prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of LETM1 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | LETM1 | cell proliferation | Renal Cancer Cell Line | Gene: LETM1 (leucine zipper and EF-hand containing transmembrane protein 1)
Type: protein-coding
Summary: This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphol... |
Does Knockout of ASGR2 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | ASGR2 | response to virus | Lung Cancer Cell Line | Gene: ASGR2 (asialoglycoprotein receptor 2)
Type: protein-coding
Summary: This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycop... |
Does Knockout of RBM19 in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | RBM19 | cell proliferation | Breast Cancer Cell Line | Gene: RBM19 (RNA binding motif protein 19)
Type: protein-coding
Summary: This gene encodes a nucleolar protein that contains six RNA-binding motifs. The encoded protein may be involved in regulating ribosome biogenesis. Multiple alternatively spliced variants, encoding the same protein, have been identi... |
Does Knockout of ANXA8L1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | ANXA8L1 | cell proliferation | Colonic Cancer Cell Line | Gene: ANXA8L1 (annexin A8 like 1)
Type: protein-coding
Summary: This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overe... |
Does Knockout of OSTF1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | OSTF1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: OSTF1 (osteoclast stimulating factor 1)
Type: protein-coding
Summary: Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008].
G... |
Does Knockout of TACR3 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | TACR3 | cell proliferation | Monocytic Leukemia Cell Line | Gene: TACR3 (tachykinin receptor 3)
Type: protein-coding
Summary: This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions w... |
Does Knockout of MAST1 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | MAST1 | cell proliferation | Cancer Cell Line | Gene: MAST1 (microtubule associated serine/threonine kinase 1)
Type: protein-coding
Summary: This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density pro... |
Does Knockout of SYT12 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | SYT12 | response to chemicals | Monocytic Leukemia Cell Line | Gene: SYT12 (synaptotagmin 12)
Type: protein-coding
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat hav... |
Does Knockout of TNNC1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | TNNC1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: TNNC1 (troponin C1, slow skeletal and cardiac type)
Type: protein-coding
Summary: Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATP... |
Does Knockout of SMC4 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | SMC4 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: SMC4 (structural maintenance of chromosomes 4)
Type: protein-coding
Summary: This gene belongs to the 'structural maintenance of chromosomes' (SMC) gene family. Members of this gene family play a role in two changes in chromosome structure during mitotic segregation of chromosomes- chromosome cond... |
Does Knockout of RPS25 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 69 | Knockout | RPS25 | cell proliferation | Monocytic Leukemia Cell Line | Gene: RPS25 (ribosomal protein S25)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of PDCD4 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | PDCD4 | cell proliferation | Multiple Myeloma Cell Line | Gene: PDCD4 (programmed cell death 4)
Type: protein-coding
Summary: This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [pro... |
Does Knockout of TUBE1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 220 | Knockout | TUBE1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: TUBE1 (tubulin epsilon 1)
Type: protein-coding
Summary: This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in ... |
Does Knockout of PPP1R8 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | PPP1R8 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: PPP1R8 (protein phosphatase 1 regulatory subunit 8)
Type: protein-coding
Summary: This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not... |
Does Knockout of WDR7 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | WDR7 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: WDR7 (WD repeat domain 7)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) that may facilitate formation of heterotrimeric or multi... |
Does Knockout of SRP68 in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | SRP68 | cell proliferation | Multiple Myeloma Cell Line | Gene: SRP68 (signal recognition particle 68)
Type: protein-coding
Summary: This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RN... |
Does Knockout of CDC26 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | CDC26 | cell proliferation | Glioblastoma Cell Line | Gene: CDC26 (cell division cycle 26)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regul... |
Does Knockout of ZNF442 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | ZNF442 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ZNF442 (zinc finger protein 442)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcrip... |
Does Knockout of SGCZ in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | SGCZ | cell proliferation | Cancer Cell Line | Gene: SGCZ (sarcoglycan zeta)
Type: protein-coding
Summary: The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a s... |
Does Knockout of EPS15L1 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | EPS15L1 | cell proliferation | Gastric Cancer Cell Line | Gene: EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1)
Type: protein-coding
Summary: Enables cadherin binding activity. Predicted to be involved in endocytosis and endosomal transport. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:... |
Does Knockout of TTC33 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | TTC33 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: TTC33 (tetratricopeptide repeat domain 33)
Type: protein-coding
Summary: tetratricopeptide repeat domain 33
Gene Ontology:
Pathways:
UniProt: Q6PID6
Entrez ID: 23548 |
Does Activation of APOBEC3C in T cell causally result in protein/peptide accumulation? | 1 | 2,426 | Activation | APOBEC3C | protein/peptide accumulation | T cell | Gene: APOBEC3C (apolipoprotein B mRNA editing enzyme catalytic subunit 3C)
Type: protein-coding
Summary: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of t... |
Does Knockout of EEF2KMT in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | EEF2KMT | cell proliferation | Medulloblastoma Cell Line | Gene: EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase)
Type: protein-coding
Summary: Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr ... |
Does Knockout of KPNB1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | KPNB1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: KPNB1 (karyopherin subunit beta 1)
Type: protein-coding
Summary: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS ... |
Does Knockout of SAP30BP in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | SAP30BP | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: SAP30BP (SAP30 binding protein)
Type: protein-coding
Summary: Involved in modulation by host of symbiont transcription; positive regulation of histone deacetylation; and response to virus. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Apr... |
Does Knockout of ARL4D in Cancer Cell Line causally result in cell proliferation? | 0 | 193 | Knockout | ARL4D | cell proliferation | Cancer Cell Line | Gene: ARL4D (ARF like GTPase 4D)
Type: protein-coding
Summary: ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange ra... |
Does Knockout of RPS4X in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | RPS4X | cell proliferation | Endometrial Cancer Cell Line | Gene: RPS4X (ribosomal protein S4 X-linked)
Type: protein-coding
Summary: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. ... |
Does Knockout of SSX2IP in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 387 | Knockout | SSX2IP | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: SSX2IP (SSX family member 2 interacting protein)
Type: protein-coding
Summary: This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alte... |
Does Knockout of TAX1BP3 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | TAX1BP3 | cell proliferation | Gastric Cancer Cell Line | Gene: TAX1BP3 (Tax1 binding protein 3)
Type: protein-coding
Summary: This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor... |
Does Knockout of YEATS2 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | YEATS2 | response to chemicals | Monocytic Leukemia Cell Line | Gene: YEATS2 (YEATS domain containing 2)
Type: protein-coding
Summary: Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding d... |
Does Knockout of GART in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | GART | cell proliferation | Monocytic Leukemia Cell Line | Gene: GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase)
Type: protein-coding
Summary: The protein encoded by this gene is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycina... |
Does Knockout of ESPL1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | ESPL1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: ESPL1 (extra spindle pole bodies like 1, separase)
Type: protein-coding
Summary: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via disti... |
Does Knockout of AFTPH in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | AFTPH | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: AFTPH (aftiphilin)
Type: protein-coding
Summary: Enables clathrin binding activity. Predicted to be involved in intracellular transport. Located in Golgi apparatus; cytosol; and nucleoplasm. Part of AP-1 adaptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: ... |
Does Knockout of CHMP7 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | CHMP7 | cell proliferation | Monocytic Leukemia Cell Line | Gene: CHMP7 (charged multivesicular body protein 7)
Type: protein-coding
Summary: Involved in several processes, including late endosome to vacuole transport; midbody abscission; and mitotic nuclear division. Located in cytosol; nuclear envelope; and nucleoplasm. Part of ESCRT III complex. Colocalizes w... |
Does Knockout of TICRR in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | TICRR | cell proliferation | Glioblastoma Cell Line | Gene: TICRR (TOPBP1 interacting checkpoint and replication regulator)
Type: protein-coding
Summary: Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication,... |
Does Knockout of NSRP1 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | NSRP1 | response to virus | Hepatoma Cell Line | Gene: NSRP1 (nuclear speckle splicing regulatory protein 1)
Type: protein-coding
Summary: Enables mRNA binding activity. Involved in developmental process and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of ribonucleoprotein complex. [provided by Alliance of G... |
Does Knockout of RPAIN in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | RPAIN | cell proliferation | Medulloblastoma Cell Line | Gene: RPAIN (RPA interacting protein)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Acts upstream of or within several processes, including DNA metabolic process; protein import into nucleus; and response to UV. Located in PML body; cytoplasm; and fibrillar center. [provi... |
Does Knockout of NDUFA3 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | NDUFA3 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: NDUFA3 (NADH:ubiquinone oxidoreductase subunit A3)
Type: protein-coding
Summary: Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of mitochondrial respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:... |
Does Knockout of DYNC1H1 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | DYNC1H1 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Type: protein-coding
Summary: Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, in... |
Does Knockout of CCDC43 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | CCDC43 | cell proliferation | Renal Cancer Cell Line | Gene: CCDC43 (coiled-coil domain containing 43)
Type: protein-coding
Summary: Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q96MW1
Entrez ID: 124808 |
Does Knockout of CDC27 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | CDC27 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: CDC27 (cell division cycle 27)
Type: protein-coding
Summary: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is... |
Does Knockout of INTS4 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | INTS4 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: INTS4 (integrator complex subunit 4)
Type: protein-coding
Summary: INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U... |
Does Activation of L2HGDH in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | L2HGDH | protein/peptide accumulation | T cell | Gene: L2HGDH (L-2-hydroxyglutarate dehydrogenase)
Type: protein-coding
Summary: This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric acidu... |
Does Knockout of ANKLE2 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | ANKLE2 | cell proliferation | Endometrial Cancer Cell Line | Gene: ANKLE2 (ankyrin repeat and LEM domain containing 2)
Type: protein-coding
Summary: This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene caus... |
Does Knockout of FLT3LG in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | FLT3LG | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: FLT3LG (fms related receptor tyrosine kinase 3 ligand)
Type: protein-coding
Summary: Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly i... |
Does Knockout of CYP2W1 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | CYP2W1 | cell proliferation | Breast Cancer Cell Line | Gene: CYP2W1 (cytochrome P450 family 2 subfamily W member 1)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, ste... |
Does Knockout of LFNG in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | LFNG | cell proliferation | Colonic Cancer Cell Line | Gene: LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase)
Type: protein-coding
Summary: This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the MFNG (GeneID: 4242) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved... |
Does Knockout of TMEM14A in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | TMEM14A | cell proliferation | Breast Cancer Cell Line | Gene: TMEM14A (transmembrane protein 14A)
Type: protein-coding
Summary: Involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Located in endoplasmic reticulum membrane and mitochondrial membrane. [provided by Alliance of Genome Resource... |
Does Knockout of CRHR2 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | CRHR2 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: CRHR2 (corticotropin releasing hormone receptor 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone... |
Does Knockout of MAMLD1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | MAMLD1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: MAMLD1 (mastermind like domain containing 1)
Type: protein-coding
Summary: This gene encodes a mastermind-like domain containing protein. This protein may function as a transcriptional co-activator. Mutations in this gene are the cause of X-linked hypospadias type 2. Alternate splicing results in ... |
Does Knockout of CCNK in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | CCNK | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: CCNK (cyclin K)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of ... |
Does Knockout of RPP21 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | RPP21 | cell proliferation | Melanoma Cell Line | Gene: RPP21 (ribonuclease P subunit p21)
Type: protein-coding
Summary: RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009].
Gene Ontology: BP: RNA processing, r... |
Does Knockout of C7orf57 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | C7orf57 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: C7orf57 (chromosome 7 open reading frame 57)
Type: protein-coding
Summary: chromosome 7 open reading frame 57
Gene Ontology:
Pathways:
UniProt: Q8NEG2
Entrez ID: 136288 |
Does Knockout of DEFB130A in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | DEFB130A | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: DEFB130A (defensin beta 130A)
Type: protein-coding
Summary: Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. B... |
Does Knockout of RAD17 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 1 | 1,339 | Knockout | RAD17 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: RAD17 (RAD17 checkpoint clamp loader component)
Type: protein-coding
Summary: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This... |
Does Knockout of MOGAT3 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | MOGAT3 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: MOGAT3 (monoacylglycerol O-acyltransferase 3)
Type: protein-coding
Summary: Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008].
... |
Does Activation of RTN4R in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | RTN4R | response to virus | Hepatoma Cell Line | Gene: RTN4R (reticulon 4 receptor)
Type: protein-coding
Summary: This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in... |
Does Knockout of SHPK in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | SHPK | cell proliferation | Melanoma Cell Line | Gene: SHPK (sedoheptulokinase)
Type: protein-coding
Summary: The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this... |
Does Knockout of PPP2CA in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | PPP2CA | cell proliferation | Renal Cancer Cell Line | Gene: PPP2CA (protein phosphatase 2 catalytic subunit alpha)
Type: protein-coding
Summary: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists o... |
Does Knockout of KANSL3 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | KANSL3 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: KANSL3 (KAT8 regulatory NSL complex subunit 3)
Type: protein-coding
Summary: Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in nucleoplasm. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of TMA7 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | TMA7 | cell proliferation | Colorectal Cancer Cell Line | Gene: TMA7 (translation machinery associated 7 homolog)
Type: protein-coding
Summary: Predicted to be involved in cytoplasmic translation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q9Y2S6
Entrez ID: 51372 |
Does Knockout of XRCC6 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | XRCC6 | cell proliferation | Endometrial Cancer Cell Line | Gene: XRCC6 (X-ray repair cross complementing 6)
Type: protein-coding
Summary: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be... |
Does Knockout of MAGOH in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | MAGOH | cell proliferation | Monocytic Leukemia Cell Line | Gene: MAGOH (mago homolog, exon junction complex subunit)
Type: protein-coding
Summary: Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mR... |
Does Knockout of CENPN in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | CENPN | cell proliferation | Mammary Gland Tumor Cell Line | Gene: CENPN (centromere protein N)
Type: protein-coding
Summary: The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of thi... |
Does Knockout of ISCA1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | ISCA1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ISCA1 (iron-sulfur cluster assembly 1)
Type: protein-coding
Summary: ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008].
... |
Does Knockout of TOP1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | TOP1 | cell proliferation | Endometrial Cancer Cell Line | Gene: TOP1 (DNA topoisomerase I)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass... |
Does Knockout of E2F5 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | E2F5 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: E2F5 (E2F transcription factor 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming... |
Does Knockout of RCBTB2 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | RCBTB2 | cell proliferation | Medulloblastoma Cell Line | Gene: RCBTB2 (RCC1 and BTB domain containing protein 2)
Type: protein-coding
Summary: This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is obs... |
Does Knockout of NMD3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | NMD3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: NMD3 (NMD3 ribosome export adaptor)
Type: protein-coding
Summary: Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Sev... |
Does Knockout of HNRNPU in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | HNRNPU | cell proliferation | Colonic Cancer Cell Line | Gene: HNRNPU (heterogeneous nuclear ribonucleoprotein U)
Type: protein-coding
Summary: This gene encodes a member of a family of proteins that bind nucleic acids and function in the formation of ribonucleoprotein complexes in the nucleus with heterogeneous nuclear RNA (hnRNA). The encoded protein has af... |
Does Knockout of MIR548AE2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | MIR548AE2 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: MIR548AE2 (microRNA 548ae-2)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polym... |
Does Knockout of CSF2 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | CSF2 | cell proliferation | Cancer Cell Line | Gene: CSF2 (colony stimulating factor 2)
Type: protein-coding
Summary: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been lo... |
Does Knockout of SLC16A10 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | SLC16A10 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: SLC16A10 (solute carrier family 16 member 10)
Type: protein-coding
Summary: SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004].
Gene Ontolo... |
Does Knockout of MRGPRX4 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | MRGPRX4 | cell proliferation | Endometrial Cancer Cell Line | Gene: MRGPRX4 (MAS related GPR family member X4)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within chemosensory behavior and hematopoietic progenitor cell... |
Does Knockout of BCAM in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | BCAM | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: BCAM (basal cell adhesion molecule (Lutheran blood group))
Type: protein-coding
Summary: This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobu... |
Does Knockout of PCK1 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | PCK1 | cell proliferation | Glioblastoma Cell Line | Gene: PCK1 (phosphoenolpyruvate carboxykinase 1)
Type: protein-coding
Summary: This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon ... |
Does Knockout of CLK4 in Lung Cancer Cell Line causally result in response to virus? | 1 | 1,433 | Knockout | CLK4 | response to virus | Lung Cancer Cell Line | Gene: CLK4 (CDC like kinase 4)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the format... |
Does Knockout of UROD in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | UROD | cell proliferation | Ewing's Sarcoma Cell Line | Gene: UROD (uroporphyrinogen decarboxylase)
Type: protein-coding
Summary: This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and ... |
Does Knockout of SOAT1 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | SOAT1 | response to chemicals | Monocytic Leukemia Cell Line | Gene: SOAT1 (sterol O-acyltransferase 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-... |
Does Knockout of UGT2B11 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | UGT2B11 | cell proliferation | Medulloblastoma Cell Line | Gene: UGT2B11 (UDP glucuronosyltransferase family 2 member B11)
Type: protein-coding
Summary: Enables glucuronosyltransferase activity. Involved in estrogen metabolic process and xenobiotic glucuronidation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of ... |
Does Knockout of DNAAF1 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | DNAAF1 | cell proliferation | Breast Cancer Cell Line | Gene: DNAAF1 (dynein axonemal assembly factor 1)
Type: protein-coding
Summary: The protein encoded by this gene is cilium-specific and is required for the stability of the ciliary architecture. It is involved in the regulation of microtubule-based cilia and actin-based brush border microvilli. Mutations... |
Does Knockout of IL12RB2 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | IL12RB2 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: IL12RB2 (interleukin 12 receptor subunit beta 2)
Type: protein-coding
Summary: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high... |
Does Knockout of TUBGCP4 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 519 | Knockout | TUBGCP4 | cell proliferation | Glioblastoma Cell Line | Gene: TUBGCP4 (tubulin gamma complex component 4)
Type: protein-coding
Summary: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure ana... |
Does Knockout of RASSF1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | RASSF1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: RASSF1 (Ras association domain family member 1)
Type: protein-coding
Summary: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of... |
Does Knockout of VRK1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | VRK1 | cell proliferation | Endometrial Cancer Cell Line | Gene: VRK1 (VRK serine/threonine kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in te... |
Does Knockout of KRT34 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | KRT34 | cell proliferation | Glioblastoma Cell Line | Gene: KRT34 (keratin 34)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chro... |
Does Knockout of MRPS30 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | MRPS30 | cell proliferation | Endometrial Cancer Cell Line | Gene: MRPS30 (mitochondrial ribosomal protein S30)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of SEC22A in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | SEC22A | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: SEC22A (SEC22 homolog A, vesicle trafficking protein)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provid... |
Does Knockout of SCAMP4 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | SCAMP4 | cell proliferation | T-lymphoma cell line | Gene: SCAMP4 (secretory carrier membrane protein 4)
Type: protein-coding
Summary: Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeat... |
Does Knockout of RPS2 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | RPS2 | cell proliferation | Colonic Cancer Cell Line | Gene: RPS2 (ribosomal protein S2)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ... |
Does Knockout of MCAM in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | MCAM | response to virus | Huh-7 Cell | Gene: MCAM (melanoma cell adhesion molecule)
Type: protein-coding
Summary: Involved in glomerular filtration and vascular wound healing. Acts upstream of or within angiogenesis. Located in external side of plasma membrane. Biomarker of chronic obstructive pulmonary disease and uveal melanoma. [provided ... |
Does Knockout of RFC5 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | RFC5 | cell proliferation | Colonic Cancer Cell Line | Gene: RFC5 (replication factor C subunit 5)
Type: protein-coding
Summary: This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal reg... |
Does Knockout of ALDH8A1 in Cancer Cell Line causally result in cell proliferation? | 0 | 193 | Knockout | ALDH8A1 | cell proliferation | Cancer Cell Line | Gene: ALDH8A1 (aldehyde dehydrogenase 8 family member A1)
Type: protein-coding
Summary: This gene encodes a member of the aldehyde dehydrogenase family of proteins. The encoded protein has been implicated in the synthesis of 9-cis-retinoic acid and in the breakdown of the amino acid tryptophan. This enz... |
Does Knockout of GTSE1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | GTSE1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: GTSE1 (G2 and S-phase expressed 1)
Type: protein-coding
Summary: The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus an... |
Does Knockout of PMF1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | PMF1 | cell proliferation | Endometrial Cancer Cell Line | Gene: PMF1 (polyamine modulated factor 1)
Type: protein-coding
Summary: Enables leucine zipper domain binding activity and transcription coactivator activity. Involved in chromosome segregation. Located in Golgi apparatus; kinetochore; and nucleoplasm. Part of MIS12/MIND type complex. Implicated in blad... |
Does Knockout of COL28A1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | COL28A1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: COL28A1 (collagen type XXVIII alpha 1 chain)
Type: protein-coding
Summary: COL28A1 belongs to a class of collagens containing von Willebrand factor (VWF; MIM 613160) type A (VWFA) domains (Veit et al., 2006 [PubMed 16330543]).[supplied by OMIM, Nov 2010].
Gene Ontology: MF: extracellular ... |
Does Knockout of PDE8A in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | PDE8A | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PDE8A (phosphodiesterase 8A)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to ex... |
Does Knockout of FAM86B1 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | FAM86B1 | cell proliferation | Prostate Cancer Cell Line | Gene: FAM86B1 (family with sequence similarity 86 member B1 (gene/pseudogene))
Type: protein-coding
Summary: Predicted to enable methyltransferase activity. Predicted to be involved in methylation. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: methyltransferase activit... |
Does Inhibition of RFX1 in Mammary Epithelial Cell Line causally result in cell proliferation? | 0 | 2,248 | Inhibition | RFX1 | cell proliferation | Mammary Epithelial Cell Line | Gene: RFX1 (regulatory factor X1)
Type: protein-coding
Summary: This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-ter... |
Does Knockout of SPTY2D1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | SPTY2D1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: SPTY2D1 (SPT2 chromatin protein domain containing 1)
Type: protein-coding
Summary: Enables DNA binding activity and histone binding activity. Involved in nucleosome organization; regulation of chromatin assembly; and regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm.... |
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