prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of SNRPG in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | SNRPG | cell proliferation | Ovarian Cancer Cell Line | Gene: SNRPG (small nuclear ribonucleoprotein polypeptide G)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear rib... |
Does Knockout of STRA8 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 1,311 | Knockout | STRA8 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: STRA8 (stimulated by retinoic acid 8)
Type: protein-coding
Summary: This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between th... |
Does Knockout of EIF2S2 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | EIF2S2 | cell proliferation | Cancer Cell Line | Gene: EIF2S2 (eukaryotic translation initiation factor 2 subunit beta)
Type: protein-coding
Summary: Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2... |
Does Knockout of DCAF4 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | DCAF4 | cell proliferation | Colorectal Cancer Cell Line | Gene: DCAF4 (DDB1 and CUL4 associated factor 4)
Type: protein-coding
Summary: This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 20... |
Does Knockout of CSTF1 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | CSTF1 | cell proliferation | T-lymphoma cell line | Gene: CSTF1 (cleavage stimulation factor subunit 1)
Type: protein-coding
Summary: This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this ... |
Does Knockout of SPECC1 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | SPECC1 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: SPECC1 (sperm antigen with calponin homology and coiled-coil domains 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving ... |
Does Knockout of MRPL32 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | MRPL32 | cell proliferation | Gastric Cancer Cell Line | Gene: MRPL32 (mitochondrial ribosomal protein L32)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of LGALS7 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | LGALS7 | cell proliferation | Cancer Cell Line | Gene: LGALS7 (galectin 7)
Type: protein-coding
Summary: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and... |
Does Knockout of FKSG49 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | FKSG49 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: FKSG49 (hepatocellular carcinoma-associated antigen HCA25b)
Type: other
Summary: hepatocellular carcinoma-associated antigen HCA25b
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 400949 |
Does Knockout of ETV4 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | ETV4 | cell proliferation | Medulloblastoma Cell Line | Gene: ETV4 (ETS variant transcription factor 4)
Type: protein-coding
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of keratinocyte differentiati... |
Does Knockout of ARF3 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | ARF3 | cell proliferation | Gastric Cancer Cell Line | Gene: ARF3 (ARF GTPase 3)
Type: protein-coding
Summary: ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and... |
Does Knockout of TTC4 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | TTC4 | cell proliferation | Melanoma Cell Line | Gene: TTC4 (tetratricopeptide repeat domain 4)
Type: protein-coding
Summary: This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative s... |
Does Knockout of CREG1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | CREG1 | cell proliferation | Colonic Cancer Cell Line | Gene: CREG1 (cellular repressor of E1A stimulated genes 1)
Type: protein-coding
Summary: The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cell... |
Does Knockout of ATF4 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | ATF4 | cell proliferation | Melanoma Cell Line | Gene: ATF4 (activating transcription factor 4)
Type: protein-coding
Summary: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also is... |
Does Activation of PCYOX1L in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | PCYOX1L | response to virus | Hepatoma Cell Line | Gene: PCYOX1L (prenylcysteine oxidase 1 like)
Type: protein-coding
Summary: Predicted to enable prenylcysteine oxidase activity. Predicted to be involved in prenylated protein catabolic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: neutrop... |
Does Knockout of TREM2 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | TREM2 | cell proliferation | T-lymphoma cell line | Gene: TREM2 (triggering receptor expressed on myeloid cells 2)
Type: protein-coding
Summary: This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic... |
Does Knockout of RPL10A in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | RPL10A | cell proliferation | Colonic Cancer Cell Line | Gene: RPL10A (ribosomal protein L10a)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene enco... |
Does Knockout of ALG12 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | ALG12 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: ALG12 (ALG12 alpha-1,6-mannosyltransferase)
Type: protein-coding
Summary: This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Ma... |
Does Knockout of DHX57 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | DHX57 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: DHX57 (DExH-box helicase 57)
Type: protein-coding
Summary: Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, RNA polymerase binding, helicase activity, hydrolase a... |
Does Knockout of CRYM in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | CRYM | response to virus | Cervical Adenocarcinoma Cell Line | Gene: CRYM (crystallin mu)
Type: protein-coding
Summary: Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparen... |
Does Knockout of DACH2 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | DACH2 | response to chemicals | Colorectal Cancer Cell Line | Gene: DACH2 (dachshund family transcription factor 2)
Type: protein-coding
Summary: This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded prote... |
Does Knockout of NUP37 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | NUP37 | cell proliferation | Multiple Myeloma Cell Line | Gene: NUP37 (nucleoporin 37)
Type: protein-coding
Summary: Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The p... |
Does Knockout of MRPS18A in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | MRPS18A | cell proliferation | Monocytic Leukemia Cell Line | Gene: MRPS18A (mitochondrial ribosomal protein S18A)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subuni... |
Does Knockout of LCOR in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | LCOR | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: LCOR (ligand dependent nuclear receptor corepressor)
Type: protein-coding
Summary: LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (F... |
Does Knockout of CNIH1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | CNIH1 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: CNIH1 (cornichon family member 1)
Type: protein-coding
Summary: Predicted to be involved in immune response and signal transduction. Predicted to be located in ER to Golgi transport vesicle membrane; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment membrane.... |
Does Knockout of NADSYN1 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | NADSYN1 | response to chemicals | Monocytic Leukemia Cell Line | Gene: NADSYN1 (NAD synthetase 1)
Type: protein-coding
Summary: Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the fina... |
Does Knockout of OVCH1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | OVCH1 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: OVCH1 (ovochymase 1)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Ge... |
Does Knockout of TECPR2 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | TECPR2 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: TECPR2 (tectonin beta-propeller repeat containing 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been impli... |
Does Knockout of ZNF235 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | ZNF235 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: ZNF235 (zinc finger protein 235)
Type: protein-coding
Summary: This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein is a member of the Kruppel family of zinc finger ... |
Does Knockout of BTNL8 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | BTNL8 | cell proliferation | Glioblastoma Cell Line | Gene: BTNL8 (butyrophilin like 8)
Type: protein-coding
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be active in external sid... |
Does Knockout of MED20 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | MED20 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: MED20 (mediator complex subunit 20)
Type: protein-coding
Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited b... |
Does Knockout of SLC6A7 in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | SLC6A7 | RNA accumulation | Monocytic Leukemia Cell Line | Gene: SLC6A7 (solute carrier family 6 member 7)
Type: protein-coding
Summary: This gene is a member of the gamma-aminobutyric acid (GABA) neurotransmitter gene family and encodes a high-affinity mammalian brain L-proline transporter protein. This transporter protein differs from other sodium-dependent p... |
Does Knockout of TCF20 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | TCF20 | cell proliferation | Melanoma Cell Line | Gene: TCF20 (transcription factor 20)
Type: protein-coding
Summary: This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the... |
Does Knockout of UCHL5 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | UCHL5 | cell proliferation | Renal Cancer Cell Line | Gene: UCHL5 (ubiquitin C-terminal hydrolase L5)
Type: protein-coding
Summary: Enables endopeptidase inhibitor activity; proteasome binding activity; and thiol-dependent deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of sm... |
Does Knockout of OR51D1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | OR51D1 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: OR51D1 (olfactory receptor family 51 subfamily D member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of ZNF223 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 69 | Knockout | ZNF223 | cell proliferation | Monocytic Leukemia Cell Line | Gene: ZNF223 (zinc finger protein 223)
Type: protein-coding
Summary: This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. [provided by RefSeq, Mar 2014].
Gene Ontology: BP: negative regula... |
Does Knockout of ADAM9 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | ADAM9 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: ADAM9 (ADAM metallopeptidase domain 9)
Type: protein-coding
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a varie... |
Does Knockout of PRB4 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | PRB4 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: PRB4 (proline rich protein BstNI subfamily 4)
Type: protein-coding
Summary: This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secreti... |
Does Knockout of TMEM72 in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | TMEM72 | cell proliferation | Astrocytoma Cell Line | Gene: TMEM72 (transmembrane protein 72)
Type: protein-coding
Summary: This gene encodes a transmembrane protein which may be expressed specifically in the kidney. [provided by RefSeq, Sep 2016].
Gene Ontology: CC: cytoplasm, early endosome membrane, membrane, nucleus, plasma membrane
P... |
Does Knockout of EIF4A1 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | EIF4A1 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: EIF4A1 (eukaryotic translation initiation factor 4A1)
Type: protein-coding
Summary: Enables double-stranded RNA binding activity. Predicted to be involved in cytoplasmic translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP:... |
Does Knockout of EEF2KMT in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | EEF2KMT | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase)
Type: protein-coding
Summary: Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr ... |
Does Knockout of NFYC in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | NFYC | cell proliferation | Bladder Carcinoma | Gene: NFYC (nuclear transcription factor Y subunit gamma)
Type: protein-coding
Summary: This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subuni... |
Does Knockout of ISCU in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | ISCU | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: ISCU (iron-sulfur cluster assembly enzyme)
Type: protein-coding
Summary: This gene encodes a component of the iron-sulfur (Fe-S) cluster scaffold. Fe-S clusters are cofactors that play a role in the function of a diverse set of enzymes, including those that regulate metabolism, iron homeostasis, a... |
Does Knockout of CLDN23 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | CLDN23 | cell proliferation | Gastric Cancer Cell Line | Gene: CLDN23 (claudin 23)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the para... |
Does Knockout of NUP214 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | NUP214 | cell proliferation | Medulloblastoma Cell Line | Gene: NUP214 (nucleoporin 214)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear po... |
Does Knockout of DTYMK in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | DTYMK | cell proliferation | Gastric Cancer Cell Line | Gene: DTYMK (deoxythymidylate kinase)
Type: protein-coding
Summary: Enables thymidylate kinase activity. Predicted to be involved in dTDP biosynthetic process; dTTP biosynthetic process; and dUDP biosynthetic process. Predicted to act upstream of or within cellular response to growth factor stimulus and... |
Does Knockout of ADNP2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | ADNP2 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: ADNP2 (ADNP homeobox 2)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in several processes, including cellular response to oxidative stress; cellular response to retinoic acid; and positive regulati... |
Does Knockout of NUDT21 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | NUDT21 | cell proliferation | Neuroblastoma Cell Line | Gene: NUDT21 (nudix hydrolase 21)
Type: protein-coding
Summary: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end process... |
Does Knockout of AKAP9 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,396 | Knockout | AKAP9 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: AKAP9 (A-kinase anchoring protein 9)
Type: protein-coding
Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations with... |
Does Knockout of CDC42EP4 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | CDC42EP4 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: CDC42EP4 (CDC42 effector protein 4)
Type: protein-coding
Summary: The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC4... |
Does Knockout of MRPS26 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | MRPS26 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: MRPS26 (mitochondrial ribosomal protein S26)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Activation of GBF1 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | GBF1 | response to virus | Hepatoma Cell Line | Gene: GBF1 (golgi brefeldin A resistant guanine nucleotide exchange factor 1)
Type: protein-coding
Summary: This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP ex... |
Does Knockout of POLR2F in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | POLR2F | cell proliferation | Colonic Cancer Cell Line | Gene: POLR2F (RNA polymerase II, I and III subunit F)
Type: protein-coding
Summary: This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunit... |
Does Knockout of FAM186B in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | FAM186B | response to chemicals | Melanoma Cell Line | Gene: FAM186B (family with sequence similarity 186 member B)
Type: protein-coding
Summary: This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009].
Gene ... |
Does Knockout of EIF5A in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | EIF5A | cell proliferation | Ovarian Cancer Cell Line | Gene: EIF5A (eukaryotic translation initiation factor 5A)
Type: protein-coding
Summary: Enables U6 snRNA binding activity and protein N-terminus binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 clas... |
Does Knockout of RAB42 in Melanoma Cell Line causally result in cell proliferation? | 0 | 527 | Knockout | RAB42 | cell proliferation | Melanoma Cell Line | Gene: RAB42 (RAB42, member RAS oncogene family)
Type: protein-coding
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resou... |
Does Knockout of GZMB in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | GZMB | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: GZMB (granzyme B)
Type: protein-coding
Summary: This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed... |
Does Knockout of CLN8 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | CLN8 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: CLN8 (CLN8 transmembrane ER and ERGIC protein)
Type: protein-coding
Summary: This gene encodes a transmembrane protein belonging to a family of proteins containing TLC domains, which are postulated to function in lipid synthesis, transport, or sensing. The protein localizes to the endoplasmic reti... |
Does Knockout of LSM4 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | LSM4 | cell proliferation | Bladder Carcinoma | Gene: LSM4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role... |
Does Knockout of MRPS35 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | MRPS35 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: MRPS35 (mitochondrial ribosomal protein S35)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.... |
Does Knockout of RSPO3 in Monocytic Leukemia Cell Line causally result in response to chemicals? | 0 | 1,978 | Knockout | RSPO3 | response to chemicals | Monocytic Leukemia Cell Line | Gene: RSPO3 (R-spondin 3)
Type: protein-coding
Summary: This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development,... |
Does Knockout of OXSM in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | OXSM | response to virus | Hepatoma Cell Line | Gene: OXSM (3-oxoacyl-ACP synthase, mitochondrial)
Type: protein-coding
Summary: This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 20... |
Does Knockout of ARRDC5 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | ARRDC5 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: ARRDC5 (arrestin domain containing 5)
Type: protein-coding
Summary: Predicted to enable ubiquitin ligase-substrate adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. [provided by Alliance of Genome Res... |
Does Knockout of GNG5 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,119 | Knockout | GNG5 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: GNG5 (G protein subunit gamma 5)
Type: protein-coding
Summary: G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor ... |
Does Knockout of ACTG1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | ACTG1 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: ACTG1 (actin gamma 1)
Type: protein-coding
Summary: Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha act... |
Does Knockout of DAP3 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | DAP3 | cell proliferation | Medulloblastoma Cell Line | Gene: DAP3 (death associated protein 3)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have ... |
Does Knockout of CTC1 in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | CTC1 | cell proliferation | Renal Cancer Cell Line | Gene: CTC1 (CST telomere replication complex component 1)
Type: protein-coding
Summary: This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enz... |
Does Knockout of ZNF202 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | ZNF202 | cell proliferation | Endometrial Cancer Cell Line | Gene: ZNF202 (zinc finger protein 202)
Type: protein-coding
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II.... |
Does Knockout of RNF103-CHMP3 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | RNF103-CHMP3 | cell proliferation | Gastric Cancer Cell Line | Gene: RNF103-CHMP3 (RNF103-CHMP3 readthrough)
Type: protein-coding
Summary: This locus represents naturally occurring read-through transcription between the neighboring RNF103 (ring finger protein 103) and CHMP3 (charged multivesicular body protein 3) genes. The read-through transcript encodes a fusion ... |
Does Knockout of KRT86 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | KRT86 | cell proliferation | Neuroblastoma Cell Line | Gene: KRT86 (keratin 86)
Type: protein-coding
Summary: This gene encodes a type II keratin protein, which heterodimerizes with type I keratins to form hair and nails. This gene is present in a cluster of related genes and pseudogenes on chromosome 12. Mutations in this gene have been observed in patient... |
Does Knockout of RPS16 in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | RPS16 | cell proliferation | Prostate Cancer Cell Line | Gene: RPS16 (ribosomal protein S16)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of BCO2 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | BCO2 | cell proliferation | Endometrial Cancer Cell Line | Gene: BCO2 (beta-carotene oxygenase 2)
Type: protein-coding
Summary: This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
... |
Does Knockout of SLC25A3 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | SLC25A3 | cell proliferation | Colonic Cancer Cell Line | Gene: SLC25A3 (solute carrier family 25 member 3)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tand... |
Does Knockout of OGG1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 815 | Knockout | OGG1 | cell proliferation | Colonic Cancer Cell Line | Gene: OGG1 (8-oxoguanine DNA glycosylase)
Type: protein-coding
Summary: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alt... |
Does Knockout of UGT1A6 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 0 | 180 | Knockout | UGT1A6 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: UGT1A6 (UDP glucuronosyltransferase family 1 member A6)
Type: protein-coding
Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretab... |
Does Knockout of KREMEN1 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 0 | 80 | Knockout | KREMEN1 | cell proliferation | Monocytic Leukemia Cell Line | Gene: KREMEN1 (kringle containing transmembrane protein 1)
Type: protein-coding
Summary: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membr... |
Does Knockout of TBC1D3C in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | TBC1D3C | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: TBC1D3C (TBC1 domain family member 3C)
Type: protein-coding
Summary: This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficki... |
Does Knockout of SDE2 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | SDE2 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: SDE2 (spliceosome associated SDE2)
Type: protein-coding
Summary: Enables damaged DNA binding activity. Involved in several processes, including cellular response to UV; mitotic G1 DNA damage checkpoint signaling; and protein ubiquitination. Located in several cellular components, including Golgi a... |
Does Inhibition of PSMA7 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,184 | Inhibition | PSMA7 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: PSMA7 (proteasome 20S subunit alpha 7)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are comp... |
Does Knockout of HNRNPM in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | HNRNPM | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: HNRNPM (heterogeneous nuclear ribonucleoprotein M)
Type: protein-coding
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These protei... |
Does Knockout of UBE2L3 in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | UBE2L3 | cell proliferation | T-lymphoma cell line | Gene: UBE2L3 (ubiquitin conjugating enzyme E2 L3)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating e... |
Does Knockout of NAT8L in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | NAT8L | cell proliferation | Ovarian Cancer Cell Line | Gene: NAT8L (N-acetyltransferase 8 like)
Type: protein-coding
Summary: This gene encodes a single-pass membrane protein, which contains a conserved sequence of the GCN5 or NAT superfamily of N-acetyltransferases and is a member of the N-acyltransferase (NAT) superfamily. This protein is a neuron-specifi... |
Does Knockout of DDX54 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | DDX54 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: DDX54 (DEAD-box helicase 54)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alterati... |
Does Knockout of ADORA1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 1 | 2,368 | Knockout | ADORA1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: ADORA1 (adenosine A1 receptor)
Type: protein-coding
Summary: The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and toge... |
Does Knockout of PPP1R1C in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | PPP1R1C | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: PPP1R1C (protein phosphatase 1 regulatory inhibitor subunit 1C)
Type: protein-coding
Summary: Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits tha... |
Does Knockout of PRPF40A in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | PRPF40A | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PRPF40A (pre-mRNA processing factor 40A)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in several processes, including cytoskeleton organization; regulation of cell shape; and regulation of cytokinesis. Located in nuclear matrix and nuclear speck. [provided by Alliance of Ge... |
Does Knockout of TOP2A in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | TOP2A | RNA accumulation | Monocytic Leukemia Cell Line | Gene: TOP2A (DNA topoisomerase II alpha)
Type: protein-coding
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the r... |
Does Knockout of NUP155 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | NUP155 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: NUP155 (nucleoporin 155)
Type: protein-coding
Summary: Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a r... |
Does Knockout of BSPRY in Monocytic Leukemia Cell Line causally result in RNA accumulation? | 0 | 1,968 | Knockout | BSPRY | RNA accumulation | Monocytic Leukemia Cell Line | Gene: BSPRY (B-box and SPRY domain containing)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cell ... |
Does Knockout of ZFP92 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | ZFP92 | cell proliferation | Cancer Cell Line | Gene: ZFP92 (ZFP92 zinc finger protein)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by R... |
Does Knockout of GGA1 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | GGA1 | cell proliferation | Gastric Cancer Cell Line | Gene: GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1)
Type: protein-coding
Summary: This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the traffi... |
Does Knockout of SDR39U1 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,391 | Knockout | SDR39U1 | response to chemicals | Non-Small Cell Lung Adenocarcinoma Cell Line | Gene: SDR39U1 (short chain dehydrogenase/reductase family 39U member 1)
Type: protein-coding
Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) superfamily, which includes both classical and extended types. The encoded protein represents an extended type, with similar... |
Does Knockout of RFC4 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | RFC4 | cell proliferation | Cancer Cell Line | Gene: RFC4 (replication factor C subunit 4)
Type: protein-coding
Summary: The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a ... |
Does Knockout of NFATC2 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | NFATC2 | cell proliferation | Renal Cancer Cell Line | Gene: NFATC2 (nuclear factor of activated T cells 2)
Type: protein-coding
Summary: This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present... |
Does Knockout of DLL1 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | DLL1 | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: DLL1 (delta like canonical Notch ligand 1)
Type: protein-coding
Summary: DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [... |
Does Knockout of CNBP in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | CNBP | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: CNBP (CCHC-type zinc finger nucleic acid binding protein)
Type: protein-coding
Summary: This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of orn... |
Does Knockout of DCTPP1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | DCTPP1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: DCTPP1 (dCTP pyrophosphatase 1)
Type: protein-coding
Summary: The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be respons... |
Does Knockout of PIGP in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | PIGP | cell proliferation | Breast Cancer Cell Line | Gene: PIGP (phosphatidylinositol glycan anchor biosynthesis class P)
Type: protein-coding
Summary: This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to ... |
Does Knockout of NKAIN4 in Bladder Carcinoma causally result in cell proliferation? | 0 | 489 | Knockout | NKAIN4 | cell proliferation | Bladder Carcinoma | Gene: NKAIN4 (sodium/potassium transporting ATPase interacting 4)
Type: protein-coding
Summary: NKAIN4 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 200... |
Does Knockout of PSMB5 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | PSMB5 | cell proliferation | Bladder Carcinoma | Gene: PSMB5 (proteasome 20S subunit beta 5)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rin... |
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