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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of NSA2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
NSA2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NSA2 (NSA2 ribosome biogenesis factor)
Type: protein-coding
Summary: This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing, ribosomal large subunit biogenesis, ribosome biogenesis; CC: nucleolus, nucleus, preribosome, preribosome, large subunit precursor, ribonucleoprotein complex
Pathways:
UniProt: O95478
Entrez ID: 10412
|
Does Knockout of ZDHHC19 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
ZDHHC19
|
response to virus
|
Hepatoma Cell Line
|
Gene: ZDHHC19 (zDHHC palmitoyltransferase 19)
Type: protein-coding
Summary: Enables protein-cysteine S-palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in Golgi membrane; endoplasmic reticulum; and perinucleolar compartment. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: aggrephagy, peptidyl-L-cysteine S-palmitoylation, positive regulation of aggrephagy, protein targeting to membrane, protein targeting to vacuole involved in autophagy; MF: acyltransferase activity, palmitoyltransferase activity, protein binding, protein-cysteine S-palmitoyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum, membrane, perinuclear region of cytoplasm, perinucleolar compartment
Pathways: 3q29 copy number variation syndrome
UniProt: Q8WVZ1
Entrez ID: 131540
|
Does Knockout of PADI1 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
PADI1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: PADI1 (peptidyl arginine deiminase 1)
Type: protein-coding
Summary: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: calcium ion binding, hydrolase activity, metal ion binding, protein binding, protein-arginine deiminase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, protein citrullination
UniProt: Q9ULC6
Entrez ID: 29943
|
Does Knockout of KRI1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
KRI1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: KRI1 (KRI1 homolog)
Type: protein-coding
Summary: This gene overlaps with the gene for cysteine endopeptidase AUT-like 4 in a head-to-tail orientation. [provided by RefSeq, Jul 2008].
Gene Ontology: CC: 90S preribosome, nucleolus
Pathways:
UniProt: Q8N9T8
Entrez ID: 65095
|
Does Knockout of TAF10 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
TAF10
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: TAF10 (TATA-box binding protein associated factor 10)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription initiation, G1/S transition of mitotic cell cycle, RNA polymerase II preinitiation complex assembly, SAGA complex assembly, allantois development, apoptotic process, chromatin remodeling, embryonic placenta development, gene expression, hepatocyte differentiation, in utero embryonic development, lateral mesodermal cell differentiation, limb development, liver development, mRNA transcription by RNA polymerase II, multicellular organism growth, positive regulation of DNA-templated transcription, positive regulation of transcription initiation by RNA polymerase II, protein-containing complex assembly, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of gene expression, regulation of transcription by RNA polymerase II, somitogenesis, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase binding, enzyme binding, histone acetyltransferase activity, identical protein binding, nuclear estrogen receptor binding, promoter-specific chromatin binding, protein binding; CC: SAGA complex, cytoplasm, male germ cell nucleus, nucleoplasm, nucleus, perinuclear region of cytoplasm, transcription factor TFIID complex, transcription factor TFTC complex, transcription preinitiation complex
Pathways: Basal transcription factors - Homo sapiens (human), C-MYC pathway, Chromatin modifying enzymes, Chromatin organization, Deubiquitination, Disease, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcription of the HIV genome, Transcriptional Regulation by TP53, Ub-specific processing proteases, Validated targets of C-MYC transcriptional activation, Viral Infection Pathways
UniProt: Q12962
Entrez ID: 6881
|
Does Knockout of DHODH in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 69
|
Knockout
|
DHODH
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DHODH (dihydroorotate dehydrogenase (quinone))
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 'de novo' UMP biosynthetic process, 'de novo' pyrimidine nucleobase biosynthetic process, UDP biosynthetic process, pyrimidine nucleotide biosynthetic process, pyrimidine ribonucleotide biosynthetic process; MF: dihydroorotase activity, dihydroorotate dehydrogenase (quinone) activity, dihydroorotate dehydrogenase activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-CH group of donors, protein binding; CC: cytoplasm, cytosol, membrane, mitochondrial inner membrane, mitochondrion, nucleoplasm
Pathways: Beta Ureidopropionase Deficiency, Dihydropyrimidinase Deficiency, MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy), Metabolism, Metabolism of nucleotides, Nucleotide biosynthesis, Pyrimidine Metabolism, Pyrimidine biosynthesis, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), UMP Synthase Deiciency (Orotic Aciduria)
UniProt: Q02127
Entrez ID: 1723
|
Does Knockout of RPS6KC1 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
RPS6KC1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: RPS6KC1 (ribosomal protein S6 kinase C1)
Type: protein-coding
Summary: Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017].
Gene Ontology: MF: ATP binding, kinase activity, lipid binding, nucleotide binding, phosphatidylinositol binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, early endosome, endosome, lysosome, membrane, organelle
Pathways:
UniProt: Q96S38
Entrez ID: 26750
|
Does Knockout of HAUS8 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
HAUS8
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: HAUS8 (HAUS augmin like complex subunit 8)
Type: protein-coding
Summary: HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010].
Gene Ontology: BP: cell division, centrosome cycle, regulation of microtubule nucleation, spindle assembly; MF: microtubule binding, protein binding; CC: HAUS complex, centrosome, cytoplasm, cytoskeleton, cytosol, microtubule, mitotic spindle microtubule, nuclear microtubule, spindle, spindle pole
Pathways: AURKA Activation by TPX2, Anchoring of the basal body to the plasma membrane, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, Cilium Assembly, G2/M Transition, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition
UniProt: Q9BT25
Entrez ID: 93323
|
Does Knockout of VSIG2 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
VSIG2
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: VSIG2 (V-set and immunoglobulin domain containing 2)
Type: protein-coding
Summary: Predicted to be located in membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q96IQ7
Entrez ID: 23584
|
Does Knockout of COG2 in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
COG2
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: COG2 (component of oligomeric golgi complex 2)
Type: protein-coding
Summary: This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009].
Gene Ontology: BP: Golgi organization, glycosylation, intra-Golgi vesicle-mediated transport, protein transport, retrograde transport, vesicle recycling within Golgi; MF: protein binding, protein-containing complex binding; CC: Golgi apparatus, Golgi membrane, Golgi stack, Golgi transport complex, membrane, trans-Golgi network membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q14746
Entrez ID: 22796
|
Does Knockout of MAGOHB in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
MAGOHB
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: MAGOHB (mago homolog B, exon junction complex subunit)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in nucleus. Part of U2-type catalytic step 1 spliceosome; U2-type precatalytic spliceosome; and exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA export from nucleus, mRNA processing, mRNA splicing, via spliceosome, mRNA transport, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, regulation of mRNA processing, regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; MF: RNA binding, protein binding; CC: U2-type catalytic step 1 spliceosome, U2-type precatalytic spliceosome, catalytic step 2 spliceosome, cytosol, exon-exon junction complex, exon-exon junction subcomplex mago-y14, neuronal cell body, nucleoplasm, nucleus, spliceosomal complex
Pathways: Axon guidance, Developmental Biology, Gene expression (Transcription), Metabolism of RNA, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, RNA transport - Homo sapiens (human), Regulation of expression of SLITs and ROBOs, Signaling by ROBO receptors, Spliceosome - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q96A72
Entrez ID: 55110
|
Does Knockout of MED6 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
MED6
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: MED6 (mediator complex subunit 6)
Type: protein-coding
Summary: Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance; MF: DNA binding, protein binding, transcription coactivator activity, transcription coactivator binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, membrane, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Hedgehog, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: O75586
Entrez ID: 10001
|
Does Knockout of ZMYM5 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
ZMYM5
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: ZMYM5 (zinc finger MYM-type containing 5)
Type: protein-coding
Summary: Predicted to enable zinc ion binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: Q9UJ78
Entrez ID: 9205
|
Does Knockout of LAPTM5 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
LAPTM5
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: LAPTM5 (lysosomal protein transmembrane 5)
Type: protein-coding
Summary: This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009].
Gene Ontology: BP: Golgi to lysosome transport, cellular response to leukemia inhibitory factor, defense response to tumor cell, induction of programmed cell death, intracellular protein transport, intrinsic apoptotic signaling pathway, negative regulation of B cell activation, negative regulation of T cell activation, negative regulation of T cell receptor signaling pathway, negative regulation of activated T cell proliferation, negative regulation of autophagic cell death, negative regulation of interleukin-2 production, negative regulation of pre-B cell receptor expression, negative regulation of type II interferon production, positive regulation of MAPK cascade, positive regulation of cytokine production involved in immune response, positive regulation of interleukin-12 production, positive regulation of interleukin-6 production, positive regulation of lysosomal membrane permeability, positive regulation of macrophage cytokine production, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of protein ubiquitination, positive regulation of proteolysis involved in protein catabolic process, positive regulation of receptor catabolic process, positive regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of ubiquitin-dependent protein catabolic process, protein localization to lysosome, protein targeting to lysosome; MF: enzyme binding, protein binding, protein sequestering activity, ubiquitin protein ligase binding; CC: cytoplasmic vesicle, cytosol, lysosomal membrane, lysosome, membrane, perinuclear region of cytoplasm, plasma membrane, protein-containing complex, transport vesicle
Pathways: Lysosome - Homo sapiens (human)
UniProt: Q13571
Entrez ID: 7805
|
Does Knockout of IPO7 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
IPO7
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: IPO7 (importin 7)
Type: protein-coding
Summary: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: innate immune response, intracellular protein transport, negative regulation of cell cycle, negative regulation of osteoblast differentiation, positive regulation of odontoblast differentiation, positive regulation of protein localization to nucleus, protein import into nucleus, protein transport; MF: GTPase regulator activity, SMAD binding, histone binding, protein binding, small GTPase binding; CC: cytoplasm, cytosol, membrane, nuclear envelope, nuclear pore, nucleoplasm, nucleus
Pathways:
UniProt: O95373
Entrez ID: 10527
|
Does Knockout of IER5 in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
IER5
|
cell proliferation
|
Cancer Cell Line
|
Gene: IER5 (immediate early response 5)
Type: protein-coding
Summary: This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to heat, positive regulation of cellular response to heat, positive regulation of transcription by RNA polymerase II, regulation of cell population proliferation; MF: identical protein binding, protein binding; CC: cytoplasm, nucleolus, nucleoplasm, nucleus, protein phosphatase type 2A complex
Pathways: VEGFA-VEGFR2 Signaling Pathway
UniProt: Q5VY09
Entrez ID: 51278
|
Does Knockout of DCTD in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
DCTD
|
cell proliferation
|
T-lymphoma cell line
|
Gene: DCTD (dCMP deaminase)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: dTMP biosynthetic process, dUMP biosynthetic process, nucleoside salvage, nucleotide biosynthetic process, pyrimidine nucleotide metabolic process; MF: 5-hydroxymethyl-dUMP N-hydrolase activity, catalytic activity, dCMP deaminase activity, hydrolase activity, identical protein binding, metal ion binding, protein binding, zinc ion binding; CC: cytoplasm, cytosol
Pathways: Beta Ureidopropionase Deficiency, Dihydropyrimidinase Deficiency, Gemcitabine Action Pathway, Gemcitabine Metabolism Pathway, Interconversion of nucleotide di- and triphosphates, MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy), Metabolism, Metabolism of nucleotides, Pyrimidine Metabolism, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), UMP Synthase Deiciency (Orotic Aciduria), pyrimidine deoxyribonucleotides biosynthesis from CTP
UniProt: P32321
Entrez ID: 1635
|
Does Activation of ABRA in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
ABRA
|
protein/peptide accumulation
|
T cell
|
Gene: ABRA (actin binding Rho activating protein)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Predicted to be involved in positive regulation of DNA-binding transcription factor activity; positive regulation of Rho protein signal transduction; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription, DNA-templated and protein import into nucleus. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin cytoskeleton organization, positive regulation of DNA-templated transcription, positive regulation of Rho protein signal transduction, positive regulation of transcription by RNA polymerase II, protein import into nucleus, protein transport, transcription by RNA polymerase II; MF: actin binding, protein binding; CC: actin cytoskeleton, cytoplasm, cytoskeleton, myofibril, plasma membrane, sarcomere
Pathways:
UniProt: Q8N0Z2
Entrez ID: 137735
|
Does Knockout of TMED10 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
TMED10
|
cell proliferation
|
Cancer Cell Line
|
Gene: TMED10 (transmembrane p24 trafficking protein 10)
Type: protein-coding
Summary: This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: COPI coating of Golgi vesicle, COPI-coated vesicle budding, COPII vesicle coating, Golgi organization, cytosol to ERGIC protein transport, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, positive regulation of interleukin-1 production, positive regulation of protein secretion, protein localization to ERGIC, protein transmembrane transport, protein transport, regulated exocytosis, regulation of amyloid-beta formation, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle cargo loading, vesicle targeting, to, from or within Golgi, vesicle-mediated transport; MF: protein binding, protein transmembrane transporter activity, syntaxin binding; CC: COPI-coated vesicle, COPII-coated ER to Golgi transport vesicle, ER to Golgi transport vesicle membrane, Golgi apparatus, Golgi membrane, cis-Golgi network, cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, gamma-secretase complex, melanosome, membrane, plasma membrane, secretory granule membrane, trans-Golgi network transport vesicle, transport vesicle, transport vesicle membrane, zymogen granule membrane
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, COPII-mediated vesicle transport, Cargo concentration in the ER, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Pathogenic Escherichia coli infection - Homo sapiens (human), Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, mRNA Processing
UniProt: P49755
Entrez ID: 10972
|
Does Activation of RNF150 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
RNF150
|
protein/peptide accumulation
|
T cell
|
Gene: RNF150 (ring finger protein 150)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, protein binding, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, membrane
Pathways:
UniProt: Q9ULK6
Entrez ID: 57484
|
Does Knockout of CHMP4B in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
CHMP4B
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: CHMP4B (charged multivesicular body protein 4B)
Type: protein-coding
Summary: This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009].
Gene Ontology: BP: autophagosome maturation, autophagy, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, macroautophagy, maintenance of lens transparency, membrane fission, midbody abscission, mitotic cytokinesis, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nervous system process, nuclear membrane reassembly, nucleus organization, plasma membrane repair, post-translational protein targeting to endoplasmic reticulum membrane, protein polymerization, protein transport, regulation of centrosome duplication, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding, viral budding from plasma membrane, viral budding via host ESCRT complex; MF: cadherin binding, identical protein binding, protein binding, protein homodimerization activity; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endosome, extracellular exosome, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, membrane coat, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleus, plasma membrane, vesicle
Pathways: Autophagy, Budding and maturation of HIV virion, Cell Cycle, Cell Cycle, Mitotic, Disease, Early SARS-CoV-2 Infection Events, Endocytosis - Homo sapiens (human), Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Infectious disease, Late Phase of HIV Life Cycle, Late endosomal microautophagy, M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Homo sapiens (human), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Sealing of the nuclear envelope (NE) by ESCRT-III, Translation of Replicase and Assembly of the Replication Transcription Complex, Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q9H444
Entrez ID: 128866
|
Does Knockout of PRCC in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
PRCC
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PRCC (proline rich mitotic checkpoint control factor)
Type: protein-coding
Summary: This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010].
Gene Ontology: CC: nuclear speck, nucleoplasm, nucleus
Pathways: IL-18 signaling pathway, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Renal cell carcinoma - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), Type 2 papillary renal cell carcinoma, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q92733
Entrez ID: 5546
|
Does Knockout of GYG1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
GYG1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: GYG1 (glycogenin 1)
Type: protein-coding
Summary: This gene encodes a member of the glycogenin family. Glycogenin is a glycosyltransferase that catalyzes the formation of a short glucose polymer from uridine diphosphate glucose in an autoglucosylation reaction. This reaction is followed by elongation and branching of the polymer, catalyzed by glycogen synthase and branching enzyme, to form glycogen. This gene is expressed in muscle and other tissues. Mutations in this gene result in glycogen storage disease XV. This gene has pseudogenes on chromosomes 1, 8 and 13 respectively. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].
Gene Ontology: BP: glycogen biosynthetic process; MF: glycogenin glucosyltransferase activity, glycosyltransferase activity, manganese ion binding, metal ion binding, protein binding, protein homodimerization activity, transferase activity; CC: cytoplasm, cytosol, extracellular region, ficolin-1-rich granule lumen, lysosomal lumen, membrane, nucleus, secretory granule lumen
Pathways: Disease, Diseases of carbohydrate metabolism, Diseases of metabolism, Glycogen Synthesis and Degradation, Glycogen breakdown (glycogenolysis), Glycogen metabolism, Glycogen storage disease type 0 (muscle GYS1), Glycogen storage disease type II (GAA), Glycogen storage disease type XV (GYG1), Glycogen storage diseases, Glycogen synthesis, Immune System, Innate Immune System, Insulin Signaling, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Myoclonic epilepsy of Lafora, Neutrophil degranulation, Starch and sucrose metabolism - Homo sapiens (human), glycogen biosynthesis
UniProt: P46976
Entrez ID: 2992
|
Does Knockout of LENG8 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
LENG8
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: LENG8 (leukocyte receptor cluster member 8)
Type: protein-coding
Summary: Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: nucleus, protein-containing complex
Pathways:
UniProt: Q96PV6
Entrez ID: 114823
|
Does Knockout of GPR88 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 0
| 1,480
|
Knockout
|
GPR88
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: GPR88 (G protein-coupled receptor 88)
Type: protein-coding
Summary: The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, adrenergic receptor signaling pathway, cellular response to light stimulus, detection of visible light, locomotory behavior, motor learning, neuromuscular process controlling balance, neuronal action potential, phototransduction, signal transduction; MF: G protein-coupled photoreceptor activity, G protein-coupled receptor activity, beta2-adrenergic receptor activity, cytoskeletal motor activity; CC: cell projection, ciliary membrane, cilium, cytoplasm, membrane, nucleus, plasma membrane
Pathways: GPCRs, Other
UniProt: Q9GZN0
Entrez ID: 54112
|
Does Knockout of CCDC7 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
CCDC7
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CCDC7 (coiled-coil domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q96M83
Entrez ID: 79741
|
Does Knockout of ROR2 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
ROR2
|
response to virus
|
Huh-7 Cell
|
Gene: ROR2 (receptor tyrosine kinase like orphan receptor 2)
Type: protein-coding
Summary: The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Wnt signaling pathway, cell surface receptor protein tyrosine kinase signaling pathway, positive regulation of cell migration, signal transduction; MF: ATP binding, Wnt-protein binding, coreceptor activity, kinase activity, metal ion binding, mitogen-activated protein kinase kinase kinase binding, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity; CC: axon, clathrin-coated endocytic vesicle membrane, membrane, plasma membrane, receptor complex
Pathways: Beta-catenin independent WNT signaling, Cardiac Progenitor Differentiation, Ectoderm Differentiation, LncRNA involvement in canonical Wnt signaling and colorectal cancer, Noncanonical Wnt signaling pathway, PCP/CE pathway, Signal Transduction, Signaling by WNT, WNT5A-dependent internalization of FZD2, FZD5 and ROR2, Wnt, Wnt Signaling Pathway, Wnt signaling, Wnt signaling network, Wnt signaling pathway - Homo sapiens (human), ncRNAs involved in Wnt signaling in hepatocellular carcinoma
UniProt: Q01974
Entrez ID: 4920
|
Does Knockout of IBA57 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
IBA57
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: IBA57 (iron-sulfur cluster assembly factor IBA57)
Type: protein-coding
Summary: The protein encoded by this gene localizes to the mitochondrion and is part of the iron-sulfur cluster assembly pathway. The encoded protein functions late in the biosynthesis of mitochondrial 4Fe-4S proteins. Defects in this gene have been associated with autosomal recessive spastic paraplegia-74 and with multiple mitochondrial dysfunctions syndrome-3. Two transcript variants encoding different isoforms have been found for this gene. The smaller isoform is not likely to be localized to the mitochondrion since it lacks the amino-terminal transit peptide. [provided by RefSeq, Jul 2015].
Gene Ontology: BP: heme biosynthetic process, iron-sulfur cluster assembly; MF: RNA binding, protein binding; CC: mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q5T440
Entrez ID: 200205
|
Does Knockout of ZNF177 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
ZNF177
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ZNF177 (zinc finger protein 177)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in blood microparticle. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: blood microparticle, nucleus
Pathways: Herpes simplex virus 1 infection - Homo sapiens (human)
UniProt: Q13360
Entrez ID: 7730
|
Does Knockout of TNFSF15 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
TNFSF15
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: TNFSF15 (TNF superfamily member 15)
Type: protein-coding
Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: activation of NF-kappaB-inducing kinase activity, cell communication, cell surface receptor signaling pathway, immune response, positive regulation of canonical NF-kappaB signal transduction, positive regulation of extrinsic apoptotic signaling pathway, signal transduction, signaling; MF: cytokine activity, protein binding, signaling receptor binding, tumor necrosis factor receptor binding; CC: extracellular region, extracellular space, membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human), Senescence and Autophagy in Cancer
UniProt: O95150
Entrez ID: 9966
|
Does Knockout of SYDE1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
SYDE1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: SYDE1 (synapse defective Rho GTPase activating protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intrauterine growth restriction (IUGR). [provided by RefSeq, Feb 2017].
Gene Ontology: BP: actin cytoskeleton organization, activation of GTPase activity, cell migration, positive regulation of trophoblast cell migration, regulation of Ras protein signal transduction, regulation of cytoskeleton organization, signal transduction; MF: GTPase activator activity, GTPase regulator activity
Pathways: CDC42 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOF GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6ZW31
Entrez ID: 85360
|
Does Knockout of IMMT in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
IMMT
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: IMMT (inner membrane mitochondrial protein)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in cristae formation. Located in mitochondrial inner membrane. Part of MICOS complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cristae formation, inner mitochondrial membrane organization, mitochondrial calcium ion homeostasis, neuron cellular homeostasis; MF: RNA binding, protein binding; CC: MIB complex, MICOS complex, SAM complex, membrane, mitochondrial crista junction, mitochondrial envelope, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion
Pathways: Cristae formation, Mitochondrial biogenesis, Organelle biogenesis and maintenance
UniProt: Q16891
Entrez ID: 10989
|
Does Knockout of PLEKHG6 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
PLEKHG6
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6)
Type: protein-coding
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Located in cell junction and centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding; CC: cell junction, cell projection, centrosome, cleavage furrow, cytoplasm, cytoskeleton, cytosol, microvillus, spindle, spindle pole
Pathways: RAC1 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, Regulation of RhoA activity, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q3KR16
Entrez ID: 55200
|
Does Knockout of CIB4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 387
|
Knockout
|
CIB4
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: CIB4 (calcium and integrin binding family member 4)
Type: protein-coding
Summary: Enables calcium ion binding activity and magnesium ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: calcium ion binding, magnesium ion binding, metal ion binding, protein binding
Pathways:
UniProt: A0PJX0
Entrez ID: 130106
|
Does Knockout of SAE1 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
SAE1
|
response to virus
|
Hepatoma Cell Line
|
Gene: SAE1 (SUMO1 activating enzyme subunit 1)
Type: protein-coding
Summary: Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010].
Gene Ontology: BP: positive regulation of protein sumoylation, positive regulation of protein targeting to mitochondrion, protein sumoylation, protein ubiquitination; MF: ATP-dependent protein binding, SUMO activating enzyme activity, enzyme activator activity, ligase activity, protein binding, protein heterodimerization activity, small protein activating enzyme binding, ubiquitin activating enzyme activity, ubiquitin-like modifier activating enzyme activity; CC: SUMO activating enzyme complex, cytoplasm, nucleoplasm, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, SUMO is conjugated to E1 (UBA2:SAE1), SUMO is transferred from E1 to E2 (UBE2I, UBC9), SUMOylation, Ubiquitin mediated proteolysis - Homo sapiens (human), basic mechanisms of sumoylation, er associated degradation (erad) pathway
UniProt: Q9UBE0
Entrez ID: 10055
|
Does Knockout of CRCP in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
CRCP
|
cell proliferation
|
Melanoma Cell Line
|
Gene: CRCP (CGRP receptor component)
Type: protein-coding
Summary: This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription initiation, defense response to virus, immune system process, innate immune response, neuropeptide signaling pathway, transcription by RNA polymerase III, transcription initiation at RNA polymerase III promoter; MF: DNA-directed RNA polymerase activity, calcitonin gene-related peptide receptor activity, nucleotide binding, protein binding; CC: DNA polymerase III complex, DNA-directed RNA polymerase complex, RNA polymerase III complex, RNA polymerase complex, acrosomal vesicle, cytosol, membrane, nucleoplasm, nucleus, plasma membrane
Pathways: Cytosolic sensors of pathogen-associated DNA , Gene expression (Transcription), Immune System, Innate Immune System, Myometrial relaxation and contraction pathways, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination
UniProt: O75575
Entrez ID: 27297
|
Does Knockout of PRELID3B in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
PRELID3B
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PRELID3B (PRELI domain containing 3B)
Type: protein-coding
Summary: Predicted to enable phosphatidic acid transfer activity. Predicted to be involved in phospholipid transport. Predicted to be active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: intermembrane lipid transfer, phospholipid transport; MF: phosphatidic acid transfer activity, protein binding; CC: mitochondrial intermembrane space, mitochondrion
Pathways:
UniProt: Q9Y3B1
Entrez ID: 51012
|
Does Knockout of FAM219B in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
FAM219B
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: FAM219B (family with sequence similarity 219 member B)
Type: protein-coding
Summary: family with sequence similarity 219 member B
Gene Ontology:
Pathways:
UniProt: Q5XKK7
Entrez ID: 57184
|
Does Activation of CDK4 in T cell causally result in protein/peptide accumulation?
| 1
| 2,425
|
Activation
|
CDK4
|
protein/peptide accumulation
|
T cell
|
Gene: CDK4 (cyclin dependent kinase 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, cell division, cellular response to interleukin-4, cellular response to ionomycin, cellular response to lipopolysaccharide, cellular response to phorbol 13-acetate 12-myristate, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of cell population proliferation, positive regulation of fibroblast proliferation, regulation of G2/M transition of mitotic cell cycle, regulation of cell cycle, regulation of gene expression, regulation of transcription initiation by RNA polymerase II, regulation of type B pancreatic cell proliferation, response to xenobiotic stimulus, signal transduction; MF: ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: bicellular tight junction, chromatin, cyclin D1-CDK4 complex, cyclin D2-CDK4 complex, cyclin D3-CDK4 complex, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus, transcription regulator complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), ATF-2 transcription factor network, Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects, Aberrant regulation of mitotic cell cycle due to RB1 defects, Adaptive Immune System, Adipogenesis, BCR, Bladder cancer, Bladder cancer - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Homo sapiens (human), Chromatin modifying enzymes, Chromatin organization, Chronic myeloid leukemia - Homo sapiens (human), Co-inhibition by PD-1, Cushing syndrome - Homo sapiens (human), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , DNA damage response, Defective binding of RB1 mutants to E2F1,(E2F2, E2F3), Developmental Biology, Disease, Diseases of Cellular Senescence, Diseases of cellular response to stress, Diseases of mitotic cell cycle, Drug-mediated inhibition of CDK4/CDK6 activity, Epstein-Barr virus infection - Homo sapiens (human), Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4, Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6, Evasion of Oncogene Induced Senescence Due to p16INK4A Defects, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4, Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6, Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects, FOXM1 transcription factor network, G1 Phase, G1 to S cell cycle control, G1/S Transition, Gene expression (Transcription), Generic Transcription Pathway, Glioblastoma signaling pathways, Glioma - Homo sapiens (human), H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity, Head and Neck Squamous Cell Carcinoma, Hepatitis C - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Influenza A - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Measles - Homo sapiens (human), Meiosis, Meiotic recombination, Melanoma, Melanoma - Homo sapiens (human), Mitotic G1 phase and G1/S transition, Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Nuclear Receptors Meta-Pathway, Oncogene Induced Senescence, Ovarian infertility, Oxidative Stress Induced Senescence, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PPAR-alpha pathway, PTK6 Regulates Cell Cycle, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), RMTs methylate histone arginines, RNA Polymerase II Transcription, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Regulation of nuclear SMAD2/3 signaling, Regulation of retinoblastoma protein, Reproduction, Retinoblastoma gene in cancer, S Phase, SCF(Skp2)-mediated degradation of p27/p21, SPOP-mediated proteasomal degradation of PD-L1(CD274), Senescence-Associated Secretory Phenotype (SASP), Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Spinal Cord Injury, T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, TGF_beta_Receptor, The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, Thyroid stimulating hormone (TSH) signaling pathway, Tight junction - Homo sapiens (human), Transcriptional regulation by RUNX2, Transcriptional regulation of granulopoiesis, Transcriptional regulation of white adipocyte differentiation, Tumor suppressor activity of SMARCB1, Ubiquitin-dependent degradation of Cyclin D, Validated targets of C-MYC transcriptional activation, Viral carcinogenesis - Homo sapiens (human), cell cycle: g1/s check point, cyclins and cell cycle regulation, estrogen responsive protein efp controls cell cycle and breast tumors growth, influence of ras and rho proteins on g1 to s transition, miRNA regulation of DNA damage response, p53 signaling pathway, p53 signaling pathway - Homo sapiens (human), rb tumor suppressor/checkpoint signaling in response to dna damage
UniProt: P11802
Entrez ID: 1019
|
Does Knockout of SLFNL1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
SLFNL1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: SLFNL1 (schlafen like 1)
Type: protein-coding
Summary: Predicted to enable ATP binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: ATP binding, nucleotide binding
Pathways:
UniProt: Q499Z3
Entrez ID: 200172
|
Does Knockout of TUBA1B in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
TUBA1B
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: TUBA1B (tubulin alpha 1b)
Type: protein-coding
Summary: Enables double-stranded RNA binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to act upstream of or within cellular response to interleukin-4. Located in microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell division, cellular response to interleukin-4, cytoskeleton-dependent intracellular transport, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, GTPase activity, double-stranded RNA binding, hydrolase activity, nucleotide binding, protein binding, structural constituent of cytoskeleton, structural molecule activity, ubiquitin protein ligase binding; CC: cilium, cytoplasm, cytoplasmic microtubule, cytoskeleton, microtubule, microtubule cytoskeleton
Pathways: Activation of AMPK downstream of NMDARs, Activation of NMDA receptors and postsynaptic events, Adaptive Immune System, Aggrephagy, Allograft Rejection, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Apoptosis - Homo sapiens (human), Asparagine N-linked glycosylation, Assembly and cell surface presentation of NMDA receptors, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Chaperonin-mediated protein folding, Cilium Assembly, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Cytokine Signaling in Immune system, Developmental Biology, Disease, Docetaxel Action Pathway, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, Formation of tubulin folding intermediates by CCT/TriC, G2/M Transition, Gap junction - Homo sapiens (human), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HCMV Early Events, HCMV Infection, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hedgehog 'off' state, Hemostasis, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Intraflagellar transport, Kinesins, L1CAM interactions, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Paclitaxel Action Pathway, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phagosome - Homo sapiens (human), Post NMDA receptor activation events, Post-chaperonin tubulin folding pathway, Post-translational protein modification, Prion disease - Homo sapiens (human), Protein folding, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, RHOH GTPase cycle, Recruitment of NuMA to mitotic centrosomes, Recycling pathway of L1, Resolution of Sister Chromatid Cohesion, Salmonella infection - Homo sapiens (human), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Hedgehog, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling events mediated by HDAC Class II, Signaling events mediated by HDAC Class III, Signaling events mediated by PRL, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, Transmission across Chemical Synapses, Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, Vinblastine Action Pathway, Vincristine Action Pathway, Vindesine Action Pathway, Vinorelbine Action Pathway, Viral Infection Pathways
UniProt: P68363
Entrez ID: 10376
|
Does Knockout of IVL in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
IVL
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: IVL (involucrin)
Type: protein-coding
Summary: Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine, keratinization, keratinocyte differentiation, peptide cross-linking, response to UV-B; CC: centrosome, cornified envelope, cytoplasm, cytosol, extracellular exosome, nuclear body
Pathways: Corticotropin-releasing hormone signaling pathway, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin, Formation of the cornified envelope, Keratinization, Validated transcriptional targets of AP1 family members Fra1 and Fra2
UniProt: P07476
Entrez ID: 3713
|
Does Knockout of MYMK in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
MYMK
|
response to virus
|
Hepatoma Cell Line
|
Gene: MYMK (myomaker, myoblast fusion factor)
Type: protein-coding
Summary: Involved in myoblast fusion. Located in plasma membrane. Implicated in Carey-Fineman-Ziter syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: muscle organ development, myoblast fusion, myoblast fusion involved in skeletal muscle regeneration, plasma membrane fusion, positive regulation of skeletal muscle hypertrophy, skeletal muscle tissue regeneration; CC: Golgi apparatus, Golgi membrane, membrane, plasma membrane
Pathways:
UniProt: A6NI61
Entrez ID: 389827
|
Does Knockout of CLP1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
CLP1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: CLP1 (cleavage factor polyribonucleotide kinase subunit 1)
Type: protein-coding
Summary: This gene encodes a member of the Clp1 family. The encoded protein is a multifunctional kinase which is a component of the tRNA splicing endonuclease complex and a component of the pre-mRNA cleavage complex II. This protein is implicated in tRNA, mRNA, and siRNA maturation. Mutations in this gene are associated with pontocerebellar hypoplasia type 10 (PCH10). Alternatively splice transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: RISC complex assembly, RNA processing, cerebellar cortex development, global gene silencing by mRNA cleavage, mRNA 3'-end processing, mRNA processing, tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: ATP binding, ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity, ATP-dependent polynucleotide 5'-hydroxyl-kinase activity, ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity, kinase activity, nucleotide binding, polynucleotide 5'-hydroxyl-kinase activity, protein binding, transferase activity; CC: cytosol, mRNA cleavage factor complex, nucleoplasm, nucleus, tRNA-intron endonuclease complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, mRNA 3'-end processing, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human), tRNA processing, tRNA processing in the nucleus
UniProt: Q92989
Entrez ID: 10978
|
Does Knockout of CHMP7 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
CHMP7
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: CHMP7 (charged multivesicular body protein 7)
Type: protein-coding
Summary: Involved in several processes, including late endosome to vacuole transport; midbody abscission; and mitotic nuclear division. Located in cytosol; nuclear envelope; and nucleoplasm. Part of ESCRT III complex. Colocalizes with chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ESCRT III complex disassembly, autophagosome maturation, autophagy, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport, late endosome to vacuole transport via multivesicular body sorting pathway, membrane fission, midbody abscission, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein localization to chromatin, protein transport, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, chromatin, cytoplasm, cytoplasmic side of plasma membrane, cytosol, kinetochore, kinetochore microtubule, lysosomal membrane, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleoplasm, nucleus, plasma membrane
Pathways: Autophagy, Budding and maturation of HIV virion, Cell Cycle, Cell Cycle, Mitotic, Disease, Early SARS-CoV-2 Infection Events, Endocytosis - Homo sapiens (human), Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Infectious disease, Late Phase of HIV Life Cycle, Late endosomal microautophagy, M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Homo sapiens (human), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Sealing of the nuclear envelope (NE) by ESCRT-III, Translation of Replicase and Assembly of the Replication Transcription Complex, Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q8WUX9
Entrez ID: 91782
|
Does Knockout of EYA4 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
EYA4
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: EYA4 (EYA transcriptional coactivator and phosphatase 4)
Type: protein-coding
Summary: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: DNA damage response, DNA repair, anatomical structure morphogenesis, cell differentiation, chromatin organization, inner ear development, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, positive regulation of DNA repair, visual perception; MF: hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, protein binding, protein tyrosine phosphatase activity; CC: cytoplasm, nucleus
Pathways: DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: O95677
Entrez ID: 2070
|
Does Knockout of NOL12 in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
NOL12
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: NOL12 (nucleolar protein 12)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, identical protein binding, protein binding, rRNA binding, single-stranded DNA binding; CC: cytoplasm, nucleolus, nucleus
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9UGY1
Entrez ID: 79159
|
Does Knockout of POLRMT in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
POLRMT
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: POLRMT (RNA polymerase mitochondrial)
Type: protein-coding
Summary: This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, mitochondrial DNA replication, mitochondrial transcription, transcription initiation at mitochondrial promoter; MF: 3'-5'-RNA exonuclease activity, 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, RNA binding, mitochondrial promoter sequence-specific DNA binding, nucleotidyltransferase activity, protein binding, sequence-specific DNA binding, transferase activity; CC: DNA-directed RNA polymerase complex, mitochondrial DNA-directed RNA polymerase complex, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, protein-containing complex
Pathways: DNA Replication, Gene expression (Transcription), Mitochondrial Gene Expression, Mitochondrial biogenesis, Mitochondrial transcription initiation, Organelle biogenesis and maintenance, Strand-asynchronous mitochondrial DNA replication, Transcription from mitochondrial promoters, Transcriptional activation of mitochondrial biogenesis
UniProt: O00411
Entrez ID: 5442
|
Does Knockout of TLX1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
TLX1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: TLX1 (T cell leukemia homeobox 1)
Type: protein-coding
Summary: This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: animal organ development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding; CC: chromatin, nucleus
Pathways: Cell Differentiation - Index, Cell Differentiation - Index expanded, Transcriptional misregulation in cancer - Homo sapiens (human)
UniProt: P31314
Entrez ID: 3195
|
Does Knockout of VPREB1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
VPREB1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: VPREB1 (V-set pre-B cell surrogate light chain 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology: CC: endoplasmic reticulum, extracellular region, immunoglobulin complex
Pathways: Cell surface interactions at the vascular wall, Hemostasis
UniProt: P12018
Entrez ID: 7441
|
Does Knockout of XPO7 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
XPO7
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: XPO7 (exportin 7)
Type: protein-coding
Summary: The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002].
Gene Ontology: BP: intracellular protein transport, nuclear transport, nucleocytoplasmic transport, protein export from nucleus, protein transport; MF: nuclear export signal receptor activity, protein binding, small GTPase binding; CC: cytoplasm, nuclear pore, nucleus
Pathways:
UniProt: Q9UIA9
Entrez ID: 23039
|
Does Knockout of NPIPA1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,119
|
Knockout
|
NPIPA1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: NPIPA1 (nuclear pore complex interacting protein family member A1)
Type: protein-coding
Summary: Predicted to be involved in mRNA transport and protein transport. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mRNA transport, protein transport; CC: membrane, nuclear membrane, nuclear pore, nucleus
Pathways:
UniProt: Q9UND3
Entrez ID: 9284
|
Does Knockout of SORL1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
SORL1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: SORL1 (sortilin related receptor 1)
Type: protein-coding
Summary: This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded preproprotein is proteolytically processed to generate the mature receptor, which likely plays roles in endocytosis and sorting. Mutations in this gene may be associated with Alzheimer's disease. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: adaptive thermogenesis, amyloid-beta formation, cell migration, diet induced thermogenesis, endocytosis, endosome to plasma membrane protein transport, insulin receptor recycling, negative regulation of BMP signaling pathway, negative regulation of amyloid precursor protein catabolic process, negative regulation of amyloid-beta formation, negative regulation of neurofibrillary tangle assembly, negative regulation of neurogenesis, negative regulation of protein-containing complex assembly, negative regulation of triglyceride catabolic process, neuropeptide signaling pathway, positive regulation of ER to Golgi vesicle-mediated transport, positive regulation of adipose tissue development, positive regulation of early endosome to recycling endosome transport, positive regulation of endocytic recycling, positive regulation of glial cell-derived neurotrophic factor production, positive regulation of insulin receptor signaling pathway, positive regulation of protein catabolic process, positive regulation of protein exit from endoplasmic reticulum, positive regulation of protein localization to early endosome, post-Golgi vesicle-mediated transport, protein localization to Golgi apparatus, protein retention in Golgi apparatus, protein targeting, protein targeting to lysosome, receptor-mediated endocytosis, regulation of smooth muscle cell migration, retrograde transport, endosome to Golgi; MF: amyloid-beta binding, aspartic-type endopeptidase inhibitor activity, low-density lipoprotein particle binding, low-density lipoprotein particle receptor activity, neuropeptide binding, protein binding, protein transporter activity, small GTPase binding, transmembrane signaling receptor activity; CC: Golgi apparatus, Golgi cisterna, Golgi membrane, cell surface, cytoplasmic vesicle, cytosol, early endosome, early endosome membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, endosome membrane, extracellular exosome, extracellular region, extracellular space, membrane, multivesicular body, multivesicular body membrane, neuronal cell body, nuclear envelope lumen, perinucleolar compartment, plasma membrane, recycling endosome, recycling endosome membrane, trans-Golgi network, transport vesicle membrane
Pathways:
UniProt: Q92673
Entrez ID: 6653
|
Does Knockout of SMCO4 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
SMCO4
|
response to virus
|
Huh-7 Cell
|
Gene: SMCO4 (single-pass membrane protein with coiled-coil domains 4)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q9NRQ5
Entrez ID: 56935
|
Does Knockout of IMP3 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
IMP3
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: IMP3 (IMP U3 small nucleolar ribonucleoprotein 3)
Type: protein-coding
Summary: This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: maturation of SSU-rRNA, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding, rRNA binding, snoRNA binding; CC: Mpp10 complex, cytosol, nucleolus, nucleoplasm, nucleus, preribosome, ribonucleoprotein complex, small-subunit processome
Pathways: IL-18 signaling pathway, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NV31
Entrez ID: 55272
|
Does Knockout of IL22RA1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
IL22RA1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: IL22RA1 (interleukin 22 receptor subunit alpha 1)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytokine-mediated signaling pathway, defense response to Gram-negative bacterium, interleukin-22-mediated signaling pathway, negative regulation of inflammatory response; MF: cytokine receptor activity, interferon receptor activity, interleukin-20 binding, interleukin-22 receptor activity, protein binding; CC: membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Immune System, Interleukin-20 family signaling, JAK-STAT signaling pathway - Homo sapiens (human), Regulatory circuits of the STAT3 signaling pathway, Signaling by Interleukins, Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human), il22 soluble receptor signaling pathway
UniProt: Q8N6P7
Entrez ID: 58985
|
Does Knockout of TCEAL2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
TCEAL2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: TCEAL2 (transcription elongation factor A like 2)
Type: protein-coding
Summary: This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. [provided by RefSeq, Jul 2008].
Gene Ontology:
Pathways:
UniProt: Q9H3H9
Entrez ID: 140597
|
Does Knockout of MED29 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
MED29
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: MED29 (mediator complex subunit 29)
Type: protein-coding
Summary: MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009].
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: protein binding, transcription coregulator activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus
Pathways: Adipogenesis, Developmental Biology, Disease, Infectious disease, Metabolism, Metabolism of lipids, PPARA activates gene expression, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: Q9NX70
Entrez ID: 55588
|
Does Knockout of CTCF in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
CTCF
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: CTCF (CCCTC-binding factor)
Type: protein-coding
Summary: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, cardiac muscle cell development, cardiac muscle cell differentiation, chromatin looping, chromatin organization, chromosome segregation, epigenetic regulation of gene expression, gene expression, genomic imprinting, heart development, in utero embryonic development, mitochondrion organization, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of gene expression, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, protein localization to chromosome, protein localization to chromosome, centromeric region, regulation of DNA-templated transcription, regulation of centromeric sister chromatid cohesion, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, chromatin insulator sequence binding, chromatin loop anchoring activity, cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coregulator binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, condensed chromosome, male germ cell nucleus, nucleolus, nucleoplasm, nucleus
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Developmental Biology, MECP2 and Associated Rett Syndrome, Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors, Prion disease pathway, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, TGF_beta_Receptor, ctcf: first multivalent nuclear factor
UniProt: P49711
Entrez ID: 10664
|
Does Knockout of AASS in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
AASS
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: AASS (aminoadipate-semialdehyde synthase)
Type: protein-coding
Summary: This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: L-lysine catabolic process, L-lysine catabolic process to acetyl-CoA via saccharopine, lysine catabolic process, negative regulation of transcription by RNA polymerase II; MF: catalytic activity, histone binding, oxidoreductase activity, saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity, saccharopine dehydrogenase (NAD+, L-lysine-forming) activity, saccharopine dehydrogenase (NADP+, L-lysine-forming) activity, saccharopine dehydrogenase activity, transcription corepressor activity; CC: cytoplasm, cytosol, mitochondrial matrix, mitochondrion, nucleus
Pathways: 2-aminoadipic 2-oxoadipic aciduria, Glutaric Aciduria Type I, Hyperlysinemia I, Familial, Hyperlysinemia II or Saccharopinuria, Lysine Degradation, Lysine catabolism, Lysine degradation - Homo sapiens (human), Metabolism, Metabolism of amino acids and derivatives, Pyridoxine dependency with seizures, Saccharopinuria/Hyperlysinemia II, Vitamin B6-dependent and responsive disorders, lysine degradation I (saccharopine pathway)
UniProt: Q9UDR5
Entrez ID: 10157
|
Does Knockout of WDR74 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
WDR74
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: WDR74 (WD repeat domain 74)
Type: protein-coding
Summary: Involved in rRNA processing and ribosomal large subunit biogenesis. Located in nucleoplasm. Colocalizes with nuclear exosome (RNase complex) and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA metabolic process, blastocyst formation, rRNA processing, ribosomal large subunit biogenesis; CC: nuclear exosome (RNase complex), nucleolus, nucleoplasm, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q6RFH5
Entrez ID: 54663
|
Does Knockout of UBE2E1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
UBE2E1
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: UBE2E1 (ubiquitin conjugating enzyme E2 E1)
Type: protein-coding
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: ISG15-protein conjugation, negative regulation of gene expression, positive regulation of transcription by RNA polymerase II, protein K48-linked ubiquitination, protein monoubiquitination, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, ISG15 transferase activity, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity; CC: cytosol, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Antiviral mechanism by IFN-stimulated genes, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Cytokine Signaling in Immune system, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, E3 ubiquitin ligases ubiquitinate target proteins, Gene expression (Transcription), Generic Transcription Pathway, ISG15 antiviral mechanism, Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Interferon Signaling, M Phase, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Phosphorylation of the APC/C, Photodynamic therapy-induced unfolded protein response, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: P51965
Entrez ID: 7324
|
Does Knockout of CNTNAP1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
CNTNAP1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: CNTNAP1 (contactin associated protein 1)
Type: protein-coding
Summary: The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009].
Gene Ontology: BP: axonogenesis, cell adhesion, central nervous system development, central nervous system myelination, cytoskeleton organization, mitochondrion organization, myelination, myelination in peripheral nervous system, neuromuscular junction development, skeletal muscle fiber, neuromuscular process, neuromuscular process controlling balance, neuromuscular process controlling posture, neuron projection development, neuron projection morphogenesis, neuronal action potential propagation, paranodal junction assembly, paranodal junction maintenance, postsynaptic density organization, protein localization to juxtaparanode region of axon, protein localization to paranode region of axon, regulation of synapse maturation, signal transduction; MF: SH3 domain binding, protein binding, signaling receptor activity; CC: anchoring junction, glutamatergic synapse, membrane, paranodal junction, paranode region of axon
Pathways: Axon guidance, Cell adhesion molecules - Homo sapiens (human), Developmental Biology, L1CAM interactions, Nervous system development, Neurofascin interactions
UniProt: P78357
Entrez ID: 8506
|
Does Knockout of FAF2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
FAF2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: FAF2 (Fas associated factor family member 2)
Type: protein-coding
Summary: The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ERAD pathway, lipid droplet organization, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, response to unfolded protein, retrograde protein transport, ER to cytosol, stress granule disassembly; MF: lipase binding, lipase inhibitor activity, protein binding, protein-macromolecule adaptor activity, ubiquitin binding, ubiquitin protein ligase binding; CC: VCP-NPL4-UFD1 AAA ATPase complex, azurophil granule lumen, cytoplasm, endoplasmic reticulum, extracellular region, lipid droplet
Pathways: Immune System, Innate Immune System, Neutrophil degranulation, RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q96CS3
Entrez ID: 23197
|
Does Knockout of METTL5 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
METTL5
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: METTL5 (methyltransferase 5, N6-adenosine)
Type: protein-coding
Summary: Enables S-adenosyl-L-methionine binding activity and rRNA (adenine-N6-)-methyltransferase activity. Involved in positive regulation of translation and rRNA methylation. Located in nucleus; postsynapse; and presynapse. Implicated in autosomal recessive intellectual developmental disorder-72. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: methylation, positive regulation of translation, rRNA methylation, rRNA processing, stem cell differentiation; MF: S-adenosyl-L-methionine binding, S-adenosylmethionine-dependent methyltransferase activity, methyltransferase activity, nucleic acid binding, protein binding, rRNA (adenine-N6-)-methyltransferase activity, transferase activity; CC: cell projection, cytosol, fibrillar center, nucleolus, nucleus, postsynapse, presynapse, synapse
Pathways:
UniProt: Q9NRN9
Entrez ID: 29081
|
Does Knockout of LHPP in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
LHPP
|
response to virus
|
Lung Cancer Cell Line
|
Gene: LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase)
Type: protein-coding
Summary: Enables inorganic diphosphatase activity and protein homodimerization activity. Involved in phosphate-containing compound metabolic process. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: hydrolase activity, inorganic diphosphate phosphatase activity, metal ion binding, phosphatase activity, protein binding, protein homodimerization activity; CC: cytoplasm, cytosol, nuclear speck, nucleus
Pathways: Metabolism, Oxidative phosphorylation - Homo sapiens (human), Pyrophosphate hydrolysis
UniProt: Q9H008
Entrez ID: 64077
|
Does Knockout of GPRIN2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
GPRIN2
|
cell proliferation
|
Cancer Cell Line
|
Gene: GPRIN2 (G protein regulated inducer of neurite outgrowth 2)
Type: protein-coding
Summary: Predicted to be involved in neuron projection development. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: O60269
Entrez ID: 9721
|
Does Knockout of ANGEL2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
ANGEL2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ANGEL2 (angel homolog 2)
Type: protein-coding
Summary: Enables mRNA 3'-UTR binding activity. Involved in 3'-UTR-mediated mRNA stabilization and negative regulation of mitotic cell cycle. Located in Cajal body and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, mitochondrial mRNA 3'-end processing, negative regulation of mitotic cell cycle; MF: catalytic activity, mRNA 3'-UTR binding; CC: Cajal body, cytoplasm, mitochondrial matrix, mitochondrion
Pathways:
UniProt: Q5VTE6
Entrez ID: 90806
|
Does Knockout of COG3 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
COG3
|
cell proliferation
|
Bladder Carcinoma
|
Gene: COG3 (component of oligomeric golgi complex 3)
Type: protein-coding
Summary: This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011].
Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, glycosylation, intra-Golgi vesicle-mediated transport, intracellular protein transport, protein glycosylation, protein localization to organelle, protein stabilization, protein transport, retrograde transport, vesicle recycling within Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, Golgi transport complex, cis-Golgi network, cytosol, membrane, plasma membrane, trans-Golgi network membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Retrograde transport at the Trans-Golgi-Network, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q96JB2
Entrez ID: 83548
|
Does Knockout of JAG1 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
JAG1
|
response to chemicals
|
Melanoma Cell Line
|
Gene: JAG1 (jagged canonical Notch ligand 1)
Type: protein-coding
Summary: The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Nov 2019].
Gene Ontology: BP: Notch signaling pathway, T cell mediated immunity, angiogenesis, animal organ development, animal organ morphogenesis, aorta morphogenesis, aortic valve morphogenesis, blood vessel remodeling, camera-type eye development, cardiac neural crest cell development involved in outflow tract morphogenesis, cardiac right ventricle morphogenesis, cardiac septum morphogenesis, cell communication, cell fate determination, ciliary body morphogenesis, distal tubule development, endocardial cushion cell development, endothelial cell differentiation, hemopoiesis, inhibition of neuroepithelial cell differentiation, inner ear auditory receptor cell differentiation, inner ear development, keratinocyte differentiation, loop of Henle development, morphogenesis of an epithelial sheet, myoblast differentiation, negative regulation of cell differentiation, negative regulation of cell migration, negative regulation of cell-cell adhesion, negative regulation of cell-matrix adhesion, negative regulation of endothelial cell differentiation, negative regulation of fat cell differentiation, negative regulation of neuron differentiation, negative regulation of stem cell differentiation, nephron development, nervous system development, neuroendocrine cell differentiation, neuron differentiation, neuronal stem cell population maintenance, podocyte development, positive regulation of Notch signaling pathway, positive regulation of cardiac epithelial to mesenchymal transition, positive regulation of macromolecule biosynthetic process, positive regulation of myeloid cell differentiation, positive regulation of osteoblast differentiation, positive regulation of transcription by RNA polymerase II, pulmonary artery morphogenesis, pulmonary valve morphogenesis, regulation of cell population proliferation, regulation of epithelial cell proliferation, regulation of gene expression, response to muramyl dipeptide, system development; MF: Notch binding, calcium ion binding, growth factor activity, molecular adaptor activity, phospholipid binding, protein binding, structural molecule activity; CC: adherens junction, apical part of cell, apical plasma membrane, extracellular region, membrane, plasma membrane
Pathways: Activated NOTCH1 Transmits Signal to the Nucleus, Amplification and Expansion of Oncogenic Pathways as Metastatic Traits, Apelin signaling pathway - Homo sapiens (human), Breast cancer - Homo sapiens (human), Canonical and non-canonical Notch signaling, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Epithelial to mesenchymal transition in colorectal cancer, Gastrin signaling pathway, Gene expression (Transcription), Generic Transcription Pathway, H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity, Human papillomavirus infection - Homo sapiens (human), Kidney development, NOTCH1 regulation of endothelial cell calcification, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, NOTCH4 Activation and Transmission of Signal to the Nucleus, Neovascularisation processes, Nephron development, Notch, Notch Signaling, Notch Signaling Pathway Netpath, Notch signaling pathway, Notch signaling pathway - Homo sapiens (human), Osteoblast differentiation, Pathways in cancer - Homo sapiens (human), Primary focal segmental glomerulosclerosis (FSGS), RAC1 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RNA Polymerase II Transcription, RUNX3 regulates NOTCH signaling, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD Domain Mutants in Cancer, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by NOTCH4, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TNF signaling pathway - Homo sapiens (human), Th1 and Th2 cell differentiation - Homo sapiens (human), Transcriptional regulation by RUNX3, VEGFA-VEGFR2 Signaling Pathway, Validated transcriptional targets of TAp63 isoforms
UniProt: P78504
Entrez ID: 182
|
Does Knockout of AK1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
AK1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: AK1 (adenylate kinase 1)
Type: protein-coding
Summary: This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene shares readthrough transcripts with the upstream ST6GALNAC6 gene. [provided by RefSeq, Jan 2022].
Gene Ontology: BP: ADP biosynthetic process, AMP metabolic process, ATP metabolic process, nucleobase-containing compound metabolic process, nucleobase-containing small molecule interconversion, nucleoside monophosphate phosphorylation, nucleoside triphosphate biosynthetic process; MF: AMP kinase activity, ATP binding, dAMP kinase activity, kinase activity, nucleobase-containing compound kinase activity, nucleoside diphosphate kinase activity, nucleoside monophosphate kinase activity, nucleotide binding, transferase activity; CC: cytoplasm, cytosol, extracellular exosome, outer dense fiber, sperm flagellum
Pathways: AICA-Ribosiduria, Adefovir Dipivoxil Metabolism Pathway, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Gout or Kelley-Seegmiller Syndrome, Interconversion of nucleotide di- and triphosphates, Lesch-Nyhan Syndrome (LNS), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Tenofovir Metabolism Pathway, Thiamine metabolism - Homo sapiens (human), Thioguanine Action Pathway, Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, adenosine ribonucleotides <i>de novo</i> biosynthesis, purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: P00568
Entrez ID: 203
|
Does Knockout of IGFBP5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
IGFBP5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: IGFBP5 (insulin like growth factor binding protein 5)
Type: protein-coding
Summary: Enables insulin-like growth factor I binding activity. Involved in several processes, including cellular response to cAMP; regulation of smooth muscle cell migration; and regulation of smooth muscle cell proliferation. Part of insulin-like growth factor ternary complex. Biomarker of pulmonary fibrosis. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell population proliferation, cellular response to cAMP, female pregnancy, glucose homeostasis, hair follicle morphogenesis, insulin-like growth factor receptor signaling pathway, intracellular signal transduction, lung alveolus development, mammary gland involution, negative regulation of cell migration, negative regulation of growth, negative regulation of insulin-like growth factor receptor signaling pathway, negative regulation of muscle tissue development, negative regulation of osteoblast differentiation, negative regulation of skeletal muscle hypertrophy, negative regulation of smooth muscle cell migration, negative regulation of smooth muscle cell proliferation, negative regulation of translation, osteoblast differentiation, positive regulation of insulin-like growth factor receptor signaling pathway, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of vascular associated smooth muscle cell migration, positive regulation of vascular associated smooth muscle cell proliferation, regulation of cell growth, regulation of growth, regulation of insulin-like growth factor receptor signaling pathway, response to growth hormone, signal transduction, striated muscle cell differentiation, type B pancreatic cell proliferation; MF: fibronectin binding, growth factor binding, insulin-like growth factor I binding, insulin-like growth factor II binding, insulin-like growth factor binding, protein binding, receptor ligand activity; CC: cytoplasm, endoplasmic reticulum lumen, extracellular region, extracellular space, insulin-like growth factor binding protein complex, insulin-like growth factor ternary complex, nucleus
Pathways: Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Metabolism of proteins, Myometrial relaxation and contraction pathways, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Senescence and Autophagy in Cancer, Vitamin D Receptor Pathway
UniProt: P24593
Entrez ID: 3488
|
Does Knockout of NIPAL1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
NIPAL1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NIPAL1 (NIPA like domain containing 1)
Type: protein-coding
Summary: Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: magnesium ion transmembrane transport, magnesium ion transport, monoatomic ion transport; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Miscellaneous transport and binding events, Transport of small molecules
UniProt: Q6NVV3
Entrez ID: 152519
|
Does Knockout of ASB15 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
ASB15
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ASB15 (ankyrin repeat and SOCS box containing 15)
Type: protein-coding
Summary: This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Ontology: BP: intracellular signal transduction, protein ubiquitination; CC: cytosol
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, CDC42 signaling events, Class I MHC mediated antigen processing & presentation, EGFR1, EPHB forward signaling, ErbB1 downstream signaling, Immune System, Metabolism of proteins, Neddylation, Nephrin/Neph1 signaling in the kidney podocyte, Netrin-mediated signaling events, PDGFR-beta signaling pathway, Post-translational protein modification, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by focal adhesion kinase, how does salmonella hijack a cell, role of pi3k subunit p85 in regulation of actin organization and cell migration, y branching of actin filaments
UniProt: Q8WXK1
Entrez ID: 142685
|
Does Knockout of WDR5 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
WDR5
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: WDR5 (WD repeat domain 5)
Type: protein-coding
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: chromatin organization, gluconeogenesis, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of gluconeogenesis, regulation of DNA-templated transcription, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of transcription by RNA polymerase II, skeletal system development, transcription initiation-coupled chromatin remodeling; MF: histone H3K4 methyltransferase activity, histone H3K4me1 reader activity, histone H3Q5ser reader activity, histone binding, protein binding; CC: ATAC complex, MLL1 complex, MLL1/2 complex, MLL3/4 complex, NSL complex, Set1C/COMPASS complex, histone acetyltransferase complex, histone methyltransferase complex, mitotic spindle, nucleoplasm, nucleus
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, Adaptive Immune System, Cardiogenesis, Chromatin modifying enzymes, Chromatin organization, Circadian rhythm pathway, Co-inhibition by PD-1, Cushing syndrome - Homo sapiens (human), Developmental Biology, Disease, Disorders of Developmental Biology, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, Immune System, Loss of Function of KMT2D in Kabuki Syndrome, Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism of proteins, Neddylation, PKMTs methylate histone lysines, Post-translational protein modification, RMTs methylate histone arginines, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Transcriptional regulation by RUNX1
UniProt: P61964
Entrez ID: 11091
|
Does Knockout of E2F6 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
E2F6
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: E2F6 (E2F transcription factor 6)
Type: protein-coding
Summary: This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity, sequence-specific DNA binding; CC: MLL1 complex, RNA polymerase II transcription regulator complex, chromatin, nucleoplasm, nucleus, transcription regulator complex
Pathways: Cell Cycle, Cell Cycle, Mitotic, E2F transcription factor network, G1/S Transition, G1/S-Specific Transcription, Gene expression (Transcription), Generic Transcription Pathway, Mitotic G1 phase and G1/S transition, RNA Polymerase II Transcription, Transcriptional Regulation by E2F6
UniProt: O75461
Entrez ID: 1876
|
Does Knockout of TGM2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
TGM2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: TGM2 (transglutaminase 2)
Type: protein-coding
Summary: Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: apoptotic cell clearance, bone development, branching involved in salivary gland morphogenesis, cellular response to cocaine, cellular response to dopamine, cellular response to serotonin, chromatin remodeling, dopamine secretion, gene expression, negative regulation of endoplasmic reticulum calcium ion concentration, peptide cross-linking, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of GTPase activity, positive regulation of apoptotic process, positive regulation of cell adhesion, positive regulation of mitochondrial calcium ion concentration, positive regulation of neurogenesis, positive regulation of small GTPase mediated signal transduction, positive regulation of sprouting angiogenesis, protein deamination, protein homooligomerization, proteolysis, regulation of apoptotic cell clearance, regulation of apoptotic process, salivary gland cavitation; MF: GTP binding, acyltransferase activity, calcium ion binding, histone dopaminyltransferase activity, histone serotonyltransferase activity, hydrolase activity, metal ion binding, nucleotide binding, peptidase activity, peptide dopaminyltransferase activity, peptide histaminyltransferase activity, peptide noradrenalinyltransferase activity, peptide serotonyltransferase activity, protein binding, protein-glutamine gamma-glutamyltransferase activity, protein-glutamine glutaminase activity, transferase activity; CC: chromatin, chromosome, cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, extracellular matrix, extracellular region, focal adhesion, membrane, mitochondrion, nucleosome, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways: Alpha9 beta1 integrin signaling events, Beta1 integrin cell surface interactions, Huntington disease - Homo sapiens (human), IL-18 signaling pathway, Thromboxane A2 receptor signaling, phospholipase c delta in phospholipid associated cell signaling
UniProt: P21980
Entrez ID: 7052
|
Does Knockout of CROCC in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
CROCC
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: CROCC (ciliary rootlet coiled-coil, rootletin)
Type: protein-coding
Summary: Predicted to enable kinesin binding activity and structural molecule activity. Involved in several processes, including centriole-centriole cohesion; positive regulation of cilium assembly; and positive regulation of protein localization to cilium. Located in cytoskeleton; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell projection organization, cellular homeostasis, centriole-centriole cohesion, centrosome cycle, ciliary basal body organization, epithelial structure maintenance, establishment of localization in cell, establishment of organelle localization, intracellular protein localization, photoreceptor cell maintenance, positive regulation of cilium assembly, positive regulation of protein localization to cilium, protein localization to organelle; MF: actin binding, kinesin binding, protein binding, structural constituent of cytoskeleton, structural molecule activity; CC: 9+2 motile cilium, actin cytoskeleton, cell projection, centriole, centrosome, ciliary basal body, ciliary rootlet, cilium, cytoplasm, cytoskeleton, cytosol, extracellular exosome, glial cell projection, photoreceptor inner segment, plasma membrane, subapical part of cell
Pathways:
UniProt: Q5TZA2
Entrez ID: 9696
|
Does Knockout of MAOA in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
MAOA
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: MAOA (monoamine oxidase A)
Type: protein-coding
Summary: This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: biogenic amine metabolic process, catecholamine metabolic process, dopamine catabolic process, positive regulation of signal transduction; MF: flavin adenine dinucleotide binding, monoamine oxidase activity, oxidoreductase activity, primary methylamine oxidase activity, protein binding; CC: cytosol, membrane, mitochondrial outer membrane, mitochondrion
Pathways: 3-Phosphoglycerate dehydrogenase deficiency, Alcoholism - Homo sapiens (human), Alkaptonuria, Amine Oxidase reactions, Amino Acid metabolism, Amphetamine addiction - Homo sapiens (human), Arginine and proline metabolism - Homo sapiens (human), Biogenic Amine Synthesis, Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB, Biological oxidations, Citalopram Action Pathway, Citalopram Metabolism Pathway, Cocaine addiction - Homo sapiens (human), Cytokine Signaling in Immune system, Defective MAOA causes BRUNS, Dihydropyrimidine Dehydrogenase Deficiency (DHPD), Dimethylglycine Dehydrogenase Deficiency, Disease, Diseases of metabolism, Disulfiram Action Pathway, Dopamine beta-hydroxylase deficiency, Dopamine clearance from the synaptic cleft, Dopamine metabolism, Dopaminergic synapse - Homo sapiens (human), Drug metabolism - cytochrome P450 - Homo sapiens (human), Enzymatic degradation of Dopamine by monoamine oxidase, Enzymatic degradation of dopamine by COMT, Glycine and Serine Metabolism, Glycine, serine and threonine metabolism - Homo sapiens (human), Hawkinsinuria, Histidine Metabolism, Histidine metabolism - Homo sapiens (human), Histidinemia, Hyperglycinemia, non-ketotic, Immune System, Interleukin-4 and Interleukin-13 signaling, Melatonin metabolism and effects, Metabolic disorders of biological oxidation enzymes, Metabolism, Metabolism of serotonin, Monoamine oxidase-a deficiency (MAO-A), Neuronal System, Neurotransmitter Disorders, Neurotransmitter clearance, Neurotransmitter release cycle, Non Ketotic Hyperglycinemia, Norepinephrine Neurotransmitter Release Cycle, Oxidative Stress, Parkinson disease - Homo sapiens (human), Phase I - Functionalization of compounds, Phenylalanine metabolism - Homo sapiens (human), Sarcosinemia, Serotonergic synapse - Homo sapiens (human), Serotonin Transporter Activity, Serotonin clearance from the synaptic cleft, Signaling by Interleukins, Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, Transmission across Chemical Synapses, Tryptophan metabolism - Homo sapiens (human), Tyrosine Metabolism, Tyrosine metabolism - Homo sapiens (human), Tyrosinemia Type I, Tyrosinemia, transient, of the newborn, dopamine degradation, melatonin degradation II, noradrenaline and adrenaline degradation, putrescine degradation III, serotonin degradation, superpathway of melatonin degradation, superpathway of tryptophan utilization
UniProt: P21397
Entrez ID: 4128
|
Does Knockout of TIPIN in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
TIPIN
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: TIPIN (TIMELESS interacting protein)
Type: protein-coding
Summary: The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA replication checkpoint signaling, cell cycle phase transition, cell division, mitotic intra-S DNA damage checkpoint signaling, positive regulation of cell population proliferation, regulation of nuclear cell cycle DNA replication, replication fork arrest, replication fork processing, response to UV; MF: DNA binding, protein binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus, replication fork protection complex
Pathways: ATR signaling pathway, DNA Double-Strand Break Repair, DNA Repair, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homology Directed Repair, Processing of DNA double-strand break ends
UniProt: Q9BVW5
Entrez ID: 54962
|
Does Knockout of KRT40 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
KRT40
|
cell proliferation
|
Melanoma Cell Line
|
Gene: KRT40 (keratin 40)
Type: protein-coding
Summary: This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium; MF: protein binding, structural constituent of skin epidermis, structural molecule activity; CC: cytoskeleton, cytosol, intermediate filament, keratin filament
Pathways: Developmental Biology, Estrogen signaling pathway - Homo sapiens (human), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Homo sapiens (human)
UniProt: Q6A162
Entrez ID: 125115
|
Does Knockout of PDCL2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 815
|
Knockout
|
PDCL2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: PDCL2 (phosducin like 2)
Type: protein-coding
Summary: This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: acrosome assembly, cell differentiation, flagellated sperm motility, protein folding, sperm axoneme assembly, sperm flagellum assembly, spermatid development, spermatogenesis; CC: cytoplasm, endoplasmic reticulum
Pathways:
UniProt: Q8N4E4
Entrez ID: 132954
|
Does Knockout of MED6 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
MED6
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: MED6 (mediator complex subunit 6)
Type: protein-coding
Summary: Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of mediator complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II, somatic stem cell population maintenance; MF: DNA binding, protein binding, transcription coactivator activity, transcription coactivator binding, transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, membrane, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Adipogenesis, Developmental Biology, Disease, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Gene expression (Transcription), Generic Transcription Pathway, Hedgehog, Infectious disease, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Metabolism, Metabolism of lipids, PPARA activates gene expression, RNA Polymerase II Transcription, RSV-host interactions, Regulation of lipid metabolism by PPARalpha, Respiratory Syncytial Virus Infection Pathway, Transcriptional regulation of white adipocyte differentiation, Viral Infection Pathways
UniProt: O75586
Entrez ID: 10001
|
Does Knockout of DNAH12 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
DNAH12
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DNAH12 (dynein axonemal heavy chain 12)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP binding activity; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be part of dynein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: axonemal dynein complex assembly, cilium movement, microtubule-based movement; MF: ATP binding, dynein intermediate chain binding, dynein light intermediate chain binding, minus-end-directed microtubule motor activity, nucleotide binding; CC: axonemal dynein complex, cell projection, cilium, cytoplasm, cytoskeleton, dynein complex, microtubule
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
UniProt: Q6ZR08
Entrez ID: 201625
|
Does Knockout of RRP7A in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
RRP7A
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: RRP7A (ribosomal RNA processing 7 homolog A)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing and ribosomal small subunit assembly. Predicted to act upstream of or within blastocyst formation. Predicted to be located in nucleoplasm. Predicted to be part of CURI complex and UTP-C complex. Implicated in primary autosomal recessive microcephaly. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: blastocyst formation, cilium disassembly, protein localization to nucleolus, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, nucleic acid binding, protein binding; CC: CURI complex, UTP-C complex, cell junction, cell projection, centrosome, cilium, cytoplasm, cytoskeleton, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9Y3A4
Entrez ID: 27341
|
Does Knockout of EIF4E in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
EIF4E
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: EIF4E (eukaryotic translation initiation factor 4E)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, behavioral fear response, cellular response to dexamethasone stimulus, mRNA export from nucleus, mRNA transport, negative regulation of autophagy, negative regulation of neuron differentiation, negative regulation of translation, neuron differentiation, nuclear export, positive regulation of mitotic cell cycle, regulation of translation, regulation of translation at postsynapse, modulating synaptic transmission, stem cell population maintenance, translation, translational initiation; MF: DNA-binding transcription factor binding, RNA 7-methylguanosine cap binding, RNA binding, RNA cap binding, enzyme binding, eukaryotic initiation factor 4G binding, mRNA cap binding, protein binding, translation initiation factor activity; CC: P-body, RISC complex, chromatoid body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, eukaryotic translation initiation factor 4F complex, extracellular exosome, glutamatergic synapse, nuclear body, nuclear speck, nucleus, perinuclear region of cytoplasm, postsynapse
Pathways: 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression, Alpha6Beta4Integrin, Angiopoietin Like Protein 8 Regulatory Pathway, Brain-derived neurotrophic factor (BDNF) signaling pathway, EGFR Tyrosine Kinase Inhibitor Resistance, Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Fragile X Syndrome, HIF-1 signaling pathway - Homo sapiens (human), Head and Neck Squamous Cell Carcinoma, Host-pathogen interaction of human coronaviruses - MAPK signaling, Hypertrophy Model, IL2, IL6, Insulin Signaling, Insulin signaling pathway - Homo sapiens (human), Interferon type I signaling pathways, Leptin, Leptin signaling pathway, Leucine Stimulation on Insulin Signaling, Longevity regulating pathway - Homo sapiens (human), Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4), PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), RNA transport - Homo sapiens (human), Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling mediated by p38-alpha and p38-beta, Structural Pathway of Interleukin 1 (IL-1), TSLP, Translation Factors, Translation inhibitors in chronically activated PDGFRA cells, VEGFA-VEGFR2 Signaling Pathway, Validated targets of C-MYC transcriptional activation, eukaryotic protein translation, internal ribosome entry pathway, mTOR signaling pathway, mTOR signaling pathway - Homo sapiens (human), mtor signaling pathway, regulation of eif-4e and p70s6 kinase, skeletal muscle hypertrophy is regulated via akt-mtor pathway
UniProt: P06730
Entrez ID: 1977
|
Does Knockout of HUS1B in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
HUS1B
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: HUS1B (HUS1 checkpoint clamp component B)
Type: protein-coding
Summary: The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage checkpoint signaling, double-strand break repair via homologous recombination, meiotic DNA integrity checkpoint signaling, mitotic DNA replication checkpoint signaling, mitotic intra-S DNA damage checkpoint signaling, nucleotide-excision repair, telomere maintenance; CC: checkpoint clamp complex, nucleolus, site of double-strand break
Pathways: DNA damage response, miRNA regulation of DNA damage response
UniProt: Q8NHY5
Entrez ID: 135458
|
Does Knockout of RHBDD3 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 206
|
Knockout
|
RHBDD3
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: RHBDD3 (rhomboid domain containing 3)
Type: protein-coding
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within several processes, including liver development; negative regulation of natural killer cell activation; and positive regulation of protein catabolic process. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: MAPK cascade, liver development, negative regulation of natural killer cell activation, positive regulation of protein catabolic process, regulation of acute inflammatory response, regulation of protein secretion, response to xenobiotic stimulus; MF: serine-type endopeptidase activity
Pathways:
UniProt: Q9Y3P4
Entrez ID: 25807
|
Does Knockout of ZSCAN5B in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
ZSCAN5B
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ZSCAN5B (zinc finger and SCAN domain containing 5B)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: developmental process, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: A6NJL1
Entrez ID: 342933
|
Does Knockout of ZNF705D in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
ZNF705D
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: ZNF705D (zinc finger protein 705D)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: P0CH99
Entrez ID: 728957
|
Does Knockout of TMEM270 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
TMEM270
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TMEM270 (transmembrane protein 270)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q6UE05
Entrez ID: 135886
|
Does Knockout of GINS4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
GINS4
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: GINS4 (GINS complex subunit 4)
Type: protein-coding
Summary: The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008].
Gene Ontology: BP: DNA replication, DNA-templated DNA replication, double-strand break repair via break-induced replication, inner cell mass cell proliferation; CC: CMG complex, GINS complex, chromosome, cytoplasm, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA strand elongation, S Phase, Synthesis of DNA, Unwinding of DNA
UniProt: Q9BRT9
Entrez ID: 84296
|
Does Knockout of TRIQK in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
TRIQK
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: TRIQK (triple QxxK/R motif containing)
Type: protein-coding
Summary: Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q629K1
Entrez ID: 286144
|
Does Knockout of DHX36 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
DHX36
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: DHX36 (DEAH-box helicase 36)
Type: protein-coding
Summary: This gene is a member of the DEAH-box family of RNA-dependent NTPases which are named after the conserved amino acid sequence Asp-Glu-Ala-His in motif II. The protein encoded by this gene has been shown to enhance the deadenylation and decay of mRNAs with 3'-UTR AU-rich elements (ARE-mRNA). The protein has also been shown to resolve into single strands the highly stable tetramolecular DNA configuration (G4) that can form spontaneously in guanine-rich regions of DNA. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, cell differentiation, cellular response to UV, cellular response to arsenite ion, cellular response to heat, defense response to virus, immune system process, innate immune response, negative regulation of translation, ossification, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cardioblast differentiation, positive regulation of cytoplasmic translation, positive regulation of dendritic spine morphogenesis, positive regulation of gene expression, positive regulation of hematopoietic progenitor cell differentiation, positive regulation of interferon-alpha production, positive regulation of intracellular mRNA localization, positive regulation of mRNA 3'-end processing, positive regulation of myeloid dendritic cell cytokine production, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of telomere maintenance, positive regulation of telomere maintenance via telomere lengthening, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, positive regulation of translation, regulation of embryonic development, regulation of mRNA stability, regulation of transcription by RNA polymerase III, regulation of translation, response to exogenous dsRNA, response to virus, spermatogenesis, telomerase RNA stabilization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, DNA binding, DNA helicase activity, G-quadruplex DNA binding, G-quadruplex RNA binding, RNA binding, RNA helicase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, catalytic activity, acting on a nucleic acid, double-stranded RNA binding, helicase activity, histone deacetylase binding, hydrolase activity, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, magnesium ion binding, metal ion binding, nucleic acid binding, nucleotide binding, pre-miRNA binding, protein binding, single-stranded DNA binding, telomerase RNA binding, transcription cis-regulatory region binding; CC: axon, cell projection, chromosome, chromosome, telomeric region, cytoplasm, cytoplasmic stress granule, cytosol, dendrite, extracellular exosome, mitochondrion, nuclear speck, nucleoplasm, nucleus, perikaryon
Pathways: Cytosolic sensors of pathogen-associated DNA , DEx/H-box helicases activate type I IFN and inflammatory cytokines production , Immune System, Innate Immune System, RNA degradation - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway
UniProt: Q9H2U1
Entrez ID: 170506
|
Does Knockout of MIR3166 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
MIR3166
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: MIR3166 (microRNA 3166)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100423040
|
Does Knockout of USH1G in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
USH1G
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: USH1G (USH1 protein network component sans)
Type: protein-coding
Summary: This gene encodes a protein that contains three ankyrin domains, a class I PDZ-binding motif and a sterile alpha motif. The encoded protein interacts with harmonin, which is associated with Usher syndrome type 1C. This protein plays a role in the development and maintenance of the auditory and visual systems and functions in the cohesion of hair bundles formed by inner ear sensory cells. Mutations in this gene are associated with Usher syndrome type 1G (USH1G). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: equilibrioception, inner ear morphogenesis, inner ear receptor cell differentiation, inner ear receptor cell stereocilium organization, photoreceptor cell maintenance, regulation of clathrin-dependent endocytosis, sensory perception of light stimulus, sensory perception of sound; MF: identical protein binding, protein binding, spectrin binding; CC: Cajal body, actin cytoskeleton, cell projection, centrosome, ciliary basal body, ciliary base, cilium, cytoplasm, cytoskeleton, cytosol, membrane, nuclear speck, nucleus, photoreceptor cell cilium, photoreceptor connecting cilium, photoreceptor inner segment, plasma membrane, plasma membrane bounded cell projection
Pathways: Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea
UniProt: Q495M9
Entrez ID: 124590
|
Does Knockout of DEAF1 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,391
|
Knockout
|
DEAF1
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: DEAF1 (DEAF1 transcription factor)
Type: protein-coding
Summary: This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].
Gene Ontology: BP: anatomical structure morphogenesis, behavioral fear response, embryonic skeletal system development, germ cell development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, nervous system development, neural tube closure, positive regulation of DNA-templated transcription, regulation of mammary gland epithelial cell proliferation, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II, visual learning; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, extracellular region, fibrillar center, nucleoplasm, nucleus
Pathways: Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
UniProt: O75398
Entrez ID: 10522
|
Does Knockout of MAT2A in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
MAT2A
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: MAT2A (methionine adenosyltransferase 2A)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: S-adenosylmethionine biosynthetic process, TORC1 signaling, cellular response to amino acid starvation, cellular response to leukemia inhibitory factor, cellular response to methionine, cellular response to nutrient levels, negative regulation of TORC1 signaling, one-carbon metabolic process, positive regulation of TORC1 signaling, protein complex oligomerization, protein heterooligomerization, protein hexamerization, protein localization to lysosome, protein-containing complex localization; MF: ATP binding, identical protein binding, metal ion binding, methionine adenosyltransferase activity, nucleotide binding, protein binding, small molecule binding, transferase activity; CC: cytosol, methionine adenosyltransferase complex
Pathways: Betaine Metabolism, Biological oxidations, C-MYB transcription factor network, Cystathionine Beta-Synthase Deficiency, Cysteine and methionine metabolism - Homo sapiens (human), Glycine N-methyltransferase Deficiency, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, Metabolism, Methionine Adenosyltransferase Deficiency, Methionine De Novo and Salvage Pathway, Methionine Metabolism, Methylation, Methylation Pathways, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), One-carbon metabolism and related pathways, Phase II - Conjugation of compounds, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, S-adenosyl-L-methionine biosynthesis, Selenoamino Acid Metabolism, Spermidine and Spermine Biosynthesis, Trans-sulfuration and one-carbon metabolism, cysteine biosynthesis, methionine degradation, sarcosine oncometabolite pathway , superpathway of methionine degradation
UniProt: P31153
Entrez ID: 4144
|
Does Knockout of DCTN2 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
DCTN2
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: DCTN2 (dynactin subunit 2)
Type: protein-coding
Summary: This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: melanosome transport, microtubule-based process, mitotic metaphase chromosome alignment, mitotic spindle organization, protein localization to centrosome; MF: identical protein binding, protein binding, protein kinase binding, spectrin binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, dynactin complex, dynein complex, extracellular exosome, growth cone, kinetochore, membrane, microtubule, vesicle
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Salmonella infection - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vasopressin-regulated water reabsorption - Homo sapiens (human), Vesicle-mediated transport, lissencephaly gene (lis1) in neuronal migration and development
UniProt: Q13561
Entrez ID: 10540
|
Does Knockout of GPX8 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
GPX8
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: GPX8 (glutathione peroxidase 8 (putative))
Type: protein-coding
Summary: Enables peroxidase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular oxidant detoxification, cellular response to oxidative stress, response to oxidative stress; MF: glutathione peroxidase activity, oxidoreductase activity, peroxidase activity, protein binding; CC: endoplasmic reticulum lumen, membrane
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Arachidonic acid metabolism - Homo sapiens (human), Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Glutathione metabolism - Homo sapiens (human), Huntington disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Thyroid hormone synthesis - Homo sapiens (human), glutathione redox reactions I, superoxide radicals degradation
UniProt: Q8TED1
Entrez ID: 493869
|
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