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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of SNRPG in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
SNRPG
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: SNRPG (small nuclear ribonucleoprotein polypeptide G)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: 7-methylguanosine cap hypermethylation, RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, spliceosomal complex assembly, spliceosomal snRNP assembly; MF: RNA binding, protein binding; CC: P granule, SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type prespliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, precatalytic spliceosome, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Disease, Gene expression (Transcription), Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Homo sapiens (human), Viral Infection Pathways, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62308
Entrez ID: 6637
|
Does Knockout of STRA8 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 1,311
|
Knockout
|
STRA8
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: STRA8 (stimulated by retinoic acid 8)
Type: protein-coding
Summary: This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: DNA replication, activation of meiosis, cell differentiation, cellular response to retinoic acid, meiotic cell cycle, oogenesis, regulation of transcription by RNA polymerase II, spermatogenesis; MF: protein binding, protein dimerization activity; CC: cytoplasm, nucleus
Pathways: Male infertility
UniProt: Q7Z7C7
Entrez ID: 346673
|
Does Knockout of EIF2S2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
EIF2S2
|
cell proliferation
|
Cancer Cell Line
|
Gene: EIF2S2 (eukaryotic translation initiation factor 2 subunit beta)
Type: protein-coding
Summary: Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: cytoplasmic translational initiation, formation of translation preinitiation complex, in utero embryonic development, male germ cell proliferation, male gonad development, translation, translational initiation; MF: RNA binding, mRNA binding, metal ion binding, protein binding, translation factor activity, RNA binding, translation initiation factor activity, translation initiation factor binding, zinc ion binding; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2 complex, nucleus, synapse
Pathways: ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Brain-derived neurotrophic factor (BDNF) signaling pathway, Cap-dependent Translation Initiation, Cellular response to mitochondrial stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Eukaryotic Translation Initiation, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Immune System, Interferon Signaling, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, PERK regulates gene expression, PKR-mediated signaling, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Response of EIF2AK1 (HRI) to heme deficiency, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, Transport of small molecules, Unfolded Protein Response (UPR), double stranded rna induced gene expression, eukaryotic protein translation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell, regulation of eif2, skeletal muscle hypertrophy is regulated via akt-mtor pathway
UniProt: P20042
Entrez ID: 8894
|
Does Knockout of DCAF4 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
DCAF4
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: DCAF4 (DDB1 and CUL4 associated factor 4)
Type: protein-coding
Summary: This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009].
Gene Ontology: CC: Cul4-RING E3 ubiquitin ligase complex, nucleoplasm
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q8WV16
Entrez ID: 26094
|
Does Knockout of CSTF1 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
CSTF1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: CSTF1 (cleavage stimulation factor subunit 1)
Type: protein-coding
Summary: This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mRNA 3'-end processing, mRNA processing; MF: RNA binding, protein binding; CC: mRNA cleavage stimulating factor complex, nucleoplasm, nucleus
Pathways: BARD1 signaling events, Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human), polyadenylation of mrna
UniProt: Q05048
Entrez ID: 1477
|
Does Knockout of SPECC1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
SPECC1
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: SPECC1 (sperm antigen with calponin homology and coiled-coil domains 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta gene (PDGFRB) may be a cause of juvenile myelomonocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: actin cytoskeleton organization, associative learning, blastocyst development; CC: apical part of cell, cytoplasm, cytosol, fibrillar center, filamentous actin, membrane, microtubule organizing center, nucleoplasm, nucleus
Pathways:
UniProt: Q5M775
Entrez ID: 92521
|
Does Knockout of MRPL32 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
MRPL32
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: MRPL32 (mitochondrial ribosomal protein L32)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial matrix, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9BYC8
Entrez ID: 64983
|
Does Knockout of LGALS7 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
LGALS7
|
cell proliferation
|
Cancer Cell Line
|
Gene: LGALS7 (galectin 7)
Type: protein-coding
Summary: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways: Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
UniProt: P47929
Entrez ID: 3963
|
Does Knockout of FKSG49 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
FKSG49
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: FKSG49 (hepatocellular carcinoma-associated antigen HCA25b)
Type: other
Summary: hepatocellular carcinoma-associated antigen HCA25b
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 400949
|
Does Knockout of ETV4 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
ETV4
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ETV4 (ETS variant transcription factor 4)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of keratinocyte differentiation and positive regulation of transcription by RNA polymerase II. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, positive regulation of keratinocyte differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, chromosome, nucleolus, nucleoplasm, nucleus
Pathways: Development of ureteric collection system, Genes controlling nephrogenesis, LKB1 signaling events, Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: P43268
Entrez ID: 2118
|
Does Knockout of ARF3 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
ARF3
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ARF3 (ARF GTPase 3)
Type: protein-coding
Summary: ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 6 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2,and ARF3), class II (ARF4 and ARF5) and class III (ARF6) and members of each class share a common gene organization. [provided by RefSeq, Oct 2022].
Gene Ontology: BP: intracellular protein transport, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: GTP binding, GTPase activity, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, extracellular exosome, perinuclear region of cytoplasm, plasma membrane
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Endocytosis - Homo sapiens (human), Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism, Metabolism of lipids, Metabolism of proteins, PI Metabolism, Phospholipid metabolism, Post-translational protein modification, Synthesis of PIPs at the Golgi membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P61204
Entrez ID: 377
|
Does Knockout of TTC4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
TTC4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: TTC4 (tetratricopeptide repeat domain 4)
Type: protein-coding
Summary: This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: defense response to virus, immune system process, innate immune response, protein folding; MF: Hsp70 protein binding, Hsp90 protein binding, protein binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways:
UniProt: O95801
Entrez ID: 7268
|
Does Knockout of CREG1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
CREG1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: CREG1 (cellular repressor of E1A stimulated genes 1)
Type: protein-coding
Summary: The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: autophagy, endocytosis, lysosomal lumen acidification, lysosome organization, negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; CC: azurophil granule lumen, cytoplasm, endomembrane system, endosome, extracellular exosome, extracellular region, extracellular space, lysosome, transcription regulator complex
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, Senescence and Autophagy in Cancer
UniProt: O75629
Entrez ID: 8804
|
Does Knockout of ATF4 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
ATF4
|
cell proliferation
|
Melanoma Cell Line
|
Gene: ATF4 (activating transcription factor 4)
Type: protein-coding
Summary: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011].
Gene Ontology: BP: GDF15-GFRAL signaling pathway, HRI-mediated signaling, L-asparagine metabolic process, PERK-mediated unfolded protein response, bone mineralization, cellular response to UV, cellular response to amino acid starvation, cellular response to glucose starvation, cellular response to hypoxia, cellular response to leucine starvation, cellular response to oxidative stress, circadian regulation of gene expression, circadian rhythm, embryonic hemopoiesis, endoplasmic reticulum unfolded protein response, gamma-aminobutyric acid signaling pathway, gluconeogenesis, integrated stress response signaling, intracellular calcium ion homeostasis, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, lens fiber cell morphogenesis, mRNA transcription by RNA polymerase II, mitochondrial respirasome assembly, negative regulation of cold-induced thermogenesis, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of potassium ion transport, negative regulation of transcription by RNA polymerase II, negative regulation of translational initiation in response to stress, neuron differentiation, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of biomineral tissue development, positive regulation of gene expression, positive regulation of neuron apoptotic process, positive regulation of sodium-dependent phosphate transport, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell apoptotic process, positive regulation of vascular endothelial growth factor production, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of osteoblast differentiation, regulation of synaptic plasticity, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to manganese-induced endoplasmic reticulum stress, response to nutrient levels, response to toxic substance, rhythmic process, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, cAMP response element binding protein binding, general transcription initiation factor binding, identical protein binding, leucine zipper domain binding, promoter-specific chromatin binding, protein binding, protein heterodimerization activity, protein kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: ATF1-ATF4 transcription factor complex, ATF4-CREB1 transcription factor complex, CHOP-ATF4 complex, Lewy body core, RNA polymerase II transcription regulator complex, centrosome, chromatin, cytoplasm, cytoskeleton, cytosol, dendrite membrane, membrane, mitochondrion, neuron projection, nuclear periphery, nuclear speck, nucleoplasm, nucleus, plasma membrane, protein-containing complex, transcription regulator complex
Pathways: ATF4 activates genes in response to endoplasmic reticulum stress, ATF6 (ATF6-alpha) activates chaperone genes, ATF6 (ATF6-alpha) activates chaperones, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Alcoholism - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Alzheimer disease - Homo sapiens (human), Amphetamine addiction - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis - Homo sapiens (human), Cellular response to chemical stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Cholinergic synapse - Homo sapiens (human), Cocaine addiction - Homo sapiens (human), Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human), Dopaminergic synapse - Homo sapiens (human), Estrogen signaling pathway - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Glucagon signaling pathway - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Insulin secretion - Homo sapiens (human), Joubert Syndrome, KEAP1-NFE2L2 pathway, Lipid and atherosclerosis - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), Longevity regulating pathway - Homo sapiens (human), MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mitophagy - animal - Homo sapiens (human), Myometrial relaxation and contraction pathways, NFE2L2 regulating ER-stress associated genes, NFE2L2 regulating anti-oxidant/detoxification enzymes, Neurotrophin signaling pathway - Homo sapiens (human), Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Nuclear events mediated by NFE2L2, PERK regulates gene expression, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Photodynamic therapy-induced unfolded protein response, Prion disease - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Protein processing in endoplasmic reticulum - Homo sapiens (human), Relaxin signaling pathway - Homo sapiens (human), Renin-angiotensin-aldosterone system (RAAS), Response of EIF2AK1 (HRI) to heme deficiency, Response of EIF2AK4 (GCN2) to amino acid deficiency, TNF signaling pathway - Homo sapiens (human), Thyroid hormone synthesis - Homo sapiens (human), Unfolded Protein Response (UPR), Unfolded protein response, VEGFA-VEGFR2 Signaling Pathway, Validated transcriptional targets of AP1 family members Fra1 and Fra2, Viral carcinogenesis - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P18848
Entrez ID: 468
|
Does Activation of PCYOX1L in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
PCYOX1L
|
response to virus
|
Hepatoma Cell Line
|
Gene: PCYOX1L (prenylcysteine oxidase 1 like)
Type: protein-coding
Summary: Predicted to enable prenylcysteine oxidase activity. Predicted to be involved in prenylated protein catabolic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: neutrophil-mediated killing of bacterium, prenylated protein catabolic process, prenylcysteine catabolic process; MF: oxidoreductase activity, oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor, prenylcysteine oxidase activity; CC: extracellular region, membrane, platelet alpha granule lumen
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q8NBM8
Entrez ID: 78991
|
Does Knockout of TREM2 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
TREM2
|
cell proliferation
|
T-lymphoma cell line
|
Gene: TREM2 (triggering receptor expressed on myeloid cells 2)
Type: protein-coding
Summary: This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: CXCL12-activated CXCR4 signaling pathway, T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell, amyloid-beta clearance, amyloid-beta clearance by cellular catabolic process, apoptotic cell clearance, astrocyte activation, cell development, cell surface receptor signaling pathway, cellular response to amyloid-beta, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to lipid, cellular response to lipoprotein particle stimulus, cellular response to lipoteichoic acid, cellular response to oxidised low-density lipoprotein particle stimulus, cellular response to peptidoglycan, complement-mediated synapse pruning, defense response to Gram-negative bacterium, defense response to bacterium, dendritic cell differentiation, dendritic spine maintenance, detection of lipopolysaccharide, detection of lipoteichoic acid, detection of peptidoglycan, excitatory synapse pruning, humoral immune response, immune response, import into cell, lipid homeostasis, memory, microglial cell activation, microglial cell activation involved in immune response, microglial cell proliferation, negative regulation of NLRP3 inflammasome complex assembly, negative regulation of amyloid fibril formation, negative regulation of apoptotic process, negative regulation of astrocyte activation, negative regulation of autophagic cell death, negative regulation of autophagy, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cell activation, negative regulation of cholesterol storage, negative regulation of cytokine production involved in inflammatory response, negative regulation of fat cell proliferation, negative regulation of glial cell apoptotic process, negative regulation of inflammatory response to antigenic stimulus, negative regulation of interleukin-1 beta production, negative regulation of macrophage colony-stimulating factor signaling pathway, negative regulation of neuroinflammatory response, negative regulation of p38MAPK cascade, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of toll-like receptor 2 signaling pathway, negative regulation of toll-like receptor 4 signaling pathway, negative regulation of triglyceride storage, negative regulation of tumor necrosis factor production, neuroinflammatory response, osteoclast differentiation, phagocytosis, phagocytosis, engulfment, phagocytosis, recognition, positive regulation of ATP biosynthetic process, positive regulation of C-C chemokine receptor CCR7 signaling pathway, positive regulation of CAMKK-AMPK signaling cascade, positive regulation of CD40 signaling pathway, positive regulation of ERK1 and ERK2 cascade, positive regulation of TOR signaling, positive regulation of amyloid-beta clearance, positive regulation of antigen processing and presentation of peptide antigen via MHC class II, positive regulation of calcium-mediated signaling, positive regulation of chemotaxis, positive regulation of cholesterol efflux, positive regulation of complement activation, classical pathway, positive regulation of engulfment of apoptotic cell, positive regulation of establishment of protein localization, positive regulation of gene expression, positive regulation of high-density lipoprotein particle clearance, positive regulation of interleukin-10 production, positive regulation of intracellular signal transduction, positive regulation of low-density lipoprotein particle clearance, positive regulation of macrophage fusion, positive regulation of microglial cell activation, positive regulation of microglial cell migration, positive regulation of neuroinflammatory response, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of osteoclast differentiation, positive regulation of phagocytosis, positive regulation of phagocytosis, engulfment, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of potassium ion transport, positive regulation of proteasomal protein catabolic process, positive regulation of protein localization to plasma membrane, positive regulation of protein secretion, positive regulation of synapse pruning, pyroptotic inflammatory response, regulation of TOR signaling, regulation of biological quality, regulation of cytokine production involved in inflammatory response, regulation of gene expression, regulation of hippocampal neuron apoptotic process, regulation of innate immune response, regulation of interleukin-6 production, regulation of lipid metabolic process, regulation of macrophage inflammatory protein 1 alpha production, regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, regulation of plasma membrane bounded cell projection organization, regulation of primary metabolic process, regulation of resting membrane potential, regulation of toll-like receptor 6 signaling pathway, respiratory burst after phagocytosis, response to axon injury, response to ischemia, semaphorin-plexin signaling pathway, signal transduction, social behavior; MF: amyloid-beta binding, apolipoprotein A-I binding, apolipoprotein binding, beta-catenin binding, carbohydrate derivative binding, high-density lipoprotein particle binding, kinase activator activity, lipid binding, lipopolysaccharide binding, lipoprotein particle binding, lipoteichoic acid binding, low-density lipoprotein particle binding, peptidoglycan binding, phosphatidylethanolamine binding, phosphatidylserine binding, phospholipid binding, protein binding, protein tyrosine kinase binding, protein-containing complex binding, scaffold protein binding, semaphorin receptor activity, semaphorin receptor binding, signaling receptor activity, sulfatide binding, transmembrane signaling receptor activity, very-low-density lipoprotein particle binding; CC: extracellular region, membrane, plasma membrane, plasma membrane raft, semaphorin receptor complex
Pathways: Adaptive Immune System, Axon guidance, DAP12 interactions, DAP12 signaling, Developmental Biology, Immune System, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, Innate Immune System, Microglia Pathogen Phagocytosis Pathway, Nervous system development, Osteoclast differentiation - Homo sapiens (human), Other semaphorin interactions, RANKL, Semaphorin interactions
UniProt: Q9NZC2
Entrez ID: 54209
|
Does Knockout of RPL10A in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
RPL10A
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPL10A (ribosomal protein L10a)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, response to ethanol, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, focal adhesion, large ribosomal subunit, membrane, nucleus, postsynaptic density, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, VEGFA-VEGFR2 Signaling Pathway, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62906
Entrez ID: 4736
|
Does Knockout of ALG12 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
ALG12
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: ALG12 (ALG12 alpha-1,6-mannosyltransferase)
Type: protein-coding
Summary: This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, protein N-linked glycosylation, protein folding, protein glycosylation; MF: alpha-1,6-mannosyltransferase activity, dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity, glycosyltransferase activity, mannosyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, lumenal side of endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective ALG12 causes CDG-1g, Disease, Diseases associated with N-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), Post-translational protein modification, Various types of N-glycan biosynthesis - Homo sapiens (human)
UniProt: Q9BV10
Entrez ID: 79087
|
Does Knockout of DHX57 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
DHX57
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: DHX57 (DExH-box helicase 57)
Type: protein-coding
Summary: Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA polymerase binding, helicase activity, hydrolase activity, metal ion binding, nucleic acid binding, nucleotide binding, protein binding, zinc ion binding
Pathways:
UniProt: Q6P158
Entrez ID: 90957
|
Does Knockout of CRYM in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
CRYM
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: CRYM (crystallin mu)
Type: protein-coding
Summary: Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: lysine catabolic process, negative regulation of transcription by RNA polymerase II, sensory perception of sound, thyroid hormone metabolic process, thyroid hormone transport; MF: NADP binding, delta1-piperideine-2-carboxylate reductase activity, hormone binding, oxidoreductase activity, protein binding, protein homodimerization activity, thiomorpholine-carboxylate dehydrogenase activity, thyroid hormone binding, transcription corepressor activity; CC: cytoplasm, cytosol, extracellular exosome, mitochondrion, nucleus, peroxisomal matrix
Pathways: Lysine catabolism, Metabolism, Metabolism of amino acids and derivatives, lysine degradation II (pipecolate pathway)
UniProt: Q14894
Entrez ID: 1428
|
Does Knockout of DACH2 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
DACH2
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: DACH2 (dachshund family transcription factor 2)
Type: protein-coding
Summary: This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008].
Gene Ontology: BP: development of primary female sexual characteristics, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding; CC: nucleus, transcription regulator complex
Pathways:
UniProt: Q96NX9
Entrez ID: 117154
|
Does Knockout of NUP37 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
NUP37
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: NUP37 (nucleoporin 37)
Type: protein-coding
Summary: Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: cell division, chromosome segregation, mRNA transport, nucleocytoplasmic transport, protein transport; CC: chromosome, chromosome, centromeric region, cytosol, kinetochore, nuclear envelope, nuclear pore, nuclear pore outer ring, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, EML4 and NUDC in mitotic spindle formation, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Mitotic Spindle Checkpoint, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Resolution of Sister Chromatid Cohesion, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q8NFH4
Entrez ID: 79023
|
Does Knockout of MRPS18A in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
MRPS18A
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MRPS18A (mitochondrial ribosomal protein S18A)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010].
Gene Ontology: BP: mitochondrial translation, translation; MF: small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9NVS2
Entrez ID: 55168
|
Does Knockout of LCOR in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
LCOR
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: LCOR (ligand dependent nuclear receptor corepressor)
Type: protein-coding
Summary: LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cellular response to estradiol stimulus, negative regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, histone deacetylase binding, histone methyltransferase binding, nuclear estrogen receptor binding, protein binding, transcription corepressor activity, transcription corepressor binding, ubiquitin-specific protease binding; CC: nucleoplasm, nucleus
Pathways: Validated nuclear estrogen receptor alpha network
UniProt: Q96JN0
Entrez ID: 84458
|
Does Knockout of CNIH1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
CNIH1
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: CNIH1 (cornichon family member 1)
Type: protein-coding
Summary: Predicted to be involved in immune response and signal transduction. Predicted to be located in ER to Golgi transport vesicle membrane; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: immune response, signal transduction, vesicle-mediated transport; MF: protein binding, signaling receptor binding; CC: ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane
Pathways: Asparagine N-linked glycosylation, COPII-mediated vesicle transport, Cargo concentration in the ER, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O95406
Entrez ID: 10175
|
Does Knockout of NADSYN1 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
NADSYN1
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: NADSYN1 (NAD synthetase 1)
Type: protein-coding
Summary: Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004].
Gene Ontology: BP: 'de novo' NAD+ biosynthetic process from L-tryptophan, NAD+ biosynthetic process, NAD+ biosynthetic process via the salvage pathway; MF: ATP binding, NAD+ synthase (glutamine-hydrolyzing) activity, glutaminase activity, ligase activity, nucleotide binding, protein binding; CC: cytoplasm, cytosol
Pathways: 2-Hydroxyglutric Aciduria (D And L Form), 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency, Glutamate Metabolism, Homocarnosinosis, Hyperinsulinism-Hyperammonemia Syndrome, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, NAD <i>de novo</i> biosynthesis, NAD Biosynthesis II (from tryptophan), NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde, NAD+ biosynthetic pathways, Nicotinate and Nicotinamide Metabolism, Nicotinate and nicotinamide metabolism - Homo sapiens (human), Nicotinate metabolism, Succinic semialdehyde dehydrogenase deficiency, superpathway of tryptophan utilization
UniProt: Q6IA69
Entrez ID: 55191
|
Does Knockout of OVCH1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
OVCH1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: OVCH1 (ovochymase 1)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: fertilization, proteolysis; MF: hydrolase activity, metal ion binding, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity
Pathways:
UniProt:
Entrez ID: 341350
|
Does Knockout of TECPR2 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
TECPR2
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: TECPR2 (tectonin beta-propeller repeat containing 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy, as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR), which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: autophagy, protein exit from endoplasmic reticulum
Pathways:
UniProt: O15040
Entrez ID: 9895
|
Does Knockout of ZNF235 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
ZNF235
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: ZNF235 (zinc finger protein 235)
Type: protein-coding
Summary: This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein is a member of the Kruppel family of zinc finger proteins, and contains Kruppel-associated box (KRAB) A and B domains and 15 tandemly arrayed C2H2-type zinc fingers. It is an ortholog of the mouse Zfp93 protein. This gene is located in a cluster of zinc finger genes on 19q13.2. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, metal ion binding, sequence-specific DNA binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q14590
Entrez ID: 9310
|
Does Knockout of BTNL8 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
BTNL8
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: BTNL8 (butyrophilin like 8)
Type: protein-coding
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: T cell receptor signaling pathway, adaptive immune response, immune system process, regulation of cytokine production; MF: protein binding, signaling receptor binding; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q6UX41
Entrez ID: 79908
|
Does Knockout of MED20 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
MED20
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: MED20 (mediator complex subunit 20)
Type: protein-coding
Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: DNA-templated transcription, RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II, skeletal muscle cell differentiation, transcription by RNA polymerase II; MF: DNA-directed RNA polymerase activity, protein binding, transcription coactivator activity, transcription coregulator activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, protein-containing complex
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9H944
Entrez ID: 9477
|
Does Knockout of SLC6A7 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
SLC6A7
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: SLC6A7 (solute carrier family 6 member 7)
Type: protein-coding
Summary: This gene is a member of the gamma-aminobutyric acid (GABA) neurotransmitter gene family and encodes a high-affinity mammalian brain L-proline transporter protein. This transporter protein differs from other sodium-dependent plasma membrane carriers by its pharmacological specificity, kinetic properties, and ionic requirements. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: amino acid transport, glycine import across plasma membrane, neurotransmitter transport, proline transmembrane transport, proline transport, protein catabolic process, sodium ion transmembrane transport; MF: L-proline transmembrane transporter activity, proline:sodium symporter activity, symporter activity, transmembrane transporter activity; CC: membrane, plasma membrane, synapse, synaptic membrane
Pathways: Creatine metabolism, Metabolism, Metabolism of amino acids and derivatives, NRF2 pathway, Nuclear Receptors Meta-Pathway, SLC-mediated transmembrane transport, SLC-mediated transport of neurotransmitters, Synaptic vesicle cycle - Homo sapiens (human), Transport of small molecules
UniProt: Q99884
Entrez ID: 6534
|
Does Knockout of TCF20 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
TCF20
|
cell proliferation
|
Melanoma Cell Line
|
Gene: TCF20 (transcription factor 20)
Type: protein-coding
Summary: This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, RNA binding, metal ion binding, protein binding, zinc ion binding; CC: nuclear body, nucleoplasm, nucleus
Pathways: Matrix Metalloproteinases
UniProt: Q9UGU0
Entrez ID: 6942
|
Does Knockout of UCHL5 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
UCHL5
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: UCHL5 (ubiquitin C-terminal hydrolase L5)
Type: protein-coding
Summary: Enables endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, chromatin remodeling, forebrain morphogenesis, lateral ventricle development, midbrain development, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of DNA repair, positive regulation of DNA-templated transcription, positive regulation of smoothened signaling pathway, positive regulation of telomere maintenance in response to DNA damage, protein deubiquitination, proteolysis, regulation of DNA repair, regulation of DNA replication, regulation of DNA strand elongation, regulation of cell cycle, regulation of chromosome organization, regulation of embryonic development, regulation of proteasomal protein catabolic process, telomere maintenance, ubiquitin-dependent protein catabolic process; MF: RNA binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, endopeptidase inhibitor activity, hydrolase activity, peptidase activity, proteasome binding, protein binding; CC: Ino80 complex, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, proteasome complex
Pathways: TGF-beta Signaling Pathway
UniProt: Q9Y5K5
Entrez ID: 51377
|
Does Knockout of OR51D1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
OR51D1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: OR51D1 (olfactory receptor family 51 subfamily D member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to lipid, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction, system process; MF: G protein-coupled receptor activity, olfactory receptor activity, signaling receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGF3
Entrez ID: 390038
|
Does Knockout of ZNF223 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
ZNF223
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: ZNF223 (zinc finger protein 223)
Type: protein-coding
Summary: This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9UK11
Entrez ID: 7766
|
Does Knockout of ADAM9 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
ADAM9
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ADAM9 (ADAM metallopeptidase domain 9)
Type: protein-coding
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: amyloid precursor protein catabolic process, cell adhesion, cell adhesion mediated by integrin, cell migration, cell-cell adhesion mediated by integrin, cell-matrix adhesion, cellular response to lipopolysaccharide, integrin-mediated signaling pathway, keratinocyte differentiation, membrane protein ectodomain proteolysis, membrane protein intracellular domain proteolysis, monocyte activation, positive regulation of MAPK cascade, positive regulation of cell adhesion mediated by integrin, positive regulation of cell migration, positive regulation of keratinocyte migration, positive regulation of macrophage fusion, positive regulation of membrane protein ectodomain proteolysis, positive regulation of protein secretion, protein processing, proteolysis, response to calcium ion, response to glucocorticoid, response to hydrogen peroxide, response to manganese ion, response to tumor necrosis factor, transforming growth factor beta receptor signaling pathway; MF: SH3 domain binding, collagen binding, hydrolase activity, integrin binding, laminin binding, metal ion binding, metalloendopeptidase activity, metalloendopeptidase activity involved in amyloid precursor protein catabolic process, metallopeptidase activity, peptidase activity, protein binding, protein kinase C binding; CC: cell surface, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, focal adhesion, membrane, plasma membrane
Pathways: Collagen degradation, Copper homeostasis, Degradation of the extracellular matrix, EGFR1, Extracellular matrix organization, TCR, VEGFA-VEGFR2 Signaling Pathway
UniProt: Q13443
Entrez ID: 8754
|
Does Knockout of PRB4 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
PRB4
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: PRB4 (proline rich protein BstNI subfamily 4)
Type: protein-coding
Summary: This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the 'Small' allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015].
Gene Ontology: CC: extracellular region
Pathways:
UniProt: E7EXA8, E9PAL0
Entrez ID: 5545
|
Does Knockout of TMEM72 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
TMEM72
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: TMEM72 (transmembrane protein 72)
Type: protein-coding
Summary: This gene encodes a transmembrane protein which may be expressed specifically in the kidney. [provided by RefSeq, Sep 2016].
Gene Ontology: CC: cytoplasm, early endosome membrane, membrane, nucleus, plasma membrane
Pathways:
UniProt: A0PK05
Entrez ID: 643236
|
Does Knockout of EIF4A1 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
EIF4A1
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: EIF4A1 (eukaryotic translation initiation factor 4A1)
Type: protein-coding
Summary: Enables double-stranded RNA binding activity. Predicted to be involved in cytoplasmic translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoplasmic translational initiation, positive regulation of transcription by RNA polymerase II, translation, translational initiation; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA cap binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, cytoplasmic stress granule, cytosol, eukaryotic translation initiation factor 4F complex, extracellular exosome, membrane, nuclear stress granule, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Cap-dependent Translation Initiation, Cytokine Signaling in Immune system, Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Developmental Biology, Eukaryotic Translation Initiation, Fragile X Syndrome, GTP hydrolysis and joining of the 60S ribosomal subunit, ISG15 antiviral mechanism, Immune System, Interferon Signaling, Interferon type I signaling pathways, L13a-mediated translational silencing of Ceruloplasmin expression, M-decay: degradation of maternal mRNAs by maternally stored factors, Maternal to zygotic transition (MZT), Metabolism of RNA, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation inhibitors in chronically activated PDGFRA cells, Translation initiation complex formation, Validated targets of C-MYC transcriptional activation, Z-decay: degradation of maternal mRNAs by zygotically expressed factors, eukaryotic protein translation, internal ribosome entry pathway, mTOR signaling pathway, mtor signaling pathway, regulation of eif-4e and p70s6 kinase, skeletal muscle hypertrophy is regulated via akt-mtor pathway
UniProt: P60842
Entrez ID: 1973
|
Does Knockout of EEF2KMT in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
EEF2KMT
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase)
Type: protein-coding
Summary: Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: methylation, peptidyl-lysine trimethylation; MF: methyltransferase activity, protein binding, protein-lysine N-methyltransferase activity, transferase activity; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Protein methylation
UniProt: Q96G04
Entrez ID: 196483
|
Does Knockout of NFYC in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
NFYC
|
cell proliferation
|
Bladder Carcinoma
|
Gene: NFYC (nuclear transcription factor Y subunit gamma)
Type: protein-coding
Summary: This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
Gene Ontology: BP: positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, protein folding, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, protein heterodimerization activity, transcription cis-regulatory region binding; CC: CCAAT-binding factor complex, RNA polymerase II transcription regulator complex, chromatin, nucleoplasm, nucleus, protein-DNA complex, transcription regulator complex
Pathways: Antigen processing and presentation - Homo sapiens (human), Direct p53 effectors, TGF_beta_Receptor, Tuberculosis - Homo sapiens (human), Validated targets of C-MYC transcriptional repression, overview of telomerase rna component gene hterc transcriptional regulation
UniProt: Q13952
Entrez ID: 4802
|
Does Knockout of ISCU in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
ISCU
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: ISCU (iron-sulfur cluster assembly enzyme)
Type: protein-coding
Summary: This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, and oxidative stress response. Alternative splicing results in transcript variants encoding different protein isoforms that localize either to the cytosol or to the mitochondrion. Mutations in this gene have been found in patients with hereditary myopathy with lactic acidosis. A disease-associated mutation in an intron may activate a cryptic splice site, resulting in the production of a splice variant encoding a putatively non-functional protein. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: [2Fe-2S] cluster assembly, [4Fe-4S] cluster assembly, intracellular iron ion homeostasis, iron-sulfur cluster assembly, negative regulation of iron ion import across plasma membrane, positive regulation of mitochondrial electron transport, NADH to ubiquinone; MF: 2 iron, 2 sulfur cluster binding, ferrous iron binding, iron ion binding, iron-sulfur cluster binding, iron-sulfur cluster chaperone activity, metal ion binding, molecular adaptor activity, protein binding, protein homodimerization activity, zinc ion binding; CC: cytoplasm, cytosol, iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrial matrix, mitochondrion, nucleus
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Complex III assembly, Maturation of TCA enzymes and regulation of TCA cycle, Metabolism, Mitochondrial iron-sulfur cluster biogenesis, Respiratory electron transport
UniProt: Q9H1K1
Entrez ID: 23479
|
Does Knockout of CLDN23 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
CLDN23
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CLDN23 (claudin 23)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: bicellular tight junction assembly, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion; MF: identical protein binding, protein binding, structural molecule activity; CC: anchoring junction, bicellular tight junction, membrane, plasma membrane
Pathways: Cell adhesion molecules - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Epithelial to mesenchymal transition in colorectal cancer, Hepatitis C - Homo sapiens (human), Leukocyte transendothelial migration - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Tight junction - Homo sapiens (human), Tight junction interactions
UniProt: Q96B33
Entrez ID: 137075
|
Does Knockout of NUP214 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
NUP214
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: NUP214 (nucleoporin 214)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: RNA export from nucleus, intracellular protein transport, mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein export from nucleus, protein import into nucleus, protein transport, regulation of cell cycle, regulation of nucleocytoplasmic transport; MF: nuclear export signal receptor activity, nuclear localization sequence binding, protein binding, structural constituent of nuclear pore; CC: cytoplasmic side of nuclear pore, cytosol, nuclear envelope, nuclear pore, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, BMP receptor signaling, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, HuR (ELAVL1) binds and stabilizes mRNA, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Regulation of cytoplasmic and nuclear SMAD2/3 signaling, Regulation of mRNA stability by proteins that bind AU-rich elements, Rev-mediated nuclear export of HIV RNA, Role of Calcineurin-dependent NFAT signaling in lymphocytes, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Signaling events mediated by HDAC Class I, Signaling events mediated by HDAC Class II, Sumoylation by RanBP2 regulates transcriptional repression, TGF-beta Signaling Pathway, TGF_beta_Receptor, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, cycling of ran in nucleocytoplasmic transport, mechanism of protein import into the nucleus, snRNP Assembly, sumoylation by ranbp2 regulates transcriptional repression, tRNA processing, tRNA processing in the nucleus
UniProt: P35658
Entrez ID: 8021
|
Does Knockout of DTYMK in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
DTYMK
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: DTYMK (deoxythymidylate kinase)
Type: protein-coding
Summary: Enables thymidylate kinase activity. Predicted to be involved in dTDP biosynthetic process; dTTP biosynthetic process; and dUDP biosynthetic process. Predicted to act upstream of or within cellular response to growth factor stimulus and nucleotide biosynthetic process. Predicted to be located in mitochondrial intermembrane space and mitochondrial matrix. Predicted to be active in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to growth factor stimulus, dTDP biosynthetic process, dTTP biosynthetic process, dUDP biosynthetic process, nucleotide biosynthetic process, thymidine biosynthetic process; MF: ATP binding, dTMP kinase activity, kinase activity, nucleoside diphosphate kinase activity, nucleotide binding, transferase activity; CC: cytoplasm, cytosol, mitochondrion, nucleus
Pathways: Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), pyrimidine deoxyribonucleotide phosphorylation, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides biosynthesis from CTP, superpathway of pyrimidine deoxyribonucleoside salvage, superpathway of pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis
UniProt: P23919
Entrez ID: 1841
|
Does Knockout of ADNP2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
ADNP2
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: ADNP2 (ADNP homeobox 2)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in several processes, including cellular response to oxidative stress; cellular response to retinoic acid; and positive regulation of cell growth. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: nervous system development, regulation of gene expression, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, protein binding, zinc ion binding; CC: chromatin, nucleus
Pathways:
UniProt: Q6IQ32
Entrez ID: 22850
|
Does Knockout of NUDT21 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
NUDT21
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: NUDT21 (nudix hydrolase 21)
Type: protein-coding
Summary: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell differentiation, co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA alternative polyadenylation, mRNA processing, positive regulation of pro-B cell differentiation, positive regulation of stem cell differentiation, post-transcriptional regulation of gene expression, protein heterotetramerization, protein tetramerization; MF: RNA binding, chromatin binding, histone deacetylase binding, identical protein binding, mRNA 3'-UTR AU-rich region binding, mRNA binding, protein binding, protein homodimerization activity; CC: centriolar satellite, centrosome, cytoplasm, mRNA cleavage and polyadenylation specificity factor complex, mRNA cleavage factor complex, nuclear body, nucleoplasm, nucleus, paraspeckles
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human)
UniProt: O43809
Entrez ID: 11051
|
Does Knockout of AKAP9 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,396
|
Knockout
|
AKAP9
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: AKAP9 (A-kinase anchoring protein 9)
Type: protein-coding
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: cellular response to cAMP, chemical synaptic transmission, maintenance of centrosome location, microtubule nucleation, positive regulation of microtubule polymerization, protein-containing complex localization, regulation of Golgi organization, regulation of cardiac muscle cell action potential involved in regulation of contraction, regulation of heart rate by cardiac conduction, regulation of membrane repolarization, regulation of ventricular cardiac muscle cell membrane repolarization, response to electrical stimulus, signal transduction; MF: DNA binding, molecular adaptor activity, potassium channel activator activity, potassium channel regulator activity, protein binding, protein kinase A regulatory subunit binding, signaling receptor binding, transmembrane transporter binding; CC: Golgi apparatus, Golgi stack, centrosome, cis-Golgi network, cytoplasm, cytoskeleton, cytosol, dendritic branch, extrinsic component of postsynaptic density membrane, glutamatergic synapse, microtubule organizing center, neuronal cell body, potassium channel complex, synaptic membrane, voltage-gated potassium channel complex
Pathways: G Protein Signaling Pathways, NO-cGMP-PKG mediated Neuroprotection, protein kinase a at the centrosome
UniProt: Q99996
Entrez ID: 10142
|
Does Knockout of CDC42EP4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
CDC42EP4
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CDC42EP4 (CDC42 effector protein 4)
Type: protein-coding
Summary: The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Rho protein signal transduction, cellular response to type II interferon, positive regulation of actin filament polymerization, positive regulation of pseudopodium assembly, regulation of cell shape; MF: RNA binding, protein binding, small GTPase binding; CC: actin cytoskeleton, adherens junction, cytoplasm, cytoskeleton, cytosol, endomembrane system, membrane, microtubule cytoskeleton, phagocytic vesicle, plasma membrane
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RAC2 GTPase cycle, RHO GTPase cycle, RHOQ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9H3Q1
Entrez ID: 23580
|
Does Knockout of MRPS26 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
MRPS26
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: MRPS26 (mitochondrial ribosomal protein S26)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: Q9BYN8
Entrez ID: 64949
|
Does Activation of GBF1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
GBF1
|
response to virus
|
Hepatoma Cell Line
|
Gene: GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1)
Type: protein-coding
Summary: This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: COPI coating of Golgi vesicle, Golgi disassembly, Golgi organization, Golgi to endosome transport, cell activation involved in immune response, cellular response to virus, cilium assembly, endomembrane system organization, endoplasmic reticulum to Golgi vesicle-mediated transport, endoplasmic reticulum-Golgi intermediate compartment organization, endosomal transport, establishment of monopolar cell polarity, neutrophil chemotaxis, post-Golgi vesicle-mediated transport, protein localization to Golgi apparatus, protein localization to endoplasmic reticulum exit site, protein localization to endoplasmic reticulum tubular network, protein transport, reactive oxygen species biosynthetic process, regulation of ARF protein signal transduction, regulation of mitotic cell cycle, regulation of protein localization to cell surface, retrograde transport, endosome to Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; MF: guanyl-nucleotide exchange factor activity, lipid binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,5-bisphosphate binding, protein binding; CC: Golgi apparatus, Golgi apparatus subcompartment, Golgi membrane, Golgi stack, cell leading edge, cis-Golgi network, cytoplasm, cytosol, endoplasmic reticulum lumen, endoplasmic reticulum-Golgi intermediate compartment, lipid droplet, membrane, peroxisome, trans-Golgi network
Pathways: Arf1 pathway, Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cargo trafficking to the periciliary membrane, Cilium Assembly, ER to Golgi Anterograde Transport, Endocytosis - Homo sapiens (human), Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Organelle biogenesis and maintenance, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, VxPx cargo-targeting to cilium, adp-ribosylation factor, thrombin signaling and protease-activated receptors, trans-Golgi Network Vesicle Budding
UniProt: Q92538
Entrez ID: 8729
|
Does Knockout of POLR2F in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
POLR2F
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: POLR2F (RNA polymerase II, I and III subunit F)
Type: protein-coding
Summary: This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: DNA-templated transcription, tRNA transcription by RNA polymerase III, transcription by RNA polymerase I, transcription by RNA polymerase II; MF: DNA binding, DNA-directed RNA polymerase activity; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, RNA polymerase II, core complex, RNA polymerase III complex, cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: Abortive elongation of HIV-1 transcript in the absence of Tat, Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, B-WICH complex positively regulates rRNA expression, Cell Cycle, Chromosome Maintenance, Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , DNA Repair, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dual incision in TC-NER, ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, Eukaryotic Transcription Initiation, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene Silencing by RNA, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, HIV elongation arrest and recovery, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inhibition of DNA recombination at telomere, Innate Immune System, Late Phase of HIV Life Cycle, Metabolism of RNA, MicroRNA (miRNA) biogenesis, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, PIWI-interacting RNA (piRNA) biogenesis, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, Positive epigenetic regulation of rRNA expression, Processing of Capped Intron-Containing Pre-mRNA, RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Telomere Maintenance, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by small RNAs, Viral Infection Pathways, Viral Messenger RNA Synthesis, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P61218
Entrez ID: 5435
|
Does Knockout of FAM186B in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
FAM186B
|
response to chemicals
|
Melanoma Cell Line
|
Gene: FAM186B (family with sequence similarity 186 member B)
Type: protein-coding
Summary: This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways: IL-18 signaling pathway
UniProt: Q8IYM0
Entrez ID: 84070
|
Does Knockout of EIF5A in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
EIF5A
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: EIF5A (eukaryotic translation initiation factor 5A)
Type: protein-coding
Summary: Enables U6 snRNA binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to virus, positive regulation of apoptotic process, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of transcription by RNA polymerase II, positive regulation of translational elongation, positive regulation of translational termination, translation, translational elongation, tumor necrosis factor-mediated signaling pathway; MF: RNA binding, U6 snRNA binding, protein binding, ribosome binding, translation elongation factor activity; CC: annulate lamellae, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear pore, nucleus, synapse
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification, Translation Factors, eIF5A regulation in response to inhibition of the nuclear export system
UniProt: P63241
Entrez ID: 1984
|
Does Knockout of RAB42 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
RAB42
|
cell proliferation
|
Melanoma Cell Line
|
Gene: RAB42 (RAB42, member RAS oncogene family)
Type: protein-coding
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: membrane, plasma membrane
Pathways: Metabolism of proteins, Post-translational protein modification, RAB geranylgeranylation
UniProt: Q8N4Z0
Entrez ID: 115273
|
Does Knockout of GZMB in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
GZMB
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: GZMB (granzyme B)
Type: protein-coding
Summary: This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: apoptotic process, ceramide biosynthetic process, granzyme-mediated programmed cell death signaling pathway, killing of cells of another organism, natural killer cell mediated cytotoxicity, negative regulation of translation, plasma membrane repair, positive regulation of establishment of protein localization to mitochondrion, positive regulation of immune response to tumor cell, protein maturation, protein secretion, proteolysis, proteolysis involved in protein catabolic process, pyroptotic cell death, pyroptotic inflammatory response; MF: hydrolase activity, peptidase activity, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytolytic granule, cytolytic granule lumen, cytoplasm, cytosol, extracellular region, extracellular space, immunological synapse, lysosome, membrane, nucleus
Pathways: Allograft Rejection, Allograft rejection - Homo sapiens (human), Apoptosis, Apoptosis - Homo sapiens (human), Autoimmune thyroid disease - Homo sapiens (human), Caspase Cascade in Apoptosis, Downstream signaling in naïve CD8+ T cells, Graft-versus-host disease - Homo sapiens (human), Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex, IL12-mediated signaling events, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Oxidative phosphorylation, Transcriptional misregulation in cancer - Homo sapiens (human), Type I diabetes mellitus - Homo sapiens (human), apoptotic dna-fragmentation and tissue homeostasis, caspase cascade in apoptosis, granzyme a mediated apoptosis pathway, miRNAs involvement in the immune response in sepsis
UniProt: P10144
Entrez ID: 3002
|
Does Knockout of CLN8 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
CLN8
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CLN8 (CLN8 transmembrane ER and ERGIC protein)
Type: protein-coding
Summary: This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reticulum (ER), and may recycle between the ER and ER-Golgi intermediate compartment. Mutations in this gene are associated with a disorder characterized by progressive epilepsy with cognitive disabilities (EPMR), which is a subtype of neuronal ceroid lipofuscinoses (NCL). Patients with mutations in this gene have altered levels of sphingolipid and phospholipids in the brain. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: adult locomotory behavior, adult walking behavior, apoptotic process, associative learning, ceramide biosynthetic process, ceramide metabolic process, cholesterol metabolic process, glutamate reuptake, lipid biosynthetic process, lipid homeostasis, lipid transport, lysosome organization, macromolecule catabolic process, mitochondrial membrane organization, musculoskeletal movement, negative regulation of neuron apoptotic process, negative regulation of proteolysis, nervous system development, neurofilament cytoskeleton organization, neuromuscular process controlling balance, neuromuscular process controlling posture, neuron apoptotic process, phospholipid metabolic process, photoreceptor cell maintenance, protein catabolic process, regulation of cell size, retina development in camera-type eye, retinal rod cell apoptotic process, social behavior, somatic motor neuron differentiation, spinal cord motor neuron differentiation, visual perception; MF: ceramide binding, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, mitochondrion, presynapse
Pathways: Synaptic Vesicle Pathway
UniProt: Q9UBY8
Entrez ID: 2055
|
Does Knockout of LSM4 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
LSM4
|
cell proliferation
|
Bladder Carcinoma
|
Gene: LSM4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: P-body assembly, RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process, spliceosomal snRNP assembly; MF: PH domain binding, RNA binding, U6 snRNA binding, protein binding; CC: Lsm2-8 complex, P-body, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, cytosol, membrane, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Ciliary landscape, Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Homo sapiens (human), Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q9Y4Z0
Entrez ID: 25804
|
Does Knockout of MRPS35 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
MRPS35
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: MRPS35 (mitochondrial ribosomal protein S35)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: mitochondrial translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytosol, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Translation
UniProt: P82673
Entrez ID: 60488
|
Does Knockout of RSPO3 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,978
|
Knockout
|
RSPO3
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: RSPO3 (R-spondin 3)
Type: protein-coding
Summary: This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: Wnt signaling pathway, angiogenesis, blood vessel remodeling, branching involved in labyrinthine layer morphogenesis, canonical Wnt signaling pathway, positive regulation of Wnt signaling pathway, positive regulation of Wnt signaling pathway, planar cell polarity pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of non-canonical Wnt signaling pathway, sprouting angiogenesis; MF: frizzled binding, heparin binding, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in WNT signaling, Regulation of FZD by ubiquitination, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Transcriptional regulation by RUNX1, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q9BXY4
Entrez ID: 84870
|
Does Knockout of OXSM in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
OXSM
|
response to virus
|
Hepatoma Cell Line
|
Gene: OXSM (3-oxoacyl-ACP synthase, mitochondrial)
Type: protein-coding
Summary: This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009].
Gene Ontology: BP: acyl-CoA metabolic process, fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, medium-chain fatty acid biosynthetic process, short-chain fatty acid biosynthetic process; MF: 3-oxoacyl-[acyl-carrier-protein] synthase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, transferase activity; CC: cytosol, mitochondrial matrix, mitochondrion
Pathways: Biotin metabolism - Homo sapiens (human), Fatty acid biosynthesis - Homo sapiens (human), Metabolism of proteins, Mitochondrial fatty acid synthesis pathway, Mitochondrial protein degradation, palmitate biosynthesis
UniProt: Q9NWU1
Entrez ID: 54995
|
Does Knockout of ARRDC5 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
ARRDC5
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ARRDC5 (arrestin domain containing 5)
Type: protein-coding
Summary: Predicted to enable ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, protein transport, spermatogenesis; CC: cytoplasm, endosome, membrane, plasma membrane
Pathways:
UniProt: A6NEK1
Entrez ID: 645432
|
Does Knockout of GNG5 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
GNG5
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: GNG5 (G protein subunit gamma 5)
Type: protein-coding
Summary: G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G-protein beta-subunit binding, GTPase activity, PDZ domain binding, protein binding; CC: extracellular exosome, heterotrimeric G-protein complex, membrane, plasma membrane
Pathways: ADORA2B mediated anti-inflammatory cytokines production, ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of G protein gated Potassium channels, Activation of GABAB receptors, Activation of kainate receptors upon glutamate binding, Adrenaline,noradrenaline inhibits insulin secretion, Alcoholism - Homo sapiens (human), Anti-inflammatory response favouring Leishmania parasite infection, Apelin signaling pathway - Homo sapiens (human), Aquaporin-mediated transport, Beta-catenin independent WNT signaling, Ca2+ pathway, Calcium Regulation in the Cardiac Cell, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chaperonin-mediated protein folding, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Class B/2 (Secretin family receptors), Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Disease, Dopaminergic synapse - Homo sapiens (human), ESR-mediated signaling, Extra-nuclear estrogen signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, G Protein Signaling Pathways, G alpha (12/13) signalling events, G alpha (i) signalling events, G alpha (q) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G beta:gamma signalling through BTK, G beta:gamma signalling through CDC42, G beta:gamma signalling through PI3Kgamma, G beta:gamma signalling through PLC beta, G protein gated Potassium channels, G-protein activation, G-protein beta:gamma signalling, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Homo sapiens (human), GPCR downstream signalling, GPCR ligand binding, GPER1 signaling, Glucagon signaling in metabolic regulation, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Glutamatergic synapse - Homo sapiens (human), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Infectious disease, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Integration of energy metabolism, Inwardly rectifying K+ channels, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Leishmania infection, Leishmania parasite growth and survival, Metabolism, Metabolism of proteins, Morphine addiction - Homo sapiens (human), Myometrial relaxation and contraction pathways, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parasitic Infection Pathways, Pathways in cancer - Homo sapiens (human), Platelet activation, signaling and aggregation, Platelet homeostasis, Potassium Channels, Presynaptic function of Kainate receptors, Prostacyclin signalling through prostacyclin receptor, Protein folding, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of insulin secretion, Relaxin signaling pathway - Homo sapiens (human), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Homo sapiens (human), Serotonergic synapse - Homo sapiens (human), Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by WNT, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, Transmission across Chemical Synapses, Transport of small molecules, Vasopressin regulates renal water homeostasis via Aquaporins
UniProt: P63218
Entrez ID: 2787
|
Does Knockout of ACTG1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
ACTG1
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: ACTG1 (actin gamma 1)
Type: protein-coding
Summary: Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].
Gene Ontology: BP: angiogenesis, axonogenesis, cell motility, cellular response to type II interferon, maintenance of blood-brain barrier, morphogenesis of a polarized epithelium, platelet aggregation, positive regulation of cell migration, positive regulation of gene expression, positive regulation of wound healing, postsynaptic actin cytoskeleton organization, protein localization to bicellular tight junction, regulation of focal adhesion assembly, regulation of stress fiber assembly, regulation of synaptic vesicle endocytosis, regulation of transepithelial transport, sarcomere organization, tight junction assembly; MF: ATP binding, hydrolase activity, identical protein binding, nucleotide binding, profilin binding, protein binding, protein kinase binding, structural constituent of cytoskeleton, structural constituent of postsynaptic actin cytoskeleton, ubiquitin protein ligase binding; CC: NuA4 histone acetyltransferase complex, Schaffer collateral - CA1 synapse, actin cytoskeleton, actin filament, apical junction complex, apical part of cell, axon, basal body patch, blood microparticle, calyx of Held, cell-cell junction, cytoplasm, cytoskeleton, cytosol, dense body, extracellular exosome, extracellular space, filamentous actin, focal adhesion, membrane, myofibril, nucleus, phagocytic vesicle, plasma membrane, synapse
Pathways: Adherens junction - Homo sapiens (human), Adherens junctions interactions, Amyotrophic lateral sclerosis - Homo sapiens (human), Apoptosis - Homo sapiens (human), Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Axon guidance, Bacterial invasion of epithelial cells - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cell-extracellular matrix interactions, Clathrin-mediated endocytosis, Common Pathways Underlying Drug Addiction, Developmental Biology, Dilated cardiomyopathy - Homo sapiens (human), Disease, Diseases of signal transduction by growth factor receptors and second messengers, EPH-Ephrin signaling, EPH-ephrin mediated repulsion of cells, EPHB-mediated forward signaling, Ebola Virus Pathway on Host, Extracellular matrix organization, FCGR3A-mediated phagocytosis, Fas ligand pathway and stress induction of heat shock proteins, Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion, Focal adhesion - Homo sapiens (human), Formation of annular gap junctions, Formation of the dystrophin-glycoprotein complex (DGC), Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Gastric acid secretion - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Immune System, Infectious disease, Influenza A - Homo sapiens (human), Innate Immune System, Interaction between L1 and Ankyrins, L1CAM interactions, Leishmania infection, Leishmania phagocytosis, Leukocyte transendothelial migration - Homo sapiens (human), MAP2K and MAPK activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Mechanoregulation and pathology of YAP-TAZ via Hippo and non-Hippo mechanisms, Membrane Trafficking, Myometrial relaxation and contraction pathways, Nervous system development, Neutrophil extracellular trap formation - Homo sapiens (human), Non-integrin membrane-ECM interactions, Oncogenic MAPK signaling, Oxytocin signaling pathway - Homo sapiens (human), Paradoxical activation of RAF signaling by kinase inactive BRAF, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Phagosome - Homo sapiens (human), Platelet activation - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases Activate WASPs and WAVEs, RHO GTPases activate IQGAPs, RHOBTB GTPase Cycle, RHOBTB2 GTPase cycle, Rap1 signaling pathway - Homo sapiens (human), Recycling pathway of L1, Regulation of Actin Cytoskeleton, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation, Salmonella infection - Homo sapiens (human), Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by BRAF and RAF1 fusions, Signaling by RAF1 mutants, Signaling by RAS mutants, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by VEGF, Signaling by high-kinase activity BRAF mutants, Signaling by moderate kinase activity BRAF mutants, Signaling downstream of RAS mutants, Striated Muscle Contraction Pathway, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Tight junction - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, VEGFA-VEGFR2 Pathway, VEGFA-VEGFR2 Signaling Pathway, Vesicle-mediated transport, Vibrio cholerae infection - Homo sapiens (human), Viral myocarditis - Homo sapiens (human), Yersinia infection - Homo sapiens (human)
UniProt: P63261
Entrez ID: 71
|
Does Knockout of DAP3 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
DAP3
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: DAP3 (death associated protein 3)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: apoptotic mitochondrial changes, apoptotic process, apoptotic signaling pathway, mitochondrial translation; MF: GTP binding, GTPase activity, RNA binding, hydrolase activity, nucleotide binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrial small ribosomal subunit, mitochondrion, nucleoplasm, ribonucleoprotein complex, ribosome, small ribosomal subunit
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, TRAIL signaling pathway, Translation
UniProt: P51398
Entrez ID: 7818
|
Does Knockout of CTC1 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
CTC1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: CTC1 (CST telomere replication complex component 1)
Type: protein-coding
Summary: This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: DNA damage response, bone marrow development, chromosome organization, hematopoietic stem cell proliferation, multicellular organism growth, negative regulation of telomere maintenance via telomerase, positive regulation of DNA replication, positive regulation of fibroblast proliferation, regulation of G2/M transition of mitotic cell cycle, replicative senescence, spleen development, telomere capping, telomere maintenance, telomere maintenance via telomere lengthening, thymus development; MF: DNA binding, G-rich strand telomeric DNA binding, protein binding, single-stranded DNA binding, telomeric DNA binding; CC: CST complex, chromosome, chromosome, telomeric region, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q2NKJ3
Entrez ID: 80169
|
Does Knockout of ZNF202 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
ZNF202
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ZNF202 (zinc finger protein 202)
Type: protein-coding
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromosome; nuclear body; and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: lipid metabolic process, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: chromosome, nuclear body, nucleolus, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: O95125
Entrez ID: 7753
|
Does Knockout of RNF103-CHMP3 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
RNF103-CHMP3
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: RNF103-CHMP3 (RNF103-CHMP3 readthrough)
Type: protein-coding
Summary: This locus represents naturally occurring read-through transcription between the neighboring RNF103 (ring finger protein 103) and CHMP3 (charged multivesicular body protein 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Oct 2011].
Gene Ontology:
Pathways: Endocytosis - Homo sapiens (human), Internalization of ErbB1, Necroptosis - Homo sapiens (human)
UniProt: Q9Y3E7
Entrez ID: 100526767
|
Does Knockout of KRT86 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
KRT86
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: KRT86 (keratin 86)
Type: protein-coding
Summary: This gene encodes a type II keratin protein, which heterodimerizes with type I keratins to form hair and nails. This gene is present in a cluster of related genes and pseudogenes on chromosome 12. Mutations in this gene have been observed in patients with the hair disease monilethrix. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: intermediate filament organization, keratinization; MF: protein binding, structural constituent of skin epidermis; CC: cytosol, extracellular space, intermediate filament, keratin filament
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: O43790
Entrez ID: 3892
|
Does Knockout of RPS16 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
RPS16
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: RPS16 (ribosomal protein S16)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to leukemia inhibitory factor, cytoplasmic translation, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62249
Entrez ID: 6217
|
Does Knockout of BCO2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
BCO2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: BCO2 (beta-carotene oxygenase 2)
Type: protein-coding
Summary: This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: carotene catabolic process, carotene metabolic process, carotenoid metabolic process, lipid metabolic process, lutein catabolic process, lycopene catabolic process, regulation of mitochondrial membrane potential, regulation of reactive oxygen species metabolic process, retinal metabolic process, retinoic acid metabolic process, xanthophyll catabolic process, xanthophyll metabolic process, zeaxanthin catabolic process; MF: 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity, beta,beta-carotene-9',10'-cleaving oxygenase activity, beta-carotene 15,15'-dioxygenase activity, carotenoid dioxygenase activity, dioxygenase activity, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; CC: mitochondrial matrix, mitochondrion
Pathways: Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, Retinoid metabolism and transport, Sensory Perception, Visual phototransduction, Vitamin A and carotenoid metabolism
UniProt: Q9BYV7
Entrez ID: 83875
|
Does Knockout of SLC25A3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
SLC25A3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SLC25A3 (solute carrier family 25 member 3)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial phosphate ion transmembrane transport, phosphate ion transmembrane transport, proton transmembrane transport; MF: phosphate transmembrane transporter activity, phosphate:proton symporter activity, protein binding, protein-containing complex binding, symporter activity; CC: extracellular exosome, membrane, mitochondrial inner membrane, mitochondrion, plasma membrane
Pathways: C-MYB transcription factor network
UniProt: Q00325
Entrez ID: 5250
|
Does Knockout of OGG1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
OGG1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: OGG1 (8-oxoguanine DNA glycosylase)
Type: protein-coding
Summary: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair, base-excision repair, AP site formation, cellular response to reactive oxygen species, depurination, depyrimidination, negative regulation of double-strand break repair via single-strand annealing, nucleotide-excision repair, positive regulation of gene expression via chromosomal CpG island demethylation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, response to oxidative stress, response to radiation; MF: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity, DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, catalytic activity, class I DNA-(apurinic or apyrimidinic site) endonuclease activity, damaged DNA binding, endonuclease activity, enzyme binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, lyase activity, microtubule binding, oxidized purine DNA binding, oxidized purine nucleobase lesion DNA N-glycosylase activity, protein binding; CC: cytosol, mitochondrial matrix, mitochondrion, nuclear matrix, nuclear speck, nucleoplasm, nucleus, protein-containing complex
Pathways: Base Excision Repair, Base excision repair - Homo sapiens (human), Base-Excision Repair, AP Site Formation, DNA Repair, DNA Repair Pathways Full Network, Defective Base Excision Repair Associated with OGG1, Defective OGG1 Localization, Depurination, Disease, Diseases of Base Excision Repair, Diseases of DNA repair, Recognition and association of DNA glycosylase with site containing an affected purine, Validated transcriptional targets of TAp63 isoforms
UniProt: O15527
Entrez ID: 4968
|
Does Knockout of UGT1A6 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 0
| 180
|
Knockout
|
UGT1A6
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: UGT1A6 (UDP glucuronosyltransferase family 1 member A6)
Type: protein-coding
Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: negative regulation of fatty acid metabolic process, xenobiotic metabolic process; MF: UDP-glycosyltransferase activity, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity, glycosyltransferase activity, protein heterodimerization activity, protein homodimerization activity, retinoic acid binding, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Acetaminophen Metabolism Pathway, Aryl Hydrocarbon Receptor Pathway, Ascorbate and aldarate metabolism - Homo sapiens (human), Aspirin ADME, Bile secretion - Homo sapiens (human), Biological oxidations, Chemical carcinogenesis - Homo sapiens (human), Codeine and Morphine Metabolism, Constitutive Androstane Receptor Pathway, Drug ADME, Drug metabolism - cytochrome P450 - Homo sapiens (human), Drug metabolism - other enzymes - Homo sapiens (human), Estrogen metabolism, Glucuronidation, Metabolism, Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human), Metapathway biotransformation Phase I and II, NRF2 pathway, Nuclear Receptors Meta-Pathway, Oxidative Stress, Paracetamol ADME, Pentose and glucuronate interconversions - Homo sapiens (human), Phase II - Conjugation of compounds, Phenytoin (Antiarrhythmic) Action Pathway, Porphyrin and chlorophyll metabolism - Homo sapiens (human), Pregnane X receptor pathway, Retinol metabolism - Homo sapiens (human), Steroid hormone biosynthesis - Homo sapiens (human), nicotine degradation III, nicotine degradation IV, oxidative stress induced gene expression via nrf2
UniProt: P19224
Entrez ID: 54578
|
Does Knockout of KREMEN1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
KREMEN1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: KREMEN1 (kringle containing transmembrane protein 1)
Type: protein-coding
Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Mutations in this gene result in ectodermal dysplasia. This protein has also been found to be a functional receptor for Coxsackievirus A10 and may be an alternative entry receptor for SARS-CoV-2. [provided by RefSeq, Nov 2021].
Gene Ontology: BP: Wnt signaling pathway, apoptotic process, cell communication, limb development, negative regulation of axon regeneration, negative regulation of canonical Wnt signaling pathway, negative regulation of ossification, regulation of canonical Wnt signaling pathway, signal transduction; MF: protein binding, transmembrane signaling receptor activity; CC: membrane, neuronal cell body, plasma membrane
Pathways: Disease, Diseases of signal transduction by growth factor receptors and second messengers, LncRNA involvement in canonical Wnt signaling and colorectal cancer, Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Signal Transduction, Signaling by LRP5 mutants , Signaling by WNT, Signaling by WNT in cancer, TCF dependent signaling in response to WNT, Wnt, Wnt signaling, Wnt signaling network, ncRNAs involved in Wnt signaling in hepatocellular carcinoma
UniProt: Q96MU8
Entrez ID: 83999
|
Does Knockout of TBC1D3C in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
TBC1D3C
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: TBC1D3C (TBC1 domain family member 3C)
Type: protein-coding
Summary: This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014].
Gene Ontology: MF: GTPase activator activity; CC: endosome, membrane, plasma membrane
Pathways: Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q6IPX1, Q8IZP1
Entrez ID: 414060
|
Does Knockout of SDE2 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
SDE2
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: SDE2 (spliceosome associated SDE2)
Type: protein-coding
Summary: Enables damaged DNA binding activity. Involved in several processes, including cellular response to UV; mitotic G1 DNA damage checkpoint signaling; and protein ubiquitination. Located in several cellular components, including Golgi apparatus; cytosol; and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA replication, RNA splicing, cell division, cellular response to UV, endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), mRNA cis splicing, via spliceosome, mRNA processing, mitotic G1 DNA damage checkpoint signaling, protein processing, protein ubiquitination, ribosome biogenesis; MF: DNA binding, RNA binding, damaged DNA binding, protein binding, snoRNA binding; CC: Golgi apparatus, cytoplasm, cytosol, mitochondrion, nuclear speck, nucleoplasm, nucleus, plasma membrane
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q6IQ49
Entrez ID: 163859
|
Does Inhibition of PSMA7 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
PSMA7
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PSMA7 (proteasome 20S subunit alpha 7)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: identical protein binding, protein binding; CC: cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), proteasome complex, y branching of actin filaments
UniProt: O14818
Entrez ID: 5688
|
Does Knockout of HNRNPM in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
HNRNPM
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: HNRNPM (heterogeneous nuclear ribonucleoprotein M)
Type: protein-coding
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding, protein domain specific binding; CC: catalytic step 2 spliceosome, extracellular exosome, membrane, nuclear matrix, nucleolus, nucleoplasm, nucleus, paraspeckles, ribonucleoprotein complex, spliceosomal complex, synapse
Pathways: FGFR2 alternative splicing, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Receptor Tyrosine Kinases, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P52272
Entrez ID: 4670
|
Does Knockout of UBE2L3 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
UBE2L3
|
cell proliferation
|
T-lymphoma cell line
|
Gene: UBE2L3 (ubiquitin conjugating enzyme E2 L3)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cell cycle phase transition, cell population proliferation, cellular response to glucocorticoid stimulus, cellular response to steroid hormone stimulus, positive regulation of DNA-templated transcription, positive regulation of protein targeting to mitochondrion, positive regulation of protein ubiquitination, protein K11-linked ubiquitination, protein modification by small protein conjugation, protein modification process, protein polyubiquitination, protein ubiquitination, regulation of DNA-templated transcription, ubiquitin-dependent protein catabolic process; MF: ATP binding, RNA binding, enzyme binding, nucleotide binding, protein binding, transcription coactivator activity, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin protein ligase binding, ubiquitin-like protein transferase activity, ubiquitin-protein transferase activator activity, ubiquitin-protein transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adaptive Immune System, Alpha-synuclein signaling, Antigen processing: Ubiquitination & Proteasome degradation, Autophagy, BARD1 signaling events, Class I MHC mediated antigen processing & presentation, Death Receptor Signaling, E3 ubiquitin ligases ubiquitinate target proteins, Immune System, Macroautophagy, Metabolism of proteins, Mitophagy, PINK1-PRKN Mediated Mitophagy, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Parkinson,s disease pathway, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Programmed Cell Death, Protein ubiquitination, RIPK1-mediated regulated necrosis, Regulated Necrosis, Regulation of TNFR1 signaling, Regulation of necroptotic cell death, Selective autophagy, Signal Transduction, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, TNF signaling, Ubiquitin mediated proteolysis - Homo sapiens (human), role of parkin in ubiquitin-proteasomal pathway
UniProt: P68036
Entrez ID: 7332
|
Does Knockout of NAT8L in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
NAT8L
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: NAT8L (N-acetyltransferase 8 like)
Type: protein-coding
Summary: This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specific protein and is the N-acetylaspartate (NAA) biosynthetic enzyme, catalyzing the NAA synthesis from L-aspartate and acetyl-CoA. NAA is a major storage and transport form of acetyl coenzyme A specific to the nervous system. The gene mutation results in primary NAA deficiency (hypoacetylaspartia). [provided by RefSeq, Dec 2010].
Gene Ontology: MF: L-aspartate N-acetyltransferase activity, N-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, protein binding, transferase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion
Pathways: Alanine, aspartate and glutamate metabolism - Homo sapiens (human), Aspartate and asparagine metabolism, Metabolism, Metabolism of amino acids and derivatives, Metapathway biotransformation Phase I and II
UniProt: Q8N9F0
Entrez ID: 339983
|
Does Knockout of DDX54 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
DDX54
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: DDX54 (DEAD-box helicase 54)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The nucleolar protein encoded by this gene interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. Alternative splice variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA metabolic process, RNA processing, estrogen receptor signaling pathway, negative regulation of DNA-templated transcription, rRNA processing; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nuclear estrogen receptor binding, nucleic acid binding, nucleotide binding, signaling receptor binding, transcription corepressor activity; CC: Golgi apparatus, membrane, nucleolus, nucleoplasm, nucleus
Pathways: Validated nuclear estrogen receptor alpha network, Validated nuclear estrogen receptor beta network
UniProt: Q8TDD1
Entrez ID: 79039
|
Does Knockout of ADORA1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 1
| 2,368
|
Knockout
|
ADORA1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: ADORA1 (adenosine A1 receptor)
Type: protein-coding
Summary: The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled adenosine receptor signaling pathway, G protein-coupled purinergic nucleotide receptor signaling pathway, G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, apoptotic signaling pathway, cell-cell signaling, cognition, detection of temperature stimulus involved in sensory perception of pain, excitatory postsynaptic potential, fatty acid homeostasis, inflammatory response, leukocyte migration, lipid catabolic process, long-term synaptic depression, mucus secretion, negative regulation of acute inflammatory response, negative regulation of apoptotic process, negative regulation of blood pressure, negative regulation of cell population proliferation, negative regulation of circadian sleep/wake cycle, non-REM sleep, negative regulation of circadian sleep/wake cycle, sleep, negative regulation of glutamate secretion, negative regulation of hormone secretion, negative regulation of inflammatory response, negative regulation of leukocyte migration, negative regulation of lipid catabolic process, negative regulation of long-term synaptic depression, negative regulation of long-term synaptic potentiation, negative regulation of mucus secretion, negative regulation of neurotrophin production, negative regulation of synaptic transmission, GABAergic, negative regulation of synaptic transmission, glutamatergic, negative regulation of systemic arterial blood pressure, nervous system development, phagocytosis, positive regulation of MAPK cascade, positive regulation of blood pressure, positive regulation of dephosphorylation, positive regulation of lipid catabolic process, positive regulation of nucleoside transport, positive regulation of peptide secretion, positive regulation of potassium ion transport, positive regulation of systemic arterial blood pressure, protein targeting to membrane, regulation of cardiac muscle cell contraction, regulation of cardiac muscle contraction, regulation of glomerular filtration, regulation of presynaptic cytosolic calcium ion concentration, regulation of respiratory gaseous exchange by nervous system process, regulation of sensory perception of pain, response to hypoxia, response to purine-containing compound, signal transduction, temperature homeostasis, triglyceride homeostasis, vasodilation; MF: G protein-coupled adenosine receptor activity, G protein-coupled receptor activity, G protein-coupled receptor binding, G-protein beta/gamma-subunit complex binding, heat shock protein binding, heterotrimeric G-protein binding, protein binding, protein heterodimerization activity, protein-containing complex binding, purine nucleoside binding; CC: asymmetric synapse, axolemma, basolateral plasma membrane, calyx of Held, cell body, cilium, dendrite, dendritic spine, membrane, neuronal cell body, plasma membrane, postsynaptic membrane, presynaptic active zone, presynaptic membrane, synapse, terminal bouton
Pathways: Adenosine P1 receptors, Class A/1 (Rhodopsin-like receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Morphine addiction - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Nucleotide GPCRs, Nucleotide-like (purinergic) receptors, Purinergic signaling, Regulation of lipolysis in adipocytes - Homo sapiens (human), Renin secretion - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Sphingolipid signaling pathway - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P30542
Entrez ID: 134
|
Does Knockout of PPP1R1C in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
PPP1R1C
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: PPP1R1C (protein phosphatase 1 regulatory inhibitor subunit 1C)
Type: protein-coding
Summary: Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010].
Gene Ontology: BP: cell division, intracellular signal transduction, signal transduction; MF: protein binding, protein phosphatase inhibitor activity; CC: cytoplasm
Pathways:
UniProt: Q8WVI7
Entrez ID: 151242
|
Does Knockout of PRPF40A in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
PRPF40A
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PRPF40A (pre-mRNA processing factor 40A)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in several processes, including cytoskeleton organization; regulation of cell shape; and regulation of cytokinesis. Located in nuclear matrix and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, cell division, cell migration, cytoskeleton organization, mRNA cis splicing, via spliceosome, mRNA processing, mRNA splicing, via spliceosome, regulation of cell shape, regulation of cytokinesis; MF: RNA binding, protein binding; CC: U1 snRNP, U2-type prespliceosome, membrane, nuclear matrix, nuclear speck, nucleoplasm, nucleus
Pathways: Spliceosome - Homo sapiens (human), mRNA Processing
UniProt: O75400
Entrez ID: 55660
|
Does Knockout of TOP2A in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
TOP2A
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: TOP2A (DNA topoisomerase II alpha)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: DNA damage response, DNA metabolic process, DNA topological change, apoptotic chromosome condensation, chromatin organization, chromosome condensation, chromosome segregation, embryonic cleavage, female meiotic nuclear division, hematopoietic progenitor cell differentiation, positive regulation of apoptotic process, positive regulation of single stranded viral RNA replication via double stranded DNA intermediate, positive regulation of transcription by RNA polymerase II, regulation of circadian rhythm, resolution of meiotic recombination intermediates, rhythmic process, sister chromatid segregation; MF: ATP binding, ATP-dependent activity, acting on DNA, DNA binding, DNA binding, bending, DNA topoisomerase activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, RNA binding, chromatin binding, isomerase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein kinase C binding, ubiquitin binding; CC: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex, centriole, chromosome, centromeric region, condensed chromosome, cytoplasm, male germ cell nucleus, nuclear chromosome, nucleolus, nucleoplasm, nucleus, protein-containing complex, ribonucleoprotein complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, Etoposide Action Pathway, Etoposide Metabolism Pathway, G0 and Early G1, Gastric Cancer Network 1, Gastric Cancer Network 2, Metabolism of proteins, Mitotic G1 phase and G1/S transition, Post-translational protein modification, Retinoblastoma gene in cancer, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA replication proteins, Teniposide Action Pathway, Teniposide Metabolism Pathway, Transcription of E2F targets under negative control by DREAM complex, Validated transcriptional targets of deltaNp63 isoforms
UniProt: P11388
Entrez ID: 7153
|
Does Knockout of NUP155 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
NUP155
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: NUP155 (nucleoporin 155)
Type: protein-coding
Summary: Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013].
Gene Ontology: BP: RNA export from nucleus, atrial cardiac muscle cell action potential, mRNA export from nucleus, mRNA transport, miRNA processing, nuclear envelope organization, nucleocytoplasmic transport, protein import into nucleus, protein localization to nuclear inner membrane, protein localization to nucleus, protein transport, transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; MF: protein binding, structural constituent of nuclear pore; CC: cytosol, membrane, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: O75694
Entrez ID: 9631
|
Does Knockout of BSPRY in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
BSPRY
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: BSPRY (B-box and SPRY domain containing)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cell leading edge; membrane; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: calcium ion transport, cellular response to leukemia inhibitory factor, innate immune response, monoatomic ion transport; MF: metal ion binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, membrane
Pathways:
UniProt: Q5W0U4
Entrez ID: 54836
|
Does Knockout of ZFP92 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
ZFP92
|
cell proliferation
|
Cancer Cell Line
|
Gene: ZFP92 (ZFP92 zinc finger protein)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of glucose metabolic process, regulation of lipid metabolic process, regulation of transcription by RNA polymerase II, transposable element silencing; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Herpes simplex virus 1 infection - Homo sapiens (human)
UniProt: A6NM28
Entrez ID: 139735
|
Does Knockout of GGA1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
GGA1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1)
Type: protein-coding
Summary: This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi to plasma membrane transport, intracellular protein localization, intracellular protein transport, positive regulation of protein catabolic process, protein catabolic process, protein localization to cell surface, protein localization to ciliary membrane, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated transport; MF: phosphatidylinositol binding, protein binding, small GTPase binding, ubiquitin binding; CC: Golgi apparatus, cytosol, early endosome, early endosome membrane, endosome, endosome membrane, membrane, nucleoplasm, protein-containing complex, trans-Golgi network
Pathways: Lysosome - Homo sapiens (human)
UniProt: Q9UJY5
Entrez ID: 26088
|
Does Knockout of SDR39U1 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,391
|
Knockout
|
SDR39U1
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: SDR39U1 (short chain dehydrogenase/reductase family 39U member 1)
Type: protein-coding
Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) superfamily, which includes both classical and extended types. The encoded protein represents an extended type, with similarity to epimerases. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014].
Gene Ontology: CC: mitochondrion, nucleus
Pathways:
UniProt: Q9NRG7
Entrez ID: 56948
|
Does Knockout of RFC4 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
RFC4
|
cell proliferation
|
Cancer Cell Line
|
Gene: RFC4 (replication factor C subunit 4)
Type: protein-coding
Summary: The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA clamp loader activity, enzyme binding, nucleotide binding, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, Elg1 RFC-like complex, chromosome, nucleoplasm, nucleus
Pathways: ATR signaling pathway, Activation of ATR in response to replication stress, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Mismatch Repair, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, DNA replication - Homo sapiens (human), DNA strand elongation, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, Fanconi anemia pathway, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gastric Cancer Network 2, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homology Directed Repair, Impaired BRCA2 binding to RAD51, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch repair - Homo sapiens (human), Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: P35249
Entrez ID: 5984
|
Does Knockout of NFATC2 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
NFATC2
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: NFATC2 (nuclear factor of activated T cells 2)
Type: protein-coding
Summary: This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012].
Gene Ontology: BP: B cell receptor signaling pathway, DNA damage response, calcineurin-NFAT signaling cascade, cartilage development, cell migration, cellular response to calcium ion, gene expression, lncRNA transcription, myotube cell development, negative regulation of transcription by RNA polymerase II, negative regulation of vascular associated smooth muscle cell differentiation, positive regulation of B cell proliferation, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of myoblast fusion, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to xenobiotic stimulus, transcription by RNA polymerase II; MF: 14-3-3 protein binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, molecular adaptor activity, phosphatase binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus, ribonucleoprotein complex, transcription factor AP-1 complex, transcription regulator complex
Pathways: 16p11.2 distal deletion syndrome, AP-1 transcription factor network, Axon guidance - Homo sapiens (human), B Cell Receptor Signaling Pathway, B cell receptor signaling pathway - Homo sapiens (human), BCR, C-type lectin receptor signaling pathway - Homo sapiens (human), CAMKK2 Pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Calcium signaling in the CD4+ TCR pathway, Cancer immunotherapy by PD-1 blockade, Cardiac Hypertrophic Response, Cellular senescence - Homo sapiens (human), Downstream signaling in naïve CD8+ T cells, Fc-epsilon receptor I signaling in mast cells, Heart Development, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Initiation of transcription and translation elongation at the HIV-1 LTR, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Natural killer cell mediated cytotoxicity - Homo sapiens (human), Noncanonical Wnt signaling pathway, Osteoclast differentiation - Homo sapiens (human), Oxytocin signaling pathway - Homo sapiens (human), PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), Role of Calcineurin-dependent NFAT signaling in lymphocytes, T cell receptor signaling pathway - Homo sapiens (human), T-Cell Receptor and Co-stimulatory Signaling, T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, T-cell receptor (TCR) signaling pathway, TCR, Th1 and Th2 cell differentiation - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), VEGF signaling pathway - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, Validated transcriptional targets of AP1 family members Fra1 and Fra2, Vitamin D Receptor Pathway, Wnt, Wnt Signaling Pathway, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), Yersinia infection - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: Q13469
Entrez ID: 4773
|
Does Knockout of DLL1 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
DLL1
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: DLL1 (delta like canonical Notch ligand 1)
Type: protein-coding
Summary: DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Notch signaling pathway, Notch signaling pathway involved in arterial endothelial cell fate commitment, astrocyte development, cell communication, cell differentiation, cell fate determination, cell-cell signaling, cerebellar Purkinje cell layer structural organization, cerebellar molecular layer formation, clathrin-dependent endocytosis, compartment pattern specification, determination of left/right symmetry, endothelial tip cell fate specification, energy homeostasis, heart looping, hemopoiesis, inhibition of neuroepithelial cell differentiation, inner ear auditory receptor cell differentiation, inner ear development, lateral inhibition, left/right axis specification, loop of Henle development, marginal zone B cell differentiation, myeloid cell differentiation, negative regulation of Notch signaling pathway, negative regulation of cardiac muscle cell differentiation, negative regulation of cell differentiation, negative regulation of cell population proliferation, negative regulation of epidermal cell differentiation, negative regulation of epithelial cell differentiation, negative regulation of glial cell apoptotic process, negative regulation of inner ear auditory receptor cell differentiation, negative regulation of interleukin-10 production, negative regulation of myeloid cell differentiation, negative regulation of myoblast differentiation, negative regulation of neuron differentiation, nephron development, neuroepithelial cell differentiation, neuron differentiation, neuron fate specification, neuronal stem cell population maintenance, organ growth, positive regulation of Notch signaling pathway, positive regulation of cell population proliferation, positive regulation of endocytosis, positive regulation of gene expression, positive regulation of skeletal muscle tissue growth, positive regulation of sprouting angiogenesis, positive regulation of transcription by RNA polymerase II, proximal tubule development, proximal/distal pattern formation, regulation of blood pressure, regulation of cell adhesion, regulation of cell division, regulation of growth, regulation of neurogenesis, regulation of skeletal muscle tissue growth, regulation of somitogenesis, regulation of vascular endothelial growth factor receptor signaling pathway, regulation of vascular endothelial growth factor signaling pathway, retina development in camera-type eye, retina morphogenesis in camera-type eye, skeletal muscle tissue growth, skin epidermis development, somite specification, somitogenesis, spinal cord development, type B pancreatic cell development; MF: Notch binding, Tat protein binding, calcium ion binding, protein binding, receptor ligand activity, scaffold protein binding; CC: adherens junction, anchoring junction, apical plasma membrane, cytoplasmic vesicle, extracellular region, membrane, membrane raft, plasma membrane
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Breast cancer - Homo sapiens (human), Breast cancer pathway, Canonical and non-canonical Notch signaling, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Epithelial to mesenchymal transition in colorectal cancer, Formation of paraxial mesoderm, Gastrulation, Gene expression (Transcription), Gene regulatory network modelling somitogenesis, Generic Transcription Pathway, Kidney development, MECP2 regulates transcription of neuronal ligands, Mesodermal commitment pathway, NOTCH1 regulation of endothelial cell calcification, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, Nephron development, Neural Crest Differentiation, Notch, Notch Signaling, Notch Signaling Pathway Netpath, Notch signaling pathway, Notch signaling pathway - Homo sapiens (human), Osteoblast differentiation, Pathways in cancer - Homo sapiens (human), Presenilin action in Notch and Wnt signaling, RNA Polymerase II Transcription, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD Domain Mutants in Cancer, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, Signaling by NOTCH2, Signaling by NOTCH3, Somitogenesis, Somitogenesis in the context of spondylocostal dysostosis, Th1 and Th2 cell differentiation - Homo sapiens (human), Transcriptional Regulation by MECP2, proteolysis and signaling pathway of notch, segmentation clock
UniProt: O00548
Entrez ID: 28514
|
Does Knockout of CNBP in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
CNBP
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: CNBP (CCHC-type zinc finger nucleic acid binding protein)
Type: protein-coding
Summary: This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: G-quadruplex DNA formation, cholesterol homeostasis, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of cell population proliferation, positive regulation of cytoplasmic translation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription; MF: DNA binding, G-quadruplex DNA binding, RNA binding, mRNA binding, metal ion binding, nucleic acid binding, protein binding, single-stranded RNA binding, translation regulator activity, zinc ion binding; CC: cytoplasm, cytosol, endoplasmic reticulum, nucleus
Pathways: Disease, Infectious disease, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Viral Infection Pathways
UniProt: P62633
Entrez ID: 7555
|
Does Knockout of DCTPP1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
DCTPP1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: DCTPP1 (dCTP pyrophosphatase 1)
Type: protein-coding
Summary: The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: DNA protection, dCTP catabolic process, dTTP catabolic process, nucleoside triphosphate catabolic process; MF: dCTP diphosphatase activity, hydrolase activity, identical protein binding, magnesium ion binding, metal ion binding, nucleoside triphosphate diphosphatase activity, nucleotide binding, protein binding, pyrimidine deoxyribonucleotide binding, pyrophosphatase activity; CC: cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus
Pathways: Interconversion of nucleotide di- and triphosphates, Metabolism, Metabolism of nucleotides, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human)
UniProt: Q9H773
Entrez ID: 79077
|
Does Knockout of PIGP in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
PIGP
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: PIGP (phosphatidylinositol glycan anchor biosynthesis class P)
Type: protein-coding
Summary: This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: GPI anchor biosynthetic process; MF: phosphatidylinositol N-acetylglucosaminyltransferase activity, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex, membrane
Pathways: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Homo sapiens (human), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification, Synthesis of glycosylphosphatidylinositol (GPI)
UniProt: P57054
Entrez ID: 51227
|
Does Knockout of NKAIN4 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
NKAIN4
|
cell proliferation
|
Bladder Carcinoma
|
Gene: NKAIN4 (sodium/potassium transporting ATPase interacting 4)
Type: protein-coding
Summary: NKAIN4 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009].
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q8IVV8
Entrez ID: 128414
|
Does Knockout of PSMB5 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
PSMB5
|
cell proliferation
|
Bladder Carcinoma
|
Gene: PSMB5 (proteasome 20S subunit beta 5)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].
Gene Ontology: BP: proteasome assembly, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, proteolysis involved in protein catabolic process, response to oxidative stress; MF: endopeptidase activity, hydrolase activity, peptidase activity, protein binding, threonine-type endopeptidase activity; CC: centrosome, cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, beta-subunit complex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antigen processing-Cross presentation, Antigen processing: Ub, ATP-independent proteasomal degradation, Antigen processing: Ubiquitination & Proteasome degradation, Apoptosis, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Axon guidance, Beta-catenin independent WNT signaling, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Cross-presentation of soluble exogenous antigens (endosomes), Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), ER-Phagosome pathway, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, Formation of paraxial mesoderm, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Host Interactions of HIV factors, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Intracellular signaling by second messengers, KEAP1-NFE2L2 pathway, M Phase, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of polyamines, Metabolism of proteins, Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, NIK-->noncanonical NF-kB signaling, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Nuclear events mediated by NFE2L2, Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PIP3 activates AKT signaling, PTEN Regulation, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Programmed Cell Death, Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, RAF/MAP kinase cascade, RNA Polymerase II Transcription, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of ornithine decarboxylase (ODC), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SPOP-mediated proteasomal degradation of PD-L1(CD274), Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Somitogenesis, Spinocerebellar ataxia - Homo sapiens (human), Stabilization of p53, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TCR signaling, TNFR2 non-canonical NF-kB pathway, TNFalpha, The role of GTSE1 in G2/M progression after G2 checkpoint, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Vpu mediated degradation of CD4, antigen processing and presentation, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, proteasome complex
UniProt: P28074
Entrez ID: 5693
|
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