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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of LETM1 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
LETM1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: LETM1 (leucine zipper and EF-hand containing transmembrane protein 1)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: calcium export from the mitochondrion, calcium ion transport, cristae formation, inner mitochondrial membrane organization, mitochondrial calcium ion homeostasis, mitochondrial calcium ion transmembrane transport, mitochondrial potassium ion transmembrane transport, mitochondrion organization, monoatomic ion transport, negative regulation of mitochondrial calcium ion concentration, potassium ion transport, protein hexamerization, protein homooligomerization, proton transmembrane transport, regulation of cellular hyperosmotic salinity response; MF: antiporter activity, calcium ion binding, calcium:proton antiporter activity, metal ion binding, protein binding, ribosome binding; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex III assembly, Metabolism, Mitochondrial calcium ion transport, RHO GTPase cycle, RHOG GTPase cycle, Respiratory electron transport, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport of small molecules
UniProt: O95202
Entrez ID: 3954
|
Does Knockout of ASGR2 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
ASGR2
|
response to virus
|
Lung Cancer Cell Line
|
Gene: ASGR2 (asialoglycoprotein receptor 2)
Type: protein-coding
Summary: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: cell surface receptor signaling pathway, endocytosis, immune response; MF: D-mannose binding, asialoglycoprotein receptor activity, carbohydrate binding, fucose binding, pattern recognition receptor activity, protein binding; CC: endoplasmic reticulum quality control compartment, external side of plasma membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Thyroid hormone synthesis - Homo sapiens (human)
UniProt: P07307
Entrez ID: 433
|
Does Knockout of RBM19 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
RBM19
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: RBM19 (RNA binding motif protein 19)
Type: protein-coding
Summary: This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Apr 2009].
Gene Ontology: BP: positive regulation of embryonic development, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding; CC: chromosome, cytoplasm, membrane, nuclear speck, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9Y4C8
Entrez ID: 9904
|
Does Knockout of ANXA8L1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
ANXA8L1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ANXA8L1 (annexin A8 like 1)
Type: protein-coding
Summary: This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: endosomal transport, endosome organization; MF: calcium ion binding, calcium-dependent phospholipid binding, metal ion binding, phosphatidylserine binding; CC: cytoplasm, sarcolemma, vesicle membrane
Pathways:
UniProt: Q5VT79, P13928
Entrez ID: 728113
|
Does Knockout of OSTF1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
OSTF1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: OSTF1 (osteoclast stimulating factor 1)
Type: protein-coding
Summary: Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: ossification, signal transduction; MF: SH3 domain binding, protein binding; CC: cytoplasm, extracellular region, ficolin-1-rich granule lumen, secretory granule lumen
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q92882
Entrez ID: 26578
|
Does Knockout of TACR3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
TACR3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TACR3 (tachykinin receptor 3)
Type: protein-coding
Summary: This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, positive regulation of blood pressure, positive regulation of flagellated sperm motility, positive regulation of heart rate, positive regulation of uterine smooth muscle contraction, regulation of dopamine metabolic process, regulation of feeding behavior, response to cocaine, response to estradiol, signal transduction, tachykinin receptor signaling pathway; MF: G protein-coupled receptor activity, protein binding, tachykinin receptor activity; CC: dendrite membrane, membrane, neuronal cell body membrane, plasma membrane, sperm midpiece
Pathways: Calcium signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide GPCRs, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Tachykinin receptors bind tachykinins
UniProt: P29371
Entrez ID: 6870
|
Does Knockout of MAST1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
MAST1
|
cell proliferation
|
Cancer Cell Line
|
Gene: MAST1 (microtubule associated serine/threonine kinase 1)
Type: protein-coding
Summary: This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017].
Gene Ontology: BP: brain development, cytoskeleton organization, developmental process, intracellular signal transduction, protein phosphorylation; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, microtubule binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: axon, cell projection, cytoplasm, cytoskeleton, dendrite, membrane, microtubule cytoskeleton, neuron projection, neuronal cell body, plasma membrane
Pathways:
UniProt: Q9Y2H9
Entrez ID: 22983
|
Does Knockout of SYT12 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
SYT12
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: SYT12 (synaptotagmin 12)
Type: protein-coding
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010].
Gene Ontology: BP: long-term synaptic potentiation, presynaptic modulation of chemical synaptic transmission, regulation of calcium ion-dependent exocytosis, spontaneous exocytosis of neurotransmitter, vesicle-mediated transport; MF: SNARE binding, calcium ion sensor activity, calcium-dependent phospholipid binding; CC: cytoplasmic vesicle, exocytic vesicle, hippocampal mossy fiber to CA3 synapse, membrane, plasma membrane, presynapse, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways: Neurexins and neuroligins, Neuronal System, Protein-protein interactions at synapses
UniProt: Q8IV01
Entrez ID: 91683
|
Does Knockout of TNNC1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
TNNC1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TNNC1 (troponin C1, slow skeletal and cardiac type)
Type: protein-coding
Summary: Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: cardiac muscle cell contraction, cardiac muscle contraction, diaphragm contraction, muscle filament sliding, regulation of muscle contraction, regulation of muscle filament sliding speed, response to metal ion, skeletal muscle contraction, transition between fast and slow fiber, ventricular cardiac muscle tissue morphogenesis; MF: actin filament binding, calcium ion binding, calcium-dependent protein binding, cytoskeletal protein binding, metal ion binding, protein binding, protein homodimerization activity, troponin I binding, troponin T binding; CC: cardiac Troponin complex, contractile muscle fiber, cytosol, sarcomere, troponin complex
Pathways: Acebutolol Action Pathway, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alprenolol Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupranolol Action Pathway, Calcium signaling pathway - Homo sapiens (human), Cardiac muscle contraction - Homo sapiens (human), Carteolol Action Pathway, Carvedilol Action Pathway, Dilated cardiomyopathy - Homo sapiens (human), Diltiazem Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Epinephrine Action Pathway, Esmolol Action Pathway, Felodipine Action Pathway, Flecainide Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, Hypertrophic cardiomyopathy - Homo sapiens (human), Ibutilide Action Pathway, Isoprenaline Action Pathway, Isradipine Action Pathway, Labetalol Action Pathway, Levobunolol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, MFAP5-mediated ovarian cancer cell motility and invasiveness, Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Muscle contraction, Muscle/Heart Contraction, Nadolol Action Pathway, Nebivolol Action Pathway, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Penbutolol Action Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Practolol Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Sotalol Action Pathway, Striated Muscle Contraction, Striated Muscle Contraction Pathway, Timolol Action Pathway, Tocainide Action Pathway, Verapamil Action Pathway
UniProt: P63316
Entrez ID: 7134
|
Does Knockout of SMC4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
SMC4
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: SMC4 (structural maintenance of chromosomes 4)
Type: protein-coding
Summary: This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome condensation and sister chromatid cohesion. The protein encoded by this gene is likely a subunit of the 13S condensin complex, which is involved in chromosome condensation. A pseudogene related to this gene is located on chromosome 2. [provided by RefSeq, Jun 2016].
Gene Ontology: BP: cell division, chromosome condensation, chromosome organization, kinetochore organization, meiotic chromosome condensation, meiotic chromosome segregation, mitotic chromosome condensation, mitotic sister chromatid segregation, nuclear chromosome segregation, nuclear division, positive regulation of chromosome condensation, positive regulation of chromosome segregation, positive regulation of chromosome separation; MF: ATP binding, ATP hydrolysis activity, chromatin binding, nucleotide binding, protein binding, single-stranded DNA binding; CC: chromosome, chromosome, centromeric region, condensed nuclear chromosome, condensin complex, cytoplasm, cytosol, nuclear lumen, nuclear speck, nucleoplasm, nucleus
Pathways: Aurora B signaling, Cell Cycle, Cell Cycle, Mitotic, Ciliary landscape, Condensation of Prometaphase Chromosomes, Condensation of Prophase Chromosomes, M Phase, Mitotic Prometaphase, Mitotic Prophase
UniProt: Q9NTJ3
Entrez ID: 10051
|
Does Knockout of RPS25 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
RPS25
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RPS25 (ribosomal protein S25)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S25E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, rRNA processing, ribosomal small subunit biogenesis, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, nucleolus, nucleoplasm, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62851
Entrez ID: 6230
|
Does Knockout of PDCD4 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
PDCD4
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: PDCD4 (programmed cell death 4)
Type: protein-coding
Summary: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: BMP signaling pathway, apoptotic process, cellular response to lipopolysaccharide, epithelial to mesenchymal transition involved in cardiac fibroblast development, negative regulation of DNA-templated transcription, negative regulation of JUN kinase activity, negative regulation of cytokine production involved in inflammatory response, negative regulation of myofibroblast differentiation, negative regulation of vascular associated smooth muscle cell differentiation, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of endothelial cell apoptotic process, positive regulation of inflammatory response, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of vascular associated smooth muscle cell apoptotic process; MF: RNA binding, protein binding; CC: cytoplasm, cytosol, nucleus
Pathways: Cytokine Signaling in Immune system, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Immune System, Interferon type I signaling pathways, Interleukin-12 family signaling, Interleukin-12 signaling, MicroRNAs in cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Signaling by Interleukins, Translation inhibitors in chronically activated PDGFRA cells, mTOR signaling pathway
UniProt: Q53EL6
Entrez ID: 27250
|
Does Knockout of TUBE1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
TUBE1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: TUBE1 (tubulin epsilon 1)
Type: protein-coding
Summary: This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009].
Gene Ontology: BP: centrosome cycle, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, nucleotide binding, structural constituent of cytoskeleton; CC: centrosome, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, pericentriolar material
Pathways: Genes related to primary cilium development (based on CRISPR)
UniProt: Q9UJT0
Entrez ID: 51175
|
Does Knockout of PPP1R8 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
PPP1R8
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: PPP1R8 (protein phosphatase 1 regulatory subunit 8)
Type: protein-coding
Summary: This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA catabolic process, RNA splicing, cell population proliferation, mRNA processing; MF: DNA binding, RNA binding, RNA endonuclease activity, endonuclease activity, hydrolase activity, mRNA binding, molecular function inhibitor activity, nuclease activity, protein binding, protein phosphatase inhibitor activity, protein phosphatase regulator activity, protein serine/threonine phosphatase inhibitor activity, ribonuclease E activity; CC: cytoplasm, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways:
UniProt: Q12972
Entrez ID: 5511
|
Does Knockout of WDR7 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
WDR7
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: WDR7 (WD repeat domain 7)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein forms the beta subunit of rabconnectin-3 and binds directly with Rab3A GDP/GTP exchange protein and indirectly with Rab3A GDP/GTP activating protein; these proteins are regulators of Rab3 small G protein family members involved in control of the calcium-dependant exocytosis of neurotransmitters. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways:
UniProt: Q9Y4E6
Entrez ID: 23335
|
Does Knockout of SRP68 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
SRP68
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: SRP68 (signal recognition particle 68)
Type: protein-coding
Summary: This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012].
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, response to xenobiotic stimulus; MF: 7S RNA binding, RNA binding, endoplasmic reticulum signal peptide binding, protein binding, protein domain specific binding, ribosome binding, signal recognition particle binding; CC: cytoplasm, cytosol, endoplasmic reticulum, focal adhesion, nucleolus, nucleus, ribonucleoprotein complex, ribosome, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Homo sapiens (human), SRP-dependent cotranslational protein targeting to membrane, Translation
UniProt: Q9UHB9
Entrez ID: 6730
|
Does Knockout of CDC26 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
CDC26
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CDC26 (cell division cycle 26)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; CC: anaphase-promoting complex, cytosol, nucleoplasm, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q8NHZ8
Entrez ID: 246184
|
Does Knockout of ZNF442 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
ZNF442
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ZNF442 (zinc finger protein 442)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9H7R0
Entrez ID: 79973
|
Does Knockout of SGCZ in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
SGCZ
|
cell proliferation
|
Cancer Cell Line
|
Gene: SGCZ (sarcoglycan zeta)
Type: protein-coding
Summary: The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cardiac muscle tissue development, heart contraction, membrane organization, muscle cell cellular homeostasis, muscle cell development; CC: Golgi membrane, cytoplasm, cytoskeleton, endoplasmic reticulum membrane, membrane, plasma membrane, sarcoglycan complex, sarcolemma
Pathways: Extracellular matrix organization, Formation of the dystrophin-glycoprotein complex (DGC), Non-integrin membrane-ECM interactions
UniProt: Q96LD1
Entrez ID: 137868
|
Does Knockout of EPS15L1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
EPS15L1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1)
Type: protein-coding
Summary: Enables cadherin binding activity. Predicted to be involved in endocytosis and endosomal transport. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endocytosis, endosomal transport, synaptic vesicle endocytosis; MF: cadherin binding, calcium ion binding, metal ion binding, protein binding, protein-macromolecule adaptor activity; CC: clathrin coat of coated pit, clathrin-coated pit, cytoplasm, cytosol, membrane, nucleus, plasma membrane, presynapse
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, EGF-EGFR signaling pathway, EGFR downregulation, Endocytosis - Homo sapiens (human), Membrane Trafficking, Signal Transduction, Signaling by EGFR, Signaling by Receptor Tyrosine Kinases, Vesicle-mediated transport
UniProt: Q9UBC2
Entrez ID: 58513
|
Does Knockout of TTC33 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
TTC33
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: TTC33 (tetratricopeptide repeat domain 33)
Type: protein-coding
Summary: tetratricopeptide repeat domain 33
Gene Ontology:
Pathways:
UniProt: Q6PID6
Entrez ID: 23548
|
Does Activation of APOBEC3C in T cell causally result in protein/peptide accumulation?
| 1
| 2,426
|
Activation
|
APOBEC3C
|
protein/peptide accumulation
|
T cell
|
Gene: APOBEC3C (apolipoprotein B mRNA editing enzyme catalytic subunit 3C)
Type: protein-coding
Summary: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA cytosine deamination, clearance of foreign intracellular DNA, cytidine to uridine editing, defense response to symbiont, defense response to virus, immune system process, innate immune response, negative regulation of macromolecule biosynthetic process, negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, negative regulation of viral genome replication, positive regulation of gene expression via chromosomal CpG island demethylation, transposable element silencing; MF: RNA binding, catalytic activity, cytidine deaminase activity, hydrolase activity, metal ion binding, protein binding, zinc ion binding; CC: P-body, cytoplasm, nucleus
Pathways: Formation of the Editosome, Human immunodeficiency virus 1 infection - Homo sapiens (human), Metabolism of RNA, mRNA Editing, mRNA Editing: C to U Conversion
UniProt: Q9NRW3
Entrez ID: 27350
|
Does Knockout of EEF2KMT in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
EEF2KMT
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase)
Type: protein-coding
Summary: Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: methylation, peptidyl-lysine trimethylation; MF: methyltransferase activity, protein binding, protein-lysine N-methyltransferase activity, transferase activity; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Protein methylation
UniProt: Q96G04
Entrez ID: 196483
|
Does Knockout of KPNB1 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
KPNB1
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: KPNB1 (karyopherin subunit beta 1)
Type: protein-coding
Summary: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].
Gene Ontology: BP: NLS-bearing protein import into nucleus, RNA import into nucleus, astral microtubule organization, establishment of mitotic spindle localization, intracellular protein transport, mitotic chromosome movement towards spindle pole, mitotic metaphase chromosome alignment, mitotic spindle assembly, positive regulation of DNA-templated transcription, positive regulation of cholesterol biosynthetic process, positive regulation of hippo signaling, protein import into nucleus, protein transport, ribosomal protein import into nucleus; MF: Hsp90 protein binding, RNA binding, enzyme binding, importin-alpha family protein binding, nuclear import signal receptor activity, nuclear localization sequence binding, protein binding, protein domain specific binding, small GTPase binding, zinc ion binding; CC: NLS-dependent protein nuclear import complex, cytoplasm, cytoplasmic stress granule, cytosol, endoplasmic reticulum tubular network, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, membrane, nuclear envelope, nuclear membrane, nuclear pore, nucleoplasm, nucleus, protein-containing complex, specific granule lumen
Pathways: 22q11.2 copy number variation syndrome, RNA transport - Homo sapiens (human), Regulation of cytoplasmic and nuclear SMAD2/3 signaling, Role of Calcineurin-dependent NFAT signaling in lymphocytes, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by TCPTP, Sterol regulatory element-binding proteins (SREBP) signaling, TGF_beta_Receptor, mechanism of protein import into the nucleus, role of ran in mitotic spindle regulation
UniProt: Q14974
Entrez ID: 3837
|
Does Knockout of SAP30BP in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
SAP30BP
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: SAP30BP (SAP30 binding protein)
Type: protein-coding
Summary: Involved in modulation by host of symbiont transcription; positive regulation of histone deacetylation; and response to virus. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, response to virus; CC: intermediate filament cytoskeleton, nucleoplasm, nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression
UniProt: Q9UHR5
Entrez ID: 29115
|
Does Knockout of ARL4D in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
ARL4D
|
cell proliferation
|
Cancer Cell Line
|
Gene: ARL4D (ARF like GTPase 4D)
Type: protein-coding
Summary: ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. [provided by RefSeq, Jul 2021].
Gene Ontology: BP: intracellular protein transport, protein secretion, vesicle-mediated transport; MF: GTP binding, GTPase activity, nucleotide binding, protein binding; CC: cytoplasm, membrane, nucleolus, nucleus, plasma membrane
Pathways: IL-18 signaling pathway
UniProt: P49703
Entrez ID: 379
|
Does Knockout of RPS4X in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
RPS4X
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: RPS4X (ribosomal protein S4 X-linked)
Type: protein-coding
Summary: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, positive regulation of cell population proliferation, positive regulation of translation, ribosomal small subunit biogenesis, translation; MF: RNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62701
Entrez ID: 6191
|
Does Knockout of SSX2IP in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
SSX2IP
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: SSX2IP (SSX family member 2 interacting protein)
Type: protein-coding
Summary: This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: cell adhesion, cell projection organization, centrosome cycle, cilium assembly, intraciliary transport involved in cilium assembly, regulation of Rac protein signal transduction, regulation of cell motility; MF: protein binding, protein domain specific binding; CC: adherens junction, anchoring junction, cell leading edge, cell projection, centriolar satellite, centrosome, ciliary basal body, cytoplasm, cytoskeleton, nucleus, protein-containing complex
Pathways: Adherens junction - Homo sapiens (human)
UniProt: Q9Y2D8
Entrez ID: 117178
|
Does Knockout of TAX1BP3 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
TAX1BP3
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TAX1BP3 (Tax1 binding protein 3)
Type: protein-coding
Summary: This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017].
Gene Ontology: BP: Rho protein signal transduction, Wnt signaling pathway, negative regulation of Wnt signaling pathway, negative regulation of cell population proliferation, negative regulation of protein localization to cell surface, regulation of Cdc42 protein signal transduction; MF: beta-catenin binding, protein binding; CC: actin cytoskeleton, cytoplasm, cytosol, extracellular exosome, fibrillar center, membrane, nucleus, plasma membrane
Pathways: RHO GTPase Effectors, RHO GTPases Activate Rhotekin and Rhophilins, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O14907
Entrez ID: 30851
|
Does Knockout of YEATS2 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
YEATS2
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: YEATS2 (YEATS domain containing 2)
Type: protein-coding
Summary: Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017].
Gene Ontology: BP: chromatin remodeling, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II; MF: TBP-class protein binding, histone binding, histone reader activity, modification-dependent protein binding, protein binding, transcription corepressor activity; CC: ATAC complex, NuA4 histone acetyltransferase complex, mitotic spindle, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones
UniProt: Q9ULM3
Entrez ID: 55689
|
Does Knockout of GART in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
GART
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase)
Type: protein-coding
Summary: The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 'de novo' AMP biosynthetic process, 'de novo' IMP biosynthetic process, 'de novo' XMP biosynthetic process, GMP biosynthetic process, adenine biosynthetic process, brainstem development, cerebellum development, cerebral cortex development, purine nucleobase biosynthetic process, purine nucleotide biosynthetic process, purine ribonucleoside monophosphate biosynthetic process; MF: ATP binding, catalytic activity, ligase activity, ligase activity, forming carbon-nitrogen bonds, metal ion binding, nucleotide binding, phosphoribosylamine-glycine ligase activity, phosphoribosylformylglycinamidine cyclo-ligase activity, phosphoribosylglycinamide formyltransferase activity, transferase activity; CC: cytosol, extracellular exosome
Pathways: 5-aminoimidazole ribonucleotide biosynthesis, AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Folate Metabolism, Gout or Kelley-Seegmiller Syndrome, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide biosynthesis, One carbon pool by folate - Homo sapiens (human), One-carbon metabolism, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Purine ribonucleoside monophosphate biosynthesis, Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, purine nucleotides <i>de novo</i> biosynthesis, tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate
UniProt: P22102
Entrez ID: 2618
|
Does Knockout of ESPL1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
ESPL1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: ESPL1 (extra spindle pole bodies like 1, separase)
Type: protein-coding
Summary: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: apoptotic process, chromosome segregation, establishment of mitotic spindle localization, homologous chromosome segregation, meiosis I, meiotic chromosome separation, meiotic spindle organization, mitotic cell cycle, mitotic cytokinesis, mitotic sister chromatid segregation, mitotic sister chromatid separation, negative regulation of sister chromatid cohesion, nuclear chromosome segregation, nuclear division, positive regulation of mitotic metaphase/anaphase transition, proteolysis; MF: catalytic activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding; CC: centrosome, cytoplasm, cytosol, mitotic spindle, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Oocyte meiosis - Homo sapiens (human), Regulation of sister chromatid separation at the metaphase-anaphase transition, Separation of Sister Chromatids
UniProt: Q14674
Entrez ID: 9700
|
Does Knockout of AFTPH in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
AFTPH
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: AFTPH (aftiphilin)
Type: protein-coding
Summary: Enables clathrin binding activity. Predicted to be involved in intracellular transport. Located in Golgi apparatus; cytosol; and nucleoplasm. Part of AP-1 adaptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intracellular transport, protein transport; MF: clathrin binding, protein binding; CC: AP-1 adaptor complex, Golgi apparatus, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, nucleoplasm, perinuclear region of cytoplasm, trans-Golgi network membrane
Pathways:
UniProt: Q6ULP2
Entrez ID: 54812
|
Does Knockout of CHMP7 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
CHMP7
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: CHMP7 (charged multivesicular body protein 7)
Type: protein-coding
Summary: Involved in several processes, including late endosome to vacuole transport; midbody abscission; and mitotic nuclear division. Located in cytosol; nuclear envelope; and nucleoplasm. Part of ESCRT III complex. Colocalizes with chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ESCRT III complex disassembly, autophagosome maturation, autophagy, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport, late endosome to vacuole transport via multivesicular body sorting pathway, membrane fission, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein localization to chromatin, protein transport, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, chromatin, cytoplasm, cytoplasmic side of plasma membrane, cytosol, kinetochore, kinetochore microtubule, lysosomal membrane, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleoplasm, nucleus, plasma membrane
Pathways: Autophagy, Budding and maturation of HIV virion, Cell Cycle, Cell Cycle, Mitotic, Disease, Early SARS-CoV-2 Infection Events, Endocytosis - Homo sapiens (human), Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Infectious disease, Late Phase of HIV Life Cycle, Late endosomal microautophagy, M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Homo sapiens (human), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Sealing of the nuclear envelope (NE) by ESCRT-III, Translation of Replicase and Assembly of the Replication Transcription Complex, Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q8WUX9
Entrez ID: 91782
|
Does Knockout of TICRR in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
TICRR
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: TICRR (TOPBP1 interacting checkpoint and replication regulator)
Type: protein-coding
Summary: Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, regulation of DNA-templated DNA replication initiation, response to ionizing radiation; MF: chromatin binding, protein binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Transition, Mitotic G2-G2/M phases
UniProt: Q7Z2Z1
Entrez ID: 90381
|
Does Knockout of NSRP1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
NSRP1
|
response to virus
|
Hepatoma Cell Line
|
Gene: NSRP1 (nuclear speckle splicing regulatory protein 1)
Type: protein-coding
Summary: Enables mRNA binding activity. Involved in developmental process and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, developmental process, in utero embryonic development, mRNA processing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, protein binding; CC: nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9H0G5
Entrez ID: 84081
|
Does Knockout of RPAIN in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
RPAIN
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RPAIN (RPA interacting protein)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including DNA metabolic process; protein import into nucleus; and response to UV. Located in PML body; cytoplasm; and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein import into nucleus, response to UV; MF: metal ion binding, protein binding, zinc ion binding; CC: PML body, cytoplasm, fibrillar center, nucleoplasm, nucleus
Pathways:
UniProt: Q86UA6
Entrez ID: 84268
|
Does Knockout of NDUFA3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
NDUFA3
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: NDUFA3 (NADH:ubiquinone oxidoreductase subunit A3)
Type: protein-coding
Summary: Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: aerobic respiration, mitochondrial electron transport, NADH to ubiquinone, proton motive force-driven mitochondrial ATP synthesis, proton transmembrane transport; MF: NADH dehydrogenase (ubiquinone) activity, protein binding; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Huntington disease - Homo sapiens (human), Metabolism, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human)
UniProt: O95167
Entrez ID: 4696
|
Does Knockout of DYNC1H1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
DYNC1H1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Type: protein-coding
Summary: Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: P-body assembly, cell division, cytoplasmic microtubule organization, establishment of spindle localization, microtubule-based movement, mitotic spindle organization, nuclear migration, positive regulation of cold-induced thermogenesis, positive regulation of intracellular transport, positive regulation of spindle assembly, regulation of metaphase plate congression, regulation of mitotic spindle organization, retrograde axonal transport, stress granule assembly; MF: ATP binding, RNA binding, dynein intermediate chain binding, dynein light intermediate chain binding, identical protein binding, minus-end-directed microtubule motor activity, nucleotide binding, protein binding; CC: axon cytoplasm, azurophil granule lumen, cell cortex, centrosome, cytoplasm, cytoplasmic dynein complex, cytoplasmic microtubule, cytoskeleton, cytosol, dynein complex, extracellular exosome, extracellular region, filopodium, membrane, microtubule
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Aggrephagy, Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, Autophagy, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Ciliary landscape, Cilium Assembly, Disease, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HCMV Early Events, HCMV Infection, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Immune System, Infectious disease, Innate Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport proteins binding to dynein, Lissencephaly gene (LIS1) in neuronal migration and development, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Neutrophil degranulation, Organelle biogenesis and maintenance, Phagosome - Homo sapiens (human), Post-translational protein modification, RHO GTPase Effectors, RHO GTPases Activate Formins, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, Salmonella infection - Homo sapiens (human), Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q14204
Entrez ID: 1778
|
Does Knockout of CCDC43 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
CCDC43
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: CCDC43 (coiled-coil domain containing 43)
Type: protein-coding
Summary: Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q96MW1
Entrez ID: 124808
|
Does Knockout of CDC27 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
CDC27
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: CDC27 (cell division cycle 27)
Type: protein-coding
Summary: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, metaphase/anaphase transition of mitotic cell cycle, neuron projection development, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; MF: protein binding, protein phosphatase binding; CC: anaphase-promoting complex, centrosome, cytoplasm, cytoskeleton, cytosol, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: Cell cycle, Cell cycle - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), TGF_beta_Receptor, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: P30260
Entrez ID: 996
|
Does Knockout of INTS4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
INTS4
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: INTS4 (integrator complex subunit 4)
Type: protein-coding
Summary: INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, regulation of transcription elongation by RNA polymerase II, snRNA processing; MF: protein binding, protein-macromolecule adaptor activity; CC: INTAC complex, cytoplasm, integrator complex, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q96HW7
Entrez ID: 92105
|
Does Activation of L2HGDH in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
L2HGDH
|
protein/peptide accumulation
|
T cell
|
Gene: L2HGDH (L-2-hydroxyglutarate dehydrogenase)
Type: protein-coding
Summary: This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive neurometabolic disorder resulting in moderate to severe cognitive disability. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 2-oxoglutarate metabolic process, small molecule metabolic process; MF: 2-hydroxyglutarate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on CH-OH group of donors; CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Butanoate metabolism - Homo sapiens (human), Cerebral organic acidurias, including diseases, Interconversion of 2-oxoglutarate and 2-hydroxyglutarate, Metabolism, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria
UniProt: Q9H9P8
Entrez ID: 79944
|
Does Knockout of ANKLE2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
ANKLE2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ANKLE2 (ankyrin repeat and LEM domain containing 2)
Type: protein-coding
Summary: This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: cell division, central nervous system development, mitotic nuclear membrane reassembly, negative regulation of apoptotic process, negative regulation of phosphorylation, nervous system development, nuclear membrane reassembly, regulation of catalytic activity; MF: protein binding, protein kinase inhibitor activity, protein phosphatase 2A binding, protein phosphatase regulator activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Cell Cycle, Cell Cycle, Mitotic, Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Nuclear Envelope (NE) Reassembly, RAC2 GTPase cycle, RHO GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q86XL3
Entrez ID: 23141
|
Does Knockout of FLT3LG in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
FLT3LG
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: FLT3LG (fms related receptor tyrosine kinase 3 ligand)
Type: protein-coding
Summary: Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011].
Gene Ontology: BP: B cell differentiation, dendritic cell differentiation, embryonic hemopoiesis, positive regulation of cell population proliferation, positive regulation of natural killer cell proliferation, signal transduction; MF: cytokine activity, protein binding, receptor tyrosine kinase binding, signaling receptor binding; CC: cell surface, cytosol, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Constitutive Signaling by Aberrant PI3K in Cancer, Cytokine Signaling in Immune system, Development of pulmonary dendritic cells and macrophage subsets, Differentiation Pathway, Disease, Diseases of signal transduction by growth factor receptors and second messengers, FLT3 Signaling, FLT3 signaling by CBL mutants, FLT3 signaling in disease, FLT3 signaling through SRC family kinases, Hematopoietic cell lineage - Homo sapiens (human), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, Negative regulation of FLT3, Negative regulation of the PI3K/AKT network, PI3K Cascade, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Homo sapiens (human), RAF/MAP kinase cascade, Ras signaling pathway - Homo sapiens (human), STAT5 Activation, Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: P49771
Entrez ID: 2323
|
Does Knockout of CYP2W1 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
CYP2W1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: CYP2W1 (cytochrome P450 family 2 subfamily W member 1)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: aflatoxin metabolic process, cytochrome metabolic process, lipid metabolic process, organic acid metabolic process, phospholipid metabolic process, retinoic acid catabolic process, xenobiotic metabolic process; MF: all-trans retinal binding, all-trans-retinol binding, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, retinoic acid 4-hydroxylase activity, retinoic acid binding; CC: cell surface, cytoplasm, endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, plasma membrane
Pathways: Biological oxidations, Cytochrome P450 - arranged by substrate type, Metabolism, Metapathway biotransformation Phase I and II, Miscellaneous substrates, Oxidation by Cytochrome P450, Phase I - Functionalization of compounds, Retinol metabolism - Homo sapiens (human), Xenobiotics
UniProt: Q8TAV3
Entrez ID: 54905
|
Does Knockout of LFNG in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
LFNG
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)
Type: protein-coding
Summary: This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the MFNG (GeneID: 4242) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. [provided by RefSeq, May 2018].
Gene Ontology: BP: T cell differentiation, animal organ morphogenesis, compartment pattern specification, marginal zone B cell differentiation, negative regulation of Notch signaling pathway involved in somitogenesis, ovarian follicle development, pattern specification process, positive regulation of Notch signaling pathway, positive regulation of meiotic cell cycle, regulation of Notch signaling pathway, regulation of somitogenesis, somitogenesis; MF: O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity, glycosyltransferase activity, metal ion binding, transferase activity; CC: Golgi apparatus, Golgi membrane, extracellular region, extracellular vesicle, membrane
Pathways: Defective LFNG causes SCDO3, Developmental Biology, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Formation of paraxial mesoderm, Gastrulation, Gene regulatory network modelling somitogenesis, Human papillomavirus infection - Homo sapiens (human), Kidney development, Nephron development, Notch, Notch Signaling, Notch signaling pathway - Homo sapiens (human), Other types of O-glycan biosynthesis - Homo sapiens (human), Pre-NOTCH Expression and Processing, Pre-NOTCH Processing in Golgi, Signal Transduction, Signaling by NOTCH, Somitogenesis, Somitogenesis in the context of spondylocostal dysostosis, segmentation clock
UniProt: Q8NES3
Entrez ID: 3955
|
Does Knockout of TMEM14A in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
TMEM14A
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: TMEM14A (transmembrane protein 14A)
Type: protein-coding
Summary: Involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Located in endoplasmic reticulum membrane and mitochondrial membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q9Y6G1
Entrez ID: 28978
|
Does Knockout of CRHR2 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
CRHR2
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: CRHR2 (corticotropin releasing hormone receptor 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell surface receptor signaling pathway, cellular response to corticotropin-releasing hormone stimulus, hormone-mediated signaling pathway, long-term synaptic potentiation, signal transduction; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, corticotrophin-releasing factor receptor activity, corticotropin-releasing hormone receptor activity, peptide hormone binding, protein binding, transmembrane signaling receptor activity; CC: axon terminus, dendrite, membrane, plasma membrane
Pathways: CRH, Class B/2 (Secretin family receptors), Corticotropin-releasing hormone signaling pathway, Cushing syndrome - Homo sapiens (human), GPCR ligand binding, GPCRs, Class B Secretin-like, Neuroactive ligand-receptor interaction - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q13324
Entrez ID: 1395
|
Does Knockout of MAMLD1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
MAMLD1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: MAMLD1 (mastermind like domain containing 1)
Type: protein-coding
Summary: This gene encodes a mastermind-like domain containing protein. This protein may function as a transcriptional co-activator. Mutations in this gene are the cause of X-linked hypospadias type 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010].
Gene Ontology: BP: male gonad development, regulation of transcription by RNA polymerase II, spermatid differentiation, spermatogenesis; CC: Golgi apparatus, centrosome, nuclear body, nucleoplasm, nucleus
Pathways: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Formation of paraxial mesoderm, Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, NOTCH1 Intracellular Domain Regulates Transcription, NOTCH2 intracellular domain regulates transcription, NOTCH3 Intracellular Domain Regulates Transcription, NOTCH4 Intracellular Domain Regulates Transcription, Notch-HLH transcription pathway, Pre-NOTCH Expression and Processing, Pre-NOTCH Transcription and Translation, RNA Polymerase II Transcription, RUNX3 regulates NOTCH signaling, Regulation of beta-cell development, Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by NOTCH4, Transcriptional regulation by RUNX3
UniProt: Q13495
Entrez ID: 10046
|
Does Knockout of CCNK in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
CCNK
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CCNK (cyclin K)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, cell division, host-mediated suppression of viral genome replication, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of cell cycle, regulation of cyclin-dependent protein serine/threonine kinase activity, regulation of signal transduction, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein binding, protein kinase binding; CC: cyclin K-CDK12 complex, cyclin K-CDK13 complex, cyclin-dependent protein kinase holoenzyme complex, cyclin/CDK positive transcription elongation factor complex, nucleoplasm, nucleus
Pathways: Direct p53 effectors, Male infertility
UniProt: O75909
Entrez ID: 8812
|
Does Knockout of RPP21 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
RPP21
|
cell proliferation
|
Melanoma Cell Line
|
Gene: RPP21 (ribonuclease P subunit p21)
Type: protein-coding
Summary: RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009].
Gene Ontology: BP: RNA processing, response to xenobiotic stimulus, tRNA 5'-leader removal, tRNA processing; MF: RNA binding, metal ion binding, protein binding, ribonuclease P RNA binding, ribonuclease P activity; CC: endoribonuclease complex, multimeric ribonuclease P complex, nucleolar ribonuclease P complex, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, RNA transport - Homo sapiens (human), rRNA processing, rRNA processing in the nucleus and cytosol, tRNA processing, tRNA processing in the nucleus
UniProt: Q9H633
Entrez ID: 79897
|
Does Knockout of C7orf57 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
C7orf57
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: C7orf57 (chromosome 7 open reading frame 57)
Type: protein-coding
Summary: chromosome 7 open reading frame 57
Gene Ontology:
Pathways:
UniProt: Q8NEG2
Entrez ID: 136288
|
Does Knockout of DEFB130A in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
DEFB130A
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: DEFB130A (defensin beta 130A)
Type: protein-coding
Summary: Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 8p23. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cell chemotaxis, cytolysis by host of symbiont cells, defense response, defense response to bacterium, defense response to other organism, defense response to protozoan, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity; CC: cytosol, extracellular region, extracellular space
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: P0DP74
Entrez ID: 245940
|
Does Knockout of RAD17 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 1
| 1,339
|
Knockout
|
RAD17
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: RAD17 (RAD17 checkpoint clamp loader component)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, DNA replication checkpoint signaling, chromatin organization, mitotic DNA replication checkpoint signaling, mitotic intra-S DNA damage checkpoint signaling, negative regulation of DNA replication, protein localization to site of double-strand break, regulation of phosphorylation; MF: ATP binding, DNA clamp loader activity, chromatin binding, chromatin-protein adaptor activity, nucleotide binding, protein binding; CC: Rad17 RFC-like complex, chromosome, chromosome, telomeric region, nucleolus, nucleoplasm, nucleus, site of double-strand break
Pathways: ATM pathway, ATR signaling pathway, Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, DNA Double-Strand Break Repair, DNA Repair, DNA damage response, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Fanconi anemia pathway, G2/M Checkpoints, G2/M DNA damage checkpoint, Gastric Cancer Network 2, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Impaired BRCA2 binding to RAD51, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcriptional Regulation by TP53, miRNA regulation of DNA damage response, role of brca1 brca2 and atr in cancer susceptibility
UniProt: O75943
Entrez ID: 5884
|
Does Knockout of MOGAT3 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
MOGAT3
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: MOGAT3 (monoacylglycerol O-acyltransferase 3)
Type: protein-coding
Summary: Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: glycerol metabolic process, lipid metabolic process, monoacylglycerol biosynthetic process, triglyceride biosynthetic process; MF: 2-acylglycerol O-acyltransferase activity, O-acyltransferase activity, acyltransferase activity, diacylglycerol O-acyltransferase activity, protein binding, transferase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, perinuclear endoplasmic reticulum membrane, perinuclear region of cytoplasm
Pathways: Fat digestion and absorption - Homo sapiens (human), Glycerolipid metabolism - Homo sapiens (human), Triacylglyceride synthesis, triacylglycerol biosynthesis
UniProt: Q86VF5
Entrez ID: 346606
|
Does Activation of RTN4R in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
RTN4R
|
response to virus
|
Hepatoma Cell Line
|
Gene: RTN4R (reticulon 4 receptor)
Type: protein-coding
Summary: This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: axonogenesis, cell surface receptor signaling pathway, corpus callosum development, negative regulation of axon extension, negative regulation of axon regeneration, negative regulation of neuron projection development, neuronal signal transduction, positive regulation of GTPase activity, positive regulation of Rho protein signal transduction, regulation of postsynapse assembly, regulation of synapse assembly; MF: chondroitin sulfate binding, ganglioside GM1 binding, ganglioside GT1b binding, heparin binding, lipid binding, neuregulin receptor activity, protein binding, signaling receptor activity; CC: axon, axonal growth cone, cell projection, cell surface, dendrite, dendritic shaft, endoplasmic reticulum, external side of plasma membrane, extracellular exosome, glutamatergic synapse, growth cone, membrane, membrane raft, neuron projection, neuronal cell body, perikaryon, plasma membrane, side of membrane
Pathways: 22q11.2 copy number variation syndrome, Axonal growth inhibition (RHOA activation), Death Receptor Signaling, Signal Transduction, Spinal Cord Injury, p75 NTR receptor-mediated signalling, p75(NTR)-mediated signaling, p75NTR regulates axonogenesis
UniProt: Q9BZR6
Entrez ID: 65078
|
Does Knockout of SHPK in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
SHPK
|
cell proliferation
|
Melanoma Cell Line
|
Gene: SHPK (sedoheptulokinase)
Type: protein-coding
Summary: The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate metabolic process, cellular response to interleukin-13, cellular response to interleukin-4, cellular response to lipopolysaccharide, pentose-phosphate shunt, pentose-phosphate shunt, non-oxidative branch, phosphorylation, regulation of inflammatory response, regulation of macrophage activation; MF: ATP binding, kinase activity, nucleotide binding, protein binding, sedoheptulokinase activity, transferase activity; CC: cytoplasm, cytosol
Pathways: Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Pentose phosphate pathway
UniProt: Q9UHJ6
Entrez ID: 23729
|
Does Knockout of PPP2CA in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
PPP2CA
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: PPP2CA (protein phosphatase 2 catalytic subunit alpha)
Type: protein-coding
Summary: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA polymerase II transcription initiation surveillance, T cell homeostasis, intracellular signal transduction, meiotic cell cycle, mesoderm development, mitotic cell cycle, negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial to mesenchymal transition, negative regulation of glycolytic process through fructose-6-phosphate, negative regulation of hippo signaling, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, peptidyl-threonine dephosphorylation, positive regulation of NLRP3 inflammasome complex assembly, protein dephosphorylation, regulation of G1/S transition of mitotic cell cycle, regulation of cell differentiation, regulation of growth, regulation of microtubule polymerization, regulation of transcription by RNA polymerase II, response to lead ion, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, vascular endothelial cell response to oscillatory fluid shear stress; MF: GABA receptor binding, RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity, RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity, hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein heterodimerization activity, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, tau protein binding; CC: FAR/SIN/STRIPAK complex, INTAC complex, chromatin, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, extracellular exosome, membrane, membrane raft, microtubule cytoskeleton, mitochondrion, nucleus, plasma membrane, protein phosphatase type 2A complex, protein serine/threonine phosphatase complex, spindle pole, synapse
Pathways: 16p11.2 proximal deletion syndrome, AMPK signaling pathway - Homo sapiens (human), ATR signaling pathway, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Association Between Physico-Chemical Features and Toxicity Associated Pathways, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), Brain-derived neurotrophic factor (BDNF) signaling pathway, C-MYC pathway, Cancer immunotherapy by CTLA4 blockade, Chagas disease - Homo sapiens (human), Dopamine metabolism, Dopaminergic synapse - Homo sapiens (human), ErbB1 downstream signaling, FGFR3 signaling in chondrocyte proliferation and terminal differentiation, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glycogen Synthesis and Degradation, Hepatitis C - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IL3, IL8- and CXCR2-mediated signaling events, Long-term depression - Homo sapiens (human), Mesodermal commitment pathway, Oocyte meiosis - Homo sapiens (human), PDGFR-beta signaling pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PLK1 signaling events, Regulation of retinoblastoma protein, Sphingolipid pathway, Sphingolipid signaling pathway - Homo sapiens (human), TGF-beta receptor signaling, TGF-beta signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, Tight junction - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, Wnt, Wnt signaling pathway and pluripotency, akt signaling pathway, mRNA surveillance pathway - Homo sapiens (human), p53 pathway, regulation of eif-4e and p70s6 kinase
UniProt: P67775
Entrez ID: 5515
|
Does Knockout of KANSL3 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
KANSL3
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: KANSL3 (KAT8 regulatory NSL complex subunit 3)
Type: protein-coding
Summary: Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in nucleoplasm. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of mitochondrial transcription; CC: NSL complex, cytoplasm, cytoskeleton, histone acetyltransferase complex, microtubule, mitochondrion, nucleoplasm, nucleus, spindle pole
Pathways: Chromatin modifying enzymes, Chromatin organization, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), HATs acetylate histones
UniProt: Q9P2N6
Entrez ID: 55683
|
Does Knockout of TMA7 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
TMA7
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: TMA7 (translation machinery associated 7 homolog)
Type: protein-coding
Summary: Predicted to be involved in cytoplasmic translation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q9Y2S6
Entrez ID: 51372
|
Does Knockout of XRCC6 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
XRCC6
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: XRCC6 (X-ray repair cross complementing 6)
Type: protein-coding
Summary: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, activation of innate immune response, cellular hyperosmotic salinity response, cellular response to X-ray, cellular response to gamma radiation, double-strand break repair via classical nonhomologous end joining, double-strand break repair via nonhomologous end joining, immune system process, innate immune response, negative regulation of DNA-templated transcription, negative regulation of macromolecule biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of immune system process, positive regulation of lymphocyte differentiation, positive regulation of protein kinase activity, positive regulation of transcription by RNA polymerase II, recombinational repair, regulation of smooth muscle cell proliferation, response to ionizing radiation, telomere maintenance; MF: 5'-deoxyribose-5-phosphate lyase activity, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, DNA binding, DNA end binding, DNA helicase activity, RNA binding, catalytic activity, cyclin binding, damaged DNA binding, double-stranded DNA binding, double-stranded telomeric DNA binding, helicase activity, hydrolase activity, lyase activity, nucleotide binding, protein binding, protein-containing complex binding, scaffold protein binding, telomeric DNA binding, transcription cis-regulatory region binding; CC: DNA-dependent protein kinase complex, DNA-dependent protein kinase-DNA ligase 4 complex, Ku70:Ku80 complex, chromosome, chromosome, telomeric region, cytoplasm, cytosol, extracellular region, ficolin-1-rich granule lumen, membrane, nonhomologous end joining complex, nuclear telomere cap complex, nucleolus, nucleoplasm, nucleus, protein-DNA complex, protein-containing complex, secretory granule lumen, transcription regulator complex
Pathways: 2-LTR circle formation, AndrogenReceptor, BARD1 signaling events, Coregulation of Androgen receptor activity, Cytosolic sensors of pathogen-associated DNA , DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, DNA-PK pathway in nonhomologous end joining, Disease, Early Phase of HIV Life Cycle, HIV Infection, HIV Life Cycle, IRF3-mediated induction of type I IFN, Immune System, Infectious disease, Innate Immune System, Integration of provirus, Neutrophil degranulation, Non-homologous end joining, Non-homologous end-joining - Homo sapiens (human), Nonhomologous End-Joining (NHEJ), Regulation of Telomerase, STING mediated induction of host immune responses, Signaling events mediated by HDAC Class III, Viral Infection Pathways, telomeres telomerase cellular aging and immortality
UniProt: P12956
Entrez ID: 2547
|
Does Knockout of MAGOH in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
MAGOH
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MAGOH (mago homolog, exon junction complex subunit)
Type: protein-coding
Summary: Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of alternative mRNA splicing, via spliceosome, regulation of mRNA processing, regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of translation; MF: RNA binding, protein binding; CC: catalytic step 2 spliceosome, cytoplasm, cytosol, exon-exon junction complex, exon-exon junction subcomplex mago-y14, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Axon guidance, Developmental Biology, Gene expression (Transcription), Metabolism of RNA, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, RNA transport - Homo sapiens (human), Regulation of expression of SLITs and ROBOs, Signaling by ROBO receptors, Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Homo sapiens (human)
UniProt: P61326
Entrez ID: 4116
|
Does Knockout of CENPN in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
CENPN
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: CENPN (centromere protein N)
Type: protein-coding
Summary: The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: CENP-A containing chromatin assembly, chromosome segregation; CC: chromosome, chromosome, centromeric region, cytosol, inner kinetochore, kinetochore, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q96H22
Entrez ID: 55839
|
Does Knockout of ISCA1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
ISCA1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ISCA1 (iron-sulfur cluster assembly 1)
Type: protein-coding
Summary: ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: iron-sulfur cluster assembly, protein maturation; MF: 2 iron, 2 sulfur cluster binding, iron-sulfur cluster binding, metal ion binding, protein binding; CC: cytoplasm, mitochondrial [4Fe-4S] assembly complex, mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis
UniProt: Q9BUE6
Entrez ID: 81689
|
Does Knockout of TOP1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
TOP1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: TOP1 (DNA topoisomerase I)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, DNA topological change, animal organ regeneration, cellular response to luteinizing hormone stimulus, chromatin remodeling, chromosome segregation, circadian regulation of gene expression, circadian rhythm, embryonic cleavage, peptidyl-serine phosphorylation, programmed cell death, rRNA transcription, response to cAMP, response to gamma radiation, response to temperature stimulus, response to xenobiotic stimulus, rhythmic process; MF: ATP binding, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin DNA binding, chromatin binding, double-stranded DNA binding, isomerase activity, protein binding, protein domain specific binding, protein serine/threonine kinase activity, protein-containing complex binding, single-stranded DNA binding, supercoiled DNA binding; CC: P-body, chromosome, cytoplasm, dense fibrillar component, fibrillar center, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, perikaryon, protein-DNA complex
Pathways: AndrogenReceptor, Caspase Cascade in Apoptosis, Ebola Virus Pathway on Host, Irinotecan Action Pathway, Irinotecan Metabolism Pathway, Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins
UniProt: P11387
Entrez ID: 7150
|
Does Knockout of E2F5 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
E2F5
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: E2F5 (E2F transcription factor 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: animal organ morphogenesis, cell projection organization, positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, fibrillar center, nucleolus, nucleoplasm, nucleus, transcription regulator complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular senescence - Homo sapiens (human), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , E2F transcription factor network, G0 and Early G1, G1 Phase, G1/S Transition, G1/S-Specific Transcription, Gene expression (Transcription), Generic Transcription Pathway, Mitotic G1 phase and G1/S transition, Pre-implantation embryo, RNA Polymerase II Transcription, S Phase, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Signal Transduction, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Spinal Cord Injury, TGF-beta Signaling Pathway, TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, Transcription of E2F targets under negative control by DREAM complex, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
UniProt: Q15329
Entrez ID: 1875
|
Does Knockout of RCBTB2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
RCBTB2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RCBTB2 (RCC1 and BTB domain containing protein 2)
Type: protein-coding
Summary: This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].
Gene Ontology: BP: cell population proliferation, digestive tract development, liver development, lymph node development, spleen development; MF: guanyl-nucleotide exchange factor activity, protein binding; CC: acrosomal vesicle, cytoplasm, cytoplasmic vesicle
Pathways:
UniProt: O95199
Entrez ID: 1102
|
Does Knockout of NMD3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
NMD3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NMD3 (NMD3 ribosome export adaptor)
Type: protein-coding
Summary: Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: positive regulation of RNA biosynthetic process, positive regulation of protein localization to nucleolus, protein transport, ribosomal large subunit export from nucleus; MF: RNA binding, protein-macromolecule adaptor activity, ribosomal large subunit binding; CC: cytoplasm, membrane, nucleolus, nucleoplasm, nucleus
Pathways: RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q96D46
Entrez ID: 51068
|
Does Knockout of HNRNPU in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
HNRNPU
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: HNRNPU (heterogeneous nuclear ribonucleoprotein U)
Type: protein-coding
Summary: This gene encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The encoded protein has affinity for both RNA and DNA, and binds scaffold-attached region (SAR) DNA. Mutations in this gene have been associated with epileptic encephalopathy, early infantile, 54. A pseudogene of this gene has been identified on chromosome 14. [provided by RefSeq, Jun 2017].
Gene Ontology: BP: CRD-mediated mRNA stabilization, RNA localization to chromatin, RNA processing, RNA splicing, adaptive thermogenesis, alternative mRNA splicing, via spliceosome, cardiac muscle cell development, cell differentiation, cell division, cellular response to glucocorticoid stimulus, cellular response to leukemia inhibitory factor, chromatin organization, circadian regulation of gene expression, dendritic transport of messenger ribonucleoprotein complex, dosage compensation by inactivation of X chromosome, erythrocyte differentiation, mRNA metabolic process, mRNA processing, mRNA splicing, via spliceosome, mRNA stabilization, maintenance of protein location in nucleus, negative regulation of kinase activity, negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, negative regulation of stem cell differentiation, negative regulation of telomere maintenance via telomerase, negative regulation of transcription by RNA polymerase II, negative regulation of transcription elongation by RNA polymerase II, osteoblast differentiation, positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity, positive regulation of attachment of mitotic spindle microtubules to kinetochore, positive regulation of brown fat cell differentiation, positive regulation of cytoplasmic translation, positive regulation of macromolecule biosynthetic process, positive regulation of stem cell proliferation, positive regulation of transcription by RNA polymerase II, protein localization to spindle microtubule, random inactivation of X chromosome, regulation of alternative mRNA splicing, via spliceosome, regulation of chromatin organization, regulation of gene expression, regulation of mitotic cell cycle, regulation of mitotic spindle assembly, regulatory ncRNA-mediated heterochromatin formation, rhythmic process; MF: ATP binding, DNA binding, RNA binding, RNA polymerase II C-terminal domain binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II complex binding, TFIIH-class transcription factor complex binding, actin binding, chromatin DNA binding, chromatin binding, double-stranded DNA binding, double-stranded RNA binding, identical protein binding, lncRNA binding, mRNA 3'-UTR binding, nucleotide binding, piRNA binding, poly(A) binding, poly(C) RNA binding, poly(G) binding, pre-mRNA binding, promoter-specific chromatin binding, protein binding, protein-containing complex binding, ribonucleoprotein complex binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, single-stranded DNA binding, single-stranded RNA binding, snRNA binding, telomerase RNA binding, transcription corepressor activity; CC: CRD-mediated mRNA stability complex, RNA polymerase II transcription regulator complex, catalytic step 2 spliceosome, cell surface, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoskeleton, cytosol, dendrite, inactive sex chromosome, kinetochore, membrane, midbody, mitotic spindle, mitotic spindle microtubule, mitotic spindle midzone, nuclear chromosome, nuclear matrix, nuclear speck, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, spindle, spindle pole, spliceosomal complex, telomerase holoenzyme complex
Pathways: Adipogenesis, Developmental Biology, LncRNA involvement in canonical Wnt signaling and colorectal cancer, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), Transcriptional regulation of brown and beige adipocyte differentiation, Transcriptional regulation of brown and beige adipocyte differentiation by EBF2, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q00839
Entrez ID: 3192
|
Does Knockout of MIR548AE2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
MIR548AE2
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: MIR548AE2 (microRNA 548ae-2)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100616339
|
Does Knockout of CSF2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
CSF2
|
cell proliferation
|
Cancer Cell Line
|
Gene: CSF2 (colony stimulating factor 2)
Type: protein-coding
Summary: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: cell population proliferation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cellular response to lipopolysaccharide, dendritic cell differentiation, embryonic placenta development, epithelial fluid transport, granulocyte-macrophage colony-stimulating factor signaling pathway, histamine secretion, immune response, macrophage differentiation, monocyte differentiation, myeloid cell differentiation, myeloid dendritic cell differentiation, negative regulation of DNA-templated transcription, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, neutrophil differentiation, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of gene expression, positive regulation of interleukin-23 production, positive regulation of leukocyte proliferation, positive regulation of macrophage derived foam cell differentiation, positive regulation of podosome assembly, regulation of cell population proliferation, regulation of circadian sleep/wake cycle, sleep, regulation of developmental process, regulation of gene expression, regulation of signal transduction, response to fluid shear stress, response to silicon dioxide, signal transduction; MF: cytokine activity, granulocyte macrophage colony-stimulating factor receptor binding, growth factor activity, protein binding; CC: extracellular region, extracellular space, granulocyte macrophage colony-stimulating factor receptor complex, plasma membrane
Pathways: AP-1 transcription factor network, Acute myeloid leukemia - Homo sapiens (human), Alpha9 beta1 integrin signaling events, Amoebiasis - Homo sapiens (human), Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Calcium signaling in the CD4+ TCR pathway, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Cytokines and Inflammatory Response, Development of pulmonary dendritic cells and macrophage subsets, Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), GMCSF-mediated signaling events, Gene expression (Transcription), Generic Transcription Pathway, Glucocorticoid receptor regulatory network, Hematopoietic cell lineage - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), IL-17 signaling pathway - Homo sapiens (human), Immune System, Interleukin receptor SHC signaling, Interleukin-10 signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, JAK-STAT signaling pathway - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Lung fibrosis, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Photodynamic therapy-induced NF-kB survival signaling, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of myeloid cells, Regulation of retinoblastoma protein, Rheumatoid arthritis - Homo sapiens (human), Selective expression of chemokine receptors during T-cell polarization, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Interleukins, Syndecan-2-mediated signaling events, T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, TNF signaling pathway - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), Transcriptional regulation by RUNX1
UniProt: P04141
Entrez ID: 1437
|
Does Knockout of SLC16A10 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
SLC16A10
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: SLC16A10 (solute carrier family 16 member 10)
Type: protein-coding
Summary: SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: amino acid transmembrane transport, amino acid transport, aromatic amino acid transport, carboxylic acid transmembrane transport, phenylalanine transport, thyroid hormone generation, thyroid hormone transport, thyroid-stimulating hormone secretion, transmembrane transport, tryptophan transport, tyrosine transport; MF: L-phenylalanine transmembrane transporter activity, L-tryptophan transmembrane transporter activity, L-tyrosine transmembrane transporter activity, amino acid transmembrane transporter activity, aromatic amino acid transmembrane transporter activity, carboxylic acid transmembrane transporter activity, protein binding, thyroid hormone transmembrane transporter activity, transmembrane transporter activity; CC: basolateral plasma membrane, cell junction, membrane, plasma membrane
Pathways: Amino acid transport across the plasma membrane, Protein digestion and absorption - Homo sapiens (human), Proximal tubule transport, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, Transport of small molecules
UniProt: Q8TF71
Entrez ID: 117247
|
Does Knockout of MRGPRX4 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
MRGPRX4
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MRGPRX4 (MAS related GPR family member X4)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within chemosensory behavior and hematopoietic progenitor cell differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q96LA9
Entrez ID: 117196
|
Does Knockout of BCAM in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
BCAM
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: BCAM (basal cell adhesion molecule (Lutheran blood group))
Type: protein-coding
Summary: This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: angiogenesis, cell adhesion, cell-matrix adhesion, signal transduction; MF: laminin binding, laminin receptor activity, protein binding, transmembrane signaling receptor activity; CC: cell surface, external side of plasma membrane, extracellular exosome, extracellular matrix, extracellular region, membrane, plasma membrane
Pathways:
UniProt: P50895
Entrez ID: 4059
|
Does Knockout of PCK1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
PCK1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: PCK1 (phosphoenolpyruvate carboxykinase 1)
Type: protein-coding
Summary: This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: NLS-bearing protein import into nucleus, SREBP-SCAP complex retention in endoplasmic reticulum, cellular response to dexamethasone stimulus, cellular response to glucose stimulus, cellular response to insulin stimulus, cellular response to potassium ion starvation, dicarboxylic acid metabolic process, gluconeogenesis, glucose homeostasis, glucose metabolic process, glyceraldehyde-3-phosphate biosynthetic process, glycerol biosynthetic process from pyruvate, hepatocyte differentiation, lipid metabolic process, oxaloacetate metabolic process, peptidyl-serine phosphorylation, positive regulation of cholesterol biosynthetic process, positive regulation of lipid biosynthetic process, positive regulation of memory T cell differentiation, positive regulation of transcription by RNA polymerase II, propionate catabolic process, protein maturation, regulation of lipid biosynthetic process, response to bacterium, response to insulin, response to starvation, tricarboxylic acid metabolic process; MF: GTP binding, carboxy-lyase activity, carboxylic acid binding, kinase activity, lyase activity, magnesium ion binding, manganese ion binding, metal ion binding, nucleotide binding, phosphoenolpyruvate carboxykinase (GTP) activity, phosphoenolpyruvate carboxykinase activity, protein serine kinase activity (using GTP as donor), purine nucleotide binding, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, mitochondrion
Pathways: AMPK signaling pathway - Homo sapiens (human), Abacavir ADME, Abacavir metabolism, Adipocytokine signaling pathway - Homo sapiens (human), Adipogenesis, Amino Acid metabolism, Angiopoietin Like Protein 8 Regulatory Pathway, Citrate cycle (TCA cycle) - Homo sapiens (human), Developmental Biology, Drug ADME, Estrogen Receptor Pathway, FOXA2 and FOXA3 transcription factor networks, FOXO-mediated transcription, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, FoxO signaling pathway - Homo sapiens (human), Fructose-1,6-diphosphatase deficiency, Gene expression (Transcription), Generic Transcription Pathway, Glucagon signaling pathway - Homo sapiens (human), Gluconeogenesis, Glucose metabolism, Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, Insulin resistance - Homo sapiens (human), Insulin signaling pathway - Homo sapiens (human), Leigh Syndrome, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis , NR1H2 and NR1H3-mediated signaling, Nuclear Receptors Meta-Pathway, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PPAR signaling pathway, PPAR signaling pathway - Homo sapiens (human), Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Primary hyperoxaluria II, PH2, Proximal tubule bicarbonate reclamation - Homo sapiens (human), Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency), Pyruvate Dehydrogenase Complex Deficiency, Pyruvate Metabolism, Pyruvate kinase deficiency, Pyruvate metabolism - Homo sapiens (human), RNA Polymerase II Transcription, Signal Transduction, Signaling by Nuclear Receptors, TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc), Transcriptional regulation of white adipocyte differentiation, Triosephosphate isomerase, gluconeogenesis
UniProt: P35558
Entrez ID: 5105
|
Does Knockout of CLK4 in Lung Cancer Cell Line causally result in response to virus?
| 1
| 1,433
|
Knockout
|
CLK4
|
response to virus
|
Lung Cancer Cell Line
|
Gene: CLK4 (CDC like kinase 4)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: regulation of RNA splicing; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: nucleus
Pathways: Legionellosis - Homo sapiens (human), mRNA Processing
UniProt: Q9HAZ1
Entrez ID: 57396
|
Does Knockout of UROD in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
UROD
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: UROD (uroporphyrinogen decarboxylase)
Type: protein-coding
Summary: This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010].
Gene Ontology: BP: heme A biosynthetic process, heme B biosynthetic process, heme O biosynthetic process, heme biosynthetic process, heme metabolic process, porphyrin-containing compound biosynthetic process, porphyrin-containing compound catabolic process, porphyrin-containing compound metabolic process, protoporphyrinogen IX biosynthetic process; MF: carboxy-lyase activity, lyase activity, protein binding, uroporphyrinogen decarboxylase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Acute Intermittent Porphyria, Congenital Erythropoietic Porphyria (CEP) or Gunther Disease, Heme Biosynthesis, Heme biosynthesis, Hereditary Coproporphyria (HCP), Metabolism, Metabolism of porphyrins, Porphyria Variegata (PV), Porphyrin Metabolism, Porphyrin and chlorophyll metabolism - Homo sapiens (human), heme biosynthesis, heme biosynthesis from uroporphyrinogen-III I, hemoglobins chaperone
UniProt: P06132
Entrez ID: 7389
|
Does Knockout of SOAT1 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
SOAT1
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: SOAT1 (sterol O-acyltransferase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, cholesterol storage, lipid metabolic process, low-density lipoprotein particle clearance, macrophage derived foam cell differentiation, positive regulation of amyloid precursor protein biosynthetic process, steroid metabolic process, very-low-density lipoprotein particle assembly; MF: O-acyltransferase activity, acyltransferase activity, cholesterol O-acyltransferase activity, cholesterol binding, fatty-acyl-CoA binding, identical protein binding, protein binding, sterol O-acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Alendronate Action Pathway, Atorvastatin Action Pathway, CHILD Syndrome, Cerivastatin Action Pathway, Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways), Cholesterol metabolism - Homo sapiens (human), Cholesteryl ester storage disease, Chondrodysplasia Punctata II, X Linked Dominant (CDPX2), Desmosterolosis, Fluvastatin Action Pathway, Hyper-IgD syndrome, Hypercholesterolemia, Ibandronate Action Pathway, LDL clearance, Lovastatin Action Pathway, Lysosomal Acid Lipase Deficiency (Wolman Disease), Mevalonic aciduria, Pamidronate Action Pathway, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Pravastatin Action Pathway, Risedronate Action Pathway, Rosuvastatin Action Pathway, Simvastatin Action Pathway, Smith-Lemli-Opitz Syndrome (SLOS), Statin inhibition of cholesterol production, Steroid Biosynthesis, Steroid biosynthesis - Homo sapiens (human), Transport of small molecules, Wolman disease, Zoledronate Action Pathway
UniProt: P35610
Entrez ID: 6646
|
Does Knockout of UGT2B11 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
UGT2B11
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: UGT2B11 (UDP glucuronosyltransferase family 2 member B11)
Type: protein-coding
Summary: Enables glucuronosyltransferase activity. Involved in estrogen metabolic process and xenobiotic glucuronidation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: estrogen metabolic process, xenobiotic metabolic process; MF: UDP-glycosyltransferase activity, glucuronosyltransferase activity, glycosyltransferase activity, protein binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: 17-Beta Hydroxysteroid Dehydrogenase III Deficiency, Acute Intermittent Porphyria, Androgen and Estrogen Metabolism, Aromatase deficiency, Ascorbate and aldarate metabolism - Homo sapiens (human), Aspirin ADME, Bile secretion - Homo sapiens (human), Biological oxidations, Chemical carcinogenesis - Homo sapiens (human), Congenital Erythropoietic Porphyria (CEP) or Gunther Disease, Drug ADME, Drug metabolism - cytochrome P450 - Homo sapiens (human), Drug metabolism - other enzymes - Homo sapiens (human), Glucuronidation, Glycogen synthetase deficiency, Glycogenosis, Type III. Cori disease, Debrancher glycogenosis, Glycogenosis, Type IV. Amylopectinosis, Anderson disease, Glycogenosis, Type VI. Hers disease, Hereditary Coproporphyria (HCP), Metabolism, Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human), Metapathway biotransformation Phase I and II, Mucopolysaccharidosis VI. Sly syndrome, Pentose and glucuronate interconversions - Homo sapiens (human), Phase II - Conjugation of compounds, Porphyria Variegata (PV), Porphyrin Metabolism, Porphyrin and chlorophyll metabolism - Homo sapiens (human), Retinol metabolism - Homo sapiens (human), Starch and Sucrose Metabolism, Steroid hormone biosynthesis - Homo sapiens (human), Sucrase-isomaltase deficiency, melatonin degradation I, nicotine degradation III, nicotine degradation IV, serotonin degradation, superpathway of melatonin degradation, superpathway of tryptophan utilization, thyroid hormone metabolism II (via conjugation and/or degradation)
UniProt: O75310
Entrez ID: 10720
|
Does Knockout of DNAAF1 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
DNAAF1
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: DNAAF1 (dynein axonemal assembly factor 1)
Type: protein-coding
Summary: The protein encoded by this gene is cilium-specific and is required for the stability of the ciliary architecture. It is involved in the regulation of microtubule-based cilia and actin-based brush border microvilli. Mutations in this gene are associated with primary ciliary dyskinesia-13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: axonemal dynein complex assembly, axoneme assembly, cilium assembly, cilium movement, determination of digestive tract left/right asymmetry, determination of liver left/right asymmetry, determination of pancreatic left/right asymmetry, epithelial cilium movement involved in determination of left/right asymmetry, heart looping, inner dynein arm assembly, left/right pattern formation, lung development, motile cilium assembly, outer dynein arm assembly, regulation of cilium beat frequency; MF: dynein complex binding; CC: axoneme, cell projection, cilium, cytoplasm, cytoskeleton, extracellular region, spindle pole
Pathways: Ciliopathies
UniProt: Q8NEP3
Entrez ID: 123872
|
Does Knockout of IL12RB2 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
IL12RB2
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: IL12RB2 (interleukin 12 receptor subunit beta 2)
Type: protein-coding
Summary: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: T-helper 1 cell differentiation, cell surface receptor signaling pathway, cytokine-mediated signaling pathway, interleukin-12-mediated signaling pathway, positive regulation of cell population proliferation, positive regulation of type II interferon production, response to cytokine, response to lipopolysaccharide; MF: coreceptor activity, cytokine binding, cytokine receptor activity, protein kinase binding; CC: external side of plasma membrane, membrane, plasma membrane, receptor complex
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Developmental Biology, Differentiation of T cells, Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells), IL12-mediated signaling events, IL27-mediated signaling events, Immune System, Inflammatory bowel disease - Homo sapiens (human), Interleukin-12 family signaling, Interleukin-12 signaling, Interleukin-35 Signalling, JAK-STAT signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Regulatory circuits of the STAT3 signaling pathway, Selective expression of chemokine receptors during T-cell polarization, Signaling by Interleukins, Th1 and Th2 cell differentiation - Homo sapiens (human), il12 and stat4 dependent signaling pathway in th1 development, no2-dependent il-12 pathway in nk cells
UniProt: Q99665
Entrez ID: 3595
|
Does Knockout of TUBGCP4 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 519
|
Knockout
|
TUBGCP4
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: TUBGCP4 (tubulin gamma complex component 4)
Type: protein-coding
Summary: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, protein-containing complex assembly, spindle assembly; MF: gamma-tubulin binding, microtubule minus-end binding, protein binding, structural constituent of cytoskeleton; CC: centrosome, cytoplasm, cytoskeleton, cytosol, gamma-tubulin complex, gamma-tubulin ring complex, membrane, microtubule, microtubule cytoskeleton, microtubule organizing center, recycling endosome, spindle pole
Pathways: 15q11.2 copy number variation syndrome
UniProt: Q9UGJ1
Entrez ID: 27229
|
Does Knockout of RASSF1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
RASSF1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: RASSF1 (Ras association domain family member 1)
Type: protein-coding
Summary: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011].
Gene Ontology: BP: DNA damage response, Ras protein signal transduction, positive regulation of protein ubiquitination, protein stabilization, regulation of cell cycle, regulation of cell cycle G1/S phase transition, signal transduction; MF: identical protein binding, metal ion binding, protein binding, small GTPase binding, zinc ion binding; CC: centrosome, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, nucleus, spindle, spindle pole
Pathways: Bladder cancer, Bladder cancer - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Hippo signaling pathway - multiple species - Homo sapiens (human), Hippo-Yap signaling pathway, MicroRNAs in cancer - Homo sapiens (human), Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), p53 pathway
UniProt: Q9NS23
Entrez ID: 11186
|
Does Knockout of VRK1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
VRK1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: VRK1 (VRK serine/threonine kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Cajal body organization, DNA damage response, Golgi disassembly, cell division, chromatin remodeling, mitotic nuclear membrane disassembly, neuron projection development, positive regulation of protein localization to chromatin, positive regulation of transcription by RNA polymerase II, protein autophosphorylation, protein phosphorylation, regulation of neuron migration, signal transduction; MF: ATP binding, histone H2AX kinase activity, histone H3S10 kinase activity, histone H3T3 kinase activity, histone binding, kinase activity, nucleosomal DNA binding, nucleotide binding, protein binding, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Cajal body, Golgi stack, chromatin, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown
UniProt: Q99986
Entrez ID: 7443
|
Does Knockout of KRT34 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
KRT34
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: KRT34 (keratin 34)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: epidermis development, epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium; MF: protein binding, structural constituent of skin epidermis, structural molecule activity; CC: cytoskeleton, cytosol, extracellular space, intermediate filament, keratin filament
Pathways: Developmental Biology, Estrogen signaling pathway - Homo sapiens (human), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Homo sapiens (human), Vitamin D Receptor Pathway
UniProt: O76011
Entrez ID: 3885
|
Does Knockout of MRPS30 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
MRPS30
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MRPS30 (mitochondrial ribosomal protein S30)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic process, mitochondrial translation, translation; MF: RNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q9NP92
Entrez ID: 10884
|
Does Knockout of SEC22A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
SEC22A
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: SEC22A (SEC22 homolog A, vesicle trafficking protein)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008].
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, membrane fusion, protein transport, vesicle-mediated transport; MF: SNAP receptor activity, protein binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q96IW7
Entrez ID: 26984
|
Does Knockout of SCAMP4 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
SCAMP4
|
cell proliferation
|
T-lymphoma cell line
|
Gene: SCAMP4 (secretory carrier membrane protein 4)
Type: protein-coding
Summary: Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011].
Gene Ontology: BP: exocytosis, protein transport; CC: membrane, recycling endosome membrane, trans-Golgi network membrane
Pathways:
UniProt: Q969E2
Entrez ID: 113178
|
Does Knockout of RPS2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
RPS2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPS2 (ribosomal protein S2)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, positive regulation of ubiquitin-protein transferase activity, translation; MF: RNA binding, cadherin binding, enzyme binding, fibroblast growth factor binding, mRNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, EGFR1, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Post-translational protein modification, Protein methylation, RMTs methylate histone arginines, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P15880
Entrez ID: 6187
|
Does Knockout of MCAM in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
MCAM
|
response to virus
|
Huh-7 Cell
|
Gene: MCAM (melanoma cell adhesion molecule)
Type: protein-coding
Summary: Involved in glomerular filtration and vascular wound healing. Acts upstream of or within angiogenesis. Located in external side of plasma membrane. Biomarker of chronic obstructive pulmonary disease and uveal melanoma. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: anatomical structure morphogenesis, angiogenesis, cell adhesion, glomerular filtration, positive regulation of cell migration, vascular wound healing; MF: laminin receptor activity, protein binding; CC: external side of plasma membrane, extracellular region, extracellular space, focal adhesion, membrane, plasma membrane
Pathways: RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOF GTPase cycle, RHOG GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: P43121
Entrez ID: 4162
|
Does Knockout of RFC5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
RFC5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RFC5 (replication factor C subunit 5)
Type: protein-coding
Summary: This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].
Gene Ontology: BP: DNA repair, DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA clamp loader activity, enzyme binding, nucleotide binding, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, chromosome, nucleoplasm, nucleus
Pathways: ATR signaling pathway, Activation of ATR in response to replication stress, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Fanconi anemia pathway, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Impaired BRCA2 binding to RAD51, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P40937
Entrez ID: 5985
|
Does Knockout of ALDH8A1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
ALDH8A1
|
cell proliferation
|
Cancer Cell Line
|
Gene: ALDH8A1 (aldehyde dehydrogenase 8 family member A1)
Type: protein-coding
Summary: This gene encodes a member of the aldehyde dehydrogenase family of proteins. The encoded protein has been implicated in the synthesis of 9-cis-retinoic acid and in the breakdown of the amino acid tryptophan. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. In addition, this enzyme has been shown to catalyze the conversion of 2-aminomuconic semialdehyde to 2-aminomuconate in the kynurenine pathway of tryptophan catabolism. [provided by RefSeq, Jul 2018].
Gene Ontology: BP: 9-cis-retinoic acid biosynthetic process, L-kynurenine catabolic process, retinal metabolic process, retinoic acid metabolic process; MF: aminomuconate-semialdehyde dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, retinal dehydrogenase (NAD+) activity; CC: cytoplasm, cytosol, extracellular exosome
Pathways: RA biosynthesis pathway, Signal Transduction, Signaling by Nuclear Receptors, Signaling by Retinoic Acid, Tryptophan metabolism - Homo sapiens (human)
UniProt: Q9H2A2
Entrez ID: 64577
|
Does Knockout of GTSE1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
GTSE1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GTSE1 (G2 and S-phase expressed 1)
Type: protein-coding
Summary: The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, microtubule-based process; MF: microtubule binding, protein binding; CC: cytoplasm, cytoplasmic microtubule, cytoskeleton, cytosol, membrane, microtubule, microtubule cytoskeleton, nucleoplasm
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, G2/M Checkpoints, G2/M Transition, Mitotic G2-G2/M phases, The role of GTSE1 in G2/M progression after G2 checkpoint, p53 signaling pathway - Homo sapiens (human)
UniProt: Q9NYZ3
Entrez ID: 51512
|
Does Knockout of PMF1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
PMF1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PMF1 (polyamine modulated factor 1)
Type: protein-coding
Summary: Enables leucine zipper domain binding activity and transcription coactivator activity. Involved in chromosome segregation. Located in Golgi apparatus; kinetochore; and nucleoplasm. Part of MIS12/MIND type complex. Implicated in bladder carcinoma and urinary bladder cancer. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, positive regulation of DNA-templated transcription, transcription by RNA polymerase II; MF: leucine zipper domain binding, protein binding, transcription coactivator activity; CC: Golgi apparatus, MIS12/MIND type complex, chromosome, chromosome, centromeric region, cytosol, kinetochore, nucleoplasm, nucleus, outer kinetochore, spindle pole, transcription regulator complex
Pathways:
UniProt: Q6P1K2
Entrez ID: 11243
|
Does Knockout of COL28A1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
COL28A1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: COL28A1 (collagen type XXVIII alpha 1 chain)
Type: protein-coding
Summary: COL28A1 belongs to a class of collagens containing von Willebrand factor (VWF; MIM 613160) type A (VWFA) domains (Veit et al., 2006 [PubMed 16330543]).[supplied by OMIM, Nov 2010].
Gene Ontology: MF: extracellular matrix structural constituent conferring tensile strength, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: basement membrane, collagen trimer, endoplasmic reticulum lumen, extracellular matrix, extracellular region
Pathways: Collagen biosynthesis and modifying enzymes, Collagen chain trimerization, Collagen formation, Extracellular matrix organization, Protein digestion and absorption - Homo sapiens (human)
UniProt: Q2UY09
Entrez ID: 340267
|
Does Knockout of PDE8A in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
PDE8A
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PDE8A (phosphodiesterase 8A)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].
Gene Ontology: BP: cAMP catabolic process, cellular response to epidermal growth factor stimulus, negative regulation of cAMP/PKA signal transduction, positive regulation of ERK1 and ERK2 cascade, regulation of DNA-templated transcription, signal transduction; MF: 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, hydrolase activity, kinase binding, metal ion binding, phosphoric diester hydrolase activity, protein kinase activator activity; CC: cytosol, extracellular exosome
Pathways: Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), G Protein Signaling Pathways, G alpha (s) signalling events, GPCR downstream signalling, Morphine addiction - Homo sapiens (human), Phosphodiesterases in neuronal function, Purine metabolism - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: O60658
Entrez ID: 5151
|
Does Knockout of FAM86B1 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
FAM86B1
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: FAM86B1 (family with sequence similarity 86 member B1 (gene/pseudogene))
Type: protein-coding
Summary: Predicted to enable methyltransferase activity. Predicted to be involved in methylation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: methyltransferase activity, protein-lysine N-methyltransferase activity, transferase activity; CC: protein-containing complex
Pathways:
UniProt: Q8N7N1
Entrez ID: 85002
|
Does Inhibition of RFX1 in Mammary Epithelial Cell Line causally result in cell proliferation?
| 0
| 2,248
|
Inhibition
|
RFX1
|
cell proliferation
|
Mammary Epithelial Cell Line
|
Gene: RFX1 (regulatory factor X1)
Type: protein-coding
Summary: This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016].
Gene Ontology: BP: immune response, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways:
UniProt: P22670
Entrez ID: 5989
|
Does Knockout of SPTY2D1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
SPTY2D1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SPTY2D1 (SPT2 chromatin protein domain containing 1)
Type: protein-coding
Summary: Enables DNA binding activity and histone binding activity. Involved in nucleosome organization; regulation of chromatin assembly; and regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: heterochromatin formation, nucleosome assembly, regulation of DNA-templated transcription, transcription by RNA polymerase I; MF: DNA binding, RNA polymerase I core binding, histone binding, histone chaperone activity, protein binding; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q68D10
Entrez ID: 144108
|
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