prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of BTBD7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | BTBD7 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: BTBD7 (BTB domain containing 7)
Type: protein-coding
Summary: Predicted to be involved in regulation of branching involved in salivary gland morphogenesis. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: morphogenesis of a branch... |
Does Knockout of TP53BP2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | TP53BP2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: TP53BP2 (tumor protein p53 binding protein 2)
Type: protein-coding
Summary: This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is ... |
Does Knockout of BCL9L in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | BCL9L | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: BCL9L (BCL9 like)
Type: protein-coding
Summary: Enables beta-catenin binding activity. Involved in several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; and positive regulation of... |
Does Knockout of NUP43 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | NUP43 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: NUP43 (nucleoporin 43)
Type: protein-coding
Summary: Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (L... |
Does Knockout of PES1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | PES1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: PES1 (pescadillo ribosomal biogenesis factor 1)
Type: protein-coding
Summary: This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critic... |
Does Knockout of MS4A15 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | MS4A15 | cell proliferation | Ovarian Cancer Cell Line | Gene: MS4A15 (membrane spanning 4-domains A15)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q8N5U1
Entrez ID: 219995 |
Does Knockout of PTCD3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | PTCD3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: PTCD3 (pentatricopeptide repeat domain 3)
Type: protein-coding
Summary: Enables rRNA binding activity and ribosomal small subunit binding activity. Involved in mitochondrial translation. Located in several cellular components, including cytosol; mitochondrion; and nucleoplasm. Implicated in combin... |
Does Knockout of CALML5 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | CALML5 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: CALML5 (calmodulin like 5)
Type: protein-coding
Summary: This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a confo... |
Does Knockout of INIP in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | INIP | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: INIP (INTS3 and NABP interacting protein)
Type: protein-coding
Summary: The protein encoded by this gene is a subunit of single-stranded DNA binding complexes that are important for maintaining genome stability. These complexes are involved in G2/M checkpoint control and homologous recombination r... |
Does Knockout of UCN2 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | UCN2 | response to chemicals | Melanoma Cell Line | Gene: UCN2 (urocortin 2)
Type: protein-coding
Summary: This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the br... |
Does Knockout of PNISR in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | PNISR | cell proliferation | Prostate Cancer Cell Line | Gene: PNISR (PNN interacting serine and arginine rich protein)
Type: protein-coding
Summary: Enables RNA binding activity. Located in cytosol; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, nuclear speck, nucleoplasm, nucleus... |
Does Knockout of RPL37 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | RPL37 | cell proliferation | Medulloblastoma Cell Line | Gene: RPL37 (ribosomal protein L37)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of ZNF771 in Cancer Cell Line causally result in cell proliferation? | 0 | 193 | Knockout | ZNF771 | cell proliferation | Cancer Cell Line | Gene: ZNF771 (zinc finger protein 771)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of ELP5 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | ELP5 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ELP5 (elongator acetyltransferase complex subunit 5)
Type: protein-coding
Summary: Predicted to contribute to tRNA binding activity. Predicted to be involved in positive regulation of cell migration and tRNA modification. Located in cytosol and nucleoplasm. Part of elongator holoenzyme complex. [p... |
Does Knockout of WDR77 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | WDR77 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: WDR77 (WD repeat domain 77)
Type: protein-coding
Summary: The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded pro... |
Does Knockout of UQCC3 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | UQCC3 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: UQCC3 (ubiquinol-cytochrome c reductase complex assembly factor 3)
Type: protein-coding
Summary: Complex III is a mitochondrial inner membrane protein complex that transfers electrons from ubiquinol to cytochrome c. This gene encodes a protein that functions in complex III assembly. Mutations in t... |
Does Knockout of PRLHR in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | PRLHR | response to virus | Lung Cancer Cell Line | Gene: PRLHR (prolactin releasing hormone receptor)
Type: protein-coding
Summary: PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]
Gene ... |
Does Knockout of KRT6A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | KRT6A | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: KRT6A (keratin 6A)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratif... |
Does Knockout of SNAPC3 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | SNAPC3 | cell proliferation | Melanoma Cell Line | Gene: SNAPC3 (small nuclear RNA activating complex polypeptide 3)
Type: protein-coding
Summary: Predicted to enable RNA polymerase III type 3 promoter sequence-specific DNA binding activity and bent DNA binding activity. Predicted to contribute to RNA polymerase II cis-regulatory region sequence-specifi... |
Does Knockout of SLC10A2 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | SLC10A2 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SLC10A2 (solute carrier family 10 member 2)
Type: protein-coding
Summary: This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metab... |
Does Knockout of U2AF1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | U2AF1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: U2AF1 (U2 small nuclear RNA auxiliary factor 1)
Type: protein-coding
Summary: This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene... |
Does Knockout of INTS4 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | INTS4 | cell proliferation | Monocytic Leukemia Cell Line | Gene: INTS4 (integrator complex subunit 4)
Type: protein-coding
Summary: INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U... |
Does Knockout of TRPM1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | TRPM1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: TRPM1 (transient receptor potential cation channel subfamily M member 1)
Type: protein-coding
Summary: This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is... |
Does Knockout of PHYHIP in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | PHYHIP | cell proliferation | Mammary Gland Tumor Cell Line | Gene: PHYHIP (phytanoyl-CoA 2-hydroxylase interacting protein)
Type: protein-coding
Summary: Enables protein tyrosine kinase binding activity. Involved in protein localization. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, protein... |
Does Knockout of FAU in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | FAU | cell proliferation | Multiple Myeloma Cell Line | Gene: FAU (FAU ubiquitin like and ribosomal protein S30 fusion)
Type: protein-coding
Summary: This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and... |
Does Knockout of RPLP1 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | RPLP1 | cell proliferation | Cancer Cell Line | Gene: RPLP1 (ribosomal protein lateral stalk subunit P1)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct prote... |
Does Knockout of RWDD4 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | RWDD4 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: RWDD4 (RWD domain containing 4)
Type: protein-coding
Summary: RWD domain containing 4
Gene Ontology:
Pathways:
UniProt: Q6NW29
Entrez ID: 201965 |
Does Knockout of POLR2K in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | POLR2K | cell proliferation | Colorectal Cancer Cell Line | Gene: POLR2K (RNA polymerase II, I and III subunit K)
Type: protein-coding
Summary: This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provide... |
Does Knockout of CSMD3 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | CSMD3 | cell proliferation | Astrocytoma Cell Line | Gene: CSMD3 (CUB and Sushi multiple domains 3)
Type: protein-coding
Summary: Predicted to be involved in regulation of dendrite development. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of dendrite development; CC... |
Does Knockout of NOP56 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | NOP56 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: NOP56 (NOP56 ribonucleoprotein)
Type: protein-coding
Summary: Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded b... |
Does Knockout of COPS6 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | COPS6 | cell proliferation | Cancer Cell Line | Gene: COPS6 (COP9 signalosome subunit 6)
Type: protein-coding
Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalo... |
Does Knockout of MTA2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | MTA2 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: MTA2 (metastasis associated 1 family member 2)
Type: protein-coding
Summary: This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly e... |
Does Knockout of PES1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | PES1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: PES1 (pescadillo ribosomal biogenesis factor 1)
Type: protein-coding
Summary: This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critic... |
Does Knockout of HOXD8 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | HOXD8 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: HOXD8 (homeobox D8)
Type: protein-coding
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene ... |
Does Knockout of SCYL1 in Lymphoma Cell Line causally result in cell proliferation? | 1 | 646 | Knockout | SCYL1 | cell proliferation | Lymphoma Cell Line | Gene: SCYL1 (SCY1 like pseudokinase 1)
Type: protein-coding
Summary: This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA seque... |
Does Knockout of ASCL4 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | ASCL4 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ASCL4 (achaete-scute family bHLH transcription factor 4)
Type: protein-coding
Summary: Basic helix-loop-helix transcription factors, such as ASCL4, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).... |
Does Knockout of ASIC5 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | ASIC5 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: ASIC5 (acid sensing ion channel subunit family member 5)
Type: protein-coding
Summary: This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive N... |
Does Knockout of FCGR3B in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | FCGR3B | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: FCGR3B (Fc gamma receptor IIIb)
Type: protein-coding
Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immun... |
Does Knockout of PRAF2 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | PRAF2 | cell proliferation | Gastric Cancer Cell Line | Gene: PRAF2 (PRA1 domain family member 2)
Type: protein-coding
Summary: Predicted to be involved in L-glutamate transmembrane transport. Predicted to be located in endosome membrane. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resou... |
Does Knockout of SRY in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | SRY | response to chemicals | Glioblastoma Cell Line | Gene: SRY (sex determining region Y)
Type: protein-coding
Summary: This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutati... |
Does Knockout of FAM219B in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 0 | 1,480 | Knockout | FAM219B | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: FAM219B (family with sequence similarity 219 member B)
Type: protein-coding
Summary: family with sequence similarity 219 member B
Gene Ontology:
Pathways:
UniProt: Q5XKK7
Entrez ID: 57184 |
Does Knockout of DAPK2 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | DAPK2 | response to chemicals | Melanoma Cell Line | Gene: DAPK2 (death associated protein kinase 2)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to ... |
Does Knockout of TFR2 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | TFR2 | cell proliferation | Astrocytoma Cell Line | Gene: TFR2 (transferrin receptor 2)
Type: protein-coding
Summary: This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte funct... |
Does Knockout of DYNLRB1 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | DYNLRB1 | cell proliferation | Prostate Cancer Cell Line | Gene: DYNLRB1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated i... |
Does Knockout of NUP88 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | NUP88 | cell proliferation | Glioblastoma Cell Line | Gene: NUP88 (nucleoporin 88)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the ma... |
Does Knockout of COX18 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | COX18 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: COX18 (cytochrome c oxidase assembly factor COX18)
Type: protein-coding
Summary: This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase a... |
Does Knockout of GRINA in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,032 | Knockout | GRINA | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1)
Type: protein-coding
Summary: Predicted to enable transmembrane transporter binding activity. Predicted to act upstream of or within endoplasmic reticulum calcium ion homeostasis and negative regulation of endoplasmic ret... |
Does Knockout of FAM3D in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | FAM3D | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: FAM3D (FAM3 metabolism regulating signaling molecule D)
Type: protein-coding
Summary: Involved in negative regulation of insulin secretion. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Predicted to be active in extracellular space. [provided by A... |
Does Knockout of DPH1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | DPH1 | cell proliferation | Endometrial Cancer Cell Line | Gene: DPH1 (diphthamide biosynthesis 1)
Type: protein-coding
Summary: The protein encoded by this gene is an enzyme involved in the biosynthesis of diphthamide, a modified histidine found only in elongation factor-2 (EEF2). Diphthamide residues in EEF2 are targeted for ADP-ribosylation by diphtheria tox... |
Does Knockout of FUT9 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | FUT9 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: FUT9 (fucosyltransferase 9)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This ... |
Does Knockout of RALYL in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | RALYL | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: RALYL (RALY RNA binding protein like)
Type: protein-coding
Summary: Enables identical protein binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, identical protein binding, nucleic acid binding, protein binding; CC... |
Does Knockout of MS4A5 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | MS4A5 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: MS4A5 (membrane spanning 4-domains A5)
Type: protein-coding
Summary: This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression pa... |
Does Knockout of CGB8 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | CGB8 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: CGB8 (chorionic gonadotropin subunit beta 8)
Type: protein-coding
Summary: This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique be... |
Does Inhibition of RPTOR in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,184 | Inhibition | RPTOR | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: RPTOR (regulatory associated protein of MTOR complex 1)
Type: protein-coding
Summary: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associ... |
Does Knockout of ST3GAL5 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | ST3GAL5 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5)
Type: protein-coding
Summary: Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhes... |
Does Knockout of MAP4K1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | MAP4K1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1)
Type: protein-coding
Summary: Enables ATP binding activity and MAP kinase kinase kinase kinase activity. Involved in several processes, including JNK cascade; cellular response to phorbol 13-acetate 12-myristate; and protein phosphor... |
Does Knockout of SLC35E3 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | SLC35E3 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: SLC35E3 (solute carrier family 35 member E3)
Type: protein-coding
Summary: Predicted to enable antiporter activity and nucleotide-sugar transmembrane transporter activity. Predicted to be involved in carbohydrate derivative transport; nucleobase-containing compound transport; and transmembrane tra... |
Does Knockout of MCOLN3 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | MCOLN3 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: MCOLN3 (mucolipin TRP cation channel 3)
Type: protein-coding
Summary: This gene encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset heari... |
Does Knockout of METTL6 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | METTL6 | cell proliferation | Medulloblastoma Cell Line | Gene: METTL6 (methyltransferase 6, tRNA N3-cytidine)
Type: protein-coding
Summary: Enables enzyme binding activity. Involved in tRNA methylation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: methylation, tRNA methylation, tRNA modification, tRNA processing; MF: enzyme... |
Does Knockout of KCNK10 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | KCNK10 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: KCNK10 (potassium two pore domain channel subfamily K member 10)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under ... |
Does Knockout of GUF1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 206 | Knockout | GUF1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: GUF1 (GTP binding elongation factor GUF1)
Type: protein-coding
Summary: This gene encodes a GTPase that triggers back-translocation of the elongating ribosome during mitochondrial protein synthesis. The protein contains a highly conserved C-terminal domain not found in other GTPases that facilitat... |
Does Knockout of MFSD6L in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | MFSD6L | cell proliferation | Endometrial Cancer Cell Line | Gene: MFSD6L (major facilitator superfamily domain containing 6 like)
Type: protein-coding
Summary: Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane
Pathways:
U... |
Does Knockout of LMNB1 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | LMNB1 | cell proliferation | Breast Cancer Cell Line | Gene: LMNB1 (lamin B1)
Type: protein-coding
Summary: This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript va... |
Does Knockout of CLSPN in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | CLSPN | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: CLSPN (claspin)
Type: protein-coding
Summary: The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a n... |
Does Knockout of SEMG1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | SEMG1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: SEMG1 (semenogelin 1)
Type: protein-coding
Summary: The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-s... |
Does Knockout of ADNP in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | ADNP | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: ADNP (activity dependent neuroprotector homeobox)
Type: protein-coding
Summary: Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactiv... |
Does Knockout of RBL1 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 1 | 1,480 | Knockout | RBL1 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: RBL1 (RB transcriptional corepressor like 1)
Type: protein-coding
Summary: The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle r... |
Does Knockout of KAT7 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | KAT7 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: KAT7 (lysine acetyltransferase 7)
Type: protein-coding
Summary: The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional a... |
Does Knockout of WDR33 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | WDR33 | cell proliferation | Monocytic Leukemia Cell Line | Gene: WDR33 (WD repeat domain 33)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or m... |
Does Knockout of SOD1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | SOD1 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: SOD1 (superoxide dismutase 1)
Type: protein-coding
Summary: The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert... |
Does Knockout of C11orf52 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | C11orf52 | cell proliferation | Cancer Cell Line | Gene: C11orf52 (chromosome 11 open reading frame 52)
Type: protein-coding
Summary: Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: EGFR1
UniProt: Q96A22
Entrez ID: 91894 |
Does Knockout of MAGEA10 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | MAGEA10 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: MAGEA10 (MAGE family member A10)
Type: protein-coding
Summary: This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that ... |
Does Knockout of HELB in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | HELB | response to virus | Hepatoma Cell Line | Gene: HELB (DNA helicase B)
Type: protein-coding
Summary: This gene encodes a DNA-dependent ATPase which catalyzes the unwinding of DNA necessary for DNA replication, repair, recombination, and transcription. This gene is thought to function specifically during the S phase entry of the cell cycle. Alter... |
Does Knockout of AK2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | AK2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: AK2 (adenylate kinase 2)
Type: protein-coding
Summary: Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have bee... |
Does Knockout of SEPHS1 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | SEPHS1 | cell proliferation | Cancer Cell Line | Gene: SEPHS1 (selenophosphate synthetase 1)
Type: protein-coding
Summary: This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame ... |
Does Knockout of SCN2A in Prostate Cancer Cell Line causally result in response to chemicals? | 1 | 2,109 | Knockout | SCN2A | response to chemicals | Prostate Cancer Cell Line | Gene: SCN2A (sodium voltage-gated channel alpha subunit 2)
Type: protein-coding
Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulat... |
Does Knockout of PSMA1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | PSMA1 | cell proliferation | Gastric Cancer Cell Line | Gene: PSMA1 (proteasome 20S subunit alpha 1)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 ri... |
Does Knockout of AHCY in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | AHCY | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: AHCY (adenosylhomocysteinase)
Type: protein-coding
Summary: S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-a... |
Does Knockout of RHOT2 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | RHOT2 | cell proliferation | Ovarian Cancer Cell Line | Gene: RHOT2 (ras homolog family member T2)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]... |
Does Knockout of PRAMEF5 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | PRAMEF5 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PRAMEF5 (PRAME family member 5)
Type: protein-coding
Summary: Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; and positive regulation of cell population proliferation. Predicted to be active in ... |
Does Knockout of OR5D16 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | OR5D16 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: OR5D16 (olfactory receptor family 5 subfamily D member 16)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of KIF2A in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | KIF2A | cell proliferation | Colonic Cancer Cell Line | Gene: KIF2A (kinesin family member 2A)
Type: protein-coding
Summary: The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several tr... |
Does Knockout of PHF5A in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | PHF5A | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: PHF5A (PHD finger protein 5A)
Type: protein-coding
Summary: This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a co... |
Does Knockout of EMC1 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | EMC1 | cell proliferation | Cancer Cell Line | Gene: EMC1 (ER membrane protein complex subunit 1)
Type: protein-coding
Summary: This gene encodes a single-pass type I transmembrane protein, which is a subunit of the endoplasmic reticulum membrane protein complex (EMC). Multiple alternatively spliced transcript variants encoding different isoforms ha... |
Does Knockout of OR51A7 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | OR51A7 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: OR51A7 (olfactory receptor family 51 subfamily A member 7)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of TRIM11 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | TRIM11 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: TRIM11 (tripartite motif containing 11)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes ... |
Does Knockout of HNRNPUL2 in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | HNRNPUL2 | response to virus | Lung Cancer Cell Line | Gene: HNRNPUL2 (heterogeneous nuclear ribonucleoprotein U like 2)
Type: protein-coding
Summary: Enables RNA binding activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding; CC: membrane, nucleoplasm, nucleus, synapse
Pathway... |
Does Knockout of CDC27 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | CDC27 | cell proliferation | Melanoma Cell Line | Gene: CDC27 (cell division cycle 27)
Type: protein-coding
Summary: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is... |
Does Knockout of P2RX6 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | P2RX6 | cell proliferation | Colonic Cancer Cell Line | Gene: P2RX6 (purinergic receptor P2X 6)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated ... |
Does Knockout of DHX33 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | DHX33 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: DHX33 (DEAH-box helicase 33)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving a... |
Does Knockout of PPA2 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | PPA2 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: PPA2 (inorganic pyrophosphatase 2)
Type: protein-coding
Summary: The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPas... |
Does Knockout of RAD51 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | RAD51 | cell proliferation | Colonic Cancer Cell Line | Gene: RAD51 (RAD51 recombinase)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of... |
Does Knockout of HEPH in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | HEPH | cell proliferation | Endometrial Cancer Cell Line | Gene: HEPH (hephaestin)
Type: protein-coding
Summary: This gene encodes a member of the multicopper oxidase protein family. The encoded protein is involved in the transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system, and may be involved in copper transport ... |
Does Knockout of PRSS48 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | PRSS48 | cell proliferation | Melanoma Cell Line | Gene: PRSS48 (serine protease 48)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: proteolysis; MF... |
Does Knockout of FAM234A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | FAM234A | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: FAM234A (family with sequence similarity 234 member A)
Type: protein-coding
Summary: Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cell surface, extracellular exosome, membrane
Pathways:
UniProt: Q9H0X4
Entrez I... |
Does Knockout of HOXB5 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | HOXB5 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: HOXB5 (homeobox B5)
Type: protein-coding
Summary: This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific trans... |
Does Knockout of SNRNP25 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | SNRNP25 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SNRNP25 (small nuclear ribonucleoprotein U11/U12 subunit 25)
Type: protein-coding
Summary: Two types of spliceosomes catalyze splicing of pre-mRNAs. The major U2-type spliceosome is found in all eukaryotes and removes U2-type introns, which represent more than 99% of pre-mRNA introns. The minor U1... |
Does Knockout of FOXM1 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | FOXM1 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: FOXM1 (forkhead box M1)
Type: protein-coding
Summary: The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several ... |
Does Knockout of ALKBH3 in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | ALKBH3 | cell proliferation | Bladder Carcinoma | Gene: ALKBH3 (alkB homolog 3, alpha-ketoglutarate dependent dioxygenase)
Type: protein-coding
Summary: The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. c... |
Does Knockout of TAF1L in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | TAF1L | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: TAF1L (TATA-box binding protein associated factor 1 like)
Type: protein-coding
Summary: This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript from the multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and ... |
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