
Pathways:
UniProt: Q8IWD5
Entrez ID: 162387
|
Does Knockout of LMNB1 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
LMNB1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: LMNB1 (lamin B1)
Type: protein-coding
Summary: This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: cytoskeleton organization, heterochromatin formation, nuclear envelope organization, nuclear migration, nuclear pore localization, protein localization to nuclear envelope; MF: double-stranded DNA binding, phospholipase binding, protein binding, sequence-specific double-stranded DNA binding, structural constituent of cytoskeleton, structural constituent of nuclear lamina; CC: intermediate filament, lamin filament, membrane, nuclear envelope, nuclear inner membrane, nuclear lamina, nuclear matrix, nuclear membrane, nuclear periphery, nucleoplasm, nucleus
Pathways: Apoptosis - Homo sapiens (human), Caspase Cascade in Apoptosis, Fas ligand pathway and stress induction of heat shock proteins, caspase cascade in apoptosis, hiv-1 nef: negative effector of fas and tnf, tnfr1 signaling pathway
UniProt: P20700
Entrez ID: 4001
|
Does Knockout of CLSPN in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
CLSPN
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CLSPN (claspin)
Type: protein-coding
Summary: The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, DNA replication checkpoint signaling, activation of protein kinase activity, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, peptidyl-serine phosphorylation; MF: DNA binding, DNA secondary structure binding, anaphase-promoting complex binding, protein binding; CC: Golgi apparatus, nucleoplasm, nucleus
Pathways: ATR signaling pathway, Activation of ATR in response to replication stress, Apoptosis, Apoptotic cleavage of cellular proteins, Apoptotic execution phase, Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Metabolism of proteins, PLK1 signaling events, Post-translational protein modification, Processing of DNA double-strand break ends, Programmed Cell Death, Ub-specific processing proteases
UniProt: Q9HAW4
Entrez ID: 63967
|
Does Knockout of SEMG1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
SEMG1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: SEMG1 (semenogelin 1)
Type: protein-coding
Summary: The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, coagulation, insemination, killing of cells of another organism, negative regulation of calcium ion import, negative regulation of flagellated sperm motility, positive regulation of serine-type endopeptidase activity, sperm capacitation; MF: protein binding, zinc ion binding; CC: acrosomal vesicle, extracellular exosome, extracellular region, extracellular space, nucleus, protein-containing complex
Pathways: Male infertility
UniProt: P04279
Entrez ID: 6406
|
Does Knockout of ADNP in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
ADNP
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: ADNP (activity dependent neuroprotector homeobox)
Type: protein-coding
Summary: Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cGMP-mediated signaling, estrous cycle, intracellular nitric oxide homeostasis, negative regulation of gene expression, negative regulation of neuron apoptotic process, negative regulation of synaptic transmission, neuron apoptotic process, neuron differentiation, positive regulation of axon extension, positive regulation of canonical Wnt signaling pathway, positive regulation of neuron projection development, positive regulation of synapse assembly, regulation of gene expression, regulation of transcription by RNA polymerase II, response to carbohydrate, short-term memory; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, beta-catenin binding, beta-tubulin binding, chromatin binding, copper ion binding, metal ion binding, peptide binding, protein binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, axon, chromatin, chromosome, dendrite, extracellular space, neuronal cell body, nucleus
Pathways:
UniProt: Q9H2P0
Entrez ID: 23394
|
Does Knockout of RBL1 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 1
| 1,480
|
Knockout
|
RBL1
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: RBL1 (RB transcriptional corepressor like 1)
Type: protein-coding
Summary: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, chromatin organization, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of cellular senescence, negative regulation of gene expression, negative regulation of macromolecule biosynthetic process, negative regulation of transcription by RNA polymerase II, regulation of cell cycle, regulation of gene expression, regulation of lipid kinase activity, regulation of transcription by RNA polymerase II; MF: RNA polymerase II transcription regulatory region sequence-specific DNA binding, promoter-specific chromatin binding, protein binding; CC: chromatin, nucleoplasm, nucleus, transcription regulator complex
Pathways: Adipogenesis, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Cyclin D associated events in G1, E2F transcription factor network, FGFR3 signaling in chondrocyte proliferation and terminal differentiation, G0 and Early G1, G1 Phase, G1/S Transition, G1/S-Specific Transcription, Gene expression (Transcription), Generic Transcription Pathway, Human papillomavirus infection - Homo sapiens (human), ID, ID signaling pathway, Mitotic G1 phase and G1/S transition, RNA Polymerase II Transcription, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta Signaling Pathway, TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Transcription of E2F targets under negative control by DREAM complex, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1, Transcriptional Regulation by TP53, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Validated targets of C-MYC transcriptional repression, Viral carcinogenesis - Homo sapiens (human), cyclins and cell cycle regulation, mets affect on macrophage differentiation
UniProt: P28749
Entrez ID: 5933
|
Does Knockout of KAT7 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
KAT7
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: KAT7 (lysine acetyltransferase 7)
Type: protein-coding
Summary: The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication-dependent chromatin disassembly, T cell differentiation, chromatin organization, internal peptidyl-lysine acetylation, natural killer cell differentiation, positive regulation of DNA replication, positive regulation of DNA-templated transcription, elongation, positive regulation of erythrocyte differentiation, positive regulation of hematopoietic stem cell proliferation, positive regulation of nucleobase-containing compound metabolic process, positive regulation of protein localization to nucleus, positive regulation of transcription by RNA polymerase II, regulation of DNA biosynthetic process, regulation of DNA replication, regulation of DNA-templated DNA replication initiation, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell growth, regulation of nucleotide-excision repair, regulation of transcription by RNA polymerase II, response to actinomycin D, response to anisomycin, response to dithiothreitol, response to hydroxyurea, response to sorbitol, stress-activated protein kinase signaling cascade, transcription initiation-coupled chromatin remodeling; MF: DNA replication origin binding, acyltransferase activity, chromatin binding, histone H3 acetyltransferase activity, histone H3K14 acetyltransferase activity, histone H3K23 acetyltransferase activity, histone H3K4 acetyltransferase activity, histone H4 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone H4K16 acetyltransferase activity, histone H4K5 acetyltransferase activity, histone H4K8 acetyltransferase activity, histone acetyltransferase activity, metal ion binding, protein binding, transcription coregulator activity, transferase activity, zinc ion binding; CC: chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytosol, histone H3-K14 acetyltransferase complex, histone acetyltransferase complex, nucleolus, nucleoplasm, nucleus, site of DNA damage
Pathways: Androgen receptor signaling pathway, AndrogenReceptor, Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, Regulation of Androgen receptor activity
UniProt: O95251
Entrez ID: 11143
|
Does Knockout of WDR33 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
WDR33
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: WDR33 (WD repeat domain 33)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mRNA 3'-end processing, mRNA processing, postreplication repair, spermatogenesis; CC: collagen trimer, fibrillar center, mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9C0J8
Entrez ID: 55339
|
Does Knockout of SOD1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
SOD1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: SOD1 (superoxide dismutase 1)
Type: protein-coding
Summary: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2020].
Gene Ontology: BP: action potential initiation, anterograde axonal transport, apoptotic process, auditory receptor cell stereocilium organization, cellular response to ATP, cellular response to cadmium ion, cellular response to oxidative stress, cellular response to potassium ion, determination of adult lifespan, ectopic germ cell programmed cell death, embryo implantation, gene expression, glutathione metabolic process, heart contraction, hydrogen peroxide biosynthetic process, intracellular iron ion homeostasis, locomotory behavior, muscle cell cellular homeostasis, myeloid cell homeostasis, negative regulation of apoptotic process, negative regulation of developmental process, negative regulation of inflammatory response, negative regulation of neuron apoptotic process, negative regulation of reproductive process, neurofilament cytoskeleton organization, neuronal action potential, ovarian follicle development, peripheral nervous system myelin maintenance, placenta development, positive regulation of MAPK cascade, positive regulation of apoptotic process, positive regulation of cytokine production, positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, positive regulation of phagocytosis, positive regulation of superoxide anion generation, reactive oxygen species metabolic process, regulation of GTPase activity, regulation of T cell differentiation in thymus, regulation of blood pressure, regulation of mitochondrial membrane potential, regulation of multicellular organism growth, regulation of organ growth, relaxation of vascular associated smooth muscle, removal of superoxide radicals, response to amphetamine, response to antipsychotic drug, response to axon injury, response to carbon monoxide, response to copper ion, response to ethanol, response to heat, response to hydrogen peroxide, response to nutrient levels, response to oxidative stress, response to reactive oxygen species, response to superoxide, response to xenobiotic stimulus, retina homeostasis, retrograde axonal transport, sensory perception of sound, spermatogenesis, superoxide anion generation, superoxide metabolic process, thymus development, transmission of nerve impulse; MF: antioxidant activity, copper ion binding, enzyme binding, identical protein binding, metal ion binding, oxidoreductase activity, protein binding, protein homodimerization activity, protein phosphatase 2B binding, protein-folding chaperone binding, small GTPase binding, superoxide dismutase activity, zinc ion binding; CC: axon cytoplasm, cytoplasm, cytoplasmic vesicle, cytosol, dendrite cytoplasm, dense core granule, extracellular exosome, extracellular region, extracellular space, lysosome, mitochondrial intermembrane space, mitochondrial matrix, mitochondrion, neuronal cell body, nucleoplasm, nucleus, peroxisome, plasma membrane, protein-containing complex, secretory granule
Pathways: AGE-RAGE pathway, Amyotrophic lateral sclerosis (ALS), Amyotrophic lateral sclerosis - Homo sapiens (human), Association Between Physico-Chemical Features and Toxicity Associated Pathways, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Copper homeostasis, Cytokine Signaling in Immune system, Degradation of Superoxides, Detoxification of Reactive Oxygen Species, Dopamine metabolism, Extracellular vesicles in the crosstalk of cardiac cells, FOXA1 transcription factor network, Folate Metabolism, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Hemostasis, Huntington disease - Homo sapiens (human), IL1, Immune System, Interleukin-12 family signaling, Interleukin-12 signaling, Longevity regulating pathway - multiple species - Homo sapiens (human), One-carbon metabolism and related pathways, Oxidative Stress, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Peroxisome - Homo sapiens (human), Platelet activation, signaling and aggregation, Platelet degranulation , Prion disease - Homo sapiens (human), Response to elevated platelet cytosolic Ca2+, Selenium Micronutrient Network, Signaling by Interleukins, Validated nuclear estrogen receptor alpha network, Vitamin B12 metabolism, cardiac protection against ros, superoxide radicals degradation, the igf-1 receptor and longevity
UniProt: P00441
Entrez ID: 6647
|
Does Knockout of C11orf52 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
C11orf52
|
cell proliferation
|
Cancer Cell Line
|
Gene: C11orf52 (chromosome 11 open reading frame 52)
Type: protein-coding
Summary: Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: EGFR1
UniProt: Q96A22
Entrez ID: 91894
|
Does Knockout of MAGEA10 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
MAGEA10
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: MAGEA10 (MAGE family member A10)
Type: protein-coding
Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011].
Gene Ontology: CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: P43363
Entrez ID: 4109
|
Does Knockout of HELB in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
HELB
|
response to virus
|
Hepatoma Cell Line
|
Gene: HELB (DNA helicase B)
Type: protein-coding
Summary: This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S phase entry of the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, DNA replication, synthesis of primer, DNA-templated DNA replication, negative regulation of double-strand break repair via homologous recombination, regulation of DNA double-strand break processing; MF: 5'-3' DNA helicase activity, ATP binding, ATP hydrolysis activity, DNA helicase activity, helicase activity, hydrolase activity, nucleotide binding, protein-containing complex binding, single-stranded DNA helicase activity; CC: DNA replication factor A complex, chromosome, cytoplasm, cytosol, mitochondrion, nuclear body, nucleoplasm, nucleus, site of double-strand break
Pathways:
UniProt: Q8NG08
Entrez ID: 92797
|
Does Knockout of AK2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
AK2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: AK2 (adenylate kinase 2)
Type: protein-coding
Summary: Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010].
Gene Ontology: BP: ADP biosynthetic process, AMP metabolic process, ATP metabolic process, nucleobase-containing compound metabolic process, nucleobase-containing small molecule interconversion, nucleoside monophosphate metabolic process, nucleoside monophosphate phosphorylation, nucleotide metabolic process; MF: AMP kinase activity, ATP binding, kinase activity, nucleobase-containing compound kinase activity, nucleotide binding, phosphotransferase activity, phosphate group as acceptor, protein binding, transferase activity; CC: cytoplasm, extracellular exosome, mitochondrial intermembrane space, mitochondrion, sperm flagellum, sperm mitochondrial sheath
Pathways: Adefovir Dipivoxil Metabolism Pathway, Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Purine metabolism - Homo sapiens (human), Tenofovir Metabolism Pathway, Thiamine metabolism - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: P54819
Entrez ID: 204
|
Does Knockout of SEPHS1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
SEPHS1
|
cell proliferation
|
Cancer Cell Line
|
Gene: SEPHS1 (selenophosphate synthetase 1)
Type: protein-coding
Summary: This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: protein modification process, selenocysteine biosynthetic process; MF: ATP binding, GTP binding, identical protein binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein heterodimerization activity, protein homodimerization activity, selenide, water dikinase activity, transferase activity; CC: cytoplasm, membrane, nuclear membrane, nucleus, plasma membrane
Pathways: Selenocompound metabolism - Homo sapiens (human), selenocysteine biosynthesis
UniProt: P49903
Entrez ID: 22929
|
Does Knockout of SCN2A in Prostate Cancer Cell Line causally result in response to chemicals?
| 1
| 2,109
|
Knockout
|
SCN2A
|
response to chemicals
|
Prostate Cancer Cell Line
|
Gene: SCN2A (sodium voltage-gated channel alpha subunit 2)
Type: protein-coding
Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].
Gene Ontology: BP: action potential, cardiac muscle cell action potential involved in contraction, cellular response to hypoxia, intrinsic apoptotic signaling pathway in response to osmotic stress, memory, monoatomic ion transmembrane transport, monoatomic ion transport, myelination, nervous system development, neuron apoptotic process, neuronal action potential, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: calmodulin binding, monoatomic cation channel activity, monoatomic ion channel activity, protein binding, sodium channel activity, voltage-gated sodium channel activity; CC: axon, membrane, monoatomic ion channel complex, node of Ranvier, plasma membrane, voltage-gated sodium channel complex
Pathways: Axon guidance, Cardiac conduction, Developmental Biology, Interaction between L1 and Ankyrins, L1CAM interactions, Muscle contraction, Nervous system development, Phase 0 - rapid depolarisation, Rett syndrome causing genes, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Taste transduction - Homo sapiens (human)
UniProt: Q99250
Entrez ID: 6326
|
Does Knockout of PSMA1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
PSMA1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: PSMA1 (proteasome 20S subunit alpha 1)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009].
Gene Ontology: BP: immune system process, negative regulation of inflammatory response to antigenic stimulus, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: lipopolysaccharide binding, protein binding; CC: centrosome, cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), proteasome complex
UniProt: P25786
Entrez ID: 5682
|
Does Knockout of AHCY in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
AHCY
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: AHCY (adenosylhomocysteinase)
Type: protein-coding
Summary: S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].
Gene Ontology: BP: S-adenosylmethionine cycle, one-carbon metabolic process; MF: adenosylhomocysteinase activity, hydrolase activity, protein binding; CC: cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, melanosome, nucleus
Pathways: Betaine Metabolism, Biological oxidations, Cystathionine Beta-Synthase Deficiency, Cysteine and methionine metabolism - Homo sapiens (human), Defective AHCY causes HMAHCHD, Disease, Diseases of metabolism, Ethanol effects on histone modifications, Folate Metabolism, Glycine N-methyltransferase Deficiency, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, Metabolic disorders of biological oxidation enzymes, Metabolism, Metabolism of amino acids and derivatives, Metabolism of ingested SeMet, Sec, MeSec into H2Se, Methionine Adenosyltransferase Deficiency, Methionine De Novo and Salvage Pathway, Methionine Metabolism, Methylation, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), One-carbon metabolism, Phase II - Conjugation of compounds, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, Selenoamino Acid Metabolism, Selenoamino acid metabolism, Sulfur amino acid metabolism, TCR, Trans-sulfuration and one-carbon metabolism, Trans-sulfuration pathway, cysteine biosynthesis, methionine degradation, superpathway of methionine degradation
UniProt: P23526
Entrez ID: 191
|
Does Knockout of RHOT2 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
RHOT2
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: RHOT2 (ras homolog family member T2)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: cellular homeostasis, mitochondrial outer membrane permeabilization, mitochondrion organization, mitochondrion transport along microtubule; MF: ATP hydrolysis activity, GDP binding, GTP binding, GTPase activity, calcium ion binding, hydrolase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding; CC: membrane, mitochondrial outer membrane, mitochondrion
Pathways: Miro GTPase Cycle, Mitophagy - animal - Homo sapiens (human), RHOT2 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8IXI1
Entrez ID: 89941
|
Does Knockout of PRAMEF5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
PRAMEF5
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PRAMEF5 (PRAME family member 5)
Type: protein-coding
Summary: Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: Q5TYX0
Entrez ID: 343068
|
Does Knockout of OR5D16 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
OR5D16
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: OR5D16 (olfactory receptor family 5 subfamily D member 16)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGK9
Entrez ID: 390144
|
Does Knockout of KIF2A in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
KIF2A
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: KIF2A (kinesin family member 2A)
Type: protein-coding
Summary: The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: cell differentiation, cell division, microtubule cytoskeleton organization, microtubule depolymerization, microtubule-based movement, mitotic sister chromatid segregation, mitotic spindle assembly, mitotic spindle organization, nervous system development, regulation of cell migration; MF: ATP binding, ATP hydrolysis activity, cytoskeletal motor activity, microtubule binding, microtubule motor activity, nucleotide binding, protein binding; CC: centriolar subdistal appendage, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, kinesin complex, membrane, microtubule, mitotic spindle, nuclear body, nucleolus, nucleoplasm, spindle, spindle microtubule, spindle pole
Pathways: Adaptive Immune System, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, COPI-dependent Golgi-to-ER retrograde traffic, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, M Phase, MHC class II antigen presentation, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, PLK1 signaling events, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Vesicle-mediated transport
UniProt: O00139
Entrez ID: 3796
|
Does Knockout of PHF5A in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
PHF5A
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PHF5A (PHD finger protein 5A)
Type: protein-coding
Summary: This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, positive regulation of DNA-templated transcription, stem cell differentiation; MF: DNA binding, RNA binding, metal ion binding, protein binding, zinc ion binding; CC: U12-type spliceosomal complex, U2 snRNP, U2-type precatalytic spliceosome, U2-type spliceosomal complex, nuclear matrix, nuclear speck, nucleoplasm, nucleus, precatalytic spliceosome, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q7RTV0
Entrez ID: 84844
|
Does Knockout of EMC1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
EMC1
|
cell proliferation
|
Cancer Cell Line
|
Gene: EMC1 (ER membrane protein complex subunit 1)
Type: protein-coding
Summary: This gene encodes a single-pass type I transmembrane protein, which is a subunit of the endoplasmic reticulum membrane protein complex (EMC). Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2012].
Gene Ontology: BP: protein insertion into ER membrane by stop-transfer membrane-anchor sequence, tail-anchored membrane protein insertion into ER membrane; MF: membrane insertase activity, protein binding; CC: EMC complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, protein-containing complex
Pathways:
UniProt: Q8N766
Entrez ID: 23065
|
Does Knockout of OR51A7 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
OR51A7
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: OR51A7 (olfactory receptor family 51 subfamily A member 7)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to lipid, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction, system process; MF: G protein-coupled receptor activity, olfactory receptor activity, signaling receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NH64
Entrez ID: 119687
|
Does Knockout of TRIM11 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
TRIM11
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TRIM11 (tripartite motif containing 11)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: defense response to virus, host-mediated suppression of symbiont invasion, innate immune response, negative regulation of AIM2 inflammasome complex assembly, negative regulation of DNA-templated transcription, negative regulation of neurogenesis, negative regulation of viral transcription, positive regulation of viral entry into host cell, protein autoubiquitination, protein ubiquitination, regulation of gene expression, suppression of viral release by host; MF: metal ion binding, protein binding, protein domain specific binding, protein-macromolecule adaptor activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System
UniProt: Q96F44
Entrez ID: 81559
|
Does Knockout of HNRNPUL2 in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
HNRNPUL2
|
response to virus
|
Lung Cancer Cell Line
|
Gene: HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U like 2)
Type: protein-coding
Summary: Enables RNA binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding; CC: membrane, nucleoplasm, nucleus, synapse
Pathways:
UniProt: Q1KMD3
Entrez ID: 221092
|
Does Knockout of CDC27 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
CDC27
|
cell proliferation
|
Melanoma Cell Line
|
Gene: CDC27 (cell division cycle 27)
Type: protein-coding
Summary: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, metaphase/anaphase transition of mitotic cell cycle, neuron projection development, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; MF: protein binding, protein phosphatase binding; CC: anaphase-promoting complex, centrosome, cytoplasm, cytoskeleton, cytosol, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: Cell cycle, Cell cycle - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), TGF_beta_Receptor, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: P30260
Entrez ID: 996
|
Does Knockout of P2RX6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
P2RX6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: P2RX6 (purinergic receptor P2X 6)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009].
Gene Ontology: BP: calcium ion transmembrane transport, excitatory postsynaptic potential, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, muscle contraction, purinergic nucleotide receptor signaling pathway, response to ATP, signal transduction; MF: ATP binding, channel activity, extracellularly ATP-gated monoatomic cation channel activity, monoatomic ion channel activity, protein-containing complex binding, purinergic nucleotide receptor activity, transmembrane signaling receptor activity; CC: cell junction, cytoplasm, dendritic spine, endoplasmic reticulum, endoplasmic reticulum membrane, glutamatergic synapse, membrane, neuronal cell body, nuclear inner membrane, nucleus, parallel fiber to Purkinje cell synapse, plasma membrane, postsynaptic specialization membrane, receptor complex
Pathways: 22q11.2 copy number variation syndrome, Calcium signaling pathway - Homo sapiens (human), Elevation of cytosolic Ca2+ levels, Hemostasis, Neuroactive ligand-receptor interaction - Homo sapiens (human), Platelet calcium homeostasis, Platelet homeostasis, Purinergic signaling
UniProt: O15547
Entrez ID: 9127
|
Does Knockout of DHX33 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
DHX33
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: DHX33 (DEAH-box helicase 33)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: positive regulation of MAPK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of transcription by RNA polymerase I, positive regulation of type I interferon production, translational initiation; MF: ATP binding, ATP hydrolysis activity, DNA-binding transcription factor binding, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding, rDNA binding, ribosomal large subunit binding; CC: NLRP3 inflammasome complex, canonical inflammasome complex, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: NOD-like receptor signaling pathway - Homo sapiens (human)
UniProt: Q9H6R0
Entrez ID: 56919
|
Does Knockout of PPA2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
PPA2
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: PPA2 (inorganic pyrophosphatase 2)
Type: protein-coding
Summary: The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: diphosphate metabolic process, phosphate-containing compound metabolic process, regulation of mitochondrial membrane potential; MF: hydrolase activity, inorganic diphosphate phosphatase activity, magnesium ion binding, metal ion binding, protein binding, protein serine/threonine phosphatase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion, synapse
Pathways: Oxidative phosphorylation - Homo sapiens (human)
UniProt: Q9H2U2
Entrez ID: 27068
|
Does Knockout of RAD51 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
RAD51
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RAD51 (RAD51 recombinase)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA recombinase assembly, DNA recombination, DNA repair, DNA strand invasion, cellular response to alkaloid, cellular response to camptothecin, cellular response to cisplatin, cellular response to gamma radiation, cellular response to hydroxyurea, cellular response to ionizing radiation, chromosome organization involved in meiotic cell cycle, double-strand break repair involved in meiotic recombination, double-strand break repair via homologous recombination, interstrand cross-link repair, meiosis I, meiotic cell cycle, mitotic recombination, mitotic recombination-dependent replication fork processing, reciprocal meiotic recombination, regulation of DNA damage checkpoint, regulation of double-strand break repair via homologous recombination, replication fork processing, replication-born double-strand break repair via sister chromatid exchange, response to X-ray, response to glucoside, response to toxic substance, response to xenobiotic stimulus, telomere maintenance via recombination, telomere maintenance via telomere lengthening, telomere organization; MF: ATP binding, ATP-dependent DNA damage sensor activity, ATP-dependent activity, acting on DNA, DNA binding, DNA polymerase binding, DNA strand exchange activity, chromatin binding, double-stranded DNA binding, enzyme binding, identical protein binding, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: PML body, centrosome, chromatin, chromosome, chromosome, telomeric region, condensed chromosome, condensed nuclear chromosome, cytoplasm, cytoskeleton, cytosol, lateral element, male germ cell nucleus, mitochondrial matrix, mitochondrion, nuclear chromosome, nuclear ubiquitin ligase complex, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, presynaptic intermediate filament cytoskeleton, protein-containing complex, site of double-strand break
Pathways: ATM Signaling Pathway, ATR signaling pathway, BARD1 signaling events, Breast cancer pathway, DNA Repair Pathways Full Network, DNA damage response, Fanconi anemia pathway - Homo sapiens (human), Homologous recombination, Homologous recombination - Homo sapiens (human), Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, atm signaling pathway, miRNA regulation of DNA damage response, p73 transcription factor network, role of brca1 brca2 and atr in cancer susceptibility
UniProt: Q06609
Entrez ID: 5888
|
Does Knockout of HEPH in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
HEPH
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: HEPH (hephaestin)
Type: protein-coding
Summary: This gene encodes a member of the multicopper oxidase protein family. The encoded protein is involved in the transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system, and may be involved in copper transport and homeostasis. In mouse, defects in this gene can lead to severe microcytic anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: intestinal iron absorption, iron ion transport, monoatomic ion transport, multicellular organismal-level iron ion homeostasis, positive regulation of iron export across plasma membrane; MF: copper ion binding, ferroxidase activity, metal ion binding, oxidoreductase activity, protein binding; CC: basolateral plasma membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Mineral absorption - Homo sapiens (human), Porphyrin and chlorophyll metabolism - Homo sapiens (human)
UniProt: Q9BQS7
Entrez ID: 9843
|
Does Knockout of PRSS48 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
PRSS48
|
cell proliferation
|
Melanoma Cell Line
|
Gene: PRSS48 (serine protease 48)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: proteolysis; MF: hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q7RTY5
Entrez ID: 345062
|
Does Knockout of FAM234A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
FAM234A
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: FAM234A (family with sequence similarity 234 member A)
Type: protein-coding
Summary: Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell surface, extracellular exosome, membrane
Pathways:
UniProt: Q9H0X4
Entrez ID: 83986
|
Does Knockout of HOXB5 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
HOXB5
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: HOXB5 (homeobox B5)
Type: protein-coding
Summary: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anatomical structure morphogenesis, anterior/posterior pattern specification, embryonic skeletal system development, embryonic skeletal system morphogenesis, endothelial cell differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytosol, fibrillar center, nucleoplasm, nucleus
Pathways:
UniProt: P09067
Entrez ID: 3215
|
Does Knockout of SNRNP25 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
SNRNP25
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SNRNP25 (small nuclear ribonucleoprotein U11/U12 subunit 25)
Type: protein-coding
Summary: Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U12-type spliceosome is found in some eukaryotes and removes U12-type introns, which are rare and have distinct splice consensus signals. The U12-type spliceosome consists of several small nuclear RNAs and associated proteins. This gene encodes a 25K protein that is a component of the U12-type spliceosome. [provided by RefSeq, Apr 2010].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; CC: U12-type spliceosomal complex, cytosol, intercellular bridge, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Minor Pathway
UniProt: Q9BV90
Entrez ID: 79622
|
Does Knockout of FOXM1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
FOXM1
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: FOXM1 (forkhead box M1)
Type: protein-coding
Summary: The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, G2/M transition of mitotic cell cycle, negative regulation of DNA-templated transcription, negative regulation of stress-activated MAPK cascade, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of double-strand break repair, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of Ras protein signal transduction, regulation of cell cycle, regulation of cell population proliferation, regulation of mitotic cell cycle, regulation of reactive oxygen species metabolic process, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein kinase binding, sequence-specific DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cellular senescence - Homo sapiens (human), Cyclin A/B1/B2 associated events during G2/M transition, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Epithelial to mesenchymal transition in colorectal cancer, FOXM1 transcription factor network, G2/M Transition, Hippo-Merlin Signaling Dysregulation, Mitotic G2-G2/M phases, Nuclear events stimulated by ALK signaling in cancer, Polo-like kinase mediated events, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
UniProt: Q08050
Entrez ID: 2305
|
Does Knockout of ALKBH3 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
ALKBH3
|
cell proliferation
|
Bladder Carcinoma
|
Gene: ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase)
Type: protein-coding
Summary: The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: DNA alkylation repair, DNA damage response, DNA repair, cell population proliferation, negative regulation of cytoplasmic translation; MF: L-ascorbic acid binding, broad specificity oxidative DNA demethylase activity, dioxygenase activity, ferrous iron binding, mRNA N1-methyladenosine dioxygenase activity, metal ion binding, oxidative RNA demethylase activity, oxidoreductase activity, protein binding; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Direct Reversal Repair
UniProt: Q96Q83
Entrez ID: 221120
|
Does Knockout of TAF1L in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
TAF1L
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: TAF1L (TATA-box binding protein associated factor 1 like)
Type: protein-coding
Summary: This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript from the multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and the product has been shown to function interchangeably with the TAF1 product. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: DNA-templated transcription initiation, RNA polymerase II preinitiation complex assembly, chromatin organization, chromatin remodeling, male meiotic nuclear division, positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, TBP-class protein binding, histone acetyltransferase activity, histone reader activity, protein serine/threonine kinase activity; CC: nucleoplasm, nucleus, transcription factor TFIID complex
Pathways: Basal transcription factors - Homo sapiens (human), Disease, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcription of the HIV genome, Transcriptional Regulation by TP53, Viral Infection Pathways
UniProt: Q8IZX4
Entrez ID: 138474
|
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